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catboybiologist · 8 months ago

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“As a biologist, the terms biological woman and man don’t make any sense to me” okay then you’re an idiot and a terrible biologist. I swear to god, morons like you only become biologists just so you can hold it over others, when in reality, if biology deniers like you can become biologists, then being one really doesn’t mean much anyway. But this probably just gave an autogynophile like you a boner to read, anyway.

Oh fun! Haven't gotten one of these in a while. Disregarding the fact that you somehow think the qualification for being a biologist entirely hinges on defining womanhood, I do need to ask some clarification. I know I'm feeding the trolls here, but here we go: does your definition of "biological woman" mean:

Sociological woman? Eh, context dependent, I'm not fully out of the closet, but oftentimes, I am and present femme. So let's call that one 50/50.

Psychological woman? Because I am one.

Neurological woman? Because I am one [1].

Physical woman? My soft tissue redistribution is handling that well.

Hormonal woman? My blood tests are within cis female ranges.

Transcriptional woman? As a signalling molecule, the downstream effects of estrogen have broad transcriptional effects, completely changing the profile of gene expression and functional genomics of my cells. [2]

Genetic woman? I mean, see my above point- as far as my genes that are actually active, I have all of the same transcripts being produced, controlling which genes are expressed.

Karyotypic woman? I actually have a few signs pre-HRT that might point to a non-XY chromosome pair, but I haven't had a karyotype. We'll put that down as unknown. And hell, even if its XY, there's plenty of cis women who are karyotypically XY, with suppressed sry or complete androgen insensitivity. Interestingly enough, a completely androgen insesitive woman can go her whole life without knowing- and functionally, is very similar to a trans woman, actually. Fancy that. [3]

Reproductive woman? I can't produce an egg cell, but neither can significant fractions of cis women. Also, this is all gonna change soon, which is fun. [4]

There's also a lot of understudied aspects to the biology of HRT and even pre-HRT that are emerging, largely demonstrating widespread cellular and genetic remodeling of trans individuals undergoing hormone therapy. The field is a bit behind due to constant political pressure to revoke funding, but a lot of the results are extremely exciting in both testosterone and estrogen hormone therapies. I'm sure that, as a self professed biology As someone who presumably has a lot of expertise in biology, I'm assuming that you're aware of all of this cutting edge research, and are keeping up with modern papers, including but not limited to these cool findings:

Trans men on HRT exhibit significant genetic and transcriptional changes that make them biochemically male. [5][6]. It's a good hypothesis that the same happens with estrogen treatment, but those studies don't exist yet- I'm sure you're reserving judgment until more publications exist, of course.

Trans men on HRT develop male cell types and tissues. [7]

Trans women experience muscular and blood cell changes that align with cis women moreso than cis men [8]

And many, many more! This is an exciting, underserved, and groundbreaking field of research, and I'm sure you're keeping up with the latest in scientific journals about it.

I'm sure, of course, that you understand that it becomes impossible to draw a distinct line anywhere in here, and that words like "woman" are shorthand for the myriad of traits that invisibly synthesize in our mind and in society to represent a concept? I'm sure you understand that science is fundamentally descriptive, not prescriptive? I'm sure that you understand that these findings, while really cool and interesting, actually don't mean jack shit about what the word "woman" means or not?

As someone who is the ultimate decider in what a biologist is, I'm sure you know that bioessentiallism is a childish mindset that completely ignores and disregards the constantly changing, dynamic nature of biological systems, something that extends well beyond biological sex and its relation to gender.

I'm sure that also, that you understand that beyond just this, that the role of science in society is to advise how to achieve our moral principles, not create moral principles in themselves. And I'm sure that understanding means you know that trans affirming healthcare and supportive societal treatment leads to reduced mortality and increased happiness for everyone, right?

So great to talk to someone who is surely a scientist on this. You are a biologist, if you're talking like this, I assume? I assume you're not going to spit complete misreadings of scientific language from the background sections of these papers that only reveal you've never read a scientific paper in your life if you're thinking this way? I assume you have experience interpreting data like this?

