#Medicines

[reasonsforhope]

"An international research team has found almost a million potential sources of antibiotics in the natural world.

Research published in the journal Cell by a team including Queensland University of Technology (QUT) computational biologist Associate Professor Luis Pedro Coelho has used machine learning to identify 863,498 promising antimicrobial peptides -- small molecules that can kill or inhibit the growth of infectious microbes.

The findings of the study come with a renewed global focus on combatting antimicrobial resistance (AMR) as humanity contends with the growing number of superbugs resistant to current drugs.

"There is an urgent need for new methods for antibiotic discovery," Professor Coelho, a researcher at the QUT Centre for Microbiome Research, said. The centre studies the structure and function of microbial communities from around the globe.

"It is one of the top public health threats, killing 1.27 million people each year." ...

"Using artificial intelligence to understand and harness the power of the global microbiome will hopefully drive innovative research for better public health outcomes," he said.

The team verified the machine predictions by testing 100 laboratory-made peptides against clinically significant pathogens. They found 79 disrupted bacterial membranes and 63 specifically targeted antibiotic-resistant bacteria such as Staphylococcus aureus and Escherichia coli.

"Moreover, some peptides helped to eliminate infections in mice; two in particular reduced bacteria by up to four orders of magnitude," Professor Coelho said.

In a preclinical model, tested on infected mice, treatment with these peptides produced results similar to the effects of polymyxin B -- a commercially available antibiotic which is used to treat meningitis, pneumonia, sepsis and urinary tract infections.

More than 60,000 metagenomes (a collection of genomes within a specific environment), which together contained the genetic makeup of over one million organisms, were analysed to get these results. They came from sources across the globe including marine and soil environments, and human and animal guts.

The resulting AMPSphere -- a comprehensive database comprising these novel peptides -- has been published as a publicly available, open-access resource for new antibiotic discovery.

[Note: !!! Love it. Open access research databases my beloved.]"

-via Science Daily, June 5, 2024

[wllya]

[spooniestrong]

10 Medications You Should Never Stop Abruptly - GoodRx

https://www.goodrx.com/drugs/side-effects/dangerous-medications-to-stop-abruptly

[angelnumber27]

Psychiatrists should directly at least even just briefly explain side effects instead of just asking symptoms and being like okay so you’re depressed? Let’s try *enter antidepressant* and boom you’re done. I know prescriptions almost always come with informational papers but I really truly doubt that most people read them. I honestly just feel it’s wrong and very careless to not disclose side effects to a patient and discuss those things with the patient before prescribing a medication.

[athena5898]

(Quds) The Euro-Med Human Rights Monitor has reported that over 70,000 Palestinians are trapped in the northern Gaza Strip, facing starvation and annihilation in the longest genocide campaign in modern history.

The Monitor further highlighted the catastrophic conditions faced by the residents of the North, with no access to food, water, medicines, or medical services, amid relentless Israeli attacks and massacres.

Catastrophic situation in Northern Gaza. Euro-Med Monitor Report +70,000 Palestinians are besieged in northern Gaza, facing starvation and annihilation in the longest genocide campaign in modern history. people in northern Gaza have been besieged for two months without access to food or medicine and amid relentless Israeli attacks Shocking statistics +150,000 Palestinians have been forcibly displaced since the start of Isreal's invasion on October 5

The besieged people are facing a real famine, as all types of food and clean water have run out, while Israeli bombings and military invasions of shelters and homes continue. Hundreds of civilians remain trapped under the rubble caused by Israeli airstrikes unable to be rescued as Israel has blocked civil defense teams from operating for over 41 days. "The international community's disregard for what is happening in northern Gaza represents an indelible stain on its conscience as it continues to exclude Palestinians from the protection of international law and its enforcement mechanisms due to political biases and international pressure." Euro-med Monitor

[whitelotusherald]

Just learned during work that Faramir and Boromir had a third brother who probably died of diabetes; let me introduce you...

[achromaticsideofme]

[mockva]

Chinese medicine

[poligraf]

« Medicine » by Gustav Klimt

[hallison-bre]

Rob Taxpayer performes Medicines at the Jurassic Park House in Portland, Oregon. 10/20/2011

Video credits to Virginia Holder on YouTube

[soniez]

The Evolution of Thyroid medicines From Early Treatments to Modern Solutions

The thyroid gland plays a vital role in regulating the body’s metabolism, growth, and development.  When the thyroid malfunctions—whether through overactivity (hyperthyroidism) or underactivity (hypothyroidism)—the entire body can feel its effects.  Over the years, thyroid conditions have become more widely recognized, leading to the evolution of effective medications that help manage these disorders.  The development of thyroid medicines has come a long way, transitioning from early rudimentary treatments to modern pharmaceutical innovations that offer patients a higher quality of life.

