#subacute (sspe)

[fidicusraredisease]

Call : +917997101303 | Whatsapp : https://wa.me/917997101505 | Website : https://fidicus.com

Precautions, neglect Complications SSPE, Subacute Sclerosing Panencephalitis | Treatment Cure Relief | Rare Orphan Unique Disease | Dr. Bharadwaz

Speciality Clinic

Fidicus Rare Disease

highest success with homeopathy

Any Disease | Any Patient | Any Stage

About Video : Diving into SSPE, let's navigate through essential precautions and prognosis means what happens when you neglect this disease. Explore crucial steps to safeguard against SSPE, understanding the disease's trajectory and potential outcomes. Gain insights into preventive measures, prognosis factors, and proactive approaches for managing this challenging condition. Empower yourself with knowledge for a better understanding of SSPE's journey.

[teachingrounds]

Q. What are the possible complications from measles (rubeola)?

A. According to the CDC, complications from measles infection include

- hospitalization (1:5 unvaccinated individuals) - otitis media (1:10) - pneumonia (1:20) - encephalitis (1:1000) - death (1-3:1000) - subacute sclerosing panencephalitis (SSPE) is a delayed neurodegenerative disorder of personality changes, seizures, coma, and death ~10-11 years after infection

[willowreader]

I had the measles in 1959 at the age of 7. I was in a dark room for 2 weeks to help prevent me from going blind. I was very sick. My mom had 3 other children. A 4 year old and 10 month old twins. Kids in Canada were dying. She was terrified. 1 to 2 children in 1000 will die of measles if not vaccinated. There are complications like immune system damage and measle encephalitis. It can also lead to a neurological disease called SSPE that can kill a child years later. Today I read a post from a young mother who has decided that her children have a strong enough immune system to handle measles. My god I feel like screaming. We have good science. We fixed this year's ago. Please listen to us old people who experienced this. Children will die.

This author's daughter died of measles. Read the story and then vaccinate your children if they are not vaccinated for this horrible disease.

[alicesara611]

Inosine Pranobex Market Forecast: 5-Year Outlook By 2023 to 2028

The global inosine pranobex market is expected to reach US$ 234.5 million by 2028, growing at a CAGR of 2.2%. The growth of the market is attributed to the increasing prevalence of respiratory diseases, such as chronic obstructive pulmonary disease (COPD), asthma, and influenza. Inosine pranobex is a drug that has been shown to be effective in the treatment of these diseases.

Inosine pranobex (IP) is an antiviral and immunomodulatory drug used to treat a variety of viral infections, including subacute sclerosing panencephalitis (SSPE), herpes simplex virus (HSV), human immunodeficiency virus (HIV), human papillomavirus (HPV), influenza, and acute respiratory infections. IP is available in tablet and syrup form.

Discover Our Expert Analysis with Our Sample Report! https://absolutemarketresearch.com/Global-Inosine-Pranobex-Market/2037/request-sample

Inosine Pranobex is an antiviral medication used to treat respiratory infections, including the common cold and the flu. It is also used to prevent respiratory infections in people who are at high risk. Inosine Pranobex is not a cure for the common cold or the flu, but it can help to shorten the duration of the illness and reduce the severity of symptoms.

Key Takeaways:

The global inosine pranobex market is expected to reach US$ 234.5 million by 2028, growing at a CAGR of 2.2%.

The market is driven by the increasing prevalence of viral infections and the growing demand for immunomodulators.

Asia Pacific is expected to be the fastest-growing regional market, due to the large and growing population and the rising prevalence of viral infections.

The tablets segment is expected to be the largest segment of the market, due to their ease of use and convenience.

Regional Outlook:

North America: The North American inosine pranobex market is expected to grow at a CAGR of 1.5% from 2023 to 2028.

Europe: The European inosine pranobex market is expected to grow at a CAGR of 2.0% from 2023 to 2028.

Asia Pacific: The Asia Pacific inosine pranobex market is expected to grow at a CAGR of 3.0% from 2023 to 2028.

South and Central America: The South and Central American inosine pranobex market is expected to grow at a CAGR of 2.5% from 2023 to 2028.

Key Players:

Newport Pharmaceuticals

Gedeon Richter

Mochida

Sanofi-Aventis

Yung Shin

Sigma-Tau

Polfarmex

Sanfer

Meprofarm

Novell Pharmaceutical

Aflofarm

Market Segmentation:

The inosine pranobex market is segmented by type, application, and geography.

Type:

Tablets

Syrup

Application:

Immunomodulation

Antiviral applications

Others

Geography:

North America

Europe

Asia Pacific

South and Central America

[terrie01]

The most common cause of death from measles is pneumonia, and I genuinely hope if there are any deaths, that's what causes them. Because one thankfully rare way measles can kill is called subacute sclerosing panencephalitis. It happens years after the original infection, and causes neurological deterioration over 1-3 years, ending in death. Some studies suggest that in infants too young to be vaccinated, the rate could be as high as 1 in 625 cases. I can't tell you how much I hope we never see a single case of SSPE as a result of this madness.

They are going to kill some kids, aren't they?

