#xylocaine

[ghduck]

This song is odd, but somewhat soothing at the same time

[macgyvermedical]

History of Lidocaine please?

Lidocaine was discovered in Sweden in the early 1940s.

About 1/3 of the surgeries at the time, including hernia repair and goiter, were done under local or regional anesthesia. The drug of choice for this was procaine. And frankly, procaine kind of sucked.

It was stored as a powder and needed to be mixed with saline and epinephrine very carefully in order to be useful. It degraded quickly in this mixture and was only effective for about 17 minutes once injected. It was also toxic at repeated or high doses. So surgeons had to be fairly quick about their surgeries.

And the room was there for a longer-acting, less toxic local anesthetic agent.

In 1943 a compound called LL30 was discovered. The lab personnel that discovered it had done a quick test on their own tongues, which anesthetized well. But it needed to be proven against procaine in both toxicity and effectiveness before a product could really be sold.

In 1944 the trials began. A man named Dr. Torsten Gordh headed up the experiments, using colleagues, patients, and students as test subjects. For the colleagues and patients, he offered the equivalent of about $16 in 2024 money to be in the study. For the students, they could choose between a copy of Gordh's thesis or a packet of American cigarettes.

Most of them chose the cigarettes.

The results were so stunningly superior to procaine that statistical analysis was never done. LL30 lasted a stunning 70 minutes compared to procaine's 17. It was also significantly less toxic, meaning more of it could be used.

LL30 would later be designated as lidocaine and sold under the brand name Xylocaine, which is still used today.

[killed-by-choice]

Marina DeChapell, 34 (USA 1978)

Marina DeChapell was 34 years old and had just gotten married a few months earlier when she became pregnant with her first— and only— child. According to her doctor, she had the abortion because she was scared that her unborn child had been harmed by her own health problems. It is unknown if tests were ever run to confirm this, meaning her fears might have been unfounded.

Afraid that her baby had already been harmed, Marina was referred to an abortion facility that was described by the news as “controversial and often-investigated.” Abortionist Eduardo F. Elias dosed her with Valium and Xylocaine for the abortion. He was assisted by Anne Barquet. Immediately after the first-trimester abortion (estimated to be between 6 and 8 weeks) at 620 SW 1st Street, Elias noticed she was not breathing.

Mrs. Barquet called an ambulance for Marina, but as Miami Homicide Investigator Gerald Green later told the news, “She was too far gone.” Marina showed no signs of life and was declared dead on arrival at Jackson Memorial Hospital on August 17, 1978. It was determined that she had died only moments after the abortion.

Police discovered that the abortion facility was not adequately prepared to deal with any emergency and did not have any emergency equipment except for one single air bag. It was speculated that Marina had reacted to the medication and that the facility was not equipped to save her.

Marina’s husband Fernando had been waiting for her in the office while she underwent the abortion. He was overcome with grief and shock when he learned that she was dead. In one day, he had gone from a newlywed to a widower.

Luis Barquet, the owner of the facility that killed Marina, had a criminal record and was actually in jail at the time of her death. He had been arrested before Roe v Wade for illegal abortions, sometimes as many as 5 to 10 per day. After Roe v Wade, he simply continued what he had been doing. Despite being in jail for past illegal abortion and grand larceny when Marina was killed, he was the owner of the abortion facility. Anne Barquet (formerly Anne West) was his wife and had been connected to his criminal abortions in the past. Despite her role assisting in Marina’s fatal abortion, she was not actually a nurse.

“Woman Dies After Abortion at Clinic” and obituary,

Miami Herald 8-18-1978

���Police Seek Cause Of Abortion Death,”

Miami Herald 8-19-1978

(Note: Marina’s last name is spelled differently in the news reports and in her obituary. I used the spelling from the article, but she may be referred to as Marina Dechapel or Deschapell.)

