#photoredox catalysis

[hood32]

For Quarantine reading: here’s my first First-Author JACS article! Look how pretty those spirocycles are... and peek at the NMRs of them in the SI! Best project ever and best team ever, my fiancé is even an author on it with me! 🥰

https://pubs.acs.org/doi/10.1021/jacs.0c03926

[materialsscienceandengineering]

New light-powered catalysts could aid in manufacturing

Chemical reactions that are driven by light offer a powerful tool for chemists who are designing new ways to manufacture pharmaceuticals and other useful compounds. Harnessing this light energy requires photoredox catalysts, which can absorb light and transfer the energy to a chemical reaction.

MIT chemists have now designed a new type of photoredox catalyst that could make it easier to incorporate light-driven reactions into manufacturing processes. Unlike most existing photoredox catalysts, the new class of materials is insoluble, so it can be used over and over again. Such catalysts could be used to coat tubing and perform chemical transformations on reactants as they flow through the tube.

"Being able to recycle the catalyst is one of the biggest challenges to overcome in terms of being able to use photoredox catalysis in manufacturing. We hope that by being able to do flow chemistry with an immobilized catalyst, we can provide a new way to do photoredox catalysis on larger scales," says Richard Liu, an MIT postdoc and the joint lead author of the new study.

Read more.

[gastonthethird]

TEXT ✉️ GASTINE

Claudine: Hey, I don’t know if you want to join but I’m trying something out for science club and I thought you’d find this fun. It’s deoxygenation using visible light photoredox catalysis.

Gaston: Aww, come on Claudine, you know I don't have the time or "the brain" to join science club. I've gotta focus on football and frat stuff, and I'm not that into it.

Gaston: ...is that the kind of reaction you could catch on video, though? Or would it not turn out?

[jobrxiv]

Postdoctoral researcher in the field of photo- end electrochemical C(sp3)-H functionalization Institute of Organic Chemistry, Polish Academy of Sciences Application Deadline: 2022-08-31 We are looking for a motivated and creative Candidate holding a PhD degree in Organic Synthesis and ready to work as a postdoctoral scholar in our ongoing research project devoted to the remote C(sp3)-H functionalization of bifunctional compounds finansed by the Polish National Science Center. The project is realized by The Stecko Research Group at the Institute of Organic Chemistry of the Polish Academy of Sciences (IOC PAS) in Warsaw (Poland).  Job description: The focus of the project is developing novel methods for self- and a directing group aided C(sp3)-H functionalization of simple bi- and polyfunctional organic molecules. Most of the efforts will be put on the development mild and versatile protocols under modern radical photoredox or electrochemical conditions. The post-doctorate scholar (PDS) will be responsible for synthesizing, depositing, and characterizing of the starting materials and intermediates, followed by an optimization of reaction conditions for model transforma... See the full job description on jobRxiv: https://jobrxiv.org/job/institute-of-organic-chemistry-polish-academy-of-sciences-27778-postdoctoral-researcher-in-the-field-of-photo-end-electrochemical-csp3-h-functionalization/?feed_id=20595 #ScienceJobs #hiring #research #catalysis #photocatalysis #electrocatalysis #postdoc #organicchemistry #PostDocPosition #chemjobs #ChemPostDoc #SyntheticChemistry

[trilionstudios]

Work we did for Kansas University’s chemistry Lab - Bloom Lab Group. Here’s the branding and some of the photos and videos we shot in the lab. The mark deals with “photoredox catalysis��� basically using specials lights to create medicinally relevant compounds. On the 5th slide you can see the chemical reaction with special lights. . . . #brand #branding #logo #logos #logodesign #logodesigner #logodesigns #logomaker #logotype #logobrand #logoprocess #logodaily #logologo #logoawesome #branddesigner https://www.instagram.com/p/CYZcNpPFmkp/?utm_medium=tumblr

[brianwhitedesign]

Finally able to show off the work I did for Kansas University’s chemistry Lab - Bloom Lab Group. Here’s the branding and some of the photos and videos I shot in the lab. The mark deals with “photoredox catalysis” basically using specials lights to create medicinally relevant compounds. On the 5th slide you can see the chemical reaction with special lights. . . . #brand #branding #logo #logos #logodesign #logodesigner #logodesigns #logomaker #logotype #logobrand #logoprocess #logodaily #logologo #logoawesome #branddesigner https://www.instagram.com/brianwhitedesign/p/CYZcDdmFp_k/?utm_medium=tumblr

[tatvachintan]

Quaternary Ammonium Salts As A Chiral Catalysts

Are you aware of Quaternary ammonium salts? What do you think of that? Is this a Specialty Chemical? It has developed as potential chiral catalysts for challenging responses that are not likely with other techniques. This article will focus some of the most outstanding current examples in this ground. And demonstrate the capability of these catalysts to simplify abstract makeovers in a vastly stereoselective manner under slight reaction circumstances.