Also, imagining my genitalia while writing this? Ew. Please stop projecting your fetishes into my inbox.

Works cited:

Kurth F, Gaser C, Sánchez FJ, Luders E. Brain Sex in Transgender Women Is Shifted towards Gender Identity. J Clin Med. 2022 Mar 13;11(6):1582. doi: 10.3390/jcm11061582. PMID: 35329908; PMCID: PMC8955456.

Fuentes N, Silveyra P. Estrogen receptor signaling mechanisms. Adv Protein Chem Struct Biol. 2019;116:135-170. doi: 10.1016/bs.apcsb.2019.01.001. Epub 2019 Feb 4. PMID: 31036290; PMCID: PMC6533072.

Gottlieb B, Trifiro MA. Androgen Insensitivity Syndrome. 1999 Mar 24 [Updated 2017 May 11]. In: Adam MP, Feldman J, Mirzaa GM, et al., editors. GeneReviews® [Internet]. Seattle (WA): University of Washington, Seattle; 1993-2024. Available from: https://www.ncbi.nlm.nih.gov/books/NBK1429/

Murakami, K., Hamazaki, N., Hamada, N. et al. Generation of functional oocytes from male mice in vitro. Nature 615, 900–906 (2023). https://doi.org/10.1038/s41586-023-05834-x

Pallotti F, Senofonte G, Konstantinidou F, Di Chiano S, Faja F, Rizzo F, Cargnelutti F, Krausz C, Paoli D, Lenzi A, Stuppia L, Gatta V, Lombardo F. Epigenetic Effects of Gender-Affirming Hormone Treatment: A Pilot Study of the ESR2 Promoter's Methylation in AFAB People. Biomedicines. 2022 Feb 16;10(2):459. doi: 10.3390/biomedicines10020459. PMID: 35203670; PMCID: PMC8962414.

Florian Raths, Mehran Karimzadeh, Nathan Ing, Andrew Martinez, Yoona Yang, Ying Qu, Tian-Yu Lee, Brianna Mulligan, Suzanne Devkota, Wayne T. Tilley, Theresa E. Hickey, Bo Wang, Armando E. Giuliano, Shikha Bose, Hani Goodarzi, Edward C. Ray, Xiaojiang Cui, Simon R.V. Knott, The molecular consequences of androgen activity in the human breast, Cell Genomics, Volume 3, Issue 3, 2023, 100272, ISSN 2666-979X, https://doi.org/10.1016/j.xgen.2023.100272. (https://www.sciencedirect.com/science/article/pii/S2666979X23000320)

Xu R, Diamond DA, Borer JG, Estrada C, Yu R, Anderson WJ, Vargas SO. Prostatic metaplasia of the vagina in transmasculine individuals. World J Urol. 2022 Mar;40(3):849-855. doi: 10.1007/s00345-021-03907-y. Epub 2022 Jan 16. PMID: 35034167.

Harper J, O'Donnell E, Sorouri Khorashad B, McDermott H, Witcomb GL. How does hormone transition in transgender women change body composition, muscle strength and haemoglobin? Systematic review with a focus on the implications for sport participation. Br J Sports Med. 2021 Aug;55(15):865-872. doi: 10.1136/bjsports-2020-103106. Epub 2021 Mar 1. PMID: 33648944; PMCID: PMC8311086.

#cw transphobia #biology #basic biology

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largedogcollar · 1 year ago

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Someday / 海太郎

All by 海太郎

[Lyrics]

いつか彼方まで飛べる気がして

今明日に手を伸ばした

なんて美しい日

昨日までの嵐は過ぎ

散る花は惜しむように

ただ頬を撫でていく

憎み合ったことなんて

忘れてしまおう

僕はもう一人でゆくよ

いつか天高く翔べる気がして

今大地蹴って走り出す

いつも溢れ輝ける想いの丈

さあ全てを新しく

生まれ変わらせてゆけ

勘違いさせておいてよ

#original music #original song #music #song #japanese #japan #japanese pop #indie pop #synthesizer v #female vocal

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gardening--tools · 4 months ago

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me while playing fo4 because i’m an opinionated bitch and i disagree with bethesda’s character design

anyway. presenting,

a detailed look at every companion’s appearance, according to me.

