#pharmaceutical product testing

[itclabs]

Drug & Pharmaceutical Product Testing & Analysis Services in India

Looking for reliable pharmaceutical product testing and drugs testing services in India? ITC Labs offers comprehensive pharmaceutical testing services to ensure the quality, safety, and compliance of your products. As a leading pharmaceutical testing lab, we provide advanced solutions for pharmaceutical analysis testing and pharma testing services. Whether you need testing for drugs or quality assurance for pharmaceutical products, our NABL-accredited pharmaceutical analysis lab delivers accurate, timely results to meet all regulatory standards.

[nickala]

"To our knowledge, no previous studies have measured metals in tampons."

This is the sticking point for me, and this is absolutely what we should be talking about. No previous studies? Really??? This isn't the standard for whatever QA/QC department that measures this stuff before releasing manufacture batches to the public?

Demand better standards for menstrual products.

This should not be a first-of-its-kind study with a tiny sample size! This should be what the manufacturers are required by law to test for before their product can go on shelves! Public health organizations need to set a maximum PPB level!

this post is fearmongering. the results of this study are concerning and should definitely be a matter of public discussion, but this is certainly not the conclusion the researchers came to.

the point of the study was to assess the risks of exposure to toxic metals- something one of the co-authors notes are “ubiquitous” fwiw- via menstrual products. Their research confirmed that these metals are indeed present in tampons, but no further conclusions are drawn. it is possible the metal entered into the cotton from the soil, which is a well-known phenomenon; cotton is so good at lifting heavy metals that it has actually been suggested as a part of the solution for revitalizing polluted ground.

the authors conclude with an acknowledgement that the study should be repeated- their sample size was 60 tampons- and a suggestion that further testing ought to be done to indicate whether or not these metals can even leech out of the tampon in the first place, let alone whether or not such leeching could occur at levels deleterious to human health.

there is, in fact, a body of research- too small, for sure, but much larger than this single study- indicating that long-term proper tampon use has no observable negative impact on health. i am grateful and thrilled that more research is being done and i hope that this study is the first of many on this line of questioning, but i am really frustrated at this post and the response it got.

obviously, if this study alters your approach to menstrual health, more power to you. consumers should be informed-risk-takers, and menstrual health is double-obviously a very personal choice. but it definitely wasn't the researchers concluding that you ought to “avoid using tampons at all cost," only this tumblr user did. the lead author of the paper, in fact, specifically says that she hopes people do NOT panic about the results.

(the notes of the post were disappointing. people affirming that they knew they were right to be suspicious of tampons all along, or even recommending alternatives that actually have very little to no research regarding the safety of long-term use, etc. it’s a different conversation, but categorical distrust of tampons is old-school misogyny. you certainly shouldn't wear them if you don’t want to, but there is nothing inherently scary or wrong about them, and people who prefer them are not being reckless or crass.)

((if you're really worried about exposure to heavy metals, you may want to turn a critical eye to fast fashion, as an aside))

[thoughtportal]

Opinion Here’s how to get free Paxlovid as many times as you need it

When the public health emergency around covid-19 ended, vaccines and treatments became commercial products, meaning companies could charge for them as they do other pharmaceuticals. Paxlovid, the highly effective antiviral pill that can prevent covid from becoming severe, now has a list price of nearly $1,400 for a five-day treatment course.

Thanks to an innovative agreement between the Biden administration and the drug’s manufacturer, Pfizer, Americans can still access the medication free or at very low cost through a program called Paxcess. The problem is that too few people — including pharmacists — are aware of it.

I learned of Paxcess only after readers wrote that pharmacies were charging them hundreds of dollars — or even the full list price — to fill their Paxlovid prescription. This shouldn’t be happening. A representative from Pfizer, which runs the program, explained to me that patients on Medicare and Medicaid or who are uninsured should get free Paxlovid. They need to sign up by going to paxlovid.iassist.com or by calling 877-219-7225. “We wanted to make enrollment as easy and as quick as possible,” the representative said.

Indeed, the process is straightforward. I clicked through the web form myself, and there are only three sets of information required. Patients first enter their name, date of birth and address. They then input their prescriber’s name and address and select their insurance type.

All this should take less than five minutes and can be done at home or at the pharmacy. A physician or pharmacist can fill it out on behalf of the patient, too. Importantly, this form does not ask for medical history, proof of a positive coronavirus test, income verification, citizenship status or other potentially sensitive and time-consuming information.

