#cellular aging

[medicomunicare]

An UBIquitous Parkin to take a NAP iSINT BAD while OPTN' for cargo hold: but TANK-binding will lead to a mit-o-loss

There are several pathways to induce mitophagy, or the self-degradation of irreversibly damaged cellular mitochondria. The most well-characterized of these depends on proteins called PINK1 and Parkin, two proteins actively involved in the abnormalities of brain cells affected by Parkinson’s disease. Two other proteins, TFEB and HKDC1, play a key role in the maintenance of both mitochondria and…

[scienceswitch]

The Science of Aging: What Happens to Our Bodies As We Get Older?

Aging is a natural and inevitable journey that all living organisms experience. As we progress through the different stages of life, our bodies undergo profound physiological changes. These transformations reflect the complex biological choreography that shapes human development and maturation. Aging is defined as the accumulation of changes over time associated with or responsible for the…

[mindblowingscience]

Genetically engineered mitochondria can convert light energy into chemical energy that cells can use, ultimately extending the life of the roundworm C. elegans, a new study shows.

While the prospect of sunlight-charged cells in humans is more science fiction than science, the research, which takes a page from the field of renewable energy, sheds light on important mechanisms in the aging process.

“We know that mitochondrial dysfunction is a consequence of aging,” says Andrew Wojtovich, associate professor of anesthesiology and perioperative medicine and pharmacology and physiology at the University of Rochester Medical Center, as well as senior author of the study in Nature Aging.

“This study found that simply boosting metabolism using light-powered mitochondria gave laboratory worms longer, healthier lives. These findings and new research tools will enable us to further study mitochondria and identify new ways to treat age-related diseases and age healthier.”

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[landwriter]

🍋 What’s your favorite spicier trope to write?

fruit fic asks!

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[probablyasocialecologist]

Hundreds of millions of people globally lack adequate access to food, but these technologies will not address current inequalities in distribution, which result in high amounts of food waste. This emphasis on speculative technologies is steering attention away from existing, proven approaches to achieving sustainability goals that reduce power asymmetries.

[...]

Dominant firms have less incentive to promote the vision of the founders of cellular agriculture firms and will avoid moving in directions that would undermine their core businesses. Founders of these firms frequently suggest that their products will solve ecological problems and eliminate animal suffering associated with conventional meat production. An agribusiness firm representative, however, explained to academic researchers that investments in the industry were both for growth and ‘defensive’ purposes. Fully replacing industrial livestock and aquaculture production is therefore unlikely, and cellular meat and fish will instead remain expensive niches. A small minority of consumers with ethical objections to conventional animal foods may be willing to pay more for cellular versions, but most consumers will not, even if they have sufficient incomes—especially if they are sceptical of the new technologies behind these products.

Investments in cellular agriculture are focused on business models that implement strong barriers to entry to potential competitors, such as through patents, trade secrets and enacting regulatory barriers, and that promise a high rate of return. This will lead to industries that are geographically centralized and controlled by a very small number of decision-makers, and result in greater vulnerability to disruption. This brittleness was illustrated by outbreaks of COVID-19 in workers in a substantial number of meat processing facilities worldwide, and plant shutdowns affecting as much as a quarter of pork processing in the United States. Other examples of food system shocks include a loss of nearly one-quarter of the world’s pigs due to African swine fever in 2018 and 2019, disruptions from the blockage of the Suez Canal by the ship Ever Given in 2021, and the global impacts of the conflict in Ukraine in 2022.

Cellular agriculture will probably continue to rely on feedstocks from conventional supply chains, such as derivatives of soya, maize, potatoes and wheat. Eat Just, for instance, recently entered into a joint development agreement with the grain/oilseed processor ADM for a growth medium for cellular meat. If these products actually do expand beyond a small niche, demand for monocultural crop production will also rise. The sustainability impacts of these chemical- and fossil-intensive production systems include resource depletion, pollution, land degradation and loss of biodiversity. The social impacts include taxpayer subsidies to lower the costs of production for these feedstocks in some nations (for example, the United States and Brazil) and negative effects on rural communities, due to industrialization, farm consolidation and a declining number of farmers. Unless current technical challenges are overcome, cellular meat will also rely on products of conventional meat processing firms, such as blood serum taken from foetal calves in dairy slaughterhouses.

