#noninvasive technique

[afeelgoodblog]

The Best News of Last Week - October 30, 2023

1. Bill to Ban Hidden Fees in California Signed into Law

California Attorney General Rob Bonta has released a statement regarding the signing of Senate Bill 478 (SB 478). SB 478, coauthored by Senators Bill Dodd and Nancy Skinner, will eliminate hidden fees, also known as 'junk fees,' in California starting from July 1, 2024. Hidden fees are deceptive charges that sellers include in transactions, either through obscured disclosures or later revelations, impacting consumers negatively.

2. New Portable Water Treatment System Vaporizes 99% of ‘Forever Chemicals’

A startup based Washington has devised a portable system capable of removing the vast majority of per- and polyfluoroalkyl substances, or PFAS, from water.

The system uses hydrothermal alkaline treatment, or HALT, to eliminate 99% of forever chemicals from water.

3. Tumor-destroying sound waves receive FDA approval for liver treatment in humans

The U.S. Food and Drug Administration has approved the use of sound waves to break down tumors—a technique called histotripsy—in humans for liver treatment. Technique developed at the University of Michigan provides a noninvasive alternative to surgery, chemotherapy and radiation treatments for cancer

4. Japan's top court says trans sterilisation requirement unconstitutional

Japan's Supreme Court has ruled that it is unconstitutional to require citizens to be sterilised before they can officially change genders.

The 2004 law said people could only change their gender if they have no reproductive capacity. Wednesday's ruling came after a transgender woman filed a petition challenging the law.

5. Abandoned golf courses are being reclaimed by nature

Golf courses, despite occupying large green spaces, are not necessarily good for the environment.

Conservation nonprofits and local authorities are looking to acquire golf courses that have been abandoned due to high maintenance costs, low player numbers or other reasons, and repurpose them into landscapes that boost biodiversity and build natural defenses against climate change.

6. NSW court allows health officials to give blood transfusion to Jehovah's Witness toddler

Regional New South Wales health officials have won a court order authorising them to give a blood transfusion to a Jehovah's Witness toddler if needed in surgery. The Supreme Court has been told the girl, three, who can only be referred to as JI, is in need of two surgical procedures. 

On such an application, the overriding criterion to be applied by the court is the best interests and welfare of the child.

7. North Atlantic right whale population has steadied, scientists say

The population of critically endangered North Atlantic right whales appears to have levelled off after a decade of steep decline, according to updated data released this morning by Canadian and American scientists. Scientists in the consortium said Monday that the 2021 estimate of 340 North Atlantic right whales in existence has been recalculated to 365 primarily because of the number of calves born that year.

The estimate for 2022 is 356.

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[mirkokosmos]

Scientists use Matrix-style learning to ‘write’ skills into human brain noninvasively. This technique uses real-time brain imaging and neurofeedback. It bypasses learning processes that require effort, study, or practice.

[cbirt]

Understanding cell dynamics, regulation, and characteristics has been revolutionized by profiling tests at a previously unheard-of resolution. Nevertheless, the destructive nature of these techniques makes it difficult to monitor the temporal dynamics of living cells. Although it lacks genetic and molecular interpretability, Raman microscopy offers a unique way to report vibrational energy levels at subcellular spatial resolution. The researchers created Raman2RNA (R2R), an experimental and computational framework that uses multi-modal data integration, domain translation, and label-free hyperspectral Raman microscopy images to infer single-cell expression patterns in living cells. 

Raman images were used to link scRNA-seq profiles to paired spatial hyperspectral Raman images, and machine learning models were trained to infer expression profiles from Raman spectra at the single-cell level. In reprogramming mouse fibroblasts into induced pluripotent stem cells (iPSCs), R2R accurately inferred the expression patterns of numerous cell stages and fates, including MET cells, iPSCs, stromal cells, fibroblasts, and epithelial cells. This demonstrates how crucial spectroscopic content is to Raman microscopy.

The dynamic balance of extrinsic and internal programs determines the states and functions of cells. Numerous genes work together to coordinate the expression and function of these activities, which include cell proliferation, stress responses, differentiation, and reprogramming. These genes also interact with other cells and the environment to influence these processes.

Continue Reading

[mezmer]

Insane to think they were nonsurgically "bloodlessly" curing severe spinal curvatures in adolescents over a century ago in Europe and now the prognosis is surgery or suffer, while specialized noninvasive treatments (that were curing spines 100 years ago) being gatekept by a select few individuals who charge thousands of dollars to give instructors certifications for this technique that insurance won't even cover. And I have to stare at people with straight spines all day long and look them in the eyes and try to make them like me because they don't because I'm in pain and I annoy them. And I have to awkwardly force a smile on myself just so everyone doesn't think I'm a flaming ball of hatred.

