#mullaly

[detournementsmineurs]

Nick Offerman et Megan Mullally dans "Umbrella Academy (Saison 4)” série de Steve Blackman - adaptée des comics éponymes du musicien Gerard Way et de Gabriel Bá, publiées par Dark Horse Comics (2007-08) - septembre 2024.

[lavenderplasticbag]

Nick Mullaly - Performance, 2023, oil on canvas, 81 cm x 86 cm

[johnstevenmullaly]

The Impact of Gene Therapy on Modern Medicine

Gene therapy is a groundbreaking approach in medical science. It offers hope to many patients suffering from genetic disorders and other diseases. The aim of gene therapy is to provide long-lasting and potentially curative treatments by targeting the root cause of these ailments at the genetic level. This approach highlights a significant transformative impact on modern medicine.

Gene therapy involves introducing, altering, or removing genes within an individual's cells to treat or prevent disease. The two primary types are somatic gene therapy, which targets nonreproductive cells, and germline gene therapy, which affects reproductive cells and can be passed on to future generations. Techniques such as viral vectors, which deliver new genes to cells, and CRISPR-Cas9, a precise gene-editing tool, have revolutionized this field, enabling more accurate and efficient genetic modifications.

The journey of gene therapy began in the early 1970s with foundational research that paved the way for its clinical application. However, it was not until 1990 that a significant milestone was achieved. This was when the first successful gene therapy procedure was performed on a young girl with severe combined immunodeficiency (SCID). This landmark event demonstrated the potential of gene therapy to cure genetic disorders. Since then, there have been a number of clinical trials conducted, leading to the development of therapies for various other conditions.

Gene therapy has shown huge potential in treating a range of genetic disorders. For instance, in cystic fibrosis, a condition caused by a defective gene, gene therapy aims to introduce a functional copy of the gene into the patient's lungs. Similarly, in muscular dystrophy, gene therapy seeks to restore the missing or defective dystrophin protein in muscle cells.

Cancer treatment has also seen remarkable advances through gene therapy. Techniques like CAR-T cell therapy, which modifies a patient's T cells to target cancer cells, have shown major success in treating certain types of leukemia and lymphoma. There is also ongoing research exploring gene therapy applications in neurological disorders like Parkinson's disease and cardiovascular diseases, expanding its potential reach.

One of the most important advantages of gene therapy is its likelihood to provide targeted and precision medicine. By addressing the underlying genetic cause, gene therapy can offer more effective and personalized treatments compared to traditional methods. This precision lessens the risk of side effects and enhances treatment outcomes.

Additionally, gene therapy holds the promise of curing previously untreatable conditions. For many genetic disorders, traditional treatments only manage symptoms without addressing the root cause. Gene therapy, on the other hand, offers the potential for a permanent cure, improving patients' quality of life and reducing long-term healthcare costs.

Some areas need improvement, and most gene therapies are still in clinical trials. This means that there are technical and scientific challenges that researchers are continually working to overcome. This includes effectively delivering therapeutic genes to the right cells, avoiding immune system reactions, and ensuring the long-term stability of the introduced genes.

Ethical concerns also arise, particularly with germline gene therapy, which can alter the genetic makeup of future generations. The implications of such modifications raise questions about consent, the potential for genetic enhancement, and the possibility of creating societal inequalities. Ensuring equitable access to these advanced therapies and navigating the regulatory landscape for approval and safety are crucial considerations for the future of gene therapy.

Regardless, the future of gene therapy is promising, with ongoing research and development opening new avenues for treatment. Advances in delivery methods, such as nanoparticles and improved viral vectors, aim to enhance the precision and efficiency of gene therapy. Researchers are also exploring the possibility of gene therapy to treat more complex conditions.

As technology evolves, gene therapy is expected to play an increasingly significant role in health care. There are expectations of having personalized medicine, where treatment is tailored to an individual's genetic makeup, offering hope for more effective interventions.

[chinchillasorchildren]

Films of 2023: Dicks: The Musical (dir. Larry Charles)

[giftideasfromaycaramba]

Carley uses humor and street smarts to keep her emotional walls high and thick. But the day she becomes a foster child, and moves in with the Murphys, she's blindsided. This loving, bustling family shows Carley the stable family life she never thought existed, and she feels like an alien in their cookie-cutter-perfect household. Despite her resistance, the Murphys eventually show her what it feels like to belong—until her mother wants her back and Carley has to decide where and how to live. She's not really a Murphy, but the gifts they've given her have opened up a new future.

