#ctsc

[covid-safer-hotties]

Also preserved in our archive

A new Cleveland Clinic-led study published in The EMBO Journal shows that mild and asymptomatic SARS-CoV-2 infections can trigger immune responses in a pregnant individual that may cause serious inflammatory responses in the developing fetus. The study's findings also suggest that vertical transmission of the virus from a pregnant individual to the fetus is more common than previously estimated; and that even without this transmission, a pregnant individual's immunological response to infection may impact the fetus.

Typically, healthcare providers test for SARS-CoV-2 infection, the virus that causes COVID-19, in a newborn through a nasal swab after birth. For this study, Cleveland Clinic researchers collected samples from the placenta and the fetal compartment (tissues that surround a fetus while still in utero), and then analyzed them for the presence of inflammatory markers and virus. They found higher instances of the virus in those tissues than what could be found in a traditional nasal swab, and even in the absence of a full infection they found small proteins from the virus had passed through the placenta. The researchers hope their study will help ensure pregnant individuals can rapidly and reliably receive evidence-based medical care needed during novel outbreaks and public health crises.

When the COVID-19 pandemic first began, OB/GYN Ruth Farrell, MD, and colleagues at Cleveland Clinic and other major medical centers wanted to determine the best way to prevent and manage the infection in their pregnant patients. Pregnant individuals required different medical considerations during the pandemic compared to their nonpregnant counterparts; Dr. Farrell notes that many of the prevention and treatment approaches used in non-pregnant patients either did not have enough data to use in pregnant patients or were not feasible to perform.

"During the early stages of the pandemic, there were significant delays in determining how best to prevent and treat pregnant patients with SARS-CoV-2 infection," explains Dr. Farrell, who also serves as the Vice Chair of Research for Cleveland Clinic's Obstetrics & Gynecology Institute.

Dr. Farrell worked with clinical colleagues across the Clinical and Translational Science Collaborative (CTSC) of Northern Ohio to develop methods for examining the impact of SARS-CoV-2 infection on pregnant patients, including researchers from University Hospitals of Cleveland and MetroHealth Medical Center.

She then teamed up with Cleveland Clinic maternal-fetal virologists Jolin (Suan Sin) Foo, PhD and Javier (Weiqiang) Chen, PhD from the Infection Biology Program to determine how the virus impacted the immune systems of both mother and child.

When the standard-of-care COVID-19 test is used to detect the virus in newborns (nasal swabs upon birth) they only detect infections in about 2% of children whose mothers tested positive for the virus during pregnancy. However, when Drs. Chen and Foo looked at tissues that surrounded the newborns when they were still in utero-; including the amniotic fluid, chorion and umbilical cord plasma -; they detected high levels of the virus in over a quarter (26%) of study participants.

The team also found elevated immune and inflammatory responses affecting the pregnancies of about 66% of study participants. Dr. Foo had previously shown elevated levels of fetal inflammation in pregnant individuals who experience severe SARS-CoV-2 infections during pregnancy, but few had asked whether asymptomatic or mild infections had the same effect. Now that they have their answer, however, the team were faced with even more questions.

"Even though we only saw vertical transmission of the full virus infection a quarter of the time, we saw strong immune and inflammatory responses in over two thirds of the cases," Dr. Foo says. "It was clear that even when the fetuses were not technically infected, they were still being impacted by their mothers' viral infection. But we weren't quite sure how."

Elevated levels of inflammation during pregnancy, in COVID and other conditions, can have negative impacts on the offspring long after birth. Further research can define how inflammation affects children in the long term.

Dr. Chen noted that the SARS-CoV-2 virus has a protein called ORF8 that physically resembles a human immune protein called immunoglobulin G that passes through the placenta from mother-to-fetus during development. He wondered whether the viral protein could also pass through the placenta's defenses to cause inflammation in the fetal compartment.

Drs. Foo and Chen, alongside co-first authors Tamiris Azamor, PhD and Débora Familiar-Macedo, PhD (a former and current postdoctoral researcher, respectively, in Dr. Foo's lab), were able to prove that the virus-made ORF8 did indeed pass through the placenta into the fetus. ORF8 then bound to immune proteins and "turned on" a process called the complementary immune response.

