#active pk side effects

[azuredeltaconsulting]

The Impact Of Modeling & Simulation M&S On Pharmacometrics In North Carolina

Modeling and simulation M&S in North Carolina- Durham to Raleigh, Research Triangle Park! Pharmacometrics plays a key role in drug development. And the involvement of Modeling and simulation methods has taken this field to a whole new level. It helps to design drugs, improve dosing regimens and deliver safer treatments to patients.

Drug development is a time-consuming job and expensive. Traditional methods come with limitations. It makes trials inflexible and offers limited space for adjustments based on emerging data. This is where Modeling and simulation come in.

Modeling and simulation allow you to create virtual representations of the human body and drug behavior. You can make mathematical models by using biological data, drug properties and physiological processes that show how a medicine cooperates within the body.

The Impact Of Modeling And Simulation On Pharmacometrics-

Optimized Clinical Trial Design-

Modeling and simulation allow you to design a clinical trial with better accuracy. You can know the suitable dosage range, the required number of participants and potential roadblocks. You can easily identify the most efficient approach to get the best results. it ensures smaller and faster trials as well as lessens costs.

Personalized Medicine-

Modeling and simulation enable you to know the variability of patients. It helps to make personalized models to know the action of the drug according to the patient’s age, weight, and medical history. It improves efficiency while reducing side effects.

De-risking Drug Development-

Modeling and simulation can remove the red flags. It meets the standard of safety concerns and improves efficiency. It encourages potential drug interactions and shows adverse effects virtually.

Accelerating Drug Discovery-

Developing new drugs is time-consuming for any risky illnesses. This is where Modeling and simulation accelerate the drug development process. By virtually testing different drug properties, you can ensure the faster delivery of life-saving treatments for patients.

Service offered at AzureDelta Consulting Inc.-

Modeling & Simulation and Pharmacometrics

Population PK, statistics, kinetics and pharmacokinetics data analysis and non-linear mixed effects modeling with Phoenix WinNonLin/NLME, conversion of published NONMEM models and coding, Quantitative Structure-Activity Relationship

Pharmacokinetic/pharmacodynamic and exposure-response correlation analysis; developing modeling and simulation strategy for clinical programs; use of simulation methods to support dose and dosing regimen selection, trial design and Go/No-Go decisions, dosing in pediatric studies; simulation of multiple options for the selection of best approach in drug development.

We add value to Modeling and simulation M&S in North Carolina- Durham to Raleigh, Research Triangle Park. Visit https://azuredeltaconsulting.com/ for more information.

Resource: https://azuredeltaconsulting.wordpress.com/2024/04/09/the-impact-of-modeling-simulation-ms-on-pharmacometrics-in-north-carolina/

[rafi420]

Points system and levels

Points systems are a way to motivate employees to perform specific behaviors. These behaviors may include completing HE Tuber tasks, achieving goals, learning new skills, helping colleagues, etc. In this gamification design for sales team effectiveness, points are obtained through the achievement of sales goals, sales process data, completion of daily sales tasks, and the development of sales capabilities.

Levels reflect employee progress within an enterprise's gamified environment. As points accumulate, the employee's level increases. High rank usually means higher status, greater responsibility and more rewards. Levels should be designed to be challenging yet achievable to keep employees engaged and motivated. In our racing game we have set up the following levels: Kart Racer, Sports Car Racer, China Championship Driver, World Rally Driver and F1 Racer.

Challenge tasks

In addition to daily game tasks, in order to increase the fun of the game, we have also designed a series of challenge tasks. Including individual challenge, individual PK competition, inter-team challenge, and challenge cup. The annual winner will also have the opportunity to have a private dinner with the sales president and a series of online and offline activities.

Medal system

Part of the charm of games is their uncertainty and surprise. A medal is a symbolic award given to employees for achieving a certain goal or completing a specific task. These tasks may include completing a difficult project, learning a new skill, or making a significant contribution to a team. Medals can give employees a sense of accomplishment, increase their job satisfaction, and encourage them to continue working hard.

In the early stage, we set about 30 medals from 5 dimensions, and this medal system will be constantly updated and improved. These 5 dimensions cover several important areas that we focus on for sales effectiveness, including sales performance, sales behavior, game participation, fun, and challenges, etc.

A day in the life of a typical user

Naturally, games should have strategies. We not only create game strategies for users, but also improve the user experience so that they can feel the fun of the game on a deep level, not just boring work and life.

Internal application scenarios of enterprise gamification

In addition to improving the experience of user training and sales incentives through gamification, it can also be applied in many other scenarios, such as:

Recruiting and employee onboarding: Through gamification, businesses can make the hiring process more fun and attract more talent. Product Development: During the product development process, gamification can inspire innovation and collaboration among teams. Health and Wellbeing: Gamification can also be used to encourage employees to focus on their health and well-being. Corporate Social Responsibility: Companies can use gamification to motivate employees to participate in social responsibility projects. Project management: Gamification can improve the efficiency of project management and improve the efficiency and productivity of the team.

In addition, like Pinxixi, users can obtain gold coins by watching videos, and these gold coins can eventually be exchanged for cash. You can't help but give it a try, right? This is a great experience!

Finally

We all hope that work can become more colorful and interesting, making your every day full of joy. As a B-side product manager, you may have found some inspiration in this article and start thinking about how to improve your user experience.

[fti-incorporation]

Permitted Daily Exposure (PDE) Certification

Quality is crucial: our quality promise

The Acceptable Daily Exposure (PDE) is derived based on the full available clinical and non-clinical data and is a dose at which side effects are unlikely to occur if a person is exposed daily for life. by any means at that dose or less. When different medicines are manufactured in shared facilities, the possibility of cross-contamination is an issue. Therefore, the presence of such contaminants must be managed according to risk, which in turn relates to levels that can be considered safe for all population groups.

FTI Incorporation is a Permitted Daily Exposure (PDE) Certification Company.

The PDE value represents a dose that would be expected to have no adverse effects on a person even with lifetime exposure. This is synonymous with the term ‘Acceptable Daily Exposure (ADE)’. The derived PDE values must be justified with a technical justification so that non-toxicologists (e.g. GMP inspectors) can also interpret and evaluate their content.

The general process for performing these calculations is as follows:

Calculation of Permitted Daily Exposure (PDE)

Develop and document a literature search strategy.

Execute the strategy by searching public and private scientific databases, scientific and medical journals, and internal preclinical and clinical registries.

Select and review key studies that provide relevant data.

Determine baseline (PoD) and any dosing or pharmacokinetic (PK) factors.

Perform the calculations using the equation shown in Fig. 1 and apply the appropriate uncertainty factors.

Prepare documentation.

Calculation of Acceptable Daily Exposure (ADE) (mg/day) = (NOAEL x BW) / (UFc x MF x PK)

Permitted Daily Exposure Values

Acceptable Daily Exposure (PDE) values are used by some toxicologists to aid in the safety classification of different types of impurities found in a drug substance (DS) or pharmaceutical product (DP). Acceptable daily exposure levels are important tools for the toxicologist, but one must be aware of their limitations to ensure they are used appropriately and effectively in the risk assessment process.

First, a toxicologist should always conduct a thorough analysis of all available data on the safety of a pollutant for humans and animals, including identifying any data gaps that may exist.

Second, if sufficient data are available and there are no genotoxicity concerns, an appropriate and well-designed repeat-dose animal toxicity study should be selected to calculate the PDE.

It is important to note that PDE values assess overall systemic toxicity and not necessarily local tolerance endpoints such as irritation and sensitization, which are concentration rather than dose dependent. In addition, a PDE value calculated from a general animal toxicity study is not necessarily suitable for reproductive toxicological endpoints.

Finally, PDE values should never be considered as analytical limits or acceptable levels of an impurity in a DS or DP as this fails to address quality considerations. Using safety information for various chemicals as indirect contaminants, this article serves as an educational introduction to facilitate a better understanding of the development and use of PDE values in the risk assessment process.

We provide PDE reports for all active pharmaceutical ingredients (APIs). There are already a large number of existing reports to choose from, but we're happy to create a new one to add to the list of additional APIs if needed.

Our focus is on the quality of each individual report. While not all reports may be available for instant download, we can ensure you get exactly what you need for the current situation and in the best possible quality.