In this blog, we will explore the history and evolution of thyroid drugs, highlighting how thyroid medicines manufacturers in India and thyroid medicines exporters play a critical role in this process.  Additionally, we will discuss the increasing global demand for thyroid drugs, especially in regions like the Philippines, where thyroid medicines suppliers are crucial in ensuring access to life-saving medications.

The Early Days of Thyroid Treatments

Before modern thyroid drugs were developed, ancient civilizations used various natural remedies to manage symptoms of thyroid disorders.  Historical texts from Egypt, Greece, and China mention goiter, a visible swelling of the thyroid gland, which was often linked to iodine deficiency.  In these ancient times, treatments were rudimentary and primarily focused on addressing visible symptoms like goiter.

In the 19th century, scientific advancements began to shape the course of medical treatments.  One of the first breakthroughs in thyroid treatment came in 1891 when George Murray successfully treated hypothyroidism with thyroid extract derived from sheep.  This was the first instance of hormone replacement therapy and marked the beginning of the pharmaceutical management of thyroid disorders.

The Discovery of Iodine and Its Role in Thyroid Health

In the early 20th century, scientists discovered the importance of iodine in thyroid health.  Iodine is a key component in the production of thyroid hormones—T3 (triiodothyronine) and T4 (thyroxine).  It was found that iodine deficiency was one of the main causes of goiter and hypothyroidism.  This discovery led to the development of iodized salt as a preventive measure against iodine deficiency, significantly reducing the incidence of goiter worldwide.

However, while iodized salt helped prevent thyroid disorders caused by iodine deficiency, it did not address all thyroid conditions.  This led to the continued development of thyroid hormone replacement medicines for those with other forms of thyroid dysfunction.

The Emergence of Synthetic Thyroid medicines

In the mid-20th century, researchers made significant strides in developing synthetic thyroid hormones.  The introduction of synthetic levothyroxine (T4) in the 1950s revolutionized the treatment of hypothyroidism.  Levothyroxine, which is identical to the naturally occurring hormone produced by the thyroid gland, replaced the crude thyroid extracts used in earlier treatments.  Its standardized dosage and predictable absorption made it the gold standard for treating hypothyroidism.

Levothyroxine remains one of the most prescribed thyroid drugs globally, helping millions of patients manage their condition effectively.  Today, it is produced by leading thyroid medicines manufacturers in India and other countries, ensuring consistent quality and supply to meet global demand.

In addition to levothyroxine, synthetic T3 drugs, such as liothyronine, were developed to treat hypothyroidism.  While T3 medicines are less commonly prescribed than T4 medicines, they offer an alternative for patients who do not respond well to T4 therapy.

The Modern Approach to Thyroid Treatment

With the advancement of medical research and technology, the approach to thyroid treatment has become more sophisticated.  The focus is now on personalized medicine, where treatments are tailored to the individual’s specific thyroid hormone levels, symptoms, and overall health.

Thyroid hormone replacement therapy remains the cornerstone of treatment for hypothyroidism, but doctors now have a better understanding of the nuances in dosing and management.  For example, some patients benefit from a combination of T4 and T3 therapies, while others may require adjustments based on factors like age, weight, and the presence of other medical conditions.

The rise of thyroid medicines manufacturers in India has been instrumental in meeting the growing demand for thyroid medications.  Indian manufacturers are known for producing high-quality, cost-effective thyroid drugs, making these treatments accessible to patients worldwide.  In particular, Indian pharmaceutical companies have made significant contributions as thyroid medicines exporters, ensuring that countries with limited pharmaceutical production capabilities have access to life-saving medications.

Global Demand for Thyroid Drugs

Thyroid disorders are common worldwide, affecting millions of people.  Hypothyroidism, in particular, is a widespread condition that requires ongoing treatment with thyroid hormone replacement drugs.  As awareness of thyroid health increases, so does the demand for effective medications.

India has emerged as a key player in the global pharmaceutical market, with many thyroid drugs manufacturers in India producing a wide range of thyroid medications.  These manufacturers are able to meet both domestic and international demand by adhering to strict quality control measures and complying with global regulatory standards.

