#Histamine N-Methyltransferase | Explore Tumblr posts and blogs

lenaglittleus · 6 years ago

Text

Histamine Intolerance Treatment And The Role Of Single Nucleotide Polymorphisms

Histamine intolerance treatment must go beyond treating just the symptoms!

Histamine is the itchiest molecules in our body! When histamine is released in the skin, its job is to dilate blood vessels causing redness to the skin, swelling, and of course itching. In the nasal mucosa, it causes a runny nose, sneezing, and that stuffy feeling we just cannot stand during allergy and cold/flu season.

But what happens if histamine is over released or cannot be cleared out of the system? Typically occurring in women (due to the relationship of estrogen with histamine) this issue can be devastating and life altering. We are going to go in-depth and discuss an under-diagnosed condition called Histamine Intolerance. This is not an approved medical diagnosis as of yet so it doesn’t have an ICD-10 code nor does this get taught in conventional medical schooling.

Why could that be? There are many new tests and technologies that have emerged to help identify and treat patients with aims to treat the cause of symptoms rather than matching a drug to turn off a patient’s symptom(s). Naturopathic and Functional Medicine is quickly becoming the saving grace to people who have these unexplained symptoms or who have been lumped into garbage bucket diagnoses called syndromes such as POTS, MCAS, IBS, Fibromyalgia, and so many more.

Human physiology is a complex interaction of the inherent genetics as expressed by the individual given environmental conditions and cellular aging. To begin understanding the framework in which we will grasp this complex information, we will start with the basics. Now, if you are more advanced in cell biology or physiology, please use this as a friendly review.

Genetics

Genes are the “sentences” within our DNA that code for proteins. There are other segments within our DNA that act as spacers, modifiers, and bookends to the plethora of “sentences” in the code; totaling over 23,000 genes.

Depending on the signals to the genes within the nucleus of our cells and mitochondria, certain genes are turned on and off accordingly. The environment, thoughts, hormones, diet, exercise, infection, etc. are all factors that signal genes to turn on/off.

Every cell is on a certain cycle of growth, rest, and programmed death called apoptosis (a healthy cell). Turning on and off genes is done by a process called methylation. This is the movement of a single carbon and 3 hydrogen atoms called a methyl group (CH3) on or off of a gene’s switch.

Methylation is not solely for gene switching, but for other incredible functions within the body and metabolism. This modification of gene expression is called Epigenetics. Epigenetics happens in an individual and can be passed down from grandmothers to their grandchildren. Let’s take a deeper dive into all of these functions.

Methylation

Methylation is the process of transferring a single carbon group to other larger molecules. There are enzymatic pathways that produce intermediate agents such as SAMe, and these in turn provide the necessary cofactors for other enzymes to function. Neurotransmitter, nucleic acid, amino acid, and hormone synthesis as well as lipid breakdown, heavy metal detoxification, and other elimination pathways all need this important process to work properly.

Histamine Intolerance Treatment And Single Nucleotide Polymorphism (SNP’s)

As stated previously, genes are like a sentence, composed of many letters and phrases. But what happens when a single letter changes in the sentence “The dog dug a hole” to “The dug dug a hole”?

This can create a problem with the function of the final protein. There are structural changes that are impacted from mutations such as the collagen disease called EDS (Ehlers-Danlos Syndrome), classically characterized by varying degrees of hyper-flexible joints and elastic skin; or the “poster child” of the SNP world called the MTHFR mutation impacting the way in which we use folate (B9) and B12.

Many mutations can have no impact at all, some very little, and some quite severe in symptomatology. Other mutations in the genetic code that are even more severe cause death of the embryo and the pregnancy will end by the 10th-12th week in miscarriages.

Some mutations can give special advantages to an individual and if that has a natural benefit over another in a given population, that gene is passed on. Over time in a given population, this will increase in frequency, and we call this evolution.

SNPs are very common so please do not think that you are a mutant, in fact we all are. However, if an individual is having difficulties with their health that are beyond what classically are taught in medical school, these people often go many years or decades with dysfunction.

Hence there is a need for better education, awareness, and continued research to discover more about SNPs and their function.

Histamine

From the parent amino acid histidine, histamine is a very important signal within the body. In the figure below, you can see It has a function in just about every organ and tissue within the body.

Histamine is broken down by 2 enzymes:

1. DAO (diamine oxidase)

2. HNMT (histamine N-methyltransferase) SAMe cofactor dependent

The term histamine intolerance is better understood by a problem with the consumption of and release of excess histamine compounded with the body’s difficulty in regulation and breakdown of this signal. As mentioned above, there are many different minor causes that can compound synergistically creating a variable level of symptomatology.

