#Immunity and vaccinations

[aashiqeddiediaz]

you know what boils my blood.

over the last 2 weeks, i've seen countless patients walk into my urgent care center, symptomatic for so many things, refusing to get tested for covid and flu, citing that they don't want to knowingly bring it to their holiday tables. i had a patient tell me, verbatim, "i don't want to test for covid, because i don't want to be the asshole who brings it on a plane."

i understand that - i understand that holidays are times where people look forward to meeting loved ones that they might only see once a year, or where they get a break from the hectic back and forth of their lives.

but here's the thing - whether they get tested or not, they will bring whatever they have to their holiday tables. it's pure recklessness to know that you're sick, and walk into someone else's house spreading the disease.

today, january 2, i saw 91 patients, many of them who have tested positive for covid and flu. many of these patients are the same ones who didn't want testing 3 days ago, until their events were over, and now, they will have to reach out to everyone they know to let them know that they were positive because they were showing symptoms well before their event.

the next week or two? we're going to see many, many more, all people with symptoms that started around christmas. these are the only two viruses we test for rapidly in our office, but they are potent and can be fatal in many people.

so here's why i wrote this post, and maybe it's a little late, but - if you care about your loved ones, please get tested if you know you're sick. it doesn't have to be at a clinic if you don't want it to, because the over-the-counter tests work just fine too (if you test within 5-7 days of symptom onset). just...please don't try to run from the knowledge that you might have covid, because immunocompromised people, elderly people, people with co-morbidities like asthma, pregnancy, diabetes, etc...many of them may not recover. and they may not be sitting at your holiday table in the future because of it.

[giorgio52fan]

Uncertain Horizon: Will the COVID School Years Return Amid New Variants?

The relentless specter of COVID-19 continues to cast a shadow over the education landscape. As the world grapples with the ever-evolving variants of the virus, the question on everyone’s mind is whether the COVID school years will return. Despite the optimism of public health officials and the reassurances regarding the efficacy of tests and vaccines against new variants, a critical examination…

[reasonsforhope]

"Since it was first identified in 1983, HIV has infected more than 85 million people and caused some 40 million deaths worldwide.

While medication known as pre-exposure prophylaxis, or PrEP, can significantly reduce the risk of getting HIV, it has to be taken every day to be effective. A vaccine to provide lasting protection has eluded researchers for decades. Now, there may finally be a viable strategy for making one.

An experimental vaccine developed at Duke University triggered an elusive type of broadly neutralizing antibody in a small group of people enrolled in a 2019 clinical trial. The findings were published today [May 17, 2024] in the scientific journal Cell.

“This is one of the most pivotal studies in the HIV vaccine field to date,” says Glenda Gray, an HIV expert and the president and CEO of the South African Medical Research Council, who was not involved in the study.

A few years ago, a team from Scripps Research and the International AIDS Vaccine Initiative (IAVI) showed that it was possible to stimulate the precursor cells needed to make these rare antibodies in people. The Duke study goes a step further to generate these antibodies, albeit at low levels.

“This is a scientific feat and gives the field great hope that one can construct an HIV vaccine regimen that directs the immune response along a path that is required for protection,” Gray says.

-via WIRED, May 17, 2024. Article continues below.

Vaccines work by training the immune system to recognize a virus or other pathogen. They introduce something that looks like the virus—a piece of it, for example, or a weakened version of it—and by doing so, spur the body’s B cells into producing protective antibodies against it. Those antibodies stick around so that when a person later encounters the real virus, the immune system remembers and is poised to attack.

While researchers were able to produce Covid-19 vaccines in a matter of months, creating a vaccine against HIV has proven much more challenging. The problem is the unique nature of the virus. HIV mutates rapidly, meaning it can quickly outmaneuver immune defenses. It also integrates into the human genome within a few days of exposure, hiding out from the immune system.

“Parts of the virus look like our own cells, and we don’t like to make antibodies against our own selves,” says Barton Haynes, director of the Duke Human Vaccine Institute and one of the authors on the paper.

The particular antibodies that researchers are interested in are known as broadly neutralizing antibodies, which can recognize and block different versions of the virus. Because of HIV’s shape-shifting nature, there are two main types of HIV and each has several strains. An effective vaccine will need to target many of them.

