#Genomic research

[familythings]

A Glimpse into the Future: Preserving Humanity's DNA in 5D Crystals

Imagine a world where humanity’s DNA is safely stored, ready to be accessed billions of years from now. A team of British scientists from the University of Southampton is making this vision a reality. They have successfully encoded the entire human genome into a remarkable 5D crystal, potentially offering a lifeline for humanity if it ever faces extinction. The Science Behind the Crystal Led by…

[catboybiologist]

You're being targeted by the CIA on Twitter

Oh MOTHERFUCKER LMAO

Where's the option for "both, and still do"

[bobcat-pie]

HOWM'ST THE FUCCCCCK DID IT TAKE ME THIS LONG TO LEARN ABOUT THE TEXAS BLIND SALAMANDER

I HAVE BEEN OBSESSED WITH OLMS FOR YEARS KNOWING THAT I'LL PROBABLY NEVER SEE ONE SINCE I DON'T HAVE THE WILL TO TRAVEL TO SLOVENIA. BUT THERE'S AMERICAN VERSIONS OF OLMS PRODUCED BY CONVERGENT EVOLUTION.

WHAT A WORLD!!!

WHAT A BEAUTIFUL WORLD!!!!!!!

[petervintonjr]

Meet the unsung contributor to revolutionary breakthroughs in treating polio, cancer, HPV, and even COVID-19: Henrietta Lacks. Born in 1920 Roanoke, Virginia, Henrietta's mother Eliza died when she was only four, and she was ultimately raised by her maternal grandfather in Clover, Virginia. Henrietta worked as a tobacco farmer and attended a segregated school until the age of 14, when she gave birth to a son, Lawrence. A daughter, Elsie, was born three years later --to compound the family's difficulties, Elsie had cerebral palsy and epilepsy. Henrietta and her now-husband David Lacks moved to Turner Station (now Dundalk), Maryland where David had landed a job with a nearby steel plant. At the time Turner Station was one of the oldest African-American communities in Baltimore County and there was sufficient community support for the family to buy a house and produce three more children.

In 1951 at the age of 31, Henrietta died at Johns Hopkins Hospital of cervical cancer, mere months after the birth of the family's youngest son. But before her death --and without her or her family's consent-- during a biopsy two tumour cell samples were taken from Henrietta's cervix and sent to Johns Hopkins researchers. Hernietta's cells carried a unique trait: an ability to rapidly multiply, producing a new generation every 24 hours; a breakthrough that no other human cell had achieved. Prior to this discovery, only cells that had been transformed by viruses or genetic mutations carried such a characteristic. With the prospect of now being able to work with what amounted to the first-ever naturally-occurring immortal human cells, researchers created a patent on the HeLa cell line but hid the donor's true identity under a fake name: Helen Lane.

It is no exaggeration to state that in the 70 years since her death, Henrietta's cells have been bought, sold, packaged, and shipped by thousands of laboratories; with her cells being used as a baseline in as many as 74,000 different studies (including some Nobel Prize winners). Her cells have even been sent into space to study the effects of microgravity, and were instrumental in the Human Genome Project. While no actual law (or even a code of ethics) necessarily required doctors to ask permission before taking tissue from a terminal patient, there was a very clear Maryland state law on the books that forbade tissue removal from the dead without permission, throwing the situation into something of a legal grey area. However because Henrietta was poor, minimally educated, and Black, this standard was quietly (and easily) circumvented and she was never recognized for her monumental contributions to science and medicine ...and her family was never compensated. The family remained unaware of Henrietta's contribution until 1975, when the HeLa line's provenance finally became public. Henrietta had been buried in an unmarked grave in the family cemetery in Clover, Virginia but in 2010 a new headstone was donated and dedicated, acknowledging her phenomenal contribution. That same year the John Hopkins Institute for Clinical and Translational Research established a new Henrietta Lacks Memorial lecture series. A statue of Lacks was commissioned in 2022, to be erected in Lacks's birthplace of Roanoke, Virginia --pointedly replacing a previous statue of Confederate Gen. Robert E. Lee, which had been removed following nationwide protests over the murder of George Floyd.

