#nanocarriers

[dangerdust2]

The hope is that a drop of solution containing these nanocarriers, delivered to the lungs via the nose, could treat acute respiratory distress syndrome (ARDS), one of the most frequent causes of respiratory failure that leads to putting patients on a ventilator. In ARDS, inflammation spiraling out of control in the lungs so seriously burdens the immune system that immune cells are unable to tend to the initial cause of the damage.

[darkmaga-returns]

By Nicolas Hulscher, MPH

A new study titled, Nanocarrier imaging at single-cell resolution across entire mouse bodies with deep learning, was just published in Nature Biotechnology:

Efficient and accurate nanocarrier development for targeted drug delivery is hindered by a lack of methods to analyze its cell-level biodistribution across whole organisms. Here we present Single Cell Precision Nanocarrier Identification (SCP-Nano), an integrated experimental and deep learning pipeline to comprehensively quantify the targeting of nanocarriers throughout the whole mouse body at single-cell resolution. SCP-Nano reveals the tissue distribution patterns of lipid nanoparticles (LNPs) after different injection routes at doses as low as 0.0005 mg kg−1—far below the detection limits of conventional whole body imaging techniques. We demonstrate that intramuscularly injected LNPs carrying SARS-CoV-2 spike mRNA reach heart tissue, leading to proteome changes, suggesting immune activation and blood vessel damage. SCP-Nano generalizes to various types of nanocarriers, including liposomes, polyplexes, DNA origami and adeno-associated viruses (AAVs), revealing that an AAV2 variant transduces adipocytes throughout the body. SCP-Nano enables comprehensive three-dimensional mapping of nanocarrier distribution throughout mouse bodies with high sensitivity and should accelerate the development of precise and safe nanocarrier-based therapeutics.

[kramlabs]

“The study’s findings reveal the third structural problem with mRNA. Until those structural problems are solved, or even addressed, mRNA risks becoming nothing more than a forgettable footnote in the sordid history of scientific failure: a tragic tale of overpromised innovation and blind faith in cutting-edge technology, calamitously unraveled by unmet safety and efficacy standards.”

Commentary Link

[theresa-of-liechtenstein]

a student from my talk at my old high school emailed me thanking me for talking to them and asked a couple of questions but also said someone like me, "who has been so successful at such a young age," is an inspiration to her.

which is a really strange feeling because, if you were to ask me, i wouldn't say i'm much of an inspiration. i'm literally at the bottom of the pecking order, conducting a literature search for more than an hour at a time gives me a headache, and if you were to ask me to design a novel experiment related to converting bacteriophages into nanocarriers my mind is a huge fucking blank. and all of this is so insidious because i know it doesn't appear that way from the outside. i have public speaking and writing skills that make it look like i have everything together and that i'm a qualified candidate for this, even though i'm scrambling for survival right now and terrified that the preliminary exams eight to nine months from now are going to reveal just how much i don't deserve any of this money and access to buildings and facilities and supplies.

my grandfather was the dean of a university that was written off in his time. my mother went to a nursing college that got less-than-complimentary reactions. my father's world was constrained to a couple square miles of farmland for the first decade or so of his life. nobody in my family is a genius and neither am i. i have never been so scared in my whole entire life

[onlymollygibson]

Im no expert but I'm a grad student working on a paper in this field.

Cancer is a bunch of diseases lumped togethet, so there will never be a one size fits all cure, just better and better treatments.

That said, the current treatments in the pipeline are incredible.

Cancer vaccines like the article talks about. Basically tumors exist because the immune system doesn't notice them as foreign or diseased, or it does notice but can't fight them because the tumor is actively suppressing the immune system. Cancer vaccines train your body's natural defenses to kill the cancer cells. Chefs kiss! Incredible science. Note that they surgically removed most of the tumor first in this trial, so it's a case of doing most of the work in surgery and letting your immune system do the cleanup.

Theyre finding in general that modern therapies like cancer vaccines or other immune boosting treatments work best in synchrony with other treatments (chemo, radiation, surgery) to get the last little bits that aren't taken out by surgery, or are resistant to chemo, etc. Immunotherapy doesn't necessarily do great at getting into tumors and wiping them out all on its own, but it's fantastic at killing the last remnants and prolonging remission or ensuring the cancer doesn't come back at all.

Some other cool immunotherapies and nanomedicines for cancer in the works (some are approved, some are still being developed.)

