#cocaine vaccine

[planetabio]

Esperança contra a recaída: vacina anticocaína e anticrack.

Um verdadeiro drama! Talvez esta seja a forma mais branda de descrever o sofrimento dos dependentes e seus familiares na tentativa de se livrar das "garras" da cocaína e drogas derivadas, como o crack.

Segundo a Organização das Nações Unidas (ONU), 18 milhões de pessoas no mundo consomem cocaína. Aproximadamente 25% desses usuários vão se tornar dependentes da droga. O Brasil é o segundo maior consumidor de cocaína do mundo, perdendo apenas para os Estados Unidos.

Claro que a raiz do problema está na produção e tráfico ilegais de cocaína gerenciados por poderosas organizações criminosas. Tentar combater a epidemia de cocaína e de crack nas cidades, na sociedade, nas famílias, sem adotar medidas de combate ao financiamento e à logística do tráfico de drogas é "tapar o sol com a peneira". No entanto, o que queremos aqui é mostrar mais uma promissora medida preventiva contra o consumo de cocaína e derivados.

Muita gente vai dizer ou pensar de forma correta que a educação, o lazer e o esporte, além da convivência harmoniosa entre as pessoas são os principais instrumentos para a prevenção contra o uso de drogas e todo o caminhão de malefícios que elas trazem.

Por sua vez, a ciência está nos mostrando uma outra poderosa arma preventiva contra as drogas: a vacina! Porém, antes de falarmos sobre ela, que tal se déssemos uma lembradinha de como a cocaína age em nosso cérebro?

A cocaína (cloridrato de cocaína) é uma potente droga estimuladora do sistema nervoso central, que bloqueia os canais de recaptação de dopamina (neurotransmissor ligado ao prazer) localizados na membrana plasmática dos neurônios pré-sinápticos. Assim, a cocaína provoca indiretamente "excesso" de dopamina na fenda sináptica, o que significa maior tempo de estimulação dos neurônios pós-sinápticos. Ocorre que todo esse processo é mais frequente nas áreas cerebrais ligadas ao chamado "sistema de recompensa". Nessas áreas, quanto "maior for a presença de cocaína, maior será o tempo de permanência da dopamina, o que resultará em mair sensação de prazer!"

O fato é que o mundo pode parecer "chato" para um usuário de cocaína quando ele não está utilizando a droga. "Dois palitos" para que ele volte a procurar a droga para se sentir "poderoso". Essa é a força motriz da dependência química!

A cocaína dura para sempre no organismo humano? Não, o fígado degrada a cocaína transformando-a em outros metabólitos. Em geral, o cloridrato de cocaína tem meia vida entre 30 e 90 minutos, porém os metabólitos originários da degradação da cocaína podem permanecer no organismo atuando por períodos mais longos.

Claro que o tratamento ideal para diminuir a dependência de cocaína passa pelo não consumo da droga, tarefa nem um pouco simples. Apoio da família, supervisão profissional e modo de vida harmonioso são os alicerces para enfrentar a dependência química.

E sim, é possível se livrar do vício dessa droga!

A ciência acena com grandes possibilidades terapêuticas. Já pensou se, de alguma forma, algum medicamento bloqueasse as recaídas, isto é, a vontade de obter novamente cocaína? A boa notícia é que pesquisadores de vários lugares do mundo, inclusive do Brasil, estão tentando desenvolver uma vacina contra a cocaína e drogas derivadas. Isto é fantástico!

A ideia é "aplicar" um antígeno (no caso seria a união da cocaína com algum tipo de proteína transportadora) no organismo do dependente químico para que ocorra uma resposta imunológica, isto é, a produção de anticorpos específicos contra a cocaína, além de uma memória imunológica por meio da formação de linfócitos de memória.

Nessa perspectiva, o usuário imunizado (vacinado) que tivesse, por alguma razão, uma recaída e que se drogasse, desta vez não sentiria (ou sentiria bem pouco) os efeitos prazerosos da droga, pois seu organismo seria capaz de lançar (ou produzir) anticorpos que se acoplariam à cocaína formando um complexo molecular muito grande, incapaz de transpor a barreira hematoencefálica e produzir algum efeito psicoativo no cérebro.

Bem, talvez você esteja se perguntando: o que é essa tal de barreira hematoencefálica?