[5minpediatrics]

Subacute Sclerosing Panencephalitis (SSPE): Unraveling the 9S Mnemonics for Diagnosis and Management

Subacute Sclerosing Panencephalitis (SSPE):mnemonics     Introduction:Subacute Sclerosing Panencephalitis (SSPE) is a rare and devastating neurological disorder caused by a persistent infection of the measles virus. This article aims to provide a comprehensive overview of SSPE, focusing on the 9S mnemonics as a tool for understanding its pathogenesis, clinical presentation, and supportive��

[itsdoctorhouse]

Paternity

CC: Diplopia, night terrors ongoing 3 weeks, and a myoclonic jerk

Dx: Subacute sclerosing panencephalitis (SSPE)

Diplopia:

aka double vision: the perception of two images instead of a single object

Common causes usually stem from issues with the eyes, muscles and nerves controlling the eyes, and the brain.

Night terrors:

As mentioned in the episode, there are two leading causes for onset teenage night terrors: PTSD and sexual abuse.

Personally I think there isn’t much reason for the patient to have experienced night terrors beyond the initial stages of SSPE causing changes in emotional behavior and personality.

Myoclonic jerk:

Brief, involuntary twitching of some muscles; generally in healthy persons it can be seen right before falling asleep (aka a hypnic jerk).

The patient presents it even though he’s not asleep or tired.

Multiple sclerosis (MS):

In the episode:

After testing some CSF, because of a buildup and blockage, they find high levels of IgG and assume multiple sclerosis, but find no evidence of lesions. A good assumption because over 80% of patients with MS show oligoclonal bands with high IgG.

Since the patients symptoms have only begun 3 weeks previously they determine it’s rapidly progressive MS.

They can’t definitively diagnose MS, because there are no specific tests for it. Generally doctors have to rule out every other possibility before they can confirm. What’s mentioned in the episode is waiting 6 months to confirm, most likely to see progression of symptoms as well as ruling out differentials.

More on Marburg MS s7e08 “Small Sacrifices”

MS is a chronic central nervous system disease in which the myelin sheath and nerve axons in the brain are destroyed. It’s referred to as a demyelinating disease. The damage disrupts the ability to transmit signals which can result in a slew of signs and symptoms.

The three main characteristics are the formation of lesions/plaques in the CNS, inflammation and the destruction of myelin sheaths of neurons

Other specific symptoms usually include diplopia, blindness in one eye, muscle weakness, and trouble with sensation or coordination.

Some pathognomonic signs include:

Internuclear ophthalmoplegia (INO): an impairment in the lateral conjugate gaze, meaning that when both eyes are looking toward one side the affected eye cannot properly adduct (move toward the center). Caused bye a lesion in the medial longitudinal fasciculus (part in the brainstem).

To put it simply, if the right eye is affected, the patient should be able to look to the right, and cross their eyes, but upon looking to the left, the right eye won’t be able to move to the midline.

Positive Romberg’s sign: when the patient sways or falls with their eyes closed. It demonstrates a loss of postural control and proprioception (perception and awareness of one’s body) in the absence of visual input.

Positive Lhermitte’s sign: paresthesia/an electrical shock that passes down the back of the neck and spine, usually brought upon by bending the head forwards towards the chest.

Progression usually occurs as episodes of worsening lasting days to months, followed by improvement (relapsing episodes).

Subacute sclerosing panencephalitis (SSPE):

Early in the episode Cameron admits to not having taken a full history or family history which really would have solved the case a hell of a lot sooner, given his birth mother was the cause of the patients issues.

tbf, it was the whole point of the episode to focus on determining paternity, which, given all the daddy issues on the show is a good setup.

Then again, the patient is a 16 year old lacrosse player, and he figured out he was adopted at a much younger age, 10 if I remember right, just from having a cleft chin. Talk about selective blindness on the team.

aka Dawson disease

SSPE is a super rare complication from measles wherein there is chronic progressive brain inflammation caused by the mutated virus.

Patients generally have history of a primary measles infection in infancy (where the birth mother was not vaccinated and thus could not pass along the proper antibodies to protect the infant for up to 6 months), followed by an asymptomatic period that can last up to 27 years. Afterwards neurological deterioration ensues with behavioral changes, myoclonic seizures, visual disturbances, ataxia, and ultimately death.

Anti-measles IgG appears to increase as the disease progresses

There is no definitive cure, but if it is diagnosed in the first stage of the disease oral isoprinosine and intraventricular interferon alfa could help, it varies patient to patient. And the only accepted treatment are purely supportive: anticonvulsants.

Should not be confused with acute disseminated encephalomyelitis (ADEM), which can also be caused by the measles virus.

Another demyelinating disease, it is a rare autoimmune disease with acute inflammation of the brain and spinal cord.

Often triggered by a viral infection or specific non-routine vaccinations.

Very closely resembles symptoms of MS except for usually occurring in children and marked with rapid fever.

[mcatmemoranda]

SSPE = Subacute Sclerosing Panencephalitis. It's a possible sequela to measles that can occur years after the measles resolves.

[sarcasticcynic]

Reminder: The United States completely eliminated measles almost twenty years ago. Outbreaks occurred only “via travelers coming from countries where measles is still common.”

“The virus has spread among school-age children whose parents declined to give them the vaccine, which confers immunity to the disease. A vocal fringe of U.S. parents cite concerns the vaccine may cause autism, despite scientific studies that have debunked such claims. ... 72% of the people infected with measles were unvaccinated. Of the others, 10% had at one of the two recommended vaccine doses, while the status of the remaining 18% was unclear.”

