#Efficiency in Pharma

[vastedge330]

Discover how Microsoft Dynamics 365 Business Central can transform the pharmaceutical industry with its powerful features. This blog post outlines seven significant benefits of adopting this all-in-one business management solution. From streamlining operations and enhancing regulatory compliance to improving financial management and enabling better decision-making, learn how Business Central can address industry-specific challenges and drive growth in the pharma sector.

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[blog-kmsantosh-me-blog]

Pharma Shipping: Ensuring Safe and Efficient Transport of Medicines 

In the global pharmaceutical industry, the transportation of medicines is a critical aspect that requires meticulous attention to detail. From manufacturing plants to distribution centers and ultimately to pharmacies and hospitals, pharmaceutical products undergo a complex journey before reaching the hands of patients. The efficiency and safety of this journey are paramount to ensure the integrity of the medications and, more importantly, the well-being of the patients who rely on them.

Pharmaceutical shipping involves numerous challenges and considerations that are unique to the industry. Unlike shipping durable goods, pharmaceutical products are often temperature-sensitive and require special handling to maintain their efficacy. This is particularly crucial for biologics, vaccines, and other sensitive medications that can degrade if exposed to improper conditions during transit.

Temperature control is perhaps the most critical aspect of pharmaceutical shipping. Many medicines have strict temperature requirements, and deviations from these conditions can render them ineffective or even harmful. To address this challenge, pharmaceutical companies and logistics providers utilize advanced temperature-controlled packaging and monitoring systems. These solutions help maintain the desired temperature range throughout the shipping process, providing real-time data and alerts to mitigate any potential risks.

Furthermore, regulatory compliance adds another layer of complexity to pharmaceutical shipping. Different countries have their own regulations governing the transportation of pharmaceutical products, including requirements for labeling, documentation, and quality assurance. Ensuring compliance with these regulations is essential to avoid delays, fines, and potential damage to the company's reputation.

In recent years, technological advancements have revolutionized the field of pharmaceutical shipping. From blockchain-based supply chain tracking to the use of artificial intelligence for predictive analytics, companies are leveraging innovative solutions to enhance transparency, efficiency, and security in the transportation of medicines. These technologies not only enable real-time monitoring of shipments but also facilitate traceability and accountability throughout the supply chain.

Despite these advancements, challenges remain, particularly in the face of global health crises such as the COVID-19 pandemic. The unprecedented demand for certain medications, coupled with disruptions to transportation networks, has underscored the importance of robust and resilient pharmaceutical shipping systems. In response, stakeholders across the industry are collaborating to develop contingency plans, optimize supply chain logistics, and implement measures to ensure the uninterrupted flow of essential medicines.

In conclusion, pharmaceutical shipping plays a crucial role in ensuring the availability and safety of medications for patients worldwide. By addressing challenges such as temperature control, regulatory compliance, and technological innovation, stakeholders can enhance the efficiency, reliability, and security of pharmaceutical supply chains. Ultimately, these efforts contribute to improving public health outcomes and advancing the mission of the pharmaceutical industry to enhance the quality of life for people everywhere.

[apacnewsnetwork0]

PLI scheme for Pharma, drones and textiles to be modified by govt

New Delhi: The government is planning to make adjustments to the production-linked incentive PLI scheme for pharmaceuticals, drones, and textile sectors. According to an official statement, these modifications are intended to stimulate investment and bolster manufacturing. An official source has stated that these sectors were chosen on the basis of their performance under the existing scheme for various products.

Higher disbursement scheme for PLI scheme

The official said, “Disbursement of production-linked incentives (PLI) for white goods (AC and LED lights) would start this month and that would push the amount of disbursement, which was only Rs 2,900 crore till March 2023.”

After the identification of sectors, a combined note for approval from the Union Cabinet will be sent. The change in disbursement includes an extension of time for Pharma sectors, and addition of products in some sectors. Within the textile industry, there is a proposal to expand the scope of particular products within the technical textiles category, while in the drone sector, there is a plan to raise the incentive amount.

