#asiatic clinical research

[clivaldatabase]

Clinical Chemists in Early Phase and Bioequivalence Studies

The role of clinical chemists in early-phase clinical trials and bioequivalence studies is pivotal. Their expertise in analyzing biological samples, interpreting complex data, and ensuring adherence to regulatory standards is critical to the success of drug development processes. This article explores their contributions, emphasizing their integration with clinical trial data solutions, the role of clinical trial research organizations, and their importance in advancing orphan drug databases, particularly in countries like India.

[starfleetisapromise]

Some thoughts on Picard Season 2 and why it's unpopular.

So I had a bit of an epiphany yesterday. I'm rewatching Picard Season 2 in preparation for a discussion about it with a colleague next week and I was constantly reminded that a lot of fans are very visceral in their dislike of this season.

To be honest, there are parts of it that I don't like. I think the whole Soong/Kore story was a totally unnecessary distraction and was only done, once again to shoehorn in Brent Spiner and the Picard/Data relationship - which I never found compelling in the first place. But that's just me.

However, I realized that Picard Season 2 does something that no other season (or show) of Star Trek does, it centers the entire narrative on humanity. By making the protagonists AND the antagonists humans, there is no subtle (or not so subtle) use of alienation to map contemporary adversaries or conflicts onto the Federation's adversaries. This is important, because, as I have argued in a multitude of research papers, Star Trek is very, very guilty of framing future conflicts through the lens of contemporary adversaries. This was done very explicitly in TOS - both Roddenberry and Coon overtly asked for the Klingons to be modeled on an "Asiatic Communist" trope. Communism was again the enemy in TNG, through the medium of the Borg and "assimilation" and loss of individuality. DS9 has its Cardassian "Nazis"; Voyager and Enterprise the chaotic post-Cold War existential threat of non-state actors and by the time we get to Discovery, the Klingons have been recast as Jihadist extremists.

The fundamental problem with this is that no matter how much Star Trek might talk about the Federation being a "future better us"; by casting recognizable real world adversaries as the Federation's foes, it automatically casts the contemporary US as the Federation (that's just how TV works, especially through the manichean lens of US culture).

So, if you don't want to think too hard about the ways in which the US interacts with the world. If you don't want to think too hard about American exceptionalism and Neo-imperialism and the misuse of force (and capital) without and within the US. If you cloak it all in the surface progressiveness of visible diversity - and I'm not claiming that diversity and representation isn't important, of course it is, but diversity does not equal progressive politics - then you can happily watch Star Trek without ever having to grapple with the uglier parts of the American experience. If we are the Federation, and clearly we must be because the Federation's foes are recognizably our foes, then we are already the galaxy's "good guys"; the Federation is just a future extension of the American now.

Season 2 of Picard blows that all apart. The bad guys are the Confederation and, by going back to the 21st century and exposing the roots of the Confederation in all the ugly, racist, greedy, unequal, venal, corrupt layers of 21st century America, the Confederation is a direct consequence of that present (our present) being allowed to play out into the future. We are the enemy in the 21st century and we become the enemy in the 24th century.

And the show pulls absolutely no punches. We get ICE brutalizing detainees and explicit discussions of people being disappeared because they are dehumanized as "non-people". Homeless encampments and immigrant clinics amid glittering towers and sumptuous parties. We get quips about the ridiculousness of pledging allegiance to a flag (thank you Ríos) and monologues about exchanging white hoods for suits (thank you Guinan). Some of the despair is directed to the behaviors of everyone on the planet - climate change - but the vast majority of the political commentary is explicitly about the contemporary US.

Not only that but it's done by a diverse cast that speaks Spanish, and is brown and queer and female and empowered (thank you Queen Agnes) and where the only white men are aging and feeble.

It is (the wandering Soong/Kore storyline notwithstanding) fucking brilliant television and it's the first time that Star Trek is ever explicitly - textually AND subtextually - progressive. There is no ability for the audience to elide the message by hiding in the fiction that we are the Federation and THEY are the bad guys (the Klingons, the Borg, the Romulans, the Breen, the Cardassians).

So no, let's get rid of the bullshit that people don't like Picard Season 2 because of "the writing", the writers room for Seasons 2 and 3 is almost identical (Matalas, Appel, Monfette, Maggs and Okomura) and the writing for both seasons was taking place almost at the same time.

Whether it's subconscious or not, the disproportionate degree of hate leveled at Season 2 (often by the same fans that love season 3 for it's "great writing" and overt nostalgia) exists because the storytelling in Season 2 leaves fans no place to hide. Because for the first time Star Trek really dives into the core of science fiction, which, as many, many sci-fi writers have explained (Margaret Atwood most recently), is not to predict the future but to critique the present.

I may come back and edit or extend this later, but right now I'm going to leave it as is and post.

Edited to clarify that you can hate Season 2 for any reason you want to, personal taste is just that, personal - but the (for the first time) explicit social commentary cannot be divorced from the unusual levels of vitriol hurled at this season by a substantial group of very vocal fans.

[digitalmarketing923]

Clinical Trials Being Taken Up In India For Cholera Vaccines

Cholera is a bacterial infection that causes diarrhea, which kills the patients within hours, if left untreated. If patients are diagnosed in time, and treated with antibiotics and other measures at an early stage, they can recover and get back to their normal lives, but if not, they may have to lose their life! Cholera infects approximately 2.8 million people, causing 95,000 deaths every year! In 2018, there was a global demand for around 100 million doses of cholera vaccine, but the supply was only somewhere around 20 million; so you can imagine the sad face of the outbreak!

Today, the world relies only on two suppliers for cholera vaccines – one from South Korea, and the other from India; but, the global demand for cholera vaccines is higher than the supply. This is why large-scale clinical trials are being planned to be conducted, and a Swedish-designed cholera vaccine is to be commercialized to help fight persistent outbreaks of cholera in India and abroad.

The Hilleman-Bharat pact

It is the Hyderabad-based Bharat Biotech that signed a pact with the New Delhi-based Hilleman Laboratories to speed up the development and clinical trials. Also, the manufacture of the new oral cholera vaccine needs to be accelerated for the drug to be supplied to low and middle income countries. This collaboration of Bharat Biotech and Hilleman Laboratories has been mainly done to address the global shortage of cholera vaccines, in the midst of the persistence of outbreaks in several states across India and Africa.

What is the pact about?

Under the pact, Hilleman laboratories have licensed to Bharat Biotech the vaccine designed by scientists at the University of Gothenburg, Sweden. The vaccine’s safety and capacity to produce an immune response to cholera has already been established by Hilleman laboratories through limited Phase-1 and Phase-2 clinical trials in Bangladesh. Bharat Biotech, thus, has to conduct larger Phase-3 trials and scale up the vaccine production process for commercialization, while also seeking a pre-qualification certification from the World Health Organization, to enable it to supply the vaccine through global funding agencies. The entire process may take somewhere around three years, but the capacity to deliver 50 million doses every year will resolve the uncertainty over supply.

Cholera widespread in India

In India, the highest risk of cholera is in Bengal. In fact, Ancient Asiatic cholera strains have also thrived in the Ganges delta, making Bengal very unsurprisingly the most highly affected state. In fact, almost 50% of cholera cases seen in India every year have been in Bengal. Next in line come Karnataka, Gujarat, Maharashtra, Punjab, Odissa, and Assam. With a goal to produce an affordable vaccine that improves access to millions of cholera patients not only in India, but worldwide too, the vaccine that is being tested could be a key tool in the Narendra Modi government’s Swachh Bharat Abhiyaan campaign, which seeks to improve the levels of sanitation, and the access to clean drinking water.

Get yourself the best quality online clinical research training from Avigna Clinical Research Institute to establish a career in the clinical research industry, so that even you can put in your efforts and inputs to help your country, and the entire world, fight many such conditions like the life-threatening cholera! And, if you are worried about the associated expenses, worry not, the Indian Government has launched a scheme called SPARC, wherein the government will fund interested clinical research students and give them a chance to work in at least 28 global universities!

[siglerprescriptiondrugcards]

Gotu Kola

Scientific Names: Centella asiatica, (synonym Hydrocotyle asiatica), C. coriacea Other Common Names: Indian pennywort or water navelwort, talepetrako, marsh penny Overall Safety: 😐

Therapeutic Efficacy and Considerations:

Flight Microangiopathy: 😐 One trial has demonstrated improvement in ankle edema at various flight durations. More research is warranted, but the current evidence is not sufficient to support a recommendation for this indication.

Venous Hypertension: 😐 Five placebo-controlled trials have all demonstrated decreased edema and symptoms, although patients with mild symptoms did not seem to experience much clinical benefit. More information is needed both on long-term safety and extent of efficacy before a general recommendation can be made. Gota kola may be a possible treatment option in patients with severe edema who have failed or refuse other available therapies. Dose: 30-60 mg triterpenes three times a day.

Sedation/Anxiety: 🙁 Only one preliminary study relating to anxiety has been conducted. It found a reduction in startle response in healthy subjects. Use for sedative or anxiolytic effects is not recommended at this time.