At normal levels, the complement system is a good thing during pregnancy and helps the fetus develop properly, Dr. Familiar-Macedo explains. At higher levels, the complement system can cause dangerous inflammation in a developing fetus. Lab studies supported that this immune response directly led to the elevated levels of inflammation seen in the fetuses of pregnant patients infected with the SARS CoV-2 virus.

"Our findings challenge the currently accepted definition of vertical transmission, or what it means to transmit an infection from mother-to-fetus," Dr. Chen says. "We have shown that it is indeed possible for only a small part of a virus to slip through and affect a pregnancy."

Dr. Foo adds that she hopes her team's findings will serve as guidance for healthcare practitioners, researchers and policymakers alike on further research into vertical transmission and long-term care.

"We've shown that the misconception that uninfected babies born from infected mothers are fine, is sometimes just that: a misconception," she says. "Pregnancy is such a vulnerable nine-month period where any change from the norm can cause long-term impacts on the baby, so we need to work more closely with these individuals to understand their unique healthcare needs during public health crises. It's the only way to make sure they receive the care they need."

Source: Cleveland Clinic

Journal reference: Azamor, T., et al. (2024). Transplacental SARS-CoV-2 protein ORF8 binds to complement C1q to trigger fetal inflammation. The EMBO Journal. doi.org/10.1038/s44318-024-00260-9. www.embopress.org/doi/full/10.1038/s44318-024-00260-9

[barclayitaly]

Key Benefits and Results In the quest for healthier, shinier, and more manageable hair, keratin conditioner has emerged as a game-changer. Rich in keratin—a key protein that makes up your hair, skin, and nails—this conditioner offers a multitude of benefits that can revitalize and transform your hair. In this blog, we’ll explore the key benefits of keratin conditioner, how it works, and how to use it effectively to achieve stunning results.

Description

BarclayItaly’s Keratin Conditioner is specially designed for all hair types. Enriched with 2% Keratin to strengthen and repair, 2% Argan Oil for deep nourishment, 2% Quinoa Water for hydration, and 2% Bamboo Silica to boost shine and resilience, this conditioner revitalizes your hair from root to tip.

Formulated with 100% natural, alcohol-free, and sulfate-free ingredients, our conditioner is vegan, cruelty-free, and free from harsh chemicals or synthetic fragrances. Herbal and plant-based, it provides the perfect blend of moisture and protection, leaving your hair soft, smooth, and full of bounce.

Say goodbye to breakage and dryness and hello to stronger, healthier, and shinier hair. BarclayItaly’s Keratin Conditioner will help you naturally achieve beautiful, nourished locks.

Ingredients

2% Keratin + 2% bamboo silica + 2% Argon oil + 2% Quinoa water , Aqua, EDTA, CTSC ( conditioning agent), emulsifying wax, mango wax, shea butter, vegetable glycerin, aloe vera extract, ritha extract, heena extract, sodium gluconate (cleansing agent), BHT, almond oil, argan oil, sunflower oil, UCURE (conditioning agent and thickner), perfume/essential oil

Usage Instructions

After shampooing, apply a generous amount of conditioner to wet hair, focusing on the mid-lengths to ends. Leave on for 2-3 minutes, then rinse thoroughly. For best results, use after our Keratin Sham

[itsrattysworld]

Without Prejudice Mervelee Myers Share YouTube Misogyny Of Content Creators Using Our Open Book Lifestyle Re Our Early Intervention Strategies Survival Disabilities Poverty Sharing The Stories We Grew Up With Mr. Barnaby 1st Suicide I Will Be Telling Them In Live Broadcasts How I Use Writing Therapy From My Father Was Stricken With Parkinson's Dr. Joanna Pennack Of Nexus Health Group Boast Of Removing Me From The Practice My Garden Will Honour Husband Arnold Ebenezer Tomlinson Love Nature 23 Years In Bermondsey Met Police Must Address Hate Mob Target Me 10/9/2024

Refer to South London MC Mailbox reply SouthLondonMCSat, 7 Sept, 10:59 (3 days ago)to me Dear Sender,           ———————————————————————————————————————————————————————- IMPORTANT: HMCTS Courts and Tribunals Service Centres (CTSCs) now deal with general enquiries about London Magistrates’ cases.  Please send any future email queries and requests to contactcrime@justice.gov.uk.           …

[abcnumerique]

Séance #13 – S’informer ne devrait pas être se convaincre

Dans le paysage en évolution rapide de l'ère numérique, la façon dont nous nous engageons dans le discours public et participons aux processus démocratiques a subi une profonde transformation. Explorons ces deux concepts qui façonnent notre paysage social contemporain : la faisabilité du débat public en ligne et l'escalade de la polarisation et de la "brutalisation" des échanges en ligne, ainsi que la désinformation en général.