Chiral Quaternary ammonium salt catalysts have appeared as one of the exceptional catalytic values over the last years. As declared by Chemical Manufacturer, their capability to stimulate nucleophiles in a noncovalent style makes them exclusive. Nevertheless, over the last decades, it has become clear that in a diversity of demanding renovations start. As well as a regulator of nucleophiles only does not affect adequate selectivity. The same holds factual for the solitary regulator of electrophiles by other catalytic ideas. Bifunctional chiral urea-comprising quaternary ammonium salts can be candidly produced in a good crop.

And with high basic assortment through an accessible and functionally simple vastly contracted structure beginning from trans-1,2-cyclohexanediamine. These original cross catalysts were analytically examined for their possibility to regulate glycine Schiff bases in unequal addition responses. It was established that addition feedbacks and the herein offered aldol-introduced torrent feedback can be continued to give enantiomeric proportions up to 95.5 and good produce under moderate conditions at room temperature.

Exceptional organo-catalysis of both arising cinchona alkaloid-consequent and only artificial chiral quaternary ammonium fluorides in unnaturally handy stereoselective bond-founding responses is outlined. The progress of this interaction was commenced by the in situ group of commonly hygroscopic ammonium fluorides from the conforming easy-to-manage ammonium salts in the manifestation of excess metal fluorides. And their undeviating use for following enantioselective feedbacks.

Instead, chiral ammonium fluorides have been ready by using ion-exchange mastics. As well as effectively functions as a catalyst to several asymmetric bond creation feedbacks under standardized settings. Furthermore, consumption of chiral quaternary ammonium bifluorides as organocatalysts in the irregular mixture is designated, presenting their distinguishing awareness and discernment.

The most distinctive chiral quaternary ammonium salts for unbalanced catalysis are originated from the chincona alkaloid classification of regular merchandises through simple N-alkylation. Let’s talk about some information concerning this topic. Pollutant from catalyst disintegration was supposed to pollute products, giving mistaken gyration standards.

Because of the trial of sustainability confronting our culture in the approaching years. Catalysis is without any hesitation a study area of vast significance. By the way, unequal organo-catalysis, currently deliberated a leader of green chemistry, justifies special consideration.

This is to observe the uneven organocatalysis in light of fundamental chemistry. A current significant development in this ground has been reached by upholding the foundation. And connecting the high awareness of open-shell transitional. Integrating organocatalysis with essential chemistry has been the basic to deciphering several enduring blockages. It has also expressively subsidized to strengthening the major task of organocatalysis in unequal catalysis. This article shows the most important progress to this extent, with a specific emphasis on distorted SOMO- and photoredox-organocatalyzed revolutions.

Stresses on quaternary, specifically chiral byproducts, and their conduct as exclusive catalysts in organocatalysis. Creating chiral ion-pairs accomplished of endorsing irregular feedbacks. They also work as exclusive “carriers” contained in phase transmission catalytic procedures among liquid–liquid or liquid–solid schemes.

Furthermore, they propose distinctive chances once creating helpful ion-paired objects enabling a synergistic repercussion of the counter-ion X- either as Bronsted bases or Lewis bases. The particular strategy of such chiral catalysts in modern chemistry and better vision into their manner of start simplifies resourceful and unparalleled chemical revolutions. This article offers an impression of the use of chiral quaternary ammonium salts in organocatalysis. To highlighting both overall automatic features and the range of this method.

[clarencegamboa-blog]

via Twitter https://twitter.com/oneclipsesci

[chakabin]

I thought you might be interested in the following content published on the ACS Web Editions Platform:

Predictive Model for Site-Selective Aryl and Heteroaryl C–H Functionalization via Organic Photoredox Catalysis Kaila A. Margrey, Joshua B. McManus, Simone Bonazzi, Frederic Zecri and David A. Nicewicz J. Am. Chem. Soc., Article ASAP DOI: 10.1021/jacs.7b06715 Publication Date (Web): 8 08, 2017 Copyright © 2017, American Chemical Society

[hood32]

Photoredox catalysis is a large part of what we investigate in our lab (Jui Group, Emory University). Whether our chemistry utilizes iridium centered photocatalysts or organic dyes (pictured here: fluorescein and rhodamine), the reactions are always stunning since they are irradiated by a blue light. The reactions are held in a custom reaction tube holder designed and 3D printed by Dave. 