Sedation/Anxiety: 🙁 Only one preliminary study relating to anxiety has been conducted. It found a reduction in startle response in healthy subjects. Use for sedative or anxiolytic effects is not recommended at this time.

Chemistry/Pharmacology: The primary ingredients are triterpenoid saponins, madecassoside, and asiaticoside, as well as asiatic and madecassic acid. Madecassoside and asiaticoside seems to be responsible for decreasing venous pressure and improvements in microcirculation in venous insufficiency. These also have effects in wound healing by decreasing inflammation and glycosaminoglycan and collagen synthesis. Topical application of extracts increases collagen synthesis, intracellular glycoproteins, and mitotic activity and enlarges keratohyalin granules in scar tissue to reduce their appearance. Some antioxidant effects might be responsible for protection of the gastric mucosal lining observed in animal studies. Potential sedative and analgesic effects could be associated with GABA-B receptor binding or increases in GABA. Two other terpenoid constituents, brahmoside and brahminoside, may also be involved with these activities.

Drug Interactions: May have additive effects with sedative drugs; high doses may interfere with the activity of antidiabetic agents, hypolipidemics, and antihypertensive drugs.

Contraindications/Precautions: Pregnancy and lactation (due to lack of information on effects); may elevate blood glucose, triglycerides, and cholesterol levels; may have cross-sensitivity in patients who are allergic to members of the celery family.

Adverse Effects: Hypercholesterolemia, hypertension, hyperglycemia, sedation, GI upset, photosensitivity, hepatotoxicity. Topically: burning sensation, contact dermatitis, or pruritus.

[esmerodo]

SAILOR MOON GEMSTONES & MINERALS: GARNET (FOR SAILOR PLUTO DAY) 

 By: ~ Mamoru Chiba 

A belated Happy Birthday to Setsuna! Born on Sunday, October 29th. What year? WHO REALLY KNOWS? ;-) This is a post I did Sunday for the FB Page Sailor Moon: The Mooniverse, where I am their Admin Mamoru Chiba 🎩🌹🌙🌏

I have a Birthstones & Horoscope Post for all of the Senshi plus Tuxedo Mask. Would you like to see them here on Tumblr? Let me know in the replies! --Esmerodo. 

=========================@ 

SCORPIO: Setsuna was born on October 29th, under the Zodiac sign of Scorpio. The Ruling Body for people born on this date is the Planet Pluto, representing desire, transformation and expansion. (Moonies, please note: anyone who remarks here that Pluto isn’t a planet anymore, gets bopped on the head with the Time Rod and sent to a time in history that you will NOT like! You have been warned!) 

NAOKO-SENSEI’S TRAINING IN MINERALS & GEMSTONES: The reason we do this feature is because Naoko Takeuchi named most of her villain characters after a gemstone or mineral and has each of the Senshi themed around certain symbolic gemstones. Where they are known I’ve also listed each Senshi’s Zodiac gemstone and Talismanic gemstone too. I have added the horoscope for the day each Senshi was born. Takeuchi-sensei was born in Kofu, Yamanashi Prefecture, the historically famous city of artisan gems carving and distributing in Japan. To this day, the Yamanashi Gem Museum displays gems, precious stones, and large quartz crystals collected from Japan and around the world. Naoko also pursued her interests by joining an earth sciences club in high school. 

 In university, Naoko Takeuchi studied chemistry in preparation to become a pharmacist and clinical research technician, which led to a by-the-book “mineral knowledge” being persistent throughout her work, and she got to know all the lore behind a large variety of minerals and gemstones. For instance, Mimete isn’t a gemstone; she is a mineral, mimetite, and her dress and tights are EXACTLY the same golden yellow colour of mimetite. Naoko coloured her illustrations VERY carefully! Naoko-sensei had promised her Dad, if this manga drawing idea didn’t work out, she could always fall back on working in a drug store! :-)And as you will see, the mineral/gemstone knowledge did NOT go to waste, when that Sailor Moon manga thing worked out in a big way! 

SECRETIVE, PASSIONATE & IMPULSIVE: People born on this date are passionate, secretive and impulsive, masking their strong willed, ambitious nature under a deceptive cool calm reserve. Because people born on this day like to keep others in the dark about their true thoughts and intentions, they call a person born on this date the "Chess Master." They are very attractive to everyone they meet. 

A WOMAN OF MYSTERY: We can easily imagine the Senshi of Time, with her knowledge of all the ages, keeping secret all the knowledge she has acquired about the past, present and future, quietly observing, making her plans and directing the other Senshi masterfully. You better let this Scorpio be in charge, or she will be annoyed! Independent and innovative, bursting with ideas and energy, the Scorpio woman is formidable and awe inspiring, but we never know what she’s thinking. Setsuna is an ageless woman of mystery. Well, maybe one thing we DO know: People born on this date are drawn to people born between July 23 and August 22, the sign of Leo. Hmmm. That’s Mamoru’s Zodiac sign and...AHEM, let’s not go there. :P 

SOLITARY SCORPIO: Sailor Pluto is ideally suited to her role as the eternally solitary Senshi, because people born on this date tend to give all their energy to achieving their professional goals while sometimes forgetting about their personal lives, favouring unusual careers and often ending up working for themselves. They spend money casually but aren’t interested in money for its own sake. We all have noticed that Setsuna is wise, gentle, affectionate and considerate, especially with the youngest Senshi, Chibi Moon/Small Lady, and Sailor Saturn/Hotaru. These admirable qualities will only get stronger as she gets older. 

PLUTO’S SCORPIO BIRTHSTONE, THE GARNET: The Garnet, the talisman in Sailor Pluto’s Time Rod, is most closely associated with our most mysterious of the Senshi. Garnet is the Planetary Gemstone associated with Pluto, the ruling planet of Scorpio, and is hence the planetary stone for Scorpio. 

SCORPIO'S LUCKY COLOURS: Deep red, the colour of garnet is Scorpio’s lucky colour, along with violet, scarlet and carmine. Perhaps this is why Setsuna usually wears a violet suit with a red bow in the 90’s anime! Garnet, the Scorpio birthstone occurs mostly in deep red, a passionate sensual Scorpio colour. The Scorpio gemstone is believed to enhance healing and relieve depression. [REFERENCES: http://birthdaypersonality.org/october-29-zodiac-birthday-horoscope/ http://www.zodiac-signs.co/months/october-29-zodiac-sign-scorpio.html http://kamayojewelry.com/zodiac-signs-birthstones/scorpio-birth-stone/ http://entertainment.howstuffworks.com/horoscopes-astrology/october-29-birthday-astrology.htm http://www.thehoroscope.co/zodiac-signs/october-29-zodiac-scorpio.html ] 

GARNET ROD: According to wikimoon.org, the Garnet Rod was an item carried by Sailor Pluto. She primarily used the Garnet Rod to perform the attack Dead Scream, but it also functioned as a key of sorts to the Space-Time Door. Her talisman, the Garnet Orb, sat atop this Rod. Sailor Pluto still had access to the Garnet Rod even in her civilian form. In the manga, it protected her from the Tellun she was analyzing, and in the anime, she used it to show the Inner Senshi a vision of the Silence. 

GARNET, THE OLDEST GEMSTONE OF ALL: So why did Naoko Takeuchi choose a Garnet for the Time Rod? Sailor Moon Fans, she chose it because garnets have a history the world over, as old as Time itself. Sailor Moon’s creator really, really knows her gemstones and minerals and has done her homework on what they mean to the Sailor Moon story. Garnets have as long a history as both a gemstone and a talisman as there were humans on Earth, from what we can determine. According to crystalvaults.com, not only was Garnet prized as an ornamental jewel, but its strong curative powers and protective energies made it invaluable. 

GARNET=POMEGRANATE: Garnet comes from the Latin name “Granatum”, meaning pomegranate, because granular varieties of Garnet look a lot like pomegranate seeds. Wonder if Setsuna likes drinking POM Wonderful pomegranate juice for its antioxidant qualities, to keep her ageless? If so, she could, in theory, drink a pint of pomegranate juice from an ancient Roman hollowed out cup made from garnet! The Roman historian Pliny wrote that the large dull-colored "Carbunculus of India" (a type of Garnet) used to be hollowed out into vessels, which would hold as much as a pint. 

THE HISTORY OF GARNETS: Not only were Garnets popular in ancient Greek and Roman civilizations, but Garnets were used in Egypt more than 5000 years ago, in Sumeria around 2100 B.C., in Sweden between 1000 and 2000 B.C. and in the former Czechoslovakia as far back as the Bronze Age. 

GARNETS AS A TALISMAN: As a talisman, Garnet was used as a sacred stone by the Native American Indians, the South American Indians, the Aztecs, the African tribal elders, and the Mayans. Garnet acts with speed to expand one's awareness, due to the flash of lightning contained within, and enhances one's internal fire to bring creative powers to implementation. As a Warrior's Stone, Garnet served as a talisman in the Crusades for both the Christians and their Muslim enemies. Garnets also had religious significance in Biblical times: According to the Talmud, the only light on Noah's ark was provided by a large Garnet. 