[xylocope]

xylophone :( hello xylometazoline ehllo hello xylocaine

Wgho are you and what are you doing in my house

[sadtiredboy]

I have a mosquito bite on my shoulder blade and not only is it fucking shocking mosquitoes are still around but I think this is the worst place to have a bite because I can reach to scratch it which makes the itching worse but I can’t actually apply xylocain because I always wear a shirt

[healthcarehubhh]

Lidocaine Ointment: An Overview of Pain Relief Cream for Millions

Lidocaine is a common local anesthetic drug that is frequently used to numb small areas of skin or mucous membranes. It works by blocking sodium channels in nerve cell membranes, thereby stabilizing the neuronal membrane and preventing the generation and conduction of nerve impulses associated with pain. Lidocaine was first synthesized in 1943 and has become one of the most commonly used local anesthetics worldwide. Uses of Lignocaine Ointment Lignocaine Ointment, also known by its brand names Xylocaine and LMX, is a prescription topical medication used to provide temporary relief from pain associated with minor burns, sunburn, skin irritations, shingles, post-herpetic neuralgia, and other superficial skin disorders. Lignocaine Ointment numbs nerve endings just below the skin to reduce pain. It comes as a cream, gel, or ointment that is applied to the affected area as needed for pain relief, usually up to 3-4 times daily. Lignocaine Ointment 5% is preferred for treating skin inflammation and pain. Benefits of Lidocaine Ointment Some key benefits of lignocaine Ointment include: - Provides fast-acting, temporary pain relief. Lidocaine starts working within 15-30 minutes of application and lasts for 2-4 hours. - Non-addictive. Unlike oral pain medicines, lignocaine Ointment is a topical medication and does not carry the risk of addiction. - Convenient to use. Lignocaine Ointment is easy to apply and does not require prescription for some strengths. - Widely available. It can be purchased over-the-counter without a prescription in 2.5% strength. Higher 5% strength needs prescription. - Safe for short-term use. When used as directed for a few weeks under medical guidance, lignocaine Ointment is well-tolerated and safe for most adults and children over 2 months of age. Sales and Market Opportunity According to industry analysts, the global lidocaine industry size was valued at USD 728.5 million in 2019 and is expected to expand at a compound annual growth rate (CAGR) of 5.5% from 2020 to 2027. The market growth can be attributed to growing geriatric population suffering from joint pain and arthritis, rising sports and traumatic injuries, surge in post-herpetic neuralgia cases due to increased varicella-zoster virus, and increasing preference for topical pain medications over oral drugs due to minimal systemic side effects. North America currently dominates the lidocaine market with the highest revenue share of over 35% in 2019. However, the Asia Pacific region is likely to foster highest growth during the forecast period owing to improving access to healthcare, increasing medical tourism, rising disposable incomes and healthcare spending in developing countries like India and China. The demand for lidocaine is also rising in Europe and Latin America fueled by growing awareness about topical analgesics.

[medfirstentcenter]

Septoplasty Surgery - Explained by Dr. Rajesh Bhardwaj (Award-Winning ENT Surgeon)

Septoplasty At ENT Delhi

Septoplasty is the surgical procedure to correct a deviated nasal septum (DNS).

Nasal Septum and DNS – Deviated Nasal Septum

The Nasal Septum divides the nose into the right and left nostrils.

It is made of Cartilage (malleable tissue – anteriorly), and Bone (Posteriorly).

Though ideally the Septum should be straight there is some deviation to either side in some individuals.

Causes of Deviated Nasal Septum

The child may be born with a deviated Septum due to pressures in the womb.

Injury- while growing up, or as a child while playing games, or sometimes after and accident.

Pressure of swelling like large growth/ polyp on one side of the nose can push the septum to the other side.

INDICATIONS OF SEPTOPLASTY

Nasal Blockage

Recurrent Nasal bleeding

Snoring and sleep Apnoea

As an approach or access to Nasal Surgery like FESS or skull base surgery

To repair a nasal septal deviation

Anaesthesia for Septoplasty

Local Anaesthesia – after discussing with the patient – only Local Anaesthetic is used along with some sedation

MAC- Monitored Anaesthesia Care- the anaesthetist gives pain reliving drugs intravenously, along with sedation.

General Anaesthesia – Full General Anaesthesia where the patient is completely unconscious.

