#schneider marker

[covid-safer-hotties]

Also preserved on our archive

Another perfect example of how masking to help prevent covid keeps us *all* safer from *all* airborne illness.

by Tamara Schneider

Lingering respiratory viruses set the stage for chronic lung disease, mouse study shows

Doctors have long known that children who become seriously ill with certain respiratory viruses such as respiratory syncytial virus (RSV) are at elevated risk of developing asthma later in life. What they haven’t known is why.

A new study by researchers at Washington University School of Medicine in St. Louis may have solved the mystery. The study, in mice, shows that respiratory viruses can hide out in immune cells in the lungs long after the initial symptoms of an infection have resolved, creating a persistently inflammatory environment that promotes the development of lung disease. Further, they showed that eliminating the infected cells reduces signs of chronic lung damage before they progress to a full-blown chronic respiratory illness.

The findings, published Oct. 2 in Nature Microbiology, point to a potential new approach to preventing asthma, chronic obstructive pulmonary disease (COPD) and other chronic lung diseases by eradicating the persistent respiratory viruses that fuel these conditions.

“Right now, children who have been hospitalized for a respiratory infection such as RSV are sent home once their symptoms resolve,” said senior author Carolina B. López, PhD, a professor of molecular microbiology and a BJC Investigator at WashU Medicine. “To reduce the risk that these children will go on to develop asthma, maybe in the future we will be able to check if all of the virus is truly gone from the lung, and eliminate all lingering virus, before we send them home.”

About 27 million people in the U.S. are living with asthma. Many factors influence a person’s likelihood of developing the chronic breathing illness, including living in a neighborhood with poor air quality, having exposure to cigarette smoke and being hospitalized for viral pneumonia or bronchitis while young. Some researchers — López included — suspected that the link between serious lung infection and subsequent asthma diagnosis was due to lingering virus in the lungs that causes ongoing damage, but a direct link between the ongoing presence of virus and chronic lung disease has not been previously shown.

López and first author Ítalo Araújo Castro, PhD, a postdoctoral researcher in her lab, developed a unique system involving a natural mouse virus known as Sendai virus, and fluorescent markers of infection. Sendai is related to human parainfluenza virus, a common respiratory virus that, like RSV, has been linked to asthma in children. Sendai behaves in mice in very much the same way that human parainfluenza virus behaves in people, making it an excellent model of the kinds of infections that could lead to chronic lung disease.

Using the fluorescent trackers, the researchers could observe signs of the virus throughout infection. After about two weeks, the mice recovered, but viral RNA and protein were still detectable several weeks later in their lungs, hidden away in immune cells.

“Finding persistent virus in immune cells was unexpected,” López said. “I think that’s why it had been missed before. Everyone had been looking for viral products in the epithelial cells that line the surface of the respiratory system, because that’s where these viruses primarily replicate. But they were in the immune cells.”

Moreover, the presence of the virus changed the behavior of the infected immune cells, causing them to become more inflammatory than the uninfected immune cells. Persistent inflammation sets the stage for chronic lung disease to arise, the researchers said. Indeed, seven weeks after infection, the mice’s lungs exhibited inflammation of air sacs and blood vessels, abnormal development of lung cells and excess immune tissue — all signs of chronic inflammatory lung damage, even though the mice appeared outwardly to have recovered. Once the infected immune cells were eliminated, the signs of damage diminished.

“We use a perfectly matched virus-host pairing to prove that a common respiratory virus can be maintained in immunocompetent hosts for way longer than the acute phase of the infection, and that this viral persistence can result in chronic lung conditions,” Castro said. “Probably the long-term health effects we see in people who are supposed to be recovered from an acute infection are actually due to persistence of virus in their lungs.”

The findings point to new ways to think about preventing chronic lung diseases, the researchers said.

