#polycaprolactone

[acumenresearchandconsulting]

The Polycaprolactone Market Size accounted for USD 482.6 Million in 2022 and is estimated to achieve a market size of USD 1,327.6 Million by 2032 growing at a CAGR of 10.7% from 2023 to 2032.

[harshnews]

Polycaprolactone (PCL) Market Size, Share, Trends, Opportunities, Key Drivers and Growth Prospectus

"Global Polycaprolactone (PCL) Market' – Industry Trends and Forecast to 2029

Global Polycaprolactone (PCL) Market, By Form (Pellets, Nanosphere, and Microsphere), Production Method (Ring Opening Polymerization and Polycondensation of Carboxylic Acid), Application (Thermoplastic Polyurethane and Healthcare) – Industry Trends and Forecast to 2031.

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**Segments**

- **Application:** In terms of application, the PCL market can be segmented into healthcare, automotive, textiles, packaging, and others. The healthcare segment is expected to dominate the market due to the growing use of Polycaprolactone in the production of medical devices, drug delivery systems, and tissue engineering applications. The automotive segment is also anticipated to witness significant growth as PCL is used in the production of lightweight components, reducing fuel consumption and emissions.

- **End-Use Industry:** Based on end-use industry, the PCL market can be segmented into pharmaceutical, automotive, construction, and others. The pharmaceutical industry is a major consumer of PCL owing to its biocompatibility and biodegradable properties, making it ideal for medical applications. The automotive industry is also a key end-use industry for PCL due to its usage in manufacturing parts, components, and coatings.

- **Region:** Geographically, the global PCL market can be segmented into North America, Europe, Asia Pacific, Latin America, and Middle East & Africa. North America is expected to dominate the market due to the presence of key players and technological advancements in the region. The Asia Pacific region is also projected to experience substantial growth attributed to the increasing demand for PCL in various industries such as healthcare, automotive, and packaging.

**Market Players**

- Corbion - Perstorp

The key players in the Polycaprolactone (PCL) market include Corbion and Perstorp. Corbion is a leading supplier of biobased products, including PCL, catering to various industries such as healthcare and packaging. Perstorp is another prominent player known for its high-quality PCL products used in medical applications and other sectors. These market players are focusing on research and development activities to innovate new products and expand their market presence.

https://www.databridgemarketresearch.com/reports/global-polycaprolactone-pcl-marketThe Polycaprolactone (PCL) market is poised for significant growth across various segments and regions. In terms of applications, the healthcare segment stands out as a key driver for market expansion. The increasing utilization of PCL in the production of medical devices, drug delivery systems, and tissue engineering applications is propelling the growth of this segment. Additionally, the automotive sector is expected to witness substantial growth due to the lightweight nature of components produced using PCL, which aids in reducing fuel consumption and emissions. Moreover, PCL finds its application in textiles, packaging, and other industries, further diversifying its market reach.

When considering end-use industries, pharmaceuticals emerge as the largest consumer of PCL. The biocompatibility and biodegradable properties of PCL make it a preferred choice for medical applications within the pharmaceutical sector. Furthermore, the automotive industry also significantly contributes to the demand for PCL, utilizing it in the manufacturing of various parts, components, and coatings, thus driving growth in this particular segment. The construction sector and other industries also play a role in the uptake of PCL for diverse applications.

From a regional perspective, North America is expected to lead the global PCL market due to the presence of key market players and advancements in technology within the region. The well-established healthcare and automotive industries in North America further boost the demand for PCL in various applications. The Asia Pacific region is also set for substantial growth in the PCL market, driven by the increasing demand across industries such as healthcare, automotive, and packaging. The region's rapid industrialization and economic development are contributing to the rising adoption of PCL in different sectors.

Corbion and Perstorp emerge as prominent players in the PCL market, known for their high-quality products catering to diverse industries. Corbion's expertise in biobased products, including PCL, positions them as a key supplier to sectors like healthcare and packaging. Perstorp, on the other hand, is recognized for**Segments**

Global Polycaprolactone (PCL) Market, By Form (Pellets, Nanosphere, and Microsphere), Production Method (Ring Opening Polymerization and Polycondensation of Carboxylic Acid), Application (Thermoplastic Polyurethane and Healthcare) – Industry Trends and Forecast to 2031.