Dive into The Immortal Life of Henrietta Lacks by Rebecca Skloot, originally published in 2011 and subsequently adapted into an HBO movie in 2017, starring Oprah Winfrey as Henrietta's daughter Deborah and Renee Elise Goldberry as Henrietta. (And yes, this book has been challenged and banned in more than one school district.)

[cbirt]

Large Language Models (LLMs) have emerged as dynamic tools with the ability to transform the landscape of biological research in a world driven by data and technology. These advanced AI models, including well-known names like BERT and GPT, are not confined to linguistics but have found their way into the complex realm of biology. In this article, let’s explore the potential of LLMs in addressing pressing biological challenges, such as drug discovery, disease diagnosis, genomics, and more.

What are Large Language Models?

ChatGPT, along with similar models, has gained widespread attention and adoption. Many people even integrate it into their daily routines. What makes ChatGPT and similar models remarkable? These LLMs represent a facet of artificial intelligence (AI) specifically formulated to understand, process, and even create “human-like” text. Developers construct them using transformers—a type of neural network—as their architecture; they pre-train these on copious amounts of textual data to assimilate the patterns, structures, and nuances inherent in human language.

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[inheritance-beyond-genes]

07.06.24

Analog desk > everything

[thepastisalreadywritten]

[ladysqueakinpip]

the only thing my sister and i have to offer to the rise fandom is theories about how lou jitsu's dna recombined with the turtles

[cellbiologist]

Molecular Biology

"Molecular biologists unravel the complexities of life at the most fundamental level, studying the structure and function of molecules that make up cells. Their work advances our understanding of genetics, protein interactions, and cellular processes, driving breakthroughs in medicine, biotechnology, and environmental science. Through cutting-edge research, molecular biologists are at the forefront of discovering the molecular mechanisms that govern life, contributing to innovations that shape the future of science and healthcare."

[covenawhite66]

This species has unique sets of microchromosomes. The genome alters itself when microchromosomes are lost when a creature ages and develops but the microchromosomes only remain in the reproductive organs.

This evolved in vertebrates being able to clone their genome in reproduction and to turn off certain genes in cells.

This creature is the origin of the complex brain, sensory organs the jaw, the limbs, and a greater number of switches that turn genes on/off.

This paper is on Hagfish phylogenomics and gene family evolution being the origin of WGD or a sister group of vertebrates to the first to have multiple sets of chromosomes.

Whole-genome duplication (WGD) evolved in vertebrates during the late Cambrian and early Ordovician periods.

We calculated the likelihood of gene duplication and loss patterns under the competing R1 and R2 hypotheses.

[religion-is-a-mental-illness]

By: Colin Wright

Published: May 26, 2024

It is completely inexcusable that there are no representatives who acknowledge biological sex as binary and immutable at this symposium.

One month ago, I was alerted about an upcoming symposium on sex and gender organized by the National Human Genome Research Institute (NHGRI), an institute of the National Institutes of Health (NIH), in a thread on X by trans rights activist and biologist Jey McCreight.

McCreight was responding to a series of posts by JK Rowling, who offered £1,000,000 pounds to any woman who could prove she had Klinefelter syndrome. A trans-identified male X user named Taylor came forward claiming to be “a chick with Mosaic Klinefelter syndrome,” and asked when he would be paid. Rowling responded, “The cheque will be written the moment I see proof of no Y chromosome!” To my knowledge, Taylor has not yet provided such proof.

McCreight weighed in, proudly touting her credentials: “JK Rowling is not an expert in genetics. But I am!” She then made pseudoscientific assertions about “chromosomal sex” while ironically accusing Rowling and her supporters of having a “5th grade understanding of biology.”

The following day, McCreight shared a screenshot of a message she received from the National Human Genome Research Institute (NHGRI). The message thanked her for tagging them in her post and informed her about “a two-day symposium in July that will bring together experts from the biological and social sciences to clarify (not resolve!) the complexity of sex categorization.”

