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Mechanical R&D Engineer Jobs Near Me | Best Mech Jobs 2023
Introduction – Mechanical R&D Engineer Jobs Near Me Mechanical R&D Engineer Jobs Near Me: ZF Wabco has Published notification for the vacancy of R & D Engineer The educational qualification required to apply for this ZF Wabco is B.E.Mechanical Engineer Interested and eligible candidates can apply for Mechanical R&D Engineer Jobs Near Me. There is enough time to apply for any job. Read ZF…
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#automotive r&d engineer jobs near Chennai#Highest Paying R&D Engineer Jobs#Is R&D engineer a good career?#Mechanical R&D Engineer Jobs Near Me#R And D Engineer Jobs In Tamil Nadu#R&d engineer jobs near me for freshers#R&D Engineering Jobs#research and development mechanical engineer
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An engineer.
#We need engineers.#vintage illustration#engineers#engineering#science#math#technology#petroleum engineer#civil engineer#chemical engineer#computer engineer#electrical engineer#r&d#research & development#research#industry#mechanical engineer#biomedical engineer#aerospace engineer#vintage books#american industry
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Art and Science of Crafting Effective College Courses
In today’s dynamic educational landscape, the traditional methods of teaching and assessing are undergoing significant transformation. The tectonic shifts in technology and pedagogical research are compelling educators worldwide to rethink course designs, especially in higher education. At the heart of this transformation lies the quest to understand how students genuinely perceive and interact…
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#Course Designs#Course Evolution#Crafting Effective College Courses#Early stage entrepreneurship#Educator Insights#Engineering#Entrepreneurship Development#Feedback Mechanisms#Higher Education#Innovation#Pedagogical Research#Quantifiable Outcomes#Student Engagement#Student Perception#Teaching#Teaching Transformation#Technology#Traditional Methods
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Unveiling the Potential of 3D Scanning in Reverse Engineering
In the realm of engineering innovation, the advent of 3D scanning has revolutionized traditional methodologies. Among its myriad applications, one particularly noteworthy domain is reverse engineering.
Enterprises worldwide are leveraging 3D scanning technologies to dissect and recreate intricate designs, breathing new life into legacy components and machinery. The process involves capturing detailed digital renderings of physical objects, which serve as blueprints for replication or enhancement.
In the heart of technological advancements, Yamunanagar Engineering Cluster stands as a beacon of ingenuity. Employing cutting-edge 3D scanning techniques, the cluster pioneers the restoration and optimization of industrial assets with unparalleled precision and efficiency.
Beyond restoration, 3D scanning facilitates product innovation, enabling engineers to analyze and enhance existing designs swiftly. It expedites prototyping, reduces time-to-market, and fosters a culture of continuous improvement.
As industries evolve, the fusion of 3D scanning reverse engineering propels progress, ushering in a new era of limitless possibilities and unparalleled innovation.
#Yamunanagar Engineering Cluster#mechanical testing laboratory#3d scanning reverse engineering#cnc precision testing services#robotic welding testing services#inspection equipment testing services#research and development solutions
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Japanese-German team build working boson-fermion engine
#neon genesis evangelion#nerv#quantum energy#research#science#physics#development#quantum#quantum mechanics#quantum engine#theoretical physics#engineering#theoretical engineering#engine#machines#energy
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Into You ♥️
Max Verstappen x Redbull Engineer! Reader
Oh baby, look what you've started, the temperature's rising and is this gonna happen? (Been waitin' and waitin' for you to make a move)
At 27, you've just been promoted to the role of Redbull's race engineer - a very impressive feat in motorsport for a young woman. There's just one issue though - you secretly had a massive crush on the driver you're meant to be guiding, Max Verstappen. Will you make it through the season before he catches on? (You hope so because goddamn, the HR team were a nightmare to deal with.)
Content includes: fluff, humour, Max and reader are simps for each other, sexual tension, pining, drunk confessions, 3.2k WC
Recently, you'd started having some issues at work. Okay, gun to your head, you'll admit it was more like a single issue - in the shape of a very attractive, 6 foot Dutch racing driver who occasionally had problems with anger management. Sure, it didn’t sound that bad, in fact, someone else would just sit back and enjoy the eye candy the F1 paddock provided! But to truly appreciate the full depth of your embarrassing problem, one needed to unpack all the lore behind it.
After graduating from a prestigious mechanical engineering master's program, you'd been ecstatic about getting to intern at Redbull's F1 racing team, department of aerodynamic design. You'd started working at the company at a very good time, because later that year, their top driver Max Verstappen claims his first WDC at age 24 - only 6 months your junior. A very impressive feat for such a young age - as you admire him from a distance in the garage workshop. And, super hot too, you thought cheekily, whoever wifed him up was sure to be a lucky woman.
Your own hard work hadn't gone unnoticed, and many higher-ups and sponsors alike were curious to see the team who had been behind the championship winning changes to the Redbull car. You'd risen very quickly in the ranks, from intern to permanent technical engineer and then last year to to the innovative research & development department, now involved directly with calling the big shots for what each version of the car would look like and coming face to face with Max for the first time in your career with Redbull.