CASE STUDY:

A 39-year-old female presents to the clinic with a 30 year history of symptoms including joint laxity, headaches, brain fog, dizziness, and heart palpitations. She has had many cardiologists, neurologists, rheumatologists, and even psychological counseling to treat the plethora of symptoms and give her diagnoses of the syndromes known as POTS (Postural Orthostatic Tachycardia Syndrome)and MCAS (Mast Cell Activation Syndrome). She was given Botox for her migraines, cardiovascular medications to control her heart rate, and drugs to keep her other histamine symptoms in check.

Upon analysis of her genetic SNPs, numerous genetic polymorphisms were identified impacting her ability to utilize B12, Folate, and B6 thereby decreasing her ultimate production of SAMe. Furthermore, the COMT enzyme which degrades neurotransmitters was also affected. When COMT is altered, it speeds up the clearance of noradrenaline and adrenaline.

Once identified, strict elimination of certain supplements and foods containing these ingredients was recommended along with the necessary end products of the metabolic cycles to aid in the ultimate delivery of what she had been deficient in for all these years. Her two week follow up was astonishing, as she reported her “lights went on” for the first time.

Her husband noticed the change within days of initiating the protocol and she had to decrease her cardiovascular drugs because they became too strong. She is now one-month post treatment start date and holding strong with increased energy, mental alertness, muscle strength, and of course a vitality boost that has given her the confidence and strength to contemplate returning to the work force versus going on permanent disability.

Summary

People who are afflicted with horrible symptoms do not have to be! There is an underlying cause that needs to be discovered. If one doctor doesn’t have any idea, keep searching.

Not all doctors are created equally, and with new research that comes out continuously, the reality of the way things are will get better. If you have been told you are crazy, lazy, or have a rare syndrome, STOP and seek out a doctor who will listen to you and get to the bottom of it ASAP.

The post Histamine Intolerance Treatment And The Role Of Single Nucleotide Polymorphisms appeared first on Source of Health: Functional And Regenerative Medicine.

from Source Of Health, LLC https://sourceofhealthllc.tumblr.com/post/184560017367

0 notes

sourceofhealthllc · 6 years ago

Text

Histamine Intolerance Treatment And The Role Of Single Nucleotide Polymorphisms

Histamine intolerance treatment must go beyond treating just the symptoms!

Genetics

Methylation

Histamine Intolerance Treatment And Single Nucleotide Polymorphism (SNP’s)

Hence there is a need for better education, awareness, and continued research to discover more about SNPs and their function.

Histamine

From the parent amino acid histidine, histamine is a very important signal within the body. In the figure below, you can see It has a function in just about every organ and tissue within the body.

Histamine is broken down by 2 enzymes:

1. DAO (diamine oxidase)

2. HNMT (histamine N-methyltransferase) SAMe cofactor dependent

CASE STUDY:

Summary

People who are afflicted with horrible symptoms do not have to be! There is an underlying cause that needs to be discovered. If one doctor doesn’t have any idea, keep searching.

The post Histamine Intolerance Treatment And The Role Of Single Nucleotide Polymorphisms appeared first on Source of Health: Functional And Regenerative Medicine.

0 notes

battybat-boss · 6 years ago

Text

Are Vaccines Linked to Increase in Mast Cell Disease and Allergies?

Mast Cell Disease and Vaccination: Is There Increased Risk?

by Barbara Loe Fisher and Carolyn Hendler The Vaccine Reaction

Do you or does someone you know have severe symptoms of itching, rashes, flushing, stomach or other body pain, frequent diarrhea, nausea, fatigue, brain fog, headache and severe allergies to certain foods, medications or insect stings that may include fainting episodes or anaphylaxis?

Although it has been classified as a rare immune system disorder, there are indications that Mast Cell Activation Syndrome (MCAS) may be more prevalent than previously thought and people can suffer for years without being correctly diagnosed.1

With severe allergies and chronic inflammatory diseases increasing in populations around the world, scientists are investigating the association between mast cell dysregulation and various brain and immune system disorders ranging from asthma, inflammatory bowel disease and chronic fatigue syndrome to ADHD, depression, autism and cancer.2 3 4 5

What are Mast Cells?

Mast cells are often described as the body's sentinels because they modulate and orchestrate the immune response and play a critical role in innate and adaptive immunity, as well as maintaining homeostasis in the body.6 7

Mast cells and basophils are types of white blood cells (granulocytes) that are made in the bone marrow. While basophils circulate in the blood, mast cells reside in tissues, primarily connective and mucosal tissues near blood vessels and nerves of the skin, gastrointestinal, respiratory and genitourinary tracts, and the brain.8 9

Mast cells and basophils are part of the body's first line of defense when responding to injury or foreign antigens, such as pathogenic bacteria, viruses, parasites, protozoa, fungi and toxins.10

During the immune system's normal protective response to a perceived threat, mast cells can release over 200 potent pro-inflammatory mediators within seconds of activation, including histamine (amino acid product), heparin (anti-coagulant), tryptase (enzyme) and cytokines (cell signaling protein molecules).11 12

The activation of this normal protective inflammatory response to internal or external stress increases blood flow to the site of the infection or wound to aid in healing. Acute inflammatory responses are often accompanied by the four classic signs of redness, heat, swelling and pain, which eventually disappear as cells regenerate and inflammation resolves during the healing process.13

However, allergic inflammatory responses are also provoked by mast cell activation.14

What is Mast Cell Disease and MCAS?

