#public aids

[mythicalcoolkid]

You don't wish your disability was worse or more visible, you wish your disability was taken seriously. Please stop confusing the two, I guarantee you would not get the support you need JUST by being more severe or more visible. Please listen to visibly disabled people when we tell you it isn't better on our side

[reasonsforhope]

"Since it was first identified in 1983, HIV has infected more than 85 million people and caused some 40 million deaths worldwide.

While medication known as pre-exposure prophylaxis, or PrEP, can significantly reduce the risk of getting HIV, it has to be taken every day to be effective. A vaccine to provide lasting protection has eluded researchers for decades. Now, there may finally be a viable strategy for making one.

An experimental vaccine developed at Duke University triggered an elusive type of broadly neutralizing antibody in a small group of people enrolled in a 2019 clinical trial. The findings were published today [May 17, 2024] in the scientific journal Cell.

“This is one of the most pivotal studies in the HIV vaccine field to date,” says Glenda Gray, an HIV expert and the president and CEO of the South African Medical Research Council, who was not involved in the study.

A few years ago, a team from Scripps Research and the International AIDS Vaccine Initiative (IAVI) showed that it was possible to stimulate the precursor cells needed to make these rare antibodies in people. The Duke study goes a step further to generate these antibodies, albeit at low levels.

“This is a scientific feat and gives the field great hope that one can construct an HIV vaccine regimen that directs the immune response along a path that is required for protection,” Gray says.

-via WIRED, May 17, 2024. Article continues below.

Vaccines work by training the immune system to recognize a virus or other pathogen. They introduce something that looks like the virus—a piece of it, for example, or a weakened version of it—and by doing so, spur the body’s B cells into producing protective antibodies against it. Those antibodies stick around so that when a person later encounters the real virus, the immune system remembers and is poised to attack.

While researchers were able to produce Covid-19 vaccines in a matter of months, creating a vaccine against HIV has proven much more challenging. The problem is the unique nature of the virus. HIV mutates rapidly, meaning it can quickly outmaneuver immune defenses. It also integrates into the human genome within a few days of exposure, hiding out from the immune system.

“Parts of the virus look like our own cells, and we don’t like to make antibodies against our own selves,” says Barton Haynes, director of the Duke Human Vaccine Institute and one of the authors on the paper.

The particular antibodies that researchers are interested in are known as broadly neutralizing antibodies, which can recognize and block different versions of the virus. Because of HIV’s shape-shifting nature, there are two main types of HIV and each has several strains. An effective vaccine will need to target many of them.

Some HIV-infected individuals generate broadly neutralizing antibodies, although it often takes years of living with HIV to do so, Haynes says. Even then, people don’t make enough of them to fight off the virus. These special antibodies are made by unusual B cells that are loaded with mutations they’ve acquired over time in reaction to the virus changing inside the body. “These are weird antibodies,” Haynes says. “The body doesn’t make them easily.”

Haynes and his colleagues aimed to speed up that process in healthy, HIV-negative people. Their vaccine uses synthetic molecules that mimic a part of HIV’s outer coat, or envelope, called the membrane proximal external region. This area remains stable even as the virus mutates. Antibodies against this region can block many circulating strains of HIV.

The trial enrolled 20 healthy participants who were HIV-negative. Of those, 15 people received two of four planned doses of the investigational vaccine, and five received three doses. The trial was halted when one participant experienced an allergic reaction that was not life-threatening. The team found that the reaction was likely due to an additive in the vaccine, which they plan to remove in future testing.

Still, they found that two doses of the vaccine were enough to induce low levels of broadly neutralizing antibodies within a few weeks. Notably, B cells seemed to remain in a state of development to allow them to continue acquiring mutations, so they could evolve along with the virus. Researchers tested the antibodies on HIV samples in the lab and found that they were able to neutralize between 15 and 35 percent of them.