To ensure this, our quality promise includes:active membership of FTI Incorporation in the EUROTOX Corporate Program

an experienced and multidisciplinary team of EUROTOX-certified toxicologists

Compliance with the official EMA guideline

PDE reports with a comprehensive structure so that all information is easily accessible

PDE reports are based on the toxicological properties and pharmacology of the specific active ingredient

[chartlomo]

Play dying light 2 early

Play dying light 2 early install#

Play dying light 2 early upgrade#

But eventually, you realize there’s just too much fun to be had taking out huge swathes of zombies in one go. Environmental tools abound, too, like gas canisters you can pick up, light, then throw with satisfying accuracy.Īt first, you’re told to only enter zombie hives at night when many of them are out roaming the streets. The best weapons can be upgraded with fire, explosive, electricity or poison effects. Guns are, mercifully, completely absent, and the weapons are cobbled together from rusty machetes, street signs, cricket bats and the like, although you do also find bows. If you time your block perfectly, you can vault over the nearest zombie and launch a vicious flying kick at any other zombie in the vicinity. There are some great combat moves, such as one in which Aiden simply whirls around in a circle, damaging anything within range of his blade. Cute touches abound – for example, to craft health packs, you need to scavenge honey, chamomile, lavender, and resin.Īs Aiden levels up, better weapons and armor become available, and he soon becomes a satisfying zombie-dispatcher.

Play dying light 2 early upgrade#

Killing vast numbers of different types of zombies yields Infected trophies, which you can cash in at a Craftmaster to upgrade those blueprints. Craftmasters will sell you blueprints for useful offensive and defensive objects such as mines, Molotovs, health packs, and immunity boosters that stop you from turning into a zombie when you’re away from UV light (which basically fries the Infected). Then there’s a vast amount of loot to collect, including crafting materials, weapons, armor, and valuables that can be sold to merchants. This changing city is one of the big new features added to Dying Light 2, but it isn’t enormously successful, amounting to more of a curiosity than anything that significantly changes the gameplay.

Play dying light 2 early install#

Plus there are crucial infrastructure buildings, including water towers, windmills, electrical sub-stations and Metro stations, that Aiden can power up or unlock, and then assign to specific factions, which will physically alter the surrounding area – Survivors will install ground-level crash-mats allowing you to fall from heights without damage, while PKs will set up zombie traps. The story also branches, forcing you to make decisions at certain points, thereby earning favor or scorn with particular characters or individual factions – although you can often afford to be a bit cavalier, since pretty much everyone you meet will betray you at some point. Completing the story missions, side missions, and the many random activities dotted around the city reward XP to spend on new parkour and combat abilities.ĭying Light 2: Stay Human is a complex, full-blown RPG masquerading as a mere zombie game. For example, Aiden can collect Inhibitors, which allow him to improve his base stats for health and stamina (the latter crucial for both combat and parkour). It boasts a dizzying number of systems that feed into each other, yet cohere in near-miraculous fashion. It swiftly becomes apparent that, to an even greater extent than the first game, Dying Light 2: Stay Human is a complex, full-blown RPG masquerading as a mere zombie game. That GRE key – the only means of unlocking anything GRE-related, of which there is plenty in Villedor – eventually becomes the game’s prime plot MacGuffin. On the way to Villedor, Aiden acquires a GRE access key – the GRE being the medical, quasi-paramilitary organization that sprung into action to find a cure for the first game’s viral outbreak in Harran, but was blamed for further outbreaks and hounded into oblivion. Haunted by memories of childhood experimentation, he is on a quest to find his sister Mia, and his investigations lead him to the city of Villedor. Dying Light 2’s protagonist, Aiden, is a so-called Pilgrim, one of the few intrepid humans willing to venture outside the walled cities that remain. Its events take place 15 years after the original viral outbreak depicted in the first game, and show a world in a dire state (in a way that strikes plenty of chords after our own real-life pandemic experiences). It’s somewhat ironic that Dying Light 2 swiftly makes you feel at ease, since the environment it plunges you into is anything but comfortable.

[yolandawakers-blog]

[gentletwin]

Headcanon: Lucas, mind-reading, empathy, and how it affects his everyday life.

Lucas and Claus’s PSI abilities weren’t apparent from birth, the way they are in some of the other Mother party members. They definitely displayed some early signs of having some sort of special abilities, such as Lucas’s propensity for understanding animals even before he could literally understand them. But they weren’t, say, levitating objects straight out of the womb. Those overtly psychic abilities wouldn’t become apparent until after Ionia awoke it in both of them.

That being said, Lucas can read your mind...but unlike other, more experienced psionics, he has to actively do it. Rather than walking by and just hearing a conversation in passing, it’s more like having to open a door in order to hear what’s being said on the other side for him. Not exactly a huge amount of effort, but still a conscious activity. But generally, he doesn’t open that door unless a) he’s given permission, b) he opens a telepathic conversation first, or c) he reads the room and feels like it’s necessary.

What does come to Lucas fairly unconsciously, though, is the emotions of others. He was already very sensitive before having PSI; unlocking those abilities just made him more of an empath in a very literal sense. He’s adjusted to this sensation and can generally compartmentalize his feelings vs the feelings of others in very low-stakes situations. It’s when emotions run hot that this experience gets more intense for him.

Sticking with the door analogy, it’s as if he were to walk past a door and, while not being able to make out the exact words that are being said unless he actively tries, he can definitely pick up on the tone of what’s being said without much effort at all. Not a huge deal if it’s just mundane small talk happening on the other side of that door; he can just sort of acknowledge it and move along, or just let it slide through his subconscious mind. But if someone on the other side of the door was letting out giddy victory cries, or sobbing audibly, or having a heated argument with someone else — that’s when the emotions come to the forefront of his mind. It might be why he’s so good at being the shoulder to cry on, despite being so young.

The flip side is that, for such an emotional person, his PSI is especially susceptible to changes in his emotions. An especially potent PK Love fueled by a desperate desire to keep his friends safe; a PK Fire in a Smash match that burns especially hot with competitive spirit; an especially effective heal fueled by desperation not to lose anyone else; it’s all well within the realm of possibility for him.

All that said? You probably wouldn’t want to have seen what Lucas looked like when confronting Porky.

[project-rebirth]

Overview: Espers

An esper (能力者 Nōryokusha?, lit. "Ability User") is an individual who uses scientifically based supernatural powers and emits AIM. The term usually refers to those enrolled in the Academy City Power Curriculum Program, who gained their powers artificially, but can also refer to natural espers, also known as Gemstones. It is also used to refer to magicians by those unaware of the magical nature of their abilities, and therefore treat them as esper-related.

In-universe, espers have only existed for a few decades up until this point.

Terminology

The original Japanese light novels used the term "Ability User", but before the licensing of Toaru Kagaku no Railgun, the majority of the English-speaking fandom substituted it with "esper". Because its use has become widespread, this wiki uses the term "esper".

A queer event related to this is Seven Seas' English translation of the first volume of A Certain Scientific Railgun, which opted to use "psychic", a term that has been used before by the fandom until "esper" became the standard. Because of this, the English fans that were accustomed to the use of "esper" lobbied for "psychic" to be changed, and Seven Seas acquiesced, even referencing the incident later.

The term "esper" does not automatically imply ESP, one of the two classifications of powers in Academy City, as it could also refer to an ability user that does not have extrasensory perception but instead influences objects in their surroundings, referred to as Psychokinesis. Abilities such as Pyrokinesis are considered esper powers despite the user not having extrasensory perception.

Principles

Academy City's espers have existed for over half a century in the world of Toaru, with the first modern esper being a girl nicknamed "the Beginning Child", who was trained by Academy City based on Meiji-era psychic Mifune Chizuko's data. The system used for the Beginning Child would become the foundation for the Power Curriculum Program to create espers.

Espers are described by Index as individuals with "talent"; this likely refers to Gemstones and each cannot use magic without injuring themselves. An esper is created after passing through the Power Curriculum Program, thanks to which the esper now possesses a Personal Reality, their capacity to substitute reality with their own which is the basis of their abilities, with no two people have the exact same one. In contrast to Magic's Idol Theory, their interference with and subsequent distortion of reality to create effects is an isolated phenomenon based on quantum theory, their observations of the world based upon their Personal Reality affecting things on a micro quantum level to cause phenomena on a macro level. An opposite theory would be holism, where a large interference with the laws of the whole world is used to make effects on a smaller scale. Aside from the mental performance of calculations, no elaborative and preparatory rituals are required by an esper to produce effects related to their abilities, unlike in Magic.

