#sound effects*****

[rayhantochtli]

They're all grown men

[weevmo]

Tsk - Should have read the manual.

[siyelius]

he’s like that weird uncle that won’t stop randomly showing up for family events despite cutting him off 23 years ago for felony fraud charges

[reasonsforhope]

A new treatment combining ReCET and semaglutide could eliminate the need for insulin in type 2 diabetes, with 86% of participants in a study no longer requiring insulin therapy. The treatment was safe and well-tolerated, and further trials are planned to confirm these results.

Groundbreaking research presented at UEG Week 2024 introduces a promising new treatment approach for type 2 diabetes (T2D) that has the potential to greatly reduce or even eliminate the need for insulin therapy.

This innovative approach, which combines a novel procedure known as ReCET (Re-Cellularization via Electroporation Therapy) with semaglutide, resulted in the elimination of insulin therapy for 86% of patients.

Globally, T2D affects 422 million people... While insulin therapy is commonly used to manage blood sugar levels in T2D patients, it can result in side effects... and further complicate diabetes management. [Note: Also very importantly it's fucking bankrupting people who need it!!] A need therefore exists for alternative treatment strategies.

Study Design and Outcomes

The first-in-human study included 14 participants aged 28 to 75 years, with body mass indices ranging from 24 to 40 kg/m². Each participant underwent the ReCET procedure under deep sedation, a treatment intended to improve the body’s sensitivity to its own insulin. Following the procedure, participants adhered to a two-week isocaloric liquid diet, after which semaglutide was gradually titrated up to 1mg/week.

Remarkably, at the 6- and 12-month follow-up, 86% of participants (12 out of 14) no longer required insulin therapy, and this success continued through the 24-month follow-up. In these cases, all patients maintained glycaemic control, with HbA1c levels remaining below 7.5%.

Tolerability and Safety

The maximum dose of semaglutide was well-tolerated by 93% of participants, one individual could not increase to the maximum dose due to nausea. All patients successfully completed the ReCET procedure, and no serious adverse effects were reported.

Dr Celine Busch, lead author of the study, commented, “These findings are very encouraging, suggesting that ReCET is a safe and feasible procedure that, when combined with semaglutide, can effectively eliminate the need for insulin therapy.”

“Unlike drug therapy, which requires daily medication adherence, ReCET is compliance-free [meaning: you don't have to take it every day], addressing the critical issue of ongoing patient adherence in the management of T2D. In addition, the treatment is disease-modifying: it improves the patient’s sensitivity to their own (endogenous) insulin, tackling the root cause of the disease, as opposed to currently available drug therapies, that are at best disease-controlling.”

Looking ahead, the researchers plan to conduct larger randomized controlled trials to further validate these findings. Dr. Busch added, “We are currently conducting the EMINENT-2 trial with the same inclusion and exclusion criteria and administration of semaglutide, but with either a sham procedure or ReCET. This study will also include mechanistic assessments to evaluate the underlying mechanism of ReCET.”

-via SciTechDaily, October 17, 2024

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Note: If it works even half as well as suggested, this could free so many people from the burden of the ongoing ridiculous cost of insulin. Pharma companies that make insulin can go choke (hopefully).

[blackkatdraws2]

[Toon x Mobster] A tender moment.

[Animation timelapse here!]

[AUDIO USED:] Chet Baker - Almost Blue Sound Effects edited by me!

[ruushes]

> pull her into a hug

[bluepandadraws-log]

The Amazing Digital COMIC #44-Ass Ahoy

☕Ko-Fi || [❤PREV] || [🧡START🧡] || [NEXT💙] || Full Comic🎪

[cyberpchela]

Fun! Fun! Fun!

Update; also uploaded on YT shorts, you can check it out!

[tchaikovskaya]

[official-penis-posts]

what's your favorite dick sound effect?

Umm…what’s yours?

[corseque]

I realized that I could easily do the same to DAI's script, and I did that, but then I immediately created my magnum opus:

A Text File of Everything Solas Says In Inquisition and Veilguard, The Ultimate Fanfic Resource For Writing Solas' Voice*

and I fell on the floor because it made me happy.

*edited to correct a minor mishap

[egophiliac]

tsum events continue to be just the best

[catmask]

sometimes while i think about that while a lot of adults did not treat me very well as a kid i also get a lot of 'in hindsight this person was so good to me and i didnt even realize it until now' as an adult. today i was thinking about how the first anime convention i ever went to was when i was 10 and i asked the man working the manga cafe what manga was/what a good place to start was (because the con was very overstimulating for me and i had gotten lost) and he asked how old i was before recommending yotsuba and asking if i wanted any water or something to eat. its really simple but theres a lot of bad things that couldve happened or he could've been careless in his recommendation, but instead yotsuba has remained one of my favorite manga for years, and probably a large portion of why i continue to read manga as an adult... i think adults who try to involve kids in the world safely/kindly even in little ways make so much more of a difference than they ever really know.

[sprinklesharkie]

get bonked

[loveexpelrevolt]

How about the winner get a kiss from the loser? Do you wanna end up in a coma? You can drain my energy any time, chère. Gambit has plenty.

GAMBIT & ROGUE | X-Men '97 1.03 "Fire Made Flesh"

[xxacidnekoxx]

They go downstream!