Some HIV-infected individuals generate broadly neutralizing antibodies, although it often takes years of living with HIV to do so, Haynes says. Even then, people don’t make enough of them to fight off the virus. These special antibodies are made by unusual B cells that are loaded with mutations they’ve acquired over time in reaction to the virus changing inside the body. “These are weird antibodies,” Haynes says. “The body doesn’t make them easily.”

Haynes and his colleagues aimed to speed up that process in healthy, HIV-negative people. Their vaccine uses synthetic molecules that mimic a part of HIV’s outer coat, or envelope, called the membrane proximal external region. This area remains stable even as the virus mutates. Antibodies against this region can block many circulating strains of HIV.

The trial enrolled 20 healthy participants who were HIV-negative. Of those, 15 people received two of four planned doses of the investigational vaccine, and five received three doses. The trial was halted when one participant experienced an allergic reaction that was not life-threatening. The team found that the reaction was likely due to an additive in the vaccine, which they plan to remove in future testing.

Still, they found that two doses of the vaccine were enough to induce low levels of broadly neutralizing antibodies within a few weeks. Notably, B cells seemed to remain in a state of development to allow them to continue acquiring mutations, so they could evolve along with the virus. Researchers tested the antibodies on HIV samples in the lab and found that they were able to neutralize between 15 and 35 percent of them.

Jeffrey Laurence, a scientific consultant at the Foundation for AIDS Research (amfAR) and a professor of medicine at Weill Cornell Medical College, says the findings represent a step forward, but that challenges remain. “It outlines a path for vaccine development, but there’s a lot of work that needs to be done,” he says.

For one, he says, a vaccine would need to generate antibody levels that are significantly higher and able to neutralize with greater efficacy. He also says a one-dose vaccine would be ideal. “If you’re ever going to have a vaccine that’s helpful to the world, you’re going to need one dose,” he says.

Targeting more regions of the virus envelope could produce a more robust response. Haynes says the next step is designing a vaccine with at least three components, all aimed at distinct regions of the virus. The goal is to guide the B cells to become much stronger neutralizers, Haynes says. “We’re going to move forward and build on what we have learned.”

-via WIRED, May 17, 2024

[so-true-overdue]

Vaccines: The Unsung Heroes of Modern Medicine

Imagine a world where smallpox still reigned supreme, where polio paralyzed thousands annually, and where measles was a rite of passage, sometimes fatal. Yet, here we are, in a world where vaccines have valiantly vanquished these threats.

The paramountcy of vaccines in the annals of medical triumphs cannot be overstated. They are the quintessence of human ingenuity, a testament to our ability to combat nature's most insidious adversaries. Through the meticulous administration of vaccines, we have consigned diseases like smallpox to the historical archives and reduced the scourge of polio to a mere whisper in the annals of modern afflictions.

Statistically, the efficacy of vaccines is irrefutable. The World Health Organization estimates that vaccines prevent 2-3 million deaths annually. Consider the measles vaccine: a marvel of medical science that has reduced global measles deaths by 73% between 2000 and 2018. Similarly, the introduction of the polio vaccine has brought the incidence of polio down by 99%, from 350,000 cases in 1988 to just 33 reported cases in 2018.

Yet, amidst this triumph, there exists a cacophony of dissent. The sanctimonious detractors, draped in the garb of skepticism, pontificate about the perils of vaccination. They brandish anecdotes of adverse reactions as if they were incontrovertible evidence, ignoring the overwhelming preponderance of scientific data. Yes, vaccines, like all medical interventions, are not devoid of risks. However, the incidence of serious adverse reactions is exceedingly rare. The Centers for Disease Control and Prevention notes that severe allergic reactions occur in about 1 in a million doses of vaccines. To put this in perspective, the likelihood of being struck by lightning in any given year is approximately 1 in 500,000—twice as likely as experiencing a severe vaccine reaction.

The irony is palpable. The very individuals who eschew vaccines on the grounds of potential harm are often the beneficiaries of the herd immunity afforded by the vaccinated majority. Their sanctimony is not only misplaced but perilously undermines public health efforts. The resurgence of measles in recent years, driven by declining vaccination rates, is a stark reminder of the consequences of such misguided dogma.

