#Jesse Kirsch

[designmiss]

Gubble Bum https://www.design-miss.com/gubble-bum/ “Gubble Bum” disegnato da Jesse Kirsch, è un packaging per le confezioni di gomma da masticare. Sotto la bizzarra e colorata parte esterna si trova una sorpresa inaspettata: la rimozione […]

[chriscdcase95]

Loves Sacrifices update: "A Sight For Sore Eyes" three parter

Chapters 16 to 18 are up, and I've been waiting for over a year to post this.

This is a three part chapter, and I wanted to wait until all three were up before making this post. I had to split because all three parts put together is nearly five hours of reading. Almost as long as all three Pitch Perfect movies back to back.

I kept saying I wanted to finally get the baby shower done for over two years, and now it's finally finished. What else is that this chapter is meant to wrap up the Bailey Downs arc…which is why it took a while for me to get too.

This is also meant to be a siege chapter, much like I did with Unlife is Strange. Because of how long it took me to get these out, I'm also taking a little break from Love's Sacrifices, and going to be focusing on finishing Mission to Silas, and getting back to writing Unlife.

And since this is meant to wrap up the Bailey Downs storyline, think of it like a "Mid Season" finale.

Which also leads me to this content warning.

Like I said, this is meant to be a battle chapter, and it's probably where the story gets to its darkest points. You may even forget this is a Pitch Perfect crossover.

These chapters include: Blood, light gore and mutilation. Vampire related violence. Werewolf related violence. Demon related violence, curtesy of Lamashtu. Nudity and mild sexuality. Torture. Shooting and gun violence. Children being threatened.

And of course, character death; these three chapters will see two named characters, who were introduced in the first few chapters, being killed off.

...or you could read the TV Tropes page and see who bites it in advance. But what's the fun in that ?

Anyways, links to all three parts down below.

Part one

Part two

Part three

[wearelondonhq]

do yall have a most wanted list? im trying to narrow down who im wanting to play... but wanted to see who is really wanted! (:

hello, lovely! we asked our members and some honourable mentions were: daryl dixon, rosita espinosa, rick, carl, michonne and judith grimes, lori grimes, abraham ford, king ezekiel, carol peletier, eugene, lucille smith (twd), sam wilson, peter quill, gamora, nebula, carol danvers, kamala khan, happy hogan, peter parker 3, norman osborn (marvel), selina kyle, rick flag, peacemaker, jim gordon, barbara kean (dc), katniss everdeen, finnick odair, gale hawthorne, primrose everdeen (thg), zepp hindle, alison gordon, addison corday, laura hunter, jeff denlon, dylan denlon (saw), mark kincaid, richie kirsch, ethan landry, jill roberts, roman bridger (scream), rhaena targaryen, harwin strong, laenor and laena velaryon (HOTD), audra denbrough, beverly marsh, anyone from IT, dulcinea del tobosco, jesse evans (billy the kid), resident evil peeps, any available X-men, any available gotham rogues, crassus snow (TBOSAS),anyone from ASOUE but especially sunny or klaus baudelaire, more characters from witcher, more from batman, more ouat characters (prince charming, snow white, rumplestiltskin and henry mills being very wanted), grover underwood (percy jackson) and more! loves, please feel free to add on to this with your mw!

[mediamonarchy]