GARNETS AS A BLOOD RED WEAPON: The red Garnet, which used to be called a carbuncle, is the colour of blood. So some Asiatic tribes believed that this blood red stone would not only protect you from being wounded, but it would be more deadly as a weapon in a slingshot or as a bullet. In 1892 on the Kashmir frontier, the rebellious Hanzas used Garnet bullets to fire on British troops. No, I don’t know whether Garnet bullets are more effective than lead bullets! But they certainly would be more expensive ammunition! 

GARNETS AS GEMSTONES & ITS PROPERTIES: Garnet is a powerful energizing and regenerative stone. It balances, strengthens and protects. According to crystalcure.com, Garnet is known as the stone for a successful business. Maybe this is why Setsuna never seems to lack for funds and when she moved in with Haruka, Michiru, and Hotaru, they seemed to live in great prosperity! Not to mention, her timeless Garnet talisman Rod was the key to the Time Gates, which allowed Sailor Pluto to go back in time and collect priceless items that she could bring back to the modern world to sell. Some day I hope to see Setsuna’s outstanding awesome collection on the Antiques Roadshow! 

SUCCESS IN BUSINESS & PROTECTION ON JOURNEYS: If your business is not as good as it should be, just put 3 or more garnets on your desk. It is believed that if a garnet is put under a pillow it will cure depression. Garnets can be used to make a person popular and have self-esteem when worn as jewellery. It helps protect one on trips (any trips, not just through Sailor Pluto’s Time Gates!). Garnets bring constancy to friendships.

BLOOD RED, BURNING COAL: Garnets help aid circulation and all blood related issues. Garnet does come in colours other than blood red, but in its most common form, it is called Almandine, formerly known as a “carbuncle” (though originally, almost any red gemstone was known by this name). The term "carbuncle" is derived from the Latin meaning "live coal" or burning charcoal. Almandine is a corruption of Alabanda, a region in Asia Minor where these stones were cut in ancient times. 

ANCIENT JEWELLERY (WIKIPEDIA): Red garnets were the most commonly used gemstones in the Late Antique Roman world, and the Migration Period art of the "barbarian" peoples who took over the territory of the Western Roman Empire. They were especially used inlaid in gold cells in the cloisonné technique, a style often just called garnet cloisonné, found from Anglo-Saxon England, as at Sutton Hoo, to the Black Sea. Pure crystals of garnet are still used as gemstones. 

THE COLOURS OF GARNET: Garnet gemstone varieties occur in shades of green, red, yellow, and orange. The next most common colour after red is emerald green, the colour of Sailor Pluto’s hair. There are two well known varieties of emerald green Garnets: Tsavorite and Demantoid, which is the most valuable Garnet of them all. So is Setsuna’s hair supposed to resemble Tsavorite or Demantoid? We’ll have to ask Naoko-sensei that question! Garnet is also the birthstone for the month of January and the State Gemstone for New York State. The Star Garnet (Garnet with rutile asterisms) is the State Gemstone of Idaho. 

OTHER BIRTHSTONES: PLANETARY GEMSTONE FOR SCORPIO: Ruby Ruby is the other Planetary Gemstone associated with Pluto and Scorpio. For more information on Rubies, please see Sailor Mars’ Gemstone Page. Other Scorpio Zodiac Gemstones are Apache Tear, Aquamarine, Beryl, Coral, and Obsidian. Before Pluto was discovered, Mars was considered to be the ruling planet for the Zodiac sign of Scorpio. The red gemstones of Mars such as Ruby, Red Coral and Poppy Jasper are still considered to be the most auspicious colours for Scorpios to wear. 

TALISMANIC GEMSTONE: Amethyst FOR GRIEF, LOSS & DISPELLING NEGATIVE EMOTIONS: The Talismanic Birthstone associated with Scorpio is the Amethyst. Amethyst imparts soberness, spiritual insight, calm, balance, peace and inner strength to the wearer, helping him or her to deal with personal losses and grief. Apache Tear and Obsidian, like other black gemstones are best for dispelling negative emotions and grief. Given Sailor Pluto’s extremely long life through the ages as the daughter of Chronos and Guardian of the Time Gates, she has experienced and will experience the grief of losing those she loves many times. Setsuna will need whatever strength Amethyst, Apache Tear and Obsidian can give her to move on and be the wise, spiritual and calm Senshi who so many rely on. [http://kamayojewelry.com/zodiac-signs-birthstones/scorpio-birth-stone/] 

FAN ART: Eternal Sailor Pluto by nuxi-chan with her green garnet hair, holding aloft her blood red Garnet rod with its talisman gemstone, eternal as time itself! 

GEMSTONE PHOTOS: Top Left: Teardrop shaped African Demantoid, from swalagemtraders. Top Centre: Rough mineral Garnet fromprettyrock.com Top Right: Russian Demantoid Diamond Ring Bottom Left: TMC Pakistan Tsavorite Bottom Centre: From jewelocean uk: garnet gemstone engagement ring on silver Bottom Right: Heart shaped Tsavorite from uppergems.com 

 Many happy returns, Setsuna, from admin ~ Mamoru Chiba

[howwelldoyouknowyourmoon]

Asian ginseng – there is currently no conclusive evidence supporting any health benefits

Was Sun Myung Moon’s “Il Hwa ginseng providence” another big scam? It earned $billions for Moon, but may not have given customers any health benefits. 

National Center for Complementary and Integrative Health

https://nccih.nih.gov/health/asianginseng/ataglance.htm

Asian Ginseng

This fact sheet provides basic information about Asian ginseng—common names, usefulness and safety, and resources for more information.

Common Names:  Asian ginseng, Chinese ginseng, Korean ginseng, Asiatic ginseng, Oriental ginseng

Latin Name: Panax ginseng

Background: Asian ginseng is native to the Far East, including China and Korea, and has been used for health-related purposes for at least 2,000 years. Asian ginseng is one of several types of ginseng (another is American ginseng, Panax quinquefolius). The terms red ginseng and white ginseng refer to Asian ginseng roots prepared in two different ways. 

The herb called Siberian ginseng or eleuthero (Eleutherococcus senticosus) is not related to true ginseng.

The root of Asian ginseng contains chemical components called ginsenosides (or panaxosides) that are thought to contribute to the herb’s claimed health-related properties.

How Much Do We Know?

There have been many studies of Asian ginseng in people, but few have been high quality. Therefore, our understanding of Asian ginseng’s health effects is limited.

What Have We Learned? There’s currently no conclusive evidence supporting any health benefits of Asian ginseng.

What Do We Know About Safety?

Short-term use of Asian ginseng in recommended amounts appears to be safe for most people. However, questions have been raised about its long-term safety, and some experts recommend against its use by infants, children, and women who are pregnant or breastfeeding.

The most common side effects of ginseng are headaches, sleep problems, and digestive problems.

Some evidence suggests that Asian ginseng might affect blood sugar and blood pressure. If you have diabetes or high blood pressure, consult your health care provider before using Asian ginseng.

The risk of interactions between ginseng and medications is believed to be low, but there are uncertainties about whether ginseng might interact with certain medications, such as the anticoagulant (blood thinner) warfarin (Coumadin). If you’re taking medication, consult your health care provider before using Asian ginseng.

Keep in Mind

Tell all your health care providers about any complementary or integrative health approaches you use. Give them a full picture of what you do to manage your health. This will help ensure coordinated and safe care.

The NCCIH Clearinghouse provides information on NCCIH and complementary and integrative health approaches, including publications and searches of Federal databases of scientific and medical literature.

Key References

Geng J, Dong J, Ni H, et al. Ginseng for cognition. Cochrane Database of Systematic Reviews. 2010;(12):CD007769. Accessed at http://www.thecochranelibrary.com(link is external) on March 31, 2015.

Ginseng, panax. Natural Medicines Web site. Accessed at naturalmedicines.therapeuticresearch.com/ on March 30, 2015. [Database subscription].

Ginseng root. In: Blumenthal M, Goldberg A, Brinckmann J, eds. Herbal Medicine: Expanded Commission E Monographs. Newton, MA: Integrative Medicine Communications; 2000:170-177.

Gurley BJ, Fifer EK, Gardner Z. Pharmacokinetic herb-drug interactions (part 2): drug interactions involving popular botanical dietary supplements and their clinical relevance. Planta Medica. 2012;78(13):1490-1514.

Jia L, Soldati, F. Ginseng, Asian. In: Coates PM, Betz JM, Blackman MR, et al., eds. Encyclopedia of Dietary Supplements. 2nd ed. New York, NY: Informa Healthcare; 2010:348-362.

Karmazyn M, Moey M, Gan XT. Therapeutic potential of ginseng in the management of cardiovascular disorders. Drugs. 2011;71(15):1989-2008.

Shergis JL, Zhang AL, Zhou W, et al. Panax ginseng in randomised controlled trials: a systematic review. Phytotherapy Research. 2013;27(7):949-965.

