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deshpandeisha · 1 day

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Innovative Approaches to Menopausal Therapy: Balancing Hormones Naturally

The global menopausal therapy market size was USD 16.10 Billion in 2022 and is expected to register a steady revenue CAGR of 5.3% during the forecast period, according to latest analysis by Emergen Research. Increasing prevalence of post-menopausal symptoms owing to shift towards a sedentary lifestyle and rising vasomotor and menopausal symptoms, such as night sweats and hot flashes, among women during menopausal transition are major factors driving market revenue growth. Menopause is a natural stage of aging, in which a woman's period and her ovaries cease to act reproductively. This usually happens between the age of 45 and 55. Average age in the UK is 51, however, one in every 100 women experiences menopause before the age of 40.

The analysis of the recent advancements in the Menopausal Therapy industry and trends driving the growth of the market. It is an investigative study covering analysis of market drivers, restraints, challenges, threats, and growth prospects in the global Menopausal Therapy market. The global Menopausal Therapy market report is a methodical research of the Menopausal Therapy market done by extensive primary and secondary research. The fundamental purpose of the Menopausal Therapy market report is to offer an accurate and strategic analysis of the Menopausal Therapy business sphere.

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Competitive Terrain:

The global Menopausal Therapy industry is highly consolidated owing to the presence of renowned companies operating across several international and local segments of the market. These players dominate the industry in terms of their strong geographical reach and a large number of production facilities. The companies are intensely competitive against one another and excel in their individual technological capabilities, as well as product development, innovation, and product pricing strategies.

The leading market contenders listed in the report are:

Bayer AG, Theramex, AbbVie Inc., Abbott Laboratories, Pure Encapsulations, LLC, Rainbow Lights, Pfizer Inc., Eli Lily and Company, Cipla Inc., and Amgen Inc.

Key market aspects studied in the report:

Market Scope: The report explains the scope of various commercial possibilities in the global Menopausal Therapy market over the upcoming years. The estimated revenue build-up over the forecast years has been included in the report. The report analyzes the key market segments and sub-segments and provides deep insights into the market to assist readers with the formulation of lucrative strategies for business expansion.

Competitive Outlook: The leading companies operating in the Menopausal Therapy market have been enumerated in this report. This section of the report lays emphasis on the geographical reach and production facilities of these companies. To get ahead of their rivals, the leading players are focusing more on offering products at competitive prices, according to our analysts.

Report Objective: The primary objective of this report is to provide the manufacturers, distributors, suppliers, and buyers engaged in this sector with access to a deeper and improved understanding of the global Menopausal Therapy market.

Emergen Research is Offering Limited Time Discount (Grab a Copy at Discounted Price Now)@ https://www.emergenresearch.com/request-discount/1676

Market Segmentations of the Menopausal Therapy Market

This market is segmented based on Types, Applications, and Regions. The growth of each segment provides accurate forecasts related to production and sales by Types and Applications, in terms of volume and value for the period between 2022 and 2030. This analysis can help readers looking to expand their business by targeting emerging and niche markets. Market share data is given on both global and regional levels. Regions covered in the report are North America, Europe, Asia Pacific, Latin America, and Middle East & Africa. Research analysts assess the market positions of the leading competitors and provide competitive analysis for each company. For this study, this report segments the global Menopausal Therapy market on the basis of product, application, and region:

Segments Covered in this report are:

Product Outlook (Revenue, USD Billion; 2019-2032)

Hormone Therapy

Non-hormone Therapy

Distribution Channel Outlook (Revenue, USD Billion; 2019-2032)

Hospital Pharmacies

Retail Pharmacies

Online

Regional Outlook (Revenue, USD Billion; 2019–2032)

North America

U.S.