Reminder: Measles is not just an uncomfortable rash.

“Measles can be dangerous, especially for babies and young children. From 2001-2013, 28% of children younger than 5 years old who had measles had to be treated in the hospital.”

Measles can lead to:

Pneumonia (a “serious lung infection”)

Deafness

Lifelong brain damage

And yes, even death (“Measles kills about 1 in 1,000 who get it”)

“Measles is highly contagious and not always a transient illness -- it can have serious complications and even prove fatal. ... These include pneumonia as well as encephalitis, which causes the brain to swell. A case in point is the 43-year-old Israeli flight attendant for El Al who remains in a coma after catching the measles and developing encephalitis. ... When children under age 2 get the measles, an inflammation of the brain called subacute sclerosing panencephalitis (SSPE) can develop five to 10 years later. ... SSPE can cause seizures, blindness, paralysis and eventually, a persistent vegetative state and death.”

[fidicusraredisease]

Call : +917997101303 | Whatsapp : https://wa.me/917997101505 | Website : https://fidicus.com

Treatment For SSPE, Subacute Sclerosing Panencephalitis, Dowson Disease | Homeopathy Treatment Cure Relief | Rare Orphan Unique Disease | Dr. Bharadwaz

Speciality Clinic

Fidicus Rare Disease

highest success with homeopathy

Any Disease | Any Patient | Any Stage

About Video : "Exploring SSPE treatment options? Dive into the debate between conventional medicine's limitations and homeopathy's promises. Discover how conventional treatments for SSPE often fall short, leading to symptoms' persistence. Contrastingly, homeopathy's holistic approach and personalized remedies offer potential advantages, aiming for long-term relief. Uncover the pros and cons to make informed health decisions!"

[garethprice-blog1]

The Off-Switch for a Ticking Time-Bomb: The Importance of the Measles Vaccine

The pattern is clear: over the last decade or so vaccination uptake globally has dramatically declined, and cases of measles and other illnesses commonly vaccinated against during childhood has dramatically increased.

This is a pattern that is also being seen in the UK. A recent report by Unicef and the World Health Organization (WHO) found that between 2010 and 2017, 527,000 children in the UK who were eligible to receive their vaccinations were not vaccinated. This has led to spikes in cases of measles in certain parts of the country – ‘Public Health England (PHE) said there had been 47 cases across Greater Manchester in 2019, compared to only three cases in 2018 and seven in 2017’ (https://www.bbc.co.uk/news/uk-england-manchester-48040787). The issue has recently been described as ‘a ticking time-bomb’ by the NHS chief Simon Stevens: https://www.bbc.co.uk/news/health-48039524.

The accepted cause for these patterns is growing concerns some parents have concerning vaccinations and the effects they have on their children. It’s worth saying at this point that I am about to start working as a doctor within the NHS and I passionately believe in the vital role vaccination plays in public health. Because of this, I have decided to make this short little piece to try and answer some of the most common questions and concerns some parents have regarding vaccines. These questions are the ones I have seen most commonly being asked during my clinical placements in hospitals and GP practices, as well as on the internet and social media. I have tried to reference all the answers to show that they’re not just my wild imaginings and are all backed up by thorough evidence and research.

If you’ve ever felt concerned or sceptical about vaccinations, if you have seen or read anti-vaccination literature in the past, or if you are just curious, please just give this a read and let me know what you think.

Do vaccinations even work?

Yes. Numerous studies by various organisations worldwide, including WHO, have shown that vaccinations are secondary only to clean water in reducing the burden of disease on a population (https://www.who.int/bulletin/volumes/86/2/07-040089/en/). As long as the uptake rate is high enough, vaccination can dramatically reduce the incidence of its target disease, and in some cases even eliminate it from the population. This occurs through an effect known as ‘herd immunity’ – this means as long as enough of the population take up the vaccine – around 90-95% for measles – so many people are immune to the virus that it can no longer survive in that community. This elimination of a disease has actually been achieved in some instances, such as the eradication of smallpox in 1980 through a vaccination programme. Local elimination of measles has also been seen in areas with high uptake of the measles vaccine e.g. in Finland. https://www.who.int/bulletin/volumes/86/2/07-040089/en/

How do vaccines work?

To understand how vaccines work, its first best to get an idea of how our body fights an infection. When exposed to a bacteria or virus, our body can quickly become a battlefield. Our body puts up a whole host of defences to try and stop the bacteria or virus spreading throughout the body. Some of these defences include increasing body temperature to try and burn off the infection (this is why we get fevers) or even just trying to cough or sneeze up the bacteria or virus in snot or mucous.

Our soldiers in this battlefield are called white blood cells. A specific type of white blood cell called a B cell can learn to recognise certain shapes on the cell of the infecting organism that are unique to that bacteria or virus – just like people have their own distinctive looks and facial features that help you recognise them. Once it realizes this, the cell makes many clones of itself so that next time that same bacteria or virus attacks the body, it can quickly be recognised and all your body’s defences can attack and destroy it, usually before you even start to feel ill.

