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nshtn · 5 months ago

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[ UV Albert Wesker Uroboros & PG67 HCs ]

These take after the knowledge that PG67 contains hastily-added leech genes. This is full of medical jargon related to virology and genetics. It's hard sci-fi styled!

tags: medical:genetic;neurology (hardly);virology;needles (PG67-A/W), cannibalism mention, childhood trauma, body horror, mental decay

Such a far cry from his beginnings... he's truly taken after the man he hates the most.

Unfortunately for Wesker, adding Uroboros in intensely massive quantities to an existing Progenitor-67 infection is a poor choice that makes him spend much of his fight with Chris alternating between pouncing him like a rabid animal and curling like the death throes of a dying spider.

And unfortunately for Chris, Wesker doesn't die when he's left at the volcano to stew in a puddle of himself. Even with the awakened lack of thermophilic qualities as a result of the genetic influence of G, there is enough local flora and fauna to keep him alive... albeit in a subdued state.

Physiological:

Uroboros, combined on the initial foundation of Progenitor 67, takes after Progenitor 67's metabolic inefficiency and drives that far higher than it was ever meant to go in an attempt to sow compatibility.

Due to this, Wesker needs a truly ridiculous amount of calories (~6,000 - ~9,000 kcal/d) to remain fully intelligent.

A lesser amount will generally retain him, though he will experience a plethora of negative symptoms related to starvation (~3,500 - ~5,500 kcal/d).

The very brink of his sanity and humanity will find him lacking if he consumes the average human male's daily caloric intake (~1,800 - ~3,000 kcal/d).

Wesker cannot digest iron bound to salt or any organic chelates except heme (or hemeprotein) as a result of initial Progenitor 67 infection.

Progenitor 67 epigenetically alters his enterocytes. The genes involved with this are the upregulation of HCP1 and the downregulation of DMT1 and, less intensely, Dcytb, and is a result of both Progenitors' own natural leaning and, primarily, the hasty introduction of leech genes when microinjection became available.

This ultimately means that, as time drags on, he begins to find his palate shifts from a lot of power smoothies to meat.

But there is something crucial here: 67% or more of heme iron is lost when you cook meat. That means...

↑ He slowly slips into preferring his meat blue or raw, otherwise he won't be able to properly supplement his need for heme iron.

↑ With the addition of Uroboros, which dethrones and replaces Progenitor, this change persists and couples roughly with his modified caloric needs.

Usually present in brown adipocytes, UCP1 and UCP2 are both overactive as a result of the improper inclusion of Uroboros' gene signalling.

As a result of this, Wesker's natural temperature is hotter than a normal human being's.

He's probably uncomfortably warm to others - almost naturally feverish.

UCP1 and UCP2 cause proton leakage across the mitochondrial membrane - UCP1 being the primary uncoupler regarded in thermogenesis.

↑ As a result of this leak, ATP use is less efficient. This exacerbates his metabolic disorder.

↑ The inclusion of UCP2 upregulation alongside UCP1 was done out of an abundance of caution.

The gluconeogenesis enzyme PEPCK-C, involved in the burning of fat to produce glucose, is overexpressed in dual infection.

While this gives Wesker higher stamina and physical endurance, it comes at the expense of contributing to insulin resistance and is a key player in his bodies' teetering metabolic imbalance.

↑ This is because Uroboros doesn't upregulate and express PEPCK-C in just skeletal muscular cells - it does so where it is already present, too; this is a personal oversight.

↑ PEPCK-M was personally avoided in its' development because it is a popular oncogene.

Uroboros; a monster that eats itself continually without end. It physically presents a sign of Wesker's malingering, endless need to consume across his skin.

Patches of necrotizing, hardening skin and flesh form across his arms and legs in uneven patterns.

Scaly, itchy lesions creep along his cheekbones and the sides of his neck like a corrupted skin flush.

These are a weaker, useless vestigial presentation of the hardening of skin he undergoes when he's being flash-fried by high temperatures.

They're positive for many of the proto-oncogenes related to melanomas and are undoubtedly at least oncogenetic, but aren't strictly cancerous; instead, they're a misguided attempt at defense that vacillates 'on' without facing heat danger.

One of the scars of Wesker's infection and subsequent mutative transformation are hypermelanotic deposits that coat previously-mutated skin in a dark fade.

They start strongest at his fingertips and weaken at the base of his shoulders.

They are also strongest in the center of his chest where his macronuclei is present and taper off approaching his shoulders and abdomen.

His face has some of the same tinting in uneven splotches descending strongest from where he was burned.

Uroboros enhances the strength of many of his bones - more potent the closer to the surface of his body - by fortifying them with calcium and double-thickening them.