Products arising from the cellular agriculture industry will continue to promote centre-of-plate dietary patterns. It will not shift eating behaviours towards more diverse and less processed foods, but instead encourage the substitution of conventional meat and fish products, particularly when cellular versions are widely available and/or less expensive. In many markets, even as sales of plant-based meat substitutes increase, meat consumption is not declining. This is an illustration of the ‘displacement paradox’, which results in little suppression of demand for the initial product when a substitute product is available, and is especially likely when the political economic context remains unchanged. One potential outcome, for example, is that cellular agricultural products will be sold as highly processed products (for example, burgers, sausages and nuggets), but not as more technically complex and more expensive full cuts of meat, which would instead continue to be produced primarily by concentrated animal feeding operations.

Cellular meat and fish do not challenge the inequities in global food systems, which produce enough to feed everyone in the world but fail to deliver food where it is most needed. The number of malnourished people has increased in recent years, and an estimated 720 million to 811 million people globally faced hunger in 2020. At the same time, substantial amounts of food are wasted—often deliberately when the practice leads to higher profits. This has not prevented proponents of cellular agriculture from advancing ‘feed the world’ narratives to justify their products as a technological fix, despite doing little to address poverty, social exclusion or other drivers of inequalities of food access.

[deva-arts]

Vincent has dark roots and white hair. Does he dye it?

Nope. His hair just fades in that color past a certain length. If he were to let it all grow out instead of shaving the sides all the time, it would all look white and spiky.

(Similarly, if he buzzed it all off, it would be black.)

[fish-bowl-2]

Thoughts on Ed Edd n Eddy being a Millennium era (1999 - 2000) period piece?

[twoheadedfawnn]

getting older is just like. Oh. You crave a level of closeness and intimacy that is getting harder to find with each passing day

[kevinbutlerweb]

Increase Your Power and Enhance Your Wellness with NAD Infusion

Are you feeling drained pipes and lacking the power to tackle your daily jobs? Have you been looking for a natural way to boost your wellness and general health? Look no more than NAD infusion therapy-- an advanced treatment that can assist increase your power levels and revitalize your body from within.NAD, or Nicotinamide Adenine Dinucleotide, is a coenzyme discovered in every cell of your body that plays an essential function in power manufacturing. As we age, our NAD levels naturally decline, causing reduced power levels and general vitality. NAD mixture therapy functions by directly providing this necessary coenzyme right into your bloodstream, bypassing the digestion system for maximum absorption and effectiveness.One of the key benefits of NAD mixture treatment is its capability to considerably raise energy levels. By renewing your body's NAD shops, you can experience a visible boost in stamina, emphasis, and psychological clearness. Bid farewell to afternoon downturns and hey there to continual energy throughout the day.But the benefits of NAD infusion therapy extend much beyond just enhanced energy levels. This innovative treatment has actually been shown to boost general health and wellness and health in various methods. From sustaining mobile repair work and regeneration to boosting cognitive function and mood stability, NAD mixture therapy supplies a comprehensive method to enhancing your wellness from the within out.Unlike traditional energy-boosting techniques like caffeine or stimulants that offer short-term solutions with prospective negative effects, NAD infusion treatment takes an alternative strategy to wellness. By attending to the source of reduced power levels-- decreasing NAD degrees-- this treatment sustains your body's natural processes for lasting outcomes with no harmful ingredients or chemicals.If you prepare to experience the transformative power of NAD infusion therapy on your own, getting going is simpler than you think. Just arrange an assessment with a certified doctor that focuses on this cutting-edge treatment. During your preliminary visit, you'll discuss your wellness objectives and medical history to identify if NAD mixture treatment is best for you.Once accepted for therapy, you can look forward to kicking back sessions where NAD is provided intravenously under clinical supervision. Numerous people report feeling an instant sense of restoration after their very first session, with advancing advantages experienced over subsequent treatments.In conclusion, if you're seeking to improve your power levels, improve your well-being, and take an aggressive approach to your health, take into consideration integrating NAD infusion therapy into your wellness regimen. With its tested advantages for energy production, total health enhancement, ...