Unlike the other drivers, Max was genuinely curious about your design process. The way he asked questions, thoughtfully listened to your long explanations and then would give you direct feedback about the exact issues he would have in the trial runs had made you flustered, especially from the full intensity of his blue eyes. No, seriously though, Shakespeare himself would have written poetry if he'd gazed into them. The TikTok creators certainly seem to agree, with all their ocean eyes edits. Not that you had any saved. Anyways, moving on-
You were on the quieter side but Max seemed to know just how to get through to you. It meant that your team had been able to design the most dominating car in F1 history - the RB23, and paired with Max Verstappen it was an unstoppable force, almost like you made it just for me, Max had said, smiling gorgeously at you like some GQ Sports model. You stared back at him incredulously, banana choc chip muffin halfway to your mouth, cause who the hell woke up looking like that, you two were wearing identical Redbull shirts but his looked like it had been personally tailored to fit that broad muscular chest and yours was giving oversized trash bag??
Honestly, you'd hoped that working in closer proximity would humanise him more and you'd lose this silly crush of yours the moment you saw him do some icky rich white boy move. Like maybe he’d donate to Donald Trump's anti vaccine campaign or say guys ���� Can’t go to Ibiza this weekend the yacht staff had an emergency, got caught in some Gulf war zone or something? Idk
But when he had knocked on your apartment door when you hadn't shown up to work in two days, and found you crying because your childhood dog had just been diagnosed with terminal cancer across the other side of the world and saying I’m sorry, I know it’s not that big of a deal, I’ll come back tomorrow I promise-
And instead of laughing like you’d expected, he’d cut you off, told you to pack a bag and then driven you all the way to his personal jet. You looked into his beautiful blue eyes while he earnestly begged you to use it so you could make it in time to say goodbye to your Arlo before your parents put him down tonight. And that’s when you realised you were doomed to be hopelessly in love with the younger man. (But also, you had a serious discussion with him about the extreme greenhouse gas emissions from private jet fuel use, we only had one planet, you would be happy to just fly first class instead-)
But when your mentor Newey announced his plans to leave Redbull this year, you had planned on following him - making the exec panic at the thought of losing two of their crucial engineers. They frantically thrown random promotions at you, praying one would stick - and Redbull twitter fans breathed a sigh of relief when you took interest in the role of race engineer and stayed in the company.
You'd been excited about becoming one of Checo's engineers, having trained under the current one for the last few months. But to your horror, one day you arrived on the paddock only to be promptly sat down at a meeting along with the two drivers and be informed that they'd had to switch some things around, GP had an emergency to attend and could you pretty please fill in for the role of Max's race engineer this weekend-
NOPE. You'd announced, standing up and slamming your hands on the table, then realising that might be a touch overdramatic as everyone questioningly looked at you. Why not? Christian Horner demanded suspiciously.
Um, because he's super hot, you fool?! How is a girl meant to focus with him whispering track feels really wet today in her headphones? Were the years of self control to just admire from a distance like a loser and not jeopardise your career just a joke to him?? You don’t blink as your boss stared you down, hoping he could pick up on the thoughts that you’re trying to telepathically communicate. The table remained silent, only interrupted by the noisy slurping of Checo's boba tea. You quickly changed tactics - well, Verstappen is the winning champion, he needs an engineer who has experience working alongside him during the race-
Alas, the object of your affections threw a well intended wrench in your escape plans by adding that you were the perfect person, then, since you'd worked together for years and understood his communication style. Unless - he paused, flashing those deadly baby blues at you - unless the issue is you don't want to work with me?
You'd lasted all of three seconds under his hurt gaze before admitting defeat and accepting the role, slumping down next to him and desperately praying you'd wake up a lesbian tomorrow morning. Max continued to sneak long glances at you through the meeting, leaning around you to grab a pen and then his phone and making you jump each time his strong arm wrapped around your small frame. Across the table, Checo thoughtfully chewed on his boba as he watched you two curiously. Ah, young love.
And to no one's surprise the pair of you had made a flawless team, you expertly guiding Max as your engineer instincts took over and him actually listening to your helpful instructions without his usual aggression over the radio. And so when GP announced that his 1 week emergency was now going to be a 6 month break, sorry! - it had been all too easy for Christian Horner to bestow the honour of being Max's primary engineer onto you.
So now, here you sat, before your 4th race with Max, grimly looking on with your chin propped onto interlaced fingers, preparing yourself for his deep, sexy voice that was going to be purring in your ears very soon. The very voice that had become a recurring theme in the dreams you'd been having lately, that and also how he would bite those thick lips of his when he'd stare at you, with his cute little freckle on his top lip-
Why do you look like you're about to go to war, your intern asks bluntly, putting an end to your illicit thoughts and delivering you your triple chocolate caramel frap. Because I am, you hissed, sculling the whole thing in one go. She smirked, leaning in conspiratorially. Was this to do with how categorically down bad you are for your precious Maxie?
You proceeded to inform her that if she ever brought up how you'd drunkedly referred to him that one time, you'd have no problem abusing your authority to shaft her on tire service duty for a week. She wisely chose to leave you be in peace, taking your empty cup as she went.