(these are all headcanons. they might not be yours, but they are mine. i wrote this as a fic-writing reference, but i don't mind sharing so long as we're all nice about it. also, spoilers ahead for companion quests, both in vanilla game and dlcs. you've been warned okay love you have fun. sorry in advance that you can clearly tell who my favorite character is.)

cw: heights represented by the united states customary system. sorry metric users :/

Ada. Modified RobCo Assaultron. 2074 model. SN has been sanded off and replaced with "ADA", painted carefully (lovingly) in blue script. It's clear that it has been reapplied multiple times, as many times as necessary. Post-Mechanist quest, she requests to have the names of her fallen friends painted on her body as well.

Cait. Pre-addiction recovery, scrawny-strong. Blood, muscle, bone and not much else. Very short. Like, south-side of 5'3". Has a very rectangular body shape. Hard angles. Was bright strawberry blonde when she was a kid, but it got darker as she got older. Hazel eyes. Freckles year-round and all over. She doesn't burn super easily, but she doesn't really tan either. Just freckles. Nose is crooked from being broken too many times. Post-addiction recovery she is a beef. cake. With Sole's help and resources she gains plenty of weight post recovery. Other than the normal weight gain that comes after recovering from addiction, she finds she enjoys exercise—especially weight lifting—and that it helps her manage her cravings. Her biceps are unfair. If I can be honest, I really only shared this so I can start proselytizing for my Fat Cait Agenda.

Codsworth. Standard GAI Mister Handy. 2076 Model. SN: 01HND-7619-0163. This is only visible because the 2076 Handys had their SN's embossed. All other markings that were printed or painted on have eroded away. A cute fact about Codsworth is that, despite his 200 years of wear and tear, he doesn't have a single dent on his exterior panels. Not. A. Dent. Scratches, yes. Scuffs, sure. No dents. He takes his structural integrity very seriously, thank you. He will brag about this if you let him.

Curie. Pre-companion quest, Modified GAI Miss Nanny. 2072 Model. SN has been scratched off and replaced with what is probably "CURIE", but the combination of chicken scratch writing and 200 year old marker makes it illegible. Post-personal quest, Generic Female Synth Body. Average body weight, brown hair, brown eyes. (I know she technically has "Hazel Blue" eyes but I disagree. It's my post and I get to make the rules here.) Her only deviation from "average" is her height. Generic Synth Height is 5'10", for both male and female synths. Takes time to look neat—neatly trimmed nails, trimmed hair, etc—and enjoys it.

Danse. M7-97 was a vanity design* so Danse looks a little different from the Generic Synth design. Still has the brown hair, brown eyes, but is a touch shorter than the standard. 5'8". Latino or Hispanic. His hair is insanely thick, but his beard always grows in a little patchy and with the odd blond patch just below his right ear. (This was not an intentional part of his “design.” Genetics, even synthesized genetics, get funky sometimes.) Carries weight like a strongman weightlifter. Thicker than average, even for the Brotherhood, so he's always had to have his flight suits and PA specially altered. (Thicker than average in regards to BODY TYPE you sickos– This is not that kind of post lmao.)

(This post from slocumjoe is a huge influence for my headcanon for Danse! Thank you for going through your archive to find it!)

Deacon. The Average Guy Ever™. Average height, average build. I'm firmly in the "Deacon is a Good Spy, actually" camp, so. Uncanny ability to adjust how he looks just by altering his posture. His weight has always easily fluctuated, so he can go from stick thin to bulked up in a matter of weeks. No matter how many surgeries he gets, he cannot hide the freckles. They always come back. He would have had piano hands if he hadn't been a chronic brawler in his youth. Knuckles are very crooked now. Eyes so blue they're nearly grey. Ginger. Has long eyelashes that are frankly illegal for someone who covers his eyes all the time.

