#schneider marker

[covid-safer-hotties]

Also preserved on our archive

Another perfect example of how masking to help prevent covid keeps us *all* safer from *all* airborne illness.

by Tamara Schneider

Lingering respiratory viruses set the stage for chronic lung disease, mouse study shows

Doctors have long known that children who become seriously ill with certain respiratory viruses such as respiratory syncytial virus (RSV) are at elevated risk of developing asthma later in life. What they haven’t known is why.

A new study by researchers at Washington University School of Medicine in St. Louis may have solved the mystery. The study, in mice, shows that respiratory viruses can hide out in immune cells in the lungs long after the initial symptoms of an infection have resolved, creating a persistently inflammatory environment that promotes the development of lung disease. Further, they showed that eliminating the infected cells reduces signs of chronic lung damage before they progress to a full-blown chronic respiratory illness.

The findings, published Oct. 2 in Nature Microbiology, point to a potential new approach to preventing asthma, chronic obstructive pulmonary disease (COPD) and other chronic lung diseases by eradicating the persistent respiratory viruses that fuel these conditions.

“Right now, children who have been hospitalized for a respiratory infection such as RSV are sent home once their symptoms resolve,” said senior author Carolina B. López, PhD, a professor of molecular microbiology and a BJC Investigator at WashU Medicine. “To reduce the risk that these children will go on to develop asthma, maybe in the future we will be able to check if all of the virus is truly gone from the lung, and eliminate all lingering virus, before we send them home.”

About 27 million people in the U.S. are living with asthma. Many factors influence a person’s likelihood of developing the chronic breathing illness, including living in a neighborhood with poor air quality, having exposure to cigarette smoke and being hospitalized for viral pneumonia or bronchitis while young. Some researchers — López included — suspected that the link between serious lung infection and subsequent asthma diagnosis was due to lingering virus in the lungs that causes ongoing damage, but a direct link between the ongoing presence of virus and chronic lung disease has not been previously shown.

López and first author Ítalo Araújo Castro, PhD, a postdoctoral researcher in her lab, developed a unique system involving a natural mouse virus known as Sendai virus, and fluorescent markers of infection. Sendai is related to human parainfluenza virus, a common respiratory virus that, like RSV, has been linked to asthma in children. Sendai behaves in mice in very much the same way that human parainfluenza virus behaves in people, making it an excellent model of the kinds of infections that could lead to chronic lung disease.

Using the fluorescent trackers, the researchers could observe signs of the virus throughout infection. After about two weeks, the mice recovered, but viral RNA and protein were still detectable several weeks later in their lungs, hidden away in immune cells.

“Finding persistent virus in immune cells was unexpected,” López said. “I think that’s why it had been missed before. Everyone had been looking for viral products in the epithelial cells that line the surface of the respiratory system, because that’s where these viruses primarily replicate. But they were in the immune cells.”

Moreover, the presence of the virus changed the behavior of the infected immune cells, causing them to become more inflammatory than the uninfected immune cells. Persistent inflammation sets the stage for chronic lung disease to arise, the researchers said. Indeed, seven weeks after infection, the mice’s lungs exhibited inflammation of air sacs and blood vessels, abnormal development of lung cells and excess immune tissue — all signs of chronic inflammatory lung damage, even though the mice appeared outwardly to have recovered. Once the infected immune cells were eliminated, the signs of damage diminished.

“We use a perfectly matched virus-host pairing to prove that a common respiratory virus can be maintained in immunocompetent hosts for way longer than the acute phase of the infection, and that this viral persistence can result in chronic lung conditions,” Castro said. “Probably the long-term health effects we see in people who are supposed to be recovered from an acute infection are actually due to persistence of virus in their lungs.”

The findings point to new ways to think about preventing chronic lung diseases, the researchers said.

“Pretty much every single child gets infected with these viruses before the age of 3, and maybe 5% get serious enough disease that they could potentially develop persistent infection,” López said. “We’re not going to be able to prevent children from getting infected in the first place. But if we understand how these viruses persist and the effects that persistence has on the lungs, we may be able to reduce the risk of serious long-term problems.”

