#Efficiency in Pharma

[vastedge330]

Discover how Microsoft Dynamics 365 Business Central can transform the pharmaceutical industry with its powerful features. This blog post outlines seven significant benefits of adopting this all-in-one business management solution. From streamlining operations and enhancing regulatory compliance to improving financial management and enabling better decision-making, learn how Business Central can address industry-specific challenges and drive growth in the pharma sector.

[yashblower]

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[blog-kmsantosh-me-blog]

Pharma Shipping: Ensuring Safe and Efficient Transport of Medicines 

In the global pharmaceutical industry, the transportation of medicines is a critical aspect that requires meticulous attention to detail. From manufacturing plants to distribution centers and ultimately to pharmacies and hospitals, pharmaceutical products undergo a complex journey before reaching the hands of patients. The efficiency and safety of this journey are paramount to ensure the integrity of the medications and, more importantly, the well-being of the patients who rely on them.

Pharmaceutical shipping involves numerous challenges and considerations that are unique to the industry. Unlike shipping durable goods, pharmaceutical products are often temperature-sensitive and require special handling to maintain their efficacy. This is particularly crucial for biologics, vaccines, and other sensitive medications that can degrade if exposed to improper conditions during transit.

Temperature control is perhaps the most critical aspect of pharmaceutical shipping. Many medicines have strict temperature requirements, and deviations from these conditions can render them ineffective or even harmful. To address this challenge, pharmaceutical companies and logistics providers utilize advanced temperature-controlled packaging and monitoring systems. These solutions help maintain the desired temperature range throughout the shipping process, providing real-time data and alerts to mitigate any potential risks.

Furthermore, regulatory compliance adds another layer of complexity to pharmaceutical shipping. Different countries have their own regulations governing the transportation of pharmaceutical products, including requirements for labeling, documentation, and quality assurance. Ensuring compliance with these regulations is essential to avoid delays, fines, and potential damage to the company's reputation.

In recent years, technological advancements have revolutionized the field of pharmaceutical shipping. From blockchain-based supply chain tracking to the use of artificial intelligence for predictive analytics, companies are leveraging innovative solutions to enhance transparency, efficiency, and security in the transportation of medicines. These technologies not only enable real-time monitoring of shipments but also facilitate traceability and accountability throughout the supply chain.

Despite these advancements, challenges remain, particularly in the face of global health crises such as the COVID-19 pandemic. The unprecedented demand for certain medications, coupled with disruptions to transportation networks, has underscored the importance of robust and resilient pharmaceutical shipping systems. In response, stakeholders across the industry are collaborating to develop contingency plans, optimize supply chain logistics, and implement measures to ensure the uninterrupted flow of essential medicines.

In conclusion, pharmaceutical shipping plays a crucial role in ensuring the availability and safety of medications for patients worldwide. By addressing challenges such as temperature control, regulatory compliance, and technological innovation, stakeholders can enhance the efficiency, reliability, and security of pharmaceutical supply chains. Ultimately, these efforts contribute to improving public health outcomes and advancing the mission of the pharmaceutical industry to enhance the quality of life for people everywhere.

[sigzentechnologies]

ERPNext for Chemical and Pharmaceutical Business: Revolutionizing Industry Efficiency with Sigzen

ERPNext is specifically engineered to meet the complex demands of the chemical and pharmaceutical industries, where precision, compliance, and efficiency are paramount. This ERP system is designed to manage everything from raw material procurement to finished product delivery, ensuring that every step of the manufacturing and distribution processes adheres to strict industry standards and…

[apacnewsnetwork0]

PLI scheme for Pharma, drones and textiles to be modified by govt

New Delhi: The government is planning to make adjustments to the production-linked incentive PLI scheme for pharmaceuticals, drones, and textile sectors. According to an official statement, these modifications are intended to stimulate investment and bolster manufacturing. An official source has stated that these sectors were chosen on the basis of their performance under the existing scheme for various products.

Higher disbursement scheme for PLI scheme

The official said, “Disbursement of production-linked incentives (PLI) for white goods (AC and LED lights) would start this month and that would push the amount of disbursement, which was only Rs 2,900 crore till March 2023.”