Espers can only access one specific power; Misaka Mikoto, for example, can only control electromagnetic phenomena. Despite this, however, researchers have attempted to create espers with multiple powers, such as Dual-Skill and Multi-Skill espers. Moreover, esper abilities are compartmentalized into two categories: Active and Passive. Active abilities require conscious effort to use, while passive abilities require subconscious effort. Abilities can be classed as both active and passive, such as Accelerator's ability. Esper abilities are further grouped into two major categories, Psychokinesis (PK) and Extrasensory Perception (ESP), with PK having a higher precedence in the classification of esper powers than ESP, especially when an esper power sits on both sides of the boundary between ESP and PK.

Another aspect of espers is that every one of them, even Level 0s, subconsciously radiates an AIM Diffusion Field, minutes amount of their power in a way akin to body heat and weak enough that it can be felt by any of the human five senses and is only detectable through machines. Different powers means a different AIM Diffusion Field: a Pyrokinetic for example will emit AIM that will heat up their environment, a Telekinetic will emit pressure, and an Electromaster will emit a weak magnetic field. According to the Professor, AIM is not simply weak energy emanating from espers, but the unconscious interference against reality, and analyzing its composition and strength gives more insight into the Personal Reality of a given esper than a psychological profile. There does seem to be some direct connection between the AIM Diffusion Field and Personal Reality, if Takitsubo Rikou being able to affect the latter through the former is any indication.

Esper powers are controlled using complex calculations done mentally, so strongest espers are also Academy City's greatest honor students. Because esper abilities rely on mental calculations and concentration, if anything affects the esper mentally, be it pain, exhaustion, surprise, or confusion, they will not be able to perform the calculations needed and their powers won't work. The AIM Jammer takes advantage of this, essentially disturbing espers' concentration.

While the brain is an important component to esper power, it is not the only factor. The entire physical human body is also part of this system and controls the power, though the exact mechanism is not well understood. Produce tested and researched to find out where exactly in the body esper power resides, removing limbs, organs, and brain parts from subjects, but the power still remained, although its output decreased as the body grew smaller, leading the researchers to conclude esper power can only reside in a body containing something that could be called a soul. Likewise, it is shown that, as long as something is considered a part of the body by the esper, esper abilities can be used with it, no matter if that part is attached or detached, artificial or natural. Kuroyoru Umidori can use Bomber Lance through her detached cyborg arms, which she considers parts of her body; Kakine Teitoku can control his Dark Matter even if it's not directly touching his body by no longer distinguishing between his actual body and the parts fabricated from his power; and Rensa operates by changing her biological structure to that of other espers so she can use their abilities. Coffins also operate on this principle, tricking the brains of dead espers into thinking bigger mechanical bodies are their own, which in return make the power stronger.

Genetics also have some influence on esper powers, and DNA can be used to determine esper powers. The very existence of the Parameter List and its ability to predict the future development of an esper before even passing through the Power Curriculum Program might be due to this fact, especially as they used it to get the DNA map of a future Level 5 for cloning ahead of time. Another manifestation of this is how siblings tend to get the same or similar powers: the Tobio twins have the exact same power, the Yumiya sisters have the same power but at different Levels, and Acid and Counselor both have oxygen-related powers. And, while they are not true siblings, there are no clones, or Sisters, of Misaka Mikoto with non-electrical powers. This is not an absolute rule: for example, the Gokusai sisters, or at least Kaibi and Amazora, have completely different powers. The triplets Ichika, Futaba, and Mitsumi likewise each have a different power. It may be that the possibility of similar and identical powers is weaker for ordinary siblings and fraternal twins than it is for identical twins and clones, who share the exact same genetic makeup.

Academy City's curriculum begins at 5-years-old at the earliest, and hormones generated during puberty and adolescence are considered critical to esper development. This might explain the prevalence of espers of kid and teenage age. In fact, it seems that is impossible to become an esper if one is an adult, to the point that the existence of adult espers is seen as improbable. So far no adult esper have been shown to exist, aside from those who used various means to artificially get esper powers, like Kiyama Harumi with Level Upper, Kihara Gensei with Exterior, Houjou Seigo with Ideal, and Kihara Byouri with her Equ.DarkMatter implants.

Ultimately, espers are considered only a byproduct of the Power Curriculum Program on the way to reach SYSTEM, with the reasons and mechanisms behind their existence being the actual objective of the city's scientists. Aleister compares espers to litmus papers changing colors in solutions of different acidities: the interest is in why they changed colors and if it can be manipulated, not the colors themselves. Essentially, espers are a means to an end, not the end itself.

Power Curriculum Program

A person enrolled in this program is called an esper and, through a series of drugs usages and experiments, will be cut off from regular reality and enabled the capacity to substitute it with their own. Espers are ranked according to their System Scan results, which evaluates six attributes to determine the rank of an esper: Precognition, Clairvoyance, Psychometry, Telepathy, Psychokinesis, and an unknown sixth one. It is stated that Level 0 espers barely have enough influence to pass the curriculum's grading exams.

Any individual can use the curriculum to acquire powers, such as Misaka Mikoto, who started out as a Level 1 and worked hard during her training to become the 3rd ranked Level 5 esper in Academy City. There are exceptions of course, as with the case of Level 0s. Furthermore, with the Parameter List, it is apparent that esper potential is limited by various factors. This has resulted in researchers determining that it would be wise to focus on developing an esper whose ability is worth more to the city and whose training is predicted to be more resource efficient than that of another person's.

Information regarding the students enrolled in the curriculum, such as their abilities, their level and a brief description of them, is available in the Data Banks of Academy City. Furthermore, certain espers, such as Kamijou Touma, have security protocols in place to ensure that the truth of their abilities is classified.

According to Uiharu Kazari, the name of an esper ability, such as Electromaster or Telekinesis, is decided by the school that its owner is enrolled in. Only under specific conditions can the name of an esper ability be decided by its owner, such as the Railgun. Railgun's editor Ogino Kentarou further elaborated later that there are three types of names for abilities: public ones, the ones that the esper themself applied for and registered, and self-declared names. It is unknown, however, as to what exact conditions an esper must meet to officially name their own esper ability, though its uniqueness may be a factor.

Currently, only Academy City can create espers, although others have tried, such as during the Stargate Project.

Gemstones and speculation

A Gemstone esper is an individual who can emit AIM without requiring participation in any power development program. Gemstones are the beings that Index likely referred to as having "talent"; the envy of their abilities from their peers is what led to the creation of magic. There are currently 50 confirmed Gemstones in the world.

In extension to this, it has been speculated that there may be people who have not realized that they have powers, or that their certain propensities or idiosyncrasies, as subtle as good looks or good penmanship, may actually have this power.

Many Academy City students are aware of Gemstone rumors, but treat them as urban legends. This is due to many feeling that it is unfair for esper powers to be gained without having gone through the Power Curriculum Program to attain them. Currently, Sogiita Gunha, who is the strongest Gemstone, and Himegami Aisa are the only two known Gemstone's in Academy City. Kamijou Touma, as mentioned by Kumokawa Seria, does not classify as a Gemstone esper as due to his powers being unrelated to AIM; it is believed that Imagine Breaker is beyond the current understanding of Academy City researchers.

[thepowerofsecret]

Ceremonial Magic Some Secret Sources Of Energy

Many systems have been developed over the ages to help us control our thoughts. A great amount of dogma too has been kicked around in an attempt to make us into better people. Magick (the occult kind, spelled with a ‘k’) is one of the oldest and most general of these systems. Magick is the study and application of psychic forces. It uses mental training, concentration, and a system of symbols to program the mind. The purpose of magick is to alter the self and the environment according to the will.

Most of the magick we see today comes to us from ancient Egypt and Chaldea. The Chinese, Hindus, and Tibetans developed their own unique types of magick.

Western magick was locked up by the Egyptian priests for thousands of years and then suppressed by the rise of Christianity. It was not until medieval Europe that the alchemists and Cabalists rediscovered magical knowledge. Only during the past hundred years or so has western culture been open minded enough to permit widespread investigation of the subject. Only since the start of the twentieth century has science shown much interest in it al all.

Parapsychology and Psychic Phenomena

Through parapsychology, we are gaining insights into the hidden nature of man. Parapsychology is a branch of psychology, which studies psychic phenomena. It remains something of a frontier, even today. Perhaps one reason for this is that psychic phenomena are somewhat inconsistent. Nevertheless, there is strong evidence from numerous cases and experiments in support of psychic phenomena. Somehow, under the right conditions, the mind can directly affect the environment.