CAR T cells - remove white blood cells from the body, train them to attack the cancer and put them back in. Seriously look it up if you want your mind blown. This won the Nobel prize a few years back.

Nanocarriers for drugs- a big problem of cancer medicines is targeting - how do we kill the cancer while not harming the rest of the body too much. They're designing nano and micro scale encapsulation for drugs that get them to the cancer, either through direct chemical targeting or by taking advantage of the structural differences of tumors like blood vessels that are "leaky," meaning they let stuff through that non-tumor blood vessels don't. Some formulations are designed to decrease liver accumulation, or hide from the immune system. Early stages still but expect to see great things. They're trying everything from metal nanoparticles to cell membrane derived drug packaging to DNA origami. It's incredible.

Other immunotherapies: basically anything that activates the immune system to turn on the cancer. Everything from the aforementioned cancer vaccines, to cytokines (like hormones but for the immune system), to little "backpacks" made out of lipids that attach to tumor infiltrating lymphocytes (white blood cells that can get into the tumor) and deliver immune activating factors straight into the tumor by tagging along with cells that are going in anyways.

There's more but I have to analyze data now. Science is incredible!

The discovery represents a potential new way to recruit the immune system to fight treatment-resistant cancers using an iteration of mRNA technology and lipid nanoparticles, similar to COVID-19 vaccines, but with two key differences: use of a patient’s own tumor cells to create a personalized vaccine, and a newly engineered complex delivery mechanism within the vaccine.

Within 48 hours, the four human study participants showed remarkable results: their immune systems went into turbo cancer-destroying mode. And without surgery, radiation, or dangerous chemotherapy.

Folks, we may have a cure for cancer within your lifetime.

[visionaryvogues03]

How Nanotechnology is Revolutionizing Healthcare?

Nanotechnology was regarded as an element of science fiction, some years ago. The rise of nanotechnology has transformed several industries that have created devices that are several times smaller than one can imagine. This technology is revolutionizing healthcare in many ways. It has changed the face of drug delivery providing an effective & targeted delivery of drugs that minimizes side effects & increases the therapeutic efficacy of the drugs. 

What is Nanotechnology in Healthcare?

At its core, nanotechnology involves the engineering of materials and devices at a scale of 1 to 100 nanometers. To put it in perspective, a single strand of human DNA is about 2.5 nanometers in diameter. In healthcare, this minuscule scale allows for unprecedented precision in addressing medical challenges, from delivering drugs to targeting specific cells.

Precision Drug Delivery: A New Era in Treatment

One of the most notable ways nanotechnology is revolutionizing healthcare is through precision drug delivery. Traditional methods of administering medication often result in systemic side effects because drugs interact with both diseased and healthy cells. Nanotechnology offers a solution by enabling targeted delivery. Nanoparticles can be designed to deliver drugs directly to cancer cells, minimizing damage to healthy tissue and enhancing therapeutic outcomes. This approach is already showing promise in treating aggressive diseases like cancer and autoimmune disorders.

Moreover, nanotechnology enables the development of smart drug delivery systems that release medication only when needed. These systems respond to specific triggers, such as changes in temperature or pH levels, ensuring optimal therapeutic effects while reducing waste. For example, chemotherapy drugs delivered through nanocarriers can be released precisely at the tumor site, significantly reducing harmful side effects.

Advances in Diagnostics: Early Detection Saves Lives

Nanotechnology is transforming diagnostics by making early detection of diseases more accurate and accessible. Nanosensors and lab-on-a-chip devices can detect biomarkers of diseases such as cancer, Alzheimer’s, and infectious diseases at their earliest stages. For instance, liquid biopsies using nanotechnology can identify cancerous cells in the bloodstream long before symptoms appear, enabling timely intervention. This shift from reactive to proactive healthcare is revolutionizing healthcare delivery.

Furthermore, nanoscale imaging technologies are enhancing the resolution and accuracy of diagnostic tools. Quantum dots, for example, are being used to improve the visualization of biological processes in real-time, providing clinicians with invaluable insights for decision-making.

Regenerative Medicine: Healing from Within

The role of nanotechnology in regenerative medicine is another frontier revolutionizing healthcare. Nanomaterials are being used to create scaffolds that mimic the body’s natural extracellular matrix, promoting the growth of new tissues and organs. This technology holds immense potential for treating injuries, repairing damaged tissues, and even growing entire organs for transplantation.