Débat public à l'ère du numérique

 Internet était autrefois annoncé comme un outil qui démocratiserait l'information, favorisant des débats publics ouverts et inclusifs. Cependant, la réalité s'est avérée plus complexe. La facilité de la diffusion d'informations en ligne a conduit à une cacophonie des voix, ce qui rend difficile de distinguer des informations crédibles de la désinformation. Le potentiel de débat public est entravé par des chambres d'écho et des filtres, où les individus ne sont exposés qu'à des informations qui s'alignent sur leurs convictions existantes. En conséquence, l'espace numérique peut contribuer involontairement au silence des diverses perspectives, entravant l'idéal démocratique d'un discours public éclairé et raisonnable.

Les échanges en ligne, autrefois conçus comme des plateformes de dialogue constructif, se sont transformés en arènes d'hostilité et d'agression. Ce phénomène, souvent appelé "brutalisation" du discours, se caractérise par l'utilisation d'un langage inflammatoire et le rejet des nuances. En conséquence, les conversations significatives sont étouffées et le potentiel de trouver un terrain commun diminue, ce qui pose un défi important aux fondements d'une société démocratique saine.

Les bulles informationnelles, la désinformation numérique et la "post-vérité" en démocratie

La montée des bulles informationnelles, alimentée par des algorithmes qui adaptent le contenu aux préférences individuelles, a contribué à la propagation de la désinformation numérique. Dans un régime démocratique, l'intégrité de l'information est essentielle à la prise de décisions éclairées. Toutefois, la prolifération des récits « post-vérité », où les convictions émotionnelles ou personnelles ont plus de pouvoir que les faits objectifs, constitue une menace pour le processus démocratique. Répondre à ce défi exige non seulement des interventions technologiques, mais aussi un engagement collectif en faveur de l'alphabétisation des médias et des compétences en matière de réflexion critique pour naviguer dans le paysage complexe des informations numériques.

Pour en connaître davantage sur cette réalité, voici un lien d'une page web du Gouvernement du Canada qui expose et explique les conséquences qui lui sont liées:

https://www.canada.ca/fr/campagne/desinformation-enligne.html?utm_campaign=csec-ctsc-online-disinformation-23-24&utm_medium=sem&utm_source=ggl&utm_content=ad-text-fr&utm_term=d%C3%A9sinformation&adv=2324-472201&id_campaign=20556416297&id_source=156443934871&id_content=674167645145&gclid=CjwKCAiA1MCrBhAoEiwAC2d64UF5z1Eeu9AkTFIGJM3zIcLpuUPawH5qYWoiHuXKpnAetqETB7vkzBoC7RsQAvD_BwE&gclsrc=aw.ds

[anthonie7]

Séance #9 : La désinformation en ligne, combattre cette menace omniprésente

Internet est un monde "magique" où l'on peut trouver toutes sortes d'informations, mais malheureusement, il est aussi un terrain de jeu pour la désinformation. Cette dernière consiste en la propagation de fausses informations délibérément créées dans le but de tromper les utilisateurs. Nous en sommes conscients, mais nous continuons pourtant à tomber dans le piège en croyant que certaines informations sont véridiques, sans prendre la peine de les vérifier. Il est pourtant essentiel de comprendre comment faire face à la désinformation afin de préserver la qualité de notre compréhension du monde en ligne.

En effet, la désinformation en ligne est un problème qui touche tout le monde, qu’on le veuille ou non. Elle peut prendre de nombreuses formes telles que la propagande ou de simples rumeurs, et se propager à une vitesse extrêmement rapide. Les algorithmes de plateformes en ligne tel que celui de Twitter, pour n’en citer qu’un, n’aident pas et jouent un rôle clé en montrant aux utilisateurs des sujets qui les intéressent, renforçant de cette manière les informations qu’ils ont déjà lues ou croisées auparavant.