We may theorize that the human mind and body broadcasts a kind of psychic energy or force, much like a radio station. Kirlian photography, temperature effects, cloud chamber tests, and other experiments tend to support this theory. Although the exact nature of this psychic force is subtle and unknown, it is undoubtedly the energy behind all psychic phenomena and magick. However, it is not a radio wave, since it behaves somewhat differently. The psychic force is too weak to be measured directly (at least so far as we know). Everyone has some psychic ability. There are numerous types of psychic phenomena. Parapsychology separates them into two groups: ESP and PK.

What is ESP?

ESP, the abbreviation for extra sensory perception, means the reception of information through paranormal means (ie. not regular physical senses of sight, sound, touch, smell, or taste). In theory, this is accomplished by receiving psychic force from outside the body. Here are some examples of ESP:

Clairvoyance, or Remote Viewing — the ability to sense or ‘see’ (non-physically) distant objects, places, and people. Individuals who see ghosts and spirits are probably clairvoyant.

Clairaudience, or remote hearing — the ‘hearing’ of paranormal information.

Astral Projection (OOBE) or Travelling Clairvoyance — Full experience at a remote location while the physical body sleeps.

Psychometry — the reading of information by the touch of physical objects.

Telepathic receiver — the ability to directly receive thought (communication) at a distance, with no physical connection to the sender. There are many everyday examples of this, in which we think something just as another person is about to say it. This is an easy one to test for through experiment. Very dramatic cases of telepathy have been recorded; there is often an emotional element in such cases.

A ‘channel’ or medium, as in a science who is in direct communication with a ‘spirit’ or entity.

Experience with a Ouija board, pendulum, or automatic writing.

Precognition — to foresee the future. Again, highly emotional events are the ones most likely to be ‘tuned in’.

Retrocognition — knowledge of the past, by paranormal means.

What is PK?

PK, the abbreviation for psychokinesis, is the active or sending side of psychic phenomena. The theory here is that psychic force is sent out from the individual. Examples of PK include:

Telepathic sender — the transmitter in the telepathy just discussed.

Psychokinesis (or telekinesis) proper — the ability to move objects by means of psychic force.

Somewhat along the same lines are poltergeist (noisy ghost) phenomena in which objects move of their own accord or noises are heard. There is always a human agent involved — frequently a teenage girl — who appears to be the source of psychic energy.

Psychic healing — the ability to heal various illnesses and infirmities. There are many documented cases of this. Usually it involves a healer and a subject, although there are recent cases involving cancer patients learning to heal themselves.

Teleportation, asportation, and levitation.

Some occultists feel a magician producing PK effects is simply a channel for universal energy. Others think the force originates some way directly within the magician.

The Subconscious

Postulated by Freud and others, the concept of the subconscious mind is an important one. Basically, this is the idea that part of the mind normally operates below or outside of ordinary consciousness and awareness. Dreams and hypnosis are examples of this. Also subconscious are the many automatic functions of the physical body such as respiration and digestion

[born2battle]

Tenure in Peace Station @ Dhrangadhra

     The Regiment settled down in the new location at Dhrangadhra before the Republic Day 1983. Thereafter, our Recce group consisting of the CO, all Battery Commanders and selected JCOs/ NCOs proceeded for op area familiarisation in Munabao -- Gadra -- Barmer sector. It was a novel experience to visit the areas close to the International Border. Munabao is the last railway station on the Indian side while Khokhrapar is the last station on Pakistan side. The railway line connecting both these stations, which are 10 kms apart, was in a state of disuse.. We faced several challenges peculiar to desert terrain during our op recce. The biggest problem was vehicle & foot movement on desert tracks & across sand dunes, without any landmarks for navigation. Setting up of a Base camp for our Recce party was equally difficult due to shortage of potable water, frequent sandstorms and temperature variations during day & night. However, the optical illusion due to the mirage effect was a soothing experience. 

    We returned after the desert orientation of three weeks. Thereafter, our CO planned & conducted an intensive orientation training for the remaining personnel. It helped us in preparation for the Annual Practice Camp which was scheduled in May just before the onset of the monsoons. The Camp was scheduled in Tikkar Field Firing Ranges in the Little Rann of Kutch, in close proximity to Dhrangadhra. The Rann gets submerged in sea water during the monsoons. Hence, all firing practices had to be completed before the rainy season. These Ranges are famous for the Indian Wild Ass Sanctuary. 

      In Apr, the result of the Staff College Exam was declared which was a big disappointment for me. I felt so disheartened since I had not made it in the merit list although I had qualified in the exam. It took me lot of time to accept this reality because I could not reconcile with this failure. On introspection, I resolved to take a mental break and bounce back in my next attempt for this prestigious Course. Sanjivani as well as Team 98 proved to be my pillars of strength at this critical stage in my career. I assured myself with the adage -----” Never let success get to your Head, Never let failure get to your Heart.”

       We moved to Tikkar Ranges where we faced different challenges in the very first Practice Camp, in the Rann of Kutch, due to the peculiar nature of the soil. The deployment areas had to be selected on relatively firm ground. The gun pits could not be dug due to the sub- soil water level. There were additional problems during the firing because the spades of the gun got embedded due to the recoil force. Consequently, there were inaccuracies in engagement of targets which posed a safety hazard. All vehicle movement had to be done by the compass bearing method. Interestingly, on one occasion, we had to fire star shells continuously, to illuminate the route for guiding the movement of the COs Party over a distance of 10 kms, from the gun position to the observation post.

     We returned after the Camp and got busy with the preparations for the Raising Day celebrations. This year, these celebrations were on a grand scale because of completion of 20 glorious years since raising. Soon thereafter, Lt Col Jagir Singh who had received his posting order earlier, moved out after handing over the charge to Lt Col PK Lama in mid Aug 1983. I was detailed to accompany the new CO for briefing him in the op area at Munabao. 

    Meanwhile, we took over our  permanent  accommodation which was quickly converted by Sanjivani from a new ‘House’ into a new ‘Home’. Ultimately, we could open up all our bags and baggage, which had been packed  so meticulously, before moving out from NDA. Hence, we could organise  a Study Room for myself and an exclusive Play Room for Ashvini & Nandini, on priority. I commenced my preparations for the Staff College exam in right earnest, with a stronger resolve. 

     Life in a Peace Station, though peaceful was always active, due to a variety of competitions, not only for the officers & jawans but also for their families. Our “Chhore” excelled in all the sports competitions which enabled maintaining a high state of morale always. All the amenities in the Cantonment such as Shopping complex, Open air Cinema hall , Army School & the Military Hospital enhanced the quality of life. Celebration of  all the festivals by the Regiments, as per the class composition of the jawans was a major attraction. These activities organised centrally in the Cantonment, created  a vibrant celebratory mood throughout the year due to the festivals such as Kite festival, Pongal, Holi, Baisakhi, Onam, Navratri (the most popular festival in Gujarat) and ofcourse Diwali ---  which was celebrated with a fabulous illumination & fireworks display. 

            My First Impressions about the Balwan Family...

     I along with both my young daughters, Ashvini ( age 2.5 years ) & Nandini ( age 3 months ), reached Dhrangadhra in May 1983. We were allotted a temporary accommodation consisting of two rooms and an open balcony which was converted into a small kitchen, screened by a tarpaulin on the outer side. I had to immediately cope with this challenge of settling down in this restricted space, with only the essential items. I was helped by the support system of the Fauji family while adjusting with my new neighbours in the new environment. The Jat Balwan Family proved to be my extended family. The COs wife was considered as the mother in the Regiment. Under her guidance, we learnt to share the responsibilities of looking after all the families in the Regiment. 

     Family Welfare Centre established in the Unit was the hub of all activities. We held meetings with the families every month and heard about their problems/ difficulties so as to find quick solutions. We organised few competitions and cultural programs on the occasion of various festivals. We also carried out visits to their accommodations and advised them about improving hygiene and sanitation of their premises. Coaching classes were also conducted for the children whenever required. All these activities enabled establishing a bond of friendship and mutual trust.