After the identification of sectors, a combined note for approval from the Union Cabinet will be sent. The change in disbursement includes an extension of time for Pharma sectors, and addition of products in some sectors. Within the textile industry, there is a proposal to expand the scope of particular products within the technical textiles category, while in the drone sector, there is a plan to raise the incentive amount.

Read More here : https://apacnewsnetwork.com/2023/09/pli-scheme-for-pharma-drones-and-textiles-to-be-modified-by-govt/

[artimaurya]

What is the future of accounting software?

The future of accounting software looks promising and exciting, as technology continues to advance and shape the way businesses operate. With the advent of cloud computing, machine learning, artificial intelligence, and blockchain technology, accounting software is becoming more sophisticated and efficient than ever before.

One of the key trends in the future of accounting software is the move towards automation. Businesses are looking to automate routine accounting tasks, such as data entry, bookkeeping, and invoice processing, to free up time and resources for more strategic activities. This not only improves accuracy but also enables businesses to gain better insights into their financial performance and make more informed decisions.

Another trend is the integration of accounting software with other business systems, such as customer relationship management (CRM), enterprise resource planning (ERP), and supply chain management (SCM) systems. This enables businesses to streamline their operations and gain a holistic view of their business performance.

One of the accounting software solutions that align with this trend is AlignBooks. AlignBooks is a cloud-based accounting software designed for small and medium-sized businesses. It provides a comprehensive suite of features that cover everything from accounting and invoicing to inventory management and payroll processing.

AlignBooks also offers advanced automation features, such as bank reconciliation, recurring transactions, and automatic billing, to help businesses save time and reduce errors. Additionally, the software integrates with other business systems, such as CRM and ERP, to provide a complete view of business performance.

In conclusion, the future of accounting software is exciting and holds a lot of promise for businesses. With the rise of automation, integration, and advanced technology, businesses will be able to streamline their operations, improve accuracy, and gain better insights into their financial performance. AlignBooks is an excellent example of accounting software that aligns with these trends and can help businesses stay ahead of the curve.

[pebblegalaxy]

Mitsubishi Tanabe Pharma leverages UiPath's automation to enhance business operational efficiency

UiPath, a prominent enterprise automation software company listed on the New York Stock Exchange under the ticker symbol PATH, has announced that Mitsubishi Tanabe Pharma Corporation, a leading Japanese pharmaceuticals company, has adopted the UiPath Business Automation Platform to enhance their business operational efficiency beyond human labor capabilities. Mitsubishi Tanabe Pharma is…

[drdessertfox]

It’s been really interesting to see the turn medicine has made with the public over the past several years. I would never advocate that you should trust any physician blindly, but it’s quite amazing that those with GED level education are trying to convince others glucola is evil, the vitamin K shot is unnecessary, and that doctors order certain medicines and tests because “big pharma” pays them to do so.

I want to be very clear- as an EM physician I am paid hourly, much like all other EM physicians. I do have an RVU component meaning I make more money if I am more efficient but that is only a minimal component of my pay. I want to have conversations with my patients and help address your emergencies, but it’s incredibly difficult when I’m met with antagonistic attitudes from the start that stem from misinformation and fear mongering of online crunchy mom influencers.

[mostlysignssomeportents]

The FTC has Big Pharma’s number

On November 27, I'm appearing at the Toronto Metro Reference Library with Facebook whistleblower Frances Haugen.

On November 29, I'm at NYC's Strand Books with my novel The Lost Cause, a solarpunk tale of hope and danger that Rebecca Solnit called "completely delightful."

The most consistent bright spot in the dark swirl of US politics is the competence of the Biden Administration's progressive enforcers: people like Rohit Chopra, Jonathan Kanter and Lina Khan, who keep demonstrating just how far a good administrator can go. Anyone can have a vision, but knowing how to execute is the difference between hot air and real change:

https://pluralistic.net/2023/10/23/getting-stuff-done/#praxis

Take a minute to contrast Biden's administrators with Trump's: Trump's administrators had an ideological vision just as surely as Biden's do, and Trump himself had a much more pronounced and explicit ideology than Biden, whose governance style is much more about balancing the Democratic Party's blocs than bringing about a specific set of policies:

https://pluralistic.net/2023/03/06/personnel-are-policy/#janice-eberly

But whatever clarity of vision the Trump administration brought to DC was completely undermined by its incompetence (thankfully!). Apart from one gigantic tax break, Trump couldn't get stuff done. He couldn't deliver, because he'd lose his temper or speak out of turn:

https://pluralistic.net/2023/11/14/when-youve-lost-the-fedsoc/#anti-buster-buster

