#cysteamine cream reviews

[yolandawakers-blog]

[complexion-me]

Review : Cyspera Intensive Pigment Corrector

What is it?

A novel pigment corrector that is hydroquinone free.

Who is it for?

Anyone looking to treat melasma, dark spots, pigmentation and post-inflammatory hyper pigmentation.

This is a hydroquinone-free option making it safe for long-term use.

What’s in it?

The main ingredient in this is 5% Cysteamine.

All Ingredients:

Aqua, Paraf num Liquidum, Cysteamine HCL, Niacinamide, Butyrospermum Parkii (Shea Butter), Lecithin, Glyceryl Stearate, Isopropyl Myristate, Cetyl Alcohol, Ascorbyl Palmitate, Ceteareth-20, Sodium Ascorbyl Phosphate, Octyldodecanol, Phenoxyethanol, Ethylhexylglycerin, Propylheptyl Caprylate, Ceteareth-12, Cetearyl Alcohol, Cetyl Palmitate, Parfum, Xanthan Gum, Peg-30 Dipolyhydroxystearate, Tocopherol, Cera Alba, BHT, Tetra Sodium EDTA, Hexyl Cinnamic Aldehyde, Linalool, Geraniol

How to use?

Cyspera  should be applied every night OR morning and then washed off. This should be applied on unwashed skin! And yes, it can penetrate through your light makeup and skincare. 

Do not wash skin before application.

Do not wash your face before application. If necessary to wash, wait one hour before application of Cyspera on a dry and rested skin. I personally applied this every morning.

Apply Cyspera for 15-20 minutes

Once a day as part of your morning/ evening routine, apply a thin layer of Cyspera to the full face. Leave on for 15 minutes only. I recommend working up to 20 minutes after 2 months.

Wash off.

After 15 mins, cleanse your skin thoroughly with a gentle cleanser and water. Gently pat your face dry.

Apply a moisturising cream or lotion.

What to expect?

A visible decrease in pigmentation and drastic results at the 12 week mark.

Pros

First & only skin pigment corrector containing cysteamine as ingredient

Intensive — clinically proven. Set to replace hydroquinone as the new standard for hyperpigmentation concerns

Safe — hydroquinone-free, retinoic acid free, kojic acid free, corticosteroid-free

Works on all skin tones

Won’t bleach normal toned skin

Safe to use all year round

Won’t cause additional photosensitvity

Readily available online (Prescription not required)

Can be combined with other actives

Cons

Short contact therapy can be labour intensive

Conclusion

Previously, the most common skin-depigmenting agent for the treatment of melasma and pigmentation had been hydroquinone. However, with growing fears over hydroquinone’s link to ochronsis when applied topically as well as carcinogenicity in animal studies, restrictions have been applied to its use in almost all worldwide markets. This has left dermatologists and patients seeking a new alternative. While I still feel hydroquinone is a safe option to consider when used under the supervision of a board certified dermatologist, it can’t be used long term which is why I typically prefer HQ-free options.

This can be easily combined with hydroquinone free options like azelaic acid and tranexamic acid. 

Cysteamine has been shown by researchers in laboratory studies to have significant de-pigmenting activity, but it has never been formulated into a cream due to its very unpleasant sulphur odour. Thankfully, Scientis has managed to develop a stabilized form with significantly reduced odour.

Clinical studies (links below) have shown Cyspera to be superior to traditional depigmenting creams such as Hydroquinone in treating melasma. It is also safer and gentler on human skin due to the fact that it is naturally occurring in human skin cells, and does not have carcinogenic (cancer-causing) potential in long-term use.

In fact, Cyspera’s been shown to treat recalcitrant melasma resistant to Kligman’s formula.

Cysteamine is a natural molecule with an excellent safety profile and known antimutagenic, antimelanoma, and anticarcinogenic effects. Considering the high efficacy of cysteamine cream, it’s definitely my favourite topical option for treating stubborn pigmentation.

While the short contact therapy can be labour intensive, it also means there’s a much lower risk of the topical inflaming the skin and causing pigmentation.