Vaccines work in the same way. Vaccines contains a little bit of this unique bacteria/virus shape and allows your body to see it, recognise it as an invader and then memorise it. This means that if your body ever gets infected with the real deal, your body will recognise it quickly and be able to destroy it before you even start to feel ill. Some vaccines contain just this little shape, while others contain dead or deactivated versions of the virus or bacteria which cannot cause true infection but still allow your body to learn its unique shape. The measles vaccine contains a weakened, also known as attenuated, form of the virus.

This video explains the process pretty well too: https://www.youtube.com/watch?v=-muIoWofsCE

Isn’t measles just like a bad case of the flu? Does my child really need to be vaccinated?

Widespread vaccination programmes are still a relatively recent thing (the first vaccine against measles in the UK was introduced in 1968). Despite this, the programme has been so effective that measles became a forgotten disease that we didn’t see anymore and only the older generation could remember.

Public Health England

http://vk.ovg.ox.ac.uk/measles

Measles is a lot worse than a bad case of the flu. Children who develop measles at first develop fever, greyish-white spots in the mouth and a distinctive red-brown rash that starts behind the ears before spreading to the rest of the body. Children are usually unable to get out of bed for around five days and can miss up to two weeks of school. The initial infection often also leads to complications such as further infections in the ear, lung or even the brain.

But beyond these usual cases, in a minority of children infected with measles, the disease can be fatal. It is thought that one out of every 5000 children infected with measles will die. The famous children’s author Roald Dahl’s daughter died of a complication of measles and he spent much of his life after her death campaigning and spreading the word about the importance of vaccination in the fight against measles and other infections. You can read his account of his daughter’s death and the effect it had on him here: http://vk.ovg.ox.ac.uk/blogs/ojohn/how-dangerous-measles).

In a small number of cases, some children infected with measles go on to develop a condition called subacute sclerosing panencephalitis (SSPE). The children often don’t develop the condition until years after their initial measles infection. Its caused by the measles virus spreading to the brain, leading to destruction of the central nervous system, dementia, epilepsy and eventually death. You can watch a video on the effect SSPE has had on a family’s life here: https://www.youtube.com/watch?v=aB8kGwKZiq0

If everyone else is vaccinated, does it really matter if my child doesn’t get the vaccine?

As explained earlier, eliminating a virus or bacteria from a community is dependant on the effect of herd immunity. For the measles virus, it has been calculated that around 90-95% uptake is needed to provide effective protection against the virus for the population. There are a number of children who, for many reasons, will not be able to receive the vaccine. These reasons include them being too young to receive the vaccine (the vaccine against measles is usually given at around 1 year of age) or if the child has other illnesses e.g. cancer, that mean its immune system is not able to mount an effective immune response to the vaccine.

This means that if healthy children are not vaccinated, they may carry the virus and spread it to children who are not able to receive the vaccine. If a healthy unvaccinated child gets infected with measles they will likely be able to fight off the infection themselves but may inadvertently spread it to children who are not strong enough to fight the infection. In these children, the risk of developing complications and severe infections is much more likely and so it is very important for all children who can be vaccinated to be vaccinated in order to protect everyone.

Don’t vaccinations cause autism?

No. This controversy was started after a paper was published in the medical journal the Lancet in 1998 claiming that there was a link between children who received the MMR (measles, mumps and rubella) vaccine and children who went on to develop developmental disorders such as autism spectrum disorder. The claims made in the paper were quickly picked up by the national press and led to a widespread distrust of vaccinations that is still felt in some areas of the UK and the world today.

Due to the seriousness of the claims and the panic it caused, a vast amount of time and money went into research looking into the link. They all reached the same conclusion: there is no link between the MMR vaccine and autism. They also found that Andrew Wakefield’s study had been seriously flawed:

1)    Wakefield selected patients that had already started to show signs of autism before his study began, meaning his study wouldn’t be a fair reflection on the effect of the MMR vaccine on the general population.

2)    Wakefield falsified the information to suit the results he wanted to get e.g. one child in the study had already started to show some signs of autism before receiving his MMR vaccine (this was clearly stated in the child’s medical records), but in Wakefield’s report it stated that the first signs appeared months after the vaccination

3)    Wakefield was being paid to conduct the research by lawyers representing parents who were against vaccines. This meant that he was set to gain financially if he could discredit the safety of vaccinations.

The man behind the now disgraced report linking the MMR vaccine to autism; Andrew Wakefield

For all these reasons, the Lancet retracted the paper and Andrew Wakefield was later found guilty of deliberate fraud and struck off from the medical register, although he still has a large following in some parts of the world, particularly in the anti-vaccination community. Due to the amount of research that went into investigating the link between the MMR vaccine and autism at the time, the fact that there is no link between the two is now one of the most well-proven things in modern medicine.

You can find more in-depth information on why Wakefield’s paper was fraudulent and unreliable here: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3136032/ and https://www.bmj.com/content/342/bmj.c7452. And more information on research into the link between the MMR vaccine and autism can be found at the bottom of this page ‘Is The Vaccine Safe?’: http://vk.ovg.ox.ac.uk/mmr-vaccine

Could my child get ill from the vaccine?

Because a vaccine is trying to trick the body into thinking that there is an infection starting, the body can sometimes switch on all its defences after a vaccine e.g. fevers, runny noses. This occurs in around 1 in 10 children who receive the vaccine and normally wears off after 2-3 days. Another common side effect is redness and some pain and swelling around the site of the injection, which again quickly wears off.