[missams53]

2023 August TBR

Hello Readers: Can you believe that August is right around the corner? As I am typing up, I still have a few days of July left, but I decided it would be the perfect time to create August’s TBR. I will not be doing my wrap-up for July since I still have a few more days, and I would like to push myself to finish a couple more books.  Let us get started with this TBR.  Bridge of Souls by Victoria…

[young-dumb-and-vaccinated]

Okay I know I promised a rant, but it came out like a bunch of bullet points instead, so sorry.

The time skip was entirely unnecessary and makes the job of writing a finale harder

Having the umbrellas split up again undoes all of the character development up to this point

The relationships between the siblings have changed in the interim and needs to be explained through clunky expositional dialog

Why is there no learning curve after six years of not having powers?

There is no reason to include children and it actually works to the season's detriment

The children are non-entities and only exist to motivate Diego and Lila, just like Claire in season 1

The entirety of season 3 was just a testament to how bad at parenting Diego and Lila would be

Watching Diego and Lila bicker about domestic disputes is just boomer humor at this point

Your target audience of queer people do not want to see the people they're supposed to root for abandoning their children

It would have been both entertaining and entirely in character to keep the Diego/Lila dispute to suspected infidelity

Lila moonlights as a FBI agent but Diego thinks she's cheating so he goes through all the woman scorned tropes

This way it subverts the trope and gives us more opportunities to see duplicitous Lila and himbo Diego

I really thought Nick Offerman and Megan Mullaly would bring the energy, but no

I've never seen three hilarious people be so unfunny in my life

I cannot take David Cross seriously as a villain. He is so unthreatening.

Luther is the only one allowed to keep his character development and I just kinda wish they let him keep his wife

Allison is back to being an unrepentant bitch and does not earn the family's trust back

With a title like "the unbearable tragedy of getting what you want", I thought the episode would follow Allison trying to feel like she deserves to enjoy her life with Claire and Ray while dealing with the guilt of selling out her siblings

Considering that her entire season 3 arc was backsliding

But what it actually meant was okay I guess we'll never know

I heard a rumor??? Allison I think I heard a rumor about this guy?

Can we please give Klaus a break

Klaus can now clip into pushing daisies episodes

Klaus is trying to escape from his Angel Dust prison

Five looks like he's twelve

I'm always going to be suspicious of a showrunner that's trying to manufacture situations in which infidelity/incest is okay

Can we please give Viktor something to do

I do not blame him for fucking off to the middle of nowhere

Emmy for Elliot for depicting transmasc rageyt665ikju

I wish elliot would remove my marigold

Viktor has the power every autist secretly wants: to rule the fucking universe

Viktor between you and me I don't think this family is worth saving

Idk if Ben's arc is racist but it sure don't feel right

It's fuckin SHORTER. Why does it feel LONGER.

The no volume balancing is really fucking annoying

It would have been interesting to see hargreeves interacting with more than just one sibling at a time per season

Is being in your family like being stuck in a constant apocalyptic nightmare? You might just be transgender 

[run-of-the-milf]

Things I actually liked about TUA s4:

Discovery channel song

Viktor standing up to Reggie and their kinda bonding moments

Claire!

The holiday festival town with all the creepy people

The subway!!!

Lila's family

Megan Mullaly and Nick Offerman's characters

Viktor in general tbh

Alison crushing that pimp's nutsack

Things I didn't like about TUA s4:

The vomiting scene

Ben's entire character was unbearable

Whatever the fuck they did to Diego's character

Alison's "why am I always the bad guy" routine is getting old

Why did they even put in Klaus's sex trafficking plotline

Five & Lila getting lost in the subway

Ben & Jennifer's soulmate bullshit and the terrible cgi of the Cleanse

No buildup to the end, they just abruptly decided to kill themselves

"But I'm not that mean version of Reggie. I'm nice now, see! I have a wife and I'm nice to her and that makes all my abuse justified!"

