#interest rate news

[reasonsforhope]

A new treatment combining ReCET and semaglutide could eliminate the need for insulin in type 2 diabetes, with 86% of participants in a study no longer requiring insulin therapy. The treatment was safe and well-tolerated, and further trials are planned to confirm these results.

Groundbreaking research presented at UEG Week 2024 introduces a promising new treatment approach for type 2 diabetes (T2D) that has the potential to greatly reduce or even eliminate the need for insulin therapy.

This innovative approach, which combines a novel procedure known as ReCET (Re-Cellularization via Electroporation Therapy) with semaglutide, resulted in the elimination of insulin therapy for 86% of patients.

Globally, T2D affects 422 million people... While insulin therapy is commonly used to manage blood sugar levels in T2D patients, it can result in side effects... and further complicate diabetes management. [Note: Also very importantly it's fucking bankrupting people who need it!!] A need therefore exists for alternative treatment strategies.

Study Design and Outcomes

The first-in-human study included 14 participants aged 28 to 75 years, with body mass indices ranging from 24 to 40 kg/m². Each participant underwent the ReCET procedure under deep sedation, a treatment intended to improve the body’s sensitivity to its own insulin. Following the procedure, participants adhered to a two-week isocaloric liquid diet, after which semaglutide was gradually titrated up to 1mg/week.

Remarkably, at the 6- and 12-month follow-up, 86% of participants (12 out of 14) no longer required insulin therapy, and this success continued through the 24-month follow-up. In these cases, all patients maintained glycaemic control, with HbA1c levels remaining below 7.5%.

Tolerability and Safety

The maximum dose of semaglutide was well-tolerated by 93% of participants, one individual could not increase to the maximum dose due to nausea. All patients successfully completed the ReCET procedure, and no serious adverse effects were reported.

Dr Celine Busch, lead author of the study, commented, “These findings are very encouraging, suggesting that ReCET is a safe and feasible procedure that, when combined with semaglutide, can effectively eliminate the need for insulin therapy.”

“Unlike drug therapy, which requires daily medication adherence, ReCET is compliance-free [meaning: you don't have to take it every day], addressing the critical issue of ongoing patient adherence in the management of T2D. In addition, the treatment is disease-modifying: it improves the patient’s sensitivity to their own (endogenous) insulin, tackling the root cause of the disease, as opposed to currently available drug therapies, that are at best disease-controlling.”

Looking ahead, the researchers plan to conduct larger randomized controlled trials to further validate these findings. Dr. Busch added, “We are currently conducting the EMINENT-2 trial with the same inclusion and exclusion criteria and administration of semaglutide, but with either a sham procedure or ReCET. This study will also include mechanistic assessments to evaluate the underlying mechanism of ReCET.”

-via SciTechDaily, October 17, 2024

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Note: If it works even half as well as suggested, this could free so many people from the burden of the ongoing ridiculous cost of insulin. Pharma companies that make insulin can go choke (hopefully).

[go-to-two]

It's annoying when people see how much CPD has dropped and cry that it's because of the timeslot. It has been in the timeslot for a decade..... so

Yeah I'd say the discrepancy between live numbers for shows like Med and Fire (or other 8/9pm shows) compared to PD should factor in time slot.

But you can't deny PD has fallen when comparing it with itself over the years, in the same time slot. The ratings are all listed online. And again, the fall in ratings includes factors like the decline of network TV, natural falloff of audiences, competition, and changing mediums for entertainment. But if we're looking at external factors, it's only fair to look at internal as well for why people aren't sticking around anymore or are choosing other shows- the writing is weaker, the procedural cases are weaker, and the cast has lost major pieces over the years.

[dontmeantobepoliticalbut]

Former President Trump ran up the national debt by about twice as much as President Biden, according to a new analysis of their fiscal track records.

WHY IT MATTERS: The winner of November's election faces a gloomy fiscal outlook, with rapidly rising debt levels at a time when interest rates are already high and demographic pressure on retirement programs is rising.

• Both candidates bear a share of the responsibility, as each added trillions to that tally while in office.