In a small number of cases (1 in 1000), some children can develop fits or seizures following the vaccine. Although this is a serious side effect and will need medical attention, it is worth remembering that fits and seizures are far more common in child infected with the real measles virus.

Some parents also voice concerns regarding allergy to the measles vaccine, particularly regarding children with egg allergies. Although the measles virus strain used for the vaccine are grown on chick embryo cells there will only be tiny, if any, amounts of egg protein in the vaccine and not enough to cause an allergic reaction. Like all foods and medicines, there is a risk that a child could have an allergy to another of the ingredients of the vaccine leading to a serious allergic reaction called anaphylaxis. This kind of a reaction is extremely rare with the measles vaccine. However, this is why many healthcare professionals may want to observe the child for a few minutes following the vaccination to ensure the child doesn’t have a reaction. If a reaction does occur, the child can be quickly treated with adrenaline (the same stuff that’s used in EpiPens for people with other allergies).

If you have any concerns about your child following a vaccination, please contact your GP or other healthcare professional for more advice.

More information on the side effects of the MMR vaccine can be found at: http://vk.ovg.ox.ac.uk/mmr-vaccine

Aren’t there lots of nasty chemicals in MMR vaccine?

As well as the active ingredients needed to trigger the immune response, the MMR vaccine also contain some other ingredients that help the vaccine work:

-       Gelatine to act as a stabiliser (this is only in one form of the vaccine, a version not containing gelatine is also available)

-       Sorbitol, mannitol and recombinant human serum albumin all act as stabilisers

-       Polysorbate 80 is used as an emulsifier

-       The vaccine may also contain traces of an antibiotic called neomycin, which is used during the manufacturing process to stop bacteria growing and contaminating the culture

None of these ingredients have been shown to be harmful to humans. You can find out more information on the ingredients of the MMR vaccine at: http://vk.ovg.ox.ac.uk/mmr-vaccine

I hope you have found this piece interesting and I hope it has answered some questions you might have concerning the MMR vaccine. It is worth underlining that measles and the other infections protected against by vaccines are serious infections that are horrible to go through and can in a number of patients lead to serious complications and even death. Vaccination is vital in protecting both our healthy children and also those too young or too ill to receive the vaccination.

If you have any questions regarding the MMR vaccine or vaccines in general, please do not hesitate to contact your GP or other local healthcare professional. 

[beingjellybeans]

Protecting children’s lives through vaccines

Protecting children’s lives through vaccines

When the five-month-old son of Marissa Santos had recovered from measles, more commonly known as “tigdas,” Santos thought that that would be her son’s last encounter with the measles virus. Six years later, Santos’ son started to show symptoms of a rare and serious complication caused by measles—subacute sclerosing panencephalitis or SSPE. Santos says she hopes parents can take advantage of…

[anekasehat]

Isoprinosine, Obat untuk Infeksi yang Disebabkan oleh Virus

Isoprinosine adalah obat untuk infeksi yang disebabkan oleh virus seperti

hepatitis, herpes zoster, kutil kelamin, herpes simpleks, bronkitis, cacar, campak, gondongan, dan  influenza.

Obat antivirus ini memiliki beberapa nama lain yang lebih umum digunakan yaitu methisoprinol atau inosine pranobex.

Apa itu obat isoprinosine?

Obat isoprinosine adalah obat yang mengandung zat aktif methisoprinol.

Methisoprinol berguna untuk menambah sistem imun untuk penyakit yang disebabkan oleh virus dan menaikkan imunitas untuk kondisi kekurangan sistem imun. 

Methisoprinol adalah gabungan asam acetamidobenzoic, inosine, dan dimethylamino isopropanol.

Bagaimana cara kerja isoprinosine?

Methisoprinol tidak efektif bekerja melawan bakteri, sehingga tidak dianjurkan untuk digunakan sebagai pengobatan infeksi bakteri.

Mekanisme kerja isoprinosine ini adalah meningkatkan kondisi pasien dengan mendorong proses-proses imun yang dimediasi oleh sel untuk memerangi infeksi virus di tubuh. 

Manfaat isoprinosine

Isoprinosine (pranobex inosine atau methisoprinol) mempunyai sejumlah manfaat untuk menyembuhkan gangguan kesehatan yang disebabkan oleh virus.

Dalam dunia medis, isoprinosine digunakan untuk menangani beberapa gangguan infeksi virus berikut:

1. Infeksi virus herpes

Infeksi virus herpes simplex kerap tidak mendatangkan gejala atau luka pada awal virus menginfeksi badan.

Luka bisa bertumbuh di mana saja, namun biasanya infeksi timbul di sekitar alat kelamin, mulut, atau anus, tergantung pada jenis virusnya.

Gejala herpes lainnya dapat meliputi gatal, kesemutan, atau perih gejala seperti flu masalah buang air kecil infeksi mata.

2. Kutil kelamin

Kutil kelamin adalah gangguan kesehatan yang disebabkan oleh infeksi human papillomavirus.

Kutil kelamin timbul di permukaan kulit yang lembap terutama rektum wanita dan lubang vagina. Pada pria dan wanita, infeksi dapat muncul di area genital atau anus.

Kutil kelamin mungkin tidak memicu gejala apapun, atau dapat menyebabkan terbakar, gatal, atau nyeri.

