#Type 2 Diabetes Medicine

[reasonsforhope]

A new treatment combining ReCET and semaglutide could eliminate the need for insulin in type 2 diabetes, with 86% of participants in a study no longer requiring insulin therapy. The treatment was safe and well-tolerated, and further trials are planned to confirm these results.

Groundbreaking research presented at UEG Week 2024 introduces a promising new treatment approach for type 2 diabetes (T2D) that has the potential to greatly reduce or even eliminate the need for insulin therapy.

This innovative approach, which combines a novel procedure known as ReCET (Re-Cellularization via Electroporation Therapy) with semaglutide, resulted in the elimination of insulin therapy for 86% of patients.

Globally, T2D affects 422 million people... While insulin therapy is commonly used to manage blood sugar levels in T2D patients, it can result in side effects... and further complicate diabetes management. [Note: Also very importantly it's fucking bankrupting people who need it!!] A need therefore exists for alternative treatment strategies.

Study Design and Outcomes

The first-in-human study included 14 participants aged 28 to 75 years, with body mass indices ranging from 24 to 40 kg/m². Each participant underwent the ReCET procedure under deep sedation, a treatment intended to improve the body’s sensitivity to its own insulin. Following the procedure, participants adhered to a two-week isocaloric liquid diet, after which semaglutide was gradually titrated up to 1mg/week.

Remarkably, at the 6- and 12-month follow-up, 86% of participants (12 out of 14) no longer required insulin therapy, and this success continued through the 24-month follow-up. In these cases, all patients maintained glycaemic control, with HbA1c levels remaining below 7.5%.

Tolerability and Safety

The maximum dose of semaglutide was well-tolerated by 93% of participants, one individual could not increase to the maximum dose due to nausea. All patients successfully completed the ReCET procedure, and no serious adverse effects were reported.

Dr Celine Busch, lead author of the study, commented, “These findings are very encouraging, suggesting that ReCET is a safe and feasible procedure that, when combined with semaglutide, can effectively eliminate the need for insulin therapy.”

“Unlike drug therapy, which requires daily medication adherence, ReCET is compliance-free [meaning: you don't have to take it every day], addressing the critical issue of ongoing patient adherence in the management of T2D. In addition, the treatment is disease-modifying: it improves the patient’s sensitivity to their own (endogenous) insulin, tackling the root cause of the disease, as opposed to currently available drug therapies, that are at best disease-controlling.”

Looking ahead, the researchers plan to conduct larger randomized controlled trials to further validate these findings. Dr. Busch added, “We are currently conducting the EMINENT-2 trial with the same inclusion and exclusion criteria and administration of semaglutide, but with either a sham procedure or ReCET. This study will also include mechanistic assessments to evaluate the underlying mechanism of ReCET.”

-via SciTechDaily, October 17, 2024

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Note: If it works even half as well as suggested, this could free so many people from the burden of the ongoing ridiculous cost of insulin. Pharma companies that make insulin can go choke (hopefully).

[panchgavyasupplements]

Introduction to Diabetes and Types  

Studies have shown that India ranks second after China in the global diabetes epidemic, with 77 million people with diabetes. Of these, 12.1 million are aged >65 years, which is estimated to increase to 27.5 million in the year 2045. There are two most common types of diabetes: Type 1 diabetes and Type 2 diabetes

With Type 1 diabetes, the body stops producing insulin as the insulin-producing cells in the pancreas are destroyed. In this condition, a person must take insulin injections daily to regulate blood glucose levels.

Type 2 diabetes is a serious disease where your body may not respond to insulin, or the body makes insulin but not enough or does not use it well, and thus the sugar levels could go haywire. Thus, sugar steadily builds up in the blood, eventually leading to the blood vessels hardening, causing heart attacks, kidney failure, and stroke.

What are the risk factors for type 2 diabetes?