https://mediamonarchy.com/wp-content/uploads/2024/05/20240508_MorningMonarchy.mp3 Download MP3 Deep pfarma pfakes, medium rare admissions and saccharine histories + this day in history w/super-sized mental hellpf and our song of the day by Jesse Daniel on your #MorningMonarchy for May 8, 2024. Notes/Links: Deepfake video falsely pitches dietary supplement “created with Pfizer” as diabetes remedy https://www.poynter.org/fact-checking/2024/deepfake-video-falsely-pitches-dietary-supplement-created-with-pfizer-as-diabetes-remedy/ Video: Breaking: Pfizer Halts Diabetes Pill Trial Due to Alarming Side Effects | Redacted w Clayton Morris (Jun. 28, 2023 // Audio) https://www.youtube.com/watch?v=8QzKKJ0h5Jo Pfizer to discontinue twice-daily weight loss pill due to high rates of adverse side effects (Dec. 1, 2023) https://www.cnbc.com/2023/12/01/pfizer-to-discontinue-twice-daily-version-of-weight-loss-pill.html Image: @Hybrid’s Cover Art – The Jigglenauts’ ‘Statistically Significant’ https://mediamonarchy.com/wp-content/uploads/2024/05/20240508_MorningMonarchy.jpg The craze for weight-loss drugs has led to slim supply and big earnings https://sherwood.news/snacks/business/the-craze-for-weight-loss-drugs-has-led-to-slim-supply-and-big-earnings/ Video: ELI LILLY COMMERCIAL 2024 | “SHAME” | OBESITY IS A MATTER OF HEALTH. SHAME HAS NO PLACE IN IT. (Audio) https://www.youtube.com/watch?v=P4J0EHCHYtw Lizzo’s fans criticize her for taking Ozempic to lose weight (Jan. 3, 2024) https://sandrarose.com/2024/01/lizzos-fans-criticize-her-for-taking-ozempic-to-lose-weight/ Lizzo Says She Is ‘The Beauty Standard’ As She Celebrates Her Body (Apr. 17, 2023) https://www.outlookindia.com/art-entertainment/lizzo-says-she-is-the-beauty-standard-as-she-celebrates-her-body-news-278973 NYT, believe it or not: Thousands Believe Covid Vaccines Harmed Them. Is Anyone Listening? http://archive.today/3MItE The CDC lied; people died; Steve Kirsch supplies some additional facts re: today’s Epoch Times article that revealed the CDC cover-up of COVID-19 vaccine caused deaths https://kirschsubstack.com/p/the-cdc-lied-people-died EXCLUSIVE: CDC Found Evidence COVID-19 Vaccines Caused Deaths; File presents evidence of a massive cover-up by CDC officials who found reasons to discard autopsies and death certificates that indicated COVID-19 vaccines were the cause of death. https://archive.ph/Qbu0S AstraZeneca cops to rare, deadly side effect of COVID jab as lawsuits mount https://nypost.com/2024/04/29/world-news/astrazeneca-cops-to-rare-deadly-side-effect-of-covid-jab-as-lawsuits-mount/ AstraZeneca admits in court that its ‘Covid vaccine can cause TTS side effects in rare cases’ https://archive.is/ZMy3S Video: Popular Covid jab reveals rare deadly side effect https://www.youtube.com/watch?v=bl-KjxNGs6A Video: AstraZeneca Admits Covid Vaccine Can Cause Side-Effects In Very Rare Cases | IN18V | CNBC TV18 (Audio) https://www.youtube.com/watch?v=NHMQ5jGHStM AstraZeneca withdrawing Covid vaccine worldwide; Company says decision is purely commercial as jab has been superseded by alternatives https://archive.is/BDgX8 November 2023: GP surgery blunder led to healthy 28-year-old being given fatal AstraZeneca Covid jab; Alex Reid suffered rare blood clot caused by vaccine after childhood records were used that mistakenly classified him as morbidly obese https://web.archive.org/web/20240430140823/https://www.telegraph.co.uk/news/2023/11/14/man-died-blunder-astrazeneca-covid-jab/ April 2024: Coroner issues warning after healthy man, 28, died of a blood clot when he was given AstraZeneca Covid jab early due to GP blunder which wrongly recorded him as being an obese child https://www.dailymail.co.uk/news/article-13366353/coroner-warning-healthy-man-died-blood-clot-astrazeneca-covid-jab.html Here We Go Again: Gretchen Whitmer admin issues emergency executive order over avian influenza https://www.themidwesterner.news/2024/05/here-we-go-again-gretchen-whitmer-admin-issues-emergency-executive-order-over-avian-influenza/ 5/6/24: CH...

[emma-cantmakeuphermind]

Who and What I Write For!!!

If a Fandom/Character is Bolded, that means requests for them are Open. If it is not bolded, they are closed. Thank you!

Movies

Harry Potter

Harry Potter

Ron Weasley

Hermione Granger

George Weasley

Fred Weasley

Cedric Diggory

Seamus Finnigan

Draco Malfoy

Oliver Wood

Remus Lupin (Marauders Era)

James Potter (Marauders Era)

Sirius Black (Marauders Era)

Regulus Black (Marauders Era)

Lily Evans (Marauders Era)

Marlene McKinnon (Marauders Era)

Mary MacDonald (Marauders Era)

Fear Street

Simon Kalivoda

Kate Schmidt

Tommy Slater

Nightwing Killer

Ziggy Berman

Nick Goode

Solomon Goode

Mad Thomas

IT

Richie Tozier (young and old)

Bill Denbrough (young and old)

Stanley Uris (young and old)

Ben Hanscom (young and old)

Eddie Kaspbrak (young)

Beverly Marsh (young)

Mike Hanlon (young)

Marvel

Peter Parker (MCU)

Peter Parker (TASM)