Perawatan bergantung pada ukuran dan lokasi kutil. Obat yang dipakai untuk mengobati kutil kelamin merupakan obat oles topikal. Tapi, terkadang dokter akan memberi resep obat oral sebagai kombinasi.

Isoprinosine oral bisa diberikan sebagai terapi kombinasi dengan obat oles topikal khusus yang diperuntukkan mengobati infeksi virus.

Walaupun bukan untuk rekomendasi lini pertama, isoprinosine terbukti dapat meningkatkan efek terapi obat utama. Dengan demikian, pengobatan yang diharapkan bisa lebih efektif dan tidak membutuhkan waktu lama daripada obat topikal yang digunakan sendiri.

3. Infeksi virus tertentu di otak

Beberapa studi telah menguji khasiat isoprinosine untuk mengobati infeksi virus tertentu di otak, misalnya pada Subacute Sclerosing Panencephalitis (SSPE).

SSPE atau ahli medis mengenalnya sebagai sindrom Dawson adalah gangguan peradangan otak yang fatal efek infeksi virus campak dan persistennya pada sistem saraf serebral.

Beberapa uji klinis merekomendasikan bahwa isoprinosine bisa memberikan efek terapeutik yang bermanfaat pada pasien dengan SSPE.

Obat isoprinosine diberikan terus-menerus dengan dosis 70 mg per kilogram berat badan per hari.

Studi jangka panjang telah menguji obat isoprinosine sebagai pengobatan tunggal pada pasien SSPE. Sebagian besar penelitian melaporkan bahwa obat ini dapat meningkatkan kelangsungan hidup pasien dan menurunkan defisiensi neurologis.

4. Limfadenopati, HIV/AIDS

Sebuah analisis menunjukkan bahwa isoprinosine mampu memperbaiki sejumlah gejala klinis penyakit limfadenopati pada laki-laki yang mengalami imunosupresi.

Studi tersebut melakukan uji klinik dengan pengobatan diberikan selama 28 hari yang rupanya muncul efek klinis yang positif.

Keefektifan serta keamanan obat isoprinosine pada pasien yang terinfeksi HIV dan tanpa AIDS ditemukan aman, lantaran tidak ditemukan efek samping serius.

Pemberian obat isoprinosine mampu menurunkan perkembangan HIV menjadi AIDS. Obat ini berjalan dengan menghambat metabolisme pneumocystis jiroveci, khususnya sintesis dihidropteroat oleh asam p-acetamidobenzoic.

Beberapa peneliti juga membagikan rekomendasi pemberian obat isoprinosine dengan zidovudin mungkin mempunyai efek menguntungkan pada pasien yang terinfeksi HIV.

[srikanthfoundation]

🙏విధి అంటే తెలియని వయసులో విధాత రాసిన తన తలరాతకు వింత వ్యాధిని ఎదుర్కొంటు ప్రాణాలతో పోరాడుతుంది చిన్నారి శ్రీజ. 👉🏻కాలం ఎపుడు ఎవరిని ఎలా కాటేస్తుందో తెలియదు. అలాంటిదే జరిగింది నిజామాబాద్ జిల్లా మెండోరా మండలం, వెల్కటూర్ గ్రామానికి చెందిన పులి శ్రీజ విషయంలో. 👉🏻జరుగుతున్న కాలంలో మార్పులు ఏ రకంగా ఉంటాయో ఉహించలేము. అదే జరిగింది పాప విషయంలో. మిత్రుల సహకారంతో శ్రీజకు చికిత్స కొరకు మిత్రులు అందించిన డబ్బు వల్ల కొంచెం కొంచెం కోలుకుంటున్న దశలో కరోన విజృంభనతో lock down విధించడం, ఆ Lockdown వల్ల సమయానికి కావాల్సిన మందులు అందక పోవడం వల్ల మళ్ళీ పాప స్థితి మళ్ళీ దిగజారింది. ఎంతగా అంటే పాప మాములు చికిత్స కొరకు నిజామాబాద్ వరకు కూడా తీసుకెళ్లలేని పరిస్థితి. ప్రతిసారి nzb వెళ్ళడానికి డబ్బులు లేక వారు nzb సమీపంలో తెలిసిన వారి అందుకే మరోసారి మీకు విన్నవిద్దామని... 👩‍💼శ్రీజ ఈ పాప వయసు 9 సంవత్సరాలు వెల్కటూర్ ప్రభుత్వ పాఠశాలలో 3వ తరగతి చదువుతుంది. ఒక్కటవ తరగతి నుండి పాప చదువులో ముందుండేది. ఏమి జరిగిందో ఏమో 3వ తరగతి ప్రారంభం నుండి పాప లో చెప్పే విషయాన్ని ఏ రకంగా కూడా అర్థం చేసుకోలేని పరిస్థితికోచింది. పుస్తకం లో చూయించు ఇక్కడ రాయాలని, ఇక్కడ చూడాలి అని చెప్పిన అర్థం చేసుకోలేని స్థితి కి వచ్చింది. మరి పాప ఎందుకు ఇలా అవుతుందో డాక్టర్ కు చూయించండి అని తల్లితండ్రులకు చెప్పగా తేలిన విషయం పాపకు SSPE (subacute sclerosing pabebe phalitas )అని. సరిగా నిలబడరని పరిస్థితి ఈ వ్యాధి లక్షణాలు. నిజామాబాద్, మహారాష్ట్ర, హైద్రాబాద్ లలో చూయించారు. ఇట్టి వ్యాధికి కావాల్సిన శికిత్స పూణే లో లభిస్తుందని అందుకు ఖర్చు పెద్ద మొత్తంలో(6లక్షల వరకు) అవుతుందని డాక్టర్ లు తెలిపారు. పేద కుటుంబానికి చెందిన వీరు సహాయాన్ని అందించే ఆపన్నుల కోసం ఎదురు చూస్తున్నారు. 👉🏻ఈ విషయం తెలుసుకున్న శ్రీకాంత్ ఫౌండేషన్ వారు మానవత్వంతో స్పందించి వారికి 5,000/- రూపాయలు ఇచ్చి ధాతగా నిలిచారు. 👉🏻ఇట్టి కార్యక్రమంలో భాగంగా రామవత్ తుక్కజి నాయక్ గారు, శవ్వా శ్రీకాంత్ గారు, బచాల్వార్ నవీన్ గారు పాల్గొన్నారు. 🙏మీకు తోచినంతలో సహాయం చేయండి. దాతలు ఎవరైనా ముందుకు వచ్చి సహాయం చేసే వారు క్రింది అకౌంట్ లోకి పంపించగలరు. A/C Name : Srikanth Foundation A/C No. : 138611100002564 Bank : Andra Bank Ifsc code : ANDB0001386 Type : Current Account Branch : Bheemgal 💥 మీరు ఒక్కొక్కరు చేసే చిన్న సహాయమే పెద్ద మొత్తం కావొచ్చు. పాప ప్రాణం నిలబెట్టొచ్చు. (at Bheemgal Society) https://www.instagram.com/p/CG2UdRNLWpM/?igshid=1023f5lwe563