In the PCL market, various segments play a crucial role in driving growth and market expansion. The application segment is diverse, including healthcare, automotive, textiles, packaging, and others. The healthcare sector is anticipated to lead the market, fueled by the increasing use of PCL in medical devices, drug delivery systems, and tissue engineering applications. Similarly, the automotive segment is expected to experience significant growth due to the utilization of PCL in lightweight components, contributing to reduced fuel consumption and emissions. Moreover, the versatility of PCL extends to industries like textiles, packaging, and more, further expanding its market reach.

When analyzing the end-use industry segmentation, pharmaceuticals emerge as a major consumer of PCL, primarily due to its biocompatibility and biodegradable nature, making it ideal for medical applications. The automotive industry also plays a significant role in driving the demand for PCL, utilizing it in the manufacturing of parts, components, and coatings. Additionally, sectors such as construction and others contribute to the diverse applications of PCL, further enhancing its market presence across various industries.

From a regional perspective, North America is poised to dominate the global PCL

Key points covered in the report: -

The pivotal aspect considered in the global Polycaprolactone (PCL) Market report consists of the major competitors functioning in the global market.

The report includes profiles of companies with prominent positions in the global market.

The sales, corporate strategies and technical capabilities of key manufacturers are also mentioned in the report.

The driving factors for the growth of the global Polycaprolactone (PCL) Market are thoroughly explained along with in-depth descriptions of the industry end users.

The report also elucidates important application segments of the global market to readers/users.

This report performs a SWOT analysis of the market. In the final section, the report recalls the sentiments and perspectives of industry-prepared and trained experts.

The experts also evaluate the export/import policies that might propel the growth of the Global Polycaprolactone (PCL) Market.

The Global Polycaprolactone (PCL) Market report provides valuable information for policymakers, investors, stakeholders, service providers, producers, suppliers, and organizations operating in the industry and looking to purchase this research document.

Table of Content:

Part 01: Executive Summary

Part 02: Scope of the Report

Part 03: Global Polycaprolactone (PCL) Market Landscape

Part 04: Global Polycaprolactone (PCL) Market Sizing

Part 05: Global Polycaprolactone (PCL) Market Segmentation by Product

Part 06: Five Forces Analysis

Part 07: Customer Landscape

Part 08: Geographic Landscape

Part 09: Decision Framework

Part 10: Drivers and Challenges

Part 11: Market Trends

Part 12: Vendor Landscape

Part 13: Vendor Analysis

The investment made in the study would provide you access to information such as:

Polycaprolactone (PCL) Market [Global – Broken-down into regions]

Regional level split [North America, Europe, Asia Pacific, South America, Middle East & Africa]

Country-wise Market Size Split [of important countries with major market share]

Market Share and Revenue/Sales by leading players

Market Trends – Emerging Technologies/products/start-ups, PESTEL Analysis, SWOT Analysis, Porter’s Five Forces, etc.

Market Size

Market Size by application/industry verticals

Market Projections/Forecast

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[cosmicanger]

Emir Šehanović, Synthetic Attraction. Recontextualized art installation for Cu29 gallery (2023), originally presented at Space O+A Art Event – Tokyo, Japan. Polycaprolactone, artificial flowers, PVC fabric, neon tubes and aluminium pipes. Dimensions: 250cm x 130cm x 130cm

[materialsscienceandengineering]

Researchers use architected auxetics to achieve 300 times more flexibility in new 3D printing design

There are young children celebrating the holidays this year with their families, thanks to the 3D-printed medical devices created in the lab of Georgia Tech researcher Scott Hollister. For more than 10 years, Hollister and his collaborators have developed lifesaving, patient-specific airway splints for babies with rare birth defects. These personalized Airway Support Devices are made of a biocompatible polyester called polycaprolactone (PCL), which has the advantage of being approved by the Food and Drug Administration. Researchers use selective laser sintering to heat the powdered polyester, which binds together as a solid structure. Devices made of PCL have a great safety record when implanted into patients. Unfortunately, PCL has the disadvantage of having relatively stiff and linear mechanical properties, which means this promising biomaterial has yet to be applied functionally to some other critical biomedical needs, such as soft tissue engineering. How do you make a firm thermoplastic into something flexible, and possibly capable of growing with the patient? Hollister's lab has figured out how.

Read more.