Trata-se de uma estrutura formada por células endoteliais (tecido endotelial) que revestem os vasos sanguíneos que irrigam o sistema nervoso central, especialmente o cérebro. As células endoteliais têm alto poder de adesão entre elas, pois são unidas por diferenciações da membrana plasmática que limitam a passagem de moléculas e íons do sangue para o cérebro. Assim, a barreira hematoencefálica protege o cérebro, impedindo que determinadas toxinas e micro-organismos presentes na corrente sanguínea consigam penetrar no sistema nervoso central. A cocaína consegue passar por essa barreira.

Tendo como base a premissa descrita, a vacina anticocaína induz o organismo a produzir anticorpos que se acoplam à cocaína (e proteínas transportadoras) para formar complexos moleculares grandes que não atravessam totalmente a barreira hematoencefálica. Isso é bom, pois em tese a cocaína fica impedida de agir nas áreas cerebrais ligadas ao sistema de recompensa, diminuindo a presença de dopamina na fenda sináptica e limitando a "vontade" de experimentar novamente a droga.

Certo, mais em quais lugares do mundo há cientistas pesquisando a tão promissora vacina anticocaína?

Estados Unidos: universidades e instituições de pesquisa estadunidenses têm realizado estudos e ensaios clínicos para o desenvolvimento de vacinas contra a cocaína, dentre elas: Mayo Clinic, Baylor College of Medicine e Scripps Research.

Europa: países europeus, como o Reino Unido, a Alemanha, a Suíça e a Espanha, também apresentam instituições de pesquisa envolvidas no desenvolvimento de vacinas contra a cocaína, dentre elas: King's College London e a Universidade de Basileia.

Canadá: a University of British Columbia anunciou linhas de pesquisa nessa área.

China: os chineses investem em pesquisas relacionadas à vacina contra a cocaína, além de outras abordagens terapêuticas para fins preventivos.

Brasil: a gloriosa Faculdade de Medicina da Universidade Federal de Minas Gerais (UFMG) vem desenvolvendo também uma vacina contra a cocaína, utilizando matéria prima importada dos Estados Unidos. Isso ocorre porque, por foça de Lei, é proibida a utilização de cocaína no Brasil, mesmo para finalidade científica.

A vacina "mineira" contra a cocaína, batizada de "Calixcoca", demonstrou segurança e eficácia em estudos pré-clínicos com a utilização de animais em laboratório, inclusive mostrou-se segura na gravidez, resultando na produção de uma série de anticorpos que impediram a ação da droga sobre a placenta e fetos de ratas grávidas.

A Calixcoca vem chamando a atenção das autoridades sanitárias. A Prefeitura de São Paulo anunciou ajuda financeira aos pesquisadores mineiros para o desenvolvimento das fases sequentes da produção dessa vacina, inclusive com ensaios em humanos voluntários. Mas até à aprovação da vacina pela ANVISA "tem chão"! Alguns anos ainda serão necessários.

Fala a verdade, a ciência não é fantástica?

Leia também:

1-https://www.medicina.ufmg.br/vacina-para-dependencia-de-cocaina-e-crack-e-finalista-em-premio-de-inovacao-tecnologica/

2-UFMG cria vacina para dependentes de crack e cocaína - Sechat

3-https://www.medicina.ufmg.br/vacina-para-dependencia-de-cocaina-e-crack-e-finalista-em-premio-de-inovacao-tecnologica/

4-https://exame.com/ciencia/vacina-brasileira-contra-dependencia-em-crack-e-cocaina-e-finalista-de-premio-internacional/

5-https://www.sciencedirect.com/science/article/abs/pii/S0264410X20313359

6-https://g1.globo.com/saude/noticia/2023/05/22/vacina-contra-dependencia-de-drogas-em-desenvolvimento-pela-ufmg-pode-ser-eficaz-em-bebes-de-gestantes-usuarias.ghtml

[dontmean2bepoliticalbut]

[mindblowingscience]

Scientists in Brazil, the world's second-biggest consumer of cocaine, have announced the development of an innovative new treatment for addiction to the drug and its powerful derivative crack: a vaccine. Dubbed "Calixcoca," the test vaccine, which has shown promising results in trials on animals, triggers an immune response that blocks cocaine and crack from reaching the brain, which researchers hope will help users break the cycle of addiction. Put simply, addicts would no longer get high from the drug. ​If the treatment gets regulatory approval, it would be the first time cocaine addiction is treated using a vaccine, said psychiatrist Frederico Garcia, coordinator of the team that developed the treatment at the Federal University of Minas Gerais. ​The project won top prize last week – 500,000 euros ($530,000) – at the Euro Health Innovation awards for Latin American medicine, sponsored by pharmaceutical firm Eurofarma. ​The vaccine works by triggering patients' immune systems to produce antibodies that bind to cocaine molecules in the bloodstream, making them too large to pass into the brain's mesolimbic system, or "reward center," where the drug normally stimulates high levels of pleasure-inducing dopamine.