nad infusion

[healthyhabitjournal]

🌟 Dreaming of youth eternal? Discover the natural secret within our DNA! 🧬 Telomere Lengthening is changing the game in anti-aging, offering a path to longevity and vibrant health without the need for expensive treatments. Dive into natural, effective strategies to protect your DNA and unlock a life filled with vitality. Say yes to a healthier, younger you today! #TelomereLengthening #NaturalYouth #HealthyHabitJournal

[medicomunicare]

Invecchiamento del corpo umano: cambiamenti drammatici a due specifiche età, secondo uno studio

Introduzione L’invecchiamento è un processo biologico complesso che interessa ogni aspetto della funzione corporea. Sebbene sia spesso percepito come un processo graduale, recenti studi suggeriscono che il corpo umano potrebbe sperimentare cambiamenti particolarmente drastici in momenti specifici della vita. Un recente studio ha identificato due età chiave in cui si verificano cambiamenti…

[beautyarchive]

Kim Basinger in Cellular (2004).

[jcmarchi]

A new way to see the activity inside a living cell

New Post has been published on https://thedigitalinsider.com/a-new-way-to-see-the-activity-inside-a-living-cell/

A new way to see the activity inside a living cell

Living cells are bombarded with many kinds of incoming molecular signal that influence their behavior. Being able to measure those signals and how cells respond to them through downstream molecular signaling networks could help scientists learn much more about how cells work, including what happens as they age or become diseased.

Right now, this kind of comprehensive study is not possible because current techniques for imaging cells are limited to just a handful of different molecule types within a cell at one time. However, MIT researchers have developed an alternative method that allows them to observe up to seven different molecules at a time, and potentially even more than that.

“There are many examples in biology where an event triggers a long downstream cascade of events, which then causes a specific cellular function,” says Edward Boyden, the Y. Eva Tan Professor in Neurotechnology. “How does that occur? It’s arguably one of the fundamental problems of biology, and so we wondered, could you simply watch it happen?”

The new approach makes use of green or red fluorescent molecules that flicker on and off at different rates. By imaging a cell over several seconds, minutes, or hours, and then extracting each of the fluorescent signals using a computational algorithm, the amount of each target protein can be tracked as it changes over time.

Boyden, who is also a professor of biological engineering and of brain and cognitive sciences at MIT, a Howard Hughes Medical Institute investigator, and a member of MIT’s McGovern Institute for Brain Research and Koch Institute for Integrative Cancer Research, as well as the co-director of the K. Lisa Yang Center for Bionics, is the senior author of the study, which appears today in Cell. MIT postdoc Yong Qian is the lead author of the paper.

Fluorescent signals

Labeling molecules inside cells with fluorescent proteins has allowed researchers to learn a great deal about the functions of many cellular molecules. This type of study is often done with green fluorescent protein (GFP), which was first deployed for imaging in the 1990s. Since then, several fluorescent proteins that glow in other colors have been developed for experimental use.

However, a typical light microscope can only distinguish two or three of these colors, allowing researchers only a tiny glimpse of the overall activity that is happening inside a cell. If they could track a greater number of labeled molecules, researchers could measure a brain cell’s response to different neurotransmitters during learning, for example, or investigate the signals that prompt a cancer cell to metastasize.

“Ideally, you would be able to watch the signals in a cell as they fluctuate in real time, and then you could understand how they relate to each other. That would tell you how the cell computes,” Boyden says. “The problem is that you can’t watch very many things at the same time.”

In 2020, Boyden’s lab developed a way to simultaneously image up to five different molecules within a cell, by targeting glowing reporters to distinct locations inside the cell. This approach, known as “spatial multiplexing,” allows researchers to distinguish signals for different molecules even though they may all be fluorescing the same color.