La désinformation peut avoir de lourdes conséquences, puisqu’elle peut influencer notre perception du monde. Pour lutter contre celle-ci, il faut absolument vérifier la source des informations, comparer ces informations avec d'autres sources fiables ainsi que de rester vigilants face aux différents signes de manipulation. Cela demande un peu de temps avant de développer ces réflexes, mais c’est tout à fait faisable, et ce, en partie grâce à la technologie qui y joue un rôle clé ! Les moteurs de recherche et les réseaux sociaux mettent en place des systèmes de vérification des informations.

Les gouvernements peuvent eux aussi jouer un rôle dans la lutte contre la désinformation. Ils peuvent par exemple mettre en place des mécanismes de vérification et de signalement. Les utilisateurs que nous sommes, pourrions également signaler les contenus suspects et les profils qui diffusent de fausses informations.

En conclusion, nous avons tous un rôle à jouer pour combattre ce fléau qu’est la désinformation. Il s’agit avant tout chose de faire attention à ne pas propager nous-mêmes ces informations-là pour le bien de la société. Même si, à la fin, la vérité triomphe toujours.

https://www.canada.ca/fr/campagne/desinformation-enligne.html?utm_campaign=csec-ctsc-online-disinformation-23-24&utm_medium=sem&utm_source=ggl&utm_content=ad-text-fr&utm_term=d%C3%A9sinformation&adv=2324-472201&id_campaign=20556416297&id_source=156443934871&id_content=674167645145&gclid=CjwKCAiA3aeqBhBzEiwAxFiOBuQdYBraIxfd5d4JtXLKSmgNEhY25p9mdHNYNf1JpBs5iRZOgI6JEhoCrccQAvD_BwE&gclsrc=aw.ds

[shuttlecapetown]

CTSC Travel was established in 2008 and provides full transport services throughout South Africa. By applying sound business principals, CTSC Travel will create and secure a future for itself, our staff, our clients, and much needed employment.CTSC Travel offer honest, reliable transportation with no compromise on safety and confidentiality. Come and explore South Africa with CTSC Travel. B-BBEE level 1 contributor.We focus on creating a leading edge service in the Shuttle and Tours market. As a transportation company, CTSC Travel focuses all energy in meeting the required needs within the Western Cape as well as building and strengthening our economy.

[korbae]

natvanlis: I live a very strange, charmed life sometimes where nice people like @coco_mac0724 paint my face when gems like @randy_inc_ ask me to help raise awareness for important campaigns like @free_them_ and it gets me thinking a lot about how there’s so much more I could be doing. Stay tuned for details.

[butterflyutas]

day 1 aight i’m back it wasn’t that bad

[forgeline]

Repost from @continental_tire. That sweet grip of Victory. ✌️ #imsa #ctsc #ford #mustang #gt4 #mustanggt4 #winning #confetti #tires #forwhatyoudo #forgeline #forgelinewheels #forgedwheels #customwheels #forgedmonoblock #GS1R #notjustanotherprettywheel #doyourhomework #madeinUSA #🇺🇸 https://www.instagram.com/p/Bnjafp-HvAk/?utm_source=ig_tumblr_share&igshid=1uj7bcgtelpkb

[covid-safer-hotties]

Also preserved on our archive (Thousands of news, science, and opinion articles on top of links to helpful resources and explainers! Daily updates!)

A new Cleveland Clinic-led study published in The EMBO Journal shows that mild and asymptomatic SARS-CoV-2 infections can trigger immune responses in a pregnant individual that may cause serious inflammatory responses in the developing fetus.

The study's findings also suggest that vertical transmission of the virus from a pregnant individual to the fetus is more common than previously estimated—and that even without this transmission, a pregnant individual's immunological response to infection may impact the fetus.

Typically, health care providers test for SARS-CoV-2 infection, the virus that causes COVID-19, in a newborn through a nasal swab after birth. For this study, Cleveland Clinic researchers collected samples from the placenta and the fetal compartment (tissues that surround a fetus while still in utero), and then analyzed them for the presence of inflammatory markers and the virus.