^ frat!peter… iykyk

Steve Rogers

Bucky Barnes

Wanda Maximoff

Natasha Romanoff

Sam Wilson

Bruce Banner

Tony Stark

Scott Lang

Scream

Sidney Prescott

Billy Loomis

Stu Macher

Randy Meeks

Dewey Riley

Tatum Riley

Derek Feldman

Mickey Altieri

Roman Bridger

Kirby Reed

Charlie Walker

Tara Carpenter

Wes Hicks

Chad Martin-Meeks

Mindy Martin-Meeks

Richie Kirsch

Amber Freeman

Anika Kayoko

Ethan Landry

Back to the Future

Marty McFly

George Mcfly

The Breakfast Club

Andrew Clark

Brian Johnson

John Bender

Claire Standish

Allison Reynolds

Stand By Me

Teddy Duchamp

Chris Chambers

Dead Poets Society

Neil Perry

Charlie Dalton

Todd Anderson

Knox Overstreet

Steven Meeks

Gerard Pitts

Richard Cameron

Chris Noel

Bill and Ted’s Excellent Adventure

Bill Preston Esquire

Ted Logan

Billy The Kid

The Hunger Games

Peeta Mellark

Finnick Odair

Johanna Mason

Cato

Marvel

TV Shows

The Walking Dead

Rick Grimes

Daryl Dixon

Carl Grimes

Glenn Rhee

Alden

Negan Smith

Rosita Espinosa

Tara Chambler

Stranger Things

Steve Harrington

Eddie Munson

Mike Wheeler

Dustin Henderson

Lucas Sinclair

Max Mayfield

Robin Buckley

Jonathan Byers

Billy Hargrove

Ginny and Georgia

Marcus Baker

Abby Littman

Hunter Chen

Shameless

Lip Gallagher

Carl Gallagher

Kevin

V

Svetlana

Jimmy

Video Games

Bully

Jimmy Hopkins

Gary Smith

Petey Kowalski

The Last of Us

Joel Miller

Ellie Williams

Abby Anderson

Jesse

Dina

Red Dead Redemption

Arthur Morgan

John Marston

Durch van der Linde (1899)

Jack Marston (1911 and 1914)

Sean Macguire

Karen Jones

Charles Smith

Javier Escuella

Detroit: Become Human

Connor

Markus

Simon/Daniel/PL600

Rupert/WB200

Life Is Strange

Chloe Price (specifically BTS)

Nathan Prescott

Warren Graham

Sean Diaz

Daniel Diaz (older obvi)

Steph Gingrich

Ryan Lucan

Hogwarts Legacy

Sebastian Sallow

Ominis Gaunt

Gareth Weasley

Leander Prewett

TellTale’s The Walking Dead

Kenny

Clementine

Luke

Javier

Gabe

Mitch

Louis

Marlon

James

Other

Miscellaneous 80s Characters

Edgar Frog

Allen Frog

Sam Emerson

Johnny Cade

Ponyboy Curtis

Sodapop Curtis

Dally Winston

Ferris Bueller

Egon Spengler

Peter Venkman

Alex P. Keaton

Miscellaneous Non-80s Characters

Harley Quinn

Peter Kavinsky

Donnie Darko

Detective David Loki

Homer Hickam

Beck Oliver

Jade West

Rodrick Heffley

[tragerflaws]

New pinned post, bc bestie reminded me I have a writing account. I'm also @wadeheberts & @mysterionhex

Hello! This is a request based fic account :D! While it won't be enforced super strictly, I would prefer this account be followed only by people over the age of 15 due to (NON SEXUAL) mature themes in my source materials :)

I'm Jesse, 17, he/she/it pronouns, and I write fanfiction for myself and others :).

Due to me being 17, and also not having an interest in it, and prioritizing my safety, I will not write anything sexually nsft. I also won't write anything that could be upsetting on a large scale, such as various forms of sexual trauma and other uncomfortable things. IF I write anything in which a character is a super gross kind of terrible person, please note that they're not to be supported in that aspect and not written in support of that aspect. (IE Richie Kirsch)

I'll accept any requests as long as they're sfw and have no sexual implications. I'll write platonic or romantic depending on if I like whatever you're requesting.

Here's fandoms I'll write for with characters I like writing for :D!

The SCREAM franchise. (I like writing the 1996 cast of characters the most and I'm most comfortable with them and Jill Roberts & Charlie Walker, but I'll attempt anyone)

BREAKING BAD. (I like writing for Jesse and his group of friends the most. I won't write for Better Call Saul because I've only watched the first season and don't plan on ever finishing it.)