Canada

Mexico

Europe

Germany

France

Italy

Spain

Benelux

Rest of Europe

Asia Pacific

China

India

Japan

South Korea

Rest of APAC

Latin America

Brazil

Rest of LATAM

Middle East & Africa

Saudi Arabia

UAE

South Africa

Turkey

Rest of Middle East & Africa

Browse Full Report Description + Research Methodology + Table of Content + Infographics@ https://www.emergenresearch.com/industry-report/menopausal-therapy-market

Major Geographies Analyzed in the Report:

North America (U.S., Canada)

Europe (U.K., Italy, Germany, France, Rest of EU)

Asia Pacific (India, Japan, China, South Korea, Australia, Rest of APAC)

Latin America (Chile, Brazil, Argentina, Rest of Latin America)

Middle East & Africa (Saudi Arabia, U.A.E., South Africa, Rest of MEA)

ToC of the report:

Chapter 1: Market overview and scope

Chapter 2: Market outlook

Chapter 3: Impact analysis of COVID-19 pandemic

Chapter 4: Competitive Landscape

Chapter 5: Drivers, Constraints, Opportunities, Limitations

Chapter 6: Key manufacturers of the industry

Chapter 7: Regional analysis

Chapter 8: Market segmentation based on type applications

Chapter 9: Current and Future Trends

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Emergen Research is a market research and consulting company that provides syndicated research reports, customized research reports, and consulting services. Our solutions purely focus on your purpose to locate, target, and analyse consumer behavior shifts across demographics, across industries, and help clients make smarter business decisions. We offer market intelligence studies ensuring relevant and fact-based research across multiple industries, including Healthcare, Touch Points, Chemicals, Types, and Energy. We consistently update our research offerings to ensure our clients are aware of the latest trends existent in the market. Emergen Research has a strong base of experienced analysts from varied areas of expertise. Our industry experience and ability to develop a concrete solution to any research problems provides our clients with the ability to secure an edge over their respective competitors.

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adoctorx · 9 days

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Veozah (fezolinetant) is a prescription drug used to treat certain symptoms of menopause. Veozah can cause side effects that range from mild to serious. Examples include hot flashes and abdominal pain. Specifically, Veozah is used in adults to treat moderate to severe vasomotor symptoms caused by menopause. Examples of vasomotor symptoms include night sweats and hot flashes. Veozah comes as an oral tablet and contains the active ingredient fezolinetant. Keep reading to learn about common, mild, and serious side effects Veozah can cause. For a general overview of the drug, including details about its uses, see this article. What are the more common side effects of Veozah? Some people may experience mild to serious side effects during Veozah treatment. Examples of the drug’s commonly reported side effects include: abdominal pain diarrhea insomnia back pain hot flashes* * To learn more about this side effect, see the “Side effects explained” section. What are the mild side effects of Veozah? Mild side effects have been reported with Veozah. These include: abdominal pain diarrhea insomnia (difficulty sleeping) back pain hot flashes* In most cases, these side effects should be temporary. And some may be easily managed. But if you have symptoms that are ongoing or bothersome, talk with your doctor or pharmacist. And do not stop taking Veozah unless your doctor recommends it. See Veozah’s prescribing information for details, including specifics about how often side effects occurred in the drug’s studies. * To learn more about this side effect, see the “Side effects explained” section. What are the serious side effects of Veozah? Elevated liver enzymes have been reported with Veozah. To learn more about this side effect, see the “Side effects explained” section. If you develop serious side effects while taking Veozah, call your doctor right away. If the side effects seem life threatening or you think you’re having a medical emergency, immediately call 911 or your local emergency number. Note: After the Food and Drug Administration (FDA) approves a drug, it tracks and reviews side effects of the medication. If you’d like to notify the FDA about a side effect you’ve had with Veozah, visit MedWatch. Allergic reaction For some people, Veozah can cause an allergic reaction, but this side effect wasn’t reported in the drug’s studies. What might help If you have mild symptoms of an allergic reaction, such as a mild rash, call your doctor right away. They may suggest a treatment to manage your symptoms and can determine whether you should keep taking Veozah. If you have symptoms of a severe allergic reaction, such as swelling or difficulty breathing, call 911 or your local emergency number right away. These symptoms could be life threatening and require immediate medical care. If your doctor confirms you’ve had a serious allergic reaction to Veozah, they may have you switch to a different treatment. FAQ about Veozah’s side effects Get answers to some frequently asked questions about Veozah’s side effects. Does Veozah cause weight gain or weight loss? No, it’s not believed to. Neither weight gain nor weight loss were reported as side effects in studies of Veozah. Veozah is prescribed to treat moderate to severe vasomotor symptoms caused by menopause. Gradual weight gain during menopause is common. There are numerous factors that determine why some women gain weight around menopause, including your genetics and lifestyle. But Veozah isn’t expected to cause weight gain or weight loss. Talk with your doctor if you have questions or concerns about your weight and what factors could influence it. Does Veozah have any contraindications? Yes, Veozah has several contraindications. A contraindication is a reason (a condition or factor)for a person to not be prescribed a certain drug due to the risk of harm. Veozah has three contraindications:

Cirrhosis (severe scarring of the liver): Your liver helps break down Veozah after you take a dose. If you have cirrhosis, the level of Veozah in your system could become too high. This increases your risk of side effects from the medication. Severe renal (kidney) problems, including end stage kidney disease (ESRD): After your body breaks down Veozah, most of the drug leaves your body through urine. Severe kidney problems, including ESRD, could cause the level of Veozah to build up in your body. This raises the risk of side effects from the drug. Use with drugs that block the enzyme CYP1A2: CYP1A2 is an enzyme made by your liver that helps break down certain medications, including Veozah, in your body. Taking a drug that blocks CYP1A2 along with Veozah can increase the level of Veozah in your system. This increases your risk of Veozah’s side effects. Examples of medications that block CYP1A2 include ciprofloxacin (Cipro) and fluvoxamine (Luvox). Talk with your doctor or pharmacist if you’d like to learn more about contraindications for Veozah, including whether they apply to you. Side effects explained Learn more about some of the side effects Veozah may cause. Hot flashes Hot flashes were a common side effect reported in studies of Veozah. While common compared to other side effects, most people who took Veozah in these studies did not experience hot flashes as a side effect. Hot flashes may cause symptoms such as: a sudden warm feeling in your skin getting red or flushed in the face sweating tingling in your fingers heart palpitations It’s important to note that hot flashes are also a common menopause symptom. It may be difficult to tell whether your symptoms are a side effect of Veozah or a symptom of menopause. Veozah is prescribed to treat hot flashes caused by menopause, which complicates addressing this side effect. Certain factors can trigger a hot flash. These triggers vary from one person to another, but some examples include: consuming alcohol or caffine eating spicy foods feeling anxious or stressed wearing tight clothing What might help There are several strategies to help prevent or treat hot flashes. First, if you can figure out your triggers, avoiding them can help prevent hot flashes. It may be helpful to keep a journal about your symptoms and try to identify what may trigger them. Some tips to help relieve hot flash symptoms include sipping ice water and practicing stress reduction techniques such as yoga or guided breathing. If you have persistent hot flashes during Veozah treatment, talk with your doctor. They may recommend trying a different medication to treat your menopause symptoms. Elevated liver enzymes Elevated liver enzymes were a side effect reported in studies of Veozah but weren’t common. Elevated liver enzymes usually don’t cause symptoms. While it’s rare, they can be a sign of liver damage or other problems. However, liver damage was not reported as a side effect in studies of Veozah. If you have an existing liver problem, you may have a higher risk of this side effect. It’s also possible that taking Veozah could worsen your condition. What might help Before you start Veozah treatment, your doctor will likely order blood tests, including a liver function test, to check your liver enzyme levels. If these levels are high, your doctor may not prescribe Veozah for you. They may also reorder these blood tests periodically throughout your Veozah treatment. While taking Veozah, immediately notify your doctor if you experience symptoms of liver problems. Examples include jaundice (yellowing of your skin or the whites of your eyes), and stool that is pale, black, or bloody. Due to this risk, doctors typically won’t prescribe Veozah if you have a severe liver problem, including cirrhosis. Keeping track of side effects During your Veozah treatment, consider taking notes on any side effects you’re having.