But there is one key requirement people need to be aware of: Patients must have a prescription for Paxlovid to start the enrollment process. It is not possible to pre-enroll. (Though, in a sense, people on Medicare or Medicaid are already pre-enrolled.)

Once the questionnaire is complete, the website generates a voucher within seconds. People can print it or email it themselves, and then they can exchange it for a free course of Paxlovid at most pharmacies.

Pfizer’s representative tells me that more than 57,000 pharmacies are contracted to participate in this program, including major chain drugstores such as CVS and Walgreens and large retail chains such as Walmart, Kroger and Costco. For those unable to go in person, a mail-order option is available, too.

The program works a little differently for patients with commercial insurance. Some insurance plans already cover Paxlovid without a co-pay. Anyone who is told there will be a charge should sign up for Paxcess, which would further bring down their co-pay and might even cover the entire cost.

Several readers have attested that Paxcess’s process was fast and seamless. I was also glad to learn that there is basically no limit to the number of times someone could use it. A person who contracts the coronavirus three times in a year could access Paxlovid free or at low cost each time.

Unfortunately, readers informed me of one major glitch: Though the Paxcess voucher is honored when presented, some pharmacies are not offering the program proactively. As a result, many patients are still being charged high co-pays even if they could have gotten the medication at no cost.

This is incredibly frustrating. However, after interviewing multiple people involved in the process, including representatives of major pharmacy chains and Biden administration officials, I believe everyone is sincere in trying to make things right. As we saw in the early days of the coronavirus vaccine rollout, it’s hard to get a new program off the ground. Policies that look good on paper run into multiple barriers during implementation.

Those involved are actively identifying and addressing these problems. For instance, a Walgreens representative explained to me that in addition to educating pharmacists and pharmacy techs about the program, the company learned it also had to make system changes to account for a different workflow. Normally, when pharmacists process a prescription, they inform patients of the co-pay and dispense the medication. But with Paxlovid, the system needs to stop them if there is a co-pay, so they can prompt patients to sign up for Paxcess.

Here is where patients and consumers must take a proactive role. That might not feel fair; after all, if someone is ill, people expect that the system will work to help them. But that’s not our reality. While pharmacies work to fix their system glitches, patients need to be their own best advocates. That means signing up for Paxcess as soon as they receive a Paxlovid prescription and helping spread the word so that others can get the antiviral at little or no cost, too.

{source}

[chemxpert]

Understanding Drug Master File (DMF) for Corticosteroids

Pharmacovigilance companies play a crucial role in ensuring the safety of corticosteroids, with specialized pharmacovigilance services tracking adverse effects. Pharma software companies support this effort by providing advanced tools for data management and regulatory compliance. Understanding the Drug Master File (DMF) for corticosteroids is essential for maintaining high standards in drug safety and efficacy. These collaborations ensure comprehensive oversight and enhance patient safety.

[animal-care]

Expanding Opportunities in the Animal Health Market: Trends and Outlook

Introduction

The Animal Health Market is witnessing dynamic growth and evolution, fueled by changing consumer preferences, advancements in veterinary medicine, and increasing awareness of animal welfare. In this blog, we explore key trends shaping the animal health industry and provide insights into the market's outlook for the future.

Rise of Pet Ownership

One of the most notable trends driving the animal health market is the growing popularity of pet ownership. As more people welcome pets into their homes, demand for veterinary services, pet care products, and preventive healthcare measures is on the rise. This trend is particularly evident in urban areas, where pet ownership is becoming increasingly common among young professionals and families.

Focus on Preventive Care

Preventive healthcare has emerged as a key priority for pet owners, leading to increased demand for vaccines, parasite control products, and wellness exams. Veterinarians are increasingly emphasizing the importance of regular check-ups and preventive treatments to maintain pets' health and detect potential issues early. This shift towards proactive healthcare is driving growth in the animal health market.

E-Commerce Boom

The rise of e-commerce platforms has transformed the way pet owners access veterinary products and services. Online retailers offer a wide range of pet care products, prescription medications, and veterinary supplies, providing convenience and accessibility to pet owners. This trend is expected to continue, with e-commerce projected to play an increasingly important role in the distribution of animal health products.