In conclusion, vaccines are the silent sentinels, safeguarding humanity against the ravages of infectious diseases. Their unparalleled efficacy, coupled with an exceptionally low incidence of adverse reactions, renders the anti-vaccine rhetoric not only scientifically unfounded but also morally untenable. The sanctimonious naysayers, in their misguided zeal, imperil the very fabric of our collective health. Let us, therefore, celebrate vaccines for what they truly are: the unsung heroes of modern medicine.

[iamnmbr3]

vaccines are so cool. i love how it's like

Vaccine: hey see this guy?

Immune system: yeah?

Vaccine: this guy sucks. remember him. he wants to make you sick.

Immune system: he what?! If I ever see him again he's gonna catch these hands.

Vaccine: good!

*

Actual illness the vaccine was for: hey! 😈 

Immune system: OMG! ITS HIM! IT'S THE GUY! PREPARE TO GET WREKT MF!!!!!!!

[total-drama-brainrot]

i now wanna hear your very long character analysis on how the drama machine affected alejandro

Yeah alright.

So I haven't actually watched All-stars, but I did skim through this video to get a feel for Alejandro's characterisation in it, since All-stars is the only canonical material we get from Alejandro post Drama Machine.

And by skim I really do mean skim; I was mostly looking out for signs of his imprisonment's influence, which for the most part seems to be as follows:

His legs fell asleep.

He developed a minor case of agoraphobia, mostly in the context of sleeping in open spaces.

His standards of human interaction have plummeted; something he's aware and accepting of.

Interestingly enough, he doesn't really seem to acknowledge the volcano itself (outside of an offhanded comment) or the injuries he got from the explosion. His focus is solely on his time in the suit, not what out him there in the first place. He even skirts over a memory loss issue, which could contribute to this.

I'll tackle these three points in more detail, and then give examples of how they can be developed into actual characterisation points instead of (for the most part) gags.

Number one; Leggy McLatin and the paraplegia scheme.

Alejandro's inadvertant and unintentional escape from the Drama Machine, and subsequent readmission into the competition (as himself, instead of as the machine) is, for the most part, entirely focal on the fact that his legs no longer work after his year of entrapment. It's a big deal - or, at least, as big of a deal as any injury or ailment can be in the context of Total Drama, considering that he doesn't miraculously get better in the span of an episode. Of course, we learn fairly early on that he's faking the paraplegia, but it's fairly heavily implied that his legs really were asleep initially (and that, in all likelihood, the massage we see him getting from an intern is what "wakes them up").

What's interesting about this particular plotline choice is that it would, realistically, be entirely feasable for Alejandro to have mobility issues after spending a year inside a robot.

Now, I'm no doctor, nor do I have any formal medical training, but I do know that not being able to move your body for an extended period of time results in a serious case of muscle atrophy. We see in canon that Alejandro was essentially locked in a seated position for the year; his arms, head and (assumedly) torso had place to move around, but he couldn't really stretch out his legs. This would explain the "weakness" of his legs in the first episode - i.e. their wobbliness, and the fact that they couldn't hold up Alejandro's body weight. The numbness he cites would be explained by poor circulation - again caused by him being sat down for a solid twelve months.

Or it could be nerve damage from the eruption, but given that Alejandro doesn't seem to have any long-term issues that stem from the volcano itself, it's unlikely.

So it can be assumed that the numbness of his legs was offset by the massage he gets after the first challenge. The masseuse kickstarts the blood circulation back into his legs, resulting in him regaining sensation in them - enough feeling to notice a crab pinching at his feet.

And, if I really want to reach into headcanon territory/realism, the reason he keeps up the "ruse" is because, despite having feeling in his legs, the muscles there are still fairly atrophied and he has a lot of trouble walking, let alone running, for extended periods of time. Though, as it stands, any long-term impact on his health would be entirely headcanon/fanon territory, due to the nature of the show itself.*

Then there's the psychological aspect to consider. Alejandro's a very prideful person by design - that's evident in both the way he portrays himself and the physical standards he holds himself to. Having use of half of his body stripped away from his is bound to be distressing, perhaps even traumatising. Hence why he tries to make himself as useful to the team as possible despite still recovering; he needs everyone to see that he's still capable.

Eventually his legs fully recover, because this is Total Drama and things like "realistic healing processes" and "lasting damage" don't seem to exist in-universe.

Number two; snug as a bug in a rug.