You can then share this information with your doctor. This is especially helpful when you first start taking a new drug or using a combination of treatments. Your side effect notes can include things such as: what dose of the drug you were taking when you had the side effect how soon you had the side effect after starting that dose what your symptoms were how your symptoms affected your daily activities what other medications you were taking any other information you feel is important Sharing notes with your doctor will help them learn more about how Veozah affects you. They can then use this information to adjust your treatment plan if needed. Warnings for Veozah Veozah can sometimes cause harmful effects in people with certain conditions. This is known as a drug-condition interaction. Other factors may also affect whether Veozah is a good treatment option for you. Talk with your doctor about your health history before taking Veozah. Be sure to tell them if any of the following factors apply to you: kidney problems, such as chronic kidney disease or ESRD liver problems, especially cirrhosis previous allergic reaction to Veozah pregnancy breastfeeding alcohol consumption Disclaimer: Healthline has made every effort to make certain that all information is factually correct, comprehensive, and up to date. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. You should always consult your doctor or another healthcare professional before taking any medication. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses. Common and Mild Side Effects of Veozah: Abdominal pain Diarrhea Insomnia (difficulty sleeping) Back pain Hot flashes Serious Side Effects of Veozah: Elevated liver enzymes Allergic reactions that can lead to life-threatening symptoms such as swollen face, lips, or tongue, difficulty breathing, or wheezing. In severe cases, may require hospitalization. Veozah does not cause weight gain or weight loss. The information above also indicates some contraindications, including: 1. Cirrhosis (severe liver scarring) 2. Severe renal (kidney) problems, including end-stage kidney disease (ESRD) 3. Taking drugs that block the enzyme CYP1A2, such as ciprofloxacin (Cipro) and fluvoxamine (Luvox) ### ‍What ‌Are the Common Side Effects of Veozah? Veozah, like many medications, can cause side effects. Common side effects may include nausea, headache, dizziness, and fatigue. These symptoms are ‍generally mild and often resolve⁣ on their own as your body ‌adjusts to the medication. ### How ⁢Can ⁤I Manage Nausea⁢ From Veozah? To manage nausea caused by Veozah, try eating small, frequent meals throughout the day and avoid rich, spicy, or fatty foods. Staying‍ hydrated ‌and drinking ginger tea might also help alleviate nausea. ### Is Dizziness a Serious Side Effect of Veozah? Dizziness is a known side⁣ effect⁢ of Veozah but‍ is usually not serious. If you experience dizziness, ⁢try ‌sitting ⁣or lying down until it passes, and avoid ⁢driving or operating heavy machinery. ### What Should ‍I Do⁢ If I Experience a Severe Headache⁤ on Veozah? If you have a severe headache while taking Veozah, it's important to rest and stay hydrated. Over-the-counter pain relievers may help, but consult your doctor if headaches persist or become too severe. ### Can Fatigue From Veozah Affect My Daily Activities? Fatigue is a possible side effect⁢ of Veozah and ⁢can affect daily activities. Ensure you're getting enough

rest, maintain a balanced diet, and engage in light exercise to boost ⁢your energy levels. ### When Should I Contact My Doctor About Veozah Side Effects? Contact your doctor if side effects are ‍severe, ‍persist for an extended period, or ⁣cause significant discomfort. Immediate⁤ medical attention⁣ is necessary if you experience symptoms like chest pain, difficulty breathing, or severe allergic reactions. ### Are There Long-Term‌ Side Effects of Veozah? Currently, there is limited information on the long-term side effects of ‌Veozah. It's important to have regular consultations with ⁢your⁢ healthcare provider to⁢ monitor your health while⁤ on medication. ### Can Lifestyle Changes Help⁢ Minimize Veozah Side Effects? Yes, lifestyle changes such as a balanced ⁢diet, regular exercise, ⁢and adequate hydration can help minimize‌ some side effects of‌ Veozah.⁢ Always discuss with your healthcare provider any⁣ lifestyle strategies‌ you plan to implement.

