#Katalin Karikó

[mcb3k]

Nobel Prize recognizes scientists who laid groundwork for COVID-19 vaccines : Shots - Health News https://www.npr.org/1202941256

The 2023 Nobel Prize for Physiology or Medicine has been awarded to Hungarian-born Katalin Karikó and American Drew Weissman for work that enabled the development mRNA COVID-19 vaccines. Their work, undertaken at the University of Pennsylvania, made it possible to develop vaccines based on genetic material called messenger RNA. The scientists discovered that changing a chemical building block of mRNA – substituting pseudouridine for uridine — eliminated an inflammatory side effect that was a barrier to development of this new kind of vaccine. They published their work 15 years before the COVID pandemic.

[chrisquartet]

I forgot to post this when I woke up.

[hicapacity]

Mindig mondtam, hogy fölösleges tanulni. 🤩

/Kovács Gergely - MKKP - Magyar Kétfarkú Kutyapárt/

[nando161mando]

"Rosalind Franklin discovered the DNA double helix in 1953, but she never won a Nobel Prize due to sexism.

Years later, Katalin Karikó was kicked out and forced to retire from academia.

Despite this, 70 years after Franklin's discovery, Karikó was awarded the Nobel Prize for developing life-saving #COVID vaccines from another nucleic acid, mRNA."

https://www.reddit.com/r/HermanCainAward/

[gpstudios]

Celebrating World RNA Day: Exploring the Wonders of Ribonucleic Acid 🌍🔬

Happy World RNA Day! 🌍🔬 Celebrate the incredible world of RNA and its vital role in biology and medicine. Learn about RNA, support research, and promote STEM education. #WorldRNADay #RNAResearch

Introduction Happy World RNA Day! 🌍🔬 Celebrated annually on August 1st, World RNA Day is dedicated to recognizing and appreciating the crucial role of RNA (ribonucleic acid) in biology and medicine. RNA is essential for numerous biological processes, including protein synthesis and gene regulation. Today, we celebrate the scientific discoveries and innovations surrounding RNA and its profound…

[younes-ben-amara]

البطلُ مهدي مالك (مغربي 41 سنة) فاقد للحركة أَلَّفَ كتابين؛ وأنت ذكِّرني مرة أخرى ما عُذرك لئلا تكتب؟

ما هذه المجموعة من المختارات تسألني؟ إنّها عددٌ من أعداد نشرة “صيد الشابكة” اِعرف أكثر عن النشرة هنا: ما هي نشرة “صيد الشابكة” ما مصادرها، وما غرضها؛ وما معنى الشابكة أصلًا؟! 🎣🌐 🎣🌐 صيد الشابكة العدد #80 🎣🌐 صيد الشابكة العدد #80🔌🧠 جدير بالاطلاع🍲 العِلم (قصة حائزة على نوبل 2023) لا يطعمك لا في بلاد عربستان ولا في بلاد العم سام في حال لم تُسوِّق لنفسك🥣 الآن هل العلم بيوكّل عيش في مكان آخر؟ بلاد…

[i-am-the-oyster]

How am I just now hearing that Katalin Karikó won a Nobel prize for her work on mRNA vaccines?

[higherentity]

[nicolae]

Premiul Nobel pentru Fiziologie sau Medicină, 2023: Katalin Karikó și Drew Weissman, pentru contribuțiile la vaccinurile ARNm pentru COVID-19

Credit: Shuqin Xu, Kunpeng Yang, Rose Li și Lu Zhang/Wikimedia Commons, licență CC BY 4.0 (Transcripție in vitro ARNm, activarea imunității înnăscute și adaptive. ) Adunarea Nobel de la Institutul Karolinska a decis astăzi să acorde Premiul Nobel pentru Fiziologie sau Medicină în 2023 împreună lui Katalin Karikó și Drew Weissman, pentru descoperirile lor referitoare la modificările bazei…

[jinxxpal]

Ever since more than a decade ago clowns and criminals took over my homeland, it's really hard to be proud of Hungary. Even in such rare occasions all I see is a brilliant scientist who had to go to another country to achieve true greatness. I fear for the future of the land, our leaders have failed us, education and healthcare systems and crumbling, inflation is the double of the European average, and the brainwashed population is only worried about the LGBTQ community grooming kids. Fuck my life.

[quotesfrommyreading]

In April 2020, as COVID was circumnavigating the globe and demolishing normalcy everywhere, The New York Times published an article titled “How Long Will a Vaccine Really Take?” Although Trump-administration officials aimed to unveil a COVID vaccine within 18 months—that is, by the fall of 2021—the journalist Stuart Thompson reminded readers that the shortest time in history for developing a new vaccine was four years. “The grim truth,” he wrote, “is that a vaccine probably won’t arrive any time soon.” But then it did. The first mRNA vaccines were administered before the end of 2020.

The COVID vaccines underline a second lesson from the smallpox story. Some technology myths make it seem like progress is exclusively the work of geniuses, untouched by the grubby hands of politicians and bureaucrats. But a rogue cadre of inventors didn’t eradicate smallpox. States did. Agencies did. Progress is often political, because the policy decisions of states and international organizations frequently build the bridges between discovery and deployment.