Read More here : https://apacnewsnetwork.com/2023/09/pli-scheme-for-pharma-drones-and-textiles-to-be-modified-by-govt/

[artimaurya]

What is the future of accounting software?

The future of accounting software looks promising and exciting, as technology continues to advance and shape the way businesses operate. With the advent of cloud computing, machine learning, artificial intelligence, and blockchain technology, accounting software is becoming more sophisticated and efficient than ever before.

One of the key trends in the future of accounting software is the move towards automation. Businesses are looking to automate routine accounting tasks, such as data entry, bookkeeping, and invoice processing, to free up time and resources for more strategic activities. This not only improves accuracy but also enables businesses to gain better insights into their financial performance and make more informed decisions.

Another trend is the integration of accounting software with other business systems, such as customer relationship management (CRM), enterprise resource planning (ERP), and supply chain management (SCM) systems. This enables businesses to streamline their operations and gain a holistic view of their business performance.

One of the accounting software solutions that align with this trend is AlignBooks. AlignBooks is a cloud-based accounting software designed for small and medium-sized businesses. It provides a comprehensive suite of features that cover everything from accounting and invoicing to inventory management and payroll processing.

AlignBooks also offers advanced automation features, such as bank reconciliation, recurring transactions, and automatic billing, to help businesses save time and reduce errors. Additionally, the software integrates with other business systems, such as CRM and ERP, to provide a complete view of business performance.

In conclusion, the future of accounting software is exciting and holds a lot of promise for businesses. With the rise of automation, integration, and advanced technology, businesses will be able to streamline their operations, improve accuracy, and gain better insights into their financial performance. AlignBooks is an excellent example of accounting software that aligns with these trends and can help businesses stay ahead of the curve.

[pebblegalaxy]

Mitsubishi Tanabe Pharma leverages UiPath's automation to enhance business operational efficiency

UiPath, a prominent enterprise automation software company listed on the New York Stock Exchange under the ticker symbol PATH, has announced that Mitsubishi Tanabe Pharma Corporation, a leading Japanese pharmaceuticals company, has adopted the UiPath Business Automation Platform to enhance their business operational efficiency beyond human labor capabilities. Mitsubishi Tanabe Pharma is…

[drdessertfox]

It’s been really interesting to see the turn medicine has made with the public over the past several years. I would never advocate that you should trust any physician blindly, but it’s quite amazing that those with GED level education are trying to convince others glucola is evil, the vitamin K shot is unnecessary, and that doctors order certain medicines and tests because “big pharma” pays them to do so.

I want to be very clear- as an EM physician I am paid hourly, much like all other EM physicians. I do have an RVU component meaning I make more money if I am more efficient but that is only a minimal component of my pay. I want to have conversations with my patients and help address your emergencies, but it’s incredibly difficult when I’m met with antagonistic attitudes from the start that stem from misinformation and fear mongering of online crunchy mom influencers.

[shinobicyrus]

One thing my brain keeps going back to about Pacific Rim (besides the rad giant robots) is the whole existence of kaiju organ harvesters and their implications.

Like, you have Hannibal Chau, a bizarre and interesting character, but we’re presented with a black market operation that seems mostly interested in the “alternative medicine” uses of kaiju parts.

But my brain demands to know: what does the corporate kaiju harvesting industry look like? Sure kaiju blood is toxic, but there are plenty of toxic materials that have useful applications. Are there chemical companies studying kaiju organs? Big-Pharma jumping on the kaiju bone-powder bandwagon? Are bio-tech firms studying kaiju hide to make tougher materials? Agribusinesses clamoring to acquire kaiju crap for fertilizer?

I’m picturing something like the age of whaling, when humans hunted giant animals and carved them up to feed insatiable industries. Whale-oil lighting lanterns for entire cities, whale-bone being used in everything from knick-knacks, tools, umbrellas, and corsets. Ambergris alone was used in perfumes, medicines, cooking. It was even added to wine as an aphrodisiac.