Risk factors that can increase diabetes include

obesity and a sedentary lifestyle,

uncontrolled blood glucose synthesis in the liver,

hereditary causes

Dysfunctional beta-cell in the pancreas

What are the symptoms of Type 2 diabetes?

You may have diabetes if you have

Blooded vision

Frequent urination

Increased hunger

Slowed healing of wounds, red, swollen, tender gums, and

Tingling hands and feet. If you experience such symptoms, consult your doctor immediately.

What are the complications of Type 2 Diabetes?

Long-term untreated diabetes affects the nerve, kidneys, heart, and eyes.

Nerve damage: Diabetes damages the nerves in the legs and arms. These cause numbness, pain, and tingling that start with the fingers and toes and spread along the legs. If this is left untreated, a person can lose all sense of feeling. Diabetic neuropathy is a family of progressive nerve disorders.

Kidney damage: Long-term uncontrolled blood sugar leads to kidney failure that requires dialysis or a kidney transplant.

Heart and blood vessels: For people with diabetes, who have high blood glucose cause blood vessels in the body to become damaged; when this happens, plaque can form in the blood vessels, making it difficult for the blood to flow.

Eye damage: Diabetes, if left untreated, can damage the retina of the eyes, which may lead to blindness.

Nutrients and vitamins:

Diabetic patients tend to have less nutrient absorption for vitamins like Vit C, D3, calcium, and Vit, herbs. Defective insulin secretion and insulin sensitivity cause metabolic disorders.

Ayurvedic Approach for Type 2 Diabetes

In Ayurveda, diabetes is described as ‘Madhumeha’. Diabetes mellitus is described as Vaat Pramehaand Diabetes insipidus is described as Kaph Prameha

According to Ayurveda, imbalances of kaph dosh, pitt dosh together with vaat dosh are the main cause of Madumeha. Vaat, kaph, and Pitt block the pathways connected to the mamsa (muscle) and meda (fat) tissues.

Eating too much, not exercising, being overweight—all these factors aggravate the vaat dosh of the body, where the body does not make enough insulin or does not use it well, and that leads to diabetes.

Ayurveda suggests Jamun and its seeds are highly effective herbs against diabetes. Known as jamboline and jambosine, the fruit seeds slow down the release of sugar into the bloodstream and increase insulin levels. Diabetes symptoms such as frequent urination and thrusting can be reduced with it since it converts starch into energy. In addition to reducing serum glucose levels and insulin resistance, the herb also reduces dyslipidemia and enhances the function of B cells. As a result, the herb rejuvenates the pancreatic cells at the cellular level.

What is the Treatment for Type 2 Diabetes?

Treatment of type 2 diabetes focus on the combination of diet and lifestyle changes along with medicines.

Lifestyle changes: Yoga has shown to be a great option in the treatment of diabetes. Regularly practising yoga can help to control blood sugar and increase insulin sensitivity in the cells. In addition to helping reduce blood sugar, yoga benefits by reducing stress levels and reducing the risk of heart problems by protecting cardiac health. Regular yoga helps to improve nerve function and boost metabolism, thereby improving nerve health.

Diet changes: It is recommended to consume low-fat foods, avoid any dairy-based products, and incorporate certain foods, such as bitter ground, Bengal gram, and fenugreek seeds, to control blood sugar.

Blood sugar monitoring:  Regular blood sugar monitoring is beneficial in the treatment of type 2 diabetes.

Medication:

Although it is now one of the most common yet challenging health issues that people face, a rooted approach plus modern technology provide Meta medicine in the form of DiabGavyam, which is effective and consists of some of the best herbs for the treatment of type 2 diabetes.

DiabGavyam activates the pancreas, stimulates the secretion of a balanced amount of insulin, and regulates the metabolism of carbohydrates. The formulation is blended with the herbs Jamun Beej, and Madhunashak that protect the nerve cells in the retina, thus fortifying the blood vessel, and promoting blood circulation, thus lowering the chance of diabetic retinopathy.