[covid-safer-hotties]

Vascular Pathogenesis in Acute and Long COVID: Current Insights and Therapeutic Outlook - Published Sept 30, 2024 (PDF)

Abstract Long coronavirus disease 2019 (COVID-19)—a postacute consequence of severe acute respiratory syndrome coronavirus 2 infection—manifests with a broad spectrum of relapsing and remitting or persistent symptoms as well as varied levels of organ damage, which may be asymptomatic or present as acute events such as heart attacks or strokes and recurrent infections, hinting at complex underlying pathogenic mechanisms. Central to these symptoms is vascular dysfunction rooted in thrombotic endothelialitis. We review the scientific evidence that widespread endothelial dysfunction (ED) leads to chronic symptomatology. We briefly examine the molecular pathways contributing to endothelial pathology and provide a detailed analysis of how these cellular processes underpin the clinical picture. Noninvasive diagnostic techniques, such as flow-mediated dilation and peripheral arterial tonometry, are evaluated for their utility in identifying ED. We then explore mechanistic, cellular-targeted therapeutic interventions for their potential in treating ED. Overall, we emphasize the critical role of cellular health in managing Long COVID and highlight the need for early intervention to prevent long-term vascular and cellular dysfunction.

[importantwomensbirthdays]

Paula T. Hammond

Chemical engineer Paula T. Hammond was born in 1963 in Detroit, Michigan. Hammond is known for her work on polymers and nanomaterials. She has pioneered processes for using layer-by-layer assembly to create polymer films and other materials. Her lab now uses these techniques for numerous applications, including battery technology, drug delivery, and noninvasive imaging. She is head of the Department of Chemical Engineering at the Koch Institute for Integrative Cancer Research at MIT. Hammond has won several awards and her work has been widely cited. She is a member of the National Academy of Sciences and the President's Council of Advisors on Science and Technology.

Image source: The White House

[jcmarchi]

Noninvasive Technique Reveals How Cells’ Gene Expression Changes Over Time - Technology Org

New Post has been published on https://thedigitalinsider.com/noninvasive-technique-reveals-how-cells-gene-expression-changes-over-time-technology-org/

Noninvasive Technique Reveals How Cells’ Gene Expression Changes Over Time - Technology Org

MIT researchers can now track a cell’s RNA expression to investigate long-term processes like cancer progression or embryonic development.

DNA – artistic impression. Image credit: Image by kjpargeter on Freepik

Sequencing all of the RNA in a cell can reveal a great deal of information about its function and what it is doing at a given time. However, the sequencing process destroys the cell, making it difficult to study ongoing changes in gene expression.

An alternative approach developed at MIT could enable researchers to track such changes over extended periods of time. The new method, which is based on a noninvasive imaging technique known as Raman spectroscopy, doesn’t harm cells and can be performed repeatedly.

Using this technique, the researchers showed that they could monitor embryonic stem cells as they differentiated into several other cell types over several days. This technique could enable studies of long-term cellular processes such as cancer progression or embryonic development, and one day might be used for diagnostics for cancer and other diseases.

“With Raman imaging you can measure many more time points, which may be important for studying cancer biology, developmental biology, and a number of degenerative diseases,” says Peter So, a professor of biological and mechanical engineering at MIT, director of MIT’s Laser Biomedical Research Center, and one of the authors of the paper.

Koseki Kobayashi-Kirschvink, a postdoc at MIT and the Broad Institute of Harvard and MIT, is the lead author of the study, which appears today in Nature Biotechnology. The paper’s senior authors are Tommaso Biancalani, a former Broad Institute scientist; Jian Shu, an assistant professor at Harvard Medical School and an associate member of the Broad Institute; and Aviv Regev, executive vice president at Genentech Research and Early Development, who is on leave from faculty positions at the Broad Institute and MIT’s Department of Biology.

Imaging gene expression

Raman spectroscopy is a noninvasive technique that reveals the chemical composition of tissues or cells by shining near-infrared or visible light on them. MIT’s Laser Biomedical Research Center has been working on biomedical Raman spectroscopy since 1985, and recently, So and others in the center have developed Raman spectroscopy-based techniques that could be used to diagnose breast cancer or measure blood glucose.

However, Raman spectroscopy on its own is not sensitive enough to detect signals as small as changes in the levels of individual RNA molecules. To measure RNA levels, scientists typically use a technique called single-cell RNA sequencing, which can reveal the genes that are active within different types of cells in a tissue sample.