As a feature of the beginning stages of Uroboros' starvation, it will begin to leach calcium out of bones and the deposits it creates.

↑ These deposits are not found in the brain or the skull.

When resources are threateningly low, the bones will be stripped for the calcium they uniformly contain, causing him to experience an effect similar to calcium gout / pseudoarthritis, malaise, and brittling.

This leaching undoes itself and becomes re-fortifying under the duress of stress hormones like cholecystokinin and epinephrine. Less specific but still counted in re-fortification is cortisol and norepinephrine.

↑ Re-fortifying can be triggered accidentally through rigorous & sustained physical exercise or copulation.

Epigenetic changes brought on by Progenitor physiologically are stacked upon inappropriately and pseudorandomly by Uroboros like re-patchwork, which leads to a general instability and accidental incorporation of Progenitor's physical defense mechanisms.

This is what ultimately enables him to survive the events of RE5.

Neurological:

Progenitor infection spiraling into his temporal lobes, brain stem, and, minorly, his frontal lobes as years progress are the cause of his irritation and aggression in RE5.

It does this because it has no antimutagenic properties unlike the more developed t-Virus, slowly mutating out of control into a dysfunctional beast as Wesker experiences more and more stress and trauma.

A bit like G in this regard...

His SERT is disrupted by its' presence in the midbrain raphe nuclei along the brain stem.

This causes elevated extracellular serotonin levels initially, followed by receptor downregulation and eventual serotonin deficiency.

The lack of available serotonin leads him to experience, at first, heightened periods of aggression. Later, this becomes mania and even delirium if he forfeits sleep or a PG/67 shot, because...

As time ticks on, his dopamine begins to become dysregulated as well.

This imbalance contributes to mood swings, aggression, and impaired decision-making.

It also leads to a loss of the ability to feel pleasure or joy in things, making him manic and paranoid, taking risks uncharacteristically to feel something, anything.

As Progenitor 67 degrades brain function, particularly areas involved in impulse control and aggression, Wesker experiences the uncontrollable urge to consume.

This leads him to cannibalize interns and people he calculates won't be missed, as well as people who piss him off enough. During this time it does change - and become true - that a misplaced boop! or headpat! might get you killed.

His ego begins to vacillate and strengthen itself in an effort to maintain itself despite his decline. If he can just finish Uroboros, everything will be okay again, he can fix himself...

His brain practically relies on his PG67-A/W dose before he gains Uroboros.

A rapid decline in cognitive and emotional stability when he’s off the dose is present.

It's not unlike sundowning...

You would not want to see his MRIs during this time. They look awful - his brain has lesions and there are parts that are grossly overgrown; there are tiny black specks where Progenitor has gnawed holes in the fabric of him. If he hadn't roped it in, he would probably end up eventually going completely feral from his brain swelling up against the sides of his skull; he'd just become another victim of Cannibal Disease and turn, simply painfully slowly.

Uroboros is not supposed to crawl into the brain. It's supposed to leave it unaffected - but Progenitor having already curdled and spread unchecked into it gives it an opening for opportunistic infection.

It attempts to knit the holes and tamp down overgrown regions, but in doing this, it feeds from a sort of 'genetic template' that restores Wesker's ability to feel and feel greatly. This includes the reactivation (and reanimation) of the greatly disordered regions of his brain responsible for empathy, sleep regulation, attachment, and guilt.

It also cannot perfectly recreate lost tissue or resurrect memories from dead, liquefied tissue, so he retains some of his symptoms, like mood swings.

Rage becomes consuming, hunger becomes voracious, and guilt becomes haunting; he is plagued with an unfortunate (to him) tendency to consider others.

He finds it a prying weakness, but he can no longer tamp it down into nonexistence as he did; he is, essentially, thermally reduced to his Arklay days in behavior. He’s still intelligent and cunning, but he must now wrestle with intense emotional responses that don’t align with his goals at all...

Guilt and empathy are so foreign to him they are nearly out-of-body; he views them clinically and tries to rationalize them away, but his inability becomes the stake that impales him and imparts a malingering sense of conflict.

...and he must take a good, hard, long look at his goals and how far they've diverted from their initial precedence.

... what is he now? What use does he serve in this world - to what master does he heel, clearly dethroned from his position? These questions and more are things he asks himself now.

Is he doomed to roam aimlessly without purpose until he perishes?