“Pretty much every single child gets infected with these viruses before the age of 3, and maybe 5% get serious enough disease that they could potentially develop persistent infection,” López said. “We’re not going to be able to prevent children from getting infected in the first place. But if we understand how these viruses persist and the effects that persistence has on the lungs, we may be able to reduce the risk of serious long-term problems.”

Study: Castro IA, Yang Y, Gnazzo V, Kim DH, Van Dyken SJ, López CB. Murine parainfluenza virus persists in lung innate immune cells sustaining chronic lung pathology. Nature Microbiology. Oct. 2, 2024. DOI: 10.1038/s41564-024-01805-8

www.nature.com/articles/s41564-024-01805-8 (PAYWALLED)

[ama-jewel]

@libras-interactives So here are their names and some info about them

This is Alice Shire, she's the musician.

She's from England(she's Irish in the fic cause that's whats closest to the UK). She's definitely the smartest among my OC's second to Aminul.Also she's partially deaf

This is Ava Simons, She's the gunman. Her son's name is Carl

She's French (Italian in the fic cause thats the closest to France) I just imagine Marius, Evelyn and Ava talking in French and Jack: "...." I imagine them (or atleast her)trying to teach him if he wanted to learn.

She adopted her son cause yk the eyes, she was ill-treated as a kid for her eyes and dosen't want him to go through the same.

RIP my black marker

This is Αμάρα κόσμημα (pronounced Amara Kosmima, kosmima means jewel in greek) She's the callgirl

She's from Greece. She's the youngest out of all of them. She makes it a point to befriend all members of the Duchess (or atleast be on friendly terms with them) She's friends with my other OCs and gets along with everyone else just fine. She sees Aminul as an older brother,she tries to stay around him whenever she's not working and hes not at Mr.Flynn's law firm.she's wearing his jacket.

If you had all 4 of them compete in a driving race she would win

also her outfit is inspired by(itslitrallythesamejustadifferentcolour) Schneider from Reverse 1999

This is Aminul Shilva, he eats books...get it...cause he cooks books....it was funny in my head.

He's Filipino. There's no relation between him and Ava's son(they look alike)His and Amara's dynamic is literally Sunshine and Sunshine protector, no small crushes or anything just sibling energy to the max. He doesn't come to the duchess often so he only knows Marius, Jack, Alice and Amara.I actually think him and Mordecai would get along pretty well, same personality just less...intense yk,isnt asss serious as Mordecai.

i realised after all of this that i didnt outline some parts of him

[jordi-gali]

View this post on Instagram

A post shared by Stephan Paul Schneider (@stephanpaulschneider)

Stephan Paul Schneider, von links nach rechts:

„Untitled”, 2022, acrylic lacquer, pigments, marker, tape between layers of plastic foil on stretcher frame), 50 x 35 cm.

“Untitled (Tribute to Volodymyr Zelenskyy)”, 2022, mixed media (plastic foil, stretcher frame, different tapes, paper foam, paper, acrylics), 35 x 30 +3 + 23,7 x 9 cm

„Untitled“, 2002, diptych, 18 x 13 + 13 cm, acrylics, pigments on cotton duck.

„Untitled”, 2022, mixed media (matte acrylic lacquer, pigments, marker on cover fleece on stretcher frame), 35 x 20 cm

„Untitled”, 2022, acrylic, pigments, on cover fleece on stretcher frame, 35 x 20 cm

[linguistlist-blog]

Confs: Discourse Markers: Markers in Discourse and Markers on Discourse

Friday 21-06-24 8h45 : Arrivals 9h15 : Opening speech 9h30-10h30 : Guest speaker, Maj-Britt Mosegaard Hansen Grammaticalization vs pragmaticalization: a multidimensional model of the evolution of pragmatic markers and discourse markers 10h30 : Coffee break General Perspectives on Discourse Markers 11h00 : Stefan Schneider Dans la phrase et sur le discours. Genèse et évolution des marqueurs déverbaux 11h00 : Carlos Meléndez Quero Perspectives de recherche pour les marqueurs dans et sur l http://dlvr.it/T7nHyn

[dankusner]

A Handy Guide to Faking Your Own Death

Photo by Jamie Lee Curtis Taete

Faking your own death is a timeworn tradition. Whether it's to collect on a life-insurance policy, escape a criminal conviction, or to simply disappear, people have been playing dead for centuries. It's hard to say exactly how many people have pulled it off successfully, because a successful pseudocide just looks like a real death.