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menoplus0 · 21 days

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Natural Supplements for Managing Menopause: A Comprehensive Guide

Black Cohosh

Black cohosh is one of the most well-known herbal remedies for menopausal symptoms. It has been used for centuries by Native Americans to treat a variety of female reproductive issues, including menstrual cramps and hot flashes. Research shows that black cohosh may help reduce the severity and frequency of hot flashes, night sweats, and other vasomotor symptoms associated with menopause. Additionally, it may have a mild effect on mood, helping to alleviate anxiety and depression in some women.

Red Clover

Red clover is a plant that contains isoflavones, compounds that mimic estrogen in the body. These plant-based estrogens may help regulate hormone levels and reduce menopausal symptoms like hot flashes, bone density loss, and cardiovascular issues. Red clover is often recommended for women who want to avoid hormone replacement therapy but still seek relief from estrogen-related symptoms.

Maca Root

Maca root, a plant native to the high Andes of Peru, Menopause Natural Supplements has gained popularity as a natural remedy for balancing hormones during menopause. Rich in essential nutrients like vitamins, minerals, and amino acids, maca root is believed to support the endocrine system, helping to regulate hormone production. Women who take maca root may experience reduced hot flashes, improved energy levels, and enhanced libido. Additionally, maca may improve mood and reduce feelings of anxiety and depression, which are often prevalent during menopause.

Flaxseed

Flaxseed is a rich source of lignans, which are plant compounds that have weak estrogenic properties. These lignans may help balance hormone levels and provide relief from hot flashes and night sweats. Flaxseed is also high in omega-3 fatty acids, which can support heart health—a major concern for postmenopausal women. Adding ground flaxseed to your diet or taking flaxseed oil supplements can help support overall well-being during menopause.

Vitamin D and Calcium

As women go through menopause, Dry Vaginal Cream the decline in estrogen can lead to decreased bone density and a higher risk of osteoporosis. To maintain strong bones, it's important to ensure adequate intake of vitamin D and calcium. Vitamin D helps the body absorb calcium, while calcium itself is essential for maintaining bone strength. These supplements, when taken together, can help prevent bone loss and reduce the risk of fractures as you age.

Evening Primrose Oil

Evening primrose oil is another popular supplement for menopausal women. It contains gamma-linolenic acid (GLA), an omega-6 fatty acid that may help reduce inflammation and promote hormonal balance. Women who take evening primrose oil may experience relief from breast tenderness, mood swings, and hot flashes.

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examexpert · 29 days

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Chapter 61 Estrogens and Progestins: Basic Pharmacology and Noncontraceptive Applications

Chapter 61 Estrogens and Progestins: Basic Pharmacology and Noncontraceptive Applications Complete Chapter Questions And Answers Sample Questions MULTIPLE CHOICE 1. A 50-year-old postmenopausal patient who has had a hysterectomy has moderate to severe vasomotor symptoms and is discussing estrogen therapy (ET) with the nurse. The patient is concerned about adverse effects of ET. The nurse…

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delveinsight12 · 2 months

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Hot Flashes Market expected to rise | Companies- Veru Healthcare, Fervent Pharmaceuticals, Ogeda, Bayer, Lundbeck A/S, TherapeuticsMD, MenoGeniX, Mitsubishi Tanabe Pharma, QUE Oncology, Pherin Pharmaceuticals, expected to drive market

The Hot Flashes market growth is driven by factors like increase in the prevalence of Hot Flashes, investments in research and development, entry of emerging therapies during the study period 2019-2032.

