#Sequencing

[cbirt]

In order to establish standardized high-throughput whole-genome sequencing (WGS) for patients with cancer and rare diseases, the UK Government launched the groundbreaking 100,000 Genomes Project within the National Health Service (NHS) in England. This was accomplished through the use of an automated bioinformatics pipeline accredited by the International Organisation for Standardisation. Operating in conjunction with NHS England, Genomics England examined WGS data from 13,880 solid tumors representing 33 different cancer types, fusing genetic information with actual treatment and outcome data in a secure research environment. 

WGS and longitudinal life course clinical data were linked, enabling the evaluation of treatment results for patients categorized by pangenomic markers. The results of this study show how useful it is to connect genomic and practical clinical data in order to do survival analysis, locate cancer genes that influence prognosis, and deepen our knowledge of how cancer genomics affects patient outcomes.

Using an automated bioinformatics pipeline accredited by the International Organisation for Standardisation, the 100,000 Genomes Project was a ground-breaking UK Government initiative implemented within the National Health Service (NHS) in England with the goal of establishing standardized high-throughput whole-genome sequencing (WGS) for patients with cancer and rare diseases.

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[grrlmusic]

C2H4

[everythingaboutbiotech]

Common uses of bioinformatics

💡Sequence analysis Analyzing DNA and protein sequences to identify genes, regulatory regions & mutations.

💡Gene expression Analyzing RNA expression data from experiments like microarrays or RNA-seq to understand gene regulation.

💡Phylogenetics Constructing evolutionary relationships between organisms based on genetic data and genomic comparisons.

💡Molecular modeling Predicting protein structure and docking drugs to proteins using computational modeling and simulation.

💡Databases & Data mining Developing databases like GenBank to store biological data and mining it to find patterns.

💡Genomics Studying entire genomes, including sequencing and assembling genomes as well as identifying genes and genomic variations.

Follow @everythingaboutbiotech for useful posts.

[jewishdragon]

When a computer slows down bc its processing a shit ton of sequencing data i say "gotta be patient, the computer is doing a big thinkie"

[valvesoftware]

hi guys (covered in blood)

[valvesoftware]

:/

Gordon Ramsey fursona reveal!

[and-corn]

are evil dragons really evil, or are they just vitamin D deficient?

(pt 2)

[news-buzz]

NIS-Seq permits cell-type-agnostic optical perturbation screening

CROPseq-iT7 spine CROPseq-Information-Puro8, which was a present from Christoph Bock (Addgene, 86708), was PCR amplified with primers CROPseq_iT7_fwd/rev utilizing Q5 polymerase. PCR merchandise had been DpnI digested, 5′ phosphorylated and circularized by T4 ligation. Transformants had been sequence verified utilizing Tn5-mediated whole-plasmid tagmentation and MiSeq sequencing. The…

[miikpal]

24 ribs

[health-views-updates]

Sequencing Market Revenue, Demand & Top Players Forecast 2024-2032

The Sequencing Market Revenue was valued at USD 13.0 billion in 2023 and is expected to reach an impressive USD 47.29 billion by 2032, exhibiting a robust CAGR of 15.40% during the forecast period of 2024-2032. The rapid advancements in genomic research, coupled with the growing demand for precision medicine, are driving the adoption of sequencing technologies across various sectors, including healthcare, agriculture, and biotechnology.

Key Growth Drivers

The sequencing market is witnessing substantial growth due to the increasing prevalence of genetic disorders, rising cancer cases, and the growing awareness of the benefits of early and accurate diagnostics. Sequencing technologies, such as next-generation sequencing (NGS) and third-generation sequencing, are enabling researchers to decode genetic information faster and more accurately, leading to groundbreaking discoveries and improved treatment outcomes.

Furthermore, the adoption of sequencing in personalized medicine is transforming the healthcare landscape. By tailoring treatment plans based on individual genetic profiles, healthcare providers can offer more effective and targeted therapies. Additionally, the integration of sequencing technologies in agriculture for crop improvement and disease resistance is further fueling market expansion.

Regional Insights

North America dominates the sequencing market, driven by extensive investments in research and development, advanced healthcare infrastructure, and favorable government initiatives. The Asia-Pacific region, on the other hand, is poised for significant growth due to increasing healthcare expenditure, rising demand for precision medicine, and advancements in genomic research across countries like China, Japan, and India.

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Technological Advancements

Continuous innovation in sequencing technologies is expected to propel market growth further. The development of portable and real-time sequencing devices is making sequencing more accessible and affordable for smaller laboratories and research institutions. Additionally, the integration of artificial intelligence (AI) and machine learning (ML) is enhancing data analysis, enabling researchers to draw more meaningful insights from sequencing data.

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[beif0ngs]

I had a different name back then, you know. Powder. You kind of remind me of her.

[cbirt]

Suppose there was a library where the whole instruction manual for every living organism on Earth could be found. It’s not science fiction, but projects such as “Indexing All Life’s Known Biological Sequences” are designed to try and accomplish this. In this case, the instructions refer to DNA and protein sequences that constitute the blueprints of life. Decoding these sequences is necessary to understand how organisms function, evolve, and relate to each other. However, searching and analyzing these sequences has become difficult due to increased biological data being generated. This is where MetaGraph comes in – a powerful new tool that functions like Google for DNA, which was developed by researchers to tackle the problem of managing massive biological sequence datasets.

Our genetic information is written using nucleotides, which are essentially building blocks of RNA and DNA. Each living thing has its own set of these nucleotides arranged in an elaborate labyrinthine codebook. MetaGraph uses “De Bruijn graphs,” a smart strategy for representing these sequences efficiently. Think about it like a detailed map where each part represents a short sequence (called k-mer) while connections between sections show overlap between those k-mers.

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[pathologylab]

As we approach #MEDICA 2024, we’re thrilled to showcase our latest innovations in #diagnostics! Join us in Düsseldorf from November 11-14 at booth #H1/F23 to explore our advanced solutions in point-of-care #testing, #NGS clinical panels, Real-Time #PCR, and nucleic acid extraction solutions. 

Don’t miss the chance to discuss the future of diagnostic #healthcare with our team.

🤝 : Dusseldorf, Germany

📅 : November 11–14, 2024

🏪 : H1/F23

🌍 : https://www.genes2me.com/upcoming-events

Scan the QR code to book your meeting slots, or click here!

#MEDICA2024 #HealthcareInnovation #MolecularDiagnostics #G2M #conference #exhibition #nucleicacid #nucleic #solutions #rtpcr #Dusseldorf #nextgenerationsequencing #sequencing

[everythingaboutbiotech]

Looking to enhance your bioinformatics skills and take your research to the next level? Look no further than justbio - your one-stop-shop for all things bioinformatics!

[valvesoftware]

sigh.

there was also this which i am. very not sure qualifies as harassment

[moondvncer]

MY HEART JUST MELTED OH MY GOD

🥺🥹😭🤧🥹😭