There are, however, plenty of death fakers who don't pull it off. Their plots, the motivations behind them, and the ways they get caught are at the heart of the book Playing Dead: A Journey Through the World of Death Fraud, which was recently released. I spoke to the book's author, Elizabeth Greenwood, to find out how some people fake their own deaths and why it's never a good exit strategy.

VICE: How many people do you estimate fake their own deaths? Elizabeth Greenwood: It really is hard to say because if people fake their deaths successfully, then they're just considered dead. The real marker for it, and the people who tend to get caught, are people who try to commit life insurance fraud. There are several red flags that come up—like, if you've recently increased your coverage in the past year or two, or [if your coverage is] not commensurate with your net worth. Insurance adjusters just have a sixth sense about when something about a death is "off." If all these stars align, then they'll send out investigators to really suss out what happened.

The investigators I interviewed, they subcontract for a number of companies. They are personally investigating dozens of them a year. If I had to guess, I would put it at several hundred a year. But that is very anecdotal.

Is pseudocide illegal? To advance the idea that you are dead really doesn't violate any sort of legal code, but all the ancillary steps involved with faking a death usually are illegal. One of the main reasons people will fake their death is because they are avoiding criminal charges. So if you are fleeing a jail sentence, that's obstruction of justice. If you're going to commit identity theft—or any kind of fraud—in your next life, then that's a crime. There is a line you can walk and still stay on the legal side of things, but it's very, very narrow.

Are there famous cases where someone managed to do this? There's a really great case about this out of Germany. Her name is Petra Pazsitka. In the early 80s, she was a young computer-science student at a local university. She was 18 or 19 years old. One day, she just got on the bus and never came back. A few years later in the same area, there was a murder of another teenage girl, slightly younger—like 14 or 15. They found the guy who murdered that young woman, and for some reason, he copped to murdering Petra as well, so she was declared dead. Case closed. In the fall of 2015, there was a call to the police in a different German town to report a burglary. They showed up, and she gave the name Petra Schneider. They said, "You need to show us ID." At that point, she said, "Remember that murdered girl back in the early 80s? That's me."

It's odd how it worked out. Someone else faked her death for her, and they don't appear to have colluded. While she was disappeared for 30 years, she worked completely off the books, she never got another ID, got paid all cash. When this all came out, the German authorities just made her register herself as "alive." But there was no criminal activity that they could find.

So a successful death faker would likely not be living very glamorously. It takes a lot of thought, and you just have to be able to live very modestly. The second you even try to get a library card in someone else's name you're committing fraud. Small amounts of cash, not too much moving around, or you'd have to be showing ID in different places. So it sounds kind of boring when you think about it, but I do think it is possible.

Do cases other than insurance fraud get investigated? If pseudocide is not illegal per se, is anyone verifying these deaths? Unfortunately, law enforcement is usually stretched pretty thin. Even Sam Israel, when he was on the lam, it's not like there were feds searching high and low for him. He saw himself on America's Most Wanted when he was hiding out, which is crazy to think about.

Insurance companies, on the other hand, do have the resources to make sure they are not paying out [to someone who isn't actually dead]. Their burden of proof is not to show that you're alive; it's to show that you're not dead. They don't have to find you, but they have to prove that the documents you submitted were false, that this witness's testimony was bullshit, whatever.