Indian companies are also recognized as leading thyroid drugs exporters, supplying medications to countries across Asia, Africa, Europe, and North America.  For example, in the Philippines, thyroid disorders are a significant public health issue.  Thyroid medicines suppliers in the Philippines rely on Indian manufacturers to provide a consistent supply of high-quality thyroid medications to meet the needs of their population.

The Role of Thyroid Drugs Suppliers in the Philippines

In countries like the Philippines, access to reliable thyroid medications is crucial for managing the high prevalence of thyroid disorders.  The Philippines faces unique challenges in terms of healthcare access, particularly in rural areas where medical resources may be limited.  As a result, thyroid medicines suppliers in the Philippines play an essential role in ensuring that patients have access to the medications they need.

By partnering with Indian thyroid drugs exporters, suppliers in the Philippines can provide patients with affordable and effective thyroid treatments.  This collaboration helps address the healthcare needs of a growing population and ensures that patients receive timely and consistent care.

The Future of Thyroid Drugs

As research into thyroid disorders continues to evolve, so too does the development of new and improved thyroid drugs.  Scientists are exploring new ways to optimize hormone replacement therapy, including the development of long-acting thyroid drugs that could reduce the need for daily dosing.  Additionally, advancements in biotechnology may lead to the creation of more personalized treatments based on genetic and molecular profiling.

Another area of focus is improving the delivery of thyroid drugs.  While oral tablets are the standard form of treatment today, researchers are investigating alternative delivery methods, such as transdermal patches and injectable formulations, which may offer more convenient options for patients.

As the pharmaceutical industry continues to innovate, thyroid medicines manufacturers in India are expected to remain at the forefront of these developments, producing the next generation of thyroid treatments.  With a strong presence as both manufacturers and exporters, Indian companies will continue to play a critical role in meeting the global demand for thyroid drugs.

Conclusion

The evolution of thyroid medicines from early treatments to modern solutions is a testament to the advancements in medical science and pharmaceutical manufacturing.  Today, patients with thyroid disorders have access to safe, effective, and affordable treatments that allow them to lead healthy, normal lives.

India’s pharmaceutical industry, particularly thyroid medicines manufacturers and thyroid medicines exporters, has played a key role in ensuring that thyroid medications are available to patients worldwide.  In regions like the Philippines, thyroid medicines suppliers are essential in meeting the needs of those affected by thyroid disorders, helping them access the treatments they require.

As we look to the future, continued innovation and collaboration within the pharmaceutical industry will further enhance the quality and accessibility of thyroid medicines, ensuring that patients everywhere receive the best possible care.

[sirswooshnoodles]

Me when the medicine that listed bad aftertaste in its possible side effects has a bad aftertaste:

[thoughtsonhurtandcomfort]

poppet

Author’s Notes: based on this post

poppet [pop-it] noun: A doll (such as a voodoo doll) made in witchcraft to represent a person, used in casting spells on that person.

                - also a British term of endearment or diminutive, much                                      like the words "dear" or "sweetie."

Content Warnings: tiny whump, faerie whump, magical whump, captivity, manhandling, torture, stomach/abdominal whump, blows to the stomach, pain, bruising, stomach ache, nausea, dizziness, illness, exhaustion, internal bleeding, medicine, painful caretaking

----

-day 1-

"He always...commented on my stomach. It wasn't flat enough or whatever."

“I’m so sorry, dear. We could starve him if you like? Or give him nausea?”

“I actually thought...something more external. Punch him in the stomach or - or something.”

The client sits sheepishly on one side of the desk. At the other sits Jade, a witch who has made a living by fulfilling the vengeful wishes of others.

Surrounding Jade on all sides are tables and shelves with an array of items: plants, herbs, spices, jars of liquid, stones, bowls and jars, fabric and string, tools and utensils of all sorts, dozens of books.

And a row of metal birdcages.

Only one is occupied - that is, until the witch plucks Shae from it and lays him out on his back on the surface of the desk. She waves a hand over him and whispers a spell. A tingling sensation fills him, like static in his veins.

“We can do something like that. But we can drag it out, if you like. Since you’ve booked the whole week.”

The client’s eyes glimmer. “Yeah? How?”

“Well, for example...pressure, applied over time.” She puts her thumb on Shae’s bare belly and presses. He jolts even though it doesn’t hurt - yet. “Just uncomfortable at first. Then we increase it - “ She presses and Shae’s breath catches. “And increase it...” Now it hurts. “...until it becomes unbearable.”