The HALLOWEEN franchise. (I've only watched the original and the reboot series(2018, Kills, & Ends))

SONS OF ANARCHY (I like writing for Juice, Chibs, and Tig the most. I also have an OC I plan on writing about >:))

Z NATION (up until season 3. I like writing for 10k and Murphy the most, but I'm willing to write most characters :))

SUPERNATURAL (up until season 11 bc I don't like the rest of the seasons/haven't watched them in a long time. I like writing for the Winchesters, Castiel, and Charlie Bradbury the most. I won't write anything with John or Mary Winchester as the main charas bc I don't like writing them lmao)

I'm currently taking all requests! Unfortunately, I'm considering every request I've received thus far abandoned because I can't find any interest in them :(

[woodsborostabathon]

aka the user formerly known as ambersrequel (rip). ceci / 22 / she/her / lesbian / boricua but i get a lil yeehaw with it. i'm not quite as strict with my dni criteria as i am with my headcanons! basically just don't follow me if you're: an anti, under 18, or have a habit of bashing any of the media i'm into. i'm proship and don't play about my faves, so please don't get me started.

speaking of my faves, this is kinda-sorta an about, kinda-sorta a masterlist of them!

˗ˋˏ ♡ ˎˊ˗ 𝐁𝐎𝐎𝐊𝐒.

lolita. vc andrews' dollanganger & casteel family sagas. my best friend's exorcism. stephen king's work (mainly carrie & misery). the kingdom of little wounds. the miseducation of cameron post. the mortal instruments. twilight. the virgin suicides. richard siken's work. junji ito's work (mainly tomie, dissolving classroom, & uzumaki). dark water. toradora. blood on the tracks.

˗ˋˏ ♡ ˎˊ˗ 𝐌𝐎𝐕𝐈𝐄𝐒 (𝐇𝐎𝐑𝐑𝐎𝐑).

scream franchise (esp. films 4-6). saw franchise. the ring. final destination franchise. nightmare on elm street (1984. dream warriors. & 2010). dark water (both vers.). the exorcist. tragedy girls. marrowbone. get out. us. barbarian. abigail. ready or not. candyman (both vers.). mama. orphan. fatal attraction. it (1990). house of wax. the witch. silent night deadly night. village of the damned (1995). bloody birthday. the bad seed (1956). the craft. forget me not. my bloody valentine (2009). sleepaway camp. jennifer's body. silent hill. hereditary. white: curse of the melody. cinderella (2006). sinister (1 & 2). carrie (1976 & 2013). sorority row. ouija: origin of evil. lisa frankenstein . . . full list on my letterboxd bc otherwise, i'd keep going forever.

˗ˋˏ ♡ ˎˊ˗ 𝐌𝐎𝐕𝐈𝐄𝐒 (𝐍𝐎𝐍-𝐇𝐎𝐑𝐑𝐎𝐑).

lolita (both vers.). the virgin suicides. flowers in the attic (both vers.). but i'm a cheerleader. welcome to the dollhouse. bottoms. the addams family (1991 & values). the hunger games. twilight saga. suicide squad (2016 & 2021). thirteen. heavenly creatures. heathers. gone girl. the room.

˗ˋˏ ♡ ˎˊ˗ 𝐓𝐕 𝐒𝐇𝐎𝐖𝐒.

euphoria. you. interview with the vampire. house of the dragon. yellowjackets. supernatural. the summer i turned pretty. law & order: special victims unit. cruel summer. american horror story. that 70's show. criminal minds. ginny & georgia. shadowhunters. death note. mirai nikki. black mirror. love, victor. big love. deadly women.

˗ˋˏ ♡ ˎˊ˗ ��𝐀𝐌𝐄𝐒.

the sims (mainly 2 & 4). crusader kings iii. phasmophobia. dead by daylight. roblox. content warning. fire emblem (awakening & fates).

˗ˋˏ ♡ ˎˊ˗ 𝐌𝐔𝐒𝐈𝐂.

xana. ice nine kills. lana del rey. ethel cain. glass animals. flower face. marina. pom pom squad. chappell roan. melanie martinez. the technicolors. idkhow. ayesha e. waterparks. hey violet. mother mother. taylor swift. sza. panic! at the disco. my chemical romance. the weeknd. olivia rodrigo. young miko.

˗ˋˏ ♡ ˎˊ˗ 𝐅𝐀𝐕𝐄 𝐂𝐇𝐀𝐑𝐀𝐂𝐓𝐄𝐑𝐒.

amber freeman. charlie walker. the kirsch siblings. sidney prescott. dewey riley. kirby reed. tara carpenter. chad meeks-martin. liv mckenzie. vince schneider. anika kayoko. amanda young. john kramer. carrie white. nancy thompson. quentin smith. jesse braun. louis & claudia de point du lac. lestat de lioncourt. shauna shipman. jackie taylor. dahlia williams. chris & regan macneil. samara morgan. angela baker. alessa gillespie. wendy christensen. esther coleman. mara chaffee. rhoda penmark. joe goldberg. love quinn. delilah & ellie alves. yuno gasai. misa amane. debbie brody. jennifer check. needy lesnicki. billy chapman. pearl. tomie kawakami. grace le domas. nan (ahs). alicent hightower. rhaenyra targaryen. helaena targaryen. jace velaryon. dolores haze. nate jacobs. maddy perez. cassie & lexi howard. fezco. gomez & morticia addams. wednesday addams. olivia benson. jeanette turner. jackie burkhart. steven hyde. the dollanganger siblings. heaven & tom casteel. isabelle & alec lightwood. magnus bane. simon lewis. carlisle & alice cullen. rosalie hale. cecilia lisbon. dawn wiener. cameron post. abby rivers. gretchen lang. harley quinn.