Dogmeat. Dog. He has six toes on his back left foot.

Gage. 5'11". In an alternate universe, would tell people he was 5'9" just to fuck with them. Was a towheaded kid whose hair darkened significantly as he grew up. If he spends a lot of time out in the sun, though, it will turn a sandy blonde/light brown. He keeps his hair short because otherwise it gets very curly and floppy and it really kills his "bad-guy raider" vibe. Would be one of those white boys who tans super well but also thinks wearing sunscreen is for the weak. Scarred to shit. Holds onto muscle for a really long time. Underbite. Slutty little waist because I think that's funny.

Hancock. John Prime was already pretty wiry to begin with, and becoming a ghoul has only emphasized this. 5'7" but seems shorter because he's always leaning on something. Draping, even. He's like if a man was also a liquid, somehow. His remaining hair is incredibly thin, but is the most vibrant golden blonde anyone has ever seen. Eyes are dark due to discoloration, but sometimes—if he's taken in a ton of rads—the edges of his irises will glow subtly. Several piercings on his ears, but he used to have more. Lost them on account of his nose falling off. (You know how it is.) Replaced them with an astonishing collection of rings. Cheekbones that could slice a brahmin. Missing his fourth toe on his right foot.

MacCready. Definition of scrunkly. Not a lick of fat anywhere to be found. 5'5". Has a Gunner tattoo on the left side of his forehead and he hates it. It's why he wears his hat so low. Had an ear pierced once, but it got ripped out ages ago. His left earlobe is split now. He very clearly needed braces growing up but obviously didn't have access to that. Bottom teeth are crooked. His cuticles are picked to shit. Sandy brown hair. Cuts his own hair, but only cares about the hair around his face. Line of sight. Sniper. You get it. Is generally too lazy/uninterested in the rest, and will neglect it until it gets too long, so. Mullet (hot).

Nick. See, the problem with my synth grandpa is that this is the only character whose design Bethesda completely and utterly nailed. Like yeah, he does look like that. You got it. You did it. Perfect, no notes. Like all other Generic Synths, he's 5'10".

Old Longfellow. Exactly what you would expect an Old Hermit-Mariner Driven To Eldritch Madness By The Fog and The Sea would look like. The wildest eyebrows anybody has ever seen. Like you could take a comb through those bad boys. His hair is past his shoulders and fades into his beard. Stark white hair due to the stress of living alone on an island and from What He's Seen. You cannot convince me that there are not some Lovecraftian nasties living in the sea. They Know Longfellow, but Longfellow Knows Them. 6' until he stands up straight and then he's like. 6'5". Liver spots across his face and hands. Looks like he has cataracts in both eyes, but somehow can see better than you.

Piper. By far the companion whose Bethesda!verse appearance I disregard the most. In my heart she is a South Asian woman. On the taller side, between 5'8" and 5'9". Super thick, dark brown hair that in fact does just Look Like That (unfair). Her hair grows from fairly far down on her neck. Deep brown eyes. Spends lots of time on her makeup, even when she's out in the 'wealth chasing leads. Prefers red lips and dark liner close to her lid-lines. Her cupid's bow is super pronounced and she does her makeup to highlight it. On the softer side in regards to physique. Has a burn scar on her right forearm from a cooking mishap back when she was still trying to figure out how to live on her own and take care of Nat at the same time. Bites her nails.

Preston. Personification of someone telling you that everything is going to be all right. Tall, 6'. Pretty standard physique for someone who grew up on a farm and then became a soldier in a wasteland militia. Very square hands. Lets his hair grow out a little bit because he (forgets about it) likes it. Brown eyes that look like honey when the sun hits them. Other than the two scars on his face—one running down his left cheek, the other a small nick on his top lip—he has a scar from a bullet wound on his right shoulder. Has a stick and poke tattoo of the Minuteman coat of arms on his left arm, just where his shoulder meets his bicep. Top lip is bigger than his bottom lip. Dimples when he smiles. Huge smile, smiles with his whole mouth. Legs like an adonis. Someone get this man into some 4' inseam shorts, STAT.