Jeffrey Laurence, a scientific consultant at the Foundation for AIDS Research (amfAR) and a professor of medicine at Weill Cornell Medical College, says the findings represent a step forward, but that challenges remain. “It outlines a path for vaccine development, but there’s a lot of work that needs to be done,” he says.

For one, he says, a vaccine would need to generate antibody levels that are significantly higher and able to neutralize with greater efficacy. He also says a one-dose vaccine would be ideal. “If you’re ever going to have a vaccine that’s helpful to the world, you’re going to need one dose,” he says.

Targeting more regions of the virus envelope could produce a more robust response. Haynes says the next step is designing a vaccine with at least three components, all aimed at distinct regions of the virus. The goal is to guide the B cells to become much stronger neutralizers, Haynes says. “We’re going to move forward and build on what we have learned.”

-via WIRED, May 17, 2024

[b0tster]

keanu has been seen supporting**** zionists its so fucking over 😞 i stg every time i end up with a main stream opinion i get kicked in the gut. gdi.

[izzystizzys]

There is a scratch mark on the floor of the Council chambers that Mace has never noticed before. Not a deep one, mind, quite shallow. This matters because it’s making the white-hot pulse of agony stabbing through his eyeballs ebb momentarily. Then, he chances a glance upwards at the fidgeting Knight in front of them, and it returns in full force.

Huh, he’s never seen Oppo Rancisis’ face turn that colour before.

“Hmm”, Master Yoda hums, deep and scratchy. His expression is unreadable even to Mace beyond a baseline gremlinness, and the force with which he grips the edges of his seat is making his bones creak. Master of the Order you should become, they said. Follow the calling of the Force, you should. A fulfilling purpose, it will be. Mace is going to hunt the little goblin for sport when this is all over, and he’s going to laugh the whole time.

“Show us the livestream again, could you, Knight Parvo?” Yoda asks. Mace bursts a capillary, he’s pretty sure, and so does poor Knight Parvo, whose orange Mon Cala skin tips all the way into blood red with stress. “Most unusual, this is.”

“Absolutely not!”, Ki Adi intervenes before Mace has to, thank the Force for little mercies. Plo Koon’s tusks tremble slightly with either suppressed laughter or abject horror, maybe both, and Stass Allie has her head in her hands. “The holo stills should be enough”, Ki Adi proceeds to add, and Mace has to reconsider all feelings of grace he just felt towards his fellow Councillor.

He never wants to watch Yoda zoom in on someone’s abs again. Or Depa raise her eyebrows at the curve of thighs bent over the dripping front of a speeder.

“Speeder Wash For Our Troops”, his former padawan reads out loud from a still of what has to be hundreds of the things gathered in the public senate parking lot. “Fund Our Boys And Get A Wet Seeing-To!” The series of images features dozens of Coruscant Guard troopers in various stages of unkitted, gleaming and shining with soap suds and water. The fact that the whole thing is also massive shatterpoint after massive shatterpoint is, quite frankly, insulting.

“Well hello- oh dear”, Obi-Wan’s blue form crackles to life in his chair, followed by several sounds of choking that are definitely not him. Good, Mace thinks acidly. If he has to deal with this, then so does kriffing Skywalker. “I’m sorry, why am I looking at Commander Thorn using a washrag like a lasso on top of a speeder?”

“Oh, the Guard’s little fundraising project”, Bail Organa says, as he steps into the Council chambers. Normally, Mace likes the man well enough. Now, he just smiles and adds on, “I’ve already donated, in mine and Breha’s name. Remotely, of course.”

“The Guard’s fundraising speeder wash?”, Obi-Wan repeats, edges of his holo form flickering with what Mace suspects is Skywalker very unsubtly trying to edge in. Force, but the man really is horrible at any and all stealth, like kissing his secret wife in an open arena in front of his Master. “And they are fundraising for…?”

“GAR budget allocations have to come from somewhere”, Organa shrugs. “And with the tide of public opinion turning, they’ve been tending towards cuts. The Guard feels them more keenly than any other sector - they’ve been reduced from half to quarter rations, and medical supplies have not made more than a token appearance in the last draft. The Chancellor has cancelled three consecutive meetings on the matter, and thus it was agreed that a more hands-on approach was needed. Any surplus will go into the Army fund.”