Seriously why does it feel like they want us to feel sorry for Reginald at the end. It's his fault for impregnating their mothers with the marigold. He is the reason for all this.

[kwebtv]

Series Premiere

Where is Everybody - CBS - October 2, 1959

A presentation of "The Twilight Zone" Season 1 Episode 1

Anthology / Science Fiction

Running Time: 30 minutes

Hosted by Rod Serling

Cast:

Earl Holliman as Sgt Mike Ferris

James Gregory  as General

Paul Langton as Doctor

James McCallion as Reporter #1

John Conwell as Colonel

Jay Overholt as Reporter #2

Carter Mullaly as Captain

Garry Walberg as Reporter #3

Jim Johnson as Sergeant

This was the episode that sold the series to the sponsors.

[curly-capt]

Fish in a Tree by Lynda Mullaly Hunt ?

Hmm, I feel like I've heard of this one before! I'll check it out!

[detournementsmineurs]

"Umbrella Academy (Saison 4)” série de Steve Blackman - adaptée des comics éponymes du musicien Gerard Way et de Gabriel Bá, publiées par Dark Horse Comics (2007-08) - avec Aidan Gallagher, Ritu Arya, Robert Sheehan, Tom Hopper, David Castañeda, Emmy Raver-Lampman, Elliot Page, Justin H. Min, Colm Feore, Nick Offerman, Megan Mullally, Liisa Repo-Martell et Victoria Sawal, septembre 2024.

[lavenderplasticbag]

Pansies in the rain - Nick Mullaly

2024 oil on canvas 56 cm x 66 cm

[idratherstayinside6]

I forgot to mention something in my other post so I'll try and explain who I am more!

I am she/her and I sometimes play guitar. My favorite songs so far are

"Devil town"-By CaveTown.

"sailor song"-By Gigi Perez

I am Latina Americana. I have two best friends and so far my favorite books are

"You know me so well"- By Nina La'cor.

"Fish in a tree"- By Linda Mullaly Hunt.

My favorite Hazbin hotel ship is Chaggie and for Hellavaboss is Stolitz (I know their lowkey plain but I love em so much). Other ships I like are

-Huskerdust

-M&M

-Lucilith

-Guitarspear

-Luggie (AS EX'S [also Stephanie said they weren't exactly "Ex's" more like flings])

-Luzity

And of course no hate to other ships pls ship what you like just don't hate on mine. I am also Catholic. I'm trying to learn sailor song on guitar but so far I'm not so great at it. Also I'm not actually going to reveal my name so just call me R.

[johnstevenmullaly]

Different Types of Mountain Biking

Given the popularity of mountain biking, it should come as little surprise that today’s mountain bikers practice many styles of the sport. Equipment manufacturers have both accommodated and driven this diversification by offering bikes and gear to accommodate various mountain biking styles.

Most recreational mountain bikers initially gravitate toward trail riding. Trail mountain bikes place equal focus on uphill and downhill travel and are designed to balance performance with comfort.

Other types of mountain biking require more specialized bikes. Cross-country (XC) bikers who want to trade manicured trails for backcountry terrain will benefit from an XC bike with full-suspension and a more efficient gear system. If you want to ride on sand or snow, you will want a fat bike with oversize tires that can travel over soft and slick terrain.

Primarily practiced with the help of mechanical lifts, downhill mountain biking resembles downhill skiing in many ways. In fact, many ski resorts offer this thrilling and very fast activity during the summer months, taking the bikes to the top of the mountain on adapted ski lifts.

[uovoc]

2024 media consumption

God tier

The Husbands by Holly Gramazio - Lauren's attic creates an infinite supply of husbands. Deceptively simple exploration of commitment, indecision, and becoming whatever you choose.

Speaker for the Dead by Orson Scott Card (reread)

Ender's Game by Orson Scott Card (reread)

《仙王的日常生活》 (Daily Life of the Immortal King) - donghua, seasons 1-4. The most powerful cultivator in the universe just wants to get through high school as an ordinary teenager. An objectively average show. Yet its solid humor and heart of gold compelled me.

Season 5 of Scissor Seven (刺客伍六七), plus rewatch of seasons 1-4.

