#study at yale

[lionofchaeronea]

An Irish Wolfhound, Edwin Landseer (1802-1873)

[heleniad]

studying at yale young global scholars, 2024 july.

[inky-sun]

[pandemic-info]

What Is Long COVID? Understanding the Pandemic’s Mysterious Fallout > News > Yale Medicine

Originally published: April 15, 2024. Updated: June 4, 2024

Just weeks after the first cases of COVID-19 hit U.S. shores, an op-ed appeared in The New York Times titled “We Need to Talk About What Coronavirus Recoveries Look Like: They're a lot more complicated than most people realize.”

...

Unlike most diseases, Long COVID was first described not by doctors, but by the patients themselves. Even the term “Long COVID” was coined by a patient. Dr. Elisa Perego, an honorary research fellow at University College in London, came up with the hashtag #LongCOVID when tweeting about her own experience with the post-COVID syndrome. The term went viral and suddenly social media, and then the media itself, was full of these stories.

Complaints like "I can't seem to concentrate anymore" or "I'm constantly fatigued throughout the day" became increasingly common, seemingly appearing out of nowhere. With nothing abnormal turning up from their many thorough lab tests, patients and their physicians were left feeling helpless and frustrated.

The World Health Organization (WHO) has defined Long COVID as the "continuation or development of new symptoms three months after the initial SARS-CoV-2 infection, with these symptoms lasting for at least two months with no other explanation." This deliberately broad definition reflects the complex nature of this syndrome. We now understand that these symptoms are wide-ranging, including heart palpitations, cough, nausea, fatigue, cognitive impairment (commonly referred to as "brain fog"), and more. Also, many who experience Long COVID following an acute infection face an elevated risk of such medical complications as blood clots and (type 2) diabetes.

In April 2024, an estimated 5.3% of all adults in the United States reported having Long COVID, according to the Centers for Disease Control and Prevention (CDC). Data from the CDC suggest that Long COVID disproportionately affects women, and individuals between the ages of 40 and 59 have the highest reported rates of developing this post-acute infection syndrome.

...

Inderjit Singh, MBChB, a YSM assistant professor specializing in pulmonary, critical care, and sleep medicine, and director of the Pulmonary Vascular Program, is actively engaged in clinical trials aimed at uncovering the fundamental underpinnings of Long COVID.

...

Through this work, a significant revelation emerged. They observed that patients grappling with Long COVID and facing exercise difficulties were unable to efficiently extract oxygen from their bloodstream during physical exertion. This discovery identifies a specific cause underlying the biological underpinnings of Long COVID.

... Dr. Singh, along with other researchers, is focused on the identification of blood-based markers to assess the severity of Long COVID. For example, a research group, led by Akiko Iwasaki, PhD, Sterling Professor of Immunobiology and Molecular, Cellular, and Developmental Biology, and director of the Center for Infection & Immunity at YSM, most recently created a new method to classify Long COVID severity with circulating immune markers.

Further investigations conducted by Dr. Singh's team identified distinctive protein signatures in the blood of Long COVID patients, which correlated with the degree of Long COVID severity. Researchers identified two major and distinct blood profiles among the patients. Some of them exhibited blood profiles indicating that excessive inflammation played a prominent role in their condition, while others displayed profiles indicative of impaired metabolism.

...

Researchers currently believe that the impairment of a spectrum of key bodily functions may contribute to these diverse symptoms. These potential mechanisms include compromised immune system function, damage to blood vessels, and direct harm to the brain and nervous system. Importantly, it's likely that most patients experience symptoms arising from multiple underlying causes, which complicates both the diagnosis and treatment of Long COVID.

...

The last word from Lisa Sanders, MD:

I’m the internist who sees patients at Yale New Haven Health’s Multidisciplinary Long COVID Care Center. In our clinic, patients are examined by a variety of specialists to determine the best next steps for these complex patients. Sometimes that entails more testing. Often patients have had extensive testing even before they arrive, and far too often—when all the tests are normal—both doctors and patients worry that their symptoms are “all in their head.”