“Surely it can’t be that dire”, Oppo protests, a slightly less concerning shade of purple now. Senator Organa shrugs again, jostling the smattering of cracks slowly building around his person in a way that makes Mace wince quietly. “It’s all publicly available data, Masters.”

It really can be that dire, as it turns out. And quarter rations is only scratching the surface of how dire, considering the Guard has apparently never had access to bacta in all their posting, and also includes requisitioning forms available to the Senate for reconditionings and decommissionings, two words Mace has only heard Ponds whispers amidst shuddering in the early days of the war before Shaak Ti went off and just about tore some throats out over it.

“Alright”, he concedes, rubbing at his temples. “Fair enough, we have failed to tackle a massive blind spot in the Guard’s well being. There is no Jedi assigned to Coruscant, and that’s an oversight on our behalf. But how in the everloving kriff did this get past the Chancellor and Commander Fox?!”

Who have both signed, black on white. Bail Organa smiles cryptically. “Well, if you scroll a bit past that one image, up to the industrial speeder in the back - Commander Fox is currently having credits stuffed into his codpiece in the back, I believe.”

“HE’S WHAT IN THE WHAT NOW”, Commander Cody screeches through the speaker of Obi-Wan’s holo image, and Mace has to summon every bit of Jedi-serenity he possesses in his body to keep from dropkicking a cackling Yoda through the chamber windows.

[politijohn]

Source

[anna-scribbles]

13 y/o adrien agreste looked at his dumpster fire life and said “middle school would fix me” and he was right

[hiseyeisonthesparrow]

it's come to my attention that people on the internet REALLY do not know what a cult is. or how to do research.

[archie-sunshine]

SLACKERRRRRRR

p.s. tfa first aid is such a cutie it drives me insane. also don't talk to me about how i just did something like this with ratchet like twice

[justabunny]

PSA:

if someone who is using a mobility aid is trying to get on public transit first please just let them.

The other day I was trying to get on the public transit bus for my area, (which is primarily used for university students, but anyone can use it) and I usually stand at the front so I can be one of the first people to get on since I am a mobility aid user and use priority seating.

well, I was trying to get onto the bus and this guy tries to cut in infront of me and in the process bumps into me and makes me lose my balance and almost fall into other people.

if someone has a mobility aid usually it's safe to assume that they aren't the most stable on their feet, give them space and let them go first.

[marisatomay]

ppl dont assume tom cruise is in the closet like they used to

Like have we lost recipes this badly….there’s an entire chapter just on him in the David Ehrenstein book “Open Secret (Gay Hollywood 1928-1998)” … Gregg Araki openly called him the “Rock Hudson of the 90s” in Totally Fucked Up (1993) … he’s alleged to have worked at Studio 54 when he was 17 … he’s had pretty substantial gay rumors surrounding him since the early 80s including more than a few that have made their way into my DMs from people who knew … everyone should read the 1999 piece “Cruising Cruise”

[queer-crip-grows]

It is incredibly difficult to hear so many people in the environmental movement continually lionise trains as the answer to all transport needs.

Being a full time mobility aid user with chronic fatigue and sensory overload makes use of public transport nightmarish.

If *real* efforts were made to make every train and every station fully wheelchair-accessible, *without* having to rely on unreliable or downright abusive station staff to put ramps up and, down, it would be a fantastic *start*. On good days, I *might* be able to use it for certain kinds of journeys.

However, it still wouldn’t solve the issues with sensory overload, or the problems getting to train stations from my home due to severe chronic pain and chronic fatigue.

If overdo it when I’m out, I *crash*. I cannot expend all my resources getting places. I then cannot do anything when I am there, and am unable to get home safely.