In this project, the MIT team sought to combine the advantages of single-cell RNA sequencing and Raman spectroscopy by training a computational model to translate Raman signals into RNA expression states.

“RNA sequencing gives you extremely detailed information, but it’s destructive. Raman is noninvasive, but it doesn’t tell you anything about RNA. So, the idea of this project was to use machine learning to combine the strength of both modalities, thereby allowing you to understand the dynamics of gene expression profiles at the single cell level over time,” Kobayashi-Kirschvink says.

To generate data to train their model, the researchers treated mouse fibroblast cells, a type of skin cell, with factors that reprogram the cells to become pluripotent stem cells. During this process, cells can also transition into several other cell types, including neural and epithelial cells.

Using Raman spectroscopy, the researchers imaged the cells at 36 time points over 18 days as they differentiated. After each image was taken, the researchers analyzed each cell using single molecule fluorescence in situ hybridization (smFISH), which can be used to visualize specific RNA molecules within a cell. In this case, they looked for RNA molecules encoding nine different genes whose expression patterns vary between cell types.

This smFISH data can then act as a link between Raman imaging data and single-cell RNA sequencing data. To make that link, the researchers first trained a deep-learning model to predict the expression of those nine genes based on the Raman images obtained from those cells.

Then, they used a computational program called Tangram, previously developed at the Broad Institute, to link the smFISH gene expression patterns with entire genome profiles that they had obtained by performing single-cell RNA sequencing on the sample cells.

The researchers then combined those two computational models into one that they call Raman2RNA, which can predict individual cells’ entire genomic profiles based on Raman images of the cells.

Tracking cell differentiation

The researchers tested their Raman2RNA algorithm by tracking mouse embryonic stem cells as they differentiated into different cell types. They took Raman images of the cells four times a day for three days, and used their computational model to predict the corresponding RNA expression profiles of each cell, which they confirmed by comparing it to RNA sequencing measurements.

Using this approach, the researchers were able to observe the transitions that occurred in individual cells as they differentiated from embryonic stem cells into more mature cell types. They also showed that they could track the genomic changes that occur as mouse fibroblasts are reprogrammed into induced pluripotent stem cells, over a two-week period.

“It’s a demonstration that optical imaging gives additional information that allows you to directly track the lineage of the cells and the evolution of their transcription,” So says.

The researchers now plan to use this technique to study other types of cell populations that change over time, such as aging cells and cancerous cells. They are now working with cells grown in a lab dish, but in the future, they hope this approach could be developed as a potential diagnostic for use in patients.

“One of the biggest advantages of Raman is that it’s a label-free method. It’s a long way off, but there is potential for the human translation, which could not be done using the existing invasive techniques for measuring genomic profiles,” says Jeon Woong Kang, an MIT research scientist who is also an author of the study.

Written by Anne Trafton

Source: Massachusetts Institute of Technology

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[medicalcodingjob]

CPT code 74712 and 74713 Coding guide for MRI fetal exam

When to use CPT code 74712 and 74713 Magnetic resonance imaging (MRI) is a radiation-free, noninvasive technique that produces high quality sectional images of the inside of the body in multiple planes. MRI uses the natural magnetic properties of the hydrogen atoms in our bodies that emit radiofrequency signals when exposed to radiowaves within a strong electromagnetic field. These signals are…

[21st-century-minutiae]

Magnetic Resonance Imaging (MRI) is a type of noninvasive medical diagnostic tool for observing soft tissues inside the human body, such as the brain or the intestines. he patient might be injected with (or requested to invest) contrast fluid that will stand out in the images. After which, the patient will lie down on a thin tray and be inserted into the long type that is the machine. When not getting a brain scan, the head will usually be left out, so the patient can look up at the calming lights installed in the ceiling. MRIs are loud, and can be claustrophobic, but don't cause any main (the contrast is known to be uncomfortable at times, though).

Because the MRI works using high levels of magnetism, any metal in the human body can lead to dangerous tears and violent reactions. Patients cannot wear any jewelry or have any medical devices inside them when taking an MRI. If an MRI is not possible (because of a heart implant, for example), a different diagnostic technique might be used instead.

People in the early twenty-first century are likely to be familiar with MRIs, either from personal experience or through cultural osmosis. But it wouldn't be shocking for someone to be unaware of what the device is or what the initialism stands for.

Going over MRI prep for tomorrow and I know my body doesn’t have any metal in it but I’m now just lying here in bed like “hmmm but what if I do and I just don’t know it?”

Like, brain, I know we’ve been through a lot of medical trauma recently and we’ve had to do a lot of “worst case scenario” prepping that turned out to be necessary, but please, stfu.