[roseate-rein]

You work in a bio lab? What do you think of the link between Vaccines and mental diseases like Autism? Or the people that believe in that anyway...

Hoooobuddy. Here we go. It’s time to DISPEL MYTHS ABOUT VACCINES! 

(Iknow you, anon, are not attacking me, and you do not seem like anti-vax so thisis not in response to YOU, I’m more using your ask as an opportunity to go off….)

Hello yes, Ihave a degree in biology. I’m about to go to graduate school to get a PhD in Immunology.And yes, I worked in a lab every year of college. This topic is right up myally, and I am very passionate about vaccine education! 

 Now, let’s begin withthe fact that NO STUDY HAS FOUND A LINK BETWEEN AUTISM (or any othermental conditions) AND VACCINES. 

The guy whopublished that wildly inaccurate, fudged data is Andrew Wakefield, a formergastroenterologist. His findings were investigated and found to be completelyfraudulent. Due to this, and the fact that Wackfield(intentional misspelling) failed to get proper approval by an ethicscommittee for his studies, not to mention the fact he subjected autisticchildren to horribly invasive and unnecessarytests, he had his medical license revoked. 

 The vaccine in questionwas the MMR—which protects against measles, mumps, and rubella (“German measles��).This is a vaccine that children have been getting since the 70′s.

No one hasbeen able to replicate his findings, which is a big part of science. 

“Okay, maybethey don’t cause autism, but WHAT ABOUT THE MERCURY?”Okay, the “mercury” in some vaccines is Thimerosal, asubstance used as an antimicrobial in some vaccines. Now, there are two typesof mercury we should talk about, methylmercury and ethylmercury. Methylmercury is the “bad stuff.”This kind of mercury is not easily cleared from our bodies (and otherorganisms’ bodies), it’s the stuff that can accumulate in fish. It’s themercury people warn you about in fish. Ethylmercury ismore easily cleared from our bodies, and is therefore less harmful thanmethylmercury. Thimerosal contains ethylmercury. Making it, if you want to bevery general, safer than eating fish. Now, despite Thimerosal not being harmful, some federal agencies and vaccine manufacturersdecided to reduce or all-together stop using Thimerosal. This decision was in1999. Thimerosal was removed from ALL REQUIRED CHILDHOOD VACCINES in 2001.

Oh? And people who still,to this day, say they won’t give their kid the MMR because it has mercury…

The MMR vaccine NEVER CONTAINED THIMEROSAL TO BEGIN WITH.

If you’re that worriedabout mercury, just don’t feed your kid fish sticks???

 “Hm…still not aboutgiving my kids CHEMICALS. They are healthy, I’ll let them develop their ownimmunity.”

 So many things aboutthis statement are…misinformed. For your kid to get immunity in a natural way…theyfirst have to get sick. Now, if your kid is healthy, chances are they willsurvive the measles, or chickenpox. Buuut if your kid gets sick, chances arethey will spread it to other kids, possibly immunosuppressed kids who areusually fine because the population of immunized individuals in their area ishigh enough to “shield” them from certain illnesses. Your kid rolls up intoschool before they even feel sick, before you even take them out of school, butthey still get kids sick. And that…is pretty shitty. (I’ll talk more aboutthis in a second.)