Continue Reading

[computerexploder]

[truth4ourfreedom]

THINGS NOT IN THE NEWS ANYMORE. VERSION 6.0

Things not in the news anymore….

(Version 6)

-Maui wildfires. -East Palestine, Ohio -Joe Biden classified documents as a Senator. -Fauci working with China to create a bioweapon. -Pete Buttigieg’s best friend in prison for child porn. -Cocaine in the White House. (TWICE NOW) -The BLM and Antifa riots during 2020 causing BILLIONS of dollars of damage. -The data collected from the Chinese spy balloons. -Ukraine intelligence documents released that showed they were suffering massive losses and the American taxpayer was being lied to. -Nancy Pelosi’s “documentary” film crew on J6. -Veterans being kicked out of shelters to make room for illegals. -Pizzagate “debunker” jailed for possession of child pornography. -Gay porn film in Senate hearing room. -Veterans Affairs prioritizing healthcare of illegals over Veterans. -THE SOUTHERN BORDER CRISIS. -Afghanistan drawdown and 13 service members killed in an attack on Kabul International Airport, that they hid the severity of it. -Obama droning an American citizen in the Middle East. -George Bush’s false WMDs. -3 service members killed in Jordan. -Hunter Biden making over $1M for “paintings”. -J6 political prisoners that are still in jail. -85,000 missing children at the southern border. -Epstein’s clients. -Obama coordinating with John Brennan and 4 other countries (5 eyes) to spy on the 2016 Trump campaign. -Mail-in ballots were the cause of the stolen 2020 election. -Jeffrey Epstein mentioning that Bill Clinton liked his girls “really young”. -The (NOW TWO) airline whistleblowers that mysteriously died. -Benghazi (I won’t mention anything more about this because I care about my life.) -Nancy Pelosi’s daughter stating that January 6th wasn’t an insurrection. -The January 6th committee destroying encrypted evidence before the GOP took over the House. -Nancy Pelosi admitting that J6 was “her responsibility”. -House Speaker Mike Johnson claiming there wouldn’t be foreign aid without border security in the bill, which was a lie. -The recent riots from illegal criminal aliens at the southern border and the border in general. -Hunter Biden not complying with a Congressional subpoena and deemed untouchable. Democrat privilege. -Vaccine side effects. -“Lab leak” out of China -The Secret Service having to basically guide Joe Biden everywhere he goes. -Who leaked (Sotomayor) the SCOTUS Alito decision. -Federal instigators inside the Capitol including pipe bomb evidence against them. -Obama’s chef “passing away”. -HRC’s chef “passing away”. -The Sheriff that happened to be in Las Vegas (during the mass shooting) AND the wildfires in Hawaii. -P Diddy sex-trafficking allegations. Where’s Diddy? -Gonzalo Lira (an American journalist) that was killed in Ukraine -Congress approving warrantless spying violating American’s 4th amendment rights while they are exempt. -Americans that were left in foreign countries (Haiti, Palestine, Afghanistan). -The billions of dollars of weaponry left in Afghanistan and the Taliban receiving $40M a week in “humanitarian assistance”. -Biolabs found in California. -Joe Biden’s impeachment. -The scum in the UNITED STATES HOUSE OF REPRESENTATIVES waving the Ukrainian flag. -The over 300k ballot images that could not be found in Fulton County, Georgia; the same county Donald Trump on trial for “election interference”. -Democrats defunding the police causing massive rises in crime. -Kamala Harris’s record as DA in California. -The Transifesto from the school shooting. -Many U.S. Representatives and Congress receiving FTX funds. -They’re already working hard to bury Donald Trump’s àssassination attempt but we won’t let them bury that story. July 13th is never going away.

The distractions are out of control.

Share to show that legacy media is dead and that WE are the media now.

Please like,share and reblog to keep people aware!

[silverfroot]

Brazil has free college. And it's GREAT. UFMG university is now making a vaccine against crack and cocaine. The sim is to help with our problem with violence and people's addiction. The Crackolandia is a problem as your meth users there.

So UFMG may actually help with public security and our public health. Education is an investment for the people.

But USA government only cares to a few billionaires, not the people.

That's just fucking wrong!!

[reality-detective]

Things that are not in the news anymore… 👇

-Maui wildfires.

-East Palestine, Ohio

-Joe Biden classified documents as a Senator.

-Fauci working with China to create a bioweapon.