Study: Castro IA, Yang Y, Gnazzo V, Kim DH, Van Dyken SJ, López CB. Murine parainfluenza virus persists in lung innate immune cells sustaining chronic lung pathology. Nature Microbiology. Oct. 2, 2024. DOI: 10.1038/s41564-024-01805-8

www.nature.com/articles/s41564-024-01805-8 (PAYWALLED)

[ama-jewel]

@libras-interactives So here are their names and some info about them

This is Alice Shire, she's the musician.

She's from England(she's Irish in the fic cause that's whats closest to the UK). She's definitely the smartest among my OC's second to Aminul.Also she's partially deaf

This is Ava Simons, She's the gunman. Her son's name is Carl

She's French (Italian in the fic cause thats the closest to France) I just imagine Marius, Evelyn and Ava talking in French and Jack: "...." I imagine them (or atleast her)trying to teach him if he wanted to learn.

She adopted her son cause yk the eyes, she was ill-treated as a kid for her eyes and dosen't want him to go through the same.

RIP my black marker

This is Αμάρα κόσμημα (pronounced Amara Kosmima, kosmima means jewel in greek) She's the callgirl

She's from Greece. She's the youngest out of all of them. She makes it a point to befriend all members of the Duchess (or atleast be on friendly terms with them) She's friends with my other OCs and gets along with everyone else just fine. She sees Aminul as an older brother,she tries to stay around him whenever she's not working and hes not at Mr.Flynn's law firm.she's wearing his jacket.

If you had all 4 of them compete in a driving race she would win

also her outfit is inspired by(itslitrallythesamejustadifferentcolour) Schneider from Reverse 1999

This is Aminul Shilva, he eats books...get it...cause he cooks books....it was funny in my head.

He's Filipino. There's no relation between him and Ava's son(they look alike)His and Amara's dynamic is literally Sunshine and Sunshine protector, no small crushes or anything just sibling energy to the max. He doesn't come to the duchess often so he only knows Marius, Jack, Alice and Amara.I actually think him and Mordecai would get along pretty well, same personality just less...intense yk,isnt asss serious as Mordecai.

i realised after all of this that i didnt outline some parts of him

[linguistlist-blog]

Confs: Discourse Markers: Markers in Discourse and Markers on Discourse

Friday 21-06-24 8h45 : Arrivals 9h15 : Opening speech 9h30-10h30 : Guest speaker, Maj-Britt Mosegaard Hansen Grammaticalization vs pragmaticalization: a multidimensional model of the evolution of pragmatic markers and discourse markers 10h30 : Coffee break General Perspectives on Discourse Markers 11h00 : Stefan Schneider Dans la phrase et sur le discours. Genèse et évolution des marqueurs déverbaux 11h00 : Carlos Meléndez Quero Perspectives de recherche pour les marqueurs dans et sur l http://dlvr.it/T7nHyn

[dipikazz]

Asset Performance Management Market: Examined in New Market Research

The Insight Partners declares the examination on Worldwide Resource Execution Asset Performance Management Market. This Worldwide Resource Execution Asset Performance Management Market Report covers around the world, nearby, and country level market size, bits of the general business, progressing design, the impact of covid19 on around the world

Statistical surveying Report Examinations Exploration Approach audit involves Optional Exploration, Essential Exploration, Organization Offer Investigation, Model (counting Segment data, Macroeconomic pointers, and Industry markers for instance Use, structure, region improvement, and workplaces, etc), Exploration Impediments and Income Based Displaying. Complete assessment of Worldwide Resource Execution The executives Market In view of current examination and future assessment, which relies upon prominent data moreover remembered for this Reports. Presenting the Worldwide Resource Execution, The executives Market Component Investigation Doormen Five Powers, Supply/Worth Chain, PESTEL assessment, CAGR regard, Market Entropy, Patent/Brand name Examination, and Post Coronavirus Effect Investigation.

(**Note: The example of this report is refreshed with Coronavirus influence analysis**)

To Know What Coronavirus Pandemic Will Mean for Worldwide Resource Execution The executives Market |

Get an Example Duplicate of Report, Snap Here:

Report Presentation, Outline, and top to bottom industry investigation

•              150+ Pages Exploration Report

•              Incorporates Rundown of table and figures

•              Local Investigation with Graphical Portrayal of Size, Offer and Patterns

•              Give Part wise direction on Solicitation

•              Realities and Elements research system

•              Report Incorporates Top Market Players with their Business Procedure, Deals Volume, and Income Examination

NOTE: Our examiners checking what is going on across the globe makes sense of that the market will create gainful possibilities for makers post the Coronavirus emergency. The report intends to give an extra outline of the most recent situation, monetary log jam, and Coronavirus influence on the general business.