Focus on Animal Welfare

Consumer awareness of animal welfare issues is driving demand for ethically sourced and sustainably produced animal products. This includes pet food, livestock feed, and pharmaceuticals used in animal health care. Companies in the animal health market are responding to these demands by implementing sustainable practices, ensuring the welfare of animals throughout the supply chain.

Technological Advancements

Advancements in technology are revolutionizing the practice of veterinary medicine, with innovations such as telemedicine, digital health monitoring, and artificial intelligence gaining traction. These technologies enable veterinarians to deliver remote care, monitor patients' health in real-time, and make data-driven treatment decisions. As technology continues to advance, it is expected to further enhance the quality and accessibility of veterinary care.

Regulatory Landscape

The Animal Health Market is subject to a complex regulatory landscape, with stringent requirements for product safety, efficacy, and labeling. Regulatory agencies play a critical role in ensuring the quality and integrity of veterinary products and services, safeguarding animal and human health. Companies operating in the animal health market must navigate these regulatory requirements to bring products to market and maintain compliance.

Global Expansion Opportunities

The animal health market offers significant opportunities for global expansion, particularly in emerging markets with growing pet populations and increasing disposable income. Asia-Pacific, Latin America, and the Middle East are emerging as key growth regions for the animal health industry, presenting opportunities for investment and market expansion.

Conclusion

The animal health market is experiencing rapid growth and transformation, driven by evolving consumer preferences, technological advancements, and regulatory developments. From the rise of pet ownership and the focus on preventive care to the adoption of e-commerce and the expansion into global markets, the animal health industry is poised for continued growth and innovation. By staying abreast of key trends and embracing opportunities for innovation and expansion, stakeholders in the animal health market can position themselves for success in this dynamic and evolving industry.

[crop-protection-market]

Exploring the Animal Care Market: A Global View of Share, Growth, and Future Outlook

The Animal Care Market, a domain driven by compassion and dedication, plays a vital role in safeguarding the well-being of our cherished animal companions. This comprehensive overview dives into the intricacies of the Animal Care Market, encompassing analysis, demand dynamics, growth projections, challenges, and emerging trends.

Compassionate Care: Unveiling the Landscape of the Animal Care Market

Beyond being an industry, the Animal Care Market is a testament to our commitment to providing optimal care for our diverse animal companions. Analyzing its multifaceted nature reveals the delicate balance between technological advancements, regulatory compliance, and the unwavering dedication of caregivers. The Global Animal Care Market Size is poised to reach USD 100 billion by 2025, reflecting a compounded annual growth rate of 6%. Notably, the Asia-Pacific region leads the way, holding a substantial 35% share of the total market revenue.

Meeting the Demand: Addressing the Needs of Pets and Livestock

Understanding the demand dynamics within the Animal Care Market is pivotal for stakeholders aiming to cater to the diverse needs of both pet owners and livestock producers. The surge in pet adoption, evolving pet humanization trends, and a growing awareness of preventive veterinary care collectively drive Animal Care Market Demand. Additionally, rising concerns about zoonotic diseases and the push for sustainable livestock practices significantly contribute to the demand for animal health products. Remarkably, pet owners in North America annually invest an average of USD 1,200 in veterinary care and related products.

Forecasting a Brighter Future: Growth and Outlook of the Animal Care Market

Navigating the trajectory of growth and forecasting future trends is essential for stakeholders contributing to the positive development of the Animal Care Market. The Animal Care Market Outlook is optimistic, fueled by sustained demand for advanced veterinary services, pet insurance, and innovative healthcare products. Government initiatives promoting animal health and welfare further contribute to this positive growth outlook. The Latin American region is anticipated to experience the highest growth rate in the Animal Care Market, with a projected CAGR of 8% over the next five years.

Revenue Realities: Illuminating the Financial Landscape of Animal Care

Delving into the revenue aspects of the Animal Care Market unveils the economic viability of the industry and the financial considerations influencing stakeholders. The Animal Care Market Revenue is diverse, spanning veterinary services, pet products, and pharmaceuticals. The uptick in pet ownership, coupled with an increased willingness to invest in premium pet products and services, significantly contributes to market revenue. Veterinary services specifically contribute to 50% of the total Animal Care Market Revenue, showcasing the growing emphasis on professional healthcare for pets.

Sizing Up: Animal Care Market Size and Emerging Trends

Analyzing the size of the Animal Care Market alongside emerging trends provides a comprehensive view of the industry's current state and future possibilities. The Animal Care Market Size is witnessing a surge in demand for organic and natural pet care products. Notably, e-commerce platforms are gaining popularity for purchasing pet products, reflecting shifts in consumer buying behavior. Online sales of pet care products have witnessed a substantial 25% year-on-year increase, signaling the digital transformation of the Animal Care Market.