#albert wesker headcanons #albert wesker #resident evil #resident evil rp #hard sci fi as in I tried to make it come off as highly realistic but its probably still running along the edges of sci-fant.#this guy is more aimed towards my roleplaying BUT I CAN WRITE FOR HIM TOO!!#the irritation and aggression paper is literally 107 people that's... not nearly high enough #we copped 1 wikipedia article for raphe nuclei #i couldnt support his cannibalism with the movies but in the movies just trust me bro he ate someone once #ego vacillation source: ME and my DARK MIND /j #/dev/writing/

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nenoname · 12 days ago

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How would you have planned an arc for Wendy in the show, since the writers claimed they never managed to crack her? I mean, we see how they managed to do for Pacifica and Soos in like two or so episodes. Why can't they do so for Wendy?

Btw it slightly pains me to say it a little as a dipcifica shipper, but if they claim there's no space for Wendy episodes, then I would drop the Pacifica episodes. She didn't end up contributing much to the overall plot.

unfortunately i think we might have to turn the mystery shack trio into the daddy issues trio because that really is how wendy's general issues was kinda heading in my opinion

her struggling with a controlling but still loving dad (who also has severe memory gaps from the blindeye cult, considering he built ford's house and actually knew ford, along with likely encountering anomalies constantly) and her acting out due to pent up stress and even more pent up grief from losing her mum.... her blindeye line about her putting on a facade really is super compelling to me and it (along with her really wanting to leave town when she gets the chance) gives her another connection to stan which i think they both really needed

while i do constantly go on about there needed to be a story with dipper as a supportive friend instead of it always being vice versa, i would also love one about her relationships with soos and mabel cos it's genuinely really cute, heck maybe expand on her childhood friendship with tambry a bit. there's also the implication she might've been bullied as a kid for being super tall too

i of course get why the writers wanted to flesh pacifica out but it really did take up the episodes/comic story/website story that wendy could've gotten and honestly? i would've been satisfied with golf war as her settling as a tentative friend (not like the nw ep or website+comic story got to properly resolve her being stuck with extremely abusive parents and being a guilt ridden descendant of evil rich fuckers.....)

the general idea of her getting to bond with susan post-series is something i'm way more interested in than her just being part of the mystery shack family because it gets to flesh the both of them out more too (and even with weirdmageddon her being able to develop a bond with candy and grenda might've been also fun)

paz being the only "rival" character who got s2 screentime also stands out! the writers deliberately had little gideon screentime since he was the main s1 villain but it makes his change of heart pretty abrupt (and i'm salty at the lack of him idolising ford cos that is a hilarious dynamic), and robbie's ep literally didn't address the issues of who he is as a person-- aka his extreme insecurities and not respecting wendy at all so shoving him with another girl ain't fixing any problems!!! you can't "oh this is actually true love, this love potion is fine" me hirsch!!!!!

and in the end paz's role in weirdmageddon 3 ends up coming off extremely forced and honestly makes me pity her cos like??? she doesn't want to be there??? what in-universe reason is she on ford's rescue team???? at least stan has a reason to protect the rest of his family!!!! but she's the "llama" i guess even tho that role could've also gone to freaking wax larry king's head or literally anyone who happened to wear that sweater (and yes the northwest ep has a portrait of a llama in the background and in the end the writers wanted the zodiac to have that theme of friends, family, rivals and enemies coming together but urgh. it feels so clunky, might as well have her get captured like the other rivals to give her a reason to be in the fearamid)

(but yeah, i am kinda biased from years of folks excluding soos+wendy+grenda+candy from group arts too lmao but i don't mind if paz is included as long as they at least include the others instead of pretending the trio of dipper+paz+mabel is the only one that exists)

#i was initially indifferent to d/ipcifica but it being literally everywhere really irritated me over the years #and honestly paz getting 'love interest-ed but look!!! it's like wendy but better cos its requited teehee!!!'#isn't fate i wish on her when we see how wendy turned out outside the role of being dipper's crush 😔#(and characters like melody and tambry being just 'this guy's love interest' is meh to me too so if we ever get some more post series stuf #im begging for melody to get some more character and heck even bond with wendy)#anyway this is me lamenting about the main character of the show kinda getting in the way of other character dynamics lmao #sorry dip i still love ya kid #but also treat the women in this series better dangit!!!#i hope d/ipcifica get together + break up amicably + become friends!!!!#neno blabs about ships #stan @ wendy: wow she was like me..... if i was a girl and popular and actually liked by my family and had other friends #'so not really like me at all.'#in a 'this show was made 5 years ago' world they could've bonded over being bisexuals with terrible love lives lmao #with paz being a not-ovw gamer it would've been fun for her to help take charge of shacktron's orders #cos most of the main fighters leaving them to freaking fight bill themselves is odd.....#grenda and candy doing all the work tsk

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