Alejandro's shown to have started sleeping in a sleeping bag throughout All-stars. He even canonically states that he needs to, because of his time in the Drama Machine. He cites that sleeping whilst srpawled out makes him uncomfortable, unspokenly referring to the fact that, for a year, he'd only had the option to sleep in an incredibly cramped position/environment.

This is interesting since, for the most part, you'd assume that someone held in close-quaters captivity would develop claustrophobia instead of a form of agorophobia, and yet Alejandro seems to have internalised the need to be in an enclosed space to sleep. Maybe it's symptom of just how long be was encased for - a year is a long time - or maybe it started out as claustrophobia, but the indefinate nature of his captivity morphed the initial fear into a twisted sort of coping mechanism.

It begs the question; what else can't Alejandro do in open spaces?

Is he perpetually uncomfortable with the openness of the outside world? Does he resort to hermiting himself into closed-off corners and enclosed rooms, just to feel a semblence of normalcy after he escapes the confines of the Drama Machine? Would he take to wearing tighter but more concealing clothing, just to immitate the feeling/pressure of being trapped in a too-tight enclosure?

Is his need for a snug sleeping space indicitive of him missing his isolated imprisonment?

Which brings us nicely into the third point.

Number three; long-term isolation and the effects thereof.

Alejandro explodes out of a glorified toaster and one of the first things he really comments on is Heather's off-putting personality and her facial hair. In a positive manner. He's so starved for human contact that he attaches himself to the first "friendly"/familiar face he sees, which in this case is Heather, and focuses on the aspects of her that make her human.

If he were a "weaker man", I have no doubt Alejandro would be clambering for attention from his team, mostly for proof that he's no longer completely isolated. It's a well-documented phenomenon; people who experience a long time in isolation, or who suffer through long periods of loneliness, become desperate for socialisation (and physical contact), to the point their immune systems and biological rhythyms (from circadian to infradian) start to deteriorate.

Realistically, Alejandro would've come out of the Drama Machine a desperate and sickly mess, riddled with insomnia and paranoia and incredibly touch-starved. But, as established, the show isn't exactly true-to-life when it comes to things like this, so...

As it stands, the fact that he emerged from his prison and immediately jumped back into his charming persona attests more to the fact that his flirtatious act is so deeply ingrained into his psyche than it does to his mental wellbeing. It could be argued that he's using the same act/mask/persona as a tether to his old self and an anchor to normalcy, as he'd likely crumble into an inconsolable mess without the scaffolding of his "TV personality" keeping him upright (metaphorically of course, as Alejandro is in fact not upright in the show. He's upside down for the majority of his time on All-stars).

Or maybe he's just built different? Who's to say.

We don't exactly know what went down during his year away, so it's impossible to make any concrete statements as to whether Alejandro was afforded the luxury of other people's company, or if he really was kept 100% isolated in the machine. The only thing we do know is that he likely had access to a phone, though didn't have the capability of using it without assistance, since he calls Heather out for never trying to contact him but also states the impossibility of him doing the same in turn.

Number four; lava damage and the lack thereof.

It's sort of explained during his scene at the end of World Tour, but Alejandro's whole "being trapped in the Drama Machine" deal - alongside being a parody of the scene where Anakin Skywalker is first put into the Darth Vader suit - is stated to be for his own benefit. He's essentially being locked away into a healing suit. Again, just like Anakin - they both even sport similar burn wounds.

He mentions at the beginning of All-stars that he doesn't really remember being put into the machine, and it's safe to assume that the majority of his time in the contraption is likely fuzzy to him as well; being fully concious of complete isolation for a whole year would be enough to drive anyone completely mad, and Alejandro is decidedly not insane (for the most part). Ergo, it's also a safe assumption that the inner mechanisms of the Drama Machine act as a sort of stoporous healing chamber, keeping Alejandro semi-concious and healing his various lava burns over the course of his concealment.

Sort of like a medical coma. Inside of a robot. A portable medical coma.

The "healing properties" would also justify why Alejandro's whole body hadn't deteriorated from muscle atrophy, or developed any (visible) burn scars from his stint in the Hot Sauce. Of course, as far as burn scars go, unless they're significantly deep they do tend to fade into near-invisibility over time. That, paired with the ~magical healing properties~ of his confinement, likely resulted in his lava burns scarring over into insignificance.