Mast cell activation is common and helps combat threats to our health. However, when a dysregulated immune system overproduces mast cells or when mast cell activation is out of proportion to the perceived internal or external threat, it can compromise our health.

The most serious of mast cell activation diseases (MCAD) is systemic mastocytosis, which can develop when genetically altered mast cells infiltrate and accumulate in large numbers in major organ systems, such as the skin, liver and intestines.15 16

A rare form of MCAD is aggressive systemic mastocytosis, usually caused by somatic mutations in the KIT gene, which progresses rapidly and causes organ damage and failure.17

An even rarer form of mast cell disease is mast cell leukemia and mast cell sarcoma.18

Mast Cell Activation Syndrome (MCAS) is a common variation of mast cell disease and can be more or less severe depending upon epigenetic, environmental, lifestyle and other host factors. MCAS occurs when a normal amount of mast cells inappropriately and chronically release histamine and other pro-inflammatory mediators that can lead to persistent inflammation in one or more parts of the body.

Over time, chronic inflammation can damage cells if inflammation cannot be resolved and every organ in the body can be affected.19

Systemic mastocytosis is estimated to affect 1 in 10,000 people. However, the prevalence of MCAS is not known and some researchers estimate the less serious forms of mast cell dysregulation could affect between 10 and 30 percent of populations.20 21

Symptoms of MCAS

Symptoms of MCAS can wax and wane and often various symptoms start in early childhood, although people generally do not get diagnosed for decades after symptoms appear. The effects of mast cell dysregulation can cause a plethora of diverse symptoms, depending on where the mast cells are activated in the body.

Common symptoms of MCAS can include fatigue; pruritus (severe itching); migraine; frequent nausea and diarrhea; allergic reactions to certain foods, medications, chemicals, insect bites and environmental antigens; chronic sinus congestion or dry cough; gastro-esophageal reflux disease (GERD); urinary tract infections; muscle cramping; feeling cold; sweating, especially at night; hair loss; dry eyes; conjunctivitis (pink eye); mouth ulcers (canker sores); dental decay; heart palpitations; inability to concentrate and brain fog; anxiety, depression and insomnia.22 23

When mast cells overeact to a benign substance as if it were a foreign antigen posing a serious threat, symptoms can be life threatening like when a person has an anaphylactic reaction to peanuts.24

Mast cell over-activation and release of large amounts of histamine in the body can be unpredictable, so people with MCAS are at risk of reacting to different foods, alcohol or medications at any time, leaving them uncertain as to when they might have another reaction to something they previously were not aware was a trigger for mast cell activation.25

Many people with MCAS carry an epi-pen with them in case of anaphylaxis.

Diagnosing mast cell disease is difficult and involves blood and urine testing and, less frequently, skin or bone marrow biopsy.26

Most medical doctors in general practice are not well informed about MCAS, while doctors specializing in functional medicine tend to be more familiar with symptoms.

Functional medicine focuses on a personalized, integrative approach to investigating root causes of health problems by analyzing the unique genetic, epigenetic, biochemical, environmental and lifestyle factors that affect an individual's immune function and influence the development of complex chronic diseases.

Because MCAS can present differently in different people, the goal is to identify individual triggers for mast cell activation, including food (such as gluten, dairy, baker's yeast, shellfish, nuts, wheat, corn); or chemicals (alcohol, certain prescription medications, MSG, aspartame, artificial dyes, cleaning products); mold and spores; extreme heat or cold; vigorous exercise; stress or other potential triggers and avoid them.27

There are many unanswered questions about mast cell disease and few prescription drug treatments.28

There is evidence that certain flavonoids (such as Quercetin and Rutin) inhibit histamine release and expression of pro-inflammatory cytokines in mast cells. 29

MCAS and Chronic Disease

Because overactive mast cells release pro-inflammatory mediators causing widespread inflammation in the body, MCAS has been implicated in a number of diseases that involve chronic inflammation and immune dysfunction. There is evidence that MCAS is related to allergic/inflammatory diseases, autoimmune disorders, and autism spectrum disorder.30 31

Health problems that have been associated with MCAS include eczema, psoriasis, and other skin disorders; irritable bowel syndrome; small intestine bowel overgrowth (SIBO); interstitial cystitis (bladder pain syndrome); asthma; migraines; depression; anxiety; ADHD; Obsessive Compulsive Disorder (OCD); autoimmune diseases like rheumatoid arthritis, lupus and Hashimoto's; cancer; peripheral neuropathy, multiple sclerosis; diabetes; obesity; endometriosis; infertility; fibromyalgia and postural orthostatic tachycardia syndrome (POTS), among others.32 33 34