The report is a mix of subjective and quantitative investigation of the computer-generated experience industry. The worldwide market significantly thinks about five significant districts, to be specific, North America, Europe, Asia-Pacific (APAC), Center East and Africa (MEA) and South and Focal America (SACM). The report additionally centers around the comprehensive Bug examination and broad market elements during the estimate time frame.

Organizations Referenced:

1. ABB Ltd.

2. Aspen Innovation Inc.

3. AVEVA Gathering plc

4. Bentley Frameworks Consolidated

5. General Electric Organization

6. Intel Enterprise

7. Worldwide Business Machines Partnership

8. OSIsoft LLC

9. Schneider

10. Siemens AG

Motivation to Purchase

•              Save and decrease time completing passage level examination by recognizing the development, size, driving players and portions in the worldwide Resource Execution Asset Performance Management market.

•              Features key business needs to direct the organizations to change their business techniques and secure themselves in the wide geology.

•              The critical discoveries and proposals feature significant moderate industry patterns in the Resource Execution Asset Performance Management market, consequently permitting players to foster powerful long haul methodologies to earn their market income.

•              Create/alter business extension plans by utilizing significant development offering created and developing business sectors.

•              Examine top to bottom worldwide market patterns and viewpoint combined with the elements driving the market, as well as those limiting the development at a specific degree.

•              Upgrade the dynamic interaction by understanding the techniques that support business interest regarding items, division and industry verticals.

Gratitude for perusing this article; you can likewise modify this report to get select sections or district wise inclusion with locales like Asia, North America, and Europe.

[stari-hun]

I think the 15 is def for if Vertin encounters more humans she needs to save, and she's using Schneider as a marker for how many umbrellas she needs to save an entire family. Kakania doesn't show up in Arcanist in a Nutshell with an umbrella despite likely going to Vertin's team after she was retrieved (idk about her character story yet).

So

Have y'all thought about how Vertin asked for 15 equlibrium umbrellas?

Well, Schneider had 12 sisters and 2 parents.

1+12+2=15

She wants to make sure she can save them all if she ever sees them again. Your welcome.

*posts this and runs*

[gabi-toma]

I wanted to see how the Schneider acrylic markers perform on fabric so I decided to use them on a tote bag. Here is a short process video of me drawing what else but a cat 😂

I wanted to do a super simple design because a more complex one would have had a longer drying time. After finishing it I ironed the bag (on both sides) and I also washed it at 40 degrees Celsius. The colors faded a bit but still look nice (I think 30 degrees Celsius would have been a better choice), but the tote shrunk by 15% 😂😂😂 (wasn't expecting that).

All in all it was a fun process.

[adellaashawk]

🇮🇹 Dovrei vergognarmi dalla frequenza dei miei post? Sì. Ma dopo il Lucca Comics, che per me è super stressante, in cui ho ottenuto un pennarellino Schneider aggratis, disegnare viene molto più naturale.

Feat: 1. Michi che se la prende col papa, 2. Raff, che nella mia testa è stato e sempre sarà un fashionista, si becca gli insulti (con amore), 3. Raff a cavallo (è la prima volta che disegno un cavallo da SECOLI, grazie Pinterest).

🇬🇧 Should I be ashamed by the frequency of my posting? Yes. But, after Lucca Comics (the biggest comicon in Italy, the most stressful event of my year) in which I got a Schneider marker for free, drawing seems so much fun.

Feat: 1. Michelangelo getting angry at the pope ("The pope?! I'll show it to the pope!"), 2. Raffaello/Raphael, who has always been a fashionista in my head, that gets insults in a lovely way ("People keep calling you 'fashionista', I don't know what that means, but I'll use it as an insult, sounds good?), 3. Raffaello on a horse (I haven't drawn a horse in CENTURIES).

[johnschneiderblog]

Yard ornament

Long before we set up camp on this shoreline, somebody - either a person who lived here, or next-door - decided to create a permanent property marker.

Buried beneath this metal pole is what I estimate to be 2.5 cubic buttloads of concrete. I base this on our exertions trying to remove it, and upon the fact that it has stood through all the low-water/high-water cycles nature could dish out over 30 years.