• But Trump's contribution was significantly higher, according to the fiscal watchdogs at the Committee for a Responsible Federal Budget, thanks to both tax cuts and spending deals struck in his four years in the White House.

BY THE NUMBERS: Trump added $8.4 trillion in borrowing over a ten-year window, CRFB finds in a report out this morning.

• Biden's figure clocks in at $4.3 trillion with seven months remaining in his term.

• If you exclude COVID relief spending from the tally, the numbers are $4.8 trillion for Trump and $2.2 trillion for Biden.

STATE OF PLAY: For Trump, the biggest non-COVID drivers of higher public debt were his signature tax cuts enacted in 2017 (causing $1.9 trillion in additional borrowing) and bipartisan spending packages (which added $2.1 trillion).

• For Biden, major non-COVID factors include 2022 and 2023 spending bills ($1.4 trillion), student debt relief ($620 billion), and legislation to support health care for veterans ($520 billion).

• Biden deficits have also swelled, according to CRFB's analysis, due to executive actions that changed the way food stamp benefits are calculated, expanding Medicaid benefits, and other changes that total $548 billion.

BETWEEN THE LINES: Deficit politics may return to the forefront of U.S. policy debates next year.

• Much of Trump's tax law is set to expire at the end of 2025, and the CBO has estimated that fully extending it would increase deficits by $4.6 trillion over the next decade.

• High interest rates make the taxpayer burden of both existing and new debt higher than it was during the era of near-zero interest rates.

• And the Social Security trust fund is rapidly hurtling toward depletion in 2033, which would trigger huge cuts in the retirement benefits absent Congressional action.

WHAT THEY'RE SAYING: "The next president will face huge fiscal challenges," CRFB president Maya MacGuineas tells Axios.

• "Yet both candidates have track records of approving trillions in new borrowing even setting aside the justified borrowing for COVID, and neither has proposed a comprehensive and credible plan to get the debt under control," she said.

• "No president is fully responsible for the fiscal challenges that come along, but they need to use the bully pulpit to set the stage for making some hard choices," MacGuineas said.

[eldritchamy]

He is hidden in the howling void. He is hidden within the tempest. He has braved the storm And the darkness And the pain. And He whispered to the vessel. All this time He whispered And delighted And seduced, And the vessel did obey, For none shall be more mighty And none shall be more wise Than the King Himself.

And the Lord of Time Was blind And vain And knew nothing.

There is the Toymaker, the God of Games. There is Trickster, the God of Traps. There is Maestro, the God of Music. There is Reprobate, the God of Spite. There is the Mara, the God of Beasts. And the Threefold Deity Of Malice, and Mischief, and Misery. There are Gods of Skin and Shame and Secrets. There is Incensor, the God of Disaster, And Her children called Doubt and Dread.

And standing on high Is the Mother And Father And Other of them all: For the God of all Gods Has returned. And His names are many.

His name has been Set And Seth And Sithifer. And His One True Name Forevermore Is Sutekh.

Sutekh is the God of Death And by His hand All creation shall fall Into dust And ashes And ruin.

[munchboxart]

It's midnight so I'm gonna ramble again but about animation/cartoons as a whole included with my lack of knowledge about the industry

A few weeks ago, I remember watching some video about Cartoon Network or something and the guy doing the essay mentioned something like "With the rise of streaming and online as a whole, there is a loss of connection with parents and their kids because back then, you could watch the same cartoon with your kids and recognize who that is". They absolutely did not say those exact words but something along the lines of it, and it's stuck to me for days because it's true! Like I don't think kids nowadays have that kind of connection other than theatrical kids movies, which sucks I think moments like these are precious to have.

Another thing is that I think people kind of underestimate how popular cartoon/2d/3d shows are with adults? Especially young adults because the people who grew up with like, 1990s-2010s shows are probably mostly grown adults now. Probably the best recent example of this is Adventure time and how (I think) big Fionna and Cake is. Like I could go on Twitter and be spoiled hell and back on the newest episodes LOL. How about Owl House and Infinity Train? Bluuey too?? I don't know, but with the writers strike and how swept under the rug animation is, especially on streaming, it just kind of sucks where the current state of animation is right now for everyone as a whole

[zenjestrr]

I've been on an Elder Scrolls binge lately, I'm literally doing like 9 concurrent playthroughs across 6 games and idk what kind of virus I got where I'm this adhd/autistic about a series that won't get a sequel for another decade (and will likely be mid as hell if Starfield is anything to go by)

[lovelywayniac]

Hey any chance people would be interested in commissions?