And his administrators followed his lead. Scott Pruitt was appointed to run the EPA after a career spent suing the agency. It could have been the realization of his life's dream to dismantle environmental law in America and open the floodgates for unlimited, wildly profitable corporate pollution and pillaging. But the dream died because he kept getting embroiled in absurd scandals – like the time he sent his staffers out to drive around all night looking for a good deal on a used mattress:

https://www.nbcnews.com/politics/politics-news/epa-s-pruitt-told-aide-obtain-old-mattress-trump-hotel-n879836

Or his insistence on installing a CIA-style "Sensitive Compartmented Information Facility" (SCIF) so he could play super-spy while reading memos:

https://www.cnn.com/2018/04/26/politics/epa-administrator-scott-pruitt-sound-proof-booth-scif/index.html

Or the time he sent his security detail to the Ritz-Carlton to demand that they supply him lots of little bottles of his favorite hand-cream:

https://www.vox.com/2018/6/7/17439044/scott-pruitt-ritz-carlton-moisturizing-lotion

There were other examples in the Trump administration, but Priutt is such a good case-study. He's like a guy who spent his whole life training to compete in the Olympics, and finally got a shot, only to be disqualified for ordering too much room-service in the Olympic Village. Priutt was wildly ambitious, but he was profoundly undisciplined – and wildly incompetent.

Compare that with Biden's progressive enforcers and agency heads, who showed up on the first day of work with an encyclopedic knowledge of their administrative powers, and detailed plans for using them to transform the lives of the American people for the better:

https://pluralistic.net/2022/10/18/administrative-competence/#i-know-stuff

The Biden administration's competence translates into action, getting stuff done. Maybe that shouldn't surprise us, given the difference between the stories that reactionaries and progressives tell about where change comes from.

In reactionary science fiction, we enter the realm of the "Competent Man" story. Think of a Heinlein hero, who is "able to change a diaper, plan an invasion, butcher a hog, conn a ship, design a building, write a sonnet, balance accounts, build a wall, set a bone, comfort the dying, take orders, give orders, cooperate, act alone, solve equations, analyse a new problem, pitch manure, program a computer, cook a tasty meal, fight efficiently, die gallantly."

In Competent Man stories, a unitary hero steps into the breach and solves the problem – if not single-handedly, then as the leader of others, whose lesser competence is a base metal that the Competent Man hammers into a tempered blade:

https://tvtropes.org/pmwiki/pmwiki.php/Creator/RobertAHeinlein

Contrast this with a progressive tale, like, say, Kim Stanley Robinson's Ministry For the Future, where the Competent Man is replaced by the Competent Administration, in which people of goodwill and technical competence figure out how to join forces to create population-scale architectures of participation that allow every person to contribute their skills and perspective:

https://pluralistic.net/2020/12/03/ministry-for-the-future/#ksr

The right's whole ideology insists that the world can only be saved by Competent Men. As Corey Robin writes in The Reactionary Mind, the unifying factor that binds together conservative factions from monarchists to racists to Christian Dominionists is the belief that a few of us are born to rule, and the rest to be ruled over:

https://pluralistic.net/2020/05/25/mafia-logic/#mafia-logic

The Reaganite insistence that governments are, by their very nature, incompetent and malign ("The nine most terrifying words in the English language are, 'I’m from the government, and I’m here to help'"), means that conservatives deny the possibility of a Competent Administration.

When conservatives take office and proceed to bungle the most basic elements of administration, they're fulfilling their own campaign narrative, which starts with "We must dismantle the government because it is bad at everything." Conservatives who govern badly prove their own point, which explains a lot about the UK Tory Party's long run of governmental failure and electoral success:

https://apnews.com/article/uk-suella-braverman-fired-cabinet-shuffle-7ea6c89306a427cc70fba75bc386be79

There's a small mercy in the fact that so many of the most ideologically odious and extreme conservative governments are so technically incompetent in governing, and thus accomplish so little of their agendas.