-Pete Buttigieg’s best friend in prison for child porn.

-Cocaine in the White House. (TWICE NOW)

-The BLM and Antifa riots during 2020 causing BILLIONS of dollars of damage. And yes I brought this up on Juneteenth.

-The data collected from the Chinese spy balloons.

-Ukraine intelligence documents released that showed they were suffering massive losses and the American taxpayer was being lied to.

-Nancy Pelosi’s “documentary” film crew on J6.

-Veterans being kicked out of shelters to make room for illegals.

-Pizzagate “debunker” jailed for possession of child pornography.

-Gay porn film in Senate hearing room.

-Veterans Affairs prioritizing healthcare of illegals over Veterans.

-THE SOUTHERN BORDER CRISIS.

-Afghanistan drawdown and 13 service members killed in an attack on Kabul International Airport, that they hid the severity of it.

-Obama droning an American citizen in the Middle East.

-George Bush’s false WMDs.

-3 service members killed in Jordan.

-Hunter Biden making over $1M for “paintings”.

-J6 political prisoners that are still in jail.

-85,000 missing children at the southern border.

-Epstein’s clients.

-Obama coordinating with John Brennan and 4 other countries (5 eyes) to spy on the 2016 Trump campaign.

-Mail-in ballots were the cause of the stolen 2020 election.

-Jeffrey Epstein mentioning that Bill Clinton liked his girls “really young”.

-The (NOW TWO) airline whistleblowers that mysteriously died.

-Benghazi (I won’t mention anything more about this because I care about my life.)

-Nancy Pelosi’s daughter stating that January 6th wasn’t an insurrection.

-The January 6th committee destroying encrypted evidence before the GOP took over the House.

-Nancy Pelosi admitting that J6 was “her responsibility”.

-House Speaker Mike Johnson claiming there wouldn’t be foreign aid without border security in the bill, which was a lie.

-The recent riots from illegal criminal aliens at the southern border and the border in general.

-Hunter Biden not complying with a Congressional subpoena and deemed untouchable. Democrat privilege.

-Vaccine side effects.

-“Lab leak” out of China.

-The Secret Service having to basically guide Joe Biden everywhere he goes.

-Who leaked (Sotomayor) the SCOTUS Alito decision.

-Federal instigators inside the Capitol including pipe bomb evidence against them.

-Obama’s chef “passing away”.

-HRC’s chef “passing away”.

-The Sheriff that happened to be in Las Vegas (during the mass shooting) AND the wildfires in Hawaii.

-P Diddy sex-trafficking allegations. Where’s Diddy?

-Gonzalo Lira (an American journalist) that was killed in Ukraine

-Congress approving warrantless spying violating American’s 4th amendment rights while they are exempt.

-Americans that were left in foreign countries (Haiti, Palestine, Afghanistan).

-The billions of dollars of weaponry left in Afghanistan and the Taliban receiving $40M a week in “humanitarian assistance”.

-Biolabs found in California.

-Joe Biden’s impeachment.

-The scum in the UNITED STATES HOUSE OF REPRESENTATIVES waving the Ukrainian flag.

-The over 300k ballot images that could not be found in Fulton County, Georgia; the same county Donald Trump on trial for “election interference”.

-Democrats defunding the police causing massive rises in crime.

-Kamala Harris’s record as DA in California.

-The Transifesto from the school shooting.

-Many U.S. Representatives and Congress receiving FTX funds.

-They’re already working hard to bury Donald Trump’s àssassination attempt but we won’t let them bury that story. July 13th is never going away.

The distractions are out of control.

Share to show that legacy media is dead and that WE are the media now. 🤔

[phoenixremix69]

The PJO fandom really is neglecting the inherent comedy of Nico being from the forties and dating a doctor

He has zero idea what a vaccine even is. He haz no clue what PTSD is and thinks he's just hysterical and needs to balance his humors. When he heard they took the cocaine out of coke, he went to a shady dealer so he could mix it in himself because he misses the flavor. Will has just...so much work to do

[paraphwrites]

historical events edwin wouldn't know about

the fall of the ottoman empire, invention of birth control, the moon landing, the holocaust, women's suffrage, decolonization, the cold war, discovery of pluto, the sexual revolution, invention of nuclear bombs, polio vaccine...

and, look, i wager that between their cases, these events would come up. but, like, every once and a while edwin just does not believe charles.

"what do you mean america is a global superpower?! it is practically a baby. you must be wrong, charles."

"that's a stupid number of revolutions. you're having a go at me."