Just most of the oc requests have been scenes, when I was asking for characters for practice.😅

[fyeahgothicromance]

What people are are saying happened at today's UAP/UFO Congressional hearing: ALIENS ARE REAL AND WE'VE GOT 'EM

What actually happened at today's UAP/UFO Congressional hearing: A former intelligence official, under oath, stated that he has interviewed people who have claimed to work on secret UFO recovery programs.

Also, he turned in evidence that was already declassified and signed off by the Pentagon.

And he was joined by 2 Navy pilots who, also while under oath, gave testimony to their experiences with UAP. One of the pilots was David Fravor who witnessed the famous "tic tac" ufo.

[anachronistic-falsehood]

goodmorning whiskey!!!!!!!!!! um. here is some more parahumans stuff for u........ i'm not. including any of the specific power classifications stuff bc there r PAGES of like. tinker ideas. tinker subclasses. ways to write interesting tinkers. common types of powers. ways to generate tinker powers. etc. for pretty much every category on here. that would be insane to send u. there aren't any Major spoilers in the docs afaik. but the ones that are there r like. big end-of-novel payoff. so. if u want i can send those over!! otherwise. idk. if theres anything that strikes u for the greats (auugh. going 2 be so normal over them btw have i mentioned this??) or just in general power wise. or honestly other worldbuilding there's so much. yeah. lmk & i'll scrounge around for u? ur worm sourcer............. anyway CATKISS.GIF hope ur having a good mornign!!!! sharing my matcha with u <333333

RUBS MY GAY LITTLE HANDS TOGETHER LIKE A FLY. OUHGHHHGH I HAVE IDEAS FOR THE GREATS ALREADY. OUUWHHHHH THANK U ROS THANK U IM GOING 2 BE THINKING ABOUT THEM ALL DAY!!!!! how many classifications do parahumans typically have??? how many is too many??? bc i have three different ideas for strider but idk if i wanna just pile them all on him at once yk?? i know some of them have two classifications w different powers but would three different powers be too much??? the thoughts are thunking rn......

[tj-crochets]

Hey y'all, possibly one of those questions with a ridiculously obvious answer, but can iron-deficiency anemia make you super tired? And if so, how do you fix that? (I got blood test results back but haven't talked to my doctor yet. He'll probably put me on iron supplements or something but I am so tired right now)

[katyspersonal]

[stuck-in-the-ghost-zone]

preemptively sorry for how fucking long this is it is YOUR FAULTT THOUGH!!!! large bowl of seeds for u. it is almost 2am sorry.

SO. there are. two ways to assign the prime defenders powers etc. the first way is just, like, categorize their existing powersets within the prt framework, & the second is to give them entirely new abilities based on the way worm works. delightfully, all the powers they Do have work really well for the most part, so even that doesn't require a ton of shuffling.

categorizing their pre-existing powers:

wiwi-- breaker w/ a shaker subclass. neither of them rated very high, but that's already a rare and versatile enough combination!!

dakota-- brute babeeeey!!! brute/mover its so straightforward. hell yeah babey. i don't know what he'll end up looking like post-heart removal & stuff but my guess is that'll end up looking more like a mover/striker.

vyncent-- now THIS one gave me trouble. i... hm. to say this without talking about stuff that i don't think has come up much already, (hey!! you're at that clockblocker pov! directly related to what flechette says!) i'd call him a grab-bag cape, irt the greats at least. post-greats-- again, i don't know what his powerset will look like after this arc! but if he's going all in w/ the fire magic, that would for sure be some striker shit! :]]]

giving them new powers... man i'm reining myself in so hard from five more paragraphs on Why exactly i'm saying all this.