Strong. Super mutant. He was a Butcher, so he's a little beefier than your average mutant. Of course, this is only known to other mutants, as the subtleties of mutant physiology tend to be lost on non-mutated humans.

X6-88. Generic Courser Build. While Generic Synths are designed to blend in with the everyman, Generic Coursers are designed to inspire fear in every man. (booo bad joke tomato tomato) 6'3" but stands so perfectly straight that he seems taller. Has the superhero build, but like naturally. Keeps his hair in a short fade. Bottom lip is lighter than the top lip. Has little lines around his mouth from all his frowning. Has one (1) singular scar on his chin. He won't tell you where he got it (it's from him eating it on concrete steps. That was the one mission he asked for an extension on, so the evidence of him beefing it would heal.) Also chronically wears sunglasses. Behind those aviators are grey eyes that are so pale and sharp, they almost look white.

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ms-hells-bells · 6 months ago

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your daily reminder and easy source for debunking mras and genderists.

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nineslugs · 10 months ago

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Some basic anatomy notes on kee, one of the sophonts in Sea of Spires. They are the most common sophont in the Keeland biotope and, after the establishment of kee-gardens in the Terran biotope hundreds of years after first contact, are the most common Keeland sophont outside of their biotope.

Kee bodies are divided into six segments, each with a single limb and spiracle, arranged in an alternating pattern around their central nerve cord. This lends their bodies a slight asymmetry. Their first segment is most derived, with the limb adapted into a jaw and the spiracle adapted into a "vox" organ capable of synthesizing a wide range of sounds. In a typical kee the fore vox is only present on the right side and a second smaller vox sits on the left side of their terminal segment. In both the front limb and wing segments the spiracle remains intact as a breathing organ.

Also pictured is cranial differences between N and T-type kee, and genitalia differences between males and females. Both sexes have brightly colored flanges surrounding their cloaca for display, similar to the display flanges on their face. The main external difference is that males have brighter flanges and a pair of claspers flanking the cloaca.

N (nurturing) and T (territorial) type kee have no genital differences, but posess major morphological differences in the rest of the body. T-types have very brightly colored heads and wings, along with larger wing-claws and a more prominent beak spike. They are more aggressive and prone to wander, tending towards protecting the edges of a kee flock's territory and participating in foraging activities. N-types tend to fill more of a homemaker roll, raising and guarding young and maintaining their nests.

#my art #worldbuilding #speculative biology #sea of spires #sophont #keeland biotope #kee

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warismenstrualenvy · 10 months ago