˗ˋˏ ♡ ˎˊ˗ 𝐒𝐏𝐄𝐂𝐈𝐀𝐋 & 𝐎𝐓𝐇𝐄𝐑 𝐈𝐍𝐓𝐄𝐑𝐄𝐒𝐓𝐒.

ocs. writing. the flds. some other cults + religious fundamentalism. psychology. video editing. video essays. book collecting (specifically 1st edition vca). lovecore + 'coquette' aesthetics. dogs. being silly & perhaps even goofy.

˗ˋˏ ♡ ˎˊ˗ 𝐌𝐘 𝐎𝐓𝐇𝐄𝐑 𝐁𝐋𝐎𝐆𝐒.

slashersimmer (simblr), slashersweethearts (horror fandom ocs).

[slashersweethearts]

♡ 𝐎𝐂 𝐃𝐈𝐑𝐄𝐂𝐓𝐎𝐑𝐘. ♡

🔪 ┆ 𝗦𝗖𝗥𝗘𝗔𝗠 (𝟭𝟵𝟵𝟲).

… ♡⠀ALICIA 'BLAKE' BARNETT / Billy Loomis. 📌

… ♡⠀GLORY SITALI / Stu Macher. 📌

⎯⎯⎯⎯⎯⎯⎯⎯⎯⎯⎯⎯⎯⎯⎯⎯⎯⎯⎯⎯⎯⎯⎯⎯⎯⎯⎯⎯⎯⎯⎯⎯⎯⎯⎯⎯⎯⎯⎯⎯⎯⎯⎯⎯⎯⎯⎯⎯⎯⎯⎯⎯⎯⎯⎯⎯⎯⎯⎯

🔪 ┆ 𝗦𝗖𝗥𝗘𝗔𝗠 (𝟮𝟬𝟮𝟮).

… ♡⠀MELINA BATES / Amber Freeman. 📌

… ♡⠀LOURDES 'YVIE' ROMERO / Liv McKenzie. 📌

… ♡⠀MORGAN FOX / Richie Kirsch. 📌

… ♡⠀DEVON ECHOLS / Tara Carpenter. 📌

⎯⎯⎯⎯⎯⎯⎯⎯⎯⎯⎯⎯⎯⎯⎯⎯⎯⎯⎯⎯⎯⎯⎯⎯⎯⎯⎯⎯⎯⎯⎯⎯⎯⎯⎯⎯⎯⎯⎯⎯⎯⎯⎯⎯⎯⎯⎯⎯⎯⎯⎯⎯⎯⎯⎯⎯⎯⎯⎯

🔪 ┆ 𝗔 𝗡𝗜𝗚𝗛𝗧𝗠𝗔𝗥𝗘 𝗢𝗡 𝗘𝗟𝗠 𝗦𝗧𝗥𝗘𝗘𝗧 (𝟮𝟬𝟭𝟬).

… ♡⠀SERAINA DA SILVA / Jesse Braun. 📌

[montecristohq]

what other fictional characters remind you of your characters? it helps me have a better idea what you're looking for

omg i love questions like this ! after much deliberation, harper & i have decided :

CAMILLE : april ludgate , 'parks & rec'. carmilla , 'carmilla'. sideny prescott , 'scream'. MILO : glen lantz , 'nightmare on elm street'. kevin ball , 'shameless'. richie tozier , 'it'. KODY : jess day , 'new girl'. riley , 'ikwydls'. portia , 'white lotus'. REEVE : andy bernard , 'the office'. randy meeks , 'scream'. billy hargrove , 'stranger things'. ISLA : rory gilmore , 'gilmore girls'. luna lovegood , 'harry potter'. carrie white , 'carrie'. KINGSTON : chad meeks-martin , 'scream 5'. stanford pines , 'gravity falls'. steve harrington , 'stranger things'. ELIZA : jackie taylor , 'yellowjackets'. jennifer check , 'jennifer's body'. tatum riley , 'scream'. THOMAS : stiles stilinksi , 'teen wolf'. nick miller , 'new girl'. richie kirsch , 'scream 5'.