"they discovered another planet? impossible. then they changed their mind? that's simply ludicrous."

like i've seen a lot of fics where edwin is like "oh you're sick? go get some cocaine :)" but never any where edwin is like "crystal what do you MEAN you're going to VOTE? you're a WOMAN"

[pippsbeb]

i want reporters to ask trump:

have you consumed any drugs this year? have you ever snorted cocaine? when is the last time you had any drug? have you read any books this year? do you regret getting the covid vaccine? would you appoint again any of your former cabinet members? would you appoint giuliani or bannon to any posts? would you pardon any of the jan 6ers that were convicted of assaulting police officers? what do you think of combovers? what do you think of shoe lifts? are your dentures giving you less trouble these days? would laura loomer be a good first lady? have you considered replacing jd vance? should felons be allowed to vote? is it true that you wear diapers? what do you think of lindsey graham? ted cruz? should people vote for them? or for desantis? did you have sex with anyone at the epstein island? do you believe he commited suicide?

asking questions is not illegal.

why are reporters walking over eggshells and trying to make sense of his verbal diarrhea? a guy i know was a reporter for a while, and he said it's amazing the things people will tell you if you just ask.

[freshcuntgrass]

An unflattering assumption I have about every NPC in Stardew Valley

Sam: gave Gus a fake ID to get alcohol. Jodi never goes to the saloon and Kent is afraid he forgot how old Sam is, so he's never getting called on it

Sebastian: has ruined at least one online D&D group playing an edgy lone-wolf rogue with no parents

Maru: still brings up her SAT score in conversation sometimes

Demetrius: has the Neil deGrasse Tyson thing going where he assumes every field is easy because he's good at biology. Maru finds this endearing with her gadgets; he is banned from looking at Sebastian's code

Wizard: same as Demetrius but ten times worse

Robin: first marriage ended because she slept with the wizard (Sebastian is his). What can I say, she likes em brilliant, socially awkward, and just a little insufferable

Clint: you KNOW this man's on Reddit and you KNOW he does not have a healthy relationship with it. I am begging Sebastian to "fix some tech problems for him" (install a secret browser extension block on the manosphere subreddits)

Elliott: hair-trigger crier. Poems, books, the end of every rom-com, songs you do not think it should be possible to cry during, noticed the cat sleeping in a really cute way, remembers that he lives near the ocean... honestly he'd have a lot more written by now if his entire day wasn't taken up by crying and hair care

Willy: has lived alone too long, holds conversations with most objects in his house

Leah: has NEVER swept or mopped the floor of that cabin. You can't see it in the pixel art but it's a biohazard

Pierre: Twitter power-user, unironically calls it X

Caroline: doing her own research on the COVID vaccine

Haley: Swiftie

Penny: even bigger Swiftie

Abigail: Homestuck

Alex: media literacy so bad he doesn't realize the insane homoeroticism of Top Gun

Harvey: terrified that someone in town will look closer at the degree on his wall and realize he's technically an RN, not a doctor, and then it'll just be awkward

Lewis: that truffle oil was for pegging

Evelyn: "secret family recipe" is boxed chocolate cake mix with mayonnaise instead of the oil

George: Hey... um... hey guys? Where was George on January 6th?

Pam: Hey guys, where was Pam on January 6th???

Gus: definitely drunk behind that bar most of the time. He gets away with it because it comes across as "jolly"

Linus: can't go back to Zuzu City. He knows what he did

Jodi: biggest Swiftie of them all. She name-searches. Yes, she's still on Tumblr. Hi Jodi, your fave is mid, looking forward to the anon hate :)

Kent: agrees with Alex that Top Gun isn't gay. Nothing's gay in the military

Sandy: unreal amount of mobile gaming going on back behind that counter. stop sending me Farmville requests

Marnie: actually accepts Sandy's Farmville requests. Keeps texting Shane minion memes

Shane: the real unflattering assumption with Shane is when you correctly clock a fellow Stardew Valley player as a Shane girlie. In our defense, he's going through a lot and we can fix him.

Krobus: eats those void eggs raw. Cracks the shell and drinks em. Slurp slurp bitch

Dwarf: honestly HUGE drug dealer vibes. Miner's Treat has got to be the dwarves' version of cocaine, right?