Welcome to Hell & Welcome to Hell 2 - indie shorts. Sock's first assignment as a new demon is to convince the world's most apathetic teenager to kill himself. Except that Sock is, like, really bad at his job. Cannot vouch for general crowd appeal but performs superbly as blorbo delivery vehicle.

Just ok

The Guncle by Steven Rowley

《我开动物园的那些年》 (Those Years I Opened a Zoo) - donghua, season 1

《长安三万里》 (30,000 Miles From Chang'an) - donghua

《小绿和小蓝》 (Beryl and Sapphire) - donghua. Fave: robo-Beryl arc.

Go For It, Nakamura! by Syundei - manga

Percy Jackson and the Olympians miniseries

Natsume's Book of Friends light novel

A Taste of Gold and Iron by Alexandra Rowland

The 2022 xxxHolic movie

Boy by Blake Nelson

The List of Things that Will Not Change by Rebecca Stead

The Prince of Venice Beach by Blake Nelson

Danny Phantom: A Glitch in Time by Gabriela Epstein - comic

Hazbin Hotel - 2024 cartoon

They Came From Below by Blake Nelson (reread)

Girl by Blake Nelson

Ducks: Two Years in the Oil Sands by Kate Beaton

《汉化日记》 (God Troubles Me) - donghua, season 4

Danny Phantom - cartoon (rewatch)

Ender in Exile by Orson Scott Card (reread) - at first I was disappointed because it wasn't Ender's Game and it wasn't Speaker for the Dead. But I gradually came to enjoy dumb teenage Ender with post-saving-the-world depression.

Ah! My Goddess by Fujishima Kosuke - manga (reread)

Shadow of the Hegemon by Orson Scott Card

2023 Gobelins senior thesis films. Fave: Childeric: Les Nerfs de la Guerre

Mon Ami Robot - movie

The Slow Regard of Silent Things by Patrick Rothfuss (reread)

《深海》 (Deep Sea) - donghua movie

Invisible Planets tr. Ken Liu (anthology)

《大护法》(Dahufa, also called The Guardian) - donghua movie

《大雨》 (The Storm) - donghua movie

The MDZS audiodrama

The Boy and the Heron - movie

Disliked and DNF

《嗜谎之神》 (God of Deception) - donghua

Warbreaker by Brandon Sanderson (reread)

Barbie - 2023 movie

Rosewater by Tade Thompson

My Name is Mina by David Almond

Gender Blender by Blake Nelson

Dungeon Meshi by Ryoko Kui - manga

Phoebe Will Destroy You by Blake Nelson

《大理寺日志：少卿游》 - White Cat Legend cdrama

Scavengers Reign - cartoon

Lily and the Octopus by Steven Rowley

Foundation by Isaac Asimov

Running Close to the Wind by Alexandra Rowland

The Celebrants by Steven Rowley

The Gospel of Loki by Joanne Harris

Xenocide by Orson Scott Card (reread)

The Witch's Heart by Genevieve Gornichec

Assorted nonfiction

Weird by Olga Khazan

Nonviolent Communication by Marshall Rosenberg

The Five Dysfunctions of a Team by Patrick Lencioni

Conflict is not Abuse by Sarah Schulman - DNF.

Strong Female Character by Fern Brady

Feeling Good Together by David Burns

Adult Children of Emotionally Immature Parents by Lindsay Gibson

Cathedral, Forge, and Waterwheel: Technology and Invention in the Middle Ages by Frances and Joseph Gies (reread). European and Asian medieval technologies and the social context driving their development. Good stuff on textile production.

Counselling Children, Adults, and Families: A Strengths-Based Approach by John Sharry. Therapy textbook: It's free therapy.

The New Structural Social Work by Bob Mullaly. DNF.

The Cloud Collector's Handbook by Gavin Pretor-Pinney

[angelmotifs]

fuck it. a few of the inductees in the sophia angelmotifs (emphasis on a few this is not extensive) hall of fame

river phoenix in my own private idaho

andrew garfield in angels in america

william h macy in magnolia

andy samberg in palm springs

walton goggins in the righteous gemstones

naomi watts in mulholland drive

marissa tomei in my cousin vinny

barbra streisand in what's up doc

christian bale in velvet goldmine

andrea riseborough in please baby please

megan mullaly in will and grace

donna murphy in passion