[heartspecial]

Advanced Cardiac Treatments from the Best Heart Specialists

In today’s fast paced world, heart health has become a critical concern for individuals of all ages. With advancements in medical technology, cardiology has seen remarkable progress, offering hope and healing to countless patients. If you're in Indore and seeking exceptional cardiac care, finding a cardiologist is crucial to ensure optimal outcomes.

Understanding Advanced Cardiac Treatments

Modern cardiology has evolved far beyond traditional diagnostic methods and treatments. Advanced cardiac treatments include innovative procedures and state of the art technologies designed to address complex heart conditions effectively.

Non Invasive Diagnostic Tools

Early and accurate diagnosis is the cornerstone of effective cardiac care. Noninvasive diagnostic tools such as:

Echocardiography: This ultrasound based imaging provides real time visuals of heart structures and blood flow.

Stress Tests: These tests assess how your heart performs under physical exertion.

CT Angiography: A cutting edge imaging technique to evaluate blockages in coronary arteries.

Such tools are essential in diagnosing heart diseases without causing discomfort or risk to patients.

Minimally Invasive Cardiac Procedures

Minimally invasive techniques have revolutionized cardiac care by reducing recovery times and improving patient outcomes. Some of the widely used treatments include:

Angioplasty and Stenting: A life saving procedure to restore blood flow in blocked arteries.

Electrophysiological Studies (EPS): Used to diagnose and treat abnormal heart rhythms.

Transcatheter Aortic Valve Replacement (TAVR): A breakthrough in treating severe aortic stenosis without open heart surgery.

Surgical Interventions by Specialists

For patients requiring more intensive care, advanced surgical options such as bypass surgery, valve replacement, and heart transplants are available. The best cardiologist in indore are equipped with the expertise and technology to perform these procedures with precision.

Choosing the Best Cardiologist in Indore

Indore is home to some of the country’s most skilled and experienced cardiologists. Here are factors to consider when selecting a heart specialist:

Credentials and Experience: Look for specialists with advanced training and a proven track record in handling complex cases.

Facilities: Ensure the clinic or hospital is equipped with cutting edge diagnostic and treatment tools.

Patient Reviews: Testimonials from former patients can provide insights into the quality of care.

Preventive Cardiology: A Key to Heart Health

Beyond treatments, the focus on preventive cardiology is growing. Leading heart specialists emphasize lifestyle changes, regular checkups, and early interventions to mitigate risks. Regular monitoring of blood pressure, cholesterol levels, and blood sugar can go a long way in preventing serious cardiac issues.

Why Indore Stands Out for Cardiac Care

Indore has emerged as a hub for advanced medical care, combining affordability with excellence. Patients from across the region prefer the city for its world class cardiac care facilities and renowned specialists.

Your heart deserves the best care, and with the best heart specialists in Indore, you can rest assured of receiving top notch treatment. Whether you need routine monitoring or advanced procedures, Indore’s cardiologists are dedicated to providing personalized and effective care. Prioritize your heart health today and consult with a trusted expert to live a longer, healthier life.

[lockoutservice]

House Lockout Services – Regain Access with Dr. Locksmith Winnipeg

Few situations are as stressful as being locked out of your own home. Whether you've misplaced your keys, locked them inside, or experienced a lock malfunction, the feeling of helplessness can be overwhelming. Fortunately, Dr. Locksmith Winnipeg specializes in house lockout services Winnipeg, providing fast and reliable solutions to help you regain access to your property safely and efficiently.

What to Do During a House Lockout

If you find yourself locked out, it's essential to remain calm and avoid forcing the door open, as this can cause damage and lead to costly repairs. Instead, contact a trusted Winnipeg locksmith like Dr. Locksmith Winnipeg. Our team responds promptly to lockout calls and has the tools and expertise to resolve the issue without unnecessary damage.

Professional Lockout Solutions

Our house lockout service is designed to provide noninvasive solutions whenever possible. We can unlock most doors quickly and efficiently using specialized tools and techniques. If a lock is damaged or needs to be replaced, we offer lock change Winnipeg and lock rekeying services to restore security.

Upgrading Home Security After a Lockout

A lockout is an excellent opportunity to evaluate your home's security. If your locks are outdated or compromised, consider upgrading to modern systems such as high-security or smart ones. At Dr. Locksmith Winnipeg, we provide a range of options to enhance your home's protection, ensuring peace of mind for you and your family.

Why Choose Dr. Locksmith Winnipeg for Lockout Services?

With years of experience and a commitment to customer satisfaction, Dr. Locksmith Winnipeg has become a trusted name for home lockout service and other locksmith solutions. Our technicians are licensed, insured, and trained to handle emergencies with professionalism and care. Trust us to provide fast, affordable, and practical solutions when locked out.