Vincent and Jas: safe for now, I don't roast anybody under 12. once we hit like year 5 I'm coming for you though

Emily: wants to reblog this but can't. her queue is full and she's hit post limit

[wings-1927]

actually re : the victorian children post i think the internet severely overestimates the impact most things would have on a victorian child.

like say you’re a child in victorian england and you have reached the age of nine. even if you’re upper-class, you’ve survived swill milk, cough medicine with cocaine in it, mercury in all your clothes, arsenic in all your walls, probably a cholera/typhus/scarlet fever/whatever outbreak (with no vaccines !)… you’ve made it past five, which is a feat, considering the high infant mortality rates. it’s even worse if you’re lower-class, because you’d probably also, on top of all that, survived 10-hour workdays with no labour laws for an absolute pittance. these kids were resilient.

and don’t think they’d be affected by whatever weird online drama either. folks in the victorian era had to keep track of what the british aristocracy was up to. tenant farmers remembering who had what courtesy title and what honorifics to use for them on a productivity check visit could mean the difference between keeping and losing your farm. knowing who was next in the line of succession of the unmarried duke who owned your house would have been probably pretty important. these people read about jack the ripper for fun. they would be able to deal with your mcytwt cc drama no sweat.

[eurodyning]

Six Song Soundtrack - Tyrell "Orion" Cormier

Rules: If you're tagged, make a new post with links to music and/or lyrics describing the following:

An event that defines your character’s past: Father - The Front Bottoms

I believe that, yeah, Dad, maybe no one is perfect But I believe that you were pushing your luck It just sucks it played out like this A terrible movie and you can tell none of the actors even give a fuck

The Father Complex - Many Rooms

I bet you're looking for a "sorry" I'm looking for one too What goes on inside your heart? What makes you do the things you do? Do you really talk to God? Man, I wonder what he tells you Maybe he has given up The way that I gave up too Well, I hope that you're happy Without me

How to Never Stop Being Sad - dandelion hands

My life is shit because I deserve it, right? You must have done something real bad

Allow yourself to lose interest in the things you love Watch as you begin to take a backseat to the world around you, don't fight it Become a secondary character in your own motion picture But most importantly Drown every single one of your feelings in old stolen rum Learn to love the taste of it dripping down your throat Find comfort in the warmth coming from your stomach You're drinking bottled love now You don't need other people to drive away your loneliness

How your character sees themselves: Toxic Thoughts - Faith Marie

If this isn't right Then does that mean I failed? Will my melodies ever live up? Will my metaphors be profound enough? Will I ever outdo myself? The ceiling gets higher and higher It's harder and harder to shatter And when I fall I fall worse than I ever did before

How others view them: Art Hoe - Call Me Karizma

5'4", black hair, never had her dad there Kissed a lot of boys but Never seems to have care She just wants vodka and cigarettes Has the dealer on speed-dial when she gets stressed

Wakes up at noon Gets up when she has to Makeup on her nightstand Cocaine in her bathroom She just wants love that she never gets Has my number on speed-dial when she needs sex

Their closest relationship (platonic or romantic): Young American -The Vaccines

Hold me in the grips of your jaw So you can show me what my mouth is for Suffocate me in between your thighs And take me swimming, naked, in your eyes

Pull me into orbit with your hands Then show me where you wanted me to land

Heavy and aggressive, I'm your thug So easy and obsessive, I'm your drug

A major fight scene: Move Like U Stole It (Remix) - Z Ward, Paul Oakenfold

Can't wait another mile The world ain't ending but it might as well be I'll rock you like the sea Buildings ain't crumbling but they might as well be So let's not think and just Move like you stole it Move, hurry Move like you stole it Make your move on me

End Credits: In the Modern World - Fontaines D.C.

In the modern world I don't feel anything in the modern world I don't feel bad Kissing on the corner Wait for just a minute I don't feel bad I feel alive in the city you despise

tagged by @aztarion thank you jez! ❤️

a toreador (🚩) with substance abuse and father issues? well i never. as expected i couldn't stick to the six song limit. have a sunny crossover meme i threw together in a minute

i've never talked about my boy tyrell on here before but maybe i will post more about my ocs in time. tagging: @psych0ruinz and anybody else who would like to play!!

dividers by @diableriedoll !!

[ralfmaximus]

Here's the complete list of DHS flagged search terms. Don't use any of these on social media to avoid having the 3-letter agencies express interest in your activities!