But the inverse – the incredible competence of the best progressive administrators – is nothing short of a delight to witness. Here's the latest example to cross my path: the FTC has intervened in a lawsuit over generic insulin pricing, on an issue that is incredibly technically specific and also fantastically important:

https://www.fiercepharma.com/pharma/ftc-blasts-pharmas-abuse-fda-patent-system-sanofi-mylans-insulin-monopoly-lawsuit

The underlying case is before the FDA, and it concerns the dirty tricks that pharma giant Sanofi used to keep Mylan from making a generic version of Mylan's Lantus insulin after its patent expired.

There's an explicit bargain in patents: inventors can enlist the government to punish their rivals for copying their ideas, but in exchange, the government demands that the inventor has to describe how the invention works in a detailed patent filing, and when the patent expires, 20 years later, rivals can use the patent application as instructions for freely copying and selling the invention. In other words: you get 20 years of exclusive rights in return for facilitating your competitors' copying and selling your invention when the 20 years are up.

Pharma doesn't like this, naturally: not content with 20 years of exclusivity, they want the government to step in and punish their competitors forever. In service to that end, pharma companies have perfected a process called evergreening, where they dribble out ancillary patents after their initial filing, covering minor reformulations, delivery systems, or new uses.

Evergreening got a moment in the public eye earlier this year, with John Green's viral campaign to shame Johnson & Johnson out of using evergreening to restrict poor countries' access to TB medication:

https://armandalegshow.com/episode/john-green-part-1/

The story of pharma is that it commands gigantic profits, but it invests those profits into medicines that save our lives. The reality is that most of the key underlying pharma research is publicly funded (by Competent Administrators who apportion funding to promising scientific inquiry). Pharma companies' most inventive genius is devoted to inventing new evergreening tactics:

https://pluralistic.net/2023/10/19/solid-tumors/#t-cell-receptors

That's where the FTC comes in, in this Sanofi-Mylan case. To facilitate the production of generic, off-patent drugs, the FDA maintains a database called the "Orange Book," where pharma companies are asked to enumerate all the ancillary patents associated with a product whose patent is expiring. That way, generics manufacturers who make their own version of these public domain drugs and therapeutics don't accidentally stumble over one of those later patents – say, by replicating a delivery system or special coating that is still in patent.

This is where the endless, satanic inventiveness of the pharma sector comes in. You see, US law provides for triple damages for "willful patent infringement." If you are a generics manufacturer eyeing up a drug whose patent is about to expire and you are notified that some other patents might be implicated in your plans, you must ensure that you don't accidentally infringe one of those patents, or face business-destroying statutory damages.

So pharma companies stuff the Orange Book full of irrelevant patent claims they say may be implicated in a generic manufacture program. Each of these claims has to be carefully evaluated, both by a scientific team and a legal team, because patents are deliberately obfuscated in the hopes of tricking an inattentive patent examiner into granting patents for unpatentable "inventions":

https://blueironip.com/patents-that-hide-the-ball/

What's more, when a pharma giant notifies the FDA that it has ancillary patents that are relevant to the Orange Book, this triggers a 30-month delay before a generic can be marketed – adding 2.5 years to the 20 year patent term. That delay is sometimes enough to cause a manufacturer to abandon plans to market a generic drug – so the delay isn't 2.5 years, it's infinite.

This is a highly technical, highly consequential form of evergreening. It's obscure as hell, and requires a deep understanding of patent obfuscation, ancillary patent filings, generic pharma industry practice, and the FDA's administrative procedures.

Sanofi's Orange Book entry for Lantus insulin listed 50 related patent claims. Of these, 48 were invalidated through "inter partes" review (basically the Patent Office decided they shouldn't have allowed these claims to be included on a patent). Neither of the remaining two claims were found to be relevant to the manufacture of generic Lantus.

This is where the FTC's filing comes in: their amicus brief doesn't take a position whether Sanofi's Orange Book entries were fraudulent, but they do ask the FDA to intervene to prevent Orange Book stuffing because "improper listings can cause significant harm to competition and consumers."

This is the kind of boring, technical, important stuff that excellent administrators can do. The FTC's brief is notice to the FDA that it should amend its procedures to ban (and punish) Orange Book abuse. That will make it possible for you, a person who needs medicine, to get that medicine more cheaply and quickly. In America's pay-for-use privatized healthcare hellscape, this could be a life-or-death matter.