Sources:

Kasraee B. “Deodorized cysteamine* as a depigmenting agent for the treatment of melasma.”Pigment Cell Melanoma Research. 2017;30:e27–e137

Farshi S. et al. “Efficacy of Cysteamine Cream in the treatment of melasma.”Journal of Dermatological Treatment July 2017

Mansouri P. et al. “Evaluation of the efficacy of cysteamine 5% cream in the treatment of epidermal melasma: a randomized double-blind placebo-controlled trial.”British Journal of Dermatology (2015) 173, pp 209-217

Hsu C. et al. “Cysteamine cream as a new skin depigmenting product.”Journal of the American Academy of Dermatology (2013) 68:4-1 AB189

For more info or to purchase Cyspera Cream : cyspera.com

For UK : https://www.aestheticsource.com/pages/find-a-clinic

[vancejhiller]

Review : Cyspera Intensive Pigment Corrector

What is it?

A novel pigment corrector that is hydroquinone free.

Who is it for?

Anyone looking to treat melasma, dark spots, pigmentation and post-inflammatory hyper pigmentation.

This is a hydroquinone-free option making it safe for long-term use.

What’s in it?

The main ingredient in this is 5% Cysteamine.

All Ingredients:

Aqua, Paraf num Liquidum, Cysteamine HCL, Niacinamide, Butyrospermum Parkii (Shea Butter), Lecithin, Glyceryl Stearate, Isopropyl Myristate, Cetyl Alcohol, Ascorbyl Palmitate, Ceteareth-20, Sodium Ascorbyl Phosphate, Octyldodecanol, Phenoxyethanol, Ethylhexylglycerin, Propylheptyl Caprylate, Ceteareth-12, Cetearyl Alcohol, Cetyl Palmitate, Parfum, Xanthan Gum, Peg-30 Dipolyhydroxystearate, Tocopherol, Cera Alba, BHT, Tetra Sodium EDTA, Hexyl Cinnamic Aldehyde, Linalool, Geraniol

How to use?

Cyspera  should be applied every night OR morning and then washed off. This should be applied on unwashed skin! And yes, it can penetrate through your light makeup and skincare. 

Do not wash skin before application.

Do not wash your face before application. If necessary to wash, wait one hour before application of Cyspera on a dry and rested skin. I personally applied this every morning.

Apply Cyspera for 15-20 minutes

Once a day as part of your morning/ evening routine, apply a thin layer of Cyspera to the whole area to be treated. Leave on for 15 minutes only. I recommend working up to 20 minutes after 2 months.

Wash off.

After 15 mins, cleanse your skin thoroughly with a gentle cleanser and water. Gently pat your face dry.

Apply a moisturising cream or lotion.

What to expect?

A visible decrease in pigmentation and drastic results at the 12 week mark.

Pros

First & only skin pigment corrector containing cysteamine as ingredient

Intensive — clinically proven. Set to replace hydroquinone as the new standard for hyperpigmentation concerns

Safe — hydroquinone-free, retinoic acid free, kojic acid free, corticosteroid-free

Works on all skin tones

Won’t bleach normal toned skin

Safe to use all year round

Won’t cause additional photosensitvity

Readily available online (Prescription not required)

Can be combined with other actives

Cons

Short contact therapy can be labour intensive

Conclusion

Previously, the most common skin-depigmenting agent for the treatment of melasma and pigmentation had been hydroquinone. However, with growing fears over hydroquinone’s link to ochronsis when applied topically as well as carcinogenicity in animal studies, restrictions have been applied to its use in almost all worldwide markets. This has left dermatologists and patients seeking a new alternative. While I still feel hydroquinone is a safe option to consider when used under the supervision of a board certified dermatologist, it can’t be used long term which is why I typically prefer HQ-free options.

This can be easily combined with hydroquinone free options like azelaic acid and tranexamic acid. 

Cysteamine has been shown by researchers in laboratory studies to have significant de-pigmenting activity, but it has never been formulated into a cream due to its very unpleasant sulphur odour. Thankfully, Scientists Pharma has managed to develop a stabilized form with significantly reduced odour.

Clinical studies (links below) have shown Cyspera to be superior to traditional depigmenting creams such as Hydroquinone in treating melasma. It is also safer and gentler on human skin due to the fact that it is naturally occurring in human skin cells, and does not have carcinogenic (cancer-causing) potential in long-term use.

In fact, Cyspera’s been shown to treat recalcitrant melasma resistant to Kligman’s formula.

Cysteamine is a natural molecule with an excellent safety profile and known antimutagenic, antimelanoma, and anticarcinogenic effects. Considering the high efficacy of cysteamine cream, it’s definitely my favourite topical option for treating stubborn pigmentation.

While the short contact therapy can be labour intensive, it also means there’s a much lower risk of the topical inflaming the skin and causing pigmentation.