In the new study, the researchers took a different approach: Instead of distinguishing signals based on their physical location, they created fluorescent signals that vary over time. The technique relies on “switchable fluorophores” — fluorescent proteins that turn on and off at a specific rate. For this study, Boyden and his group members identified four green switchable fluorophores, and then engineered two more, all of which turn on and off at different rates. They also identified two red fluorescent proteins that switch at different rates, and engineered one additional red fluorophore.

Each of these switchable fluorophores can be used to label a different type of molecule within a living cell, such an enzyme, signaling protein, or part of the cell cytoskeleton. After imaging the cell for several minutes, hours, or even days, the researchers use a computational algorithm to pick out the specific signal from each fluorophore, analogous to how the human ear can pick out different frequencies of sound.

“In a symphony orchestra, you have high-pitched instruments, like the flute, and low-pitched instruments, like a tuba. And in the middle are instruments like the trumpet. They all have different sounds, and our ear sorts them out,” Boyden says.

The mathematical technique that the researchers used to analyze the fluorophore signals is known as linear unmixing. This method can extract different fluorophore signals, similar to how the human ear uses a mathematical model known as a Fourier transform to extract different pitches from a piece of music.

Once this analysis is complete, the researchers can see when and where each of the fluorescently labeled molecules were found in the cell during the entire imaging period. The imaging itself can be done with a simple light microscope, with no specialized equipment required.

Biological phenomena

In this study, the researchers demonstrated their approach by labeling six different molecules involved in the cell division cycle, in mammalian cells. This allowed them to identify patterns in how the levels of enzymes called cyclin-dependent kinases change as a cell progresses through the cell cycle.

The researchers also showed that they could label other types of kinases, which are involved in nearly every aspect of cell signaling, as well as cell structures and organelles such as the cytoskeleton and mitochondria. In addition to their experiments using mammalian cells grown in a lab dish, the researchers showed that this technique could work in the brains of zebrafish larvae.

This method could be useful for observing how cells respond to any kind of input, such as nutrients, immune system factors, hormones, or neurotransmitters, according to the researchers. It could also be used to study how cells respond to changes in gene expression or genetic mutations. All of these factors play important roles in biological phenomena such as growth, aging, cancer, neurodegeneration, and memory formation.

“You could consider all of these phenomena to represent a general class of biological problem, where some short-term event — like eating a nutrient, learning something, or getting an infection — generates a long-term change,” Boyden says.

In addition to pursuing those types of studies, Boyden’s lab is also working on expanding the repertoire of switchable fluorophores so that they can study even more signals within a cell. They also hope to adapt the system so that it could be used in mouse models.

The research was funded by an Alana Fellowship, K. Lisa Yang, John Doerr, Jed McCaleb, James Fickel, Ashar Aziz, the K. Lisa Yang and Hock E. Tan Center for Molecular Therapeutics at MIT, the Howard Hughes Medical Institute, and the National Institutes of Health.

[harmeet-saggi]

Unlocking The Fountain Of Youth: 8 Proven Health Measures To Slow Biological Aging

Do you ever find yourself wondering if there's a secret elixir to slow down the relentless march of time and unlock the fountain of youth? In a world where biological aging seems inevitable, the quest for longevity and anti-aging solutions has become more prevalent than ever. The good news is that science and lifestyle choices can play a significant role in slowing down the aging process. In this blog, we will delve into eight proven health measures designed to be your guide on this journey towards the elusive Fountain of Youth. Are you ready to discover the keys to a healthier, more vibrant life?

[milocelium]

its so frazy to hear about the insane amount of medical advaces being made these days knowing full and well none of the things that come from these advances are going to be accessible or affordable for the general population for decades after they actually become available

[axonspro]

The 10 Best Anti-Aging Ingredients for a Youthful Glow 2023

Unlocking the Secrets to Ageless Beauty: Skincare for Every Generation The Top 10 Best Anti-Aging Ingredients for a Youthful Glow 2023 Looking for a youthful glow? These top 10 Best  anti-aging ingredients are the key to fighting signs of aging, including wrinkles, fine lines, and age spots Welcome to the world of ageless beauty, where the secrets to radiant and youthful skin are revealed. In…