Taking some meditative breaths, you focus on thinking about unsexy things. Like the hydraulics system of the current car needing to be redesigned to better incorporate-
Your thoughts are cut off a second time as another cup is deposited in front of you, this time by none other than Max himself, who's thoughtfully brought you a triple chocolate caramel frap. You stutter out your thanks, not daring to touch more caffeine currently as you already had sweaty palpitations at the sight of him looking so big and muscled in his slutty tight fireproofs. Dear God, had he no shame? They needed to bring back the Victorian era and cover him up, he was going to distract everyone (mainly you.) He frowns slightly, leaning down to your height, and informs you that you didn't have to call him Verstappen, you know, Max is fine-
Wow. And then what would come next? Maxie? And then you asking him for his hand in marriage? No, no, absolutely not - you needed to maintain strict professional boundaries or risk him catching onto your massive crush and promptly be fired. You politely informed him that for the sake of public decorum and the rabid fangirls that were watching your every move as a young female engineer in proximity to their favourite drivers, that you would refer to him as Verstappen, or Mr. Verstappen if he preferred a more formal title?
He'd pouted those lush lips of his and reluctantly agreed that just Verstappen was okay, he supposed. But he much preferred hearing you call him Max, at least when there were no cameras around? What you had done in your past life to now be forced to resist such temptation, you would never know.
So the season went on, you two continuing to be a smashing success and a very popular internet pairing. Not that you'd been paying that much attention! Just a saved TikTok edit here and there of the time Max had called you schatje over the radio after blowing up about a tire malfunction. He’d then sweetly apologised the next lap when you remained unfazed and told him to sort his shit out, babes, Leclerc was right up his ass with a tire and DRS malfunction, yeah? (Twitter had gone crazy. Who knew Max Verstappen responded so well to a 5 foot, slightly older woman giving him orders over the team radio?! You’d instantly been accepted as a replacement for the beloved GP, original gentle domTM to the Dutch driver.)
And perhaps another saved edit of the time he had protectively held you in those big, strong arms of his, guiding your tiny figure through a massive media-frenzied crowd and whispered reassurances in your ear when you couldn’t breathe properly. Or the time he’d bitten a reporter’s head off with the ferocity of a lion after he suggested that as the first female race engineer, you’d acquired your new job through your…feminine wiles.
And maybe just one of when the PR team had made you do one of those ridiculous hot lap videos with him after seeing the online response, and he'd laughed as you screamed out of fear for your life when he cruised at a cool 200km/hr. The aftermath had been brutal, as you weakly stumble out and almost fall flat on your face, only for him to easily pick you up, carrying you bridal style back towards the garage (Truly, this right here was proof God sent his hardest battles to his strongest soldiers.)
Nearing the end of the 6 month stint, when GP was due back in to resume his role as Max's race engineer, the Redbull team had decided to take a well deserved weekend trip to Verona, Italy. You’d suspiciously looked at your intern, asking why she’d selected the romantic setting of Romeo & Juliet of all places, to which she replied that just cause you’d chosen to cockblock yourself for eternity with a crush on your coworker the millionaire F1 driver, didn’t mean the rest of them couldn’t get some. Valid point, so you shut up.
So now, here you are, sitting in a romantically lit corner of a cute Italian vineyard with a small group from the engineering division, sloshed after a bottle of red wine and asking them be real, be real, you're telling me none of you have been checked out Max's ass in his fireproofs? Lies.
Across the courtyard, Lando is currently extremely unimpressed with his good friend, 3 time Championship winning, and general terror on the track Max Verstappen. That is because said friend has decided, rather pathetically, to lie on the cobblestone and drunkedly ask the stars why fate was so cruel. Seriously mate, Lando sighs, all this over a silly insta post?
Excuse you, it’s not just any insta post! Max had protested, baby tears in his eyes and face flushed from the four G&Ts he’d drunk. Pulling out his phone, he shows Lando the damning evidence of the pictures you'd uploaded from the group trip with your engineering friends. Look. LOOK. His arm is around her and she used a Lana Del Ray lyric in the caption. Do you have any idea what this means?
The Brit has to resist rolling his eyes at the melodrama unfolding in front of him. The Dutchman continues, never one to miss a chance to maxplain - as he details how it had taken him a a whole 2 months to get him to call you by his first name, and then another 2 months before you'd told him your favourite song was Summertime Sadness, and that even now if he hugged you to celebrate a win you would look like you were about to throw up and furiously speed walk away.
Lando is seriously regretting tagging along to the Redbull trip instead of Carlos's invitation to Mallorca. It was bad enough that the whole train ride Max had been on the phone begging GP to take another 6 month break so that you'd continue to be his engineer, but Lando has had his limit with this simpy pining. Taking his phone out as the maxplaining continued in the background, he shoots a text to your intern, who immediately replies, and within minutes the pair of them have hatched a conniving plan to dump you lovesick fools together while the rest of them make their way into town.
