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[biofillermakerhs]

Plasma filler para relleno, modelado y regeneración tisular. El BIOFILLER MAKER Hs, te permite obtener un producto estable, consistente, Biológicamente activo que le garantiza a tus pacientes resultados inmediatos y permanentes. Los profesionales de la Estetica lo prefieren! . . #plasmafiller #plaquetas #plasmade4tageneración #prp #fillerlabios #termogel #plateletrich #clinicaestética #lips #glúteos #arrugas #biofillermakermachine #estéticachile #rellenodelabios #rejuvenecimientofacial #rellenofacial https://www.instagram.com/p/B_GBhdiHred/?igshid=dmhqferm9xdh

[luxemdaesthetics]

Luxe MD Aesthetics: Your Skin, Hair, and Body Expert

Luxe MD Aesthetics is a boutique style medispa offering state of the art technology services ranging from Injectables, wellness, skincare, laser treatments, body, and more. At Luxe MD Aesthetics our cosmetic expert and experienced doctor, Dr. Bikas Shamrma provides the best service by catering to the needs of every patient and offers a combination of treatments that best suit the patients. We also provide the best plateletrich plasma facial rejuvenation treatment in Las Vegas.

If you are looking for a cosmetic expert who can help you reach your goals in terms of skin, body, wellness, etc, Dr. Bikas Sharma is your best choice. Our cutting edge devices are researched and selected to provide effective and lasting results to our patients. We treat an array of concerns ranging from face and hair to the body. We strive to give our patients customized procedures in a comfortable and welcoming environment. During the first consultation, Dr. Bikas Sharma will talk to you to understand your requirements and explain to you the procedures that need to be followed.

Under the range of treatments offered here at Luxe MD Aesthetics, platelet rich plasma for hair restoration treatment is also one of the best services in Las Vegas. Under this treatment a small amount of your blood is drawn and placed in a centrifuge for processing. The centrifuge separates the blood into distinct layers containing various concentrations of red blood cells, white blood cells, and platelets. The layer of plasma that is rich in platelets is then collected and injected back into your body in the affected area, where it can stimulate your natural regenerative processes.

You can also consult Dr. Bikas Sharma for a medically supervised weight loss program, that has effective results and has gained appreciation from patients across the nation. Book your appointment today!

Original Source: Blogger.com

[cushydiet-blog]

Sports hype of platelet-rich plasma 'powerful marketing tool' but distorts the science - Health - http://wp.me/p8IYwe-6s9 - #Distorts, #Health, #Hype, #Marketing, #Plasma, #Plateletrich, #Powerful, #Science, #Sports, #Tool, #World_News

[andrewfact-blog]

Global Bone Growth Stimulator Market Dynamics: Trends, Supply Chain, Cost Structure, Revenue worth US$ 1,477.2 Mn in 2017

A fresh study, covering “Bone Growth Stimulator Market Forecast, Trend Analysis & Competition Tracking: Global Review 2017 to 2022” has been broadcasted to wide online repository of Fact MR, which presents deep focus on the Healthcare Market. This smart study contains precise data that offers a clear insight about market current scenario and future projections for the benefit of readers. Moreover, the study enclosed significant data which tends to make the research a powerful source for analysts and industry experts who are looking to gain necessary knowledge about the prevailing market trends, opportunities and drivers present in the Bone Growth Stimulator Market.

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Rise in R&D Funding by Private Organisations to Propel Growth of the Global Bone Growth Stimulator Market

Bone growth stimulators facilitate multi-level fusions in bones with high efficiency, playing a pivotal role in spine fusion aftercare of patients. Medical studies are revealing positive outcomes of utilizing electrical bone growth stimulators for spinal fusion process. With a number of favorable government initiatives, coupled with heavy investments made by several private organisations, there has been a robust increase in research & development activities associated with new treatment methods and product development. For example – the North American Spine Foundation, and American Academy of Orthopedic Surgeons are contributing to the development of spinal implants & devices by raising funds for R&D activities, and conducting training programs for physicians worldwide.

Leading players in the market have introduced novel bone growth stimulators in order to cater demand from soaring adoption of affordable minimally-invasive surgeries (MIS). Orthofix, a Texas Company, has introduced new bone growth stimulators, the CervicalStim and the SpinalStim, which have been approved by the European CE Mark as well as the Food and Drug Administration of the U.S. While the out-of-the-office treatment option (non-invasive) has an obvious appeal to it, necessary patient compliance remains a challenge for physicians. However, an application called Stim onTrack has been developed by Orthofix, which offers physicians with real-time data, which enables effective detailing of the patient’s treatment protocol.