Symptoms of Histamine Intolerance

Histamine is a neurotransmitter that facilitates communications between neurons throughout the nervous system. Histamine levels in the body help control the sleep and wake cycle and influence metabolism, thyroid function, reproduction and management of stress, as well as regulate body temperature, maintain fluid balance in the body and other important functions. Histamine can also increase permeability of the blood brain barrier.35

People with histamine intolerance lack sufficient levels of Diame oxidase (DAO), a gut enxyme, and histamine N-methyltransferase (HNMT), a liver enzyme, which break down and detoxify histamine in foods, medications or alcohol. When these enzymes fail to do their job, high levels of histamine circulate in the blood and cause histamine intoxication.36

Eating histamine-rich foods, drinking alcohol or taking prescription drugs that release histamine and or inhibit DAO or HNMT enzyme activity can cause high histamine levels and symptoms like diarrhea, headache, sinus congestion, heart palpitations, itching and flushing, low blood pressure and many other symptoms.

The symptoms of histamine intolerance and MCAS are similar and a person can have either histamine intolerance of MCAS or both. The main difference between the two is that histamine intolerance involves the triggering of high levels of histamine in the blood that cannot be efficiently detoxified, while MCAS involves dysregulated mast cells releasing not only histamine but multiple inflammatory and other types of mediators in tissues of the body.37

There is some evidence for genetic predisposition to histamine intolerance. Like MCAS, histamine intolerance can be hard to diagnose even with blood and urine tests. Treatment for histamine intolerance focuses on avoiding histamine rich foods and alcohol or medications that block DAO or HNMT enzyme activity.

Some people with histamine intolerance take DAO supplements to help the body break down histamine or take anti-histamines to control levels of histamine in the blood.38

MCAS and Autism Spectrum Disorder

Over the past decade, a number of reports and studies have linked Autism Spectrum Disorder (ASD) with immune dysregulation and chronic inflammation in the body, including in the brain.39 40 41

There is evidence that mast cell dysregulation is associated with Autism Spectrum Disorder (ASD).42 43

Some researchers have suggested that the relationship between immune response and brain function may be negatively affected when toxins cross the blood brain barrier during a critical point in neural development, causing neurotoxicity and immune dysregulation that disrupts the natural neuron pruning process and contributes to the development of autism spectrum disorders. 44

If the immune system is dysregulated, it can affect the formation and necessary removal of physical connections between neurons that is critical to maintaining healthy brain cell function.45

ASD children have a higher rate of allergies (30%) compared to neurotypical children (2.5%).

Tufts University Professor Theodore Theoharides, PhD, MD, who has conducted extensive research into mast cell disorders, has published a series of studies on the association between MCAS and autism. The evidence he has provided suggests that overactive mast cells in the brain and gut triggered by non-allergic stimulus can lead to brain inflammation and chronic brain dysfunction with symptoms diagnosed as autism.

Evidence that mast cells play a role in ASD is also supported by the fact that the hypothalamus, which regulates behavior and language, houses the majority of mast cells in the brain and people with ASD often have problems associated with language and behavior.46

What Are Co-Factors for Developing MCAS?

Currently, MCAS is not considered to be a genetically inherited disease but there is evidence for epigenetic predisposition to development of MCAS as it tends to run in families, albeit with varying degrees of severity and presentations in individuals within the same family.47

Perinatal stress, environmental exposures, DNA methylation, somatic genetic mutations and interactions between microbiota and mast cells have been proposed as contributing co-factors.48 49 50

According to University of Minnesota Professor Lawrence Afrin, MD, an oncologist and leading mast cell authority, mast cell disease can present with different manifestations and outcomes for each person because every person is unique:

“Conveying a new understanding that all mast cell disease features inappropriate mast cell activation, the new top level mast cell activation disease (MCAD) encompasses various types of rare mastocytosis and likely prevalent mast cell activation syndrome (MCAS).

The apparent uniqueness in each patient with MCAD of constitutively activating mutational patterns in KIT and other mast cell regulatory elements likely is the principal driver of not only the specific clinical presentation, and therapeutic response profile, in each patient but also the great heterogeneity across this population.”51

Inflammation and Vaccination

When the immune system repeatedly mounts an inappropriate acute inflammatory response to antigens or non-allergic substances, it can lead to unwanted chronic inflammation in the body that is common to a number of immune and neuroimmune system disorders.52 53

Vaccination stimulates an inflammatory immune response that promotes production of antibodies and the acquisition of artificial active immunity.54

However, unlike naturally acquired immunity that involves a normal inflammatory response producing both innate (cellular) and humoral (adaptive) immunity, most vaccines manipulate the immune system in way that only stimulates production of vaccine strain antibodies and humoral immunity.55