The decision regarding the type of anaesthesia to be used is taken following a discussion between the ENT surgeon and the patient.

METHOD OF SEPTOPLASTY

Septoplasty is a very commonly performed surgical procedure.

In the Operation Theatre, after cleaning and draping the patient 2 % Xylocaine with adrenaline is injected into the septum so as to lift a submucosal flap. Cotton patties with 4 % Xylocaine and adrenaline are sometimes placed in the nasal passage as well to help shrink the mucosal swellings.

Depending upon the nature of the deviation an incision is made on the Septum and mucosal flaps are lifted and joined together – the septum is now standing freely and unattached.

The Septum is then brought to the midline using various techniques, including thinning out duplicated parts, straightening and morselization as well as using a hammer and gouge to remove bony spurs.

Once the septum is brought to the midline parts may be sutured – either at the caudal (lower) end or sutures to approximate septal flaps together so as to prevent haematoma formation.

Nasal packs are placed in the nose which are kept in situ for a day or sometimes longer.

POST OPERATIVE PERIOD

The post operative period is usually uneventful – the patient takes rest for a day or two. We recommend to work from home for about 5-7 days or till the wound has healed.

Normal diet is recommended- simple regular home food.

Lying propped up in bed is usually helpful

There may be some pink/ blood soaked discharge from the nose for a few days

Do not blow nose

No steam inhalation in the immediate post operative period

Must come for regular follow up visits as asked for

COMPLICATIONS

Though a safe and well tolerated surgical procedure, Septoplasty can lead to some complications.

Bleeding – in the immediate post operative period, or sometimes after a week to 10 days- a well known complication called Secondary haemorrhage. Treatment is usually simple.

Infection – every surgical procedure can be followed by a local infection in the affected area- a good antibiotic is usually enough to treat this.

Nasal Septal Perforation- in spite of all precautions sometimes there can be a septal perforation due to flap necrosis.

External nasal deformity- sometimes, if excessive supportive tissue is sacrificed the nasal pyramid may be affected – usually in the form of a supra tip depression.

Recurrence- though airway improvement is predictable sometimes the septal deviation may spring back either as a result of fresh trauma or due to strong tissue.

MedFirst ENT Centre Advantage - Septoplasty with Health Insurance and TPA Support

MedFirst ENT Centre specializes in septoplasty and is committed to providing a seamless experience for patients seeking this medical care. They facilitate the financial aspects of septoplasty treatment through affiliations with leading insurance companies, with a dedicated Third Party Administrator (TPA) team well-versed in handling septoplasty claims. Whether patients require care under a group health insurance plan or individual/family health insurance for their septoplasty, MedFirst ENT Centre’s extensive network and TPA team ensure smooth processing of septoplasty health insurance claims, relieving patients of administrative burdens.

Understanding how health insurance policies and TPAs can assist in covering septoplasty costs is essential. Septoplasty, a procedure aimed at correcting a deviated nasal septum, is often a medical necessity to improve breathing and overall health. To ensure a smooth and cost-effective septoplasty experience, proactive measures include thoroughly reviewing insurance policies, selecting specialized ENT clinics within the insurance network, and collaborating with TPAs for efficient claims processing. This proactive approach ensures that patients can undergo septoplasty with confidence, knowing their insurance covers the procedure, providing peace of mind during the septoplasty journey.

ENDOSCOPIC SEPTOPLASTY

With the advent of the endoscope ENT Surgeons are now performing minimal 

access Endoscopic guided Septoplasty surgery. You must discuss this with your 

surgeon- not all septal deviations can be corrected by endoscopic septoplasty.