There's plenty of things the Biden administration is getting very, very badly wrong, but we shouldn't lose sight of how its progressive wing is making real, lasting change for the better. Competent Administrations are the true peoples' champions. They beat Competent Men every time.

If you'd like an essay-formatted version of this post to read or share, here's a link to it on pluralistic.net, my surveillance-free, ad-free, tracker-free blog:

https://pluralistic.net/2023/11/23/everorangeing/#taste-the-rainbow

[robolvrr]

Hi I just finished reading your Pharma fic and I must ask for more like this but maybe some more torture? If that makes you uncomfortable then feel free to not do it!

debt collector. *. * ·

pharma x reader warnings: nsfw. mentions of medical torture. dark content. a back-alley doctor of all trades gives you deals too good to be true.

three knocks.

do you have a death wish?

the silence makes you wince. this night is bitter and your nose is ruddy, two moons overhung in the black beauty sky. gloved hands gingerly rub for friction, last ditch effort to gain some comfort. you know once this rusted door slides open, you won't be at ease and he will be there, watchful as a vulture's vice.

there should be no surprise when your miracle doctor is summoned, though you suppose the sizable difference in height and build is a factor. his smirk is a permanent fixture and what he lacks in pupils he offers in personal intrusions, crowding you inside with a croon of baritone greetings.

several mechanisms relock themselves. the mask covering the lower half of your face rolls down your chin, his colossus hands so precise, so tender, slipping your limbs free of a winter coat.

"my favorite patient. i do hope those.. prescriptions i've suggested you have been doing the trick."

originally, you had come here for the medical services. simple check-ins, an health examination every once in awhile. his rates were cheap and you had no insurance, so knowing a cybertronian of all things - billions and billions of years old no doubt with just as much field knowledge - quelled most of your concerns.

most of them.

pharma was an interesting mech. if he were a man, you're sure you'd fumble your tongue more. he has a funny way of getting you to agree with him.

"dear. i do adore our shared moments of silence just like any other, but i asked a question. how else am i to know my efficiency if you get all shy on me, mm?"

his grin tears some more seeing you squirm, mumbling an apology and turning your head as if he won't catch the warmth on your cheeks in the opposing mirror.

"sorry, pharma. to be honest.."

"yeees?" pharma sounds like he knows exactly what is bothering you.

"the medications.. they've been making me anxious. i think. i see things more than usual out of the corner of my eyes. i hear a thump and suddenly my heart is racing."

"no better than an alley cat, it seems." a grumble leaves your pout and he, still smiling wide and knowing, tuts in false concern.

"doctor, please. i know you told me these methods of yours were experimental. i'm organic. our biology is different, at its core. but i just need to sleep. that's all i need."

"all you need?"

his digit slips something gritty and round in your mouth. you swallow like the good patient you are, even though the flavor cakes your throat and makes you gag. it helps when he cups your throat, tickling the column of your neck.

he has such a way with touch. you forget you're frustrated.

"yes. i just want to sleep."

with a note of finality, his servos clap together, urging you to stay still. it may have been a few minutes, or hours, though it's unclear. there are no clocks down here. your head feels so heavy.

with a thunk, you are falling and with a grandiose hum, he is catching, placing you atop his table like a frankenstein doll.

sluggish muscles make way for well-crafted pins. acupuncture just edging discomfort, or is the fuzziness at the trim of your blank expression a sign of the end?

"then sleep you shall."

his voice echoes loud and glorious. an angel's choir - an angel of death.

the drilling pain kisses you again, fleets. you whimper, but he doesn't miss the jolt of your legs, or the shaky breath you gift his audials.

"i can gift you peace, sleeping beauty. i promise. however.. the subject of payment has been on the table for too long. i must collect."

schlick.

squishy and wet. hardness swelling where it shouldn't, nestled in your praising stare. lashes graze metal.

"speechless? you'll feel better after, sweet thing." in a corner of your mind dozens of atmospheres away, your sense of survival is thrashing in fear. it is not strong enough to pierce this hypnotic veil.

"in fact, you won't feel much at all."

pnk!

-

this room is warm and this table is cold and his hands, his hands, so big and perfect and familiar.

pharma's thumb slowly drags up along your cheek, before escaping back into his intake for him to taste-test. you think wearily that it's bright and tangy, just like the hues of his opulent frame.