Because vaccine acquired artificial immunity is temporary, many vaccines contain adjuvants, such as aluminum or squalene, to stimulate a strong inflammatory response in the body, which involves mast cell activation.56

There is mounting scientific evidence that when individuals cannot tolerate hyper-stimulation of the immune system, the atypical inflammatory response to vaccination can remain unresolved, become chronic, and lead to allergy and autoimmunity.57

Vaccines contain many ingredients, including chemicals, virus like protein particles and heavy metals, such as aluminum adjuvants and mercury (Thimerosal) preservatives, as well as other substances that can cause inflammation.58 59

Mercury can activate and destabilize mast cells,60 61 which disrupts the blood brain barrier and makes it easier for mercury to enter the brain where it can remain for long periods of time.62

Even a low concentration of mercury has been shown to activate mast cell mediators in the brain. Scientists have demonstrated that Thimerosal-derived ethylmercury is a mitochondrial toxin and may damage mitochondrial DNA.63

Polysorbate 80 is a chemical emulsifier added to some vaccines. Polysorbate 80 has the ability to help deliver substances across the protective blood brain barrier and into the brain.64

When toxins enter the brain, mast cells are activated and cause inflammation.65

Polysorbate 80 has also been shown to increase histamine levels in animal studies.66

The first vaccine found to cause acute and chronic brain inflammation (acute and chronic encephalopathy) and permanent brain dysfunction was smallpox vaccine created by Edward Jenner in 1796.67

The first vaccine found to cause acute and chronic encephalopathy with permanent brain dysfunction that ranged from learning disabilities and behavior disorders to profound mental retardation was whole cell pertussis vaccine licensed in 1915 and combined in 1949 with diphtheria and tetanus vaccine to create DPT vaccine.68 69

Whole cell pertussis vaccine ingredients include pertussis toxin, endotoxin, aluminum and mercury.70

Cases of pertussis vaccine-related autism were first described in the book DPT: A Shot in the Dark published in 1985.71 72

Is Mast Cell Disease a Risk Factor for Vaccine Reactions?

Mast cells play an important part in keeping the body healthy, but when they malfunction, can cause system wide chronic inflammation in the body that interferes with quality of life or can even cause death.

Dr. Afrin recently related the story of a patient, “who in the first year of his life had been perfectly normal and then, within hours of his first DTP vaccine at age one, developed into just a terrible multi-system inflammatory mess, including essentially acute onset autism.” When he was 20 years old, biopsies tested positive for mast cells. He was subsequently treated for MCAS with remarkable improvement.73

Most babies in the U.S. are being given 25 doses of nine different vaccines (or more) by their first birthday and can receive eight or more vaccines simultaneously.74

As mentioned previously, there are ingredients in vaccines that provoke inflammatory responses in the body that involve mast cell activation.75

Although for the past several decades, most pediatricians and public health officials have rejected the possibility of a relationship between vaccination and the development of allergic and autoimmune disorders,76 the apparent increase in mast cell dysregulation in highly vaccinated populations deserves more in-depth investigation.

The two outstanding questions are:

Does repeated atypical manipulation of the immune system with multiple vaccines in early life trigger MCAS or development of histamine intolerance in genetically or epigenetically predisposed individuals?

Are individuals with undiagnosed MCAS or histamine intolerance at greater risk for suffering vaccine reactions, particularly if they have a personal or family history of allergy or autoimmunity?

There is urgent need for more basic science research into how and why MCAS and histamine intolerance occurs and whether vaccination is a co-factor in increasing individual risks for mast cell dysregulation.

Read the full article at TheVaccineReaction.org.

Comment on this article at VaccineImpact.com.

References:

1 Jennings S, Russell N et al. The Mastocytosis Society Survey on Mast Cell Disorders: Patient Experiences and Perceptions. J Allergy Immunol Pract 2014; 1(1): 70-76. 2 Afrin LB. Mast cell activation and the modern epidemic of chronic inflammatory disease.Translational Research 2016; 174: 33-59. 3 Galli Sj, Tsai M, Piliponsky AM. The development of allergic inflammation. Nature 2008; 454(7203): 445-454. 4 Theoharides TC. Autism Spectrum Disorders and Mastocytosis. Int J Immunopath Pharmacol2009; 22(4): 859-865. 5 Theoharides T, Conti P. Mast cells: the Jekyl and Hyde of tumor growth. Trends in Immunology 2004; 25(5). 6 Zayas E, deSilva M et al. Mast Cell Function: A New Vision of an Old Cell. J Histochem Cytochem 2014; 62(1). 7 Whittemore M, Dileepan K, Wood J. Mast Cell: A Multi-Functional Master Cell. Front Immunol2016; 6:620. 8 University of Rochester Medical Center. White Blood Cells. Health Encyclopedia. 9 Nautiyal KM, Riberio AC et al. Brain mast cells link the immune system to anxiety-like behaviors. Proc Nat Acad Sci 2008; 105(46). 10 Urb M, Sheppard D. The Role of Mast Cells in the Defense Against Pathogens. PLoS Pathog Apr. 26, 2012. 11 Gilfillan S, Austin SJ, Metcalfe DD. Mast Cell Biology: Introduction and Overview. Adv Exp Med Biol 2011; 716: 2-12. 12 Amin K. The Role of Mast Cells in Allergic Inflammation. Respiratory Medicine 2012; 106: 9-14. 13 Encyclopedia Britannica. Inflammation (Pathology). Feb. 28, 2019. 14 Amin K. The Role of Mast Cells in Allergic Inflammation. Respiratory Medicine 2012; 106: 9-14. 15 Metcalfe DD. Mast cells and mastocytosis. Blood 2008; 112(4): 946-956. 16 The Mastocytosis Society. Mast Cell Diseases: Overview, Diagnosis, Definition and Classification. 2018. 17 Molderings GJ, Brettner S et al. Mast Cell Activation Disease: A Concise Practical Guide for Diagnostic Workup and Therapeutic Options. J Hematol Oncol 2011; 4(10). 18 National Institutes of Health. Systemic Mastocytosis. Genetic and Rare Diseases Information Center 2018. 19 Hamilton MJ, Hornick JL et al. Mast cell activation syndrome: A newly recognized disorder with systemic clinical manifestations. J Clin Allergy Immunol 2011; 128(1). 20 Akin C. Mast cell activation syndromes. J Allergy Clin Immunol 2017; 140(2): 349-355. 21 Molderings, GJ, Zienkiewicz T, Risk of solid cancer in patients with mast cell activation syndrome: results from Germany and USA. F1000 Res 2017; 6: 1889. 22 Afrin L. Presentation, Diagnosis and Management of Mast Cell Activation Syndrome. Nova Science Publishers 2013. 23 Hoffman B. Mast Cell Activation Syndrome and Histamine: When Your Immune System Runs Rampant. Hoffman Centre for Integrative and Functional Medicine Nov. 8, 2017. 24 Santos AF, Couto-Francisco N et al. A novel human mast cell activation test for peanut allergy.J Allergy Clin Immunol May 3, 2018. 25 Maintz L, Novak N. Histamine and histamine intolerance. Am J Clin Nutr 2007; 85(5): 1185-1196. 26 National Institutes of Health. Systemic Mastocytosis. Genetic and Rare Diseases Information Center 2018. 27 MastCellDisease. Mast Cell Triggers: What Are the Most Common Triggers? Dec. 12, 2017. 28 Molderings GJ, Haenisch B et al. Pharmacologic treatment options for mast cell activation disease. Naunyn-Schmiedeberg's Archive of Pharmacology 2016; 389(7): 671-694. 29 Hyo-Hyuan P, Lee S et al. Flavanoids inhibit histamine release and expression of proinflammatory cytokines in mast cells. Arch Pharmacol Res 2008; 31:1303. 30 Zayas E, deSilva M et al. Mast Cell Function: A New Vision of an Old Cell. J Histochem Cytochem 2014; 62(1): 698-738. 31 Theoharides TC, Tsilioni I et al. Atopic Diseases and Inflammation of the Brain in the Pathogenesis of Autism Spectrum Disorders. Trans Psychiatry 2016; 6(6). 32 Theoharides TC, Konstantinos-Dionysios A et al. Mast Cells and Inflammation. Biochimica Biophysica Acta 2012; 1822(1): 21-33. 33 Conti P, Caraffa AL. Mast cell, pro-inflammatory and anti-inflammatory: Jekyll and Hyde, the story continues. Journal of Biological Regulators and Homeostatic Agents 2017; 31(2): 263-267. 34 Weinstock LB, Brook JB et al. Successful treatment of postural orthostatic tachycardia and mast cell activation syndromes using naltrexone, immunoglobulin and antibiotic treatment. BMJ Case Reports Jan. 11, 2018. 35 Pizano J. The many effects of histamine. Integrative Therapeutics Mar. 1, 2016. 36 Kovacova-Hanuskova E, Buday T et al. Histamine, histamine intoxication and intolerance.Allergologia et Immunopathologia 2015; 43: 498-506. 37 Hoffman B. Is Your Histamine Intolerance Actually Mast Cell Activation Syndrome? Hoffman Centre for Integrative and Functional Medicine Dec. 5, 2017. 38 Manzotti G, Breda D et al. Serum diamine oxidase activity in patients with histamine intolerance. Int J Immunopathol Pharmacol 2016; 29(1): 105-111. 39 Tonhajzerova I, Ondrejka I et al. (2015) Inflammatory Activity in Autism Spectrum Disorder. In: Pokorski M. (eds) Respiratory Health. Advances in Experimental Medicine and Biology2015. 