#Septoplasty #ENTProcedure #NasalHealth #DrRajeshBhardwaj #ENTCare #SurgicalCorrection #SeptalDeviations #HealthcareExpertise #ENTSpecialist #MedicalProcedure #NasalWellness #SeptoplastyExplained #HealthcareExcellence #SurgicalInnovation #PatientEducation #ExpertENTCare #ENTInsights #ImprovedBreathing #NasalSurgery #AwardWinningSurgeon

[grace-qian]

Xylocaine cas #137-58-6 Xylocaine

[General Description]Lidocaine was the first amino amide synthesized in 1948and has become the most widely used local anesthetic. Thetertiary amine has a pKa of 7.8 and it is formulated as thehydrochloride salt with a pH between 5.0 and 5.5. When lidocaineis formulated premixed with epinephrine the pH ofthe solution is adjusted to between 2.0 and 2.5 to prevent the hydrolysis of the epinephrine.…

[lupine-publishers-juns]

Lupine Publishers | Evaluation of Buccal Mucosal Graft Urethroplasty for The Treatment of Female Urethral Strictures- A Single Centre Experience

Abstract

Introduction: Female urethral stricture is a highly under-reported and underdiagnosed condition encountered by the reconstructive urologist. Urethral dilatation is often performed with urethroplasty offered in select cases. In the present study, we describe our results in a series of women surgically treated for female urethral stricture disease using a suprameatal approach with a buccal mucosal graft dorsal on lay technique. Materials and Methods: All females diagnosed of urethral stricture who underwent buccal mucosal graft urethroplasty from January 2015 to January 2020 were evaluated retrospectively. Intraoperative and postoperative parameters were assessed. Results: A total of 14 female patients underwent buccal mucosal urethroplasty were evaluated. The mean age of the patients was 49.5 years ranging from 35 to 64 years. Mean preoperative maximum flow rate [Qmax] on uroflometry was 6.5 ml/second and the mean residual urine 156 ml. All patients underwent uneventful buccal mucosal graft dorsal on lay technique. At 3 months follow up, the mean Qmax was 23.2 ml/second with mean residual urine of 14 ml. A Self-reporting satisfaction scores using the Patient Global Impression of Improvement showed that seven patients scored 1 (very much better), four scored 2 (much better), two patients scored 3 (a little better), and one scored 4 (no change) none of the patients scored a 5 (worse).No recurrence was noted. Conclusion: Buccal mucosal graft urethroplasty is a feasible surgery for female urethral strictures with minimal short term complications

Keywords: Buccal Mucosal Graft Urethroplasty; Female Urethral Strictures

Introduction

Female urethral stricture is a highly under-reported and underdiagnosed condition encountered by the reconstructive urologist. The aetiology of urethral stricture is still unclear. Symptoms range from clinically insignificant to severe and debilitating voiding symptoms. Urethral dilatation has been overused for primary and chronic treatment. Urethroplasty with various grafts and flaps have been used with good results in recent times. In this present study, we describe our results in a series of women surgically treated for female urethral stricture disease using a suprameatal approach with a buccal mucosal graft dorsal on lay technique.

Patients and Methods

A total of 14 female patients with urethral stricture who underwent buccal mucosal graft urethroplasty from January 2015 to January 2020 were evaluated retrospectively. Patients were evaluated with a detailed history, physical examination including focused neurological evaluation, uroflometry, a micturating cystourethrogram and an ultrasound of abdomen and pelvis. Evaluation also included a gentle calibration of urethra with a 14 French catheter to assess the site of stricture. All patients had a history of poor stream of urine, 10 (71%) had a sense of incomplete voiding, 2 (14%) presented with recurrent urinary tract infection and 2 (14%) patients had terminal dribbling. Aetiology of the stricture was idiopathic in 9 (64%) of the patients, instrumentation in 3 (22%) and catheterization in 2 (14%). More than half, that is 8 (57%) of the patients had history of repeated urethral dilatation.

Surgical technique

Routine preoperative antibiotic prophylaxis was given and under general anaesthesia with nasal intubation, the surgery was performed in lithotomy position. An initial Urethroscopy was performed with a 6 French ureteroscope to assess the site of stricture, the proximity of the stricture to the bladder neck and any abnormalities in the bladder and trigone. A diluted mixture of 2% xylocaine and adrenaline was injected submucosally into the periurethral tissue using a 26 gauge needle for hydro dissection and haemostasis. An inverted ‘U’ shaped incision (Figure 1A) was given over the urethra exposing the dorsal part of the urethra. Sharp dissection was then done in order to separate the vulvar mucosa from the urethra (Figure 1B). Utmost care was taken to prevent damage to the clitoral cavernous tissue and the anterior portion of the striate sphincter. A full thickness urethrotomy was made using tenotomy scissors at 12 ‘O’ clock position over a guide wire and then extended proximally till normal healthy mucosa could be visualised. The urethra was then calibrated with 18 French catheter to rule out proximal stricture.