[industrynewsupdates]

Respiratory Disease Testing Market Outlook, Competitive Strategies And Forecast

The global respiratory disease testing market size is expected to reach USD 7.75 billion by 2030, registering a CAGR of 2.8% from 2023 to 2030, according to a new report by Grand View Research, Inc. The market is driven by the rising prevalence of respiratory diseases. As per Forum of International Respiratory Societies, more than 200 million people across the globe suffered from Chronic Obstructive Pulmonary Disease (COPD) and 235 million suffered from asthma in 2014. In addition, the source stated that more than 50 million people struggle with occupational lung diseases annually. Thus, constantly growing target patient population is anticipated to drive the growth.

The adoption of innovative technologies, such as Computed Tomography (CT), for COPD diagnosis is expected to drive the growth. The other new technology in acute medical management of COPD is pulse oximeter that is used for outpatient monitoring.  Airway management plays a main role in testing and management of COPD. Also, with recent technological innovations, there has been a 12.1 % increase in the use of Noninvasive Mechanical Ventilation (NIV) for management of COPD. Along with technological advancements, use of digital radiography (X-ray) and advanced portable spirometers is gaining momentum in the respiratory disease testing/diagnostics market.

Gather more insights about the market drivers, restrains and growth of the Respiratory Disease Testing Market

Respiratory Disease Testing Market Report Highlights

• Growing prevalence of respiratory diseases and rapid technological advancements are two of the major factors expected to propel the market growth

• Based on products, imaging tests held the largest share in 2022 due to rapid development and adoption of innovative technologies

• Based on application, tuberculosis was the largest market in 2022 owing to rising prevalence of the disease globally

• Based on end-use, hospitals segment held the largest share in 2022 and is anticipated to grow over the forecast period due to an increase in hospitalization and a growing preference for hospital treatment

• North America dominated the respiratory disease testing market in 2022. Growing prevalence of respiratory diseases such as COPD, & asthma, increasing demand for early diagnosis, and rising awareness amongst patients about the benefits of early diagnosis are responsible for the dominance

• Asia Pacific region is expected to grow at the fastest rate during the forecast period. This growth can be attributed to various factors, such as improving healthcare infrastructure and increasing patient awareness regarding the availability of new diagnostic techniques for respiratory diseases, such as COPD & asthma

• Some of the major players competing in this market include, but are not limited to, Becton Dickinson (Carefusion Corporation); Koninklijke Philips N.V. (Respironics); ResMed Company; Fischer & Paykel; and Medtronic. These players are strong brands in the market as they have elaborate product portfolios in respiratory disease diagnostics market

Respiratory Disease Testing Market Segmentation

Grand View Research has segmented the global respiratory disease testing market on the basis of product, application, end-use, and region:

Respiratory Disease Testing Market Product Outlook (Revenue, USD Million, 2018 - 2030)

• Imaging Tests

• Respiratory Measurement Devices

• Blood Gas Test

• Others

Respiratory Disease Testing Market Application Outlook (Revenue, USD Million, 2018 - 2030)

• Chronic Obstructive Pulmonary Disease

• Lung Cancer

• Asthma

• Tuberculosis

• Other

Respiratory Disease Testing Market End-use Outlook (Revenue, USD Million, 2018 - 2030)

• Hospital

• Physicians Clinic

• Clinical Laboratories

• Other

Respiratory Disease Testing Market Regional Outlook (Revenue, USD Million, 2018 - 2030)

• North America

o U.S.

o Canada

• Europe

o UK

o Germany

o France

o Italy

o Spain

o Sweden

o Norway

o Denmark

• Asia Pacific

o Japan

o China

o India

o Australia

o Thailand

o South Korea

• Latin America

o Brazil

o Mexico

o Argentina

• Middle East and Africa

o Saudi Arabia

o South Africa

o UAE

o Kuwait

Order a free sample PDF of the Respiratory Disease Testing Market Intelligence Study, published by Grand View Research.

[ambitbiomedixin]

How Does A Cosmetic Dentist Fix Cracked And Chipped Teeth?

A cracked or chipped tooth can disrupt more than just the aesthetics of your smile—it can affect your confidence, oral health, and overall well-being. Whether caused by an accident, biting into something hard, or general wear and tear, addressing dental damage promptly is crucial. 

Thankfully, a cosmetic dentist in Joondalup specialises in restoring damaged teeth to their natural beauty and function. Here’s how they approach the task with precision and professionalism.

Comprehensive Assessment and Diagnosis

The journey to repairing a cracked or chipped tooth begins with a thorough examination. A professional cosmetic dentist will evaluate the extent of the damage using tools like digital imaging or X-rays. 