And that’s how you and Max find yourself locked inside the upstairs wine cellar, having been separately tricked with various promises from your scheming friends - only to hear the door click behind you and turn to find each other. It's very romantic and all, soft candlelight and bottles of luxurious Italian wine and a shining full moon visible from the terracotta balcony. Someone had even generously left a speaker in the courtyard, with Lana Del Ray's melodic voice rising upto the second floor. Basically, the worst nightmare for your self control as you prayed for inner strength and avoid looking into Max's dreamy blue eyes. This was definitely some twisted beyond the grave revenge from Shakespeare for you saying he'd write poetry about a F1 driver’s eyes.
Max, though, is all too happy to come right over to you with another freshly opened bottle of wine, drunk and flushed and having zero inhibitions about pulling you into his warm side with a strong arm. You're too buzzed to resist, letting yourself fall against his chest to hear his soothing heartbeat and rest a palm against his hard abs, just this once (The real thing was even better than what you'd imagined.)
You're both laughing and giggling then, hearts full, reminiscing about the season together, the inside jokes on the radio, the side eyes to each other when Horner got too wound up at a meeting, and oh did you hear that the McLaren tireboy was hooking up with the Mercedes oilchecker?
And then your eyes meet his and your homegirl Lana starts singing dear lord when I get to heaven, please let me bring my man (real) and Max is softly brushing your cheek, leaning down as your heated gazes flit to each other's lips-
NOPE! you force yourself to declare, dramatically leaving his arms and contemplating if you could land the jump from the 2nd floor balcony. The Italian wine has made Max demanding though, as he doesn't let you go, grabbing your hand to pull you back like he was Anthony goddamn Bridgerton and wanting to know Why not, was he just imagining the chemistry, did you not find him hot or?
You'd gaped at him. Not hot? Apparently the Italian wine had gotten to you too because you didn't hold back, launching into a tirade of how no, Max, the issue was actually that he was too hot for his own good and did he even know how unfair it had been to be his engineer, pure torture really, you were sure the American military would be adding it to their interrogation tactics. As if it hadn't been bad enough to crush on him from a distance for years but then have to resist falling for him every time you saw him? So, no, you couldn't just give him a casual drunk kiss because you were in love with him!
Max stares at you, initially smug that you apparently found him so irresistibly good looking, but now completely bewildered when you finished ranting. You think - he swallowed. You think that this is just casual? Cause I- cause I'm drunk?
At your nod, he launches into his own maxplaination, brows furrowed, demanding to know how on earth you could think it was just casual, what about when he diligently showed up to every meeting with a banana choc muffin and caramel frappe and his hoodie for you to wear on the chilly mornings, or when he brought two Lana Del Ray VIP tickets the very same day you'd told him you liked her, or when he'd literally called you darling in Dutch over the team radio for the whole world to hear, or how he even sold his private jet and only jetpooled with the others since you told him off?! Seriously, even that old crone Helmut had asked him when you two were going to hard launch!
Your doe eyes go wider and wider at each statement, a pretty flush taking over your own face as your mind boggles at the realisation that apparently, the love of your life felt just as deeply about you. Stuttering, you try to formulate a reply - only to come up with Oh, well, I, uh - you sold your jet? For me?
Max rolls his eyes, but there's nothing except pure adoration on his face as he pulls you back into his warm chest, grinning down at you when you eagerly wrap your arms around his broad shoulders. Yes, schat, he murmurs gently, the cutest blush painting his cheeks. Because I love you, too. And this time you don't pull away when he finally, finally leans down and meets your lips in a passionate kiss, enjoying the sweet moans he draws out of you as he showcases his numerous talents off the track.
Somewhere, in the middle of a Verona nightclub, your intern gives Lando Norris a firm handshake. Pleasure doing business with you.
_____________________________________________
A/N: A lil sweet fluff for me, this is actually my first fluff piece i think ahaha i've only written like 8 smut pieces in a row!! Hope you enjoyed 💖 and PS thank you ALL for the requests you’ve been sending, been getting them and will work thru them just have a few projects I’m cookin up for u guys hehe xx
#max verstappen fanfic#max verstappen imagine#max verstappen x reader#max verstappen x you#max verstappen#f1 fanfic#f1 imagine#formula 1
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Teksun Inc is an ISO 9001:2015 certified IoT and AI Solutions Company specializing in Product Engineering Services supporting ODM & OEM for numerous B2B Applications & Use Cases. To know more about browse: https://teksun.com/ Contact us ID: [email protected]
#Product design#Prototyping#Manufacturing#Product development#Research and development#Industrial design#Mechanical engineering#Electrical engineering#Software engineering
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A CAREER IN MECHANICAL ENGINEERING
Mechanical engineering is considered as the mother branch of engineering. This branch of engineering offers a combination of engineering physics and mathematics principles combined with designing, analyzing, manufacturing, and maintaining mechanical structures like machines, tools, and engines. Mechanical engineering is one of the oldest and wide-ranging branches of engineering.
What is mechanical engineering?
In simple terms, mechanical engineering is the study of motion, force, and energy. A mechanical engineer is responsible for creating technologies that meet human needs. A mechanical engineer works in the branches of research, development, designing, and has roots in the application of technologies.