The buccal mucosal graft was then harvested. The Stenson’s duct was marked opposite the upper second molar tooth. Methylene blue was used to mark the graft area to be harvested. A diluted mixture of 2% xylocaine and adrenaline was injected submucosally using a 26 gauge needle for hydrodissection and hemostasis. The buccal mucosal graft was harvested based on the length of the stricture. Haemostasis was achieved with bipolar cautery and the raw area was packed with adrenaline soaked gauze. Buccal mucosa was allowed to heal by secondary intention. Defatting of the graft was performed and the graft was placed in a container with gentamycin and saline. An 18 French catheter was then introduced into the urethra and bulb was inflated. The buccal graft was then sutured to the apex at 11, 12 and 1 ‘0’ clock position (Figure 1C). The lateral margins of the urethra and buccal mucosa were sutured in a dorsal on lay fashion with 4-0 vicryl suture (Figure 1D). This augmented urethra was then quilted to the clitoral body to cover the new urethral roof (Figure 1E). Vulvar mucosa was then approximated with 4-0 vicryl suture. Patients were discharged with catheter after 2 days and were called for catheter removal after 3 weeks (Figures 2A-2D). Patients were followed up after 3 months with assessment of voiding symptoms, examination (Figure 3), uroflometry and a micturating cystourethrogram. The criteria of successful reconstruction were defined as postoperative maximum flow rate (Qmax) greater than 15ml/sec with minimal post void residue (<10% of pre-void). A Self-reporting satisfaction scores using the Patient Global Impression of Improvement was used for assessment of urinary symptoms at 3 months follow up. At subsequent follow ups, the patients were assessed with voiding symptoms and an uroflometry. 

Results

A total of 14 female patients underwent buccal mucosal urethroplasty from January 2015 to January 2020. The mean age of the patients was 49.5 years ranging from 35 to 64 years. Mean preoperative maximum flow rate [Qmax] on uroflometry was 6.5ml/ second ranging from 4 to 7.2ml/second (Table 1). The mean residual urine was 156 ml. In all the patients, calibration with 14 Fr catheter was not possible preoperatively. The mean operative time was 96 minutes ranging from 84 minutes to 116 minutes. Mean stricture length was 1.4 centimetres ranging from 1 to 2.2 centimetres. The mean length of the harvested graft was 2.5 cms ranging from 2.0 to 3.5 cms. Our mean follows up period was 22 months ranging from 6 months to 45 months. None of the patients developed any evidence of graft necrosis post operatively. No wound infection was noted in our series. No donor site complication was noted in our series. Mean hospital stay was 2.5 days ranging from 2-4 days. At 3 months follow up, the mean Qmax was 23.2 ml/second with mean residual urine of 14ml. A Self-reporting satisfaction scores using the Patient Global Impression of Improvement was used which showed that that seven patients scored 1 (very much better), four scored 2 (much better), two patients scored 3 (a little better), and one scored 4 (no change) none of the patients scored a 5 (worse) (Table 2). None of the patients developed recurrence, incontinence, or sexual dysfunction during the course of our follow up.