[healthbeautytips121]

Respiratory illnesses on the rise across U.S. as millions gather for holiday weekend

As millions of people gather for the holiday weekend, health officials are reporting that respiratory illnesses are on the rise. The Centers for Disease Control and Prevention said weekly flu hospital admissions are increasing and Covid-19 cases are also rising across the United States. NBC News’ Jesse Kirsch reports Watch Video

[treatnow]

Neuropathologic and Clinical Findings in Young Contact Sport Athletes Exposed to Repetitive Head Impacts

August 28, 2023 Ann C. McKee, MD1,2,3,4,5,6,7; Jesse Mez, MD, MS2,3; Bobak Abdolmohammadi, BA2; et alMorgane Butler, BSc2,8; Bertrand Russell Huber, MD, PhD1,2,3,5,6; Madeline Uretsky, MS2; Katharine Babcock, PhD2,8; Jonathan D. Cherry, PhD1,2,4; Victor E. Alvarez, MD1,2,3,5; Brett Martin, MS2,9; Yorghos Tripodis, PhD2,7,9; Joseph N. Palmisano, MS2,9; Kerry A. Cormier, BA1,2,5; Caroline A. Kubilus, BA2,5; Raymond Nicks, MS1,2,3,5; Daniel Kirsch, BA2,4; Ian Mahar, PhD2; Lisa McHale, EdS2,10; Christopher Nowinski, PhD2,10; Robert C. Cantu, MD2,10,11,12; Robert A. Stern, PhD2,3,12; Daniel Daneshvar, MD, PhD2,13; Lee E. Goldstein, MD, PhD2,14,15; Douglas I. Katz, MD3,16; Neil W. Kowall, MD2,3; Brigid Dwyer, MD3,16; Thor D. Stein, MD, PhD1,2,4,5; Michael L. Alosco, PhD2,3 Author Affiliations Article Information JAMA Neurol. Published online August 28, 2023. doi:10.1001/jamaneurol.2023.2907   Audio (16:39) Neuropathologic and Clinical Findings in Athletes With Repetitive Head Impacts  

Key Points

Question  What are the neuropathologic and clinical findings in a convenience sample of young, deceased, symptomatic contact sport athletes? Findings  In this case series of 152 contact sport athletes younger than 30 years at the time of death, chronic traumatic encephalopathy (CTE) was found in 63 (41.4%), with nearly all having mild CTE (stages I and II). Neuropathologic abnormalities associated with CTE included ventricular enlargement, cavum septum pellucidum, thalamic notching, and perivascular pigment–laden macrophage deposition in the frontal white matter. Meaning  These findings confirm that CTE and other brain pathologies can be found in young, symptomatic contact sport athletes, but the clinical correlates of these pathologic conditions are uncertain.

Abstract

Importance  Young contact sport athletes may be at risk for long-term neuropathologic disorders, including chronic traumatic encephalopathy (CTE). Objective  To characterize the neuropathologic and clinical symptoms of young brain donors who were contact sport athletes. Design, Setting, and Participants  This case series analyzes findings from 152 of 156 brain donors younger than 30 years identified through the Understanding Neurologic Injury and Traumatic Encephalopathy (UNITE) Brain Bank who donated their brains from February 1, 2008, to September 31, 2022. Neuropathologic evaluations, retrospective telephone clinical assessments, and online questionnaires with informants were performed blinded. Data analysis was conducted between August 2021 and June 2023. Exposures  Repetitive head impacts from contact sports. Main Outcomes and Measures  Gross and microscopic neuropathologic assessment, including diagnosis of CTE, based on defined diagnostic criteria; and informant-reported athletic history and informant-completed scales that assess cognitive symptoms, mood disturbances, and neurobehavioral dysregulation. Results  Among the 152 deceased contact sports participants (mean age, 22.97 years; 141 male) included in the study, CTE was diagnosed in 63 (41.4%; median age, 26 years). Of the 63 brain donors diagnosed with CTE, 60 (95.2%) were diagnosed with mild CTE (stages I or II). Brain donors who had CTE were more likely to be older (mean difference, 3.92 years; 95% CI, 2.74-5.10 years) Of the 63 athletes with CTE, 45 (71.4%) were men who played amateur sports, including American football, ice hockey, soccer, rugby, and wrestling; 1 woman with CTE played collegiate soccer. For those who played football, duration of playing career was significantly longer in those with vs without CTE (mean difference, 2.81 years; 95% CI, 1.15-4.48 years). Athletes with CTE had more ventricular dilatation, cavum septum pellucidum, thalamic notching, and perivascular pigment-laden macrophages in the frontal white matter than those without CTE. Cognitive and neurobehavioral symptoms were frequent among all brain donors. Suicide was the most common cause of death, followed by unintentional overdose; there were no differences in cause of death or clinical symptoms based on CTE status. Conclusions and Relevance  This case series found that young brain donors exposed to repetitive head impacts were highly symptomatic regardless of CTE status, and the causes of symptoms in this sample are likely multifactorial. Future studies that include young brain donors unexposed to repetitive head impacts are needed to clarify the association among exposure, white matter and microvascular pathologic findings, CTE, and clinical symptoms.