This is not that uncommon a problem. My issues are due to hEDS, POTS and autism, but they are incredibly common symptoms of Long COVID and ME/CFS resulting from Long COVID. So, unsurprisingly, folk with these needs are becoming increasingly common as Covid continues to rampage through the population. *Some of us need transportation we have control over*, and we need environmentally sustainable options to do this.

While expanding the public rail network, making it completely affordable (or, realistically, free) and making it fully accessible for wheelchair and other mobility aid users, children travelling alone from about age 8, elderly people with limited eyesight and hearing and parents travelling with infants would be an *incredible* start and massively increase usage of public transport, there are those of us who will always need at least part-time access to vehicles which can come to our homes and that *we* have control over, that are just as affordable as public transport, and the environmental movement needs to acknowledge this, plan for it, and stop treating it as selfishness, laziness and all the other “fun” terms disabled folk face constantly just for trying to live, especially outside our homes.

This is going to be even more the case if you want us to be able to work outside our homes and if you continue to be resistant to providing fully remote jobs that pay a living wage.

[covid-safer-hotties]

Acquired Immune Deficiency Syndrome correlation with SARS-CoV-2 N genotypes - Published July 29, 2024

You read that right: Covid infections can result in AIDS. I've been following this preprint since 2022, and I'm so excited to see it finally published! You might remember the preprint from the original Milf-Adjacent or covidsafehotties blogs.

Highlights •Genotypes N/120 and N/152 of SARS-CoV-2 have been identified in the acquired immuno-deficiency scope caused by Sarbecovirus.

•A new binding site for the Sarbecovirus N protein is proposed as the main route of infection of lymphocytes through CD147 receptors.

•Immune dysregulation caused by infection of CD147 lymphocytes is consistent with clinical data of severe and Long Covid cases.

Abstract Background Epigenetics and clinical observations referring to Betacoronavirus lead to the conjecture that Sarbecovirus may have the ability to infect lymphocytes using a different way than the spike protein. In addition to inducing the death of lymphocytes, thus drastically reducing their population and causing a serious immune deficiency, allows it to remain hidden for long periods of latency using them as a viral reservoir in what is named Long-Covid Disease. Exploring possibilities, the hypothesis is focused on that N protein may be the key of infecting lymphocytes.

Method The present article exhibits a computational assay for the latest complete sequences reported to GISAID, correlating N genotypes with an enhancement in the affinity of the complex that causes immune deficiency in order to determine a good docking with the N protein and some receptors in lymphocytes.

Results A novel high-interaction coupling of N-RBD and CD147 is presented as the main way of infecting lymphocytes, allowing to define those genotypes involved in their affinity enhancement.

Conclusion The hypothesis is consistent with the mutagenic deriving observed on the in-silico assay, which reveals that genotypes N/120 and N/152 are determinant to reduce the Immune Response of the host infecting lymphocytes, allowing the virus persists indefinitely and causing an Acquire Immune Deficiency Syndrome.

Graphical abstract

[reasonsforhope]

Flint, Michigan, has one of the [United States]'s highest rates of child poverty — something that got a lot of attention during the city's lead water crisis a decade ago. And a pediatrician who helped expose that lead problem has now launched a first-of-its-kind move to tackle poverty: giving every new mother $7,500 in cash aid over a year.

A baby's first year is crucial for development. It's also a time of peak poverty.

Flint's new cash transfer program, Rx Kids, starts during pregnancy. The first payment is $1,500 to encourage prenatal care. After delivery, mothers will get $500 a month over the baby's first year.

"What happens in that first year of life can really portend your entire life course trajectory. Your brain literally doubles in size in the first 12 months," says Hanna-Attisha, who's also a public health professor at Michigan State University.

A baby's birth is also a peak time for poverty. Being pregnant can force women to cut back hours or even lose a job. Then comes the double whammy cost of child care.

Research has found that stress from childhood poverty can harm a person's physical and mental health, brain development and performance in school. Infants and toddlers are more likely than older children to be put into foster care, for reasons that advocates say conflate neglect with poverty.