40 Rossignol DA, Frye RE. A review of research trends in physiologic abnormalities in autism spectrum disorders: immune dysregulation, inflammation, oxidative stress, mitochondrial dysfunction and environmental toxicant exposures. Mol Psychiatry 2012; 17(4): 389-401. 41 Theoharides TC, Asadi S, Patel AB. Focal brain inflammation and autism. J Neuroinflamm2013; 10: 46. 42 Theoharides TC, Doyle BS. Autism, Gut-Blood-Brain Barriers and Mast Cells. J Clin Psychopharmacol 2008; 28(5): 479-483. 43 Theoharides TC, Stewart JM et al. Mast cells, brain inflammation and autism. Eur J Pharmacol 2016; 778: 96-102. 44 Jacome MCI, Chacon LMM et al. Peripheral Inflammatory Markers Contributing to Comorbidities in Autism. Behav Sci (Basel) 2016; 6(4). 45 University of Rochester Medical Center. The Brain's Gardeners: Immune Cells “Prune” Connections Between Neurons. Mar. 7, 2016. 46 Theoharides TC. Is a Subtype of Autism an Allergy of the Brain? Clin Thera 2013; 35(5): 584-591. 47 Molderings GJ, Haenisch B et al. Familial Occurrence of Systemic Mast Cell Activation Disease. PLOS One Sept. 13, 2013 48 Monticelli S, Leoni C. Epigenetic and transcriptional control of mast cell responses. F1000 Research Nov. 29, 2017. 49 U.S. National Library of Medicine. What Is A Gene Mutations and How Do Mutations Occur?July 3, 2018. 50 Afrin LB, Khouruts A. Mast Cell Activation Disease and Microbiotic Interactions. Clin Thera2015; 37(5)): 941-953. 51 Ibid. 52 Walker ME, Hatfield JK, Brown MA. New insights into the role of mast cells in autoimmunity: Evidence for a common mechanism of action? Biochimica et Biophysica Acta 2012; 1822(1): 57-65. 53 Gibney SM, Drexhage HA. Evidence for a Dysregulated Immune System in the Etiology of Psychiatric Disorders. J Neuroimmune Pharmacol 2013; 8(4): 900-920. 54 Ghaffar A. Immunization. University of South Carolina School of Medicine. Nov. 8, 2017. 55 Rydyznski CE, Waggoner SN. Boosting vaccine efficacy the natural (killer) way. Trends Immunol 2015; 36(9): 536-548. 56 deVeer M. New Development in Vaccine Research – Unveiling the Secret of Vaccine Adjuvants. Discovery Medicine Sept. 15, 2011. 57 Vera-Lastra, Medina G et al. Autoimmune/inflammatory syndrome induced by adjuvants (Shoenfeld's syndrome): clinical and immunological spectrum. Expert Review Clinical Immunology 2013; 9(4): 361-373. 58 Fisher BL. Are Vaccine Ingredients Safe? NVIC Jan. 26, 2018. 59 Singh B. Vaccine Ingredient Toxicity – Unraveling the Intiation of Oxidative Damage to Myelin and Role of Mast Cells, Microglia and Schwan Cells in Neurogenic Inflammation and Inhibition of Remyelination. Research Gate Feb. 10, 2017. 60 Kempuraj D, Asadi S et al. Mercury induces inflammatory mediator release from mast cells.Journal of Neuroinflammation 2010; 7:20. 61 Bent S, Gottsch C et al. The effects of heavy metal ions (CD2+, Hg2+, Pb2+, Bi3+) on histamine release from human adenoidal and cutaneous mast cells. Agents and Actions 1992; 36 (Suppl 2). 62 Cariccio VL, Sama A et al. Mercury Involvement in Neuronal Damage and Neurodegenerative Diseases. Biol Trace Element Res May 18, 2018. 63 Sharpe AM, Livingston AD et al. Thimerosal-Derived Ethylmercury is a Mitochondrial Toxin in Human Astrocytes: Possible Role in Fenton Chemistry in the Oxidation and Breakage of mtDNA. J Toxicol June 16, 2012. 64 Koffie RM, Farrar CT et al. Nanoparticles enhance brain delivery of blood-brain barrier-impermeable probes for in vivo optical and magnetic resonance imaging. Proc Natl Acad Sci2011; 108 (46): 18837-18842. 65 Parpia R. Polysorbate 80: A Risky Vaccine Ingredient. The Vaccine Reaction Jan. 7, 2016. 66 Masini E, Planchenault J et al. Histamine releasing properties of Polysorbate 80 in vitro and in vivo: correlation with its hypotensive action in the dog. Agents Action 1985; 16(6): 470-477. 67 Miravelle A, Roos KL. Encephalitis Complicating Smallpox Vaccination. JAMA Neurology2003; 60(7): 925-928. 68 Institute of Medicine Vaccine Safety Committee. Adverse Effects of Pertussis and Rubella Vaccines. Chapter 4: Encephalopathy (pp. 86-88). Washington, DC. The National Academies Press 1991. 69 Institute of Medicine Committee to Study New Research on Vaccines. DPT Vaccine and Chronic Nervous System Dysfunction: A New Analysis. Executive Summary (pp.1-2) Washington, D.C. The National Academies Press 1994. 70 WHO. Recommendations for whole cell pertussis vaccine. WHO Technical Report Series No. 941 2007. 71 Coulter HL, Fisher BL. DPT: A Shot in the Dark. Harcourt Brace Jovanovich 1985. 72 Fisher BL. Vaccines, Autism and Chronic Inflammation: The New Epidemic. The Autism File2009. 73 Ruscio M. Mast Cell Activation Part 2 with Dr. Lawrence Afrin. April 2018. 74 CDC. Recommended Immunization Schedule for Children and Adolescents Aged 18 Years or Younger, United States, 2018. Feb. 6, 2017. 75 CDC. Vaccine Excipient & Media Summary. March 2018. 76 Offit PA, Hackett CJ. Addressing Parents' Concerns: Do Vaccines Cause Allergy or Autoimmune Diseases? Pediatrics 2003; 111(3).

