#Protease inhibitor

[sophsweet]

How Philanthropists hijacked COVID-19

Since early 2020, some observant people have speculated about where all the money committed by the Gates Foundation in January 2020 was going. The Bill and Melinda Gates website proudly announce their work to fight covid-19 from January 2020. How did they know how Coronavirus Disease 2019 would cause a global pandemic? Defensive institutes such as the main subject of this blog, patronisingly…

[drpedi07]

Atazanavir Drug

Medical information for Atazanavir on Pediatric Oncall including Mechanism, Indication, Contraindications, Dosing, Adverse Effect, Interaction, Renal Dose, Hepatic Dose

[drpedi07]

Amprenavir Drug

Medical information for Amprenavir on Pediatric Oncall including Mechanism, Indication, Contraindications, Dosing, Adverse Effect, Interaction, Renal Dose, Hepatic Dose.

[neil-gaiman]

Hi Neil,

I’ve just realised something.

In Good Omens, Pollution is a horseperson of the apocalypse instead of Pestilence.

The novel was published in 1990 at the height of the AIDS crisis.

At the time, did you think about how that creative choice would resonate in the context of that particular pestilence? Also, are there ways in which echoes of the AIDS crisis appear in Good Omens? 

[These are genuine, non-judgmental questions. I’m too young to have experienced the pre-protease inhibitor era of the AIDS crisis. But I know it was a time of unimaginable tragedy in creative professions, exacerbated by institutional neglect and suffering. So writing at that time must have been fraught in complex ways. Thanks for your insights]

You might have forgotten the whole quote:

Pollution removed his helmet and shook out his long white hair. He had taken over when Pestilence, muttering about penicillin, had retired in 1936. If only the old boy had known what opportunities the future had held…

You'll find a fair amount of writing about what it was like working and living through that time, and why I created the Death Talks About Life public service comic here in this blog on Tumblr.

[hegory-grousing]

House felt Wilson’s light laugh. It vibrated through Wilson’s chest and into House’s shoulder, ending in an exhale against his neck. House barely repressed a shiver. “I really thought you’d given up this freaky little fetish,” House said. “I’ve been into the hug-stuff my whole life. Not stopping now.” “And you won’t rest until you’ve dragged the rest of us down with you and your vile habit.” “Exactly. Now, what were you going to tell me about protease inhibitors?” - Experimental Procedures by ORiley42 on Ao3

silly image I made of a bit from one of my absolute favorite house fics, Experimental Procedures by @oriley42. go read it it's fucking phenomenal

[covid-safer-hotties]

Also preserved on our archive

By Mary Van Beusekom, MS

SARS-CoV-2, the virus that causes COVID-19, is more infectious than severe acute respiratory syndrome (SARS) and Middle East respiratory syndrome (MERS) viruses because it contains an enzyme that can efficiently circumvent a host cell's innate defense mechanism, Kobe University–led researchers in Japan suggest in the Journal of Virology.

The innate immune system attaches the molecular tag ISG15 to SARS-CoV-2's nucleocapsid protein, which contains the virus's genetic material, inhibiting viral replication. The team's laboratory experiments suggest that the virus's papain-like protease (PLpro) can remove the tag, recovering its ability to assemble new viruses and escape the innate immune response.

Discovery may lead to more effective drugs While the SARS and MERS viruses belong to the same virus family and also have an enzyme that can remove the ISG15 tag, their versions are less efficient and have a different primary target than that of SARS-CoV-2.

In a Kobe University news release today, senior author Ikuo Shoji, MD, PhD, said this finding may help guide the development of more effective and selective COVID-19 inhibitors that target SARS-CoV-2's nucleocapsid protein.

"We may be able to develop new antiviral drugs if we can inhibit the function of the viral enzyme that removes the ISG15 tag," he said. "Future therapeutic strategies may also include antiviral agents that directly target the nucleocapsid protein, or a combination of these two approaches."

Study Link: journals.asm.org/doi/10.1128/jvi.00855-24

Press Release: www.eurekalert.org/news-releases/1061645