Registration for the symposium, titled “Exploring the many dimensions of sex and gender in the genomics era,” opened on May 19, and the “tentative agenda” was revealed.

However, despite the event's stated purpose of bringing “experts from the biological and social sciences to clarify and contextualize – but not resolve – the complexities around sex, gender, and genomics by considering them in their scientific, ethical, and historical contexts,” the list of presenters is ideologically homogeneous, consisting entirely of activist scientists and radical gender ideologues.

Here’s the agenda:

Who are these people? Let’s take a look:

One of the speakers is Julia Serano, a self-described activist who writes about sex on her blog. Serano believes that sex is “a collection of sexually dimorphic traits" that, with the exception of chromosomes, can be changed with hormones and surgery to literally change a person’s sex. She has described the claim that “trans women are biological males” as “a myth.”

Another presenter, Beans Velocci, stated in a recent article in Cell, that “sex is an incoherent category, one that has perhaps outlived its use.” Velocci says that belief in the reality of sex categories “fuels ongoing arguments about the purportedly biological reasons that transgender (and especially nonbinary) people are not deserving of rights or do not even exist.”

And what would a symposium about sex be without Anne Fausto-Sterling? She will also be in attendance. Fusto-Sterling is responsible for the pseudoscientific assertion that there are “5 sexes” and the originator of the widely debunked 1.7% statistic for so-called “intersex” conditions. She believes biological sex is a multi-level/variate spectrum. Or a social construct. Or both. Or neither. It’s unclear.

Patrick Grzanka, an associate professor of psychology and chair of the Women, Gender & Sexuality Interdisciplinary Program at the University of Tennessee, Knoxville, will also be present. You might remember Grzankafrom Matt Walsh’s documentary, “What Is a Woman?” He was the guy who refused to say that a “trans woman” is a “male” and stated that “invoking the the word ‘truth’” was “condescending and rude.”

Then there’s Catherine Clune-Taylor, an Assistant Professor of Gender and Sexuality Studies at Princeton. Her dissertation is titled “From Intersex to DSD: A Foucauldian Analysis of the Science, Ethics and Politics of the Medical Production of Cisgendered Lives.” In a book chapter for The Routledge Handbook of Feminist Philosophy of Science titled “Is Sex Socially Constructed?”, Clune-Taylor argues that “our understanding of biological sex and its multiple material components – is shaped by socio-culturally and temporally specific meanings, and material arrangements.” She also contends that what we typically refer to as “sex differences” are “better characterized as material effects of development within a gendered environment than evidence of naturally binary sex.”

Melissa Wilson, an evolutionary and computational biologist at Arizona State, does not necessarily fit the typical activist profile. However, based on her posts on X, she appears to believe that sex is a non-binary “spectrum.”

Sam Sharpe, a PhD candidate at Kansas State University, self-describes as “a trans and intersex person” who has “been involved in trans and intersex activism since 2016.” Sharpe calls for a “more inclusive understanding of sex diversity” and believes Lia Thomas is being discriminated against for “failing to conform to expectations of cisnormative white femininity.” Sharpe says that “biological sex is complex, variable, not fully understood, and definitely not a binary,” and blames the binary view of sex on “capitalism.”

Cassius Adair, who is moderating a session, has a PhD in English from the University of Michigan. According to his website, he provides “queer and trans storytelling consulting for popular podcasts and public radio programs” and serves as a “transgender sensitivity reader.”

Paisley Currah, a professor of political science and women’s and gender studies at Brooklyn College, is also an author and trans rights activist. He published a book in 2022 titled Sex Is as Sex Does, which argues against sex classification laws.

Ross Brooks, another presenter, is a historian focusing on the “queer history of science.” He served as a contributing editor for a queer-themed edition of Viewpoint: The Magazine of the British Society for the History of Science, with the goal of “Queering the Museum.”