Sources:

Kasraee B. “Deodorized cysteamine* as a depigmenting agent for the treatment of melasma.”Pigment Cell Melanoma Research. 2017;30:e27–e137

Farshi S. et al. “Efficacy of Cysteamine Cream in the treatment of melasma.”Journal of Dermatological Treatment July 2017

Mansouri P. et al. “Evaluation of the efficacy of cysteamine 5% cream in the treatment of epidermal melasma: a randomized double-blind placebo-controlled trial.”British Journal of Dermatology (2015) 173, pp 209-217

Hsu C. et al. “Cysteamine cream as a new skin depigmenting product.”Journal of the American Academy of Dermatology (2013) 68:4-1 AB189

For more info or to purchase Cyspera Cream : cyspera.com

For UK : https://www.aestheticsource.com/pages/find-a-clinic

Review : Cyspera Intensive Pigment Corrector -- read full story here: https://complexion-me.tumblr.com/post/624004707660218368

[complexion-me]

Interview : Dr Heidi Waldorf, Dermatologist

Dr Heidi A Waldorf, MD is a nationally and internationally respected expert and sought after lecturer in the field of Dermatology and Cosmetic Medicine, including skin rejuvenation, soft tissue augmentation, cosmetic use of botulinum toxin, noninvasive fat reduction, laser and other energy based device technology and cosmeceuticals.

Dr. Waldorf completed her undergraduate and medical education and training at Harvard University and the University of Pennsylvania, after which she completed a fellowship in Mohs Micrographic Surgery, Laser Surgery and Cosmetic Dermatologic Surgery.  Former Director of Laser and Cosmetic Dermatology at Mount Sinai Hospital in New York for two decades, Dr Waldorf now sees patients exclusively at her private practice Waldorf Dermatology Aesthetics in Nanuet, NY.

1) Tell us a bit about your background. How did you choose dermatology as your speciality? 

My dad was not subtle in ‘suggesting’ I be a derm:  “pass the potatoes – have I told you that dermatology is a wonderful career”.  So if anything, I decided I would be anything but a dermatologist.  But it must be genetic – my dad, the derm, + my late mom, an artist before she became a lawyer = me, very visual and spatially oriented and good with my hands. Plus I love seeing patients of all ages and working with the tangible.  So despite going to medical school thinking I’d go into public policy (my college major was economics and I wrote my honors thesis on the tobacco industry), I decided on dermatology.  My subspecialty evolved as I went through training – first bench work research, then dermatologic surgery, then lasers and so on.  What is interesting is that most of what I do in practice today was not available when I came out of fellowship in 1995.  But it shows the importance of completing a residency and fellowship and becoming board certified in a core cosmetic field (dermatologic surgery, plastic surgery, facial plastics and oculoplastics).  Because of my background in skin pathophysiology and facial anatomy, I was able to grow with the field.  Aesthetics is my passion clinically and academically.  I spend the time lecturing, training and helping develop new treatments because I believe strongly that it can and should always be done safely, ethically and with a natural appearing outcome.

2) What do you feel are the most commonly made mistakes in skin care? How do you feel these can best be avoided?  

Too much – too often is a common mistake in skincare for everything except sunscreen (which people tend to use too little and too infrequently).  What I mean is people over use products thinking that more is better.  When scaley they exfoliate – they are smooth for a day then scaley again and exfoliate more and so on.  If they’d consulted a dermatologist, they’d have learned that exfoliation without moisturization doesn’t give longlasting results.  If skin doesn’t turn over normally itself – due to photodamage, use of a retinoid or dermatologic condition – then exfoliating physically or chemically is helpful.  But the only way to get at the root of the issue is to hydrate and seal in that moisture after exfoliating.  Retinoids are another common example.  Every dermatologist will tell you that there is more science on retinoids to treat aging and photoaging than any other category of ingredient.  However, they can irritate.  It is important to ease into use – twice a week to three times a week etc , start with lower rather than higher concentrations, and moisturize with it.  

3) Your skin’s always so glowy! Could you walk us through your skincare routine? 