It won’t be puffery if we categorize mechanical engineering as one of the safest braches for the career in engineering
MECHANICAL ENGINEERS works on the principle of “how to make things Works”! There are different fields in which mechanical engineers can work :
Manufacturing: mechanical engineers are responsible for the manufacturing of machines and instruments related to various industries such as the automotive industry, oil and gas industry, air conditioning and refrigerator industry, etc. Mechanical engineers basically involved in the industries that produce mass products.
Product designing: mechanical engineers are responsible for designing and monitoring of the product designed for various industries to suits the present requirement of the consumer.
Research and development: mechanical engineers also involve in the research and development of the products and services that satisfy the need of society. They may get involved in the research of pieces of equipment in armed forces, aerospace machinery, etc.
System monitoring: mechanical engineers are responsible for the monitoring of large systems. Mechanical engineer works under section for airplanes, air conditioners, car engines, induction motors, transformers, and whatnot.
The main function of a mechanical engineer will be problem-solving, designing, manufacturing, and functioning of the various projects involving machines.
#work#career#development#research#engineering#energy#like#manufacturing#projects#oilandgas#engineers#society#mechanicalengineer#mechanical#mechanicalengineering#aerospace#automotiveindustry#mathematics
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| DEMO | RO INTROS |
| pinterest | playlists |
Welcome back to Misty Cove!
Your hometown that holds all of your best memories from childhood. Days where you spent all of your time with friends, exploring and playing. The most notable thing about both you and your hometown however, is what started happening in your teenage years. After you and your friends uncovered a mystery about the high school you all went to, you starting finding more odd occurrences across the county, and well, it's not like anybody else was going to solve them.
You and your friends because a team of detectives. Most your teenage years and early twenties were spent solving odd crimes across the country. You were all best friends.
That was until four years ago when...
Well, you're not sure you can remember anymore.
It doesn't matter right now. Welcome back.
'Return to Misty Cove' is a horror/mystery Interactive Fiction game that is inspired by Scooby-Doo, Soul Reaver, and the works of H.P. Lovecraft. This work will be rated 17+ for gore, violence, swearing, death, body horror, and possession that might not be suitable for everyone.
Customize your MC's appearance (gender, height, body type, ect.) develop their personality and become the linchpin of your mystery solving team.
Find out more and possibly solve the mystery that has been haunting your hometown.
Rekindle, or destroy old friendships (and maybe develop romances) with your former team, and meet others along the way.
Have an animal companion! (dog or cat)
Major Characters
Cameron "Cam" Morris (M/F) [RO]- Tech-savvy and mechanically minded, Cam is currently working as a mechanic after you and your group broke up, they are currently going to grad school for mechanical engineering, and still sends postcards and pictures to you. They are likely the sweetest person you have ever met, even if sometimes they are too kind to people who don't deserve it. Out of the four of you, Cam was always the one who needed to do what was right, no matter the cost, and even if what they thought was right at the time hurt in the long run.
Ollie Cohen-Reyes (NB) [RO]- Ollie has always been interested in macabre and strange, spending hours researching in the library any and every topic they were interested in. They get along with very few people, but once they are able to get close with others it becomes easier, and they become sarcastic and witty, and feel less uncomfortable talking about their interests freely. They work as an adjunct professor in forensic anthropology.
Rose/Rory Thompson(M/F) [RO]- They are a loyal person, first and foremost. When the group broke up they somewhat lost their purpose, but they ended up settling and working as a bartender in Misty Cove. Having taken boxing and self-defense classes from a young age due to their paranoid parents, R was always the best when it came to physical confrontation with the cases you investigated, even if outside of this they never seemed like someone who had that much power. They have become far more aggressive and assertive than the person you knew as a child, now having the attitude to match their technical know-how.
Terra Clarke (F) [RO]- You originally knew her by a different name, but she started transitioning early on life, and Terra is the only name you can remember now. Normally when you say it it's followed by a nasty comment. Terra was never someone you got along with when you lived in Misty Cove. She was antagonistic towards you and your friends, but a lot has changed since the last time you saw her. She now owns her Grandpa's diner, and tries to take good care of the people of the town, especially since the mayor won't do much. She is always exhausted now, but is very happy to see a familiar face, even if your history is muddied because of both of your actions.
Randall 'Randy' Clarke - Terra's grandfather and former owner of "Randy's Diner" always very kind to you and your friends, even if you all never got along with Terra. He has been running his diner since the 60's and has faith that his granddaughter will uphold the legacy.
Ana Lloyd - (An-uh) the mayor of the town of Misty Cove. Trying to "restore the former glory of the town" as if she didn't move here less than 2 years ago, and was the only person who ran when the former mayor died while in office. She has been selling some of the old public spaces to business developers as a way to "expand the town and bring in new people".
Mrs. Ms. Emerson Talbot- Your former English teacher from high school, you never got along with her that well. She, now in her 70's has only gotten more bitter. You just hope she doesn't hold grudges.
Dorothy Giles- Your co-worker, likely the only one in your office who has a soul anymore. A woman who would go to the ends of the earth to protect the people she cares about, even if those people are just 20-somethings that she has taken under her wing.