Additionally, nanotechnology is enabling advancements in stem cell therapy. Nanoparticles can be used to guide stem cells to specific sites in the body, improving their efficacy in repairing damaged tissues. This precision is revolutionizing healthcare by making regenerative treatments more effective and predictable.

Combatting Antimicrobial Resistance

Antimicrobial resistance is a growing global health crisis, but nanotechnology is offering innovative solutions. Nanoparticles with antimicrobial properties, such as silver and zinc oxide, are being integrated into wound dressings, medical devices, and coatings to prevent infections. These advancements are revolutionizing healthcare by reducing the threat of drug-resistant pathogens in clinical settings.

Moreover, nanotechnology is paving the way for the development of new antibiotics. Nanostructures can be engineered to disrupt bacterial membranes, effectively neutralizing resistant strains without relying on traditional antibiotics.

The Role of Nanotechnology in Vaccines

Nanotechnology is playing a critical role in vaccine development and delivery, especially in the fight against emerging infectious diseases. Nanoparticles can be engineered to enhance the stability and efficacy of vaccines, ensuring that they are effective even in challenging environments. For example, lipid nanoparticles were instrumental in delivering mRNA vaccines during the COVID-19 pandemic, showcasing how nanotechnology is revolutionizing healthcare on a global scale.

In addition, nanotechnology is enabling the creation of next-generation vaccines that target multiple strains of viruses. These universal vaccines could revolutionize healthcare by providing long-lasting protection against rapidly mutating pathogens.

Challenges and Ethical Considerations

While nanotechnology is revolutionizing healthcare, it also presents challenges. The long-term effects of nanoparticles in the human body and the environment are still not fully understood. Additionally, the high cost of developing and scaling nanotechnology solutions poses barriers to widespread adoption. Ethical considerations, such as patient privacy and equitable access, must also be addressed as the technology advances.

Regulatory frameworks must evolve to keep pace with these innovations, ensuring that nanotechnology applications in healthcare are safe, effective, and accessible. Collaborative efforts between governments, industry, and academia will be crucial in overcoming these challenges.

Implications for Businesses and Startups

For businesses and startups, nanotechnology represents a fertile ground for innovation and investment. From developing next-generation medical devices to creating targeted therapies, opportunities abound for those willing to explore this frontier. Strategic partnerships with research institutions and a focus on sustainable practices can position companies as leaders in this transformative space.

Nanotechnology also offers significant opportunities for cost savings in healthcare. By enabling more precise treatments and reducing the need for invasive procedures, it has the potential to lower overall healthcare costs, making it an attractive area for investment.

The Future of Nanotechnology in Healthcare

As research progresses, the potential of nanotechnology in healthcare continues to expand. Future advancements may include nanoscale robots capable of performing surgeries inside the body, wearable devices that provide real-time health monitoring, and personalized treatments tailored to an individual’s genetic makeup. The integration of artificial intelligence with nanotechnology could further accelerate these developments, making healthcare smarter and more efficient.

For example, nanobots could one day be used to deliver therapies at the cellular level, repairing damaged tissues or even reversing the effects of aging. Wearable devices embedded with nanosensors could continuously monitor a patient’s health, alerting them to potential issues before symptoms arise.

Conclusion

Nanotechnology is undeniably revolutionizing healthcare, offering solutions to some of the most pressing medical challenges of our time. From precision drug delivery to regenerative medicine, its applications are transforming patient care and redefining industry standards. For leaders in the business and startup world, understanding and leveraging these advancements is key to driving innovation and staying competitive in an evolving marketplace. As the boundaries of what is possible continue to expand, nanotechnology will remain at the forefront of healthcare’s revolutionary journey.

By embracing this transformative technology, the healthcare industry can achieve unprecedented levels of precision, efficiency, and accessibility, paving the way for a healthier and more sustainable future.

Uncover the latest trends and insights with our articles on Visionary Vogues

[themalriclabs]

Nanotechnology in Neuro-Oncology: Targeted Drug Delivery for Glioblastoma Multiforme (2019)

ABSTRACT.