The client is nodding along. “And then?”

Jade smiles and removes her thumb. Shae breathes a sigh of relief too soon.

“Then we punch him.”

She demonstrates with several sharp flicks to Shae’s body that make him cry out.

By the third cry the client is already writing a check.

-

Just as promised, the torment is delivered slowly. That same day, the witch and her client simply sit across from each other, leaning over the faerie while Jade presses her thumb to his stomach just enough to make him squirm, releases him long enough for him to catch his breath, and then does it again.

It doesn’t take long for a mild bruise to form on the fragile faerie’s skin. When Jade presses on the print she left, Shae inhales so suddenly that it sends him into a coughing fit.

“I think that’s enough for today,” she decides, removing her hand quickly. “Don’t want it to be over too quickly, do we?”

While the witch sees her client out, Shae rolls onto his side with a groan and loosely wraps his arms around his aching stomach.

-

-day 2-

The next day the client doesn’t come in; Shae is foolish enough to believe he is safe. With a sigh he turns his face away from the light of morning and brushes his fingers over the painful thumbprint. I don’t think I could take anymore...

So it is a jarring, unpleasant surprise when Jade scoops him up. Groggy and stiff, he grumbles out quiet protests as he’s set once again on the desktop. He opens his eyes and looks around for the client.

“I bet you thought you got out of this,” she says with a smile. She has a calm, confident aura about her that would be a comfort if it didn’t hide a cruel streak.

“Wait, not - not again?” he rasps, still struggling to wake.

“No not again.”

He closes his eyes with a sigh of relief. Maybe she’s going to make it better.

“Something else today.”

“H-huh - “

She uncurls his body and pulls his arms away from where they try to shield his injury. She presses them out to his sides with her thumb and pinky, leaving him flat on his back and helpless.

With her other hand she reaches for something beside her - a one pound hand weight. Almost nothing for a human to hold, but the sight of it it sends a chill through the faerie. He knows exactly what that’s for.

“If you don’t move your arms they’ll be trapped,” she warns.

Shae moves them just in the nick of time, saving them but leaving his poor stomach defenseless as she settles handle of the weight across his body. The sudden pressure knocks the air from him. Shae hyperventilates - a big mistake.

“A-AH!”

His movements pull at his bruised skin, now pressed beneath the unyielding weight, indented by the curve of the handle. It hurts, which makes it hard to breathe, which makes it hard to stay still, which makes it hurt and hurt. The faerie pushes uselessly against the object with his little hands; of course, it doesn’t budge.

After a while he is too exhausted to panic anymore. Shae lies there panting with his arms sprawled out. His head droops to one side and he opens his eyes.

Only then, peering through his mop of hair, does he notice that the witch is gone. Instead of her face watching him closely there is a camera set up on top of a stack of books with a red light on.

Shae stares miserably into its dark eye and somehow knows the client is looking back.

Late that evening he weight is finally removed. The unconscious faerie lets out a sigh but doesn’t wake. The witch returns him to his cage, where he spends the night in a fitful sleep.

-

-day 3-

“She liked that one,” is how Jade greets him.

Shae has dragged himself to the back corner of the cage. He is sitting slumped back against one of the bars, staring down at the damage he has sustained - a new band of discolored bruising across his abdomen, slightly darker at the center where it has layered atop the thumbprint bruise. Whimpering, he hovers a hand over the inflamed skin, wanting soothe it, to give himself the comfort no one else will. He can’t bring himself to touch it for fear of worse pain.

Jade has no such qualms. She reaches in and lifts him with a hand around his torso, then lays him on his back on the desk. The camera is on.

The witch examines him carefully, clinically. She takes his pulse and his temperature, gives him droplets of water and juice. Shae gasps and claws at the desk when she rubs a minty-smelling ointment onto the tender bruising.

“We should take it easy today,” she tells the client over the phone. “Or this little guy isn’t going to make it until Friday...yeah, I know, but trust me, it will be worth it...yes, you can see closer.”

Jade holds Shae up, turning him this way and that. When the client is satisfied, they begin a short ‘session’, as the witch calls them. Shae lies there unrestrained but powerless nonetheless while, much like on the first day, Jade presses on various parts of his stomach and he cries and pleads.

-

-day 4-

The client is back. She watches while, at her request, Shae is forced to remain standing. His stomach muscles twinge. His legs wobble. He holds his sore belly and breathes through waves of nausea.