Then again, I once again have to take cartoon logic into account - the show itself likely just didn't consider the semi-realistic consequences of a year of entrapment, and wanted Alejandro to be near-enough the same character he was at the end of World Tour before the consequences™.

The main point here is this; Alejandro doesn't seem to remember the majority of his injuries following the volcano eruption in the World Tour finale, or if he does he's had a year of semi-conciousness to work through his thoughts and feelings on the matter, and as a result he doesn't seem to carry any (reasonable) trauma regarding lava, volcanoes, or other related stimuli.

He does, however, retain some "quirks" from his time in the machine.

Number five; an overview.

Alejandro comes out of the Drama Machine with a surprisingly little amount of visible trauma, both in terms of physical damage/scarring and observable mental changes.

He developed a very minor case of agoraphobia, spurned on by him becoming accustomed to existing in a very small, very cramped space, but otherwise attunes himself to the outside world incredibly fast.

Is this probably related to his social training, as a diplomat's son, and his heavy reliance on a "suave and charming" persona. He's likely battling with a lot of internal issues throughout the season, but squahing down his inner turmoil under his determination to win, which explains how/why he falls so easily into his scheming mindset - it, in and of itself, is a coping mechanism, though not a very healthy one.

*The paralysis of his legs was in all likelihood genuine, and a result of poor circulatory issues and minor muscular atrophy, which was almost immediately treated by the masseuse intern after the first challenge. Realistically (and how many times have I said that word) he'd have some lasting weakness in his legs, and maybe require the use of a mobility aid and/or physiotherapy. This is not the case, because... Total Drama.

There are subtle signs of the mental impact of his imprisonment, mostly in his immediate attachment to Heather (despite her taking away his reproduction privileges the last time they spoke, and her being Heather) and his innate need to prove himself as useful/capable despite his gameplan riding on him appearing pitiable and unthreatening (due to his "sleepy legs"). He's so starved for social interaction and validation that his actions are directly contradictory to his gameplans.

Though in the case of his Heather attachment, he could just be like that. He was also fairly infatuated with her in the latter half of World Tour, and the pineapple scene speaks for itself.

In conclusion; Alejandro is either completely goated and (for the most part) just shrugged off the trauma of being trapped in a tiny box for a year, or he was already so traumatised that the imprisonment was just another needle in his haystack of turmoil.

[mindblowingscience]

The discovery of a particular subgroup of antibodies may open the door to more effective dengue therapeutics and the development of a universal dengue vaccine. Dengue fever is a viral infection with a devastating twist: those who have caught it once are more likely to develop life-threatening disease the second time around. Why our bodies not only fail to learn from prior infection but also become more vulnerable as a result is a longstanding mystery that has prevented development of a universal dengue vaccine. Rather than protecting against disease, such a dengue vaccine could instead serve as a first exposure to prime the body for it. The new antibodies are those responsible for dengue’s increased deadliness upon second exposure. “We definitively proved that it’s not the presence of dengue antibodies that are a problem, but the quality of those antibodies,” says Stylianos Bournazos, a research associate professor in the laboratory of Jeffrey Ravetch, a professor at Rockefeller University. “Now that we know the pathway that these antibodies use, we can develop therapeutics against it.”

Continue Reading.

[lasseling]

[omg-snakes]

Chammers was named as a joke about a joke about a fulfillment platform software product that no longer exists.

Now I'm going to rehome him, and his new family will probably rename him. They won't know why he was ever called Chammers.

Will they even wonder?

[alanshemper]

9 April 2024

There are few groups so reviled in liberal circles as the anti-vaxxers. Seen as embarrassingly anti-science and anti-social to boot, the popular anti-vaxxer archetype is a shrill, loudly wrong grifter straight out of YouTube Medical School. They are not only uninformed, but dangerous. And their specific brand of ignorance invites a mocking condescension from those of us who self-identify as “educated” and “pro-science.”

There’s one big problem with liberal media outlets, individuals and institutions expressing this disdain today: they have, themselves, adopted many foundational beliefs of the anti-vax movement without even realizing it. While they express continued appreciation for vaccines, their underlying ideas about immune systems, illness, herd immunity, and the social value of public health have all aligned with anti-vaxxer ideology. I’ll unpack each of these foundational beliefs individually, but first I’d like to address why this has happened.

[...]