Christopher Donohue is a historian of science at the National Human Genome Research Institute. His research “uses the history and present manifestations of eugenics, scientific racism, ableism, heteronormativity and their complex connections to contemporary genomics and medicine to facilitate meaningful and difficult conversations that promote equity and confront past and present wrongs.” His specific views on the biology of sex are unclear, but the activist language saturating his work is indicative.

Os Keys is a PhD candidate at the University of Washington, and describes himself as a “genderfucky nightmare goth.” An LGBTQ+ activist, Keys has blocked me on X, although we have never interacted.

Liz Dietz works at the NIH and researches “bioethics as it pertains to disability rights and LGBTQ issues” designed to “let us reckon with the past.” It is unclear what her views on the biology of sex are, but the activist language in her research is suggestive.

Kellan Baker, a health services researcher at the Whitman-Walker Institute, identifies as a trans man and LGBTQ+ activist. Baker claims to “have been every letter in the LGBTQ acronym.” Baker’s research focuses on “data equity,” and Baker has argued against binary sex classification forms.

Isabel Goldman is a trans-identifying male and an inclusion and diversity officer at Cell Press. Goldman has approvingly shared the quote “Science’s rigid commitment to binary sex and gender quashes creativity and limits progress.” Goldman has also claimed that “the categorization of people into binary, immutable sexes at birth is as much of a social construct as gender is.”

Lastly, Nikki Stevens (they/them), is a postdoctoral researcher at MIT writing a book about “abolition(ist) tech and white supremacy.” Stevens works in a “Data + Feminism Lab” that studies “data activism practices of trans-led groups in the United States.” Stevens has given talks titled “Breaking the Binary.”

That’s everyone.

One thing is clear: this is not a serious symposium concerned with truth and deepening our understanding of sex and gender in genomics—it’s a gender activism strategy session. It is completely inexcusable that there are no representatives who acknowledge biological sex as binary and immutable at this symposium. It is imperative that the NHGRI extend an invitation to individuals like Carole Hooven, Emma Hilton, Heather Heying, Jerry Coyne, Richard Dawkins, or myself, who can offer a different, and scientifically accurate, perspective.

The NHGRI must immediately rectify their error.

==

This is like a conference of Flat Earthers, homeopathy, alien abductionists and Bigfoot hunters.

Note: "Jey" McCreight is Jen McCreight, who organized "Boobquake," a rally which came in reaction to nonsensical Islamic pseudoscience.

https://en.wikipedia.org/wiki/Boobquake#Inception

The Boobquake rally served to protest news reports of controversial beliefs espoused by Hojatoleslam Kazem Seddiqi, an Islamic religious authority in Iran. Seddiqi blamed women who dress immodestly for causing earthquakes. On April 19, 2010, it was reported that Seddiqi advised his listeners that "Many women who do not dress modestly lead young men astray, corrupt their chastity and spread adultery in society, which increases earthquakes" and Iranians should "adapt their lives to Islam's moral codes" to avoid being "buried under the rubble".

She subsequently cut off her boobs and claims she's a "he/they."

"Science in progress." 🤡🤡🤡

[opens-up-4-nobody]

...

[impactofhealth]

Health Research & News: Navigating the Sea of Information

Staying informed about health research and news is crucial for making informed decisions about our well-being. With the abundance of information available, it’s essential to navigate through the sea of data and distinguish between reliable sources and misinformation. Let’s delve into the world of health research and news, exploring its significance, challenges, and impact on society. Read More...

[cbirt]

Cancer, a complex disease arising from genetic alterations, has been a major global health challenge. Researchers have been able to make considerable progress in their understanding; however, the poor availability of real-world data on the cancer genome has limited the progress. To overcome this loss, a group of researchers at the Ontario Institute of Cancer Research and the University of Toronto led by Ander Díaz-Navarro and Lincoln Stein devised a new methodology to create synthetic cancer genomes by means of generative AI.

This method, OncoGAN, extends chances to cancer researchers by offering ample and various types of realistic synthetic cancer genomes. Because of the unencumbered data privacy restrictions, OncoGAN provides opportunities for researchers to create and improve methods that will result in better cancer diagnostics, prognostics, and treatments.

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