North America to Remain Dominant in the Global Bone Growth Stimulator Market

North America will continue to be dominant in the global bone growth stimulator market. Sales of bone growth stimulators are expected to account for the largest revenues in North America, expanding at the highest CAGR through 2022. Europe will remain the second most lucrative market for bone growth stimulators. The market in Middle East & Africa (MEA) will continue to register a sluggish expansion through 2022.

Bone growth stimulation devices will remain sought-after among products in the global market. Revenues from sales of bone growth stimulation devices will account for over half share of the market during the forecast period. In addition, sales of platelet-rich plasma bone growth stimulator, and bone morphogenetic proteins are expected to exhibit the fastest expansion registering similar CAGRs through 2022.

Hospitals & Clinics will Remain the largest End-Users of Bone Growth Stimulators

Based on end-users, sales of bone growth stimulators in academic and research institutes are expected to register the highest CAGR through 2022. Hospitals & Clinics will continue to be the largest end-users of bone growth stimulators, accounting for the highest share of the market over the forecast period. Home care is expected to remain the second most lucrative end-use segment in the global bone growth stimulators market.

Bone growth stimulators are expected to find the largest application in the cases of delayed union & non-union bone fractures, with sales poised to reach US$ 763.4 Mn by 2022-end. Sales of bone growth stimulators in oral & maxillofacial surgeries will account for the lowest revenues during the forecast period, based on application.

Browse Full Report With TOC- https://www.factmr.com/report/54/bone-growth-stimulator-market

Table of Content

Chapter 1. Global Bone Growth Stimulator Market - Executive Summary. 12

Chapter 2. Global Bone Growth Stimulator  Market Overview. 14 2.1. Introduction. 14        2.1.1. Global Bone Growth Stimulator Market Taxonomy. 14        2.1.2. Global Bone Growth Stimulator Market Definition. 14 2.2. Global Bone Growth Stimulator Market Size (US$ Mn) and Forecast, 2012-2022. 15        2.2.1. Global Bone Growth Stimulator Market Y-o-Y Growth. 15 2.3. Global Bone Growth Stimulator Market Dynamics. 15        2.3.1. Drivers. 15        2.3.2. Restraints. 15        2.3.3. Trends. 16 2.4. Supply Chain. 16 2.5. Cost Structure. 16

Chapter 3. Global Bone Growth Stimulator  Market Analysis and Forecast By Product. 17 3.1. Global Bone Growth Stimulator Market Size and Forecast By Product, 2012-2022. 17        3.1.1. Bone Growth Stimulation Devices Bone Growth Stimulator Market Size and Forecast, 2012-2022. 17                 3.1.1.1. Revenue (US$ Mn) Comparison, By Region. 17                 3.1.1.2. Market Share Comparison, By Region. 19                 3.1.1.3. Y-o-Y growth Comparison, By Region. 19        3.1.2. Platelet-Rich Plasma Bone Growth Stimulator Market Size and Forecast, 2012-2022. 20                 3.1.2.1. Revenue (US$ Mn) Comparison, By Region. 20                 3.1.2.2. Market Share Comparison, By Region. 22                 3.1.2.3. Y-o-Y growth Comparison, By Region. 22        3.1.3. Bone Morphogenetic Proteins  Bone Growth Stimulator  Market Size and Forecast, 2012-2022. 23                 3.1.3.1. Revenue (US$ Mn) Comparison, By Region. 23                 3.1.3.2. Market Share Comparison, By Region. 25                 3.1.3.3. Y-o-Y growth Comparison, By Region. 25

Continue…..

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[serenavangstuff]

JuniperPublishers-What Ages First: Pulp or Dentin? Journal of Gerontology and Geriatric Medicine-Juniper Publishers