While medicine helps in the control of blood sugar; it does not have any side effects after taking a tablet. You can take 1 or 2 tablets twice a day or as directed by your physician.

[girlivealwaysbean]

mann im going to get my blood reports tomorrow and im lwk scared

[mindblowingscience]

A drug commonly used to treat type 2 diabetes could also effectively protect against colorectal cancer (CRC), based on a new analysis by researchers in the US. The drug in question is a class of medications known as glucagon-like peptide-1 receptor agonists – more easily referred to as GLP-1 RAs. These medications, which include the widely-known 'wonder drug' sold under the commercial name Wegovy, have also previously been linked to weight loss and reducing the risk of cardiovascular problems.

Continue Reading.

[the-kestrels-feather]

I hope all of the people using Ozempic and Mounjaro to lose weight without a perscription and the celebrities having fucking "Ozempic and Mounjaro Parties" are enjoying it because I (a person who actually needs it for diabetes management and has a perscription) am about to miss my 3rd week of shots because I've called 3 pharmiacies and not a single one has it.

[wikipediapictures]

Insulin (medication)

[emmanueljonezblog]

New Diabetes Cure 😲

🔥 The Blood Sugar Breakthrough Everyone’s Talking About! 💡 Say goodbye to restrictions and hello to freedom. This 14-second trick is changing how people manage their blood sugar—no meds, no endless diets, just RESULTS. ✨ What makes it different? ✅ It’s natural, effortless, and doctor-approved. ✅ It tackles the real problem, not just symptoms. ✅ You can enjoy the foods you love without guilt! 🎥 Don’t wait—watch the video NOW before it’s gone forever! 👇 Transform Your Health Today! 👇 https://www.vitaliswell.com/native

[c3s6]

[angrydino42-and-avathecannibal]

is this the only way i can spread information

[med4lif3]

Diabetes (research post)

Diabetes is a chronic disease of varying types in which issues occur with insulin production or regulation

How's it caused?:

Type 1 diabetes: A chronic condition in which the pancreas produces an insufficient to none amount of insulin (hormone that allows glucose to be processed and enter into cells to create energy).

Type 2 and prediabetes: Similar to type 1 diabetes, the pancreas fails to produce enough insulin and the body is unable to use insulin which eventually leads to high levels of blood sugar. 

Gestational diabetes: This type of diabetes occurs in pregnant women and its cause is unknown. It has been theorized that the placenta will produce hormones that prohibit the mother's ability to regulate and use insulin.

Symptoms?:

Increased thirst

Frequent urination

Increased hunger 

Fatigue

Slow healing sores

Genital itching (Gestational diabetes

Treatment?:

For type 1 diabetes patients, they're treated with doses of insulin either by a daily injection or an insulin pump.

For type 2 diabetes patients are encouraged to lose weight and exercise, keeping their diet in check as type 2 diabetes is linked to obesity. Diabetes medications (such as ozempic) or insulin therapy may be given if dietary changes and exercise are insufficient in managing blood sugar.

Similarly patients with gestational diabetes manage the disease either through a healthier diet and exercise or insulin depending on their progression.

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Note: this one resonates a bit since my country (lol the us) is well known for our high rates of diabetics and it also runs in my family but to keep things lighthearted i remade this meme i saw a while ago w my own twist

[livehealthyandhappy]

Discover the secrets to control your blood sugar and transform your life. Want to start living healthy click here

[panchgavyasupplements]

DiabGavyam - Diabetes Controller

[mindblowingscience]

Frequently adding salt to foods was associated with an increased risk of developing type 2 diabetes in a new study. People at risk for type 2 diabetes may already know to avoid sugar, but the study suggests they may want to skip the salt as well. The study in Mayo Clinic Proceedings surveyed more than 400,000 adults registered in the UK Biobank about their salt intake. Over a median of 11.8 years of follow-up, more than 13,000 cases of type 2 diabetes developed among participants. Compared to those who “never” or “rarely” used salt, participants who “sometimes,” “usually,” or “always” added salt had a respective 13%, 20%, and 39% higher risk of developing type 2 diabetes. “We already know that limiting salt can reduce the risk of cardiovascular diseases and hypertension, but this study shows for the first time that taking the saltshaker off the table can help prevent type 2 diabetes as well,” says lead author Lu Qi, professor at the Tulane University School of Public Health and Tropical Medicine.