     My husband was a Battery Commander and was responsible for about 150 Jawans of Papa Battery. I was responsible for looking after the welfare of  about 70 families. I learnt to interact with the families informally during the Barakhana, Fauji Mela and various festivals. It gave me a lot of satisfaction when the families and specially the children were happy and satisfied. It is true that the Jawans perform their duties efficiently only when the their families are being looked after adequately. The system of Family Welfare worked so smoothly at all levels in the Regiment since the wives of the officers performed their duties whole-heartedly with a smile.

     The winter season was the period of collective training in the deserts. We participated in exercises with the Infantry Battalions & refined our SOPs for operations in the desert terrain. Thus, we improved our technical proficiency gradually in each exercise. Our BC & OP parties practised their role while patrolling the sand dunes on camel back, which certainly was not an easy ride. Our Gunners also refined the movement and deployment drills for the Guns in the desert terrain.

     In Jan 1985, I received the much awaited and eagerly expected news about the result of Staff College exam. This time , my name was in the competitive merit list of Top 20 achievers, who had secured Distinction. I felt extremely delighted as it was yet another step on the ladder of success. I thanked the Almighty for his divine blessings & looked forward to moving to Wellington for the prestigious Staff College Course, by end of the year.

      It was time for Lt Col P K Lama to move out on completion of two years. He was given a memorable farewell  as he handed over the Flag to Col R S Gill in mid Sep 1985. I felt so lucky to have served under three COs, in three years in the same location. It was an invaluable experience to observe & learn the unique style of command of each Commanding Officer. I was really impressed with their different styles of leadership, different motivation techniques, different man management concepts while maintaining their focus towards Pursuit of Excellence, which inspired the Jat Balwans towards ---” Jazbaa Jeet Ka” !!

[touhou-gensoudairantou]

Terra Casts a Spell On You! (Magitek Elite Madame)

Overview: Beautiful, mysterious, kind… all great words to describe Terra Branford. A young half-Esper lady taken from her home by the Gestahlian Empire and raised as a living weapon before a mission in Narshe gone wrong has her wind up in the company of the Returners. Her magical capabilities are incredible, even without factoring in her power-doubling Trance, her incredible Apocalypse sword, and the abilities she gained from Magicite. But be warned, she lacks useful recovery a good amount of the time, and she can be quite frail.

Gimmick: Terra's Trance morphs her body into her Esper form upon maxing out her Gauge, which fills over time. In this state, she's all around much stronger. With doubled speed, power, and defense… that is, until she uses a Special Move, Bomb, or Final Smash… or y'know… gets launched off-screen or loses a her Stamina. Also, when at 100% damage or higher, all Smash attacks gain a 1/16 chance at becoming the powerful Desperation Attack Riot Blade, which has great range and four strikes. Riot Blade will also get rid of your Trance, so please keep that in mind.

Standard Attack: A slash, a stab, and a Fire spell. Quite basic really, but the stab has Terra advance forward.

Her tilts are various slashes.

Her Dash Attack is a jumping slash.

Smash Attacks: Do you know the name Cyan Garamonde? He’s a party member in Final Fantasy VI who is sadly quite outclassed. A real shame too, he has a great design, and his samurai motif is very appealing. Well Cyan, today is the day of your vindication! Terra, who spent quite a long time studying your Bushido skills, is ready to use them to great effect in Smash! They're way cooler than what I initially planned. Keep in mind, the names used here are combinations of their Japanese names and their original English localizations. (To put it better, JP first, Woolsey second!)

-Side Smash: Kiba Dispatch. A quick, ultra-strong stabbing lunge.

-Up Smash: Mai Quadra Slam. Four upward sword strikes that do good damage.

-Down Smash: Sora Retort/Tsuki Stunner. Essentially a counter attack that has a 3 second window of effect. If struck during this window, Terra will retaliate with a slash that has a decent range. If she's not struck, she will rain down blades made of ki, which are very prone to stunning enemies.

Neutral Air: Blizzard. A spin of ice that can freeze enemies.

Forward Air: Fira:

Up Air: Blizzara: An icy somersault that can freeze enemies. Deals much more damage than Blizzard.

Back Air: Thunder. Kicks back a bolt of lightning.

Down Air: Thundara. Does a lightning-charged stomp.

Neutral Special: Active Time Battle Menu. A variant on Hero's Command; this one has all options available at a times. Can move around a lot more, but you don't really have very few options for buffs and such. If you're having trouble with the movement while the menu is up, the Taunts have been disabled in this state so you can use the buttons to help make your selection. Better make it quick, this menu lasts only 2/3 of the time of Hero's!

-Bio: Sends forth a poisonous cloud a few feet in front of Terra. If it hits, it does about 9% and leaves the enemy with fast-acting poison for 5 seconds.

-Flare: Does damage in a very high column that can counter enemies.

-Protect: Halves all damage for 10 seconds.

-Thundaga: Fires off a massive beam of electricity that does great damage. It's very easy to jump over, however.

-Cura: Restores 30%. (50% in Trance)

-Graviga: Slams down every enemy within range of the platform Terra is on. Hurts an awful lot more if they were in the air.

-Quake: Trips and damages all opponents on the ground you're on. Deals 10% to you.

-Banish: A spell that can instantly defeat an opponent. Increases in effectiveness at higher percentages.

-Flood: Sends rushing water that can damage and carry away enemies.

-Meltdown: Deals the most initial damage out of ATB Menu's spells (at a whopping 50-80%) and has the longest burning effect, range, and spread, but at the cost of dealing a flat 30% to Terra herself, which triples in Trance.

-Tornado: Rips up everyone's percentages to 300%. And I do mean everyone. Only use if you're extremely desperate. Considering Terra's pretty light, you'd better be ungodly careful.

Side Special: Holy. Think Robin’s Arcfire, but with no burning damage. To compensate, it'd be a bit stronger.

Up Special: Firaga. Propels Terra upward with a concentrated burst of flame. Deals 20-28% on direct contact and leaves a burning effect.

Down Special: Summon. Using the power of your Magicite, you can summon an Esper's power to devastate opponents with powerful magical attacks! But beware, during this you stand completely still, and are unable to move until the Esper disappears. You're resistant to knockback and damage, but if your opponent can get in enough damage that can break your concentration/launch you, you're a sitting duck. In addition, the Esper Terra summons is entirely random, so you'd better make sure your teammates are covering you or pray for your own safety. And if you get it off, you can't activate this special again for 30 seconds. She has 4 potential summons.

-Maduin: Chaos Wave. Unleashes a tide of raw anger upon all opponents within Terra's range. Functions similarly to Mario Finale or Marisa's Master Spark.

-Valigarmanda: Tri-Disaster. Fires off a series of screen crossing beams with wide-ish range in many directions. Can burn or freeze opponents.

-Midgarsormr: Abyssal Maw. A far more powerful version of Quake that can even hit enemies in the air in a wide radius around Terra.

-Bismarck: Breach Blast. A far more powerful version of Flood that significantly increases spread and damage.

Bomb: Meteor. Summons down a series of meteors that strike enemies. It's basically a slightly less good PK Starstorm.

Final Smash: Trance Ultima. Terra goes into Trance and rushes across the stage. Like Joker, if she misses her target, she can turn the opposite direction and attempt to strike again. Once her targets have been struck, a cinematic plays where she charges up, then casts Ultima. Once it finishes, they are launched quite far.

And I know I don’t usually talk about Shields and such but eh… this time I'll make an exception.

Shield: There's a second long window where Terra will Reflect all projectiles. It’s quite easy to miss, but if you can hit you'll be rewarded.

Stage Entrance:

-Rides in on a Chocobo, and jumps off as it rides away.

Taunts:

-Imitates that piece of her Yoshitaka Amano artwork at the bottom.

-Turns to the screen and looks down.

-Briefly takes on an aura colored after her Esper form.

Victory Screen: Like Cloud, she uses the Victory Fanfare from her game.

-Celebrates in earnest with FF6's victory animation, often giggling.

-Hopes back onto the Chocobo, and rides toward the screen, saying “Apologies…” or “You won't be forgotten.”

-Downs an Elixir, and smiles at the camera.

Alts:

-She also has palettes based on her fellow Returners’ sprites from the same game. Specifically, Locke, Edgar, Shadow, Gau, and Strago. No Celes? How come? Well… that's currently a trade secret. It will be revealed in due time, dear readers.

-One of her alts is based on her sprites from Final Fantasy VI, as done by Kasuko Shibuya. Essentially, her Second Form from Dissidia.