Introduction

Across the world, millions of people are exposed to repetitive head impacts (RHIs) through participation in contact and collision sports, military service, physical violence, and many other activities.1-6 Repetitive head impacts can result in symptomatic concussions and the much more frequent, nonconcussive injuries that are asymptomatic.7 Sustained exposure to RHIs can produce persistent cognitive and neuropsychiatric symptoms8-11 and a progressive, tau-based neurodegenerative disease, chronic traumatic encephalopathy (CTE).12-21 Multiple studies13,15,22 link a longer duration of RHI exposure in US football players with increased odds for the presence of CTE and increased severity of CTE. In older American football players with pathologically diagnosed CTE, RHI exposure is also associated with white matter rarefaction,23-25 loss of myelin associated proteins,26 and oligodendrocyte loss.27 Emerging data show structural white matter alterations on magnetic resonance imaging (MRI) in young, active, and recently retired contact sport players exposed to RHI,1,2,28-30 although the pathologic condition underlying these changes is unclear. A definitive diagnosis of CTE requires neuropathologic evidence of perivascular hyperphosphorylated tau (p-tau) aggregates in neurons, with or without astrocytes, typically at the depths of the sulci in the cerebral cortex.31,32 The clinical syndrome associated with CTE is known as traumatic encephalopathy syndrome (TES).8,33 On the basis of the National Institute of Neurological Disorders and Stroke (NINDS) consensus diagnostic criteria for TES,8 the core clinical features of TES include cognitive impairment, especially episodic memory and executive dysfunction, and neurobehavioral dysregulation, such as impulsivity, explosivity, and emotional dysregulation.8 Supportive features include delayed onset (ie, core clinical features starting years after RHI exposure ends), parkinsonism, other motor signs (including amyotrophic lateral sclerosis), depression, anxiety, apathy, and paranoia. The Understanding Neurologic Injury and Traumatic Encephalopathy (UNITE) Brain Bank1 has harvested brains from more than 1350 donors exposed to RHIs who are considered at risk for CTE. Brain donors in the UNITE bank vary widely in age at death and include teenagers and young adults. Chronic traumatic encephalopathy has been reported in individuals as young as 17 years,13 yet, to date, there have been no large-scale neuropathologic and clinical studies of young individuals exposed to RHIs. Attention to this age group has several important implications. The study of young athletes allows insight into the earliest features of RHI-induced neuropathologic injury and CTE. Furthermore, it allows analysis in the absence of common age-associated comorbidities. Moreover, most of these young contact sport athletes played only at amateur levels, as part of teams affiliated with educational institutions; consequently, the study of young athletes adds to our understanding of the long-term consequences of amateur contact sports participation. In this report, we describe the neuropathologic and clinical features of 152 brain donors from the UNITE brain bank who were younger than 30 years at the time of death.

Methods

Brain Donors and Study Design The initial sample for this case series included 156 deceased individuals with a history of exposure to RHIs from contact sports participation who donated their brain to the UNITE Brain Bank from February 1, 2008, to September 31, 2022, and were younger than 30 years at the time of death. Race was determined by next-of-kin report and was included to understand the representativeness of the sample and the associated generalizability of the results. Procedures of brain donation have been previously described.14,34 The inclusion criterion was based on the presence of a history of exposure to RHIs without regard to symptom status. The restriction to brain donors younger than 30 years was selected to minimize any contribution from age-related conditions. Donors were excluded for poor tissue quality. Four donors were excluded because of incomplete brain fragments or prolonged premortem hypoxia, resulting in a final sample size of 152. Institutional review board approval for brain donation, postmortem clinical record review, interviews with informants, and neuropathologic evaluation was obtained through the Boston University Medical Campus and the Veterans Affairs Bedford Institutional Review Board. The next of kin or legally authorized representative of each brain donor provided written informed consent. The methods for this report followed the appropriate use and reporting of uncontrolled case series in the medical literature reporting guidelines.35

Neuropathologic Evaluation

Neuropathologic evaluation occurred blinded to the clinical evaluation by neuropathologists (A.C.M., B.R.H., V.E.A., and T.D.S.). Pathologic processing and evaluation were conducted using previously published methods and as described in the eAppendix in Supplement 1.12-14,34,36 Neuropathologic diagnoses were made using NINDS National Institute of Biomedical Imaging and Bioengineering criteria for CTE31,32 and well-established criteria for other neurodegenerative diseases.37-40 The CTE p-tau pathologic findings were classified into 4 stages using the McKee staging scheme for CTE. Read the full article