In the book, you spoke to several individuals involved in either catching death fakers or in assisting them—all of whom said faking your death is generally a bad idea. Why is that? They did have a very visceral repulsion to the whole idea. Especially the fraud investigators. They've just dealt with so many knuckleheads over the course of their career. Most of the fraud that they investigate—especially for insurance—is just really easy to spot.

But I think the main reason I was constantly being dissuaded from this idea was because it's just not a super effective way to disappear. It introduces a whole new level of complexity unless you take a lot of time to plan it and plan for the future—which, again, most people who are considering faking their death, are not in a mind frame to really be deliberate and think through the whole plan.

You faked your own death, for the book. How did you do it? I wanted to see how far I could get, short of actually trying to commit fraud. I went to the Philippines because it kept coming up since the beginning of my reporting as the place where a lot of insurance-fraud attempts come from. It's a place with a very robust infrastructure for supporting these frauds in the form of black-market morgues. You can find a body to cremate and pass off as your own. They sell full on "death kits."

What's a "death kit"? Basically anything you'd need to fake your death. Your death certificate, your statements from witnesses who saw your "accident," the fake autopsy report.

I found two incredible local guys there who helped me obtain my own death certificate from a mole they have working inside one of the government agencies. It was based on a false police report with fake witness names making fake witness statements detailing my [traffic] accident. That's how I did it. But I never filed a report with the US Embassy to make it official. Death fraud for life insurance purposes is really carried out with documents, more than anything.

It would have cost $500; probably cheaper [if I'd given them more advance notice]. It was much easier than I thought it would be.

What are the most common mistakes people make in getting caught? Any kind of water accident. We think if you're gonna fake a death, there's the problem of the body. What do you do? "Oh, of course the body will just sink to the bottom of the ocean, and you're good." That's really just not the way it works. Most bodies are recovered within a few days to a week. I spoke to [VICE contributor] Seth Ferranti for another book I'm writing. He staged his death as a suicide. They actually dredged the river looking for his body. So we think that's a really genius Jason Bourne move, but it's actually amateur hour.

Also, being unable to cut ties. That's a perennial problem. I thought that technology would be the biggest stumbling block that you would face in faking your death, but it's actually really being able to truly abandon your old life and your old profile of your likes and dislikes and preferences. Really, just be born a totally new creature. Unfortunately, unless you're kind of a total sociopath, that's really impossible for most people.

Follow Simon Davis on Twitter.

[dipikazz]

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[stari-hun]

I think the 15 is def for if Vertin encounters more humans she needs to save, and she's using Schneider as a marker for how many umbrellas she needs to save an entire family. Kakania doesn't show up in Arcanist in a Nutshell with an umbrella despite likely going to Vertin's team after she was retrieved (idk about her character story yet).

So

Have y'all thought about how Vertin asked for 15 equlibrium umbrellas?

Well, Schneider had 12 sisters and 2 parents.

1+12+2=15

She wants to make sure she can save them all if she ever sees them again. Your welcome.

*posts this and runs*

[gabi-toma]

I wanted to see how the Schneider acrylic markers perform on fabric so I decided to use them on a tote bag. Here is a short process video of me drawing what else but a cat 😂

I wanted to do a super simple design because a more complex one would have had a longer drying time. After finishing it I ironed the bag (on both sides) and I also washed it at 40 degrees Celsius. The colors faded a bit but still look nice (I think 30 degrees Celsius would have been a better choice), but the tote shrunk by 15% 😂😂😂 (wasn't expecting that).

All in all it was a fun process.

[adellaashawk]

🇮🇹 Dovrei vergognarmi dalla frequenza dei miei post? Sì. Ma dopo il Lucca Comics, che per me è super stressante, in cui ho ottenuto un pennarellino Schneider aggratis, disegnare viene molto più naturale.

Feat: 1. Michi che se la prende col papa, 2. Raff, che nella mia testa è stato e sempre sarà un fashionista, si becca gli insulti (con amore), 3. Raff a cavallo (è la prima volta che disegno un cavallo da SECOLI, grazie Pinterest).