-Her last palette is based on the battle sprite of one Kefka Palazzo. He's a very iconic villain among western fans, thanks to, in no small part, his dark but humor-filled dialogue and his Joker-like mannerisms. He just might be worthy of his own character slot.

Special thanks to @spooner-the-trinity for the suggestion. ...and apologies for taking so long oof.

[astrocenter]

Interpretations of moles on the Head and Forehead – What do they tell?

Moles are marks which can be found on different parts of the body. In Indian and Chinese Astrology, moles are interpreted as representing the destiny of the person. The influence of the planets on the person would start at the time of fetus formation in the mother’s womb. Some planets influence the fetus more and some less.

I will explain the moles and their relevance for women in the coming articles and blog posts. For now, let us discuss the effects of moles according to their placement on head and forehead, especially men:

                        Moles on the right side of head:

If a mole is found on the right side of the head, then it is very likely that the person will excel in politics. If the color of the mole is red or green then the native will either become a minister or a president of a local body or a community organization.

Moles on the left side of head:

If the mole is on the left side of the head, then the native will not have enough money. Mole on the left side also delays the marriage. The native may very likely not marry.

Moles on the back side of head:

A person having moles on the back side of the head earns a lot of money, but his money making activities also earn him a bad name in the society. The native here will also have weakness for women.  The person will also be very attached to his wife.

Moles on the right side of the Forehead

A mole on the right side of the forehead represents wealth. The person also earns fame and good name in the society. He is likely to be a devotee of God. He will have a very helpful nature.

Moles on the left side of the Forehead

If a native has a mole on the left side of the forehead then the native will be very selfish. He may not be very helpful to others. He may not command respect from his near and dear ones.

Mole on the Forehead in center

A native having a mole in the center of his forehead, is going to be lucky for his beloved.

Parmod Kumar-Ex AGM Punjab National Bank

PK Astrocenter-Rajpura

A Banker turned Astrologer. I research and practice Astrology, Numerology, Palmistry and face readings (Psychic)-Parmod Kumar Known as PK Astrocenter.

For astrological remedies please email at pkastrocenter@gmail.com or post your query at http://pkastrocenter.com/horoscopeanalysis.You may join with me face book parmod kumar, Group Pk Astrocenter.

This site is for premium customers and charges apply. For Astrological guidance and consultations you may reach on mobile numbers 8860017788 or 7009270427 on whatsapp

[sportsb3t-blog]

Clever Sport Betting Guide rapid Understanding the Basics

betting

Sports wagering has been around for centuries and has produced in popularity in the the past few decades due to technology. Now you can area a bet online using your favourite sports book, or maybe make a selection on your cellphone - all these at the ease and comfort of your own home. Sports gambling has never been easier in the record of mankind to think on sports.

betting

Sports gaming can definitely provide extreme fascinating excitement to those passionate about sports activities as well as the serious bettors obtaining a way to make smart money. Ahead of one embarks on athletics betting, it would be wise to be familiar with basic of sports betting.

On this page you will learn the 8 standard terms and definitions common in betting on sporting activities.

1 . Straight Bets

An aligned bet is the most common side bet. This is where you wager about the same side to win. Direct bets can be made applying either the point spread or perhaps the money line or the sport total to go over or below. The format of collection will vary depending on the sport that you're betting on.

2 . Parlays

A parlay is a wager with two or more teams (events) in which all teams should win. Since it is more challenging to predict multiple situations than it is for a one event, the payout chances increases as the number of bundled events increases.

3. Teasers

A teaser is a special type of appliance of parlay in activities betting in which you adjust the actual spread or total of each one individual play. Additional details are either either included with the underdog or deducted from the favorite. The price of transferring the point spread (teasing) is leaner payout odds for earning the teaser wagers.

some. Props

In sports bets, a prop is a particular wager offered by the sports activities book on unique along with various topics. These gamble can be on sporting events, state policies, and even trial outcomes. Typically the wagers use the money series format of pay off probabilities and might included for example who have scores the first touchdown within the super bowl, or who'll win the next presidential will, or whether or not O. T. will be found guilty.

your five. Futures

In sports bet, futures odds are posted before hand on the winners (a group or a player) of various key events or tournaments at the beginning of a season. The odds can change as the season or contest progresses and it will change as outlined by each team's performance inside the series. However the odds in the course of your wager will remain in place.

6. Total (over/under)

Within sports betting, a total gamble is to bet on the merged number of runs, points as well as goals scored by both equally teams during the game, such as overtime. You can bet Around - In sports wagering the over is a athletics bet in which the bettor guesses that the combined point entire of two teams are going to be above a specified total. You might as well bet Under - In relation to sports betting a beneath is a wager in which the player guesses that the total things scored by two squads will be under a certain range.

7. Point Spread

Inside sports betting this is the believed scoring differential between a pair of teams as quoted by way of a sports book. A "line" is set for each game with the odds makers. Favorites should have a - (minus) indicator followed by a number, while the underdogs will have a + (plus), followed by a number. Here's an illustration NFL line:

Chicago and 7

Baltimore -7

Baltimore is the favorite and need to win by 8 factors or more to win. Whenever they win by exactly 8 points, the game is a "push" or tie, and you receive the amount of your bet again. If Baltimore wins by simply 6 points or a lesser amount of, or loses the game, subsequently those that bet on Which you could will win the money.

In most situations you'll see a 1/2 place, for example Baltimore is -7 1/2 points. This reduces "pushes" since a crew can't score 1/2 a degree.

Sometimes you'll see games where spread is "Pick" or even "PK". That means the line is usually 0 and no points come in effect... just pick the victorious one. Point spread bets might be either "straight" or "parlay" bets.

8. Money Traces

In sports betting, they can be odds expressed in terms of dollars. With money odds, every time there is a minus (-) anyone lay that amount to gain a hundred dollars, where there is a plus (+) you get that amount for every number of dollars wagered. The subtract sign is for the most favorite while the plus sign is designed for the underdog.

Well, Hopefully this article will offer some basic information and understanding and may probably provide some help to your own personal sports betting.

Towards your regular winning on sports gambling!

[winterpower98]

PKNE Droids

Part 1

Part 2

Part 3

[I am Paperinik and I’m a hero!]

[I live in the 21° century, but I happen to travel to the future!]

[Sme time ago, someone tried to stop me...]

PK: ... and maybe today you're trying to make me waste time!

PK: Hey, where...

???: PK?

PK: Tyrrel Duckard?

PK: I’m ok, thank you for asking! And you?

Robot Agent: Do not move, this is a police check!

Robot Agent: You are violating the law on public order!

Tyrrel: Everything in order, agent!

Tyrrel: We were chasing the wanted man who knocked out my partner!

Tyrrel: Excuse him, he woke up a little confused!

Robot Agent: Explanation recorder, you can go!

PK: Let me understand too ... especially why you’re calling me partner!

Tyrrel: Because we work together!

PK: You and I?! But you were the one who wanted to erase my reality!

Tyrrel: UHM ... You got hit pretty bad!

PK: You mean you weren't the one ...

Tyrrel: Who knock you out? If so, why would I have taken you to 2179!

PK: Who am I suppose to thanks then?

Tyrrel: I’ll explain everything with a warm drink!

Bartender: Nice cape, friend!

PK: Thank you, I’m happy it’s still an ongoing trend!

PK: Well then? Talk!

Tyrrel: I’m in this century because of an ongoing investigation!

Tyrrel: Since the timepolice has reinstated me ...

PK: O-oh! You’ve become a good droid!

Tyrrel: You can bet!

PK: Keep going then, I’m listening!

Tyrrel: Even if you can’t remember it, we are on the same team!

Tyrrel: You understood that when I came and asked for your help!

Tyrrel: The situation is delicate, a group of droids escaped from the 23° century!

PK: This should be an everyday job for you?

Tyrrel: Not this time! The timepolice discovered where they went ...

[ ... And when! A decisive year for their evolution!]

Tyrrel: We were about to capture them, but something went wrong!

PK: GULP!

PK: Let me guess! They put me k.o.!

Tyrrel: Yup! We located their hideout!

[ While I was inspecting it, you stayed outside on lookout ...]

[ And one of them caught you off guard!]

[ LuckllyI had all the necessary to neutralize their weapon effects!]

Tyrrel: And when you woke up, you hit me!

PK: I suppose I own you an apology then!

Tyrrel: Nevermind, partner! Let’s get back to the hunt instead!

Robot agent: Bartender!