We glimpsed how kaiju affected pop-culture. Now picture a kaiju smashing a city, but the stock market going up for construction companies (rebuilding the cities), vulture real estate (buying the destroyed land cheap), and all the other corporations that profit from the systematic dismantling of a kaiju corpse and making money off of its parts. Sure, a city was roughed up and who knows how many thousands are dead, but it’s a better windfall when a kaiju makes landfall. It’s always less profitable when jaegers kill them too quickly; sea-based extractions are so much more expensive.

Imagine entire industries, entire economies that don’t just make money from the devastation of kaiju attacks, but grow dependent on them. And then the laws, the squabbles over those valuable, resource-rich kaiju corpses. If a kaiju attacks one country but keeps rampaging and is killed in the country next door, who has claim over the body? The party who was damaged more by it or the country where the corpse physically is? Bidding wars over “cleanup” contracts that cut corners and are only interested in collecting those sweet, sweet, kaiju parts as fast as possible, even if their official mandate is supposed to be the safe removal and cleanup of a toxic substance.

Once jaegers started getting efficient at killing kaiju, the people with all the money became less interested in solving the problem of kaiju attacks and switched to merely managing the industries that kaiju-killing feeds.

What? You want to put more resources into R&D to try and close the Breach? Whatever for? The kaiju comes out, jaegers kill it, and the “host country” gets the proceeds from the kaiju’s body. It’s a win-win for everyone. Why waste time, money, and effort solving a problem that isn’t a problem anymore?

Everything is under control.

[mostlysignssomeportents]

The FTC has Big Pharma’s number

On November 27, I'm appearing at the Toronto Metro Reference Library with Facebook whistleblower Frances Haugen.

On November 29, I'm at NYC's Strand Books with my novel The Lost Cause, a solarpunk tale of hope and danger that Rebecca Solnit called "completely delightful."

The most consistent bright spot in the dark swirl of US politics is the competence of the Biden Administration's progressive enforcers: people like Rohit Chopra, Jonathan Kanter and Lina Khan, who keep demonstrating just how far a good administrator can go. Anyone can have a vision, but knowing how to execute is the difference between hot air and real change:

https://pluralistic.net/2023/10/23/getting-stuff-done/#praxis

Take a minute to contrast Biden's administrators with Trump's: Trump's administrators had an ideological vision just as surely as Biden's do, and Trump himself had a much more pronounced and explicit ideology than Biden, whose governance style is much more about balancing the Democratic Party's blocs than bringing about a specific set of policies:

https://pluralistic.net/2023/03/06/personnel-are-policy/#janice-eberly

But whatever clarity of vision the Trump administration brought to DC was completely undermined by its incompetence (thankfully!). Apart from one gigantic tax break, Trump couldn't get stuff done. He couldn't deliver, because he'd lose his temper or speak out of turn:

https://pluralistic.net/2023/11/14/when-youve-lost-the-fedsoc/#anti-buster-buster

And his administrators followed his lead. Scott Pruitt was appointed to run the EPA after a career spent suing the agency. It could have been the realization of his life's dream to dismantle environmental law in America and open the floodgates for unlimited, wildly profitable corporate pollution and pillaging. But the dream died because he kept getting embroiled in absurd scandals – like the time he sent his staffers out to drive around all night looking for a good deal on a used mattress:

https://www.nbcnews.com/politics/politics-news/epa-s-pruitt-told-aide-obtain-old-mattress-trump-hotel-n879836

Or his insistence on installing a CIA-style "Sensitive Compartmented Information Facility" (SCIF) so he could play super-spy while reading memos:

https://www.cnn.com/2018/04/26/politics/epa-administrator-scott-pruitt-sound-proof-booth-scif/index.html

Or the time he sent his security detail to the Ritz-Carlton to demand that they supply him lots of little bottles of his favorite hand-cream:

https://www.vox.com/2018/6/7/17439044/scott-pruitt-ritz-carlton-moisturizing-lotion

There were other examples in the Trump administration, but Priutt is such a good case-study. He's like a guy who spent his whole life training to compete in the Olympics, and finally got a shot, only to be disqualified for ordering too much room-service in the Olympic Village. Priutt was wildly ambitious, but he was profoundly undisciplined – and wildly incompetent.