[theaestheticedgeblog]

Hair Growth Treatment in Bangalore and Best Threads Treatment at The Aesthetic Edge

When it comes to advanced hair growth treatments and threads treatment in Bangalore, The Aesthetic Edge stands out as a leading name. Known for its commitment to excellence and client satisfaction, The Aesthetic Edge has become a trusted destination for individuals seeking effective and innovative aesthetic solutions.

Hair Growth Treatment Bangalore is one of the most sought-after services at The Aesthetic Edge. With increasing stress, pollution, and lifestyle changes, hair loss has become a common concern for many. At The Aesthetic Edge, specialized treatments are tailored to address individual hair loss patterns and scalp conditions. The clinic offers advanced therapies, including PRP (Platelet-Rich Plasma) treatment, mesotherapy, and laser hair stimulation, ensuring optimal results. The experienced team of experts uses state-of-the-art technology to stimulate hair follicles, enhance blood circulation, and promote natural hair regrowth. Every treatment plan is carefully crafted after a thorough consultation and analysis, making it highly personalized and effective.

In addition to hair growth treatments, The Aesthetic Edge is also renowned for offering the best threads treatment in Bangalore. Threads treatment is a minimally invasive procedure designed to lift and tighten sagging skin, resulting in a more youthful and rejuvenated appearance. The clinic specializes in both PDO (Polydioxanone) and PCL (Polycaprolactone) thread lifts, ensuring that clients receive the most suitable treatment based on their skin type and aesthetic goals. This procedure stimulates collagen production, enhances skin elasticity, and provides natural-looking results with minimal downtime.

At The Aesthetic Edge, client care and safety are of utmost importance. Every procedure is performed by highly qualified professionals who prioritize hygiene, precision, and client comfort. The clinic prides itself on using premium-quality products and maintaining international standards in all treatments.

What sets The Aesthetic Edge apart is its holistic approach to aesthetic care. The team believes in empowering clients by addressing their concerns with customized treatment plans that deliver sustainable results. Whether it’s restoring confidence through effective hair growth solutions or achieving a youthful appearance with threads treatment, The Aesthetic Edge ensures excellence in every service.

For individuals seeking reliable and effective hair growth treatment in Bangalore or the best threads treatment in Bangalore, The Aesthetic Edge remains a top choice. With cutting-edge technology, experienced professionals, and a client-focused approach, the clinic continues to redefine beauty and aesthetic care in Bangalore. Book your consultation today and take the first step towards enhanced confidence and natural beauty with The Aesthetic Edge.

[kaneinstitute]

Thread Lifts: Redefining Non-Surgical Rejuvenation in Medical Aesthetics

The world of medical aesthetics has witnessed a transformative shift toward minimally invasive procedures, offering clients effective solutions with little to no downtime. Among the most revolutionary advancements in this field is the thread lift, a technique that combines science and artistry to lift and rejuvenate the skin without the need for surgery.

For medical professionals, acquiring thread lift training is an invaluable investment that enhances their practice, meets growing client demand, and positions them as leaders in aesthetic innovation. This article delves into the fundamentals of thread lifts, the benefits they offer, and why mastering this skill is essential for medical practitioners in today’s competitive market.

What Is a Thread Lift?

A thread lift is a minimally invasive cosmetic procedure designed to lift sagging skin and stimulate collagen production. During the procedure, dissolvable threads made of biocompatible materials such as PDO (polydioxanone), PLA (polylactic acid), or PCL (polycaprolactone) are inserted beneath the skin. These threads provide an immediate lifting effect and encourage long-term collagen growth, resulting in firmer, more youthful-looking skin.

Advantages for Clients:

Instant Results: Lifting effects are visible immediately after the procedure.

Natural Rejuvenation: The collagen-stimulating properties of threads improve skin texture and elasticity over time.

Minimally Invasive: No large incisions, general anesthesia, or extended recovery periods are required.

Customizable Treatment: Thread lifts can address various areas of concern, including the face, neck, and body.

Long-Lasting Outcomes: Results typically last between 12 to 18 months, depending on the thread type and individual skin characteristics.

Popular areas for thread lifts include:

Cheeks and midface

Jawline and jowls

Neck

Brows and forehead

Nasolabial folds

The Growing Demand for Thread Lifts

The demand for minimally invasive procedures like thread lifts continues to rise, driven by clients seeking natural results without the risks or downtime associated with surgery. This trend has created a significant opportunity for medical practitioners to expand their expertise and capitalize on this growing market.