Discussion

Female urethral stricture has been described for almost 200 years but is still a widely underdiagnosed condition [1]. Brannen described the history of female urethral stricture and said that it was first described by Liz Frank in 1824 and the first case of female urethral stricture was reported to the earl of London in 1828 [2]. The exact incidence of this entity remains unknown with very few case reports and retrospective case series reported in contemporary literature till date [3]. The aetiology for female urethral stricture has been attributed to idiopathic (49%), chronic irritation, Prior dilatation, catheterization, instrumentation (7%) and trauma (6%) [4-7]. Trauma may be in the form of obstetric injuries, blunt pelvic trauma, or even repeated vigorous coitus [2]. In our study, idiopathic stricture was the most common cause accounting for 64% of the cases. Patients usually present with long standing complaints of voiding and storage symptoms, recurrent urinary tract infections and sometimes upper urinary tract changes. Irritative voiding symptoms may be the presenting complaint in 35% of the patients [8]. Evaluation of the patients include a detailed history including history of stress and urge incontinence, local examination of the meatus, uroflometry and measurement of residual urine. Examination should also include gentle calibration with a 14 French catheter [9]. Radiological evaluation of the stricture with a micturating cystourethrogram helps visualise the stricture. Options for management of these strictures include urethral dilatation, urethroplasty with grafts (oral/vaginal) or flaps (vaginal/labial) [4]. Urethral dilatation alone has a dismal success rate of 47% at a mean follow up of 43 months [4]. The mean time to recurrence of stricture has been reported to be around 12 months [10]. Dilatation combined with daily intermittent self-catheterization is said to have a success rate of 57% [10,11]. Like in males, it appears that, if a single dilatation fails, then it is probable that further dilatations are likely to be palliative rather than curative [4]. Urethral reconstruction in women is different from that of men because of the shorter length of the urethra and that the female urethra is sphincter active. Hence any urethral surgery in the female carries a substantial risk of incontinence. Anastamotic urethroplasty has not been described till date. The various approaches to urethral reconstruction are ventral approach or a dorsal approach. We preferred the dorsal approach because of the good mechanical and vascular support provided by the clitoral and cavernosal tissue, it prevents the downward angulation of the urethral meatus, which may have a subsequent impact on the direction of the urinary stream and further, it spares the ventral aspect of urethra for further anti-incontinence surgery. The disadvantages being increased chances injury to the sphincter and neurovascular bundle which may lead to in continence or sexual dysfunction. A total of 15 studies with 115 patients described urethroplasty for female urethral strictures, with 6 studies describing flaps and 10 studies describing the use of free grafts for urethral augmentation [4]. A total of 6 studies have described the use of oral grafts for female urethral strictures [12-17]. The individual success rate with the use of oral mucosal graft was 94% with a mean follow up of 15 months [4]. There were no reported incidences of de novo incontinence. Oral mucosa is particularly helpful when vaginal atrophy and fibrosis precludes the use of a local flap. In our series, there were no cases with recurrence and none of the patients complained of urinary incontinence post op. With the use of vaginal or labial grafts, the success rate was reported to be around 80% at a mean follow up of 22 months [4]. Successful outcome with the use of vaginal flaps is reported to be around 91% at 32 month follow up. The main drawbacks of this study are the retrospective nature of study, lack of control group and short term follow up. A randomized study with a control group and long term follow up is needed to further validate this procedure.

Conclusion

Buccal mucosal graft urethroplasty is a feasible surgery for female urethral strictures with minimal short term complications.

For more Lupine Journals please click here: https://lupinepublishers.com/index.php

For more  Journal of Urology & Nephrology Studies  articles please click here: https://lupinepublishers.com/urology-nephrology-journal/index.php

[ed-fast-delivery]

About Xylocaine 10% Spray 50 ml

About Xylocaine 10% Spray 50 ml

Xylocaine 10% Spray 50 ml belongs to the class of local anaesthetics used to reduce/relieve pain and discomfort associated with skin irritation, burns, scratches, insect bites, skin abrasions, or sunburn. It is also used to treat post-herpetic neuralgia (lasting pain after a shingles infection). Xylocaine 10% Spray 50 ml may also be used to treat premature ejaculation. It is also indicated for the prevention and control of pain in urethritis (inflammation of the urethra). Xylocaine 10% Spray 50 ml may also be used as an adjunct for endotracheal intubation.

 Xylocaine 10% Spray 50 ml contains 'lidocaine' that blocks the influx (entry) of sodium ions into the membrane that surrounds the nerves, thereby preventing initiation and conduction of impulses. Xylocaine 10% Spray 50 ml produces local numbness by blocking the nerve signal in the affected area. Hence, Xylocaine 10% Spray 50 ml produces an anaesthetic effect and helps decrease the sensation of pain.