The story of the mRNA vaccines can be traced back to the ’90s, when the Hungarian-born scientist Katalin Karikó began her research on the pharmaceutical potential of mRNA, a small but mighty molecule that tells our cells what proteins to make. Her work, along with that of her fellow University of Pennsylvania researcher Drew Weissman, gradually raised our mastery of mRNA to the point where it could be deployed for a vaccine. In early 2020, within 48 hours of receiving the genetic sequencing of the coronavirus, Moderna had prepared its COVID-vaccine recipe, and BioNTech, a German firm that later partnered with Pfizer, had designed its own vaccine candidate.

These technological breakthroughs, building on decades of basic research, were themselves miracles. But alone, they weren’t enough. The U.S. also needed a policy miracle—a feat of bureaucratic ingenuity that would make, distribute, and administer novel vaccines with record-breaking efficiency. We got just that with Operation Warp Speed, which belongs with the Apollo program and the Manhattan Project as one of the most important technology programs in the history of modern federal policy. It likely saved hundreds of thousands, if not millions, of lives.

From the beginning, Warp Speed’s job seemed nearly impossible. To create the fastest vaccine program ever, officials had to essentially map out the entire journey of a new therapy—from research and clinical trials to regulatory approval and distribution—and turn this obstacle course into something like a glide path. They invested in both traditional and mRNA vaccine approaches, paid up front for clinical trials, and placed billions of dollars in advance orders to urge pharmaceutical companies to move as fast as possible. When Moderna needed more manufacturing facilities, Warp Speed provided funding for additional factory space. When the government identified a shortage of the special material that mRNA vaccines require for ultracold transport, Warp Speed granted $347 million to SiO2 and Corning, two manufacturers of glass vials. And because standard vaccine approval from the FDA can take years, the program’s leaders allowed vaccine makers to proceed with emergency use authorizations to speed up the review process.

“The single most important thing that Operation Warp Speed did was to provide a whole-of-government urgency” to the goal of rapid deployment, Caleb Watney, a co-founder of the Institute for Progress, told me. “Getting everything right meant you needed to make a million correct decisions in the right order.” If the government had bet only on traditional vaccine technology, we would have had no mRNA therapies. If the government hadn’t done extensive supply-chain mapping in the summer of 2020, the initial vaccine rollout might have taken months rather than weeks. And if the government hadn’t bought out vaccines from the pharmaceutical companies, they wouldn’t have been free to consumers. But because Operation Warp Speed did all of this, the vaccines were expeditiously approved, manufactured, and distributed at no cost to the public.

Warp Speed was a special case, essentially a wartime policy applied to a health crisis. Few people would recommend such an aggressive approach for developing ordinary consumer technology. And the government is certainly capable of making bad choices as to exactly what technology to develop, and how. But while too much government action on this front can waste money, too little can waste time and even lives, stymieing possible breakthroughs. Warp Speed showed that smart government action can accelerate discovery and deployment. Just as significant, it showed that the kinds of bets the government can place, such as FDA reforms, don’t necessarily involve spending any money at all.

  —  Why the Age of American Progress Ended

[bookwormstarwarsfan]

OMG!

Another!

Krausz Ferenc won the Nobel-prize in physics with two other scientist!

Karikó Katalin won a Nobel-prize!

She is the 15th Hungarian Nobel-prize winner (there were two other of Hungarian origin) and more importantly the first woman!

Any time the topic of the unusually high number of Hungarian Nobel-prize winners comes up, we can't ignore the sad fact that only two of them won their prize while living in Hungary and doing their activity in Hungary, but even them had to disappoint in the country, the others had to emigrate or their parents already left Hungary. It's not diffenrent in Karikó's case either.

But still, rather than being sad over this, I'm cheering for her because she slayed as a scientist, as a woman and a little bit as a Hungarian, and I'm remembering the time when she visited my school after the success of the vaccine with a cheerful attitude and a freaking backpack!

(I have zero photographic skills.)

[diogenesz2020portugal]

A Svéd Királyi Tudományos Akadémia döntése értelmében a 2023. évi fiziológiai és orvostudományi Nobel-díjat Karikó Katalinnak és Drew Weissmannak ítélték oda a módosított nukleozidokkal kapcsolatos felfedezéseikért, amelyek lehetővé tették a Covid-19 elleni hatékony mRNS-vakcinák kifejlesztését.

[telavivdelhi2]

Telex: Volt miépesekkel menzateáztam órákon át, közben horthyztak, csurkáztak és zsidóztak körülöttem

Bár van, aki nem ért egyet vele, a legnagyobb ellenszenvet mégsem ez a téma kapja, hanem az egykori miépes képviselő, Mestyanek Ödön, aki mintha szintén nem tudná, milyen rendezvényen van. Egyszer csak arról kezd el beszélni, hogy milyen jó, hogy ezt a vakcinát a Covid ellen feltalálták, “egy zseniális dolgot talált ki Karikó Katalin”. Erre a találkozó résztvevői egy emberként zúdulnak fel, fújolják ki. “Rengeteg ember hal meg naponta az oltás miatt. Karikó Magyarország szégyene. Le kellene tagadnunk Karikó Katalint. A pokolba vele” – érkeznek sorban a bekiabálások.

Fasizmus: a pszichopaták és az ostobák találkozása

[hicapacity]

A KiraKós KövetKező darabja 😎👌