My skincare routine is simple – because at 54, I still have no sun damage.  In the morning, I wash with Neostrata exfoliating foaming cleanser for my face and Dove body wash for my body in the shower.  Then I apply Caudalie body butter to my arms, legs and wherever else I feel dry on my body, Dermatopix intensive hand cream to my hands and  Caudalie premier cru crème riche, to my face and neck I follow with ISDIN Eryfotona Actinica sunscreen for face, neck, arms – whatever might be exposed.  During the summer months when I don’t need as much moisturization and have more of my arms and legs exposed, I often skip the caudalie moisturizers and just use the Eryfotona Actinica for my face and neck and Elta UV Lotion for my arms and legs.  At night, I apply Vaseline or bag balm to my lips and Dermatopix to my hands and feet.  I do nothing else – at most I will wipe my face with a pre-moistened towelette by Neutrogena, Simple or Garnier and apply some of the crème riche but most nights I don’t even wash my face.  I can do that because I don’t wear foundation and have no tendency for acne. I have My Pillow pillows that don’t fight against my face and use Illuminage and Slip pillowcases and eye masks  – Illuminage contains copper fibers which are antibacterial and rejenerative and Slip silk fabric keeps your face from sticking to it and forming sleep lines.

4) It’s said that pigmentation’s become the new wrinkle. What are your thoughts on the safety profile on hydroquinone? 

Hydroquinone is very safe when used in appropriate concentrations and for limited periods of time.  The limitation of hydroquinone is irritation from topical use and the inability to use during pregnancy, a time when many women develop hyperpigmentation.  As a dermatologist, pigmentation has always been a biggie for my practice – it goes hand in hand with wrinkling in photodamage and in patients with melasma.  

5) You recently mentioned Cysteamine's to be a new product on the market that's said to be a great option for treating melasma and pigment issues. Could you tell us more about how it works? 

Cysteamine is interesting because this active ingredient was actually discovered in the 1960’s at the same time as hydroquinone.  But there were manufacturing issues limiting its use until recently.  Like hydroquinone, cysteamine reduces melanin in the epidermis by blocking the process of melanogenesis.  The key advantage over hydroquinone is that it can be used during pregnancy without concern.  That allows patients to use it during a time when pigment is a particular concern.  I also find it useful for patients who have used hydroquinone (usually as part of the Kligman formula with a corticosteroid and retinoid) for months to years and plateau’d.  Switching to cysteamine allows them to get further meaningful improvement.  They can use it alone or alternate night with a retinoid or alpha hydroxy acid.  Note that using cysteamine does not remove the importance of sun protection which is always a critical part of any pigmentation treatment.

6) What has been the greatest difficulty you have encountered in starting and maintaining your own successful dermatology practice? In the skin care business? 

Time.  There’s never enough of it.  I love treating patients, working with my staff, lecturing at aesthetic dermatology and multispecialty meetings, consulting with industry to help develop new treatment protocols, reviewing papers for peer reviewed journals and doing my #heideas videos for the public and editorials for the journals I edit.  I love traveling for work and play.  And there’s the ‘life scut’ required to administer a practice and live a life, not to mention time with family, friends and myself.  Something’s gotta give.  After years of feeling overwhelmed I received a present from a friend - a ‘no’ button.  And that’s been the key to balance - learning to say ‘no’ to the things/experiences that aren’t necessary, enjoyable and/or that add to my life as a physician or person.

7) Are you loyal to any pro services or treatments?  

Yes. When someone or something works, I don’t see the need to switch.  Beth Minardi has colored my hair for over 20 years - before and after I lost it to chemotherapy (and she helped me get my wig!).  Sachiko Fukumoto has cut my hair for that same time.   Lysette Drumgold has done my blowouts and makeup for events for a decade. I do my own tox but filler is trickier.  There are only 4 or 5 people I’ve let do my filler when I can’t reach - we do it when I see them at meetings.  And my staff does my coolsculpting, emsculpt and thermage!

8) Lastly, for someone just starting to think about how to age gracefully, what is the best advice you can offer in terms of maintenance and prevention? 

I can’t  overemphasize my big 3: don’t smoke, don’t pick and DO protect against ultraviolet light!!!  And see a board certified cosmetic dermatologist who specializes in noninvasive rejuvenation and at the same time is specialty trained to recognize things that should not be treated aesthetically like malignancies.  This isn’t like getting a blow out or massage - avoid the groupon crowd and don’t doctor shop based on price.  Better to get less done but done well and safely.  And develop a relationship with that doctor that allows her to know your needs and what works for you over the long term.  Then you can grow old looking young together.

Credits

https://waldorfderm.com

https://www.instagram.com/drheidiwaldorf/

https://www.facebook.com/heidiwaldorfmd/