Why Medical Professionals Should Learn Thread Lift Techniques

Adding thread lifts to your service offerings can elevate your practice in numerous ways:

1. Attract a Broader Client Base

As more clients opt for non-surgical solutions, mastering thread lifts allows you to cater to their preferences and grow your client base.

2. Enhance Your Expertise

Thread lifts complement other aesthetic treatments such as dermal fillers, Botox, and skin tightening therapies, enabling you to offer comprehensive anti-aging solutions.

3. Increase Practice Revenue

Thread lifts are considered premium procedures, allowing practitioners to charge competitive rates while delivering exceptional results.

4. Stand Out in the Industry

By mastering advanced techniques like thread lifts, you position yourself as a leader in the aesthetics field, setting your practice apart from competitors.

5. Deliver Outstanding Client Satisfaction

Thread lifts provide natural, long-lasting results that clients appreciate, fostering trust and loyalty.

What to Expect in Thread Lift Training

Thread lift courses are meticulously designed to equip practitioners with the theoretical knowledge and hands-on skills necessary to perform this advanced procedure safely and effectively.

Core Elements of a Comprehensive Training Program:

In-Depth Theoretical Knowledge

Anatomy of the face, neck, and body to ensure precise thread placement.

Properties and types of threads, including PDO, PLA, and PCL, and their respective uses.

Mechanisms of action, focusing on tissue lifting and collagen stimulation.

Hands-On Practice

Practical training on live models to build confidence and proficiency.

Techniques for inserting barbed, smooth, and cog threads.

Customizing treatments based on individual client anatomy and aesthetic goals.

Safety Protocols and Risk Management

Proper client screening to identify contraindications.

Techniques to minimize complications such as bruising, swelling, or thread migration.

Protocols for managing adverse events and ensuring client safety.

Consultation and Aftercare

Educating clients on the benefits, risks, and expected outcomes of thread lifts.

Setting realistic expectations to ensure client satisfaction.

Post-procedure care instructions to optimize results.

Advanced Techniques

Specialized training in non-surgical nose lifting.

Full-face rejuvenation and combination treatments.

Body contouring applications, such as lifting sagging skin on the arms or abdomen.

Who Can Enroll in Thread Lift Training?

Thread lift training is open to licensed medical professionals, including:

Physicians (MDs, DOs)

Dentists

Nurse practitioners (NPs)

Registered nurses (RNs)

Physician assistants (PAs)

Before enrolling, ensure you meet the legal requirements to perform thread lifts in your region.

Choosing the Right Training Program

To ensure a successful learning experience, select a thread lift training program that offers:

Accreditation: Courses accredited by reputable organizations in the medical aesthetics industry.

Experienced Trainers: Instructors with extensive expertise in thread lift procedures.

Live Model Practice: Hands-on training to build real-world confidence and skills.

Comprehensive Curriculum: Coverage of both foundational theory and advanced techniques.

Post-Training Support: Access to mentorship and advanced workshops for continuous growth.

Integrating Thread Lifts Into Your Practice

Once you’ve completed your training, incorporating thread lifts into your services involves strategic steps:

1. Educate Your Clients

Use consultations to explain the benefits and results of thread lifts.

Share before-and-after photos to build trust and set realistic expectations.

2. Combine Treatments

Pair thread lifts with Botox, dermal fillers, or PRP for enhanced anti-aging effects.

3. Market Effectively

Promote thread lifts through social media, email campaigns, and in-office materials. Highlight their minimally invasive nature and long-term benefits.

4. Invest in Quality Supplies

Use high-quality threads from trusted manufacturers to ensure optimal client satisfaction.

5. Stay Updated

Attend advanced courses and workshops to refine your skills and stay informed about industry advancements.

The Future of Thread Lifts

As technology continues to evolve, thread lifts are becoming even more effective and versatile. Innovations in thread materials and designs, as well as the integration of combination treatments, are expanding the possibilities for non-surgical rejuvenation.

For medical practitioners, staying ahead of these advancements is crucial to maintaining a competitive edge and delivering exceptional

Thread lifts represent the perfect intersection of science and artistry in medical aesthetics. For clients, they offer a safe, effective solution to combat the signs of aging. For practitioners, mastering this technique is a strategic investment that enhances expertise, boosts revenue, and solidifies their reputation in the industry.

By enrolling in a high-quality thread lift training program and continuously refining your skills, you can confidently offer this innovative procedure and elevate your aesthetic practice to new heights.