"that's it. sink."

you smile.

a/n: thanks for the request! if i did get into darker stuff, like descriptive gore, i'd end up making a sideblog. also a giant prose writer so i like to leave things to the minds eye so to speak. if you can't tell, pharma and his versions of "romance" aren't sweet. will u match his freak? ;)

[mychlapci]

We need more absolutely deranged merformer aus!

I always sees mers portrayed as “almost as Cybertronians”, in terms of intelligence and acting, but what if yes, mers are indeed smart, but also like, evil little shits… like old folklore fairytales or dolphins. They intelligent but also incredibly aliens and with a totally different cultures, like, they feel love, attraction, know how to use tools, solve riddles and understand basic cybertron… but they also consider cannibalism ok.

They’re also incredibly unpredictable, they might look soft and curious, but in a matter of second they can turn into vicious killing machines that will start eating their prey before they’re drown.

So, Ratchet is somewhat an odd mer, as he’s very easy to handle. He’s kind, curious, and doesn’t show aggressive behaviors. Maybe he used to live in a part od the rust sea where contacts with land mech where at minimum, and he never had bad experiences, or maybe cause he was handled very young, it doesn’t matter. Ratchet is quite the unique specimens and Pharma can’t help himself.

It starts very easy, very innocent, Pharma would test Ratchet, both his intelligence and on a physical level, rewarding him with treats every time he acted right. Soon enough, Ratchet feels comfortable enough to be handled back and forward from his tank to the lab.

Soon, Pharma becomes obsessed with his new pet. It seems like Ratchet would let Pharma do anything to him, accepting even the most painful treatments.

At some point a new mer is introduced into the tank and he and Ratchet are immediately all over each others. If the stats is at first worried to death, they soon realize the two mers are not fighting, but mating. The new mer, someone calls him Drift, for the way he always seems to be Drifting by Ratchet’s side, some others calls him Deadlock, for how vicious he is against the staff’s members, was found hunting close where Ratchet was caught.

Pharma is livid, his Ratchet doesn’t seem interested in their games anymore, only focused on their new guest. But the doctor can’t really say anything about it, as having a living couple in the tank and being able to observe their mating rituals and maybe, even a gestation is something no other lab has been able to do.

Soon enough, Ratchet began showing signs of a possible litter growing inside his belly, and the staff comes out with a plan to release the couple of mer back into their habitats, with a localizer welded on their armor. Pharma is not happy about it, but he’s reassured in the knowledge that he will be able to track Ratchet and takes him back.

The mers are released back into the ocean and quickly disappear in the depth. Pharma keeps track of their location and during off shifts, tries to find them and lure Ratchet out, believing he will be able to attract the mer back.

In reality Ratchet has never been attracted to Pharma. Even among his kind, Ratchet is not a warrior, but a healer. He can defend himself but often prefer to play along, to study his surroundings and buying time for his bigger and way more heavy armored partner, to come to his rescue. Ratchet would often distract their enemies and potential predators, just for Deadlock to lunge in and kill them quickly and efficiently. He acted all sweet and soft with Pharma cause he had to.

But not that Pharma has come in their lair…

auhhh... Forgot about this one.

Ratchet acting docile and soft with Pharma because he's actually scared shitless of his current predicament is so interesting... He knows he can't lash out right now, that he needs to keep his cool and just tough it out until he can figure out a way to solve this. Pharma does not harm him, he's a little condescending, a little presumptuous about the level of Ratchet's intelligence, a bit clingy and overbearing, but he can handle it. Drift finds him quickly enough, and with his personality, most of the facility staff don't really bother messing with Ratchet's tank anymore. Not even Pharma.

Once they're released, Pharma wants his pet mer back. Ratchet was so good, so domesticated, so obedient, he can't be put back in with those savage mers... Pharma would honestly keep him in a tank in his home if he could. He's sure his old buddy Ratchet wouldn't mind :) Of course, he gets quite the surprise when he meets Ratchet back in the wild, his tail fat with pups... The mer is not as responsive as he was before. His wary body language turns aggressive the moment Pharma floats a little too close for comfort. Ratchet and Drift are on top of him in an instant.

And then Pharma gets torn apart and eaten <33 poor guy, but that's what he gets for trying to poach a wild mer!