They found higher instances of the virus in those tissues than what could be found in a traditional nasal swab, and even in the absence of a full infection they found small proteins from the virus had passed through the placenta.

The researchers hope their study will help ensure pregnant individuals can rapidly and reliably receive evidence-based medical care needed during novel outbreaks and public health crises.

When the COVID-19 pandemic first began, OB/GYN Ruth Farrell, MD, and colleagues at Cleveland Clinic and other major medical centers wanted to determine the best way to prevent and manage the infection in their pregnant patients. Pregnant individuals required different medical considerations during the pandemic compared to their nonpregnant counterparts; Dr. Farrell notes that many of the prevention and treatment approaches used in non-pregnant patients either did not have enough data to use in pregnant patients or were not feasible to perform.

"During the early stages of the pandemic, there were significant delays in determining how best to prevent and treat pregnant patients with SARS-CoV-2 infection," explains Dr. Farrell, who also serves as the Vice Chair of Research for Cleveland Clinic's Obstetrics & Gynecology Institute

"These delays lead to gaps in our understandings of the COVID pandemic for pregnant persons. These gaps also contribute to disparities that prevented pregnant individuals from accessing the best possible treatment as quickly as possible during the pandemic."

Dr. Farrell worked with clinical colleagues across the Clinical and Translational Science Collaborative (CTSC) of Northern Ohio to develop methods for examining the impact of SARS-CoV-2 infection on pregnant patients, including researchers from University Hospitals of Cleveland and MetroHealth Medical Center.

She then teamed up with Cleveland Clinic maternal-fetal virologists Jolin (Suan Sin) Foo, Ph.D. and Javier (Weiqiang) Chen, Ph.D. from the Infection Biology Program to determine how the virus impacted the immune systems of both mother and child.

When the standard-of-care COVID-19 test is used to detect the virus in newborns (nasal swabs upon birth), they only detect infections in about 2% of children whose mothers tested positive for the virus during pregnancy. However, when Drs. Chen and Foo looked at tissues that surrounded the newborns when they were still in utero—including the amniotic fluid, chorion and umbilical cord plasma—they detected high levels of the virus in over a quarter (26%) of study participants.

The team also found elevated immune and inflammatory responses affecting the pregnancies of about 66% of study participants. Dr. Foo had previously shown elevated levels of fetal inflammation in pregnant individuals who experience severe SARS-CoV-2 infections during pregnancy, but few had asked whether asymptomatic or mild infections had the same effect. Now that they had their answer, however, the team was faced with even more questions.

"Even though we only saw vertical transmission of the full virus infection a quarter of the time, we saw strong immune and inflammatory responses in over two thirds of the cases," Dr. Foo says. "It was clear that even when the fetuses were not technically infected, they were still being impacted by their mothers' viral infection. But we weren't quite sure how."

Elevated levels of inflammation during pregnancy, in COVID and other conditions, can have negative impacts on the offspring long after birth. Further research can define how inflammation affects children in the long term.

Dr. Chen noted that the SARS-CoV-2 virus has a protein called ORF8 that physically resembles a human immune protein called immunoglobulin G that passes through the placenta from mother-to-fetus during development. He wondered whether the viral protein could also pass through the placenta's defenses to cause inflammation in the fetal compartment.

Drs. Foo and Chen, alongside co-first authors Tamiris Azamor, Ph.D. and Débora Familiar-Macedo, Ph.D. (a former and current postdoctoral researcher, respectively, in Dr. Foo's lab), were able to prove that the virus-made ORF8 did indeed pass through the placenta into the fetus. ORF8 then bound to immune proteins and "turned on" a process called the complementary immune response.

At normal levels, the complement system is a good thing during pregnancy and helps the fetus develop properly, Dr. Familiar-Macedo explains. At higher levels, the complement system can cause dangerous inflammation in a developing fetus. Lab studies supported that this immune response directly led to the elevated levels of inflammation seen in the fetuses of pregnant patients infected with the SARS CoV-2 virus.

"Our findings challenge the currently accepted definition of vertical transmission, or what it means to transmit an infection from mother-to-fetus," Dr. Chen says. "We have shown that it is indeed possible for only a small part of a virus to slip through and affect a pregnancy."