(Things are subject to change throughout the games development)
#interactive fiction#interactive novel#intro post#misty cove-if#if wip#twine if#second try for the intro post#I learned how to code to make this game out of spite#misty cove if
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"In a first-ever human clinical trial, an mRNA cancer vaccine developed at the University of Florida successfully reprogrammed patients’ immune systems to fiercely attack glioblastoma, the most aggressive and lethal brain tumor.
The results in four adult patients mirrored those in 10 pet dog patients suffering from brain tumors whose owners approved of their participation.
The discovery represents a potential new way to recruit the immune system to fight treatment-resistant cancers using an iteration of mRNA technology and lipid nanoparticles, similar to COVID-19 vaccines, but with two key differences: use of a patient’s own tumor cells to create a personalized vaccine, and a newly engineered complex delivery mechanism within the vaccine.
“Instead of us injecting single particles, we’re injecting clusters of particles that are wrapping around each other like onions,” said senior author Elias Sayour, M.D., Ph.D., a UF Health pediatric oncologist who pioneered the new vaccine, which like other immunotherapies attempts to “educate” the immune system that a tumor is foreign.
“These clusters alert the immune system in a much more profound way than single particles would.”
Among the most impressive findings was how quickly the new method spurred a vigorous immune-system response to reject the tumor, said Sayour, principal investigator at the University’s RNA Engineering Laboratory and McKnight Brain Institute investigator who led the multi-institution research team.
“In less than 48 hours, we could see these tumors shifting from what we refer to as ‘cold’—very few immune cells, very silenced immune response—to ‘hot,’ very active immune response,” he said.
“That was very surprising given how quick this happened, and what that told us is we were able to activate the early part of the immune system very rapidly against these cancers, and that’s critical to unlock the later effects of the immune response,” he explained in a video (below).
Glioblastoma is among the most devastating diagnoses, with median survival around 15 months. Current standard of care involves surgery, radiation and some combination of chemotherapy.
The new report, published May 1 in the journal Cell, is the culmination of seven years of promising studies, starting in preclinical mouse models.
In the cohort of four patients, genetic material called RNA was extracted from each patient’s own surgically removed tumor, and then messenger RNA (mRNA)—the blueprint of what is inside every cell, including tumor cells—was amplified and wrapped in the newly designed high-tech packaging of biocompatible lipid nanoparticles, to make tumor cells “look” like a dangerous virus when reinjected into the bloodstream to prompt an immune-system response.
The vaccine was personalized to each patient with a goal of getting the most out of their unique immune system...
While too early in the trial to assess the clinical effects of the vaccine, the patients either lived disease-free longer than expected or survived longer than expected. The 10 pet dogs lived a median of 4.5 months, compared with a median survival of 30-60 days typical for dogs with the condition.
The next step, with support from the Food and Drug Administration and the CureSearch for Children’s Cancer foundation, will be an expanded Phase I clinical trial to include up to 24 adult and pediatric patients to validate the findings. Once an optimal and safe dose is confirmed, an estimated 25 children would participate in Phase 2."
-via Good News Network, May 11, 2024
youtube
-video via University of Florida Health, May 1, 2024
#cw cancer#cw death#cw animal death#medical news and technology#cancer#brain cancer#cancer treatment#tumor#brain tumor#florida#university of florida#medicine#biology#cell biology#mrna#mrna vaccine#vaccines#oncology#good news#hope#Youtube
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Potential DPxDC Fic 6
Guess it could be just DP. I just like DPxDC. It's a Bad Fenton Parents fic, but based on me reading about various new forms of child abuse to use. CW below for childhood neglect and stuff.
Danny is born into the Fenton family after Jack and Maddie lose their beloved Jasmine to The Stystem. Taken from their home and placed in foster care for small things like forgetting to get her lunch perfectly on time (or every day after a breakthrough) or getting behind on laundry for awhile (after spending a week backing up their research in case of a ghost or EMP strike. Its not like they managed time to bathe or change clothes, either!). They wouldn't make the same mistake as they would with their lovely daughter. Instead of announcing the pregnancy, they kept quiet. Maddie stayed home so the neighbors didn't see her growing belly. When the birth came, they delivered at home (a biology degree is good enough!), and vowed to home school him so he would stay and not be taken away. The homeschooling didn't...end up with the same results as traditional school. They were both still busy closing in on their portal, after all, so lessons were usually sporadic and centered around their work. Danny definitely had the Fenton Genius (TM) from how he picked up advanced physics, calculus, mechanical engineering and mathmatics. He still wasn't great at reading regular words or writing, but his numbers are neat and his calculations flawless, so things like English and History could sit on the side. It was sad, of course, how Danny was stuck in the home for the sake of the family, the curtains permanently drawn to avoid the nosy neighbors that tore apart their family before, but instead of moping or rebellion, he worked alongside them as soon as he could. Maddie framed his first hazmat suit, gifting him a new one with each growthspurt, always white ("We'll let you pick your own Fenton OSHA Approved Hazmat Color once you grow up, Danny."), and he stood with his parents as they tried to open the portal when he turned fourteen. And it failed. Dejected, all three left and ate the planned celebratory fudge with sullen expressions, the fudge itself feeling overly tacky with their depression. Danny, however, got up in the middle of the night and snuck into the basement, his steps smooth and confident even in the darkness of the house (he could get anywhere in the house with his eyes closed). He crept into the basement, an idea striking him. There was an auxillary power button inside the portal itself, meant as a backup or last resort override. However, Danny knew his dad installed the electrical system overnight one night in a fit of manic inspiration. What if it wasn't the auxillary power button anymore? He slipped on his hazmat suit. He walked into the portal, double checked the wiring, and looked up at the button, red and obvious in the wall. If he was correct, he thought as he raised his hand to the button, all he had to do was-