Abstract

Dental pulps stem cells have regeneration potentials. Young pulp cells convert when they mature into cell-producing dentin. In the pulp, the targeted cells are specifically pulpoblasts, fibroblasts, immune and inflammatory cells. In the coronal part of the teeth, capillaries irrigate 100-150 m round or oval domains, allowing the cleaning of continuous zones. In the root, an uninterrupted fish net-like arrangement is located at the periphery of the dental pulp. Thrombus leads to degenerative processes, or to pulp degradation. Pulp necrosis, apoptosis, or nemosis guide pulp impairment. They may influence pulp renewal. Stem cells include Dental Pulp Stem Cells (DPSCs), Exfoliated Deciduous Teeth Stem Cells (SHEDs), Platelet Derived Growth Factors (PDLSCs), Dental Follicle Precursors (DFSCs) and Apical Papilla Stem Cells (SCAPs). An ascending layer of cells issued from the apical papilla mesenchyme contributes to pulp regeneration. Initially, apical cell-rich zones are undifferentiated, and cell sliding involves the transfer from the apical part of the root to the crown, moving from the sub-odontoblastic layer to the radicular dental pulp. Linked by intercellular junctional complexes, pulp cells are interconnected by gap- and tight- junctions. They are transported toward the crown, tightly associated by intercellular junctions. In addition, lateral sliding occurs between the mesial cavities and the central pulp. Later, translocation takes place between the central pulp and the distal horn. This is obvious after an injection with Bio (a Glycogen Synthase Kinase-3 specific inhibitor implicated in regenerative medicine). After a single injection, labeled cells become scarce and in the apical papilla mesenchyme, cells slide laterally from the mesial to the distal pulp horn, where they become undetectable. As pulp cells become older, VEGF promotes blood vessel formation. The activation of the ERK pathway leads to the expression of osteogenesis-related genes, such as Cbfa1, Col I, ALP, and OCN, responsible for dentin formation and mineralization of extracellular matrix components (Tables 1 & 2). TNF-α, Notch, p38 MAPK, TGF-β, Msx1, Msx2, and JNK signaling pathways are implicated in osteogenic differentiation. Dental pulp cells, young and/or old odontoblasts/osteoblasts contribute to bone and dental tissues regeneration. Adipose tissue is another source of mesenchyme stem cells. Young pulp cells become older, producing a dentin layer that contribute efficently to geriatric odontology.

Keywords: Pulp; Dentin; Stem Cells; A Mini-Review.

Abbrevations: DPSCs: Dental Pulp Stem Cells; SHEDs: Exfoliated Deciduous Teeth Stem Cells; PDLSCs: Platelet Derived Growth Factors; DFSCs: Dental Follicle Precursors; SCAPs: Apical Papilla Stem Cells; ASCs: Adipose-Derived Stromal/Stem Cells; OPN: Osteopontin; OCL: Osteocalcin; ECM: Extracellular Matrix Components; ALP: Alkaline Phosphatases

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Introduction

Deep carious lesions lead to irreversible pulp damage. Stem cells located in dental pulps replicate and retain potentials for regeneration [1-12]. They are implicated in the repair of defective cell types, carious lesions and genetic therapies. After the formation of a thin outer mantle dentin, a thick circumpulpal dentin is created, including the primary and secondary dentins orthodentin (tubular dentin) and osteodentin, which are developed long after the pulp formation. Reparative (or tertiary) dentin is formed after a pulp horn exposure (Figure 1).

In the pulp, the targeted cells are specifically pulpoblasts, fibroblasts, immune and inflammatory cells. Different groups of cells are concerned by pulp regeneration. They include odontoblast-like cells, a whole collection of immune cells, central and peripheral nerves, ending at close vicinity of odontoblast cell bodies. Odontoblasts involve the Raschkow’s sub-odontoblastic network. Vascular and lymphatic vessels recolonize and irrigate the wounded pulp tissue [13,14]. Altogether, these cells play a role in pulp physiology, including functionality within the central pulp (Figure 2).

In the coronal part of the teeth, capillaries irrigate 100-150 m broad domains, round or oval areas, allowing the cleaning of continuous adjacent zones [15,16]. Along the periphery of the pulp, capillaries allow peripheral vascularization and this distribution favours pulp regeneration. In the middle of the pulp, arterioles and venules are in continuity and contribute to stimulate pulp regeneration. In the root part, a fish net–like arrangement is continuous at the periphery of the dental pulp. Thrombus leads to degenerative processes, and ultimately to pulp degradation. Pulp necrosis, apoptosis, or nemosis leads either to the totality of pulp degradation, or specifically allows pulp renewal [17,18] (Figure 3).

In contrast, the formation of dentin implicates a series of molecules (Table 2). Mineralizing molecules are including adiponectin, type I collagen, alkaline phosphatase, DMP- 1, 1-dentin sialoprotein, dentin sialoprotein and dentin sialophosphoprotein, MEPE, dentin matrix metalloprotease MMP-3, MMP-9, PGs (decorine, biglycan, osteoadherin, fibromodulin) and osteopontin [19-22]. To conclude with the construction of dental tissues, first a dental pulp is formed, and later a dentin layer is deposited along the initial layer of mantle dentin (orthodentin and osteodentin). At the periphery of the pulp, odontoblasts polarize and differentiate (Figure 4).