[yashblower]

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[transmutationisms]

what do you think about adhd? such as the rise in drug marketing, medicalization, and globalization

i mean in broad strokes it's basically the same analysis as any other psychiatric diagnostic label lol. people experience an impairment where there's a mismatch between them and what they're socially / academically / professionally expected to be capable of. with adhd specifically the expectations here come largely from employers wanting obedient and efficient workers, and from parents and other authority figures wanting obedient and docile children. because adhd (unlike some dxs) has a very specifically targeted class of drug treatments, a lot of this also gets perpetrated by pharma interests (see: funding conflicts in academic papers, additude mag, &c) trying to encourage more use of their product, which in the current medico-legal arrangement also means pushing for more diagnoses. this is also why there's so much investment in like, studies purporting to find immutable 'brain differences' in adhd-ers and whatnot. talking about this on this site is always instantly rancid and regrettable though because people fear that the only alternative to bio-psychiatry is getting told to suck it up and be crushed in the capitalist machine, so i understand why there's so much investment from patient groups in these types of neuropsychiatric discourses. anyway i personally love to be slightly high on amphetamines and like i always say, it's morally ok to do drugs even if they're prescribed. i like a lot of jesse meadows's writing on adhd btw—they're essentially trying to find ways to talk about and accommodate what's been dx'd as their adhd, without either dismissing the real difficulties they and others experience, or falling back on essentialist psychiatric explanations.

[sigzentechnologies]

Integrating ERPNext by Sigzen : Transforming Operations in Chemical and Pharma Sectors

In the ever-evolving chemical and pharmaceutical industries, efficiency and compliance are paramount. These sectors face unique challenges such as stringent regulatory requirements, complex supply chains, and the need for precise inventory management. ERPNext, a versatile and robust open-source ERP solution, addresses these challenges head-on by offering tailored functionalities that enhance…

[spiritsofts-training-blog]

https://www.spiritsofts.com/veeva-vault-etmf-functional-training/

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[echo-circuit]

The hum of fluorescent lights filled the empty hallway as Ratchet approached the observation bay. His boots echoed sharply against the tile, a rhythm that felt too loud in the sterile quiet of the recovery wing. He hesitated at the doorway, hand hovering over the keypad. It had been months since Orion’s death—months since Shockwave had dragged himself out of the wreckage, barely alive, refusing to let go.

Ratchet inhaled sharply, bracing himself, before stepping inside.

Faint hum of machinery filled the bay, punctuated by the quiet, precise clinks of metal on metal. Shockwave sat at a workbench in the corner of the room, his posture rigid and his dark hair pulled back in a ponytail, as he adjusted the servos of his biomechanical arm. The arm, sleek but utilitarian, hung lifelessly at his side while its internal components lay exposed on the table before him. A yellow visor lay discarded on the table beside him, catching the faint light. Without it, his exposed eyes glinted faintly with an artificial sheen, their unnatural precision unsettling against the pale, hollow face they belonged to.

Ratchet stood in the doorway for a moment, taking it all in. Finally, he spoke softly as to not startle the young man. “You know, most people at least pretend to get some rest when they’re supposed to be recovering.”

Shockwave didn’t turn. “Doctor Ratchet,” he replied, his voice low, clipped, devoid of the warmth Ratchet once associated with him. “I didn’t expect a visit.”

Shockwave turned fully now, and Ratchet could see him clearly for the first time. The changes were stark. His left arm, sleek and efficient, moved with mechanical precision. His face was pale, gaunt, his features sharpened by the toll of the past months. But it was his eyes—replaced with biomechanical implants—that held Ratchet’s attention. They were too steady, too focused, and completely devoid of the warmth Shockwave once carried.

Ratchet’s chest tightened. The voice was precise, the diction perfect—yet it felt wrong. This wasn’t the Shockwave who used to debate philosophy with Orion late into the night, his face alight with youthful curiosity.

"I’m here to check on you," Ratchet said, stepping a bit closer to shockwave, His gaze flicked over the arm, the cold, mechanical design. "Your repairs look… thorough. How are you adjusting?"

Shockwave’s optics narrowed faintly. "Efficiently. The augmentations allow for greater precision and durability. Adaptation was inevitable."