Challenges on the Horizon: Navigating Animal Care Market Challenges

While the Animal Care Market thrives on compassion, it is not immune to challenges that demand thoughtful solutions. Animal Care Market Challenges include regulatory complexities, the increasing need for skilled veterinarians, and ethical considerations surrounding animal testing. The rise in counterfeit animal health products poses a significant challenge to the integrity of the Animal Care Market. The shortage of skilled veterinarians, estimated at 20% in developing regions, impacts the accessibility of veterinary services.

The Ever-Changing Landscape of Animal Care Market Trends

Remaining at the forefront of the Animal Care Market involves a keen awareness of emerging trends shaping the industry's future. Animal Care Market Trends include the rising demand for personalized pet nutrition, the integration of telehealth services in veterinary care, and the growing popularity of pet wearables. Sustainable and eco-friendly practices are gaining prominence, with consumers seeking ethically sourced and environmentally conscious animal care products. The market for pet wearables is expected to witness a remarkable CAGR of 12% over the next five years, driven by the increasing focus on pet health monitoring.

Conclusion: A Commitment to Compassion and Innovation

The Animal Care Market stands as a testament to our unwavering commitment to the well-being of our animal companions. Navigating its complexities requires a blend of compassion, innovation, and a proactive response to emerging trends and challenges. As the market continues to evolve, stakeholders must remain adaptable and dedicated to ensuring the health and happiness of the creatures we cherish.

[afeelgoodblog]

The Best News of Last Week

1. ‘We are just getting started’: the plastic-eating bacteria that could change the world

In 2016, Japanese scientists Oda and Hiraga published their discovery of Ideonella sakaiensis, a bacterium capable of breaking down PET plastic into basic nutrients. This finding marked a shift in microbiology's perception, recognizing the potential of microbes to solve pressing environmental issues.

France's Carbios has successfully applied bacterial enzyme technology to recycle PET plastic waste into new plastic products, aligning with the French government's goal of fully recycling plastic packaging by 2025.

2. HIV cases in Amsterdam drop to almost zero after PrEP scheme

According to Dutch AIDS Fund, there were only nine new cases of the virus in Amsterdam in 2022, down from 66 people diagnosed in 2021. The organisation claimed that 128 people were diagnosed with HIV in Amsterdam in 2019, and since 2010, the number of new infections in the Dutch capital has fallen by 95 per cent.

3. Cheap and drinkable water from desalination is finally a reality

In a groundbreaking endeavor, engineers from MIT and China have designed a passive solar desalination system aimed at converting seawater into drinkable water.

The concept, articulated in a study published in the journal Joule, harnesses the dual powers of the sun and the inherent properties of seawater, emulating the ocean’s “thermohaline” circulation on a smaller scale, to evaporate water and leave salt behind.

4. World’s 1st drug to regrow teeth enters clinical trials

The ability to regrow your own teeth could be just around the corner. A team of scientists, led by a Japanese pharmaceutical startup, are getting set to start human trials on a new drug that has successfully grown new teeth in animal test subjects.

Toregem Biopharma is slated to begin clinical trials in July of next year after it succeeded growing new teeth in mice five years ago, the Japan Times reports.

5. After Decades of Pressure, US Drugmaker J&J Gives Up Patent on Life-Saving TB Drug

In what can be termed a huge development for drug-resistant TB (DR-TB) patients across large parts of the world, bedaquiline maker Johnson and Johnson said on September 30 (Saturday) that it would drop its patent over the drug in 134 low- and middle-income countries (LMICs).

6. Stranded dolphins rescued from shallow river in Massachusetts

7. ‘Staggering’ green growth gives hope for 1.5C, says global energy chief

The prospects of the world staying within the 1.5C limit on global heating have brightened owing to the “staggering” growth of renewable energy and green investment in the past two years, the chief of the world’s energy watchdog has said.

Fatih Birol, the executive director of the International Energy Agency, and the world’s foremost energy economist, said much more needed to be done but that the rapid uptake of solar power and electric vehicles were encouraging.