The Hot Flashes market report also offers comprehensive insights into the Hot Flashes market size, share, Hot Flashes epidemiology, emerging therapies, market drivers and barriers, ongoing clinical trials, key collaboration in the space, market uptake by key therapies and companies actively pushing Hot Flashes market size growth forward.

Some of the key highlights from the Hot Flashes Market Insights Report:

Several key pharmaceutical companies, including Veru Healthcare, Fervent Pharmaceuticals, Ogeda, Bayer, Lundbeck A/S, TherapeuticsMD, MenoGeniX, Mitsubishi Tanabe Pharma, QUE Oncology, Pherin Pharmaceuticals, and others, are developing novel products to improve the Hot Flashes treatment outlook.

The total Hot Flashes market size will include the market size of the potential upcoming therapies and current treatment regimens in the seven major markets.

As per DelveInsight analysis, the Hot Flashes market is anticipated to witness growth at a considerable CAGR

Strategise your business goals by understanding market dynamics @ Hot Flashes Market Landscape

Hot Flashes Overview

Hot flashes (HFs) are a rapid and exaggerated heat dissipation response, consisting of profuse sweating, peripheral vasodilation, and feelings of intense, internal heat. They are triggered by small elevations in core body temperature (Tc) acting within a greatly reduced thermoneutral zone, i.e., the Tc region between the upper (sweating) and lower (shivering) thresholds.

Hot flashes (HFs) are the most common symptom of the climacteric and are reported as feelings of intense warmth along with sweating, flushing, and chills. More than 80% of women experience hot flashes (HFs) during menopause. Defined by transient sensations of heat, sweating, flushing, anxiety, and chills lasting for 1–5 min, HFs can cause considerable distress especially when severe and frequent.

Among various factors reported to be associated with increase in incidence of HFs, a consistent association has been found only with obesity, African descent, lower socioeconomic status, presence of premenstrual syndrome, sedentary lifestyle, and smoking. HFs are characterized by excessive vasodilation of peripheral vasculature to lose heat in the setting of abnormal hypothalamic thermoneutral zone. While normal women initiate mechanisms of heat loss, once core body temperature increases by 0.4°C, women with HFs initiate vasodilatory response with a much smaller increase in core body temperature. It is peripheral vasodilatory response that results in profuse sweating and sensation of intense heat.

Do you know the treatment paradigms for different countries? Download our Hot Flashes Market Sample Report

Recent Highlights from the Hot Flashes Market Report:

In April, Fervent Pharmaceuticals has initiated a virtual at home Phase II clinical trial of its new product to treat the symptoms of moderate to severe hot flashes, night sweats and night-time awakenings due to hot flashes in women. Named M2S Hot Flash Study, the trial will analyse the peri- and post-menopausal therapy to treat hot flashes and night sweats.

In January 2020, Veru Inc, developing novel medicines for the management of prostate cancer, today announced positive top line data interim results from its Phase 2 clinical study of Zuclomiphene citrate, a nonsteroidal oral estrogen receptor agonist, for the treatment of androgen deprivation hormone therapy (ADT) induced hot flashes, also known as vasomotor symptoms, in men who have advanced prostate cancer. Zuclomiphene appears to be well tolerated as there have been no reports of drug related serious adverse events nor drug related severe adverse events and no observations of adverse events of special interest, such as breast enlargement or pain, or venothromboembolic events (blood clots in legs or lungs, or stroke) in the safety database for the Phase 2 clinical study.