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A dead body touched with the Odour of Sanctity can’t just smell ok. It has to possess the mysterious presence of a supernaturally pleasant odour. The scents can be brief or persistent, attached to the body, grave, water the body was bathed in, or objects the person touched. In the case of St. Padre Pio, his spectral scent of roses and pipe tobacco visited people after his death and was considered a sign of his saintly intercession. All Odours of Sanctities are described as sweet, with notes of honey, butter, roses, violets, frankincense, myrrh, pipe tobacco, jasmine, and lilies being the most frequently reported accompaniments. The scent is also always culturally specific and deeply intertwined with symbolism. (...) One of the most popular of the fragrant saints, St. Therese of Lisieux smelt of lilies, violets and roses upon her deathbed. Her most often attributed quotes is, “The splendour of the rose and the whiteness of the lily do not rob the little violet of its scent…If every tiny flower wanted to be a rose, spring would lose its loveliness”. It also should be noted that during Therese’s lifetime violet absolute was synthesized, making a material that was once the most expensive fragrance component in the world, affordable for all and the de rigueur fragrance of respectable women. To the Victorian palette, violets represented chastity, modesty, and feminine virtue. Lilies and roses also have a long association with Jesus and Mary. Therese’s Odour of Sanctity creates an olfactive tableau of Therese, the respectable modest female, alongside the Virgin Mary and Jesus. Before 1875 however, the scent of violets would not have been readily identifiable to the general population, and no Odour of Sanctity is associated with violets in any primary sources before that time. There is also an active association between Osmogenesia and Stigmata, with the floral odour emanated from the wounds. Stigmatic Osmogenesia in every case is reported as the smell of roses, which again is deeply symbolic with the wounds of Christ. While there is no way of knowing just how many people the Odour of Sanctity was associated with, in the Late Medieval and Early Modern periods ascetic mystics make up a large population of those afflicted with this post-mortem perfume. In particularly female mystics that lived cloistered lives. These women’s bodies suffered through harsh asceticism and self-inflicted mortification. Yet through the isolation, hardship, poverty, and virginity, these mystics sought to control their bodies and transform them into sacred vessels. It, therefore, makes sense from their perspective that, if successful, the discarded vessels of these perfected souls should already be touched by a whiff of Paradise. The association of the Odour of Sanctity with cloistered women parallels the profane eroticism of the earthly woman with the chaste eroticism of the sacred woman; while the worldly woman’s corpse corrupts by its nature and stinks, so the heavenly woman’s body remains pure and fragrant. However, the conversation is still about a woman’s body.

Nuri McBride, The Odour of Sanctity: When the Dead Smell Divine

#perfume #christianity #quote

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icedbeverageenjoyer · 5 months ago

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(📺🖤📺🖤📺🖤📺🖤📺🖤📺🖤📺🖤📺🖤)

Mr. Puzzles has manufactured everything about himself, including his voice: (A long post!! 📺)

A thing I've noticed is just how often his voice changes, most notably when he's switching from his deeper narrator voice to his more energetic showman voice in the promo trailer. ^^^

Here's another example from the song. Both lines are said in two distinct voices, none of them being the usual one we hear from him. One has a more pronounced Transatlantic accent and the other has an American one. We can assume someone else is talking and he just overlays himself on top, but he is explicitly the one shown to speak in that moment. ^^^

This next one might be a stretch, but I think the supporting female vocals could be him as well. It is heavily implied he works alone and doesn't trust others with his vision so it kinda makes sense that he would also sing the song on his own. (If that's true damn does he have a good voice) ^^^

Even the critical podcast host could be him. The first voice is deeper and rougher while the second is more sly and has a distinct influxion that is unique to Puzzles, so they could be just his inner thoughts and insecurities audibly manifesting through some complicated technical means.

He is alone in his office, staring at all the monitors that display his hard work. And he is not satisfied. His mind begins to wander and his self doubt begins to manifest out loud in the form of others criticizing him, further fueling his crippling perfectionism. ^^^

Also here, when his lifelong dream is finally met he can't contain his (ever so slightly malicious) glee, and his voice deepens and begins to glitch out. ^^^

Also a bit unrelated but did y'all notice that when he says 'crying' he is shown with his crazy big smile? You know, his main expression on all the promotional material.

Conclusion?

I think his upbeat showman voice isn't how he usually sounds, but what he thinks others would like him to sound like. He has to keep up the energy that the audience has come to expect of him so he manufactured the perfect tv host voice to keep as many tuned in as possible.

I headcanon his real voice to be deeper, raspier and very monotone. I think that while he was smoking he had to turn off his voice synthesizer so the smoke won't damage it, which is why he doesn't talk in the scene. He has lost every bit of himself by molding into what he thinks people would like, and any reminder that he was once someone else makes him uncomfortable.

I'm going insane chat.

#mr puzzles smg4 #smg4 mr puzzles #smg4 puzzlevision #smg4 fanart #smg4 #mr puzzles #mr. puzzles #puzzlevision fanart #puzzlevision #puzzlevision movie #puzzlevision arc #fanart #headcanons

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