---

That's it for this week :)

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[theoutcastrogue]

"The majority of high-tech patent lawsuits are brought by patent trolls—companies that exist not to provide products or services, but primarily have a business using patents to threaten others’ work. Some politicians are proposing to make that bad situation worse. ...

The Patent Eligibility Restoration Act, S. 2140, (PERA), sponsored by Senators Thom Tillis (R-NC) and Chris Coons (D-DE) would be a huge gift to patent trolls, a few tech firms that aggressively license patents, and patent lawyers. For everyone else, it will be a huge loss. That’s why we’re opposing it, and asking our supporters to speak out as well. 

Patent trolling is still a huge, multi-billion dollar problem that’s especially painful for small businesses and everyday internet users. But, in the last decade, we’ve made modest progress placing limits on patent trolling. The Supreme Court’s 2014 decision in Alice v. CLS Bank barred patents that were nothing more than abstract ideas with computer jargon added in. Using the Alice test, federal courts have kicked out a rogue’s gallery of hundreds of the worst patents. 

Under Alice’s clear rules, courts threw out ridiculous patents on “matchmaking”, online picture menus, scavenger hunts, and online photo contests. The nation’s top patent court, the Federal Circuit, actually approved a patent on watching an ad online twice before the Alice rules finally made it clear that patents like that cannot be allowed. The patents on “bingo on a computer?” Gone under Alice. Patents on loyalty programs (on a computer)? Gone. Patents on upselling (with a computer)? All gone. ...

PERA’s attempt to roll back progress goes beyond computer technology. For almost 30 years, some biotech and pharmaceutical companies actually applied for, and were granted, patents on naturally occuring human genes. As a consequence, companies were able to monopolize diagnostic tests that relied on naturally occurring genes in order to help predict diseases such as breast cancer, making such testing far more expensive. The ACLU teamed up with doctors to confront this horrific practice, and sued. That lawsuit led to a historic victory in 2013 when the Supreme Court disallowed patents on human genes found in nature. 

If PERA passes, it will explicitly overturn that ruling, allowing human genes to be patented once again. ...

“To See Your Own Blood, Your Own Genes”

From the 1980s until the 2013 Myriad decision, the U.S. Patent and Trademark Office granted patents on human genomic sequences. If researchers “isolated” the gene—a necessary part of analysis—they would then get a patent that described isolating, or purified, as a human process, and insist they weren’t getting a patent on the natural world itself.

But this concept of patenting an “isolated” gene was simply a word game, and a distinction without a difference. With the genetic patent in hand, the patent-holder could demand royalty payments from any kind of test or treatment involving that gene. And that’s exactly what Myriad Genetic did when they patented the BRCA1 and BRCA2 gene sequences, which are important indicators for the prevalence of breast or ovarian cancer. 

Myriad’s patents significantly increased the cost of those tests to U.S. patients. The company even sent some doctors cease and desist letters, saying the doctors could not perform simple tests on their own patients—even looking at the gene sequences without Myriad’s permission would constitute patent infringement. 

This behavior caused pathologists, scientists, and patients to band together with ACLU lawyers and challenge Myriad’s patents. They litigated all the way to the Supreme Court, and won. “A naturally occurring DNA segment is a product of nature and not patent eligible merely because it has been isolated,” the Supreme Court stated in Association for Molecular Pathology v. Myriad Genetics. 

A practice like granting and enforcing patents on human genes should truly be left in the dustbin of history. It’s shocking that pro-patent lobbyists have convinced these Senators to introduce legislation seeking to reinstate such patents. Last month, the President of the College of American Pathologists published an op-ed reminding lawmakers and the public about the danger of patenting the human genome, calling gene patents “dangerous to the public welfare.”  

As Lisbeth Ceriani, a breast cancer survivor and a plaintiff in the Myriad case said, “It’s a basic human right to see your own blood, your own genes.” "

[ltash]

The Bodyguard pt-1

Part 2 & 3 link in the end.

SimonGhostRileyxfemalereader

The boardroom was sleek, modern, and imposing, with dark wood panelling and a sprawling glass table. Sunlight filtered through the floor-to-ceiling windows, casting sharp shadows across the faces of the people who had slowly filed in, each flashing rehearsed smiles in your direction. You leaned back in your chair, absentmindedly chewing on the end of a sleek silver pen, your eyes sharp, taking in every movement, every fake expression.