Robot Agent: Those two are regular customers?

Bartender: UMPF! Luckily they’re not!

Bartender: That guy with the ask ruined my menù in 20° century style!

Bartender: It was printed on authentic vintage replypaper!

Tyrrel: This is my office!

PK: So, you’re here in official capacity!

PK: I thought you timepoliceman acted in disguise!

Tyrrel: And it is! This is only a cover!

Tyrrel: I came from the 23° century and in 2179 time travel was already invented, but it’s secret! I can’t attract attention!

PK: Don’t worry, the furniture isn’t too flashy!

PK: But I did expect a device to track down the fugitives’ signals!

Tyrrel: They don’t have any signals, they are standard models!

Tyrrel: Only us timepolice droids have locators and cronoengine!

PK: The how did they escape!

Tyrrel: From a normal public cronostation! Those droids are property of Ruvo Chandra, a big guy in 2298!

Tyrrel: The temporal travel permit was in his name!

PK: Great! Now tell me you don’t even know what they look like!

Tyrrel: Don’t exaggerate, I have their record card! She is Zyba, personal secretary of Chandra!

PK: An updated model of miss Quackfaster! EH EH!

Tyrrel: Miss who?

PK: Nevermind, keep going!

Tyrrel: Soren was his bodyguard ...

Tyrrel: And Moris his attending replica!

PK: Attending what?

PK: Use my words, I can’t understand yours!

Tyrrel: “Attending replica” means he is Chandra lookalike!

Tyrrel: Every celebrity has one for dangerous or ... annoying situations!

PK: It’s not much to track them down!

Tyrrel: We have another clue! I found it in the timepolice archives!

Tyrrel: Recognise someone?

PK: Impossible! I have never been to this future before!

Tyrrel: Well, this proves the opposite!

PK: I ... don’t understand!

PK: Actually yes! You used me!

Tyrrel: Nothing personal, everyone knows your the droids friend!

Tyrrel: You could have been in league with them!

PK: And if this is another me?

PK: One that came from who knows which century, for example!

Tyrrel: plausible hypothesis! Meanwhile, take a look at the view!

Tyrrel: If you didn’t notice, there is the headquarters of Robolab!

PK: The name is not new ...

Tyrrel: I believe it!

Tyrrel: It’s the society that has been studying droids since the 21°t century!

PK: I don’t think I saw any of them around!

Tyrrel: At the moment there are only robots, but in a few years droids will be everywhere!

PK: EH EH! They will fall in price?

Tyrrel: They ever told you you’re funny? They lied!

Tyrrel: The Robolab was bought by a young genius who will revolutionize the research!

Tyrrel: You should know him, his name is Odin Eidolon!

PK: Maybe he is the goal of the fugitives!

PK: What could they want from Odin?

Tyrrel: For example, grant droids more freedom rights from the beginning!

Tyrrel: Or take his place!

PK: You’re raving! They don’t look like him!

[ But this gives them an advantage because Eidolon never appeared in public!]

Odin: Good day, gentlemen!

Tyrrel: Once in command of his industries, the droids could rewrite history!

PK: ULP! No trace of the other me ...

PK: ... But that is Soren!

Tyrrel: Stop! If we follow him he will bring us to his ...

???: Detective Duckard?

Inspector Wuff: I am Inspector Wuff! I would like to talk to you!

Tyrrel: Hard to say no with those assault Robotagents that are with you!

PK: Don’t try to escape, big guy!

Soren: OOOH! PK!

Soren: What are you doing in the 22° century? I would never have hoped to meet you here!

PK: Eh?! Did you hear him ...

PK: ... Duckard?!

PK: This was not planned!

PK: Now you tell e why did you hit e and what are you and your partners planning!

Soren: I ... what?! And What partners?

Soren: We left the future to save us!

Soren: Let me explain!

PK: Alright, but be convincing!

Soren: Good, but let’s go away from here ...            ... There are too many curious persons!

[Here is a completely different thing, eh?]

PK: There are at least one billion people!

Soren: Exactly! In this crowd, who would think of us?

Soren: Zybra and Moris will be here in a bit!

PK: I wonder why did I let you call them!

PK: If you’re thinking of pulling a trick, you didn’t understand anything!

Soren: I just want to tell you everything with them!

Soren: I’m not good with words, I’m programmed as and action droid!

PK: I know! After all, you’re the one who sent me sleeping before!

Soren: GASP! D-do you often do that?

PK: Actually, I didn’t remember being able to! Maybe it’s the amnesia!

Soren: It looks like a verification protocol of the mnemonic transfer!

PK: Protowhat? What are you talking about?

Soren: During the memory upload, fragments of elementary contents are distributed!

[The droid activates only when ...]

[ ... manages to reassemble them!]

Soren: Are you sure no one manipulated your memory?

PK: What have I got to do with it? I’m not a droid!

PK: But she is!

PK: She didn’t see us, let’s go to her!

Tyrrel: PK!

Soren: ARGH!

Tyrrel: Don’t lose time! Neutralize him!

Soren: I thought you were on our side!

PK OOF!

Tyrrel: Move! We’ll lose him!

PK: I can’t use the shield with all these people!

Tyrrel: old-fashioned scruples?

Tyrrel: At least moved from the shooting line!

Men: YAGH!

Soren: You won’t take me back!

Men: UH?

Soren: I didn’t do anything bad!

PK: Are you alright?

Tyrrel: Yes! Nice catch, partner!

Tyrrel: Now let’s finish the job!

PK: But .. he’s not stopping!

PK: Is that gadget useful for something or is it only ornamental?

Tyrrel: Don’t be in a rush!

Tyrrel: He’s slowing down, see?

Tyrrel: The inhibitor disables any droid without risk to living beings!

PK: The effect is not really instantaneous, eh?

Tyrrel: No, but it works! Why didn’t you use it?

PK: Maybe because we don’t have that in the 21° century!

Tyrrel: That’s why I gave you one, forgetful!

PK: GULP!

Tyrrel: Look here! How much interesting material!

Tyrrel: There is nothing else, we can deliver him!

Tyrrel: The Chrono - translational will bring it back to the 23rd century!

[ An unwanted journey in the future would confuse anyone, but not PK! Well, more or less .. by the way: better to travel in time at a standard speed and in a week you will know how the mission is going! ]

Tag list

@adamarinayu​

@bamboozledeagle​

@zanarnaryon​

@glowing-gravity​

@keriwi1

@pinkpearlapple

@aj-the-bluejay

@emilieschwarz9887

[adamarinayu]

From the Shadows

Notes: Shadow!Della AU, in which Scrooge faced off with Magica after Della laid her eggs, and Della stepped between Scrooge and the curse rather than Scrooge deflecting it. Also includes teen!PK (AKA Donald was PK in his teen years), former secret agent (DoubleDuck) Donald, MAGIC!Donald, and all sorts of secrets for our best daduncle. Also includes past Donald/Various but basically no pairings. 

Also Della knows basically none of this, sans the magic.

It wasn’t quite a question of how it happened, or even why. Donald knew the answers to that.

An adventure gone wrong. Magica’s spell- Della jumping between them, the ancient artifact the magician seeked in hand- he didn’t remember much after the blinding light and the burning rage. After Magica was defeated and run off- after he and Scrooge had that screaming match- after his uncle left with the artifact and Donald left with the only four things of his sister she left behind.

Her three eggs and her scarf.

No, it wasn’t a question of how, or why.

It was when.

“Donald.”

He didn’t want to wake up, clutching her scarf close to his chest as he desperately clung to the dream that she was still there- still by his side- still within his reach.

“Donald.”

He could almost swear he still heard her voice. She-

“Donald, wake your tailfeathers up and look at me!”

Donald jerked up and looked around wildly, eyes wide. His grip on her scarf tightened, and after several seconds sitting there in bed, the moonlight gently spilling inside his window of his grandmother’s house, he spotted it.

He spotted her.

Against the wall, a shadow so much darker than the ones around. Her shape was recognizable- her goggles, her hair, the way she held her arms at her side- the way she waved-

Her eyes, or what should have been her eyes, glowed an almost gentle blue as she gazed from the wall to him.

Tears stung his eyes. “Della...”

“Hi, Donald!” She laughed, a sound Donald was sure he’d never hear outside his dreams again-

Wait. Was he dreaming?

“I don’t- what- I don’t understand what’s going on,” Donald stuttered, eyes never leaving his sister.