[itskaneinstitute]

Thread Lifts: The Art of Non-Surgical Skin Rejuvenation

The pursuit of youthful, radiant skin has never been more accessible, thanks to advances in non-surgical cosmetic treatments like thread lifts. This minimally invasive procedure offers an effective solution to sagging skin, restoring firmness and enhancing facial contours without the risks or downtime associated with surgery.

This article delves into the world of thread lifts, exploring their benefits, procedure, and why they are transforming the landscape of medical aesthetics.

What Is a Thread Lift?

A thread lift is a cutting-edge cosmetic treatment designed to lift and tighten loose skin using biodegradable threads placed under the skin’s surface. The threads provide immediate lifting effects and stimulate the natural production of collagen, resulting in long-lasting rejuvenation.

Common areas treated with thread lifts include:

Cheeks and midface

Jawline and jowls

Neck and décolletage

Eyebrows and forehead

Thread lifts have gained popularity for their ability to deliver noticeable results with minimal disruption to daily life.

Types of Threads Used

The threads used in a thread lift procedure vary based on material and function:

1. Polydioxanone (PDO)

Commonly used, PDO threads dissolve naturally within 6–12 months and stimulate collagen production.

2. Polylactic Acid (PLA)

PLA threads are known for their longer-lasting collagen-stimulating properties, with effects extending up to two years.

3. Polycaprolactone (PCL)

PCL threads dissolve more slowly, offering extended benefits and stronger skin support.

Each thread type is tailored to specific needs, allowing practitioners to customize treatments for optimal outcomes.

Benefits of a Thread Lift

Thread lifts are increasingly preferred for their unique advantages over traditional facelifts:

1. Non-Surgical and Minimally Invasive

No incisions, stitches, or general anesthesia are required, reducing risks and recovery time.

2. Quick and Convenient

The procedure typically takes under an hour, with most patients resuming normal activities the same day.

3. Natural-Looking Results

The subtle lift achieved enhances natural beauty without creating an overly tight or artificial appearance.

4. Stimulates Collagen Production

By promoting the skin’s natural healing response, thread lifts improve skin texture, tone, and elasticity.

5. Versatility

Thread lifts can be customized to address various facial and neck concerns, either alone or in combination with other treatments.

The Thread Lift Procedure

A thread lift is a straightforward procedure performed in a clinical setting:

1. Consultation

During the initial consultation, the practitioner assesses the client’s facial anatomy, discusses aesthetic goals, and determines the appropriate treatment plan.

2. Preparation

The treatment area is cleansed, and a local anesthetic is applied to ensure comfort.

3. Thread Placement

Using a fine needle or cannula, threads are inserted under the skin and positioned to lift sagging tissue.

4. Completion

Excess thread is trimmed, and the practitioner ensures symmetry and balance.

The entire process is efficient, with immediate visible improvements.

Recovery and Aftercare

Thread lifts require minimal recovery time, with patients often returning to normal activities within a day or two.

Post-Procedure Guidelines:

Avoid heavy facial movements and strenuous activities for at least two weeks.

Sleep with your head elevated to minimize swelling.

Refrain from massaging or pressing on the treated areas.

Temporary side effects like mild swelling, bruising, or soreness typically subside within a week.

Results and Longevity

The results of a thread lift are both immediate and progressive. The lifting effect is visible right after the procedure, while collagen stimulation enhances skin quality over the following months.

How Long Do Results Last?

PDO threads: 12–18 months

PLA threads: Up to 2 years

PCL threads: Up to 2–3 years

Periodic touch-ups can help maintain the rejuvenated appearance.

Who Is an Ideal Candidate for a Thread Lift?

Thread lifts are ideal for individuals seeking a subtle, natural enhancement without undergoing surgery. They are best suited for those experiencing mild to moderate skin laxity.

However, individuals with severe sagging or significant aging signs may benefit more from a surgical facelift. A consultation with a qualified aesthetic professional can determine the most appropriate approach.

Why Are Thread Lifts Popular?

The popularity of thread lifts stems from their ability to deliver impressive results with minimal invasiveness. Patients appreciate the natural enhancement, while practitioners value the opportunity to offer a cutting-edge solution that aligns with modern preferences for non-surgical treatments.

Moreover, thread lifts can be combined with other aesthetic procedures like Botox, dermal fillers, or PRP therapy for comprehensive facial rejuvenation.