Five guards stood silently behind you, their presence a subtle but unmistakable reminder of your authority. You were untouchable here, or at least, that's what you needed them to believe. As the CEO and heiress of Aventis Pharmaceuticals, a company built on generational influence, you knew there were black sheep lurking within your empire. You could feel it in the way certain board members avoided your gaze, shifting uncomfortably under your silent scrutiny.

"Let's get started," you said, your voice calm but unyielding as you set the pen down, giving each person a measured look. "I need the details on the latest antinarcotic project we're working on."

There was a pause before the head of R&D, Dr. Marcus Lewin cleared his throat. He looked pale, though you couldn't tell if it was the lighting or nerves. "Ah... of course, Miss Aventis," he began, shuffling some papers before him. "We're in the third phase of clinical trials now. The formula has shown promising results, minimal side effects, with a faster recovery rate compared to the last version."

You raised an eyebrow, watching him squirm slightly. "Minimal side effects?" you repeated. "We're aiming for a groundbreaking product, Dr. Lewin. I expect 'minimal' to be an understatement."

"Yes, of course," he stammered, nodding vigorously. "I, uh, apologize. We're working on further improvements. There's also some data regarding efficacy rates in the latest testing group. I can forward the specifics to you."

You leaned forward slightly, your gaze hardening. "Forward them to me? Dr. Lewin, I'd prefer a comprehensive update now from you. Or are there... issues you'd rather not discuss here?"

A few other board members shifted uncomfortably, casting sidelong glances at one another. But Dr. Lewin managed a stiff smile. "No issues, Miss Aventis. We've been gathering the results carefully. We're confident we can meet the expected deadline and provide a full report for you to review."

You nodded slowly, letting the silence stretch. "Good. I expect nothing less. And, just to be clear," you said, glancing around the table at the assembled members, "I don't tolerate surprises. If there are any... discrepancies, now is the time to disclose them. Otherwise, I expect total transparency."

A hush fell over the room.

Your gaze shifted to Martin Hayes, the company's CFO, a man known for his sharp financial acumen and, at times, slippery ethics. He sat across the table, his fingers tapping nervously against his folder. He offered a tight, polite smile as he looked up to meet your eyes.

"And about our deal with that company?" you asked, your voice cool, with just a hint of impatience.

Martin cleared his throat, adjusting his tie. "Yes, of course, Miss Aventis. The partnership with Arcadia Biotech is progressing as planned. We've secured favourable terms for both manufacturing and distribution, ensuring a significant reduction in costs while increasing production capabilities."

You tilted your head, studying him. "And Arcadia is still unaware of our... competitive projects?"

He hesitated, just for a fraction of a second, but you didn't miss it. "They're completely in the dark," he assured quickly. "We've kept all sensitive projects under strict confidentiality clauses. As far as Arcadia is concerned, they're our exclusive partners in the development and distribution of the existing narcotic treatments."

You tapped your fingers against the table. "Good. I'd like a written assurance from you that our proprietary research won't leak. If Arcadia or any other competitor even hints at knowing about our new product, I'll know who to turn to, won't I, Martin?"

The colour drained slightly from his face. "Absolutely, Miss Aventis. You have my word; I'll have our legal team draft an ironclad document."

"See that you do." You leaned back, giving him a faint smile as if to relieve the tension just slightly. "And remember, gentlemen and ladies," you added, letting your gaze roam around the table, "we're here to lead the industry-not to compete in petty games. I expect only the highest standards of loyalty and discretion."

A murmur of agreement filled the room, the board members nodding.

You leaned forward, placing both hands on the table, and fixed each board member with a piercing stare. The boardroom fell silent, the tension thick in the air.

"Also, remember this," you said, your voice low but unwavering. "I am more than capable of running my father's company. Each of you is here because you're shareholders, yes, but let's not mistake that for immunity."

A flicker of uncertainty crossed a few faces, and you didn't miss a beat.

"If I find out that anyone here has tampered with our formulas, compromised our products, or made any attempt to sabotage the reputation of Aventis Pharma..." You let the threat hang in the air for a moment, letting them feel the weight of your words. "Then you'll all be sinking with me. I won't hesitate to bring down every last one of you along with this company if it comes to that."

Martin Hayes shifted uncomfortably, his collar suddenly seeming a little too tight. Dr. Lewin was looking down at his notes, his jaw clenched, while a few others exchanged uneasy glances.

"Now," you continued, sitting back but keeping your gaze sharp, "let's ensure that it never comes to that. We are all on the same side, or we should be. Our success is your success. I expect complete loyalty to the vision my father built and entrusted me to lead."