Hot Flashes Epidemiology Segmentation

DelveInsight’s Hot Flashes market report is prepared on the basis of epidemiology model. It offers comprehensive insights to the Hot Flashes historical patient pools and forecasted Hot Flashes patients. The report provides in-depth data of various subtypes and for the same epidemiology is segmented further. The Hot Flashes Market report proffers epidemiological analysis for the study period 2019-32 in the 7MM segmented into:

Hot Flashes Prevalence

Age-Specific Hot Flashes Prevalence

Gender-Specific Hot Flashes Prevalence

Diagnosed and Treatable Cases of Hot Flashes

Visit for more @ Hot Flashes Epidemiological Insights

Hot Flashes Treatment Market

The Hot Flashes market outlook of the report helps to build a detailed comprehension of the historic, current, and forecasted Hot Flashes market trends by analyzing the impact of current Hot Flashes therapies on the market, unmet needs, drivers and barriers, and demand for better technology.

This segment gives a thorough detail of Hot Flashes market trend of each marketed drug and late-stage pipeline therapy by evaluating their impact based on the annual cost of therapy, inclusion and exclusion criteria, mechanism of action, compliance rate, growing need of the market, increasing patient pool, covered patient segment, expected launch year, competition with other therapies, brand value, their impact on the market and view of the key opinion leaders. The calculated Hot Flashes market data are presented with relevant tables and graphs to give a clear view of the market at first sight.

According to DelveInsight, the Hot Flashes market in 7MM is expected to witness a major change in the study period 2019-2032.

Hot Flashes Emerging Drugs

Fezolinetant: Astellas Pharma

Fezolinetant is an investigational selective neurokinin-3 (NK3) receptor antagonist. The safety and efficacy of fezolinetant are under investigation and have not been established. If approved by regulatory authorities, fezolinetant would be a first-in-class, nonhormonal treatment option to reduce the frequency and severity of VMS associated with menopause.

Elinzanetant: Bayer

Elinzanetant is a first-in-class, non-hormonal, orally administered, dual neurokinin-1,3 receptor antagonist currently in clinical development for the treatment of vasomotor symptoms during menopause. Elinzanetant addresses vasomotor symptoms by modulating a group of oestrogen sensitive neurons in the hypothalamus in the brain (the KNDy neurons), that due to the absence of oestrogen, become hyperactive in menopausal women and consequently disrupt body heat control mechanisms resulting in the debilitating vasomotor symptoms of hot flashes.

Fezolinetant: Ogeda

Fezolinetant (ESN364) is a proprietary, oral, small-molecule, discovered and developed by Ogeda for the purpose of the treatment of women’s health disorders. Fezolinetant’s mechanism of action to mimic the neuronal effects of estrogen to control body temperature supports the use of fezolinetant to directly and safely address the basis for hot flashes in menopausal women. In addition, fezolinetant addresses the cause of PCOS by selectively lowering luteinizing hormone (LH) without affecting follicle-stimulating hormone (FSH) in order to restore the correct LH-to-FSH ratio and permit the restoration of menstrual cycle regularity and fertility. Fezolinetant is also superior to the existing, marketed gonadotropin-releasing hormone (GnRH) ligands as it reduces levels of the ovarian hormones estrogen and progesterone in a non-castrating manner as required for the safe, effective treatment of uterine fibroids and endometriosis.

Zuclomiphene citrate: Veru Inc

Zuclomiphene citrate is a novel, proprietary, oral, nonsteroidal, estrogen receptor agonist. Today the Company announced that a Phase 2 clinical trial of Zuclomiphene citrate demonstrated a statistically significant reduction in the frequency of moderate to severe hot flashes in men with advanced prostate cancer on ADT therapy.

Hot Flashes Key Companies

Veru Healthcare

Fervent Pharmaceuticals

Ogeda

Bayer

Lundbeck A/S

TherapeuticsMD

MenoGeniX

Mitsubishi Tanabe Pharma

QUE Oncology

Pherin Pharmaceuticals

For more information, visit Hot Flashes Market Analysis, Patient Pool, and Emerging Therapies

Trending Reports by DelveInsight:

About DelveInsight:

DelveInsight is a prominent business consultant and market research firm specializing in the life sciences sector. With a focus on supporting pharmaceutical companies, DelveInsight provides end-to-end solutions to enhance their performance.