Compare that with Biden's progressive enforcers and agency heads, who showed up on the first day of work with an encyclopedic knowledge of their administrative powers, and detailed plans for using them to transform the lives of the American people for the better:

https://pluralistic.net/2022/10/18/administrative-competence/#i-know-stuff

The Biden administration's competence translates into action, getting stuff done. Maybe that shouldn't surprise us, given the difference between the stories that reactionaries and progressives tell about where change comes from.

In reactionary science fiction, we enter the realm of the "Competent Man" story. Think of a Heinlein hero, who is "able to change a diaper, plan an invasion, butcher a hog, conn a ship, design a building, write a sonnet, balance accounts, build a wall, set a bone, comfort the dying, take orders, give orders, cooperate, act alone, solve equations, analyse a new problem, pitch manure, program a computer, cook a tasty meal, fight efficiently, die gallantly."

In Competent Man stories, a unitary hero steps into the breach and solves the problem – if not single-handedly, then as the leader of others, whose lesser competence is a base metal that the Competent Man hammers into a tempered blade:

https://tvtropes.org/pmwiki/pmwiki.php/Creator/RobertAHeinlein

Contrast this with a progressive tale, like, say, Kim Stanley Robinson's Ministry For the Future, where the Competent Man is replaced by the Competent Administration, in which people of goodwill and technical competence figure out how to join forces to create population-scale architectures of participation that allow every person to contribute their skills and perspective:

https://pluralistic.net/2020/12/03/ministry-for-the-future/#ksr

The right's whole ideology insists that the world can only be saved by Competent Men. As Corey Robin writes in The Reactionary Mind, the unifying factor that binds together conservative factions from monarchists to racists to Christian Dominionists is the belief that a few of us are born to rule, and the rest to be ruled over:

https://pluralistic.net/2020/05/25/mafia-logic/#mafia-logic

The Reaganite insistence that governments are, by their very nature, incompetent and malign ("The nine most terrifying words in the English language are, 'I’m from the government, and I’m here to help'"), means that conservatives deny the possibility of a Competent Administration.

When conservatives take office and proceed to bungle the most basic elements of administration, they're fulfilling their own campaign narrative, which starts with "We must dismantle the government because it is bad at everything." Conservatives who govern badly prove their own point, which explains a lot about the UK Tory Party's long run of governmental failure and electoral success:

https://apnews.com/article/uk-suella-braverman-fired-cabinet-shuffle-7ea6c89306a427cc70fba75bc386be79

There's a small mercy in the fact that so many of the most ideologically odious and extreme conservative governments are so technically incompetent in governing, and thus accomplish so little of their agendas.

But the inverse – the incredible competence of the best progressive administrators – is nothing short of a delight to witness. Here's the latest example to cross my path: the FTC has intervened in a lawsuit over generic insulin pricing, on an issue that is incredibly technically specific and also fantastically important:

https://www.fiercepharma.com/pharma/ftc-blasts-pharmas-abuse-fda-patent-system-sanofi-mylans-insulin-monopoly-lawsuit

The underlying case is before the FDA, and it concerns the dirty tricks that pharma giant Sanofi used to keep Mylan from making a generic version of Mylan's Lantus insulin after its patent expired.

There's an explicit bargain in patents: inventors can enlist the government to punish their rivals for copying their ideas, but in exchange, the government demands that the inventor has to describe how the invention works in a detailed patent filing, and when the patent expires, 20 years later, rivals can use the patent application as instructions for freely copying and selling the invention. In other words: you get 20 years of exclusive rights in return for facilitating your competitors' copying and selling your invention when the 20 years are up.