                                              人参濃縮液        LINK

A huge FFWPU scam in Japan is revealed

Ginseng on wikipedia – notes

[iasshikshalove]

Daily Current Affairs 25th April 2020

FIRST PLASMA THERAPY TO BEGIN IN KARNATAKA TODAYConvalescent Plasma Therapy:

In order to combat the COVID-19 pandemic, researchers and scientists are working tirelessly to develop a proper treatment for patients infected with the novel Coronavirus.

Amid testing the already existing antiviral drugs and new ones, the researchers have come across the Convalescent Plasma Therapy, which could be a potential treatment for the virus.

Several countries including China and the US have already started the clinical trials of the Convalescent Plasma Therapy due to the absence of a coronavirus-specific treatment to cure the infected patients.

The Convalescent plasma therapy was first used during the 1918 Spanish Influenza outbreak.

The approach was used recently during the outbreak of SARS, MERS and Ebola viruses.

What is Convalescent plasma therapy and how does it work to fight COVID-19?

Convalescent Plasma Therapy, also known as passive antibody therapy, provides a person with already developed antibodies to fight a virus.

Under the Plasma Therapy, the COVID-19 patients will be infused with an antibody-rich blood plasma of the people who have recovered from the novel Coronavirus.

The Convalescent Plasma Therapy is based on the antibodies and proteins developed by the immune system that protects the body from any potential harm.  

When any virus attacks the body, the immune system produces antibodies to attack the virus. These antibodies are produced by immune cells ‘B lymphocytes’, found in blood plasma.

The person who recovers from a virus has developed antibodies that stay in blood to fight the same virus, if it returns.

And if these antibodies are infused into other person infected with the same virus, they recognise the virus and attack it. However, these antibodies stay for short period in other person’s blood.

Some antibodies neutralize the virus and some work by mobilizing the immune cells to combat a disease.

Is the Convalescent Plasma Therapy a success in treating COVID-19 patients?

It is not yet clear that which mechanism will be followed by COVID-19 antibodies to fight off the disease.

However, it is expected that the infusion of blood plasma will boost the passive immunity until the patient develops his or her own targeted ability to combat the virus.

Results of Convalescent plasma therapy trials conducted in China:

As per the tests conducted on a few patients of Coronavirus in China, the therapy came out as a promising option for severe cases.

The tests were conducted in 10 patients who were given a single dose of blood plasma of recovered patients.

The results showed that the coronavirus disappeared from patients’ blood in 7 days; lung lesions improved within 7 days and clinical symptoms improved significantly within 3 days.

Why in News?

The first plasma therapy in Karnataka for COVID-19 patients will begin on Saturday, and will be carried out jointly by the Bangalore Medical College and Research Institute (BMCRI) and the HCG Hospital.

Jawaid Akthar, Additional Chief Secretary (Health and Family Welfare), said that many people who have recovered from the disease have come forward to donate their blood.

We will begin by collecting the samples of two or three people who have recovered.

Those who have other co-morbidities cannot participate in this process.

R. Jayanthi, Dean and Director of BMCRI, said that a mass appeal will be sent to patients who have recovered from COVID-19 to come forward and donate.

“Those who are discharged and are in the period of 14 to 28 days can come forward to donate.”

The trial will test the efficacy of plasma therapy which uses antibodies of cured patients to treat critically ill COVID-19 cases.

NO PLAN TO EASE FISCAL DEFICIT TARGETSWhat is Fiscal Deficit?

Fiscal deficit is the distinction between the government’s total expend and its total receipts and this excludes borrowing.

Gross fiscal deficit = Total expenditure – (Revenue receipts + Non-debt creating capital receipts)

The fiscal deficit has to be financed by borrowing. Hence, it manifests the total borrowing necessities of the government from all the possible sources.

Gross fiscal deficit = Net borrowing at home + Borrowing from RBI + Borrowing from abroad.

Difference Between Fiscal Deficit and Revenue DeficitBasisFiscal DeficitRevenue Deficit

MeaningThe fiscal deficit is the excess of Budget Expenditure over Budget Receipt other than borrowings.Revenue deficit is the surplus of Revenue Expenditure over Revenue Receipts.

SignificanceIt reflects the total government borrowings during a fiscal year.It reflects the inefficiency of the government to reach its regular or recurring expenditure.

FormulaBudgetary Deficit – Borrowings

Or

BE – BR excluding Borrowings

(RE +CE)–(RR+CR excluding borrowings)

Revenue expenditure –Revenue receipts.

Or

RE – RR

Sources to Finance Fiscal Deficit

Following Are the Two Sources to Finance Fiscal Deficit:

(a) Borrowings

The fiscal deficit is accomplished by the borrowings from a commercial bank, internal sources like public, etc. or from the external sources like International Agencies like IMF, Foreign Governments, etc.

(b) Deficit Financing (I.e. Printing New Currency)

The government can also borrow funds from RBI against its securities to meet the fiscal deficit. Therefore, RBI issues new currency for this purpose.

This process is recognized as Deficit Financing.

What is the Finance Commission?

The Finance Commission was established by the President of India in 1951 under Article 280 of the Indian Constitution.

It was formed to define the financial relations between the central government of India and the individual state governments.

There have been fifteen commissions to date. The most recent was constituted in 2017 and is chaired by  K.Singh, a former member of the Planning Commission.

The recommendations made by the Finance Commission are only advisory in nature and hence, not binding on the government.

The 15th Finance commission makes recommendations for the period of 2020-2025 (5 years).

Importance of 15th Finance Commission:

The 15th FC has been set up in a time when huge reforms have been taken under the fiscal federalism:

Replacement of Planning Commission with NITI Aayog.

Implementation of GST reforms.

Abolition of the planned and non-planned expenditure.

Why in News?

Despite the strain on government finances due to the COVID-19 pandemic, there is no credible proposal to amend the legislation meant to control the fiscal deficit, Chairman of the 15th Finance Commission N.K. Singh said.

The government was currently looking to see how to ameliorate economic hardship while staying within the broad framework of the existing law.

While presenting the Union Budget in February, the Finance Minister had invoked the Fiscal Responsibility and Budget Management Act’s escape clause to relax the fiscal deficit target for 2020-21 by 0.5% percentage points to 3.5% of the GDP.

If the government wishes to increase spending further in light of the current crisis, as many economists have recommended, it may need to amend the Act.

The State governments have been demanding that their own 3% fiscal deficit targets be relaxed to 4% or even 5%, to give them elbow room in dealing with the impact of the lockdown.

Need for New Law:

Singh said that change would not be possible without fresh legislation being enacted by the States.

A more expeditious method would be for the States to first trigger their own escape clauses.

He also cautioned that the States need to weigh the cost of borrowing from the market, and whether there would be appetite for their bonds.

Economic Advisory Council members felt that options need to be considered for financing the additional deficit.

It is important to ensure that the State governments get access to adequate funds to undertake their fight against the pandemic, they said, adding that different States may come out of the pandemic’s impact in different stages.

A support mechanism for cash-starved small enterprises needs to be a top priority, along with partial loan guarantees and other measures to protect non-banking financial companies.

WILDLIFE BOARD NOD FOR MINING IN ASSAM ELEPHNAT RESERVEElephant Reserves of India:

The Government of India had launched the project Elephant in the year 1992 as a Centrally Sponsored Scheme with objectives to protect elephants, their habitat & corridors; to address issues of man-animal conflict; and welfare of captive elephants.

The project aims to ensure the long-term survival to the populations of elephants in their natural habitats by protecting the elephants, their habitats and migration corridors.

Other goals of Project Elephant are supporting the research of the ecology and management of elephants, creating awareness of conservation among local people, providing improved veterinary care for captive elephants.

Activities of the Project Elephant:

Ecological restoration of existing natural habitats and migratory routes of elephants;

Development of scientific and planned management for conservation of elephant habitats and viable population of Wild Asiatic elephants in India.

Promotion of measures for mitigation of man elephant conflict in crucial habitats and moderating pressures of human and domestic stock activities in crucial elephant habitats.

Strengthening of measures for protection of Wild elephant’s form poachers and unnatural causes of death.

Research on Elephant management related issues.

Public education and awareness programmes.

Eco-development.

Veterinary care.

List of Elephant Reserves of IndiaElephant RangeElephant ReserveLocation

East-Central landscape (South-West Bengal-Jharkhand-OrissaMayurjharna ERWest Bengal

Singhbhum ERJharkhand

Mahanadi ER

Sambalpur ER

Baitami ER

South Orissa ER

Orissa

Lemru ER

Badalkhol-Tamorpingla ER

Chhattisgarh

Kameng-Sonitpur Landscape (Arunachal- Assam) TotalKameng ERArunachal Pradesh

Sonitpur ERAssam

Eastern-South Bank Landscape (Assam- Arunachal Pradesh)Dihing-Patkai ERAssam

South Arunachal Pradesh ERArunachal Pradesh

Kaziranga-Karbi Anglong-Intanki Landscape (Assam- Nagaland)Kaziranga-Karbi Anglong ER

Dhansiri-Lungding ER

Assam

Intanki ERNagaland

North Bengal-Greater Manas Landscape  (Assam-West Bengal)Chirang-Ripu ERAssam

Eastern Doars ERWest Bengal

Meghalaya LandscapeGaro Hills ER

Khasi Hills ER

Meghalaya

Brahmagiri-Nilgiri-Eastern Ghat Landscape (Karnataka- Kerala-Tamilnadu-Andhra)Mysore ERKarnataka

Wayanad ERKerala

Nilgiri ERTamil Nadu

Rayala ERAndhra Pradesh

NilamburKerala

Coimbatore ERTamil Nadu

Anamalai-Nellianpathy-High Range Landscape (Tamil Nadu-Kerala)Anamalai ERTamil Nadu

Anamudi ERKerala

Periyar-Agasthymalai Landscape (Kerala-Tamilnadu)Periyar ERKerala

Srivilliputhur ERTamil Nadu

North-Western Landscape (Uttarakhand-Uttar Pradesh)Shivalik ERUttarakhand

Uttar Pradesh ERUttar Pradesh

National Board for Wildlife (NBWL):

The NBWL is constituted by the Central Government under Section 5 A of the Wildlife (Protection) Act, 1972 (WLPA).