 Basically, what vaccinesdo is expose you to small parts of the virus or bacteria that make you sick…withoutyou actually having to get sick. Usually, vaccines contain a protein that yourimmune system can look at and go “This is not right! I’m gonna make someantibodies against this so next time we see it, we can swiftly kill this thing”That’s how acquired immunity essentially works. (Some common vaccines are aweakened (so that they no longer make you sick) form of virus, they work thesame way.) So, I dunno, I think having a controlled way to have my kids developimmunity to something is better than running the risk of letting them getreally sick and spreading the illness to others.

Now, if you only careabout your kid and feel the health/safety of others is not your problem, let metell you how measles can kill your kid and babies!! 

First, if a pregnant person contracts measles, they may give birth prematurely,miscarry, or the baby can be born with systemic measles (meaning that the virusmay infect tissues it typically doesn’t, which can lead to a whole host ofhealth issues).

Now, this really bugsme about anti-vaxxers. A lot of anti-vaxxers I know also claim to be pro-life. Theysay all life is precious; they have no problem telling others what they shoulddo with their bodies, etc…but when it comes to them vaccinating their kids toprotect the lives of others…they say no one has the right to tell them what todo….They’ll yell about how you can’t kill unborn babies, but at the same time, they areputting other adults, children, and babies at risk when they refuse tovaccinate their kids!!

Many think measles is no big deal and no one is gonna die from it…but measles has complications that may affect your child! (I’m focusing on measles, because of the recent outbreaks because of people NOT VACCINATING THEIR KIDS). I’m mostlygonna focus on the scariest one: Subacutesclerosing panencephalitis. I’m too lazy to type my own words so here are theCDC’s: “(SSPE) is a very rare, but fatal disease of the central nervous systemthat results from a measles virus infection acquired earlier in life. SSPEgenerally develops 7 to 10 years after a person has measles, even though theperson seems to have fully recovered from the illness.” Now this condition isRARE, but it does happen, and it’s devastating. And there are true stories of kids getting this terrible condition and dying…. 

Anyway, I’mma stop here, because I could go on….

TL;DR:Anti-vaxxers frustrate me because they often spread misinformed or wildly inaccurateinformation about vaccination. And, sadly, even when you share objectivescience, they don’t believe you. Like, tbh if you really just don’t want tovaccinate your kid, that’s still up to you, BUT please stop spreading LIES toscare people and to justify yourself. 

[ebenpink]

Bad viruses travel fast: Measles vaccine important for travelers https://ift.tt/2zX7uw0

The United States was declared free from ongoing measles transmission in 2000. But we may be at risk for joining the U.K, Greece, Albania, and the Czech Republic, four countries recently stripped of measles elimination status by the World Health Organization. Since the beginning of 2019, more than 1,234 measles cases have been reported in 31 states, with active outbreaks in upstate New York and El Paso, Texas. New York has just declared the end of its yearlong outbreak, which required a massive public health response to control. Minnesota had a major measles outbreak in 2017. In 2015, 125 cases of measles occurred in California, and in 2014, 383 people were infected with measles in an Amish community in Ohio. Beyond our borders, measles outbreaks have also been a big problem in Europe and elsewhere – a point to be aware of if you’re traveling.

How measles outbreaks happen

There are several reasons why we are still at risk for measles outbreaks. Travelers may get infected overseas, and bring the measles virus back into the country with them unawares. The 2015 measles outbreak in Ohio began when two infected members of the Amish community returned home from typhoon relief work on the Philippines. The California measles outbreak in 2014 started at two Disney theme parks, perhaps after the virus was brought there by a foreign tourist.

In measles, there is an unusually long delay between infection and the development of the rash and other symptoms, typically about two weeks. Measles virus is also highly contagious. Patients start to spread the virus to other people about four days beforethe rash develops. These features make it possible for measles to spread quickly through an unsuspecting population.

The final component to measles outbreaks is inadequate immunity. Many American adults have only received a single dose of the measles, mumps, and rubella (MMR) vaccine, which is only 93% effective at preventing measles. Since 1989, the recommendation has been to give two doses of MMR, which is 97% protective against measles. Vaccination rates among patients in recent US outbreaks have been low, probably due to the success of anti-vaccine activists in pushing a debunked connection between autism and the MMR vaccine.

Measles infection can still be lethal

So, what’s the big deal about measles? For most people, measles makes for a miserable week of high fever, cough, runny nose, watery eyes, and an impressive total body rash. But for others, it can be a life-threatening, even fatal, condition. One out of every 20 measles patients develops pneumonia, which may be severe. Infection of the brain, or encephalitis, occurs in one out of 1,000 cases. Brain damage, deafness, intellectual disability, or death may result. Before the measles vaccine was available, measles killed 500 people in the US every year, most of them children, and led to 1,000 cases of brain damage per year.

Measles has an especially horrifying late complication known as subacute sclerosing panencephalitis (SSPE). In SSPE, children recover from their initial measles infection, only to develop progressive brain infection with a mutated form of measles virus in their teenage years, leading to a persistent vegetative state.

Many outbreaks of measles could probably be prevented if more travelers received MMR prior to foreign travel. According to a study done in US travel clinics, 16% of pre-travel patients were eligible for measles vaccine, but only a minority of patients received it. The authors of the study cited many reasons that patients didn’t receive the vaccine, with patient refusal being the most common. Next time you plan to travel overseas, think about protecting your community by asking your doctor if you are a candidate for the MMR vaccine before you leave.

Follow me at @JohnRossMD

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