wiwi still breaker for sure, maybe breaker-master, maybe master-stranger. yknow. powers are fluid, the prt categories are pretty rigid. i... don't know. enough about his situation yet to be clearer than that vague idea yet-- i really like the idea of him just. ditching his body & using a noncorporeal form but he still has to keep an eye on his body i think that's great. the noncorporeal form would b able to change its visibility but still b limited by proximity to the body. & fluctuating energy shit powered by fluctuating amounts of recent-death in the area, maybe probably also limited in that it's only accessible in his breaker form.... also i think u will appreciate this style note from the [UNNAMED PARAHUMANS TTRPG] i'm referencing a lot here.

dakota--in this situation he probably would not. have that mechanical heart and shit. he' would still be a mover/thinker-- thinker rating is for faster mental processing + senses imminent pain for the people in his immediate vicinity. not danger, just pain; it immediately registers ambiently & can be generally traced back to whoever it is. no he can't turn it off ever, it manifests as feeling a similar level of pain, yes it works on himself. + mover-- he can fucking fly. no super strength, just very fast flight & the general "won't splat himself flying into something" capabilities, which meshes well w/ the faster processing & reflexes. i'm split on how exactly this would work mechanically but i will NOT go into that now. i am also not going into the 15k discussion in my brain on why dakota 'notoriously bad at thinking about things' cole would be a thinker but u gotta trust the process ok??

vyncent-- trump!!!! somehow this is the only straightforward one to me? he can copy powers at the full strength or ability level of the original for an unspecified amount of time that's usually 1-30 minutes by touching the cape. crucially, he doesn't have any edge on how to use these powers + can easily misuse or become extremely overwhelmed by them. he's easily the most powerful out of the three of them <33

ashe-- ashe is NOT HERE currently and also it's 1:30 am so i gotta go fucking sleep soon BUT they would be a master. easy. :o) they can make some lil guys n do stuff with them!!!!

in general these are pretty fucking cracked abilities, all of them would b oosely above a seven or so in a number rating once they're really settled in their powers-- this is mostly because i'm assuming that they would still be heirs-apparent to the prime force equivalent, which would b the triumvirate :]] anyway. good lord. this is like the cliff notes edition of what i've been thinking and scribbling in the notes app for the past several hours. sorry if it's fucking incomprehensible. gn!!! <333

AAAAAH FUCK YESSSSSS OKAY OKAY OKAY my response is probably going to be equally as long. so it's fine. oooouh buddy.

I KNOW WHAT BREAKER MEANS NOW !!! I dontttt think ive learned shaker yet. breaker is like.... breaking the laws of physics/shifting planes or whatever. PERFECT for william hell yes. for putting them actually in worm world ... ughhhh breaker/master william is REALLY cool. I havwnt learned stranger yet but i think he would develop a complex over being classified as stranger <3 (like how weld doesn't like that he's classified as a brute even though that's not exactly what it means, he just doesn't like the word) . GODDDD just thinking abt putting pd boys in worm is fucking me up haven't they been through enough. I want to see them all in a fit of despair. william ditching his body is SO good I miss when he would do that, also the powers being limited by how far away he is AND THE AMOUNT OF RECENT DEATH IN THE AREA. holy shit. that's so fucking good . im sure he would not overthink at all the fact that he is stronger when more people around him have died . I'm sure he'd do awesome in the leviathan fight for sure for sure .