DHS & Other Agencies

Department of Homeland Security (DHS)

Federal Emergency Management Agency (FEMA)

Coast Guard (USCG)

Customs and Border Protection (CBP)

Border Patrol

Secret Service (USSS)

National Operations Center (NOC)

Homeland Defense

Immigration Customs Enforcement (ICE)

Agent

Task Force

Central Intelligence Agency (CIA)

Fusion Center

Drug Enforcement Agency (DEA)

Secure Border Initiative (SBI)

Federal Bureau of Investigation (FBI)

Alcohol Tobacco and Firearms (ATF)

U.S. Citizenship and Immigration Services (CIS)

Federal Air Marshal Service (FAMS)

Transportation Security Administration (TSA)

Air Marshal

Federal Aviation Administration (FAA)

National Guard

Red Cross

United Nations (UN)

Domestic Security

Assassination

Attack

Domestic security

Drill

Exercise

Cops

Law enforcement

Authorities

Disaster assistance

Disaster management

DNDO (Domestic Nuclear Detection Office)

National preparedness

Mitigation

Prevention

Response

Recovery

Dirty Bomb

Domestic nuclear detection

Emergency management

Emergency response

First responder

Homeland security

Maritime domain awareness (MDA)

National preparedness initiative

Militia

Shooting

Shots fired

Evacuation

Deaths

Hostage

Explosion (explosive)

Police

Disaster medical assistance team (DMAT)

Organized crime

Gangs

National security

State of emergency

Security

Breach

Threat

Standoff

SWAT

Screening

Lockdown

Bomb (squad or threat)

Crash

Looting

Riot

Emergency Landing

Pipe bomb

Incident

Facility

HAZMAT & Nuclear

Hazmat

Nuclear

Chemical Spill

Suspicious package/device

Toxic

National laboratory

Nuclear facility

Nuclear threat

Cloud

Plume

Radiation

Radioactive

Leak

Biological infection (or event)

Chemical

Chemical burn

Biological

Epidemic

Hazardous

Hazardous material incident

Industrial spill

Infection

Powder (white)

Gas

Spillover

Anthrax

Blister agent

Exposure

Burn

Nerve agent

Ricin

Sarin

North Korea

Health Concern + H1N1

Outbreak

Contamination

Exposure

Virus

Evacuation

Bacteria

Recall

Ebola

Food Poisoning

Foot and Mouth (FMD)

H5N1

Avian

Flu

Salmonella

Small Pox

Plague

Human to human

Human to ANIMAL

Influenza

Center for Disease Control (CDC)

Drug Administration (FDA)

Public Health

Toxic

Agro Terror

Tuberculosis (TB)

Agriculture

Listeria

Symptoms

Mutation

Resistant

Antiviral

Wave

Pandemic

Infection

Water/air borne

Sick

Swine

Pork

Strain

Quarantine

H1N1

Vaccine

Tamiflu

Norvo Virus

Epidemic

World Health Organization (WHO and components)

Viral Hemorrhagic Fever

E. Coli

Infrastructure Security

Infrastructure security

Airport

CIKR (Critical Infrastructure & Key Resources)

AMTRAK

Collapse

Computer infrastructure

Communications infrastructure

Telecommunications

Critical infrastructure

National infrastructure

Metro

WMATA

Airplane (and derivatives)

Chemical fire

Subway

BART

MARTA

Port Authority

NBIC (National Biosurveillance Integration Center)

Transportation security

Grid

Power

Smart

Body scanner

Electric

Failure or outage

Black out

Brown out

Port

Dock

Bridge

Canceled

Delays

Service disruption

Power lines

Southwest Border Violence

Drug cartel

Violence

Gang

Drug

Narcotics

Cocaine

Marijuana

Heroin

Border

Mexico

Cartel

Southwest

Juarez

Sinaloa

Tijuana

Torreon

Yuma

Tucson

Decapitated

U.S. Consulate

Consular

El Paso

Fort Hancock

San Diego

Ciudad Juarez

Nogales

Sonora

Colombia

Mara salvatrucha

MS13 or MS-13

Drug war

Mexican army

Methamphetamine

Cartel de Golfo

Gulf Cartel

La Familia

Reynose

Nuevo Leon

Narcos

Narco banners (Spanish equivalents)

Los Zetas

Shootout

Execution

Gunfight

Trafficking

Kidnap

Calderon

Reyosa

Bust

Tamaulipas

Meth Lab

Drug trade

Illegal immigrants

Smuggling (smugglers)

Matamoros

Michoacana

Guzman

Arellano-Felix

Beltran-Leyva

Barrio Azteca

Artistics Assassins

Mexicles

New Federation

Terrorism

Terrorism

Al Queda (all spellings)

Terror

Attack

Iraq

Afghanistan

Iran

Pakistan

Agro

Environmental terrorist

Eco terrorism

Conventional weapon

Target

Weapons grade

Dirty bomb

Enriched

Nuclear

Chemical weapon

Biological weapon

Ammonium nitrate

Improvised explosive device

IED (Improvised Explosive Device)