Training and Certification in Thread Lifts

For medical professionals, thread lift training is an invaluable addition to their skillset. Comprehensive courses cover:

Anatomy and thread placement techniques

Safety protocols and complication management

Hands-on practice under expert supervision

Combining thread lifts with other aesthetic treatments

By mastering thread lifts, practitioners can expand their services, attract more clients, and stay competitive in the aesthetics industry.

Thread lifts are revolutionizing the world of facial rejuvenation by providing a minimally invasive, effective, and affordable alternative to surgery. With immediate results, long-term benefits, and minimal downtime, they cater to the modern demand for natural and convenient cosmetic solutions.

Whether you’re an aesthetic professional looking to advance your expertise or an individual seeking a youthful glow, thread lifts represent a transformative approach to beauty and confidence.

[wildflowerbaltimore]

Ian Swanson

Her Glorious Self was meant for Elsewhere

2023

15 x 14 x 8"

Polycaprolactone, beach glass, stone, synthetic hair, XPS foam

[sunaleisocial]

Implantable microparticles can deliver two cancer therapies at once

New Post has been published on https://sunalei.org/news/implantable-microparticles-can-deliver-two-cancer-therapies-at-once/

Implantable microparticles can deliver two cancer therapies at once

Patients with late-stage cancer often have to endure multiple rounds of different types of treatment, which can cause unwanted side effects and may not always help.

In hopes of expanding the treatment options for those patients, MIT researchers have designed tiny particles that can be implanted at a tumor site, where they deliver two types of therapy: heat and chemotherapy.

This approach could avoid the side effects that often occur when chemotherapy is given intravenously, and the synergistic effect of the two therapies may extend the patient’s lifespan longer than giving one treatment at a time. In a study of mice, the researchers showed that this therapy completely eliminated tumors in most of the animals and significantly prolonged their survival.

“One of the examples where this particular technology could be useful is trying to control the growth of really fast-growing tumors,” says Ana Jaklenec, a principal investigator at MIT’s Koch Institute for Integrative Cancer Research. “The goal would be to gain some control over these tumors for patients that don’t really have a lot of options, and this could either prolong their life or at least allow them to have a better quality of life during this period.”

Jaklenec is one of the senior authors of the new study, along with Angela Belcher, the James Mason Crafts Professor of Biological Engineering and Materials Science and Engineering and a member of the Koch Institute, and Robert Langer, an MIT Institute Professor and member of the Koch Institute. Maria Kanelli, a former MIT postdoc, is the lead author of the paper, which appears today in the journal ACS Nano.

Dual therapy

Patients with advanced tumors usually undergo a combination of treatments, including chemotherapy, surgery, and radiation. Phototherapy is a newer treatment that involves implanting or injecting particles that are heated with an external laser, raising their temperature enough to kill nearby tumor cells without damaging other tissue.

Current approaches to phototherapy in clinical trials make use of gold nanoparticles, which emit heat when exposed to near-infrared light.

The MIT team wanted to come up with a way to deliver phototherapy and chemotherapy together, which they thought could make the treatment process easier on the patient and might also have synergistic effects. They decided to use an inorganic material called molybdenum sulfide as the phototherapeutic agent. This material converts laser light to heat very efficiently, which means that low-powered lasers can be used.

To create a microparticle that could deliver both of these treatments, the researchers combined molybdenum disulfide nanosheets with either doxorubicin, a hydrophilic drug, or violacein, a hydrophobic drug. To make the particles, molybdenum disulfide and the chemotherapeutic are mixed with a polymer called polycaprolactone and then dried into a film that can be pressed into microparticles of different shapes and sizes.

For this study, the researchers created cubic particles with a width of 200 micrometers. Once injected into a tumor site, the particles remain there throughout the treatment. During each treatment cycle, an external near-infrared laser is used to heat up the particles. This laser can penetrate to a depth of a few millimeters to centimeters, with a local effect on the tissue.

“The advantage of this platform is that it can act on demand in a pulsatile manner,” Kanelli says. “You administer it once through an intratumoral injection, and then using an external laser source you can activate the platform, release the drug, and at the same time achieve thermal ablation of the tumor cells.”

To optimize the treatment protocol, the researchers used machine-learning algorithms to figure out the laser power, irradiation time, and concentration of the phototherapeutic agent that would lead to the best outcomes.