One of our first tasks is to reassure patients that many parts of Long COVID don’t show up on tests. We don’t know enough about the cause of many of these symptoms to create a test for them. The problem is not with the patient with the symptoms, but of the science surrounding them. If any good can be said to come out of this pandemic, it will be a better understanding of Long COVID and many of the other post-acute infection syndromes that have existed as long as the infections themselves.

[gostudyorillcomeforyou]

Scrolling through Tumblr huh? Go on, waste your time while your competition works. What do you want? Harvard, Yale, Princeton, NYU, Stanford? Someone who wants the same place as you probably works harder than you right. Maybe you want to get that job? I guess you’re not the only one applying, are you? I’m just saying… Anyway I don’t really mind if you procrastinate, you’re just eliminating yourself, so I don’t have competition, thanks

[starcademia]

I'm going to YALE!!!

[adastrapoetsclub]

She craves academic validation🏛️🖋️🎧☕️

[keirametzbrassknuckles]

Like wait okay let's unpick this:

Eskel wants to be good, wants to be the best, and actively works for it because his skill at his job and other's opinions of him are the only things that matter to him. Without witchering he's nothing. His self loathing is only barely held back by his need to be needed, his need to people please. Without the structure, without killing monsters he's nothing. He is, however, innately magically gifted though that's nearly useless. Maybe in another life he could have been someone but not this one. Not now.

Geralt is, I would argue, middle of the pack at best in terms of true Witchering talent and yet he's got the machinations of destiny on his side and his own intellect. Like Eskel he has talents that aren't necessarily valued by his profession but he was actually able to skate by during training with little practice. His job is a job he does to pay the bills when he's not undergoing The Horrors. It's secondary to both his life and his identity after a certain point.

Lambert, on the other hand, is pure talent. He's innately gifted with swords, has a scientific mind that lends itself to potion brewing and bomb building to the point that he actively reformulates decoctions that have been standard for centuries making them better and more effective - not because he cares but because it's a fun challenge to pit himself against. But he, unlike his brothers, hates who and what he is. Hates what's been made of him and what he has to do. He's railed against it since day one and would give it up in a heartbeat if the opportunity presented itself. And yet, and yet, he's the most naturally talented, the most optimally suited for the job, that anyone has ever seen. A prodigy.

[garadinervi]

Margaret Konkol, Prototyping Mina Loy’s alphabet, «Feminist Modernist Studies», Volume 1, 2018, pp. 294-317 – Issue 3: Special Cluster: Feminist Modernist Digital Humanities (pdf here)

(image: Mina Loy, The Alphabet That Builds Itself, Alphabet, No II, n.d. [1941]. Mina Loy papers, Box 7, Folder 184, YCAL MSS 6. Yale University Library, Beinecke Rare Book and Manuscript Library, New Haven, CT)

[fwteinhs-diary]

Today’s study motivation📚

[backstabbingfarter]

the pure rush of excitement that you can hear in the Johns’ voices when they’re about to speak a french lyric can only be described as borderline orgasmic.

they won’t tell you this but Here Comes Science was actually inspired by their brief observation by the world’s top scientist to find out how such pure joy and pleasure can be incited by such an annoying language

[blairwinterss]

rory gilmore 🧸🧸

[chiropteracupola]

be near to me...

[flintlock fortress is, as always, a collaboration with @dxppercxdxver]

[heleniad]

Yale Young Global Scholars pt 2

[inthedarktrees]

Yale Joel, “Public High School, U.S.A.,” Life, Dec 15, 1953

[gostudyorillcomeforyou]

DO IT!

JUST DO IT!

DON’T LET YOUR DREAMS BE DREAMS

YESTERDAY YOU SAID TOMMOROW

SO JUST DO IT

MAKE YOUR DREAMS COME TRUE

JUST DO IT

SOME PEOPLE DREAM SUCCESS WHILE YOU GONNA WAKE UP AND WORK HARD AT IT

NOTHING IS IMPOSSIBLE

YOU SHOULD GET TO THE POINT WHERE ANYONE ELSE WOULD QUIT AND YOU’RE NOT GONNA STOP THERE

NO, WHAT ARE YOU WAITING FOR

DO IT

(it’s from an audio that I found, but I can’t copy it here) (it was probably said by some alpha male, gym rat, but we’re doing it in a hot girl, Blair Waldorf way)