Abu Sayyaf

Hamas

FARC (Armed Revolutionary Forces Colombia)

IRA (Irish Republican Army)

ETA (Euskadi ta Askatasuna)

Basque Separatists

Hezbollah

Tamil Tiger

PLF (Palestine Liberation Front)

PLO (Palestine Libration Organization)

Car bomb

Jihad

Taliban

Weapons cache

Suicide bomber

Suicide attack

Suspicious substance

AQAP (Al Qaeda Arabian Peninsula)

AQIM (Al Qaeda in the Islamic Maghreb)

TTP (Tehrik-i-Taliban Pakistan)

Yemen

Pirates

Extremism

Somalia

Nigeria

Radicals

Al-Shabaab

Home grown

Plot

Nationalist

Recruitment

Fundamentalism

Islamist

Weather/Disaster/Emergency

Emergency

Hurricane

Tornado

Twister

Tsunami

Earthquake

Tremor

Flood

Storm

Crest

Temblor

Extreme weather

Forest fire

Brush fire

Ice

Stranded/Stuck

Help

Hail

Wildfire

Tsunami Warning Center

Magnitude

Avalanche

Typhoon

Shelter-in-place

Disaster

Snow

Blizzard

Sleet

Mud slide or Mudslide

Erosion

Power outage

Brown out

Warning

Watch

Lightening

Aid

Relief

Closure

Interstate

Burst

Emergency Broadcast System

Cyber Security

Cyber security

Botnet

DDOS (dedicated denial of service)

Denial of service

Malware

Virus

Trojan

Keylogger

Cyber Command

2600

Spammer

Phishing

Rootkit

Phreaking

Cain and abel

Brute forcing

Mysql injection

Cyber attack

Cyber terror

Hacker

China

Conficker

Worm

Scammers

Social media

SOCIAL MEDIA?!

[areyouafraid]

my honest opinion yeah im bummed as everyone else it didnt kill him but honest to christ after i watched him get covid whenever he was like 200 years old and knowing his blood has a higher volume of cocaine molecules than erythrocytes and they still managed to resuscitate him (im pretty sure it was actually before the vaccine rolled out iirc so they were just pumping him with a cocktail of experimental drugs & praying) and he still like survived, i'm inclined to believe he'll just live forever at this point. if the bullet had hit him head on and sprayed his brain across the stage and he walked up to the podium the next day with a comically large bandage over the hole in his skull i dont think id even be shocked. we're all gonna be 60 living in an authoritarian commune in the province of Neo New York on mars after billionaires accidentally killed all life on earth and still have images of donald trump's convulsing head in a mason jar airdropped to our state mandated brain implants

[teal-sharky]

All this generic alt-history fiction is F-15s this, gunpowder that.

If I had the time machine and time to prep a know how packet, I'd go to ~1200AD and grow a mercenary-merchant fleet of catamaran hulled ships.

The cornerstone of my fleet would be super-ship-biscuit with mixed in coffee (kills the weevils, keeps the sailors sharp), fortified with vitamin C (lemons, not limes) and nicotine (keeps the men sharp and under my control - leaving the ranks means withdrawal). There would be forbidden red biscuit (added cocaine) and blue biscuit (added heroine) for when things get extra rough.

I'd grow penicillin to demonstratively protect my crews from plagues even god cannot or will not stop as a stopgap while running extremely aggressive vaccination research (It'd go so much faster with liberal usage of orphans for experiments/culture growth; you could get so many fucking orphans back then, they were just free)

All the ranks would be taught Marxism and a prophecy of the wold ending demon that will be unleashed after the gods are forgotten and kings are killed if money still is a focus then.

Build a network of merchant hubs that'll earn sustenance mostly through external trade and fishing, with avoidance of grabs of land if it involved any displacement of locals. While external trade is commercial, internally they should rely on money as little as possible.

The most important milestone is to stall industrial revolution, maintaining a dogma of how bituminous coal (now called Demon Bone) and oil (Demon Blood) are to never to be burned outside of very specific, ritualistic and relatively rare circumstances (metal foundries and chemical extraction) as their use as mere fuel would turn the earth into a actual literal hell (the least gaslighty thing I have to do, tbh).

Grow laterally as much as possible as your local friendly coven of weirdos, emphasize just uprooting the hubs and fleeing if the locals get aggressive.

If things go well, reward myself every now and then by giving whichever ripe local peasantry the thoughts (marxism) and tools (dynamite) to behead their local monarchs.

I don't doubt there's a million things this could turn awry and create a world even worse than ours but hey, you're free to be a fucking coward, I would still give it a shot.