This paper explores the advancements in nanomedicine to address the challenges of treating glioblastoma multiforme (GBM), an aggressive and treatment-resistant brain tumor. The study focuses on the use of nanocarriers, such as liposomes, polymeric nanoparticles, and dendrimers, to enhance the precision and efficacy of drug delivery across the blood-brain barrier. By utilizing nanoscale targeting mechanisms, including surface modifications and ligand-receptor binding, these systems improve the delivery of chemotherapeutic agents directly to tumor sites while minimizing systemic toxicity. Preclinical and early clinical results indicate a significant increase in drug bioavailability and tumor uptake, along with reduced adverse effects. This article highlights nanotechnology's transformative potential in neuro-oncology and provides a foundation for future research toward personalized and effective GBM treatment strategies.

[lovelypol]

"Pharmaceutical Excipients Market: Innovating Drug Formulations for a Healthier Future by 2025"

Pharmaceutical Excipients Market : Pharmaceutical excipients may not grab the spotlight, but they play a critical role in the effectiveness, stability, and safety of medications. These inactive substances serve as carriers, stabilizers, or enhancers in drug formulations, ensuring the active pharmaceutical ingredient (API) performs optimally. From improving the taste and shelf life of oral medications to enabling targeted delivery in complex formulations like sustained-release capsules, excipients are indispensable in modern drug development. Their versatility spans diverse forms, including binders, fillers, disintegrants, and lubricants, each tailored to meet specific therapeutic needs.

To Request Sample Report : https://www.globalinsightservices.com/request-sample/?id=GIS20190 &utm_source=SnehaPatil&utm_medium=Article

With the rise of biologics, personalized medicine, and novel drug delivery systems, the demand for innovative excipients has never been higher. Biodegradable polymers, nanocarriers, and multifunctional excipients are shaping the future of pharmaceuticals, addressing challenges such as solubility enhancement and controlled drug release. As regulatory scrutiny intensifies, pharmaceutical companies are prioritizing high-quality, safe, and sustainable excipients. These advancements are driving a paradigm shift, transforming excipients from passive ingredients to active enablers of cutting-edge medical solutions

#PharmaceuticalExcipients #DrugFormulation #PharmaInnovation #SustainablePharma #ExcipientTechnology #BiologicsSupport #TargetedDrugDelivery #NovelExcipients #MedicalBreakthroughs #DrugDevelopment #ControlledRelease #SolubilityEnhancement #PharmaFuture #HealthTech #PharmaceuticalScience

[colinwilson11]

The global blood brain barrier market offers potential advantages of delivering therapeutic drugs directly to the brain while reducing systemic exposure. Products like nanocarriers and nanoparticles help improve the pharmacokinetics and biodistribution of drugs. The blood brain barrier presents major challenges for treating many neurological disorders by restricting the passage of molecules from circulating blood into the extracellular fluid of the central nervous system.

[kramlabs]

[ribosome-papers]

Engineered chitosan-derived nanocarrier for efficient siRNA delivery to peripheral and central neurons

bioRxiv: http://dlvr.it/TD4Lbj

[crimsonpublisherscancerstudy]

Synergistic Power of Phytochemicals and Nanotechnology in Cancer Treatment_Crimson Publishers

Abstract Bioactive Phytocompounds (BPCs) naturally found in plants, hold immense potential for cancer treatment. However, their limitations like poor solubility, bioavailability and stability hinder their effectiveness. This review explores how nanotechnology can overcome these limitations and empower phytochemicals in the fight against drug-resistant cancer. Despite advancements, conventional therapies (surgery, radiation, chemotherapy) often suffer from side effects and drug resistance. Understanding the complex signaling pathways involved in cancer development is crucial for designing targeted therapies. Phytochemicals offer diverse biological activities against cancer, but their inherent limitations restrict their use. They can induce apoptosis, inhibit growth, modulate inflammation, and bolster the immune response. Nanocarriers encapsulating phytochemicals enhance their solubility, stability, and bioavailability, enabling targeted delivery to cancer cells while minimizing harm to healthy tissues. Intricate nanocarriers are programmed for controlled release and specific targeting based on cancer cell markers. Although phytochemicals exhibit diverse anti-cancer activities, their limitations restrict their use. Nanotechnology offers a game-changer, enhancing solubility, and stability, and enabling targeted delivery to cancer cells, minimizing harm to healthy tissues. Exciting future advancements include intricate nanocarriers programmed for controlled release and personalized therapy tailored to individual patients. This intersection of phytochemicals, cancer research, and nanotechnology offers a beacon of hope, paving the way for personalized, safe, and effective therapies, bringing us closer to a world free from the devastating effects of drug-resistant cancer.

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