Jack and Maddie raced down the stairs as the lights flickered and a faint cry rose from below. In the basement they found Danny in his hazmat suit. He stared at them with frightful shock, his hair and left hand singed, then turned toward the humming that enraptured his parents as soon as the descended. The portal was working. It worked! Jack and Maddie and Danny were all elated, but Danny began to recede from their work. Stating he wanted to journal their portal research and development into a story, he began to hide in his room more and more. He ordered and read books on biology, psychology, even philosophy, because he knew what happened to him. The portal opened on him, and he died. He awoke in the basement as a ghost, barely transforming himself into something human looking before his parents arrived. However, what he thought he felt went against everything he knew about ghosts. Ghosts weren't sentient. They were emotions strongly imprinted on ectoplasm. Enough ectoplasm or emotions and an echo of those dead feelings rose, taking on an avatar and acting purely off the instinct of the moods that made them. Considering ectoplasm usually manifested with death, and the strongest emotions of the dying are usually fear and anger, most ghosts were destructive with no care for property or life, mindless monsters who'd tear apart the mortal world if left to their own devices in a vain attempt to soothe their undying emotions. But Danny still felt like Danny. He had thoughts, emotions, physical feeling, everything like when he was...when the portal wasn't open. Research, thankfully, taught him what happened. After all, signs were there that something changed for the worse in him. He felt afraid of his parents, and he'd begun lying to them daily when he could never remember telling a fib. On top of that were the strange new powers he couldn't control and shapeshifting abilities between himself and some ghostly manifestation of himself. The portal changed him. He wasn't Danny the Human anymore, but he wasn't a typical ghost, either. Danny was a Philosophical Zombie, and he had no idea how he's gonna tell his parents.
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Tony Stark really is the chosen one
he's a prodigal son he's a child wonder he's a genius he's the boss he's the ceo he's the engineer he's the researcher and the developer he's the kidnapped prince of a multi-million dollar company he's built it in a cave with a box of scraps he's iron man he's dying from the thing that's keeping him alive he's a mess he's barely holding it together he discovered an element in his garage he thinks he did okay he's become as expert in astrophysics last night he's an alien chewtoy he's got a nuke and he knows where to put it he's got ptsd he's got anxiety he's got nightmares every night he's a man in a can and he's got to protect the one thing he can't live without he's a piping hot mess he's the mechanic he's got cheap tricks and cheesy one liners he's chained to a bed in a dungeon he's emotionally unstable he's got no suit he's got way too many suits he's trying to end the fight he wants to go home he's doing everything he can he's in a three piece suit he's okay he's okay he's always okay he's got backup in queens he's sad he's mourning he's beaten down broken he's tony stank he's the adult he's talking he's there and he listened he's bought that ring eight years ago he's engaged he's got a dinner reservation he's taking this fight to their turf he's bleeding he's bruised he's been stabbed with his own suit he's lost he's lost he lost the kid he's stranded in space he's sick he's dying he's playing silly games with his alien best friend he's crying he's not making it home he's lost the kid he's lost the kid he's lost the kid he's a husband he's a soft proud dad he's got his second chance right here he's going to sell all the toys he's figured out time travel overnight he's going to sink it to the bottom of the lake he's not going to be able to sleep he's going back in time he's messed it up he's got an idea he's fighting with all strength he has left he's hugging his kid and he. is. iron. man
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We need engineers.
#vintage illustration#engineers#engineering#science#math#technology#petroleum engineer#civil engineer#chemical engineer#computer engineer#electrical engineer#r&d#research & development#research#industry#mechanical engineer#biomedical engineer#aerospace engineer#vintage books#american industry
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Zap Energy says that they’ve solved Z-pinch by “shear stabilization”, where they have different sections of the plasma moving at different velocities (faster outside, slower inside). Doesn’t shear like that cause instability, not suppress it? Or are plasmas not subject to that law of fluid dynamics
You’re thinking of instabilities in flowing plasma like it’s turbulence in flowing fluid. This is partially correct, but like... okay. So, the field of physics that governs the movement of plasma is called magnetohydrodynamics, where you introduce Maxwell’s equations into Navier-Stokes. It is horrible. I am but a humble mechanical engineer, and I leave the physics to physicists.
The physicists tell me that Zap Energy's science is solid.
Bit of context: Zap Energy is taking an old fusion energy concept from the 1950's called a Z-pinch, and revamping it with modern plasma physics.
A Z-pinch works on the principle that passing an electric current through a conductor generates a magnetic field, which in turn crushes (or "pinches") the conductor. The first observations of the pinch effect were in hollow metal tubes that were used as lightning rods, like this one from a factory in 1905:
Image by Brian James, CC BY-SA 3.0, Wikimedia Commons
Plasma is electrically conductive, and is subject to the same compressive pinch effect as metal. Lightning itself is a plasma pinch, actually.