This step ensures they understand whether the issue is superficial or if it extends deeper into the tooth’s structure.

Why Assessment is Crucial

Prevents complications: Identifies hidden fractures or underlying dental concerns.

Tailored solutions: Helps determine the most suitable treatment approach.

Long-term success: Ensures the restoration is durable and effective.

Dental Bonding for Minor Repairs

Dental bonding is an efficient and noninvasive solution for minor chips. This procedure involves applying a tooth-coloured composite resin to the damaged area. 

The resin is shaped, hardened under a special light, and polished to blend seamlessly with the natural tooth.

Benefits of Bonding

Quick procedure: Typically completed in a single visit.

Natural appearance: Matches the colour and texture of your teeth.

Cost-effective: Ideal for minor cosmetic issues.

Veneers for Enhanced Aesthetics

When the damage is more extensive, veneers offer a versatile and long-lasting solution. Veneers are thin shells made of porcelain or composite resin custom-crafted to cover the tooth's front surface.

Why Veneers Stand Out

Comprehensive coverage: Conceals cracks, chips, and discoloration.

Durable material: Resistant to stains and wear.

Custom design: A cosmetic dentist in Joondalup will ensure the veneers align perfectly with your smile’s natural shape and colour.

Crowns for Structural Integrity

Severe cracks compromising the tooth’s strength require a more robust solution, such as a crown. A crown encases the entire tooth, restoring its function, strength, and appearance.

Advantages of Crowns

Full protection: Shields the tooth from further damage.

Functional restoration: Allows normal biting and chewing.

Long-lasting: High-quality crowns are designed to endure daily wear and tear.

Modern dental technology enables crowns to be created with materials that mimic the translucency and texture of natural teeth, ensuring a flawless result.

Enamel Contouring for Subtle Adjustments

Enamel contouring may be recommended for minimal chips or rough edges. This process involves reshaping the tooth by gently removing small amounts of enamel. It’s a simple yet effective way to refine the tooth’s appearance without invasive measures.

Advanced Solutions for Severe Cases

In cases where cracks extend into the root or severely weaken the tooth, additional treatments may be required. These might include:

Root canal therapy: To address damage that affects the tooth’s pulp.

Dental implants: For cases where the tooth is beyond repair.

Your cosmetic dentist in Joondalup will guide you through these options to ensure the best outcome for functionality and aesthetics.

Proactive Tips to Prevent Dental Damage

While skilled cosmetic dentists can repair most issues, prevention is always better than cure. Here are a few ways to protect your teeth:

Avoid chewing hard objects like ice, pens, or fingernails.

Wear a mouthguard during sports or high-impact activities.

Address teeth grinding or clenching with a dentist’s help.

Restoring Confidence Through Expert Care

Cracked and chipped teeth no longer have to be a source of discomfort or self-consciousness. With advanced techniques and materials, a cosmetic dentist in Joondalup can repair and restore your teeth, enhancing appearance and oral health.

Don’t let dental imperfections hold you back. Schedule an appointment today and take the first step toward a confident, radiant smile.

Source: How Does a Cosmetic Dentist Fix Cracked And Chipped Teeth?

[jeevanrekhablog]

Comprehensive Neurological Care for a Better Tomorrow

Neurology is an important branch of medicine devoted to the diagnosis, treatment and management of neurological disorders. This complex system, which includes the brain, spinal cord, and peripheral nervous system, governs vital functions such as movement, perception, and perception Proper neurologic care is essential to ensure that they all do well, especially for those affected by neurological conditions. Neurology Hospital in jaipur stands as a beacon of hope for patients seeking expert care and state-of-the-art treatment for neurological disorders.

Understanding Neurological Conditions

Arthritis varies greatly, affecting individuals differently depending on their age and overall health. Common conditions include:

Fractures: Prompt medical treatment is essential to minimize damage and promote recovery.

Epilepsy: A chronic neurological disorder associated with recurrent epilepsy, managed by elective medication or surgery.

Parkinson's disease: a progressive disorder affecting movement, treated with drugs and therapies.

Dementia: Conditions such as Alzheimer’s require close monitoring to maintain cognitive decline.

Treatment Options

Advanced diagnostic tools such as MRI, CT scan and EEG are treated at the state-of-the-art best hospital in Jaipur to diagnose the causes of neurological disorders Neurological treatments include:

Drug therapy: Needed to manage chronic conditions such as colds or flu.

Neural Rehabilitation: For conditions such as stroke, the focus will be on restoring motor function and cognitive abilities.