[materialsscienceandengineering]

Method to apply microfluidic electrochemical technologies to single-electron transfer redox-neutral reactions

A team of chemists and engineers at MIT has found a new way to apply microfluidic electrochemical technologies to single-electron transfer (SET) redox-neutral reactions. In their paper published in the journal Science, the group describes introducing a microfluidic redox-neutral electrochemistry to the platform and explain why they believe it has broad applicability to SET chemistry. Jian-Quan Liu, Andrey Shatskiy and Markus Kärkäs have published a Perspective piece in the same journal issue outlining the recent history of photoredox catalysis and electrosynthesis, and explaining why it is an important component of the search for new synthetic methods—they also outline the work by the team at MIT.

Over the past several years, chemists have been looking into new ways to use visible-light photocatalysis as part of organic synthesis efforts. And while such efforts have proved fruitful in a variety of ways, they have also run into serious limitations—the need for retuning of redox potentials, for example, and the high expense involved when using transition-metal photocatalysts. There have also been incompatibility issues and the need to remove transition metals. Such issues have led chemists to turn to electrosynthesis, which, as its name implies, is a type of synthesis that is aided by electricity. The researchers note that in many ways, electrosynthesis is an excellent choice for use in radical coupling; in principle, it is both simpler and cheaper—a given precursor is oxidized near the anode, while its counterpart is reduced near the cathode. The big problem has been one or the other partners losing stability before they meet somewhere in the center.

Read more.

[kangaske]

Light emitting quantum dots could ease synthesis of novel compounds

At one time you could wander through the labs of pharmaceutical companies and hardly ever see light being used to mediate chemical reactions. Now "photoredox catalysis" has become an essential way to synthesize novel organic compounds. http://dlvr.it/PGSWvH

[davidrussellschilling]

Polymer Synthesis

C O N T E N T S:

GENERAL INFO

KEY TOPICS

This review, with over 600 references, summarizes the recent applications of photoredox catalysis for organic transformation and polymer synthesis.(More…)

POSSIBLY USEFUL

Now, it has been shown that such polymers based on nickelocene are dynamic due to weaker nickel-cyclopentadienyl interactions, and at low concentration or at elevated temperature,…

[hood32]

Gradblr Challenge

I saw this Gradblr Challenge today, and thought it’d be a great thing to participate in! I just had a chat with my advisor this week and I was asking him what I should do to make sure I have an unreasonably productive PhD, and so I have some ideas on how to implement things we talked about during this challenge! :) 

name or nickname: Autumn

location: Emory University, Atlanta GA

area of study: Chemistry (Synthetic Organic/Catalytic/Photoredox)

level of study: PhD, I’m a candidate in my 3rd year! 

a word on your thesis/dissertation: Currently I’m working on designing and synthesizing modulators (right now mostly agonists, maybe later antagonists) for the mammalian nuclear receptor LRH-1. It sounds very biology-y but I’m truly truly a synthetic chemist. No biology work for me at all, that’s what collaborations are for! After the next three papers on these modulators (yes, three lined up, none published yet...such is the life of interdisciplinary collaborations) I’ll start a new project in catalysis to broaden the scope of  my PhD, hopefully that’ll start before Christmas. 

what you hope to accomplish with this challenge: In short, I want to (as our PI says) “be better.” I’ll be focusing on reading more journal articles (and summarizing them for you guys!) and making each and every reaction I do count, gathering the crucial characterization data along the way (I’m bad at this, I always think it’s no big deal to go back and remake something). 

is this your first #gradblrchallenge: yes! I didn’t know they existed!

favourite film: I can watch Moulin Rouge over and over and over and never get tired of it. 

favourite tv series: Just finished watching Jane the Virgin, shamelessly love that series. Maybe not my favorite ever but I can’t think of anything else right now. 

*places you wish to visit in a near future: Visiting the Western Carribean with my S.O. this September, always loved the idea of tropical-type islands but never got far on those plans. I’d love to visit Montana again! And my hometown in the northern Midwest, missing the hell out of my family <3 

*meaning behind your url: During my two years of research in undergrad, I worked in Hood # 32... AND during my two years of REUs in undergrad my hood # was also #32! It was too much of a coincidence :) 

*when you are not working on your studies, you are…: BY THE POOL. Watching Game of Thrones on Sundays, watching West World on Sundays when it’s WW season, watching Netflix, playing Zelda on the Switch I got for my birthday, on the phone with my best friends or family, playing with our new cat Penelope (Penny!). Planning vacations I’ll never be able to take, online shopping and then closing the tab because I’m a grad student and can’t afford anything... Trivia on Thursday nights, and hiking and camping when the weather isn’t too hot :) 

*a random fact about you: I’ve always vainly considered myself smarter/better at chemistry than the average student (the only kind of people that go into PhD programs in chemistry tbh), but that basically changed when I started dating (and recently: living with!) a coworker in my lab. He’s so incredibly fucking smart and is a huge inspiration to continue to learn about the bigger world of chemistry and tech.