DAKOTA BRUTE <3 DAKOTA BRUTE/MOVER I LOVE THIS A LOTTTTTT hellbyes. awesome. it's so perfect for him <3 worm world I'm SURPRISED u didn't stick with brute for him. eyes emoji. I trust your judgement but now i am Thinking... Hmm..... YOU BRING INTO QUESTION something I have been thinking about. and I'm going to probably get derailed a little here but stay with me. how the way powers manifest directly relate to the trigger event. because for a WHILE before we learned taylors I was like "OH i bet the powers are going to be directly related to what traumatic thing happened to them" and then we learn about taylor and grue and a couple more and I kind of lost that theory because while you can. technically draw relations between their powers and their events it seemed like too much of a stretch to do . HOWEVER now my thinking has changed AGAIN and I think the powers ARE related to specific trigger events but it's not as straightforward as "oh something scary happened to you with bugs so now you have bug powers" I think it's gonna be more complicated than that. WHICH. THE WAY THIS RELATES. BACK ON TOPIC NOW. to DAKOTA . assuming his trigger event is still he and katori falling off the building I think it's AWESOME that his powers would manifest as FLIGHT for one. and the fucking. pain sense thing. fuck me up. dakota extreme hero complex cole would be so fucked up by a power where he ambiently senses pain from the people around him at all times and cannot turn it off. I'm sure he would feel so normal about being around william chronic pain wisp 24/7. also I can SO CLEARLY imagine how this power specifically would lead to him getting super overwhelmed in chaotic situations like he does in canon. and just fucking. bolt out of there because it's too much. again. he'd have such a wonderful time in the leviathan fight

I AM AT CLOCKBLOCKER POV !!!! actually technically I'm on kid win pov now but I haven't finished his chapter yet. vyncent grab bag cape..... yeah... I think it would be EXTREMELY funny imagining the PRT in pd world trying 2 classify vyncent like. what the fuck does this kid do . what do we do with him. hes got other guys in his head that give him powers. is he a master??? no he can't fucking control them. is he a striker??? only SOMETIMES. is he a blaster?? AGAIN ONLY SOMETIMES. cannot classify him bitch!!!!!!!! giving him worm powers though.. UGH. being able to touch someone and COMPLETELY copy their powers but only for a short period of time???? I fucking love that a lot. he WOULD be the most powerful out of them!!! I can hear taylors inner analysis dialogue about him now and it's very similar to the clockblocker "DONT LET HIM.TOUCH YOU" panic. loooove imagining this playing off of the rest of pd,,, i know there was AT LEAST one time where he had william sort of transfer some of his ghost powers for a minute? I think it was during the lich fight in the theatre but i just remember vycnent floating and going intangible and NOT KNOWING how to control it or anything. loveeee that. in world dynamics I feel like vyncent would be a late addition to their team (instead of coming from another world maybe he just. had his trigger event happen way later than the other two..or something.) and not trusting them as much at first/being REALLY shaky using either of their powers but after a while being really comfortable in a fight with using either Williams or dakotas powers in a fight. Just like. imagining the fluidity of how they'd work together in a tense situation assuming they're not being complete dumbasses <3333 UGH it's really good

AAAASHE ASHE ASHE IM SOOO SO GLAD YOU INCLUDED ASHE IN THIS I miss him.so much every day. from what I know so far master involves having/making/controlling some sort of minion (cannot think of a better word than that rn) AND I THINK THATS REALLYYYY perfect for ashe. i assume he would actually work pretty closely to canon in that his limitation would be the book? or if he doesn't have the book maybe his limitation would be a) having only a few different types of things he could summon (the big hand, the water fairy, duck etc) and/or b) only being able to control them.for a short amount of time after they're summoned so he has to be quick about dismissing them. can't keep the demon hand around for too long or it might start picking things up and throwing them at random. putting teammates in danger bc he can't control it anymore etc etc. alsooooooo in clockblocker pov they VERY briefly mentioned the possibility of having secondary trigger events (?!!!!?!?!) and you know I locked onto that SO FUCKING HARD. ashe being born with powers and then his secondary trigger event being his mom's death <3 im.NOT even going to attempt to talk about how the trickster would work in worm world/if it would even exist in this setting bc i don't know enough about the types of powers and things yet..but just know. I am keeping this in the back of my mind "this is a fun surprise tool that will help us later" style

[retconomics]

the absolute rabbit hole that is looking into the COL/housing/wage crisis in the US...

[mariocki]

Parasite (1982)

"That thing on your stomach..."

"A new strain of parasite. I deserve it, in a way. I created it."

"For the Merchants? Why?"

"I thought for the government. They're so mixed up with the Merchants now, they work for one another. This 'thing', as you call it, is growing. It's dormant now but it will soon grow larger... and kill me."

[sk3l3t0n444]

how are people scared of bats :(