Noninvasive surgery: Advanced techniques for tumor, lymph node, or vascular repair.

Commitment to Holistic Care

Rheumatoid arthritis does not end with diagnosis. These clinics emphasize holistic medicine, offering counseling, support groups and lifestyle modifications to ensure long-term wellness.

[willyskristina]

Radiotherapy Market

Radiotherapy Market Size, Share, Trends: Varian Medical Systems (Siemens Healthineers) Leads

Adoption of advanced radiotherapy techniques drives precision and efficacy

Market Overview: 

The global Radiotherapy Market is projected to grow at a CAGR of XX% from 2024 to 2031, with the market value expected to rise from USD XX billion in 2024 to USD YY billion by 2031.

North America currently dominates the market, driven by advanced healthcare infrastructure and high cancer prevalence. Key metrics include increasing cancer incidence rates, technological advancements in radiation therapy equipment, and growing adoption of combination therapies.

The radiation market is rapidly developing, driven by rising cancer diagnoses worldwide and continued advances in treatment delivery technologies. Precision medicine and the application of artificial intelligence in treatment planning are changing the landscape, promising improved patient outcomes with fewer side effects.

DOWNLOAD FREE SAMPLE

Market Dynamics: 

The radiation market is undergoing a rapid shift towards more advanced treatments. Intensity-modulated radiation treatment (IMRT) and image-guided radiation therapy (IGRT) are gaining popularity due to their ability to provide precise radiation doses to tumors while sparing healthy tissue. These novel approaches offer personalized treatment strategies that adapt to tumor changes during therapy.

Market Segmentation: 

External Beam Radiation Therapy (EBRT) dominates the radiotherapy market, accounting for the largest market share in terms of revenue and treatment volume.

External Beam Radiation Therapy is the foundation of radiation therapy, enabling flexibility in treating a wide range of cancer types and locations. The segment's dominance stems from its noninvasive nature, ability to treat deep-seated tumors, and continual technological advancements. Linear accelerators (LINACs), the major EBRT equipment, have shown substantial improvements in precision and efficiency.

Market Key Players:

Varian Medical Systems (Siemens Healthineers)

Elekta AB

Accuray Incorporated

IBA (Ion Beam Applications)

ViewRay, Inc.

Hitachi, Ltd.

Contact Us:

Name: Hari Krishna

Email us: hari.krishna@aurorawaveintellects.com

Website: https://aurorawaveintellects.com/

[sunaleisocial]

Noninvasive imaging method can penetrate deeper into living tissue

New Post has been published on https://sunalei.org/news/noninvasive-imaging-method-can-penetrate-deeper-into-living-tissue/

Noninvasive imaging method can penetrate deeper into living tissue

Metabolic imaging is a noninvasive method that enables clinicians and scientists to study living cells using laser light, which can help them assess disease progression and treatment responses.

But light scatters when it shines into biological tissue, limiting how deep it can penetrate and hampering the resolution of captured images.

Now, MIT researchers have developed a new technique that more than doubles the usual depth limit of metabolic imaging. Their method also boosts imaging speeds, yielding richer and more detailed images.

This new technique does not require tissue to be preprocessed, such as by cutting it or staining it with dyes. Instead, a specialized laser illuminates deep into the tissue, causing certain intrinsic molecules within the cells and tissues to emit light. This eliminates the need to alter the tissue, providing a more natural and accurate representation of its structure and function.

The researchers achieved this by adaptively customizing the laser light for deep tissues. Using a recently developed fiber shaper — a device they control by bending it — they can tune the color and pulses of light to minimize scattering and maximize the signal as the light travels deeper into the tissue. This allows them to see much further into living tissue and capture clearer images.

This animation shows deep metabolic imaging of living intact 3D multicellular systems, which were grown in the Roger Kamm lab at MIT. The clearer side is the result of the researchers’ new imaging method, in combination with their previous work on physics-based deblurring.

Credit: Courtesy of the researchers

Greater penetration depth, faster speeds, and higher resolution make this method particularly well-suited for demanding imaging applications like cancer research, tissue engineering, drug discovery, and the study of immune responses.

“This work shows a significant improvement in terms of depth penetration for label-free metabolic imaging. It opens new avenues for studying and exploring metabolic dynamics deep in living biosystems,” says Sixian You, assistant professor in the Department of Electrical Engineering and Computer Science (EECS), a member of the Research Laboratory for Electronics, and senior author of a paper on this imaging technique.