Leaving a lucrative career as a nephrologist (kidney doctor), Dr. Suzanne Humphries is now free to actually help cure people. In this autobiography she explains why good doctors are constrained within the current corrupt medical system from practicing real, ethical medicine. FREE Shipping Available! Order here.

Medical Doctors Opposed to Forced Vaccinations – Should Their Views be Silenced?

eBook – Available for immediate download.

One of the biggest myths being propagated in the compliant mainstream media today is that doctors are either pro-vaccine or anti-vaccine, and that the anti-vaccine doctors are all “quacks.”

However, nothing could be further from the truth in the vaccine debate. Doctors are not unified at all on their positions regarding “the science” of vaccines, nor are they unified in the position of removing informed consent to a medical procedure like vaccines.

The two most extreme positions are those doctors who are 100% against vaccines and do not administer them at all, and those doctors that believe that ALL vaccines are safe and effective for ALL people, ALL the time, by force if necessary.

Very few doctors fall into either of these two extremist positions, and yet it is the extreme pro-vaccine position that is presented by the U.S. Government and mainstream media as being the dominant position of the medical field.

In between these two extreme views, however, is where the vast majority of doctors practicing today would probably categorize their position. Many doctors who consider themselves “pro-vaccine,” for example, do not believe that every single vaccine is appropriate for every single individual.

Many doctors recommend a “delayed” vaccine schedule for some patients, and not always the recommended one-size-fits-all CDC childhood schedule. Other doctors choose to recommend vaccines based on the actual science and merit of each vaccine, recommending some, while determining that others are not worth the risk for children, such as the suspect seasonal flu shot.

These doctors who do not hold extreme positions would be opposed to government-mandated vaccinations and the removal of all parental exemptions.

In this eBook, I am going to summarize the many doctors today who do not take the most extremist pro-vaccine position, which is probably not held by very many doctors at all, in spite of what the pharmaceutical industry, the federal government, and the mainstream media would like the public to believe.

Read:

Medical Doctors Opposed to Forced Vaccinations – Should Their Views be Silenced?

on your mobile device!

$0.99

Dr. Andrew Moulden: Every Vaccine Produces Harm

eBook – Available for immediate download.

Canadian physician Dr. Andrew Moulden provided clear scientific evidence to prove that every dose of vaccine given to a child or an adult produces harm. The truth that he uncovered was rejected by the conventional medical system and the pharmaceutical industry. Nevertheless, his warning and his message to America remains as a solid legacy of the man who stood up against big pharma and their program to vaccinate every person on the Earth.

Dr. Moulden died unexpectedly in November of 2013 at age 49.

Because of the strong opposition from big pharma concerning Dr. Moulden's research, we became concerned that the name of this brilliant researcher and his life's work had nearly been deleted from the internet. His reputation was being disparaged, and his message of warning and hope was being distorted and buried without a tombstone. This book summarizes his teaching and is a must-read for everyone who wants to learn the “other-side” of the vaccine debate that the mainstream media routinely censors.

Read:

Read Dr. Andrew Moulden: Every Vaccine Produces Harm on your mobile device!

on your mobile device!

$3.99

Say NO to Mandatory Vaccines T-Shirt

100% Pre-shrunk Cotton Order here!

Make a Statement for Health Freedom!

Big Pharma and government health authorities are trying to pass laws mandating vaccines for all children, and even adults.

Show your opposition to forced vaccinations and support the cause of Vaccine Impact, part of the Health Impact News network.

Order here!

0 notes

lopezdorothy70-blog · 6 years ago

Text

Are Vaccines Linked to Increase in Mast Cell Disease and Allergies?