In Flint, where the child poverty rate is more than 50%, Hanna-Attisha says new moms are in a bind. "We just had a baby miss their 4-day-old appointment because mom had to go back to work at four days," she says...

Benefits of Cash Aid

Studies have found such payments reduce financial hardship and food insecurity and improve mental and physical health for both mothers and children.

The U.S. got a short-lived taste of that in 2021. Congress temporarily expanded the child tax credit, boosting payments and also sending them to the poorest families who had been excluded because they didn't make enough to qualify for the credit. Research found that families mostly spent the money on basic needs. The bigger tax credit improved families' finances and briefly cut the country's child poverty rate nearly in half.

"We saw food hardship dropped to the lowest level ever," Shaefer says. "And we saw credit scores actually go to the highest that they'd ever been in at the end of 2021."

Critics worried that the expanded credit would lead people to work less, but there was little evidence of that. Some said they used the extra money for child care so they could go to work.

As cash assistance in Flint ramps up, Shaefer will be tracking not just its impact on financial well-being, but how it affects the roughly 1,200 babies born in the city each year.

"We're going to see if expectant moms route into prenatal care earlier," he says. "Are they able to go more? And then we'll be able to look at birth outcomes," including birth weight and neonatal intensive care unit (NICU) admissions.

Since the pandemic, dozens of cash aid pilots have popped up across the nation. But unlike them, Rx Kids is not limited to lower-income households. It's universal, which means every new mom will get the same amount of money. "You pit people against each other when you draw that line in the sand and say, 'You don't need this, and you do,' " Shaefer says. It can also stigmatize families who get the aid, he says, as happened with traditional welfare...

So far, there's more than $43 million to keep the program going for three years. Funders include foundations, health insurance companies and the state of Michigan, which allocated a small part of its federal cash aid, known as Temporary Assistance for Needy Families.

Money can buy more time for bonding with a baby

Alana Turner can't believe her luck with Flint's new cash benefits. "I was just shocked because of the timing of it all," she says.

Turner is due soon with her second child, a girl. She lives with her aunt and her 4-year-old son, Ace. After he was born, her car broke down and she was seriously cash-strapped, negotiating over bill payments. This time, she hopes she won't have to choose between basic needs.

"Like, I shouldn't have to think about choosing between are the lights going to be on or am I going to make sure the car brakes are good," she says...

But since she'll be getting an unexpected $7,500 over the next year, Turner has a new goal. With her first child, she was back on the job in less than six weeks. Now, she hopes she'll be able to slow down and spend more time with her daughter.

"I don't want to sacrifice the time with my newborn like I had to for my son, if I don't have to," she says."

-via NPR, March 12, 2024

[evilhorse]

AIDS public service announcement comic (circa February 1993)

[that-disabled-princess]

I don't care who the fuck you are, unless you're a member of my medical team, you are not entitled to my medical information.

[beranibear]

👏Your👏 baby👏in👏that👏foldable👏pram👏does👏not👏belong👏in👏the👏reserved👏wheelchair👏spot👏on👏the👏train👏when👏the👏train👏is👏packed👏and 👏people👏in wheelchairs👏are👏forced👏to👏just👏park👏👏their👏wheelchair👏in👏the👏middle👏of👏👏a👏walkway👏

You can literally fold the pram and hold your child.

Those spots are there so we are safe and out of the way. So we are able to get emergency help if needed via the emergency assistance button. So we don’t slide down the middle of the train or slam into people if it comes to a sudden stop.

I can not just fold my chair and get out of it. I don’t have the privilege or ability to do that. It is not a pram parking spot, the symbol on the floor and walls is not of a pram, it’s of the universal symbol for people with disabilities.

Wild how people will still do this when there is literally a sign stating that you will be fined if you don’t give up the spot. If your baby has mobility, if you have mobility; your pram was literally made to be folded and compacted. Please DO IT when the train is full and people with mobility aids are forced into spots that aren’t safe.

Fuck you. I should not have to be unsafe so you don’t have to fold a pram and hold your child.