She is joined on the paper by lead author Kunzan Liu, an EECS graduate student; Tong Qiu, an MIT postdoc; Honghao Cao, an EECS graduate student; Fan Wang, professor of brain and cognitive sciences; Roger Kamm, the Cecil and Ida Green Distinguished Professor of Biological and Mechanical Engineering; Linda Griffith, the School of Engineering Professor of Teaching Innovation in the Department of Biological Engineering; and other MIT colleagues. The research appears today in Science Advances.

Laser-focused

This new method falls in the category of label-free imaging, which means tissue is not stained beforehand. Staining creates contrast that helps a clinical biologist see cell nuclei and proteins better. But staining typically requires the biologist to section and slice the sample, a process that often kills the tissue and makes it impossible to study dynamic processes in living cells.

In label-free imaging techniques, researchers use lasers to illuminate specific molecules within cells, causing them to emit light of different colors that reveal various molecular contents and cellular structures. However, generating the ideal laser light with certain wavelengths and high-quality pulses for deep-tissue imaging has been challenging.

The researchers developed a new approach to overcome this limitation. They use a multimode fiber, a type of optical fiber which can carry a significant amount of power, and couple it with a compact device called a “fiber shaper.” This shaper allows them to precisely modulate the light propagation by adaptively changing the shape of the fiber. Bending the fiber changes the color and intensity of the laser.

Building on prior work, the researchers adapted the first version of the fiber shaper for deeper multimodal metabolic imaging.

“We want to channel all this energy into the colors we need with the pulse properties we require. This gives us higher generation efficiency and a clearer image, even deep within tissues,” says Cao.

Once they had built the controllable mechanism, they developed an imaging platform to leverage the powerful laser source to generate longer wavelengths of light, which are crucial for deeper penetration into biological tissues.

“We believe this technology has the potential to significantly advance biological research. By making it affordable and accessible to biology labs, we hope to empower scientists with a powerful tool for discovery,” Liu says.

Dynamic applications

When the researchers tested their imaging device, the light was able to penetrate more than 700 micrometers into a biological sample, whereas the best prior techniques could only reach about 200 micrometers.

“With this new type of deep imaging, we want to look at biological samples and see something we have never seen before,” Liu adds.

The deep imaging technique enabled them to see cells at multiple levels within a living system, which could help researchers study metabolic changes that happen at different depths. In addition, the faster imaging speed allows them to gather more detailed information on how a cell’s metabolism affects the speed and direction of its movements.

This new imaging method could offer a boost to the study of organoids, which are engineered cells that can grow to mimic the structure and function of organs. Researchers in the Kamm and Griffith labs pioneer the development of brain and endometrial organoids that can grow like organs for disease and treatment assessment.

However, it has been challenging to precisely observe internal developments without cutting or staining the tissue, which kills the sample.

This new imaging technique allows researchers to noninvasively monitor the metabolic states inside a living organoid while it continues to grow.

With these and other biomedical applications in mind, the researchers plan to aim for even higher-resolution images. At the same time, they are working to create low-noise laser sources, which could enable deeper imaging with less light dosage.

They are also developing algorithms that react to the images to reconstruct the full 3D structures of biological samples in high resolution.

In the long run, they hope to apply this technique in the real world to help biologists monitor drug response in real-time to aid in the development of new medicines.

“By enabling multimodal metabolic imaging that reaches deeper into tissues, we’re providing scientists with an unprecedented ability to observe nontransparent biological systems in their natural state. We’re excited to collaborate with clinicians, biologists, and bioengineers to push the boundaries of this technology and turn these insights into real-world medical breakthroughs,” You says.

“This work is exciting because it uses innovative feedback methods to image cell metabolism deeper in tissues compared to current techniques. These technologies also provide fast imaging speeds, which was used to uncover unique metabolic dynamics of immune cell motility within blood vessels. I expect that these imaging tools will be instrumental for discovering links between cell function and metabolism within dynamic living systems,” says Melissa Skala, an investigator at the Morgridge Institute for Research who was not involved with this work.

“Being able to acquire high resolution multi-photon images relying on NAD(P)H autofluorescence contrast faster and deeper into tissues opens the door to the study of a wide range of important problems,” adds Irene Georgakoudi, a professor of biomedical engineering at Tufts University who was also not involved with this work. “Imaging living tissues as fast as possible whenever you assess metabolic function is always a huge advantage in terms of ensuring the physiological relevance of the data, sampling a meaningful tissue volume, or monitoring fast changes. For applications in cancer diagnosis or in neuroscience, imaging deeper — and faster — enables us to consider a richer set of problems and interactions that haven’t been studied in living tissues before.”

This research is funded, in part, by MIT startup funds, a U.S. National Science Foundation CAREER Award, an MIT Irwin Jacobs and Joan Klein Presidential Fellowship, and an MIT Kailath Fellowship.