The prevalence of caries is rather high (about 85% in the 65-74 year-old patient) and significant in the aging population. In younger patients, the 35-45 year-old group of patients, the carious prevalence is limited to 80.2%. Pulp inflammation is lower in young patients and higher in the older patient group. In this clinical context, a significant impact is related to the aging pulp.

Pulp stem cells constitute a heterogeneous population. In dental tissues, stem cells include 1) dental pulp stem cells (DPSCs), 2) exfoliated deciduous teeth stem cells (SHEDs), 3) platelet derived growth factor (PDLSCs), 4) dental follicle precursors stem cells (DFSCs) and 5) apical papilla stem cells (SCAPs). Adipose-Derived Stromal/Stem Cells (ASCs) play crucial role in the treatment of craniomaxillofacial defects [23]. ASCs are committed toward an osteogenic phenotype. Angiogenesis and osteogenesis support bone regeneration. Plasma membrane-derived vesicles are important mediators in cell-to-cell communication. Growth factors, cytokines, RNAs and microRNA perform biological activities on target cells. They activate regenerative or reparative processes [18]. Bioengineering teeth may be obtained from cultured tooth bud cells [24,25] (Figures 5 & 6).

ASCs derived from pulp donors showed a high expression of osteogenic markers. This is the case for Osteopontin (OPN), Osteocalcin (OCL), and BMP-2. A high mineral content is found in the pulp and dentin of old patients [1,9,21,26] (Figure 7).

Pulp regeneration implies a cascade of cells, sliding from the apex toward the upper part of the crown. In the apical part, undifferentiated cells contribute to colonize the root. The ascending cells move beneath the odontoblast layer, and form a continuous layer that will further colonize the sub-odontoblastic layer. They proliferate, multiply and concentrate in the apical cell-rich zone. In the root, cell sliding starts near the apical part. The ascending layers of cells contribute to pulp regeneration [24,25] (Figure 8).

Initially, pulp cells are undifferentiated, and move from the sub-odontoblastic layer to the collar of the tooth. Presumably, cell sliding involves an ascending transfer from the apical part of the root toward the crown [27,28].

Connected by intercellular junctional complexes, namely desmosome-like junctions, pulp cells are linked by gap- and tightjunctions and they move simultaneously. They are transported along an ascending way, tightly connected by intercellular junctions. They move from the central part of the root to the periphery of the crown where they fan out [29-32] (Figure 9).

In addition, lateral sliding is occurring between mesial cavities prepared after drilling, and the central pulp horn. Afterward, translocation occurs between the central horn and the distal pulp. This is noticeable mostly for rats injected with Bio (a Glycogen Synthase Kinase-3 specific inhibitor implicated in regenerative medicine [32]). After a single injection, labeled cells become scarce in the mesial part of the pulp and they are grouped in the central pulp area. Bio-labeled cells located beneath the odontoblast layer are less numerous in the distal pulp. It comes out that cells slide laterally from the mesial pulp to the distal pulp horn whereas sliding becomes undetectable in the distal part of the pulp.

The conclusions that arise from these experimental approaches are 1) that cells slide in an ascending way from the apex toward the crown, 2) afterward, lateral sliding occurs between the mesial horn and the central/distal pulp. This evolution takes place mostly in the coronal pulp, leading to the terminal differentiation of odontoblasts. In addition, terminal differentiation was strongly linked to the strategic mesenchymal stem cells that are implicated in dentinogenesis, and angiogenesis. Pulp cells are implicated in the implantation of bioactive molecules located in the root, within the dental pulp (Figure 10).

Pulp cells are implicated in geriatric odontology. Angiogenesis shows vascular endothelial growth factor, as well as platelet-derived growth factor, and hepatocyte growth factor. IGF-1, VEGF-D and interleukine-8 improve the recruitment of undifferentiated and/or hematopoietic stem cells associated to different tooth compartments [31]. Combined with biomaterials, such as -tricalcium phosphate, bioactive glass and plateletrich plasma, the dental pulp or bone tissue display potential in pulp regeneration. Pulp renewal is also dependent of adiposederived stromal /stem cells (ASCs).

As cells become older, VEGF promotes new blood vessel formation, and they are also able to recruit hematopoietic stem cells. The activation of the ERK pathway in ASCs leads to the expression of osteogenesis-related genes, such as Cbfa1, Col I, ALP, and OCN, which appears to be responsible for pulp mineralization of Extracellular Matrix Components (ECM) [21,23,26,29,30,31].