Continue Reading.

[wikipediapictures]

Insulin (medication)

[quotesfrommyreading]

Several countries, including Pakistan, Egypt, Bangladesh, India, Turkey, the Philippines and China, have been identified as centres of organ trafficking, but the trade in organs is a transnational operation. In its 2018 Global Report for Trafficking in Persons, the United Nations Office on Drugs and Crime identified more than 700 cases of organ trafficking, the majority in the Middle East and north Africa. A 2021 Interpol report claimed that organ trafficking was of particular concern in north and west Africa, “where impoverished communities and displaced populations are at greater risk of exploitation”.

According to the Global Observatory on Donation and Transplantation (GODT), only 10% of the global demand for transplants is met each year. Increased demand for kidney transplants, in particular, has been exacerbated by a shortage of altruistic donations and limited access to transplant services. This has led to an increased dependence on criminal networks that obtain organs from vulnerable individuals.

There is a black market for organs including kidneys, corneas and liver lobes. Rising demand for kidneys is partly a result of the spread of so-called diseases of affluence – diabetes, hypertension, obesity – and the subsequent rise in kidney failure. According to the charity Kidney Care, in the UK, the waiting list for a kidney transplant has increased dramatically since the pandemic. Consequently, more people are travelling overseas for transplant surgery. In many countries that attract transplant tourists, kidneys are sourced from the bodies of the poor and disenfranchised.

As a legal academic, I have been investigating the global trade in organs since 2014. Over the past 10 years, I have spoken to 43 people from Sudan, South Sudan and Eritrea who sold a kidney out of economic necessity. In most cases, people were targeted by criminal groups because of their precarious status as asylum seekers, refugees or undocumented migrants. Most were not paid what they were promised. Some were paid nothing. Doubly criminalised, as illegal migrants and organ sellers, they were in no position to negotiate a price, or to ensure they got paid the agreed amount. Because of their precarious legal status they were also less likely to report abuse to the authorities.

In the absence of legal pathways to migration, many had sold their kidneys after they had been arrested, detained and in some cases deported back to countries where their lives were under threat. Most had opted to avoid refugee camps, describing them as “prisons” and “death camps” where people go to die. They were disillusioned with the United Nations Refugee Agency (UNHCR). It was better to risk crossing the Sahara, Yonas told me, than to live under permanent surveillance, captive and dependent on a broken asylum system. Many, like Yonas, had expended all their resources trying to reach Europe and claim asylum. Categorised as illegal and pushed to the margins of society, they were exposed to exploitation of different kinds.

The illicit networks that supply organ markets depend on the close cooperation of medical doctors. Criminal intermediaries are involved in the negotiation of fees, and the preparation of official-looking paperwork presented as evidence of informed consent to an altruistic donation. These brokers, who connect sick patients with impoverished and vulnerable “donors”, also form long-term partnerships with medical professionals. Without the involvement of surgeons who perform illegal transplants for profit, the trade in organs would cease to exist.

In March 2023, the UK tried its first organ-trafficking case. A Nigerian politician, his wife and their broker were found guilty of conspiring to bring a man to the UK from Lagos to obtain his kidney for transplant. The judge said in sentencing: “The trafficking of people across international borders to harvest their organs is a form of slavery. It treats human beings, and their body parts, as commodities to be bought and sold. It is a trade that preys on human poverty, misery and desperation.” Unfortunately, as war and climate crisis displaces more people, there is no shortage of desperate people to prey on.

  —  ‘For me, there was no other choice’: inside the global illegal organ trade