When you pinch a plasma, it heats up. The fast-moving, charged plasma particles repel each other and push back against the magnetic field until the system reaches equilibrium. The stronger the plasma current, the harder the pinch, the more pressure, and the more heat. With sufficient plasma current and the right hydrogen isotopes, you can create a pinch strong enough to induce nuclear fusion.
The pinch effect was first utilized by a class of fusion machines called Z-pinches in the early 1950's. However, those Z-pinches were extremely unstable. The most common analogy is that compressing plasma with a Z-pinch is like trying to squeeze jello with rubber bands.
UK Atomic Energy Authority, Public domain, via Wikimedia Commons
Both linear and toroidal Z-pinches have been built. The toroidal Z-pinch above shows some of the characteristic kink instabilities of a pinched plasma – it goes all squiggly. Researchers started adding external magnets to Z-pinches to help reduce instabilities (which eventually led to the development of the tokamak), but could never get a truly stable plasma. Z-pinch fusion research was largely abandoned in favor of the tokamak and stellarator.
However, the external magnets of a tokamak or stellarator are massive, complex, and use incredible amounts of power. The University of Washington and Zap Energy went back to the old concept of a magnet-less linear Z-pinch, but with a more modern understanding of plasma physics. They discovered that by using a flowing plasma rather than a stationary one, with a faster flow rate on the outer layers (a "sheared-flow" Z-pinch), they were able to achieve great stability with no magnets.
Credit: Zap Energy
Rather than filling a chamber with stationary hydrogen and then pinching it, they blow a "smoke ring" of plasma around a cylinder into their chamber. An electrode at the tip of the cylinder then fires a pulse into the plasma, which creates a pinch with a complex velocity profile.
Credit: Zap Energy
Zap Energy’s physics basis is good. They’ve pretty convincingly demonstrated that sheared-flow does indeed stabilize a pinched plasma, and if they can pull off magnetic confinement fusion with no magnets, it will be massively cheaper than any other method. The uncertainty that Zap is facing comes from mechanical considerations (in particular, electrode erosion is a tricky problem to solve), and the relatively thin margins for efficiency that are inherent to any pulsed fusion technique.
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Inspection Equipment Testing Services: Your Precision and Safety Experts
In industries, the growing competition requires optimum equipment operations that mark the paramount importance of precision and safety. This inspection equipment plays a crucial role in maintaining quality standards and preventing potential hazards avoiding any business disruption. For this reason, Inspection equipment testing services are essential for any business domain heavily dependent on machinery to ensure the accuracy and reliability of these tools.
We involve comprehensive quality checks and evaluation of various inspection tools, such as gauges, meters, scanners, and analysers, to verify their accuracy and functionality. These services are typically performed by specialized technicians who follow stringent testing protocols to test equipment on various parameters critical for the production process.
Importance of Inspection Equipment Testing Services:
Quality Assurance: Precise inspection equipment is crucial for maintaining product quality and process efficiency. It allows regular testing that guarantees that measurements will be accurate and consistent.
Safety Compliance: Industries like manufacturing, aerospace, and healthcare rely on inspection equipment for safety and compliance with best business practices. The correct functioning of devices through inspection reduces the risk of accidents and largely ensures adherence to regulations.
Cost Efficiency: Faulty inspection equipment can lead to flawed products, production downtime, and rework costs that can significantly hamper business image. Leveraging Inspection equipment testing services prevent these issues by detecting problems early, saving both time and money.
Data Integrity: Inspection equipment often generates crucial data that plays an important role in decision-making. If these instruments are inaccurate, it can lead to incorrect data conclusions which can be avoided by regular testing safeguards.
#Yamunanagar Engineering Cluster#mechanical testing laboratory#3d scanning reverse engineering#cnc precision testing services#robotic welding testing services#inspection equipment testing services#research and development solutions
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Diabetes is a condition in which the body produces too little or no insulin. Diabetics thus depend on an external supply of this hormone via injection or pump. Researchers led by Martin Fussenegger from the biosystems science and engineering department at ETH Zurich in Basel, Switzerland want to make the lives of people with diabetes easier and are looking for solutions to produce and administer insulin directly in the body. One such solution the scientists are pursuing is enclosing insulin-producing designer cells in capsules that can be implanted in the body. To be able to control from the outside when and how much insulin the cells release into the blood, researchers have studied and applied different triggers in recent years: light, temperature, and electric fields. Fussenegger and his colleagues have now developed another, novel stimulation method: they use music to trigger the cells to release insulin within minutes. This works especially well with “We Will Rock You,” a global hit by British rock band, Queen. To make the insulin-producing cells receptive to sound waves, the researchers used a protein from the bacterium E. coli. Such proteins respond to mechanical stimuli and are common in animals and bacteria. The protein is located in the membrane of the bacterium and regulates the influx of calcium ions into the cell interior. The researchers have incorporated the blueprint of this bacterial ion channel into human insulin-producing cells. This lets these cells create the ion channel themselves and embed it in their membrane.
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