As a conclusion, TNF-α may enhance the osteogenic differentiation of ASCs by increasing specific gene expression, such as osteopontin (OPN), runx-related transcription factor 2 (RUNX-2), and Alkaline Phosphatases (ALP) (Tables 1 & 2) [11]. Molecular investigations clearly confirmed that ERK, TNF-α, Notch, p38 MAPK, TGF-β, Msx1, Msx2, and JNK signaling pathways are strongly implicated in the odontogenic/osteogenic differentiation of ASCs [31-36].

Conclusion

Altogether, young and old dental pulp cells, young and old odontoblasts and osteoblasts contribute to bone and dental tissues differentiation/regeneration. Adipose tissue is an active source of mesenchyme stem cells. Noticeably, aging tissues contribute efficiently to geriatric odontology.

To read more articles in Journal of Gerontology & Geriatric Medicine

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[dynamicosteopaths]

‪Platelet-Rich Plasma Therapy - The Secret To Youthful, Beautiful Skin‬ ‪ https://www.dynamicregenmedicine.co.uk/single-post/2017/12/01/PlateletRich-Plasma-Therapy-The-Secret-To-Youthful-Beautiful-Skin #Prp #VampireFacelift #Birmingham #Skin‬ #Treatments #Rejuvenation #SkinTreatment #PlateletRichPlasma #Botox #Fillers #Face #Wrinkles #Eyebags #Tone #Complexion #Leamington #Affordable #Warwick #HenleyInArden #Benefits #Results

[luxemdaesthetics]

Aesthetics treatments at Luxe MD Aesthetics

Luxe MD Aesthetics is a renowned medispa in Las Vegas, offering the best aesthetic treatment. From plateletrich plasma for hair restoration,laser genesis rosacea, and wrinkle treatment to fillers, injectables, and wellness treatment everything is offered here. We, at Luxe MD Aesthetics, cater to our patients to give them customized procedures in a comfortable and welcoming environment.

Dr. Bikas Sharma is a well-known cosmetic physician offering the best preventative care while encouraging patients to get healthy. He also encourages the use of alternative medicine and follows an integrated approach. If you are looking for any kind of aesthetic or cosmetic treatment, Luxe MD Aesthetics is the best choice you can ever make. We provide high-quality effective treatment at the best prices. If you are looking for effective treatment of dysport in Las Vegas, book a consultation with Dr. Bikas Sharma. He is a prized physician who has won many honors and testimonials over the years and can treat you in the best possible way.

The treatment through Neuromodulators specifically targets lines on the face that are caused by muscle movement, called “dynamic wrinkles.” Dynamic wrinkles become deeply ingrained on the face over time due to repetitive movements and facial expressions. For Dysport, the formulation differs from Botox, which allows for it to spread more easily. This means it’s a great treatment for wider areas where wrinkles are present, such as the forehead. Hence we also carry the neuromodulators Xeomin and Dysport along with the most common neuromodulator Botox.

Along with Testosterone replacement therapy, female hormone replacement therapy, we also offer a medically supervised weight loss program, at Luxe MD Aesthetics. These programs typically offer a variety of services that approach weight loss and weight management from different angles, such as nutrition plans, physical activity recommendations, and prescription medications.

Book your appointment today!

Original Source: Blogger.com

[cushydiet-blog]

Sports hype of platelet-rich plasma 'powerful marketing... - http://wp.me/p8XyML-3eP - #Hype, #Marketing, #News, #Plasma, #Plateletrich, #Powerful, #Sports

[dynamicosteopaths]

‪Platelet-Rich Plasma Injection Alleviates Low Back Pain Involving Sacroiliac Joint‬ ‪ https://www.dynamicosteopaths.com/single-post/2017/11/23/PlateletRich-Plasma-Injection-Alleviates-Low-Back-Pain-Involving-Sacroiliac-Joint #prp #birmingham #treatment ‬#like4like #PlateletRichPlasma #injection #osteopath #chiropractor #solihull #birmingham (at Tudor Grange Leisure Centre)

[dynamicosteopaths]

‪Platelet-Rich Plasma (PRP) in Sports Medicine‬ ‪ https://www.dynamicregenmedicine.co.uk/single-post/2017/10/18/PlateletRich-Plasma-PRP-in-Sports-Medicine #prp #sportsinjury #birmingham #solihull #osteopath #jointpain ‬ (at Barnt Green)