"Inevitable?" Ratchet echoed, his brows knitting in anger. "Shockwave, you almost died out there. Don't listen to Pharma! You had four major surgeries to keep you alive and so soon after losing Orion—"

Shockwave finally glanced over his shoulder, his gaze cold and calculating. “Physically, I am functional. My Emotions are irrelevant. There is nothing else to discuss.”

The bluntness of the statement cut deeper than Ratchet anticipated. He cleared his throat, trying to keep his voice steady. “I’m not here as your doctor, Shockwave. I’m here as someone who—” His voice broke for a moment, and he swallowed hard. “Someone who still cares.”

"Caring is inefficient,” Shockwave said after a long pause, his gaze unwavering. “It clouds judgment. It impedes progress. You, of all people, should understand this. I do not require pity, Doctor," His tone was sharp. "My survival ensures the efficiency of the program. That is all that matters."

Ratchet flinched. The words were clinical, stripped of any personal weight. He shook his head, his fists clenching. “Don’t give me that crap,” he snapped. “This isn’t you, kid. The Shockwave I knew wouldn’t spout this emotionless drivel. He cared—deeply. About Orion, about the pilots, about everyone. What happened to that man?”

Shockwave’s expression didn’t change, but something flickered in his artificial eyes—a faint, fleeting shadow of something deeper. “That man was... inefficient,” he said quietly. “And he is gone, as Orion is gone.”

Shockwave’s jaw tightened, his gaze flickering away. He stared at the table, at the visor resting there, as if searching for answers in its polished surface.

“Existing is all that is required,” he said finally, though his voice was weary.

Ratchet exhaled heavily, his shoulders sagging under the weight of his grief. “Orion wouldn’t have wanted this for you,” he said softly. “You know that, don’t you?”

At the mention of Orion’s name, Shockwave flinched. It was subtle, almost imperceptible, but Ratchet caught it. For a brief moment, the mask of indifference cracked, and the man underneath—the one who once laughed with Orion, debated philosophy, and dreamed of a brighter future—seemed to surface.

But the moment passed quickly. Shockwave straightened, his biomechanical eyes locking onto Ratchet with unsettling precision. “What Orion wanted is irrelevant,” he said, though his voice trembled ever so slightly. “He is gone. And sentimentality will not bring him back.”

The rawness of the admission hit Ratchet like a punch to the gut. He leaned forward, resting his elbows on his knees. “That’s not true,” he said firmly. “Just because you lost Orion doesn’t mean you’ve lost yourself.”

Ratchet swallowed hard, his chest tightening at the despair he could hear in Shockwave’s voice. “I know it feels that way now,” he continued softly. “God knows, I’ve seen this happen more times than I care to count. But you’re still here, Shockwave. And as long as you’re here, there’s still a chance to heal.”

Shockwave’s gaze hardened at he looked at ratchet, his lips pressing into a thin line. “Heal?” he echoed bitterly. “Do you truly believe there is healing from this, Ratchet? Orion is dead. I felt him die. There is no rebuilding from that.”

“You’re wrong,” he said, his voice thick with emotion. “Orion believed in you. He believed in your strength, your heart. And I still believe in you, even if you don’t.”

Ratchet stepped closer, his heart breaking as he looked at the young man before him—the kid he had once mentored, once cared for like a son. “Shockwave,” he said softly, almost pleading. “Please. Talk to me. Let me help you.”

Shockwave didn’t respond, his focus unwavering as he reattached a digit to his arm. His silence was louder than any words could have been.

Ratchet sighed, his voice thick with sorrow. “You’re not the same kid who walked into that hangar all those years ago,” he said. “And maybe... maybe that kid’s gone for good. But I hope someday, you find whatever it is you’re looking for. Because God knows you can’t keep going like this.”

Shockwave’s hands paused for a fraction of a second before continuing their work. He didn’t look up, didn’t acknowledge Ratchet’s words.

Ratchet felt his throat tighten, his words catching in his chest.“I’m sorry,” he whispered, his voice barely audible. “I’m so damn sorry.”

He left the room without looking back, the echo of his footsteps swallowed by the sterile hum of the recovery wing. Behind him, the faint hum of machinery continued, the sound of a man desperately holding himself together with bolts and wires, piece by broken piece.

Sorry 😐 I've been writing this for two days, lmk if you see mistakes! 🙏

For @keferons amazing Mecha Pilot AU