Occasionally he’ll open his teary eyes and peer up at the client, hoping she’ll decide to show mercy. But she is focused, watching him closely, waiting.

Shae holds out longer than the witch or her client expected, but there is only so much one little body can take. He collapses onto the desk.

At the same moment, all the way across town, the client’s ex collapses at work and is rushed to the emergency room.

-

-day 5-

“Last day. Any special requests?”

“What we discussed is perfect.” The client chews on her lip before adding, “I want him to feel like he’s dying, but not actually die.”

“Don’t worry, I’ll be careful. I’ve been doing this for ten years and I have never killed a target.”

The same cannot be said for the faeries who have stood in for her targets. Most she heals and keeps to reuse session after session. However, a few died moments after the spell was lifted, before she had the chance.

Jade retrieves the faerie and lays him out on the desk.

Shae is beyond exhausted from restless nights spent searching for a comfortable position - an impossible task for a badly bruised body lying on the floor of a metal cage. 

His arms remain curled protectively over his stomach but the witch easily moves them out of the way so the client can see the damage that has built over the week.

“There are no breaks, no organ damage,” she assures the client. “Only severe bruising and maybe a fractured rib.”

Reassured, the client writes out a final check.

Shae remains flat on his back with his arms out and his eyes closed. He almost manages to drift off when a shadow falls over him, blocking out the lamp. Fear forces his eyes to open.

The witch’s hand hovers about a foot above him. She is looking right at him and speaking quickly, words Shae doesn’t understand but he tenses with fear all the same.

And he is right to.

No sooner has the last word left Jade’s lips than some invisible force slams into Shae’s tender stomach. It knocks the breath from him.

She speaks the same final word again, and a third time, and a fourth, and each time it is followed by a swift blow. His body spasms with each impact.

When the blows cease Shae is left coughing and wheezing, sparks in his vision. The longer he lies there the worse he feels. This time it doesn’t just hurt; this time something is very wrong.

He feels lightheaded, clammy, nauseous. His little heart is pounding fast. He can hardly breathe. When he holds a trembling hand to his stomach the touch is so excruciating that he almost blacks out.

He feels like he’s dying - but he doesn’t die.

Shae doesn’t remember turning onto his side but somehow finds himself doubled over and coughing until he tastes blood. He’s so sick, so delirious with pain that he doesn’t notice the final conversation between witch and client, nor the satisfied look the client gives him before she leaves.

The next thing he knows he’s being held in a cool hand. A steady voice whispers to him and in an instant the tingling feeling of the spell has disappeared, breaking the faerie’s connection to the human victim. If only the pain would disappear along with it.

Jade lifts a dropper to Shae’s lips and gives him something something bitter and syrupy. He swallows it, coughs raggedly, grimaces at the taste.

“You’ll be good as new by morning,” she promises.

The witch dotes on the faerie methodically, efficiently, but not gently or with care. She rubs more of the mint-smelling ointment onto him, gives him water, even dresses him in new clothes.

She is about to put him back into the cage when, Shae utters a breathless little, “wait.”

To his surprise she stops and looks at him. He is draped over the curve of her thumb and forefinger, half-conscious and limp in her loose grip.

“What is it?”

“Could - could I - “

He has to stop to cough. The witch waits, curious, while he catches his breath.

“C-could I - have a - a blanket - a pillow - anything. Please?” Shae practically sobs the words; he can’t bear another night seeking rest on cold metal.

“Yes, alright. I think you’ve earned it.”

Maybe he shouldn’t feel grateful given what he’s been through, but when a few moments later Shae is settled onto a washcloth, and a second just like it is draped over him, it reduces him to tears. He sinks into the soft, clean cotton; he sighs as the medicine starts to kick in, just a little, dulling the edge of his pain.

He sleeps well for the first time all week. In the morning, just like she promised, he is healed - as though none of it ever happened.

[earlgreydarkchocolate]

The world is a curse, it'll kill if you let it

I know they got pills that can help you forget it

They bottle it, call it medicine

But I don't need drugs

- High enough, K Flay

[legolonia]

Norm Alguy.

I tell you Norm, everyone our age needs a walk in medicine cabinet.

#lego #mini figure #toys #toy-photography #legophotography #greyscale #blackandwhite #fun #livingwithfibromyalgia #chronicfatigue #normalguy #legolonia #awesome #minifig #playwell #staywell #justanormalguylivinganormallife #olympus #desktopphotography #lifeisgood #medicines #medicinecabinet #walkin #oldmates