“I don’t know, either,” Della admitted, her shadow shifting closer to Donald- sweeping over the headboard where the light shouldn’t have allowed any shadow to be. She almost seemed to be sitting on his bed next to him. “I think I’m trapped somewhere? I don’t know. Everything was purple for a while, and then suddenly I was here!”

How? Donald wanted to beg her to answer him, but he knew she couldn’t.

He was imagining, right?

“I think it has to do with that,” Della added, reaching her hand over to the scarf- as if pointing at it. “One moment I was trapped and then... I felt an opening. I slipped out and I was here! And the scarf was glowing. Did you do something again, Donnie?”

Again? Maybe. It had been years since Donald used magic- for all he knew he could have. Could he have unintentionally drawn his sister’s... Spirit... being back to the real world, creating a link through her scarf?

Could he?

Or was it a side effect of Magica’s spell?

Regardless, Donald felt a sudden certainty that he could never let that scarf go again. He’d need to relearn magic- learn everything over again, if only so he could maybe bring her back completely.

If it was possible.

If he wasn’t dreaming.

Was he dreaming?

“Oh, Donnie, please don’t cry... I didn’t mean anything by it, I promise.”

He was crying? Yes, he was crying. Della’s shadow tried to reach out, but her hands couldn’t touch him.

Tears burned tracks down his cheeks as he choked in a breath.

“Please be real,” he begged, voice breaking as he stared at her. “Please be real.”

“I’m real,” she promised quietly, a strange sadness falling over the two of them. No. Not strange. His sister was gone.

If she was real- if she was trapped somewhere, and he had given her access to the real world- maybe he could free her. She wouldn’t miss her children’s lives.

“They’re- they’re about to hatch,” he told her, wiping his eyes. “Grandma says... says it’ll be just- just a day or two now. Gods, I hope you’re really here- please don’t miss them. They- they deserve a mom, Della...”

“I’m here,” Della assured him, her shadow looking across Donald and Gladstone’s childhood bedroom to the nest set up in the corner, where three eggs were swaddled up ready to hatch, three ducklings ready to enter the world. “I wouldn’t miss this, Donald- this is our greatest adventure, yeah?”

Hearing his own words repeated, his own words from that argument they’d had hours before she took the hit for Uncle Scrooge- when she was wanting more, more, more, to go to space and adventure and give her children the stars-

“We’re enough! This is our greatest adventure yet, can’t you see that?!”

He let out a sob and buried his head in his arms, realizing belatedly that he still clutched Della’s scarf.

He almost would have rather she took on the stars.

Magic was Donald’s thing. Not Della’s.

He should have taken the hit.

If he had kept up with his magic like his mentor had told him to- if he had just... done what he should have... Maybe he could have deflected it.

Maybe his sister would have been there. Maybe Magica would have been the one damned to a world of shadows.

“Look on the bright side, Donnie,” Della started, and he could almost feel a phantom hand on his shoulder. “I get to see my boys grow up.”

And it just wasn’t bright to Donald, because she should have been the one raising them.

She should have been the one to sign the hatch certificates.

She should have been the one to sign field trips slips.

She should have been the one attending PTA meetings.

She should have been the one driving them to school and activities. The one to teach them the meaning of promises. The one to teach them that family helps family.

Instead, she could only help him be everything she should have been, all from the shadows.

[emk-irl]

Evolving War of PDE5 Inhibitors

Since 비아그라 정품 was released in Korea in 1999, the development process of domestic oral erectile dysfunction drugs has been a field of competition for oral erectile dysfunction drugs around the world. It has continued to evolve and develop through the fierce competition for survival in the pharmaceutical industry, which is reminiscent of war.

The start of this competitive evolution began in 2003 when Tadalafil (Cialis) of Lilly and Vardenafil (Levitra) of Bayer started domestic sales, and 비아그라 정품 met the first round of the battle for oral erectile dysfunction drugs. An ideal oral erection stimulant should be able to be used in combination with other drugs because of its rapid action, excellent erectile effect and longevity of erection, reproducibility of a certain effect, low side effects, and low drug interaction. It should have various characteristics, such as being able to receive and having a low price. In this period, the efficacy and safety of the three oral erection stimulants of the single dose method were mainly emphasized, and the pharmacokinetic superiority of each drug was emphasized.

Therefore, regarding the efficacy and reproducibility of drugs, the characteristics of each drug were emphasized, such as fast-acting using Tmax and T1/2, duration of action using T1/2, and AUC (area under the curve) on the PK curve, and enzyme selectivity using IC50. As for safety, data on enzyme selectivity, drug metabolism, and drug interaction were presented.

In particular, he emphasized that Cialis is a long-acting agent with a longer duration of action compared to two drugs, and not only can maintain an erection for a long time but also does not require daily consumption. It emphasized the rapid onset of effects as an advantage and set it up as a sales strategy.

On the other hand, 비아그라 정품, as an aid, had demonstrated efficacy and patient satisfaction in terms of efficacy and safety accumulated from sales use for about 5 years at the time. In fact, Viagra was released in 25, 50, 100mg, Cialis 5-10-20mg, and Levitra 10mg and 20mg. was recommended to be reduced.

In addition, if there is a burden on the price or if the degree of erectile dysfunction is not severe, the tablet may be divided arbitrarily.

Meanwhile, in Korea, in 2005, Dong-A Pharm developed Udenafil (Zydena), which had been developed since 1998, as the first domestically produced product, and its price competitiveness was presented as an advantage. While it is a war of three types of erection stimulants, in Korea, five types of erection stimulants are engaged in a more intense local battle.

At this time, the highest dose began to be prescribed as the first dose along with pharmaceutical companies' marketing strategy to increase market share due to the safety already proven in many patients. The concept of the has disappeared.

Meanwhile, PDE5 inhibitor is present in the smooth muscle of almost all organs of the human body, and research results have been published in various fields due to the active route of the NO pathway. permission has been obtained For this reason, in 2005-2007, academia presented various evidence that could expand the treatment area of ​​PDE5 inhibitor, an oral erectile dysfunction drug, to diseases other than erectile dysfunction.

As demonstrated by Pfizer's Revatio, the new usage of PDE5-Is as an oral drug for erectile dysfunction is safe even after long-term administration. It can be applied to the treatment of factors.

[madeimpact]

Headcanon: Lucas, mind-reading, empathy, and how it affects his everyday life.

Lucas and Claus’s PSI abilities weren’t apparent from birth, the way they are in some of the other Mother party members. They definitely displayed some early signs of having some sort of special abilities, such as Lucas’s propensity for understanding animals even before he could literally understand them. But they weren’t, say, levitating objects straight out of the womb. Those overtly psychic abilities wouldn’t become apparent until after Ionia awoke it in both of them.

That being said, Lucas can read your mind...but unlike other, more experienced psionics, he has to actively do it. Rather than walking by and just hearing a conversation in passing, it’s more like having to open a door in order to hear what’s being said on the other side for him. Not exactly a huge amount of effort, but still a conscious activity. But generally, he doesn’t open that door unless a) he’s given permission, b) he opens a telepathic conversation first, or c) he reads the room and feels like it’s necessary.

What does come to Lucas fairly unconsciously, though, is the emotions of others. He was already very sensitive before having PSI; unlocking those abilities just made him more of an empath in a very literal sense. He’s adjusted to this sensation and can generally compartmentalize his feelings vs the feelings of others in very low-stakes situations. It’s when emotions run hot that this experience gets more intense for him.

Sticking with the door analogy, it’s as if he were to walk past a door and, while not being able to make out the exact words that are being said unless he actively tries, he can definitely pick up on the tone of what’s being said without much effort at all. Not a huge deal if it’s just mundane small talk happening on the other side of that door; he can just sort of acknowledge it and move along, or just let it slide through his subconscious mind. But if someone on the other side of the door was letting out giddy victory cries, or sobbing audibly, or having a heated argument with someone else — that’s when the emotions come to the forefront of his mind. It might be why he’s so good at being the shoulder to cry on, despite being so young.

The flip side is that, for such an emotional person, his PSI is especially susceptible to changes in his emotions. An especially potent PK Love fueled by a desperate desire to keep his friends safe; a PK Fire in a Smash match that burns especially hot with competitive spirit; an especially effective heal fueled by desperation not to lose anyone else; it’s all well within the realm of possibility for him.

All that said? You probably wouldn’t want to have seen what Lucas looked like when confronting Porky.