Dr. Foo adds that she hopes her team's findings will serve as guidance for health care practitioners, researchers and policymakers alike on further research into vertical transmission and long-term care.

"We've shown that the misconception that uninfected babies born from infected mothers are fine, is sometimes just that: a misconception," she says. "Pregnancy is such a vulnerable nine-month period where any change from the norm can cause long-term impacts on the baby, so we need to work more closely with these individuals to understand their unique health care needs during public health crises. It's the only way to make sure they receive the care they need."

More information: Tamiris Azamor et al, Transplacental SARS-CoV-2 protein ORF8 binds to complement C1q to trigger fetal inflammation, The EMBO Journal (2024). DOI: 10.1038/s44318-024-00260-9 www.embopress.org/doi/full/10.1038/s44318-024-00260-9

[sudden-stops-kill]

mustang

[barclayitaly]

Key Benefits and Results In the quest for healthier, shinier, and more manageable hair, keratin conditioner has emerged as a game-changer. Rich in keratin—a key protein that makes up your hair, skin, and nails—this conditioner offers a multitude of benefits that can revitalize and transform your hair. In this blog, we’ll explore the key benefits of keratin conditioner, how it works, and how to use it effectively to achieve stunning results.

Key Benefits of Keratin Conditioner

1. Strengthens and Repairs Hair:

• Keratin is the building block of your hair, and using a keratin conditioner helps to replenish and reinforce these essential proteins. This strengthens the hair shaft, reducing breakage and split ends, and helps repair damage caused by heat styling, chemical treatments, and environmental factors.

2. Adds Shine and Smoothness:

• One of the most noticeable benefits of keratin conditioner is its ability to add a natural shine and smoothness to your hair. The keratin helps to fill in gaps and smooth the hair cuticle, resulting in a glossy, polished finish and a reduction in frizz.

3. Enhances Manageability:

• With its smoothing and strengthening properties, keratin conditioner makes hair more manageable and easier to style. It helps detangle knots and reduces the time needed for styling, making your hair routine quicker and more efficient.

Description

BarclayItaly’s Keratin Conditioner is specially designed for all hair types. Enriched with 2% Keratin to strengthen and repair, 2% Argan Oil for deep nourishment, 2% Quinoa Water for hydration, and 2% Bamboo Silica to boost shine and resilience, this conditioner revitalizes your hair from root to tip.

Formulated with 100% natural, alcohol-free, and sulfate-free ingredients, our conditioner is vegan, cruelty-free, and free from harsh chemicals or synthetic fragrances. Herbal and plant-based, it provides the perfect blend of moisture and protection, leaving your hair soft, smooth, and full of bounce.

Say goodbye to breakage and dryness and hello to stronger, healthier, and shinier hair. BarclayItaly’s Keratin Conditioner will help you naturally achieve beautiful, nourished locks.

Ingredients

2% Keratin + 2% bamboo silica + 2% Argon oil + 2% Quinoa water , Aqua, EDTA, CTSC ( conditioning agent), emulsifying wax, mango wax, shea butter, vegetable glycerin, aloe vera extract, ritha extract, heena extract, sodium gluconate (cleansing agent), BHT, almond oil, argan oil, sunflower oil, UCURE (conditioning agent and thickner), perfume/essential oil

Usage Instructions

After shampooing, apply a generous amount of conditioner to wet hair, focusing on the mid-lengths to ends. Leave on for 2-3 minutes, then rinse thoroughly. For best results, use after our Keratin Sham

[miniusa]

TBT to a pit stop for #73 at Lime Rock Park. The MINI John Cooper Works Racing Team gears up for its second four-hour endurance race of the season in CTSC! Watch the MRLS 240 live 9/23 at 5 p.m. ET on IMSA.tv or the IMSA mobile app.

[himzach1]

Owen Trinkler’s ride at Watkins Glen International garage 2017

[guitar-ijiri-house]

Creatifinity Partsの極厚スプリングハンガーブラス&ベルブラスでサウンドチューニング！

 [CP] ギター用 スプリングハンガー ベルブラス とブラスで音はどう変わるの？[音質改善] _ ギターいじリストのおうち https://guitar-ijiri.com/blog/data/creatifinity-parts-bellbrass-spring-hanger-ctsc-1b/