Pharma doesn't like this, naturally: not content with 20 years of exclusivity, they want the government to step in and punish their competitors forever. In service to that end, pharma companies have perfected a process called evergreening, where they dribble out ancillary patents after their initial filing, covering minor reformulations, delivery systems, or new uses.

Evergreening got a moment in the public eye earlier this year, with John Green's viral campaign to shame Johnson & Johnson out of using evergreening to restrict poor countries' access to TB medication:

https://armandalegshow.com/episode/john-green-part-1/

The story of pharma is that it commands gigantic profits, but it invests those profits into medicines that save our lives. The reality is that most of the key underlying pharma research is publicly funded (by Competent Administrators who apportion funding to promising scientific inquiry). Pharma companies' most inventive genius is devoted to inventing new evergreening tactics:

https://pluralistic.net/2023/10/19/solid-tumors/#t-cell-receptors

That's where the FTC comes in, in this Sanofi-Mylan case. To facilitate the production of generic, off-patent drugs, the FDA maintains a database called the "Orange Book," where pharma companies are asked to enumerate all the ancillary patents associated with a product whose patent is expiring. That way, generics manufacturers who make their own version of these public domain drugs and therapeutics don't accidentally stumble over one of those later patents – say, by replicating a delivery system or special coating that is still in patent.

This is where the endless, satanic inventiveness of the pharma sector comes in. You see, US law provides for triple damages for "willful patent infringement." If you are a generics manufacturer eyeing up a drug whose patent is about to expire and you are notified that some other patents might be implicated in your plans, you must ensure that you don't accidentally infringe one of those patents, or face business-destroying statutory damages.

So pharma companies stuff the Orange Book full of irrelevant patent claims they say may be implicated in a generic manufacture program. Each of these claims has to be carefully evaluated, both by a scientific team and a legal team, because patents are deliberately obfuscated in the hopes of tricking an inattentive patent examiner into granting patents for unpatentable "inventions":

https://blueironip.com/patents-that-hide-the-ball/

What's more, when a pharma giant notifies the FDA that it has ancillary patents that are relevant to the Orange Book, this triggers a 30-month delay before a generic can be marketed – adding 2.5 years to the 20 year patent term. That delay is sometimes enough to cause a manufacturer to abandon plans to market a generic drug – so the delay isn't 2.5 years, it's infinite.

This is a highly technical, highly consequential form of evergreening. It's obscure as hell, and requires a deep understanding of patent obfuscation, ancillary patent filings, generic pharma industry practice, and the FDA's administrative procedures.

Sanofi's Orange Book entry for Lantus insulin listed 50 related patent claims. Of these, 48 were invalidated through "inter partes" review (basically the Patent Office decided they shouldn't have allowed these claims to be included on a patent). Neither of the remaining two claims were found to be relevant to the manufacture of generic Lantus.

This is where the FTC's filing comes in: their amicus brief doesn't take a position whether Sanofi's Orange Book entries were fraudulent, but they do ask the FDA to intervene to prevent Orange Book stuffing because "improper listings can cause significant harm to competition and consumers."

This is the kind of boring, technical, important stuff that excellent administrators can do. The FTC's brief is notice to the FDA that it should amend its procedures to ban (and punish) Orange Book abuse. That will make it possible for you, a person who needs medicine, to get that medicine more cheaply and quickly. In America's pay-for-use privatized healthcare hellscape, this could be a life-or-death matter.

There's plenty of things the Biden administration is getting very, very badly wrong, but we shouldn't lose sight of how its progressive wing is making real, lasting change for the better. Competent Administrations are the true peoples' champions. They beat Competent Men every time.

If you'd like an essay-formatted version of this post to read or share, here's a link to it on pluralistic.net, my surveillance-free, ad-free, tracker-free blog:

https://pluralistic.net/2023/11/23/everorangeing/#taste-the-rainbow

[mychlapci]

We need more absolutely deranged merformer aus!