It serves as an apex body to review all wildlife-related matters and approve projects in and around national parks and sanctuaries.

The board is advisory in nature and advises the Central Government on framing policies and measures for conservation of wildlife in the country.

It is chaired by India’s Prime Minister and its vice-chairman is Minister of Environment.

The NBWL has 47 members including the chairperson.

Among these, 19 members are ex-officio members.

Every new government constitutes a new board, based on the provisions of the WLPA, with the new PM as the chair.

Functions of NBWL:

The primary function of the NBWL is to promote the conservation and development of wildlife and forests.

It has the power to review all wildlife-related matters and approve projects in and around national parks and sanctuaries.

No alternation of boundaries in national parks and wildlife sanctuaries can be done without the approval of the NBWL.

North-Easter Coal Field (NECF):

North Eastern Coalfieldsis a unit of Coal India Limited, which has its headquarters in Margherita in Assam.

The unit came into existence in 1975 after nationalization of coal mines in India.

It took over the private mines operating in the Northeastern states of India and at present has mines operating in states of Assam, Meghalaya, Nagaland and Arunachal Pradesh.

At present there are five working mines – three underground and two opencast mines.

Why in News?

Amid the countrywide lockdown, the National Board for Wildlife (NBWL) has recommended coal mining in a part of an elephant reserve in Assam.

The NBWL’s Standing Committee had on April 7 discussed a proposal for use of 98.59 hectares of land from the Saleki proposed reserve forest land for a coal mining project by North-Easter Coal Field (NECF), a unit of Coal India Limited.

The NBWL is under the Ministry of Environment, Forest and Climate Change (MoEFCC).

Saleki is a part of the Dehing Patkai Elephant Reserve that includes the Dehing Patkai Wildlife Sanctuary covering 111.19 sq km of rainforest and several reserve forests in Sivasagar, Dibrugarh and Tinsukia districts.

Panel Set Up:

The NBWL had in July 2019 formed a committee comprising its member R. Sukumar, Assam’s Chief Wildlife Warden, and a representative of the local wildlife division for assessing the mining area.

In the April 7 meeting, Mr. Sukumar stated that 57.20 ha of hilly forestland had already been broken up by the user agency (NECF) and the remaining 41.39 ha was unbroken.

He recommended a “cautious approach” for preserving the “basic integrity of this forested hill slope” that is a part of the elephant reserve in Assam adjoining Arunachal Pradesh’s Deomali Elephant Reserve with “a sizeable population of elephants”.

After detailed discussions, the Standing Committee “recommended for approval” the proposal for mining in the broken-up area after the user agency submits a rectified site-specific mine reclamation plan in consultation with the Assam Forest Department.

IITD’S CORONAVIRUS DETECTION ASSAY GETS ICMR APPROVAL

IIT Delhi said it has got the approval from the Indian Council for Medical Research (ICMR) for a probe-free coronavirus detection assay developed by it.

The assay had been validated at ICMR with a sensitivity and specificity of 100%, making IIT-D the first academic institute to have obtained ICMR approval for a real-time polymerase chain reaction (PCR)-based diagnostic assay.

The assay was developed by researchers at IIT Delhi’s Kusuma School of Biological Sciences (KSBS).

Using comparative sequence analyses, the IIT Delhi team identified unique regions (short stretches of RNA sequences) in the COVID-19/SARS COV-2 genome.

These regions are not present in other human coronaviruses, providing an opportunity to specifically detect COVID-19.

It added that the method used primers targeting unique regions of COVID-19 that were designed and tested using real-time PCR.

These primers specifically bind to regions conserved in over 400 fully sequenced COVID-19 genomes.

This highly sensitive assay was developed by extensive optimisation using synthetic DNA constructs followed by in-vitro generated RNA fragments.

The research team said the assay would be useful for specific and affordable high throughput testing.

This assay can be easily scaled up as it does not require fluorescent probes. The team is targeting large-scale deployment of the kit at affordable prices with suitable industrial partners as soon as possible.

Clean code: The team has identified unique regions (stretches of RNA sequences) in the SARS COV-2 genome. IIT-DELHI

SERUM INSTITUTE EYES COVID-19 VACCINE BY OCT

The city-based Serum Institute of India has said that it expects the vaccine for COVID-19 developed by the University of Oxford in the market by October or November provided the safety and efficacy of the product is established during trials.

The institute has partnered with the Oxford vaccine project as one of the seven global institutions that will manufacture the vaccine.

In around two weeks, we can produce five million doses a month and scale that up to 10 million after six months while typically producing a vaccine takes a long time.

Observing that there were a lot of people who thought that they would have a vaccine in a few months, Mr. Poonawalla said there was, however, a strong caveat.

Trial Process:

If the vaccine works in the U.K. trial and we do another trial in India, which we are hoping to start shortly, in safety and efficacy, only then will it be available by October or November and that is only if we start producing at our personal cost in risk by the end of this month.

Further, he said the institute would be using one of the existing facilities for manufacturing the COVID-19 vaccine.

However, it will take over two years to set up new manufacturing facility for COVID-19 vaccine.

Typically vaccines take many years but with the regulatory approvals in India that have been very carefully changed for this product development, we are very pleased to announce that we will be able to do it by the end of this year.

SII is currently looking at 4-5 million doses monthly and would start manufacturing early to save time in the hope that the trial would be successful.

we hope to build up 20-40 million doses by September-October in the hope that if the trial works, then we will have this product.

SII would be partnering with ICMR for the clinical trials and that he was in touch with the Department of Biotechnology.

WORD OF THE DAYCaveat:

A warning or proviso of specific stipulations, conditions, or limitations.

[ezatluba]

Infectious Outbreaks Threaten the Last Asiatic Lions

Parasites and dog disease in India sweep through the cats’ only home, triggering fears for the species’ survival

Jaideep Hardikar on 

December 10, 2018

When two lion cubs were found dead one day this September in India’s Gir National Park, forest officials shrugged off their demise as “natural.” Three weeks later, however, 23 lions had perished—sparking fears an epidemic could very quickly devastate the last surviving population of the Asiatic lion.

Suspecting a viral outbreak, authorities captured the 19 remaining lions in the eastern edge of the sanctuary—the part where seven of the deaths had occurred—and isolated them individually at a care center. Only three survived.

The canine distemper virus (CVD) was initially blamed as the main cause of the deaths, but experts caution other factors were probably involved. “We need a serious multidisciplinary investigation of the outbreak,” says wildlife biologist Ravi Chellam. The deaths have sparked debate not only over their immediate cause but also about conservation strategies—and have reignited a decades-old call for some members of the endangered lion species to be transferred elsewhere as insurance against future calamities. Wildlife scientists say an alternative home is key to long-term conservation of the species.

As a further precaution after the recent deaths, 33 lions from an adjoining forest range in Gir were also captured and quarantined; when they will be released back into the wild remains uncertain. And although forest officials asserted the epidemic had been contained, at least eight more lion corpses turned up in different parts of Gir since October, raising the recent toll to 31. (No cause has yet been confirmed for the latest eight deaths.)

WHAT WE KNOW

All known remaining members of the species Panthera leo persica—the Asiatic lion—are confined to Gir’s 1,880 square kilometers and roughly 18,000 square kilometers of human-dominated landscapes surrounding the sanctuary in the Indian state of Gujarat. The population rebounded from a mere 20 in 1913 to an estimated 600 at present, a source of much pride to the Gujarat government. But the protected area itself can only support about 300, so many lions live precariously outside of it—in fields and orchards interspersed with villages and towns, and crisscrossed by highways and railway tracks.

With development hemming them in, Asiatic lions routinely die in accidents. Since 2015 six were hit by trains and two by trucks, 13 fell into village wells and several others died of electrocution, according to the state government. (Many farmers use electric fences to fend off crop-threating wild animals such as deer and boar; lions occasionally get trapped in them and die.) Overall 184 lions perished in 2016 and 2017 as opposed to 310 over the preceding five years—a worrying jump in the mortality rate, even before the latest spate of deaths.