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Kritika RehaniTeam Lead, Marketing

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healthcarehubhh · 2 months

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The Rise of Serotonin Norepinephrine Inhibitor Antidepressants

SNRIs work by increasing the levels of the neurotransmitters serotonin and norepinephrine in the brain. Serotonin and norepinephrine are naturally occurring chemicals in the brain that play important roles in mood regulation. Low levels of these neurotransmitters have been linked to depression. SNRIs work by blocking the reabsorption (reuptake) of serotonin and norepinephrine back into neurons after they have been released. This allows the neurotransmitters to stay in the synapse longer, improving communication between neurons. Common SNRIs prescribed include duloxetine (Cymbalta), venlafaxine (Effexor), and desvenlafaxine (Pristiq). Effectiveness against depression Numerous clinical trials have shown SNRIs to be effective for treating major depressive disorder. While selective serotonin reuptake inhibitors (SSRIs) were previously the most commonly prescribed first-line treatment for depression, SNRIs are gaining popularity due to the belief that they may work better for certain types of depression. Studies have found SNRIs to be equally or more effective than SSRIs for conditions like chronic depression, depression associated with anxiety disorders, and depression accompanied by physical symptoms like pain. SNRIs may provide a faster onset of action and higher remission rates than SSRIs in some cases. Growing use despite higher cost While SNRIs do not have generic versions available yet in the US, insurance coverage and use has significantly expanded in recent years. SNRIs are often more expensive than generic SSRIs and may cost two to four times as much for a month's supply. However, this higher upfront cost is outweighed for insurers if the person achieves remission faster and avoids more expensive care down the line, such as additional medications, therapy, or hospitalization. As a result, many insurance plans have placed SNRIs on lower cost-sharing tiers to encourage their use over SSRIs when clinically appropriate. As patents on branded SNRIs expire in the next few years, the availability of lower-cost generics may push use of these drugs even higher. Expanded indications beyond depression Originally developed and approved for the treatment of major depressive disorder, SNRIs are now routinely prescribed for other conditions due to their dual action on serotonin and norepinephrine. Some common "off-label" uses of SNRIs include: - Generalized anxiety disorder: SNRIs can reduce physiological symptoms like chronic muscle tension as well as excessive worries. - Social anxiety disorder: SNRIs may improve symptoms of anxiety experienced in social situations and performance venues. - Panic disorder: SNRIs are a first-line treatment option for reducing panic attacks and anticipatory anxiety. - Chronic pain conditions: The pain-relieving effects of SNRIs have made them a standard treatment for fibromyalgia, diabetic neuropathy, arthritis, and other forms of chronic musculoskeletal pain. - PTSD: SNRIs can lessen core symptoms of post-traumatic stress disorder like flashbacks, nightmares, and hyperarousal. - Menopausal symptoms: SNRIs are commonly prescribed off-label for hot flashes, mood swings, and other vasomotor symptoms of menopause. Side effects are treatment-limiting for some While generally well-tolerated, serotonin norepinephrine inhibitors do commonly cause mild to moderate side effects, at least initially, in many people. Common adverse events reported include nausea, headache, insomnia, drowsiness, fatigue, sexual dysfunction, and constipation or diarrhea. For some individuals, side effects may be severe enough to warrant changing medications or discontinuing treatment altogether. SNRIs also carry boxed warnings for potential increased suicidal thoughts in children, adolescents, and young adults. Careful symptom monitoring during the first few months of treatment is recommended. However, for many patients the benefits of SNRIs outweigh these potential risks.

#Serotonin Norepinephrine Inhibitors Trend #Serotonin Norepinephrine Inhibitors Growth #Serotonin Norepinephrine Inhibitors Share

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