I always sees mers portrayed as “almost as Cybertronians”, in terms of intelligence and acting, but what if yes, mers are indeed smart, but also like, evil little shits… like old folklore fairytales or dolphins. They intelligent but also incredibly aliens and with a totally different cultures, like, they feel love, attraction, know how to use tools, solve riddles and understand basic cybertron… but they also consider cannibalism ok.

They’re also incredibly unpredictable, they might look soft and curious, but in a matter of second they can turn into vicious killing machines that will start eating their prey before they’re drown.

So, Ratchet is somewhat an odd mer, as he’s very easy to handle. He’s kind, curious, and doesn’t show aggressive behaviors. Maybe he used to live in a part od the rust sea where contacts with land mech where at minimum, and he never had bad experiences, or maybe cause he was handled very young, it doesn’t matter. Ratchet is quite the unique specimens and Pharma can’t help himself.

It starts very easy, very innocent, Pharma would test Ratchet, both his intelligence and on a physical level, rewarding him with treats every time he acted right. Soon enough, Ratchet feels comfortable enough to be handled back and forward from his tank to the lab.

Soon, Pharma becomes obsessed with his new pet. It seems like Ratchet would let Pharma do anything to him, accepting even the most painful treatments.

At some point a new mer is introduced into the tank and he and Ratchet are immediately all over each others. If the stats is at first worried to death, they soon realize the two mers are not fighting, but mating. The new mer, someone calls him Drift, for the way he always seems to be Drifting by Ratchet’s side, some others calls him Deadlock, for how vicious he is against the staff’s members, was found hunting close where Ratchet was caught.

Pharma is livid, his Ratchet doesn’t seem interested in their games anymore, only focused on their new guest. But the doctor can’t really say anything about it, as having a living couple in the tank and being able to observe their mating rituals and maybe, even a gestation is something no other lab has been able to do.

Soon enough, Ratchet began showing signs of a possible litter growing inside his belly, and the staff comes out with a plan to release the couple of mer back into their habitats, with a localizer welded on their armor. Pharma is not happy about it, but he’s reassured in the knowledge that he will be able to track Ratchet and takes him back.

The mers are released back into the ocean and quickly disappear in the depth. Pharma keeps track of their location and during off shifts, tries to find them and lure Ratchet out, believing he will be able to attract the mer back.

In reality Ratchet has never been attracted to Pharma. Even among his kind, Ratchet is not a warrior, but a healer. He can defend himself but often prefer to play along, to study his surroundings and buying time for his bigger and way more heavy armored partner, to come to his rescue. Ratchet would often distract their enemies and potential predators, just for Deadlock to lunge in and kill them quickly and efficiently. He acted all sweet and soft with Pharma cause he had to.

But not that Pharma has come in their lair…

auhhh... Forgot about this one.

Ratchet acting docile and soft with Pharma because he's actually scared shitless of his current predicament is so interesting... He knows he can't lash out right now, that he needs to keep his cool and just tough it out until he can figure out a way to solve this. Pharma does not harm him, he's a little condescending, a little presumptuous about the level of Ratchet's intelligence, a bit clingy and overbearing, but he can handle it. Drift finds him quickly enough, and with his personality, most of the facility staff don't really bother messing with Ratchet's tank anymore. Not even Pharma.

Once they're released, Pharma wants his pet mer back. Ratchet was so good, so domesticated, so obedient, he can't be put back in with those savage mers... Pharma would honestly keep him in a tank in his home if he could. He's sure his old buddy Ratchet wouldn't mind :) Of course, he gets quite the surprise when he meets Ratchet back in the wild, his tail fat with pups... The mer is not as responsive as he was before. His wary body language turns aggressive the moment Pharma floats a little too close for comfort. Ratchet and Drift are on top of him in an instant.

And then Pharma gets torn apart and eaten <33 poor guy, but that's what he gets for trying to poach a wild mer!