Use Xylocaine 10% Spray 50 ml as advised by the doctor. In some cases, Xylocaine 10% Spray 50 ml may cause application site reactions such as burning sensation, itching, redness, and irritation. Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side effects persistently.

 Uses of Xylocaine 10% Spray 50 ml

Reduce/relieve pain and discomfort (local anaesthesia), post-herpetic neuralgia, premature ejaculation, as an adjunct for endotracheal intubation.

Medicinal Benefits

Xylocaine 10% Spray 50 ml belongs to the class of local anaesthetics used to reduce/relieve pain and discomfort associated with skin irritation, burns, scratches, insect bites, skin abrasions, or sunburn. It is also used to treat post-herpetic neuralgia (pain due to shingles-a viral infection). Xylocaine 10% Spray 50 ml is also indicated for the prevention and control of pain in urethritis (inflammation of the urethra). Xylocaine 10% Spray 50 ml may also be used as an adjunct for endotracheal intubation (a medical procedure involving the placement of a tube into the windpipe through the nose or mouth).

Directions for Use

Xylocaine liquid/Gel/Ointment/Jelly: Use it as advised by the doctor. Apply the prescribed dose onto the affected area.Spray: Shake the container before use. Point the nozzle towards the application site and press the button to spray. Do not puncture, incinerate, or break the container, even if it is empty.Patch: Apply the patch to the affected area. Do not handle the patch with wet hands. Avoid bathing/showering/swimming while wearing the patch.

Side Effects of Xylocaine 10% Spray 50 ml

Burning sensation,Itching

Redness

Irritation.

[ghduck]

Question #4

What is your favorite song (if you have one)?

Mine is "Rural Area" by Xylocaine

[the-graveyard-sys]

rabbits are rabbits are rabbits are rabbits are rabbits are rabbits are rabbits are rabbits are blood vessel contraction agent tetrahydrozoline hydrochloride added

inaba is inaba is inaba is inaba is inaba is inaba is inaba is inaba is stops at the affected area and immediately dissolves and eases symptoms such as high fever

udonge udonge udonge udonge udonge udonge udonge udonge eight different ingredients, including lidocaine which relieves pain, will heal the affected area

stops at the affected area and immediately dissolves and eases symptoms such as high fever blood vessel contraction agent tetrahydrozoline hydrochloride added

fun aesop nerd fact: lidocaine is a painkiller, tetrahydrozoline hydrochloride is used in eyedrops. some versions of the song mention dexmedetomidine which is a sedative and xylocaine which is also a painkiller. tetrahydrozoline hydrochloride relieves eye redness by causing blood vessels in the eye to contract, its also not used very much anymore due to the pretty high side effects

[anarchist-caravan]

Xylocaine - 440Hz - Experiment in Fear (1995)

[stellacras]

you make me mad like a weed

[siglerprescriptiondrugcards]

Lidocaine Hydrochloride

Common Brand Names: Xylocaine

Therapeutic Class: A local anesthetic also used as an antiarrhythmic (Class Ib)

Common Injectable Dosage Forms:

Injection: 300 mg/3 mL (IM only), 20 mg/mL, and 40 mg/mL for direct IV injection, and 40 mg/mL, 100 mg/mL, and 200 mg/mL for preparation of IV infusions. Also available in premixed infusion bags of 4 mg/mL and 8 mg/mL

Dosage Ranges:

For initial treatment of ventricular arrhythmias: The adult bolus IV injection is 50-100 mg or 1-1.5 mg/kg. If desired response is not obtained, a repeat dose may be given in 5 minutes. Manufacturers recommend a maximum of 200-300 mg during a 1-hour period. Maintenance infusions are usually terminated as soon as stable due to possibility of accumulation and toxicity. IM doses of lidocaine are recommended at 300 mg or 4.3 mg/kg and repeated in 60-90 minutes if necessary.