🇬🇧 Should I be ashamed by the frequency of my posting? Yes. But, after Lucca Comics (the biggest comicon in Italy, the most stressful event of my year) in which I got a Schneider marker for free, drawing seems so much fun.

Feat: 1. Michelangelo getting angry at the pope ("The pope?! I'll show it to the pope!"), 2. Raffaello/Raphael, who has always been a fashionista in my head, that gets insults in a lovely way ("People keep calling you 'fashionista', I don't know what that means, but I'll use it as an insult, sounds good?), 3. Raffaello on a horse (I haven't drawn a horse in CENTURIES).

[johnschneiderblog]

Yard ornament

Long before we set up camp on this shoreline, somebody - either a person who lived here, or next-door - decided to create a permanent property marker.

Buried beneath this metal pole is what I estimate to be 2.5 cubic buttloads of concrete. I base this on our exertions trying to remove it, and upon the fact that it has stood through all the low-water/high-water cycles nature could dish out over 30 years.

Even though it’s been in the periphery of our vision for all that time we decided only this spring that it had to go. “Have at it,” said the man who lives on the other side of the property line. 

So, over the weekend, Sharon and I dug and dug and dug. We pushed, pulled, kicked, cussed and cursed .... It barely budged.

Then we started thinking ... Maybe the person who worked so hard to make the marker permanent had a point; maybe it will prove to be an invaluable reference to a future property survey.

So, Sharon strapped a sunflower to it. We’ll call it a yard ornament.

[samyrandomness-blog]

A girl and her first pokemon! Sooo cuttteee!! Love love love ittt! Holy crap!!!

[interorbitalteeth]

Marker portrait of Luther Hargreeves kissing his boyfriend, @startrekfemme‘s Zed Schneider. Yes, Luther is gay, no, I won’t elaborate.

[notafraidofredyellowandblue]

Montreal 2022-08-21 Crowdboating

from yt channel Alejandro Rozo

First and foremost: no mic-stands were harmed in the making of this post 😊 Till thanked the crowd very lovingly and stayed away from the mics 😊

Paul decided to sneak up on Schneider

"Hey! No tickling!"

Schneider gives the "Let's go" (any excuse to post that top 😊)

Flake is determined to remain standing

Paul is in his element today, greeting the crowd

Dramatic depiction of guitarist sailing away

...and playing air-guitar.. (and Olli is...Olli 🍀)

Richard...well, he had trouble with his marker (wonder if Joe Letz is still there to hand him his stuff)

...and Richard's boat sways a long way away, so the others have to wait again, Paul taps his sign to make sure Richard knows he's 'Wilkommen' on stage 😊

[gotankgo]

«The Smart Studios Story is a 2016 documentary film written, directed and co-produced by Wendy Schneider. The film chronicles the history and impact of Madison, Wisconsin-based recording studio Smart Studios, founded by Butch Vig and Steve Marker in 1983.»

streaming for free today

[namii-pisces]

I recently started drawing again and this is my most recent work ☺ I know there are a few details that aren't completely the same as the original, but I'm still practising! 😊 please tell me what you think, so I know what details I should work on more :3

[airmanisr]

Supermarine S.6A ‘N248’ by Alan Wilson Via Flickr: c/n unknown. Built in 1929 as a Supermarine S.6 and entered in the 1929 Schneider Trophy race. She was disqualified for turning inside a marker, but still set world records for closed circuits of 50 and 100km. For the 1931 race she was rebuilt with new floats and a bigger engine and was redesignated as an S.6A. She did not take part in the event, being kept in reserve, although the S.6Bs ‘N1595’ and ‘N1596’ were successful in winning and retaining the title as well as setting a world airspeed record. N248 was falsely marked as N1596 for many years, but returned to her correct markings for the opening of the Southampton Hall of Aviation in 1983. Solent Sky, Southampton, Hampshire, UK 21st August 2020