Even though it’s been in the periphery of our vision for all that time we decided only this spring that it had to go. “Have at it,” said the man who lives on the other side of the property line. 

So, over the weekend, Sharon and I dug and dug and dug. We pushed, pulled, kicked, cussed and cursed .... It barely budged.

Then we started thinking ... Maybe the person who worked so hard to make the marker permanent had a point; maybe it will prove to be an invaluable reference to a future property survey.

So, Sharon strapped a sunflower to it. We’ll call it a yard ornament.

[samyrandomness-blog]

A girl and her first pokemon! Sooo cuttteee!! Love love love ittt! Holy crap!!!

[interorbitalteeth]

Marker portrait of Luther Hargreeves kissing his boyfriend, @startrekfemme‘s Zed Schneider. Yes, Luther is gay, no, I won’t elaborate.

[notafraidofredyellowandblue]

Montreal 2022-08-21 Crowdboating

from yt channel Alejandro Rozo

First and foremost: no mic-stands were harmed in the making of this post 😊 Till thanked the crowd very lovingly and stayed away from the mics 😊

Paul decided to sneak up on Schneider

"Hey! No tickling!"

Schneider gives the "Let's go" (any excuse to post that top 😊)

Flake is determined to remain standing

Paul is in his element today, greeting the crowd

Dramatic depiction of guitarist sailing away

...and playing air-guitar.. (and Olli is...Olli 🍀)

Richard...well, he had trouble with his marker (wonder if Joe Letz is still there to hand him his stuff)

...and Richard's boat sways a long way away, so the others have to wait again, Paul taps his sign to make sure Richard knows he's 'Wilkommen' on stage 😊

[jordi-gali]

View this post on Instagram

A post shared by Stephan Paul Schneider (@stephanpaulschneider)

Stephan Paul Schneider, von links nach rechts:

„Untitled”, 2022, acrylic lacquer, pigments, marker, tape between layers of plastic foil on stretcher frame), 50 x 35 cm.

“Untitled (Tribute to Volodymyr Zelenskyy)”, 2022, mixed media (plastic foil, stretcher frame, different tapes, paper foam, paper, acrylics), 35 x 30 +3 + 23,7 x 9 cm

„Untitled“, 2002, diptych, 18 x 13 + 13 cm, acrylics, pigments on cotton duck.

„Untitled”, 2022, mixed media (matte acrylic lacquer, pigments, marker on cover fleece on stretcher frame), 35 x 20 cm

„Untitled”, 2022, acrylic, pigments, on cover fleece on stretcher frame, 35 x 20 cm

[gotankgo]

«The Smart Studios Story is a 2016 documentary film written, directed and co-produced by Wendy Schneider. The film chronicles the history and impact of Madison, Wisconsin-based recording studio Smart Studios, founded by Butch Vig and Steve Marker in 1983.»

streaming for free today

[namii-pisces]

I recently started drawing again and this is my most recent work ☺ I know there are a few details that aren't completely the same as the original, but I'm still practising! 😊 please tell me what you think, so I know what details I should work on more :3

[airmanisr]

Supermarine S.6A ‘N248’ by Alan Wilson Via Flickr: c/n unknown. Built in 1929 as a Supermarine S.6 and entered in the 1929 Schneider Trophy race. She was disqualified for turning inside a marker, but still set world records for closed circuits of 50 and 100km. For the 1931 race she was rebuilt with new floats and a bigger engine and was redesignated as an S.6A. She did not take part in the event, being kept in reserve, although the S.6Bs ‘N1595’ and ‘N1596’ were successful in winning and retaining the title as well as setting a world airspeed record. N248 was falsely marked as N1596 for many years, but returned to her correct markings for the opening of the Southampton Hall of Aviation in 1983. Solent Sky, Southampton, Hampshire, UK 21st August 2020

[johnschneiderblog]

Preparing for battle

Thursday morning’s heavy frost reminded me of a perennial task that I’m never eager to do because of its implications: planting markers so I can find and clear our quarter-mile-long driveway when snow turns the landscape into one giant blanket.

Meanwhile, the boiler has been tuned up, the firewood cut and split, the humidifier exhumed from the dark recesses of the basement ...

Next on my list: installing the snow blower on my tractor, along with the tire chains and weights

There’s no getting around it: Mid-November is upon us.