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[transmutationisms]

what do you think about adhd? such as the rise in drug marketing, medicalization, and globalization

i mean in broad strokes it's basically the same analysis as any other psychiatric diagnostic label lol. people experience an impairment where there's a mismatch between them and what they're socially / academically / professionally expected to be capable of. with adhd specifically the expectations here come largely from employers wanting obedient and efficient workers, and from parents and other authority figures wanting obedient and docile children. because adhd (unlike some dxs) has a very specifically targeted class of drug treatments, a lot of this also gets perpetrated by pharma interests (see: funding conflicts in academic papers, additude mag, &c) trying to encourage more use of their product, which in the current medico-legal arrangement also means pushing for more diagnoses. this is also why there's so much investment in like, studies purporting to find immutable 'brain differences' in adhd-ers and whatnot. talking about this on this site is always instantly rancid and regrettable though because people fear that the only alternative to bio-psychiatry is getting told to suck it up and be crushed in the capitalist machine, so i understand why there's so much investment from patient groups in these types of neuropsychiatric discourses. anyway i personally love to be slightly high on amphetamines and like i always say, it's morally ok to do drugs even if they're prescribed. i like a lot of jesse meadows's writing on adhd btw—they're essentially trying to find ways to talk about and accommodate what's been dx'd as their adhd, without either dismissing the real difficulties they and others experience, or falling back on essentialist psychiatric explanations.

[spiritsofts-training-blog]

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[lord-squiggletits]

Honestly the weirdest thing about all the "forged medic hands" hullabaloo in MTMTE was that Ratchet's hands (and Pharma's original hands that Ratchet stole) are just like. Human hands but made of robotic parts. Why in the fuck are "Swiss army knife hands" like Pharma's Luna-1 replacements not just the literal standard for forged medics?

Isn't it so much more efficient and cooler for robots to have tools built into their hands that they can transform instead of having to go through the extra step of holding tools in their hands? Wouldn't medic hands being able to transform into any tool lend a lot more credence to Functionist ideas of "forged medic hands are the best and if my hands stop working or I get replacements it won't be the same" that Ratchet spouts? Because like at least in that case there would be this interesting robotic worldbuilding in which the space alien robots debate about whether hands-that-hold-tools can be as effective as hands-that-turn-into-tools and the flavor of that would be so cool. And it would create this whole anti-Functionist debate that a pair of hands being "less optimal" doesn't mean that the work they do isn't still worthwhile (for example, just because one doctor has a lower mortality rate than another doctor doesn't mean that both doctors aren't having a positive contribution to the world).

[artimaurya]

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[ikkosu]

Psssst

Ikko

Mean yandere Prowl or Pharma.

They fake being an absolutely perfect boyfriend, but are actually spying on you everywhere, blackmailing your friends, threat your family member, enter in your appartment to steal your clothes/underwears,....

They love you.

So much they could kill anyone.

(Just like the game "Perfect boyfriend Pieter" or smtg this style i don't remember the name)

😈😈😈 how about both ehejejekejej I WANT BOTH EVIL BOYFRIENDS I want them one upping each other in every way lmaooo 😔🙏 ONE CHANCE OUGHHAHHHS 👀 ohh stealing the underwear,,,,,very saucy I like

They would be the most cunning people in existence, though with Prowls explosive anger I think his true personality would shown pretttyyy quickly lmaoo. He's got access to cameras, information about everything. He IS the strategic officer after all and data is something he's very efficient with.

Pharma, though, hes good at keeping up the appearances. Very charming. Less socially awkward, unlike Prowl (less creepy too, I'd imagine prowl would stare at you hours on end LMAO) But very violent ahaha and among the two with the actual BALLS to kill. Prowl? He'd kill, not as often — only when someone is a frequent obstruction, but resorts to confining you in a 'secure' place. (Ahem, isolating, ahem, you) from the rest of the world.

Pharma is a skillful doctor. He knows what to do with those bodies (⁠•⁠‿⁠•⁠)