That led them to design a laser treatment cycle that lasts for about three minutes. During that time, the particles are heated to about 50 degrees Celsius, which is hot enough to kill tumor cells. Also at this temperature, the polymer matrix within the particles begins to melt, releasing some of the chemotherapy drug contained within the matrix.

“This machine-learning-optimized laser system really allows us to deploy low-dose, localized chemotherapy by leveraging the deep tissue penetration of near-infrared light for pulsatile, on-demand photothermal therapy. This synergistic effect results in low systemic toxicity compared to conventional chemotherapy regimens,” says Neelkanth Bardhan, a Break Through Cancer research scientist in the Belcher Lab, and second author of the paper.

Eliminating tumors

The researchers tested the microparticle treatment in mice that were injected with an aggressive type of cancer cells from triple-negative breast tumors. Once tumors formed, the researchers implanted about 25 microparticles per tumor, and then performed the laser treatment three times, with three days in between each treatment.

“This is a powerful demonstration of the usefulness of near-infrared-responsive material systems,” says Belcher, who, along with Bardhan, has previously worked on near-infrared imaging systems for diagnostic and treatment applications in ovarian cancer. “Controlling the drug release at timed intervals with light, after just one dose of particle injection, is a game changer for less painful treatment options and can lead to better patient compliance.”

In mice that received this treatment, the tumors were completely eradicated, and the mice lived much longer than those that were given either chemotherapy or phototherapy alone, or no treatment. Mice that underwent all three treatment cycles also fared much better than those that received just one laser treatment.

The polymer used to make the particles is biocompatible and has already been FDA-approved for medical devices. The researchers now hope to test the particles in larger animal models, with the goal of eventually evaluating them in clinical trials. They expect that this treatment could be useful for any type of solid tumor, including metastatic tumors.

The research was funded by the Bodossaki Foundation, the Onassis Foundation, a Mazumdar-Shaw International Oncology Fellowship, a National Cancer Institute Fellowship, and the Koch Institute Support (core) Grant from the National Cancer Institute.

[jcmarchi]

Implantable microparticles can deliver two cancer therapies at once

New Post has been published on https://thedigitalinsider.com/implantable-microparticles-can-deliver-two-cancer-therapies-at-once/

Implantable microparticles can deliver two cancer therapies at once

Patients with late-stage cancer often have to endure multiple rounds of different types of treatment, which can cause unwanted side effects and may not always help.

In hopes of expanding the treatment options for those patients, MIT researchers have designed tiny particles that can be implanted at a tumor site, where they deliver two types of therapy: heat and chemotherapy.

This approach could avoid the side effects that often occur when chemotherapy is given intravenously, and the synergistic effect of the two therapies may extend the patient’s lifespan longer than giving one treatment at a time. In a study of mice, the researchers showed that this therapy completely eliminated tumors in most of the animals and significantly prolonged their survival.

“One of the examples where this particular technology could be useful is trying to control the growth of really fast-growing tumors,” says Ana Jaklenec, a principal investigator at MIT’s Koch Institute for Integrative Cancer Research. “The goal would be to gain some control over these tumors for patients that don’t really have a lot of options, and this could either prolong their life or at least allow them to have a better quality of life during this period.”

Jaklenec is one of the senior authors of the new study, along with Angela Belcher, the James Mason Crafts Professor of Biological Engineering and Materials Science and Engineering and a member of the Koch Institute, and Robert Langer, an MIT Institute Professor and member of the Koch Institute. Maria Kanelli, a former MIT postdoc, is the lead author of the paper, which appears today in the journal ACS Nano.

Dual therapy

Patients with advanced tumors usually undergo a combination of treatments, including chemotherapy, surgery, and radiation. Phototherapy is a newer treatment that involves implanting or injecting particles that are heated with an external laser, raising their temperature enough to kill nearby tumor cells without damaging other tissue.

Current approaches to phototherapy in clinical trials make use of gold nanoparticles, which emit heat when exposed to near-infrared light.

The MIT team wanted to come up with a way to deliver phototherapy and chemotherapy together, which they thought could make the treatment process easier on the patient and might also have synergistic effects. They decided to use an inorganic material called molybdenum sulfide as the phototherapeutic agent. This material converts laser light to heat very efficiently, which means that low-powered lasers can be used.