In children, suggested doses are bolus of 0.5-1 mg/kg with total bolus doses not to exceed 3-5 mg/kg, and maintenance infusions of 20-50 mcg/kg/minute.

Therapeutic Drug Level: Between 1.5-6 µg/mL

Administration and Stability: IM administration of the 100 mg/mL solution should be done deeply into the deltoid muscle if possible. For direct IV bolus injection, only the 10 mg/mL or 20 mg/mL solutions should be used and administered at a rate of 25-50 mg/minute. For preparation of maintenance IV infusions, 1 gram should be added to 1000 mL of D5W to provide a 1 mg/mL solution. Alternatively, the commercially available solution may be used. If fluid restrictions are a consideration, concentrations of up to 8 mg/mL are considered appropriate. pH 5-7

Pharmacology/Pharmacokinetics: Lidocaine exhibits membrane-stabilizing antiarrhythmic (Class I) properties by combining with fast sodium channels during their inactive state to inhibit repolarization. This results in suppressed automaticity in the His-Purkinje system and suppressed spontaneous depolarization in the ventricles during diastole. Following IV administration, onset of action is 45-90 seconds with effects lasting up to 10-20 minutes. The drug is widely and rapidly distributed into body tissues, is extensively metabolized to active metabolites in the liver, and eliminated via the urine. The elimination half-life is 1.5-2 hours.

Drug and Lab Interactions: CIMETIDINE and PROPRANOLOL substantially reduce clearance of lidocaine and may result in toxicity. Concomitant use with other antiarrhythmics such as phenytoin, procainamide, propranolol, or quinidine may result in additive or antagonistic effects. May increase neuromuscular blocking effects of succinylcholine.

Contraindications/Precautions: Contraindicated in patients with known hypersensitivity to other amide-type local anesthetics. Should be used with caution in patients with severe renal disease, liver disease, congestive heart failure, Wolff-Parkinson-White syndrome, or any other form of heart block. Continuous ECG monitoring should be performed during lidocaine administration. Pregnancy Category B.

Adverse Effects: Adverse effects mainly involve the CNS and are dose related. Reported effects include drowsiness, dizziness, confusion, and dyspnea. Toxicity may be manifested by hypotension, bradycardia, and cardiovascular collapse. Local thrombophlebitis may occur with prolonged IV infusions.

Common Clinical Applications: Effective in the acute treatment of ventricular arrhythmias associated with myocardial infarction or cardiac surgery or catheterization.

[leandra-kinard]

Aus dem gleichen Grund, warum dein Suppenfleisch (oder eben auch deine Haut) weich wird, wenn es lang und stark genug erhitzt wird: Proteinketten lösen sich auf. Der Inhalt des Speichels der Stechmücken besteht aus Proteinen. Tadaa. Juck-juck kaputt. Deswegen sollte das auch schnell geschehen, weil sich die Proteine sonst zu weit im Gewebe verteilen.

Anderer und wenig gefährlicher Pro-Tip, falls ihr den Zeitpunkt fürs Erhitzen verpasst habt. Xylocain Gel 2% in der Apotheke kaufen. Ist ein Gleitmittel, was für so Dinge wie Magen und Darmspiegelungen eingesetzt wird. Der Wirkstoff (ein lokales Anästhetikum) wird aber in anderen Ländern (z.B. Australien) in Mückenstichgels eingesetzt, da es die oberste Hautschicht leicht betäubt und den Juckreiz unterbricht. Wirkt bei mir tausend Mal besser als jedes Fenistil und Soventol.

Fakt: Konzentriert eingesetzte Hitze hilft gegen Mückenstiche.

zusätzlicher Fakt: Wenn man keinen von diesen schicken Hitzestiften aus der Apotheke hat, kann man auch einfach eine Tasse mit heißem Wasser an den Stich halten.

SEHR WICHTIGER FAKT: Wenn man ein Depp ist und sich denkt "lol viel hilft viel" kann man sich die Haut verbrennen.

zusätzlicher Fakt: Eine Brandblase tut zwar ein bisschen weh, aber sie juckt nicht.

Fazit: Alles richtig gemacht.