[designmiss]

Gubble Bum https://www.design-miss.com/gubble-bum/ “Gubble Bum” disegnato da Jesse Kirsch, è un packaging per le confezioni di gomma da masticare. Sotto la bizzarra e colorata parte esterna si trova una sorpresa inaspettata: la rimozione […]

[hotpotoss]

Muhabir, Ian'dan sonra Orlando sel sularında yüzen timsahı gördü

Muhabir, Ian’dan sonra Orlando sel sularında yüzen timsahı gördü

Bir timsah, Ian Kasırgası’nın ardından Orlando’daki bir yerleşim sokağında yüzerken ortaya çıktı. NBC News muhabiri Jesser Kirsch, Cuma günü Florida’daki sel ve yıkımı haber yaparken hayvanı gördü. Kirsch, “Ne zaman sel baskınlarını kontrol etsek, sulara girmek istemediğinizi her zaman vurgulamaya çalışıyoruz” dedi. “Bu, suya girmemeniz için iyi bir neden.” NBC News’den Jesse Kirsch, Orlando,…

[moviesycho]

"And I ain't tryna mess with your self-expression, but I've learned a lesson that stressin' and obsessin' 'bout somebody else is no fun. And snakes and stones never broke my bones"

Taylor Swift - You Need to Calm Down (2019) dir. Drew Kirsch, Taylor Swift

[jamezvaldes]

Elsa Kirsch as Elsa for @chlobenet For the Costume Party hosted by @ocappreciation

[hybridanafrost]

Black Clover OC: Jessamy Hannan

"Babe, wake up. A new Black Clover OC just dropped!"

Jokes aside, Jessamy is just a minor character. Because the Coral Peacocks don't have enough girls on the squad, I decided to make another female OC for the heck of it.

Name: Jessamy Hannan (friends call her Jess or Jessy)

Age: 18

Birthday: February 27

Sign: Pisces

Squad: Coral Peacocks

Grimoire: Three Leaf Clover ☘️

Magic: Scent Magic

Eyes: Magenta

Hair: Dark brown

Jessamy is one of the 3 youngest recruits to join the Coral Peacocks. She is a commoner from a large family with 5 siblings. She makes her own soaps, candles, and perfumes using her magic. On her way to sell her goods at the market, she came across a group of injured magic knights. She opened up her grimoire and performed recovery magic in the form of scented candles. The knights she healed were Coral Peacocks who thanked her for her assistance. They purchased some of her sweet smelling goods and left. The next day she was graced by the radiant presence of their Vice Captain Kirsch Vermillion. He thanked her for healing his squad members and complimented her on her lovely face. However, his main reason for seeing her in person was to experience more of her beautiful fragrances. Kirsch told her their squad could use a healing mage and it would pay consistently to help out her poor family. Jessamy agreed and became the resident healer of the Coral Peacocks from that day forward. She would accompany her squadmates on missions and offer support with certain smells to weaken enemies or make her companions stronger and faster. She can also soothe nerves with aroma therapy before and after a big mission.

She started around the same time Wrenly Zamir and Aran Tirus joined. Because they were all so close in age, they became great friends. Since they all needed guidance and training for field work, they were assigned Bianca Schneider as their mentor. Bianca was a strict teacher and could be very hard on them whenever they made mistakes. Jessamy didn't appreciate Bianca's lessons in the beginning. That changed after the elf attacks ravaged their kingdom. She realized Bianca pushed them so hard in order to avoid any loss of life on the battlefield. Jessamy and her friends survived that night despite having slim chance of survival all thanks to dumb luck and what they had been taught. Jessamy began to take training and Bianca's criticism much more seriously after that.

Jessamy is a bubbly young lady with a kind and nurturing heart. Like a true social butterfly, she has friends in and out of her squad. Jessamy often likes networking through her friends in order to sell her goods. She spends most of her time in the kitchen of the Coral Peacock base watching Wrenly cook. In the beginning, it was all to practice copying the scents of Wren's food into candles. Wrenly became comfortable around her enough to talk and a close rapport formed. They bonded over being commoners on a squad of mostly nobles. Eventually these two could talk about anything for hours uninterrupted. Aran teases the two "lovebirds" and tries setting them up on dates with Kirsch's help. They both insist that they are just good friends. Although shy about it, Jessamy does fall madly in love with Wren. She secretly dreams of marrying them and eating their cooking for the rest of her life.

For Wrenly, Aran, and Bianca's bios, click below: