#Protease inhibitor

[sophsweet]

How Philanthropists hijacked COVID-19

Since early 2020, some observant people have speculated about where all the money committed by the Gates Foundation in January 2020 was going. The Bill and Melinda Gates website proudly announce their work to fight covid-19 from January 2020. How did they know how Coronavirus Disease 2019 would cause a global pandemic? Defensive institutes such as the main subject of this blog, patronisingly…

[drpedi07]

Atazanavir Drug

Medical information for Atazanavir on Pediatric Oncall including Mechanism, Indication, Contraindications, Dosing, Adverse Effect, Interaction, Renal Dose, Hepatic Dose

[drpedi07]

Amprenavir Drug

Medical information for Amprenavir on Pediatric Oncall including Mechanism, Indication, Contraindications, Dosing, Adverse Effect, Interaction, Renal Dose, Hepatic Dose.

[neil-gaiman]

Hi Neil,

I’ve just realised something.

In Good Omens, Pollution is a horseperson of the apocalypse instead of Pestilence.

The novel was published in 1990 at the height of the AIDS crisis.

At the time, did you think about how that creative choice would resonate in the context of that particular pestilence? Also, are there ways in which echoes of the AIDS crisis appear in Good Omens? 

[These are genuine, non-judgmental questions. I’m too young to have experienced the pre-protease inhibitor era of the AIDS crisis. But I know it was a time of unimaginable tragedy in creative professions, exacerbated by institutional neglect and suffering. So writing at that time must have been fraught in complex ways. Thanks for your insights]

You might have forgotten the whole quote:

Pollution removed his helmet and shook out his long white hair. He had taken over when Pestilence, muttering about penicillin, had retired in 1936. If only the old boy had known what opportunities the future had held…

You'll find a fair amount of writing about what it was like working and living through that time, and why I created the Death Talks About Life public service comic here in this blog on Tumblr.

[hegory-grousing]

House felt Wilson’s light laugh. It vibrated through Wilson’s chest and into House’s shoulder, ending in an exhale against his neck. House barely repressed a shiver. “I really thought you’d given up this freaky little fetish,” House said. “I’ve been into the hug-stuff my whole life. Not stopping now.” “And you won’t rest until you’ve dragged the rest of us down with you and your vile habit.” “Exactly. Now, what were you going to tell me about protease inhibitors?” - Experimental Procedures by ORiley42 on Ao3

silly image I made of a bit from one of my absolute favorite house fics, Experimental Procedures by @oriley42. go read it it's fucking phenomenal

[covid-safer-hotties]

Also preserved on our archive

By Mary Van Beusekom, MS

SARS-CoV-2, the virus that causes COVID-19, is more infectious than severe acute respiratory syndrome (SARS) and Middle East respiratory syndrome (MERS) viruses because it contains an enzyme that can efficiently circumvent a host cell's innate defense mechanism, Kobe University–led researchers in Japan suggest in the Journal of Virology.

The innate immune system attaches the molecular tag ISG15 to SARS-CoV-2's nucleocapsid protein, which contains the virus's genetic material, inhibiting viral replication. The team's laboratory experiments suggest that the virus's papain-like protease (PLpro) can remove the tag, recovering its ability to assemble new viruses and escape the innate immune response.

Discovery may lead to more effective drugs While the SARS and MERS viruses belong to the same virus family and also have an enzyme that can remove the ISG15 tag, their versions are less efficient and have a different primary target than that of SARS-CoV-2.

In a Kobe University news release today, senior author Ikuo Shoji, MD, PhD, said this finding may help guide the development of more effective and selective COVID-19 inhibitors that target SARS-CoV-2's nucleocapsid protein.

"We may be able to develop new antiviral drugs if we can inhibit the function of the viral enzyme that removes the ISG15 tag," he said. "Future therapeutic strategies may also include antiviral agents that directly target the nucleocapsid protein, or a combination of these two approaches."

Study Link: journals.asm.org/doi/10.1128/jvi.00855-24

Press Release: www.eurekalert.org/news-releases/1061645

[dyke-terra]

Yo, Mia Dearden fans. Found a one off panel appearance in Manhunter (2004).

IMAGE ID: A comic panel showing Mia as Speedy looking at a bottle of pills with Ollie looking on. A voice from a TV says: Many beneficial drugs already on the market-- such as some protease inhibitors used by HIV patients-- are ethically questionable due to Vesetech's involvement in their development." END ID.

[kunosoura]

Phone wallet keys… the fucking protease inhibitors

[elliepassmore]

It Was Vulgar and It Was Beautiful review

5/5 stars Recommended if you like: history, activism, LGBTQ+ history This book is probably one of the best nonfiction books I've read. The writing was engaging and I really connected with the people Lowery introduces in the pages. It's the kind of book that I was so invested in and whose content was so accessible that I wanted to just read it in one go. The book starts with an opening to the AIDS epidemic. We get to know some of the main people involved who were impacted by the crisis and how they reacted to it. I liked that we got this introduction instead of just jumping straight in to Gran Fury's work because it really explains the emotions of the time and how people felt compelled to act as well as just how devastating the AIDS epidemic was. While the main focus of the book is on Gran Fury and ACT UP, Lowery also follows the lives of the people involved in Gran Fury, some of the minutiae and politics of both, and how each can be placed in the context of the time. I actually think this information adds to the book and the story Lowery is telling, especially since it's information that might not be known to people coming into this book. It also helps to explain and provide context for some of the reactions of Gran Fury and ACT UP members (as well as other activists and organizations) later on in the book. The bulk of the book is spent describing the act Gran Fury created, the process of creating it, and the public's reaction to it. It was interesting to read about both the relatively unplanned, reactionary art that characterized the beginning of the movement and the more planned art that came later on. I definitely think this section is helpful for understanding how art and activism can stand together and how sometimes the message can get convoluted. Something I particularly liked about the book was that Lowery makes sure to point out that ACT UP was overwhelmingly white, overwhelmingly male, overwhelmingly cis. Despite the fact that Gran Fury recognized, and at times explicitly drew attention to, the fact that AIDS also impacted women, trans people, and people of color, the makeup of the groups weren't reflective of that fact. It was good to see that those things were acknowledge by Gran Fury, even if there was a gap in member representation. I also found it interesting how a number of Gran Fury members struggled with the so-called 'end of the AIDS epidemic' and recognized that protease inhibitors weren't the end for many, many people. Lowery also does not shy away from the truth and brutality of the AIDS epidemic and the sheer tragedy that came about as a result of the government's inaction. The number of people impacted by the crisis is incomprehensible, and Lowery makes sure that we readers understand that. It's definitely a heavy topic but I think it's important that it's included in the book. I can't really express how well I think this book does covering the topics it does and how it manages to be both thorough and engaging. I'll definitely be keeping my eye out for more nonfiction by Lowery.

[weakfleshwillingsoul]

2 separate protein preps failed within 2 days of each other. Spent a day harvesting and purifying A04 and pumping an insane amount of protease inhibitor into it just to have it die pathetically on the gel anyways, babysat it like a sick infant while it was on the centrifuge just to test the concentration and find there was no intact protein left in the solution. Same thing for the 292616, watched in horror as it ate shit on the chromatograph, ran a hail mary gel with the purified fractions regardless, every band was a handful of kilodaltons less than they should have been. No way of telling whether that was the chewed-up protein or some sort of uncanny contaminating imposter that eluted in its place. nearly 20 hours in the lab over the last couple days, exhausted to the point of surrealism ... had to discard everything. Must make new cultures on monday. Fifth A04 attempt, third 292616

[er-cryptid]

Aminocaproic Acid

Names -- Amicar -- Epsilon Aminocaproic Acid

Class -- hemostatic agent -- fibrinolysis inhibitor

Use -- management of acute, life-threatening hemorrhage due to systemic hyperfibrinolysis or urinary fibrinolysis -- prevention of recurrent subarachnoid hemorrhage -- prevention of bleeding following oral surgery for hemophiliacs -- management of severe hemorrhage caused by thrombolytic agents

Action -- inhibits activation of plasminogen -- plasminogen is a serum protease activated to form clots

[brookstonalmanac]

Events 12.6 (after 1940)

1941 – World War II: Camp X opens in Canada to begin training Allied secret agents for the war. 1956 – A violent water polo match between Hungary and the USSR takes place during the 1956 Summer Olympics in Melbourne, against the backdrop of the Hungarian Revolution of 1956. 1957 – Project Vanguard: A launchpad explosion of Vanguard TV3 thwarts the first United States attempt to launch a satellite into Earth orbit. 1967 – Adrian Kantrowitz performs the first human heart transplant in the United States. 1969 – Altamont Free Concert: At a free concert performed by the Rolling Stones, eighteen-year old Meredith Hunter is stabbed to death by Hells Angels security guards. 1971 – Pakistan severs diplomatic relations with India, initiating the Indo-Pakistani War of 1971. 1973 – The Twenty-fifth Amendment: The United States House of Representatives votes 387–35 to confirm Gerald Ford as Vice President of the United States. (On November 27, the Senate confirmed him 92–3.) 1975 – The Troubles: Fleeing from the police, a Provisional IRA unit takes a British couple hostage in their flat on Balcombe Street, London, beginning a six-day siege. 1977 – South Africa grants independence to Bophuthatswana, although it is not recognized by any other country. 1978 – Spain ratifies the Spanish Constitution of 1978 in a referendum. 1982 – The Troubles: The Irish National Liberation Army bombs a pub frequented by British soldiers in Ballykelly, Northern Ireland, killing eleven soldiers and six civilians. 1989 – The École Polytechnique massacre (or Montreal Massacre): Marc Lépine, an anti-feminist gunman, murders 14 young women at the École Polytechnique in Montreal. 1990 – A military jet of the Italian Air Force, abandoned by its pilot after an on-board fire, crashed into a high school near Bologna, Italy, killing 12 students and injuring 88 other people. 1991 – Yugoslav Wars: In Croatia, forces of the Serb-dominated Yugoslav People's Army (JNA) heaviest bombardment of Dubrovnik during a siege of seven months. 1992 – The Babri Masjid in Ayodhya, India, is demolished, leading to widespread riots causing the death of over 1,500 people. 1995 – The United States Food and Drug Administration approves Saquinavir, the first protease inhibitor to treat HIV/AIDS. Within 2 years of its approval, annual deaths from AIDS in the United States fall from over 50,000 to approximately 18,000. 1998 – in Venezuela, Hugo Chávez is victorious in presidential elections. 1999 – A&M Records, Inc. v. Napster, Inc.: The Recording Industry Association of America sues the peer-to-peer file-sharing service Napster, alleging copyright infringement. 2005 – An Iranian Air Force C-130 military transport aircraft crashes into a ten-floor apartment building in a residential area of Tehran, killing all 94 on board and 12 more on the ground. 2006 – NASA reveals photographs taken by Mars Global Surveyor suggesting the presence of liquid water on Mars. 2015 – Venezuelan parliamentary election: For the first time in 17 years, the United Socialist Party of Venezuela loses its majority in parliament. 2017 – Donald Trump's administration officially announces the recognition of Jerusalem as the capital of Israel.