Herd immunity would mean long-term, durable protection from infection, like we have for viruses like measles, mumps, and rubella. This society-wide protection would then enable vulnerable people to rejoin society without constant risk of infection. But since reopening, COVID has circulated year-round at high levels and the population is continually getting reinfected. Both the Republican and Democratic strategies to achieve herd immunity were doomed from the start. There are a variety of biological reasons for this.

[davidaugust]

“Former President Donald J. Trump said on Sunday that he expected Robert F. Kennedy Jr. to have a ‘big role’ in a second administration, and acknowledged the possibility that he could take action against two major public health successes — vaccines and the fluoridation of water — if he won the presidency.”

“Mr. Trump…said at his recent rally in New York that he would let Mr. Kennedy ‘go wild on health,’ and on Sunday Mr. Kennedy reiterated to Fox News that he was in talks with Mr. Trump about a high-level policy role. ‘I want to be in the White House, and he has assured me that I’m going to have that,” Mr. Kennedy said.’”

https://www.nytimes.com/2024/11/03/us/politics/trump-rfk-jr-vaccines-fluoride.html

“He says, ‘If you give me the data, all I want is the data, and I’ll take on the data and show that it’s not safe.’ And then if you pull the product liability (protections), the companies will yank these vaccines right off, off of the market,” Lutnick said.

https://www.cnn.com/2024/10/31/politics/howard-lutnick-robert-f-kennedy-jr-vaccines-cnntv/index.html

[carnivalcarriondiscarded]

i may hate needles but i love vaccines more yeehaw

[feminist-space]

The swelling's not so bad.

It's the severe testicular pain...

Mumps means 9 days in isolation.

No parties. No friends. No classes.

Intense pain in cheeks and throat.

Difficulty chewing of swallowing

Weakness. Fever.

In some cases, severe pain and swelling of the testicles and ovaries.

Mumps can cause sterility, meningitis, and deafness.

The MMR vaccine provides the best protection against mumps.

Protect yourself against mumps.

Get VACCINATED.

Adapted with permission from the Province of Nova Scotia Department of Health and Wellness

For more information, call 2-1-1 or visit https://health.hawaii.gov

[so-true-overdue]

Ah, the delicate art of deception, Russia’s enduring magnum opus. In a world awash with superficial ephemera and algorithm-driven hysteria, it has emerged as a master puppeteer, manipulating the strings of disinformation to sow discord in the vulnerable Western psyche. The battlefield of choice? Social media platforms, of course—those gloriously fertile grounds where any unverified tweet or video clip can blossom into the viral infection of modern civilization.

Through meticulously crafted disinformation campaigns, Russia has weaponized truth, distorting it beyond recognition and serving it on a platter to the unsuspecting masses who consume it with insatiable gullibility. The irony is, while most of the Western world fancies itself intellectually superior, the very same platforms they created to exchange cat memes have now become tools of psychological warfare. And why wouldn’t they? What better way to dismantle a society than by first unraveling its understanding of objective reality?

Enter the antidote: verifiable journalism. Yes, that relic of an era when facts were sacrosanct and not merely alternative options on a drop-down menu. Only through rigorous, investigative journalism can we fortify the crumbling ramparts of reason against the onslaught of misinformation. In an age where everyone with a smartphone fancies themselves a beacon of truth, the numinous—a word traditionally reserved for spiritual transcendence—takes on new significance. It is through the sacred, almost mystical reverence for truth that we might reconnect with an epistemological certainty. The numinous, in this case, isn’t found in the divine but in the sheer act of seeking verifiable, unadulterated information—an endeavor that feels increasingly like an act of faith itself.

Yet, the dissonance remains palpable. Instead of scrolling through rigorously researched articles, many remain transfixed by whatever ideological poison is peddled by the latest bot, leaving the defenses of reason to rot. Because, after all, who needs journalistic integrity when you have a meme to confirm your worldview?

In this grim theater of cognitive warfare, it is not weapons but narratives that determine the victor. And unless we are willing to hold up verifiable journalism as the last bastion of intellectual integrity, the West may find itself losing more than just a few online arguments. It could lose the very essence of reality itself.

[imovyn]

love vaccinations like anytime im at the doctor and theyre like hey youre due for a shot do you want it im like hell yeagh stick that thang in me

[didanawisgi]

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