To create a microparticle that could deliver both of these treatments, the researchers combined molybdenum disulfide nanosheets with either doxorubicin, a hydrophilic drug, or violacein, a hydrophobic drug. To make the particles, molybdenum disulfide and the chemotherapeutic are mixed with a polymer called polycaprolactone and then dried into a film that can be pressed into microparticles of different shapes and sizes.

For this study, the researchers created cubic particles with a width of 200 micrometers. Once injected into a tumor site, the particles remain there throughout the treatment. During each treatment cycle, an external near-infrared laser is used to heat up the particles. This laser can penetrate to a depth of a few millimeters to centimeters, with a local effect on the tissue.

“The advantage of this platform is that it can act on demand in a pulsatile manner,” Kanelli says. “You administer it once through an intratumoral injection, and then using an external laser source you can activate the platform, release the drug, and at the same time achieve thermal ablation of the tumor cells.”

To optimize the treatment protocol, the researchers used machine-learning algorithms to figure out the laser power, irradiation time, and concentration of the phototherapeutic agent that would lead to the best outcomes.

That led them to design a laser treatment cycle that lasts for about three minutes. During that time, the particles are heated to about 50 degrees Celsius, which is hot enough to kill tumor cells. Also at this temperature, the polymer matrix within the particles begins to melt, releasing some of the chemotherapy drug contained within the matrix.

“This machine-learning-optimized laser system really allows us to deploy low-dose, localized chemotherapy by leveraging the deep tissue penetration of near-infrared light for pulsatile, on-demand photothermal therapy. This synergistic effect results in low systemic toxicity compared to conventional chemotherapy regimens,” says Neelkanth Bardhan, a Break Through Cancer research scientist in the Belcher Lab, and second author of the paper.

Eliminating tumors

The researchers tested the microparticle treatment in mice that were injected with an aggressive type of cancer cells from triple-negative breast tumors. Once tumors formed, the researchers implanted about 25 microparticles per tumor, and then performed the laser treatment three times, with three days in between each treatment.

“This is a powerful demonstration of the usefulness of near-infrared-responsive material systems,” says Belcher, who, along with Bardhan, has previously worked on near-infrared imaging systems for diagnostic and treatment applications in ovarian cancer. “Controlling the drug release at timed intervals with light, after just one dose of particle injection, is a game changer for less painful treatment options and can lead to better patient compliance.”

In mice that received this treatment, the tumors were completely eradicated, and the mice lived much longer than those that were given either chemotherapy or phototherapy alone, or no treatment. Mice that underwent all three treatment cycles also fared much better than those that received just one laser treatment.

The polymer used to make the particles is biocompatible and has already been FDA-approved for medical devices. The researchers now hope to test the particles in larger animal models, with the goal of eventually evaluating them in clinical trials. They expect that this treatment could be useful for any type of solid tumor, including metastatic tumors.

The research was funded by the Bodossaki Foundation, the Onassis Foundation, a Mazumdar-Shaw International Oncology Fellowship, a National Cancer Institute Fellowship, and the Koch Institute Support (core) Grant from the National Cancer Institute.

[materialsscienceandengineering]

Embedding aligned nanofibrous architectures within 3D-printed polycaprolactone scaffolds for tissue regeneration

The existing 3D-printed scaffolds commonly possess a thick feature size of hundreds of micrometers, which is too large for most cells (10–20 μm) to attach and proliferate for promoting tissue regeneration. Researchers from Xi'an Jiaotong University have developed a novel hybrid manufacturing technique for the fabrication of composite scaffolds with 3D-printed macroscale frameworks and aligned nanofibrous architectures to improve cellular organizations.

Publishing in the journal International Journal of Extreme Manufacturing, the team led by researchers based at State Key Laboratory for Manufacturing Systems Engineering combined the techniques of 3D printing, electrospinning, unidirectional freeze-casting, and lyophilization to embed ECM-biomimetic fibrillar architectures inside previously 3D-printed scaffolds.

Compared with 3D-printed scaffolds, the developed composite scaffolds with hierarchical structures were able to improve the seeding efficiency, proliferation rate, and morphogenesis of the seeded cells, and guide the directional cellular ingrowth. The findings could have a widespread impact on the development of composite scaffolds with hierarchical architectures potentially for the orderly spatial regeneration and remodeling of tissues in the future.

Read more.

[aesthisave]

Gouri Skin Booster: The New Era of Skin Rejuvenation Will Revitalize Your Skin

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