In early October researchers at India’s National Institute of Virology (NIV) and, separately, the College of Veterinary Sciences and Animal Husbandry examined blood and other samples from the dead lions. Confirming officials’ suspicions, they found CDV—a highly contagious airborne pathogen that usually infects members of the dog family—and Babesia, a tick-borne protozoan. The NIV team also recovered a complete CDV genome; alarmingly it turned out to be related to strains found in east Africa, where canine distemper in 1994 wiped out roughly 1,000 African lions, amounting to 30 percent of their population in Tanzania’s Serengeti National Park.

In the villages around Gir canine distemper is endemic to domestic dogs—a major food source for lions living outside the protected areas. “Lions could either have caught CDV directly from them or from other carnivores—hyenas, jackals or leopards,” says Hari Shankar Singh, a member of India’s Wildlife Board and a former administrator in Gujarat’s Department of Forests. At the NIV’s recommendation, the government vaccinated all the Gir lions they had quarantined.

But it remains unknown exactly how CDV spread to the Gir lions. The virus can be present in an animal without causing sickness or death, notes Meena Venkataraman, a Mumbai-based wildlife biologist who runs a consultancy organization called Carnivore Conservation and Research. A detailed examination of clinical symptoms, along with postmortems and other detailed tests, are necessary to establish the extent to which CDV is responsible—and also to answer multiple other questions such as the prevalence of the disease in both lions and domestic dogs, she says.

On October 31 a dead lion cub turned up on a farm near Gir. According to Dushyant Vasavada, chief conservator of forests (Junagadh Wildlife Circle), it died of respiratory and cardiac failure caused by severe anemia and dehydration. These are symptoms of heavy tick infestation, indicating the possibility of Babesia infection. “The outbreak of CDV and Babesia protozoa may not kill a majority of Gir’s lions, but their threat looms large,” Singh says. He believes the underlying problem is not so much the presence of microbes and parasites (which is only to be expected) but rather compromised immune systems. “When immunity is lowered against the attack of any virus, the attack of CDV and Babesiaturns fatal to the animal,” he says.

Whether or not immunity is in fact impaired—and if so, why—also remain open questions. In principle, inbreeding could lower immunity by highlighting any deleterious genes present in the existing population.

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Venkataraman doubts this is the case, however. Inbreeding can result in reduced survival rates for cubs; but she notes cub survival rates in Gir are comparable with or better than in similar habitats in Africa. Also, climatic factors such as drought can dry up water sources and make food hard to find, lowering immunity and aggravating infections.

THE WAY FORWARD

Once the latest outbreak is dealt with, India needs to institutionalize a response via disease management protocols, Venkataraman says. “We must have contingency planning; disease can occur,” she adds. “It’s our preparedness and honest evaluations of such situations that is critical.” She claims the Gujarat authorities currently have no action plan for preventing infections, screening for pathogens or dealing with disease outbreaks. Decisions such as vaccinating wild animals “should not be made at the 11th hour when animals are dying,” she says.

Ensuring the long-term survival of Asiatic lions would require further measures, Singh notes. These would include the intensive use of genetics, forensics and virology to swiftly detect and respond to disease outbreaks; restoring habitats in the areas around Gir; closely managing the lions to reduce interactions with domestic animals; and moving a few prides to alternative sites.

But Gujarat has habitually balked at any move to relocate any of the lions. Regarding the animals as part of the state’s exclusive heritage, it insists they are safe in Gir. In 2013 the Supreme Court of India directed the immediate transfer of a few lions to another wildlife sanctuary that had been readied to receive them. The Court stated that preserving an endangered species was of paramount importance, overriding matters of regional prestige—but Gujarat did not comply with the court order.

G. K. Sinha, the principal chief conservator of forest and head of Gujarat’s Forest Force, did not immediately respond to e-mailed questions about the state’s noncompliance and findings about the recent deaths.

Relocating some of the lions would maintain an ecological and biological distance between two populations—thus helping to avoid possible inbreeding and to contain the spread of epidemics, says Chellam—who in the 1990s led a committee of experts mandated by the Court to study moving Asiatic lions to a new sanctuary. The committee had suggested three alternative sites. Of them, the Kuno Wildlife Sanctuary in Madhya Pradesh State—which lies 300 miles east of Gir and has historically been part of the range of Asiatic lions—was found to be best suited for their re-introduction.

With Gujarat showing no sign of relenting, however, the threat that the Asiatic lion could be extinguished by the latest crisis or by future ones remains a possibility. It is risky to “keep all eggs in one basket” irrespective of their numbers, Chellam says: “You’ll lose all the eggs if you drop the basket.”

[precisemarketreportsandinsights]

Dermatology Medication Market Size And Growth Report 2017 By Radiant Insights,Inc

This report mainly introduces volume and value market share by players, by regions, by product type, by consumers and also their price change details. As a Detailed Analysis report, it covers all details inside analysis and opinion in Dermatology Medication industry.

This report splits Dermatology Medication market by Dermatology Medication, which covers the history data information from 2012 to 2016 and forecast from 2017 to 2022.

Browse Full Research Report with TOC on https://www.radiantinsights.com/research/global-dermatology-medication-detailed-analysis-report-2017-2022

This report focuses Global market, it covers details as following:

Major Companies

•               ACTAVIS MID ATLANTIC

•               ALLERGAN

•               AQUA PHARMS LLC

•               B BRAUN

•               BARR LABS INC

•               BRACCO

•               CALL INC

•               DOUGLAS

•               DOW PHARM

•               DR REDDYS LABS LTD

•               EISAI INC

•               FOUGERA PHARMS

•               GALDERMA LABS LP

•               GLENMARK GENERICS

•               IMPAX LABS INC

•               JACOBUS

•               MARNEL PHARMS

•               MAYNE PHARMA

•               MEDICIS

•               MYLAN PHARMS INC

•               PERRIGO PHARMA INTL

•               PHARMALUCENCE

•               PLIVA HRVATSKA DOO

•               RANBAXY

•               SIGMAPHARM LABS LLC

•               STIEFEL LABS INC

•               TARO

•               TEVA PHARMS

•               TOLMAR

•               VALEANT PHARMS NORTH

Request A Sample Copy of This Report at: https://www.radiantinsights.com/research/global-dermatology-medication-detailed-analysis-report-2017-2022/request-sample

Main Regions

•               North America

•               United States

•               Canada

•               Latin America

•               Mexico

•               Brazil

•               Argentina

•               Others

•               Europe

•               Germany

•               United Kingdom

•               France

•               Italy

•               Spain

•               Russia

•               Netherland

•               Others

•               Asia & Pacific

•               China

•               Japan

•               India

•               Korea

•               Australia

•               Southeast Asia

•               Indonesia

•               Thailand

•               Philippines

•               Vietnam

•               Singapore

•               Malaysia

•               Others

•               Africa & Middle East

•               South Africa

•               Egypt

•               Turkey

•               Saudi Arabia

•               Iran

•               Others

Main Product Type

Dermatology Medication Market, by Dermatology Medication

•               Tretinoin

•               Isotretinoin

•               Xanthotoxin

•               Cesium Chloride

•               Trichloroacetic Acid

•               Adapalene

•               Zinc Oxide

•               Asiatic Acid

•               Calcipotriol

•               Anthralin

•               Sulfur

•               Psoralen

•               Crotamiton

•               Acitretin

•               Tazarotene

•               Calamine

•               Carbamide

•               Ichthammol

•               Salicylic acid

Main Applications

•               Department of Dermatology

•               Pharmacy

•               Hospital

•               Clinic

About Radiant Insights

Radiant Insights is a platform for companies looking to meet their market research and business intelligence requirements. We assist and facilitate organizations and individuals procure market research reports, helping them in the decision making process. We have a comprehensive collection of reports, covering over 40 key industries and a host of micro markets. In addition to over extensive database of reports, our experienced research coordinators also offer a host of ancillary services such as, research partnerships/ tie-ups and customized research solutions.

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[easyweight101]

Femi Yin Review (UPDATED 2017): Don’t Buy Before You Read This!

What is it?

Femi Yin is a supplement that claims to reduce the symptoms that emerge before, during, and after menopause. Femi Yin is designed to treat hot flashes, fatigue, night sweats, low libido, irritability and more.

Femi Yin contains a blend of Chinese medicinal herbs, a combination of detoxifying ingredients and cooling botanicals. This product is meant to be taken twice daily, and women should expect to see results within a week.

Our experts review countless hormone supportive ingredients and products and have learned that Femmetrinol is the best for helping women overcome symptoms like low libido, fatigue, hot flashes, insomnia and more. Click the link for an up close look at Femmetrinol.

Top Rated Menopause Supplements of 2017

Do you know the Best Menopause Supplements of 2017?

Femi Yin Ingredients and Side Effects

Femi Yin is made exclusively from herbs from traditional Chinese medicine. Here’s a quick look at what may be the the ingredients used to make Femi Yin:

Rehmannia Asiatic Dogwood Chinese Yam Tree Peony Bark Polyporus Alisma Anemarrhena Phellodendron Bark

Rehmannia: A staple in traditional Chinese medicine, rehmannia is used to make a number of health tonics and is thought to have a positive effect on the adrenal system and blood circulation.

Rehmannia is also used to cool down internal heat, which may explain its presence in this menopause supplement, as it may help reduce hot flashes.

Asiatic Dogwood: An herbal remedy for liver and kidney issues, dogwood may help improve spontaneous sweating, night sweats, dizziness and more.

Chinese Yam: A Chinese varietal of wild yam, this ingredient is used to treat various symptoms of menopause associated with hormonal imbalance like hot flashes, night sweats, vaginal dryness and mood swings.

Tree Peony Bark: The bark of the peony tree, this ingredient is used to promote blood flow throughout the entire body, lower blood pressure and enhance the immune system. It may help reduce joint pain, menstrual cramps, nerve pain, fatigue, PMS, colds and coughs.

Polyporus: A large, brown mushroom with diuretic properties, polyporus is used to support the lymphatic system and help with medical conditions like kidney stones, as well as any infections that might pass through the urinary tract.

Polyporus mushrooms also contain a number of minerals and micronutrients including retinol, thiamine, calcium and iron.

Alisma: Another Chines herbal remedy, alisma is used as a cooling herb which may help to reduce night sweats and hot flashes, as well as fight inflammation inside the body.

Phellodendron Bark: This ingredient is used for a wide variety of ailments such as diarrhea, obesity, weight loss, ulcers, tuberculosis, cirrhosis and diabetes.

Anemarrhena: An herb that “fights fire” according to traditional Chinese medicine, this ingredient is used to combat night sweats and hot flashes.

Click this link to learn more about the powerful herbs that can help fight hot flashes.

EDITOR’S TIP: Combine this supplement with a proven menopause pill such as Femmetrinol for better results.

Femi Yin Quality of Ingredients

Femi Yin is made entirely from herbs normally used in traditional Chinese medicine. Many of these herbs are thought to have a cooling effect, meaning they help prevent sweating and hot flashes, as well as reduce inflammation inside the body.

While there is some information about many of these ingredients, it’s hard to find much about whether or not these ingredients have any side effects or drug interactions consumers should be aware of before buying.

Femi Yin sounds like it may have some solid health benefits, and it’s easy to see why potential buyer may be attracted to something that boasts “cooling herbs.”

Regardless of how good this formulation might sounds, it’s definitely worth mentioning that there are no documented clinical tests on the Femi Yin website, meaning, we don’t know if it actually is all that effective or where the makers of this product are getting their information from.

Short of researching the basics of traditional Chinese medicine, we’re not sure consumers have much to base their opinion on aside from the reviews people left on various web platforms, most of which were not all that great.

A list of products designed to get that body back on track—click here to find the menopause support you need.

The Price and Quality of Femi Yin

Femi Yin may be purchased directly from the manufacturer’s e-commerce platform for $29.99 for a 60-count bottle. While the bottle says the serving size per dse is 1 pill, the website states that users can take up to four pills a day. So, the value really depends on how much of this product you’ll need to take each day.

You can also buy this product from various online platforms like iHerb, Amazon, Walmart, CVS and more. Femi Yin typically sells for $20-30, depending on who you buy from.

Click here to read our review archive and find the best menopause supplements of the year so far.

Business of Femi Yin

Femi Yin is made by a company known as BioMed Health, and they can be reached by using the contact information listed below:

Phone: 860-657-2258

Email: info@biomed-health.com

Address: PO Box 911

Glastonbury, CT 06033

BioMed Health is a natural supplements and beauty company focused on helping people both look and feel younger through a variety of herbal remedies.

This company only makes a few different products, including Femi Yen and a hair restorative supplement.

In looking at the Femi Yen page, the website provides some details about the herbs used to make this product and what customers can expect when they buy.

BioMed Health does give users a brief FAQ section, but they don’t dive deeper than answering a few questions about dosing and who Femi Yen is targeting.

Customer Opinions of Femi Yin

Femi Yin is not a widely reviewed supplement, but we were able to dig up some comments here and there regarding past users’ experiences. Here is some of the feedback we found for Femi Yin:

“I was hoping to find something to deal with the hot flashes and the general rockiness of menopause, but this only worked for a few months. I thought I was in the clear, but my symptoms came back strong.”

“After going through breast cancer treatment I was dealing with hot flashes all the time from the medication, then started going through menopause. A total nightmare, this hasn’t worked for me at all.”

“I do like the price, but that’s about all I can say. This product has done very little to help me deal with my menopause symptoms. I took the whole bottle and still, nothing has happened. Save your money.”

“I like Femi Yin—it helps balance out my hormone levels, making me feel calmer and less irritable. Plus, my hot flashes have been greatly reduced. I’d recommend this to a friend for sure.”

Many of the Femi Yin reviews mentioned this product did not work for them at all, even after taking the whole bottle. While some users might feel as though this helped them, it may not fully relieve severe hot flashes with some users.

Our overall impression of this supplement is that this may not be entirely effective for every user out there. Yes, some people received benefits, and few reported any negative effects, but this clearly is geared more toward those with milder symptoms.

It does seem to have a calming effect on many of the commenters we found, so this may be best for people more concerned with mood swings or anxiety than severe night sweats or hot flashes.

Looking for a better menopause solution? Experts share secrets to finding the most effective products for your changing hormones.

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Conclusion – Does Femi Yin Work?

Femi Yin doesn’t have great reviews, and is missing some of the key estrogenic ingredients that make other menopause supplements so effective. Many users claimed they used this product for several months and had yet to experience any major changes.

Femi Yin is made with a blend of ingredients we honestly don’t know all that much about, especially as a whole formula. It doesn’t contain the full range of hormone supporting ingredients you’ll see with a lot of products that have a similar use.

And while this product focuses on some more interesting herbs, they don’t go into detail about any of the science behind making this product. It seems like this formula, if proven effective in various case studies or clinical trials could offer a unique selling point for users who have tried more traditional menopause products without success.

Overall, between the reviews and the fact that we still don’t really have a great sense as to how well Femi Yin even works, we’d recommend that potential users look toward something else to address the symptoms of menopause.

After closely reviewing the formulas of just about every menopause product on the market, we’ve learned that, we now know Femmetrinol brings together the right combination of herbs to treat hot flashes, night sweats and other common symptoms without any negative effects.

Femmetrinol is scientifically formulated to bring users the key benefits they are looking for. Quality control methods from production to shipping are strictly regulated to maintain a certain standard. Get the facts on Femmetrinol, Click here for more.

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Heat claims a life in Gujarat

People complain of dehydration, nosebleed as mercury hovers above 43 tiers

With mercury soaring above 43 degrees C in the maximum of Gujarat, the State is witnessing severe warmness wave situations which have claimed one existence and affected masses in Ahmedabad and different cities.

One man or woman died of heatstroke in Ahmedabad city on Monday even as 518 instances of heatstroke, dehydration, fluctuations in blood pressure, anxiety were suggested in hospitals throughout the State.

Multiple proceedings According to the State emergency offerings, 2,368 persons had been suffering from the excessive warmth conditions when you consider that the start of May in Ahmedabad by myself. “People are coming in to whinge of dehydration, stroke, vomiting, chest and belly pain and nostril and ear bleeding,” a senior personnel member for the emergency clinical center advised The Hindu.

“We are witnessing intense warmness wave situations with dry weather across the State, except for some places in south Gujarat. Hundreds of patients are pouring in with heat-associated illnesses,” a senior medical doctor of Ahmedabad civil medical institution said.

Another senior physician from the metropolis said the majority of the sufferers were senior residents, youngsters and daily wage earners who were exposed to solar because of their work necessities.

Orange alert

The Ahmedabad Municipal Corporation has issued an orange alert as part of its warmth motion plan that has been organized and applied with the assist of specialists from the U.S.-based totally Natural Resources Defense Council (NRDC) and Indian Institute of Public Health (IIPH), Gandhinagar.

“We have alerted the residents to take precautions, minimize publicity to solar among eleven a.M. To 5 p.M. And remain hydrated throughout the day,” a senior respectable of the civic body said. “As in step with the met department’s prediction, warmth wave situations will keep for every other week within the State,” he said.

Meanwhile, a sudden change in the wind sample on Tuesday introduced in humidity.

“Owing to exchange in wind route, the relative humidity has become pretty excessive inside the State. In coastal areas, it is round 70-eighty% whilst in inland elements, it became 70%,” stated Jayanta Sarkar, senior meteorologist of Met office in Ahmedabad.

Heat Press Machine – Back to Basics

Heat press machines are a perfect choice for folks who perform a gift printing business. If you also want to start this commercial enterprise, professionals recommend that you provide a visit heat press machines. Choosing one is a chunk of cake if you recall your commercial enterprise desires first. Given under is an outline of different types of those machines that can help you choose one without any hassle.

Heat Press Machines

Primarily, heat press machines are available in simple kinds. They are called swing-away machines and clam machines. Let’s realize a piece about each the sorts and their distinguished functions. Afterward, you’ll read about different features that you must look for while shopping for one.Miami heat latest rumors.

Clam Heat Press:

A claim warmth press comes with a plate on its pinnacle that can be extended. When the device is in operational mode, this platen is going up. On the alternative hand, the lower platen tends to slide in the direction of the operator of the system. What makes this device first-rate is that it won’t take lots of room. So, you may deploy it even in a small room. For a small place of job, this device is an amazing preference.

Swing-away Heat Press:

This press works in an exclusive manner. Unlike the claim type, the higher platen of this device moves up and side-to-facet as nicely. The fact of the problem is that maximum of those press machines come with plates that may be moved around one hundred levels. So, you’ve got a lot of flexibility whilst using this press.

  Friction in Everyday Life

Are you privy to what friction is? How or what’s it utilized in regular lifestyles? Well in keeping with a Friction for youngsters, they say that you may discover friction anywhere of an item that comes into touch with each different, for instance, if a vehicle desires to stop at a forestall sign, it slows down so as for the friction among of the brake and wheels to stop. So to talk the forces that act in opposite course from the manner an item need to slide. Moral of all, fiction are forces that make a contribution to the sector each day.

For example, the time period fictions outline its self because the resistance forming by using items sliding towards every other. Let me provide you with examples of the know-how of sliding friction, the floor deformation of items, the roughness/smoothness of the floor of the gadgets, the unique speed of either object, the dimensions of the object, the quantity of pressure on both item or the adhesion of the surface, someone sliding down a slide is an example of sliding friction as well. Having those attentions frictions has many situations wherein they exist and wherein the sliding friction creates residences.

Now that you have an expertise of the Sliding Friction let me explain another regular sliding friction

Knowing that we are in bloodless wintry weather some of those you may relate to you and I bet you had no idea that fiction became worried within those movements. Rubbing both your fingers collectively to create the heat, a sled sliding across the snow or ice, Skis sliding in opposition to snow, a coaster sliding in opposition to a table, a washing machine system pushing alongside a ground, an iron being pushed throughout the material. Now that you have a better expertise of what sliding Friction is so when you come around them reflect consideration on how things absolutely work and not simply appear due to the fact you think it happens.

In conclusion, now knowing what friction is you might just stumble in this type of examples or similar examples within the destiny and you’ll be capable of researching them efficiently, what’s up! You may even percentage this with a person else and little do they know they’ll suppose you’re a genius. However, the coined time period friction helps us make the sector a more secure region to stay and definitely boom our productivity at the side of having an amusing environment in our residing conditions.

Gujarat Tour – Visit the Jewel of West

If you’re searching out an option to get enchanted with the cultural, nonsecular as well as historic panorama of India, ago to Gujarat can be the best alternative for you. This terrific piece of land is considered as the Jewel of West. The cultural and ancient traditions of Gujarat are originated because of the time of Indus valley civilization.

Gujarat is exactly located inside the sub-continent of India

The land of Gujarat is also listed below some of the top visitor locations of India. Therefore, it draws a huge variety of site visitors each 12 months. The country is also well-known for its seashores and longest sea shoreline. You may be capable of discovering many famous beaches in Gujarat that include Beyt Dwarka Beach, Ahmedpur Mandvi, Gopnath Beach, Chorwad Beach as well as Veraval Beach.

Apart from the lovely seashores and landscapes, Gujarat is also blessed with many holy temples and locations, architectural property, flora and fauna sanctuary, hill accommodations as well as many other interesting locations. The visitors of Gujarat can also revel in a wide range of elegant and stylish handicrafts, yummy foodstuffs, and huge-ranging destinations. The colorful lifestyle of the Gujarati human beings can even make your journey as an unforgettable one. The attraction of Gujarat never fails to draw the attention of travelers.

The fascinating wildlife of Gujarat is one of the foremost motives for the increasing variety of travelers to this region. Each has its specific environment and associated with each other in one or the opposite manner. The Gujarat natural world is likewise the habitat of different styles of animals. You also can discover some of the extraordinarily rare animals within the natural world location of Gujarat. The Gir wooded area of Gujarat is world famous. Asiatic lion is only visible inside the Gir forest.Gujarat tourism packages fixed departure.

When you are touring the wild lifestyles of Gujarat, you may additionally stumble upon many national parks as well as flora and fauna sanctuary. Some of the widely recognized natural world of Gujarat includes Wild Ass Wildlife Sanctuary, Sasangir National Park, Marine National Park, Nalsarovar Bird Sanctuary as well as Velavadar Blackbuck Sanctuary. It does no longer rely upon whether or not you are a journey traveler or an amusing lover, Gujarat can offer you the nice.

You will definitely have a colorful and top notch time in Gujarat

The warm-hearted Gujarati human beings will paint the colorful and colorful subculture of the kingdom. The Kutch embroidery clothes of Gujarat are widely recognized everywhere in the united states. This kind of clothing is laced with small mirrors which might be laid in shiny colorations. They are made by way of the tribal people of Gujarat. This is a tremendous art created with mirrors, beads, textiles as well as shades.If you’re planning to journey to Gujarat along with your family, taking the assistance of a travel company will assist you. This will assist you to save numerous cash.

[vigrxwarning]

vitamin d premature ejaculation

Contents

Nerves transmit signals

Healthy controls. healthy married

Symptoms. simply put

Acquired premature ejaculation (pe). materials

treatment 4 premature ejaculation BJU Int. 103, 940-949 (2009). A new topical spray-PSD502-for the treatment of premature ejaculation has shown promising results. “Our study shows that when the PSD502 spray was applied to.should i masturbate more premature ejaculation premature ejaculation and stds If you look at this picture you can probably understand why premature ejaculation can be caused by physical conditions like yeast infection. In fact, this picture shows a yeast infection of the penis, the condition is sometimes known as balanitis, although in this case yeast infection is affecting the whole of the foreskin and the shaft as well as the glans penis.Premature ejaculation is a very common – and treatable – condition. Being ready to talk about premature ejaculation will help you get the treatment you need to put your sex life back on track. The information below should help you prepare to make the most of your appointment.

and kidney beans are high in B vitamins that can balance hormone levels and help nerves transmit signals from the brain to the penis faster. If you’re dealing with premature ejaculation (PE.

Low serum vitamin D is associated with an increased likelihood of acquired premature ejaculation – May 2019. Int Braz J Urol. 2019 May-Jun;45(3):.

premature ejaculation hypnosis mp3 premature ejaculation treatment ring directions 3.1.4.1.3 Causes of ED that can be potentially treated with a. supplemented by the term “premature ejaculation” in all search fields, for the. The application of a constriction ring at the root of the penis (ACTIS) may improve efficacy [166, 167 ].. Penile implants are an attractive solution for patients who do not respond to.Whatever you need help with, it's odds on that you will find a CD or MP3 download file here that exactly fits the bill!

Sweet potatoes are very rich in beta-carotene, a plant compound that is converted into vitamin A in your body. Vegetables like broccoli and dark, green vegetables, such as spinach, contain many of the.

"Most men with premature ejaculation respond to daily treatment with SSRIs, and some respond really well," says Ira Sharlip, M.D., a clinical professor of urology at the University of California.

Purpose To compare serum level of vitamin D [25(OH)D] in patients with life-long premature ejaculation (LPE) versus healthy controls. Methods Healthy married.

To compare serum level of vitamin D [25(OH)D] in patients with life-long premature ejaculation (LPE) versus healthy controls. healthy married.

premature ejaculation etiology  · Premature Ejaculation and its symptoms. simply put, ejaculation is a male orgasm. It is described as the release of semen from the penis after an act of penetration or even masturbation. Premature ejaculation, as the name indicates, is a sexual dysfunction when the man has no or less control of when to ejaculate.

Low levels of vitamin D have been linked to poor male sexual function (especially erectile dysfunction) in previous studies. In this paper, a team.

Considering taking a vitamin or supplement to treat Premature+Ejaculation.Aspx? Below is a list of common natural remedies used to treat or reduce the symptoms of Premature+Ejaculation.Aspx.

Purpose: To investigate the relationship between 25-hydroxyvitamin D (25 (OH) D) levels and acquired premature ejaculation (pe). materials and Methods: A.

"A satisfying sex life can foster good emotional health, which in turn can promote good physical health," says Julia Heiman, Ph.D., director. in women and premature ejaculation in men.

Asian Ginseng, Asiatic Ginseng, Chinese Ginseng, Chinese Red Ginseng, Ginseng, Ginseng Asiatique, Ginseng Blanc, Ginseng Blanc de Corée, Ginseng Chinois, Ginseng Coréen, Ginseng Coréen Rouge.

10 rows  · Considering taking a vitamin or supplement to treat Premature+Ejaculation.Aspx? Below is.

To investigate the relationship between 25-hydroxyvitamin D (25 (OH) D) levels and acquired premature ejaculation (PE). Materials and Methods:.

Past research has found that vitamin D deficiency can affect the health of endothelial cells, too. These cells line the insides of blood vessels. For.

9 results. Vitamin B12. Are you getting enough? Take your medication. Vitamin D. Wonder pill or overkill?

source https://www.vigrxwarning.com/vitamin-d-premature-ejaculation/