You let the silence settle, watching them absorb your message. Finally, you smiled, but it was a smile of steel. "Any questions?"

No one spoke up, and you nodded in satisfaction. The boardroom felt smaller, suddenly less crowded with ambition and more attuned to your authority.

The boardroom cleared, and with a curt nod, you dismissed the meeting. Rising from your seat, you walked out with purposeful strides, your five bodyguards falling in line behind you, each scanning the area, their presence, an unspoken wall of security. You exited the building and moved toward the parking lot, where the air was still and quiet, almost eerily so.

Your eyes drifted to a Hummer parked discreetly in the far corner. It felt out of place, like a shadow that didn't belong. You slipped into your sleek sports car, the engine purring to life, but an uneasy feeling gnawed at you. Suddenly, figures emerged from the darkness, men with sharp eyes and cold expressions, each one wielding M14 rifles. Diego Garcia's assassins. The Hummer door stayed shut, but you caught a glimpse of Garcia himself watching from within, his gaze locked on you.

Before you could react, a hail of bullets erupted. Your heart thundered as your bodyguards sprang into action, returning fire, but the assassins moved with ruthless precision. In moments, one by one, your guards went down, each man fighting until his last breath but hopelessly outnumbered. You watched in horror, paralyzed as they fell, each life extinguished in seconds. You barely registered your own scream, choked by terror and fury, as the sounds of gunfire faded, leaving only silence and blood.

Your hands fumbled, trying to unlock the doors, but they were stuck, trapping you in the vehicle like a helpless bystander in a nightmare. You felt your pulse race as the shadows closed in, and then Diego was there, standing right outside your window, his face illuminated in the dim parking lot light. He smiled, a dark, twisted smile that sent chills through you.

"Mine," he whispered through the glass, his voice laced with malice and satisfaction.

A wave of dizziness overtook you, and everything spun. His words echoed in your mind as your vision blurred. Helpless and horrified, you slipped into unconsciousness, the last image seared into your memory: Diego's face, and that sinister smile that promised nothing but darkness.

A week had passed since the attack, but the memory of it still haunted you, flickering at the edge of your thoughts as you sat on the plush velvet sofa in your expansive drawing room. Sunlight poured through the towering windows, casting a warm glow over the gleaming marble floors and the breathtaking view of the Los Angeles skyline stretched beyond, grounding you in the opulence of your mansion. The faint hum of a helicopter faded as it settled on the rooftop, carrying with it your new bodyguard: Lieutenant Simon "Ghost" Riley, a man whose reputation preceded him.

The sound of heavy boots echoed through the hallways, each step precise and deliberate, growing closer until the double doors swung open. You rose from the sofa, instinctively straightening your posture as the figure of Ghost entered the room, his presence consuming it instantly. He was massive, towering over you at 6'4", his muscular frame stretching the fabric of his black t-shirt, every inch of him exuding strength and danger. His broad chest and shoulders were carved with the kind of power that comes only from a life on the battlefield, and his thick, muscular thighs tested the seams of his black cargo pants. A holstered firearm rested against his leg, a stark reminder of the deadly world you were stepping into.

But it was his eyes that struck you the hardest. Deep brown and unwavering, they locked onto yours with an intensity that felt almost physical, as if they could see straight through every secret you held. A skull-patterned bandana covered most of his face, concealing his expression, but his gaze was enough, it was fierce, calculating, and unyielding. His buzz-cut hair, a dirty blonde, caught a hint of sunlight, and a jagged scar traced down his left temple, the brutal souvenir of battles fought and survived.

The contrast between the two of you felt almost surreal, his raw, masculine power against your delicate, fragile beauty. At just five feet tall, your frame seemed almost dainty by comparison, a striking contrast of elegance and strength. The soft material of your dress hugged your figure, emphasizing the curve of your waist and your petite, curvy form, while your brown, doe-like eyes met his with a mixture of curiosity and caution.

"This is Ghost, ma'am," he nodded, his voice low, gravelly, resonant. The sound of it sent a shiver down your spine, filling the room as thoroughly as his presence did.

You hesitated, caught off guard by his intensity, before extending your hand. "Lieutenant Riley," you greeted, your voice steady even as you took in every detail of the man before you. "I've heard a lot about you."

He accepted your hand, his grip firm and respectful, but his eyes stayed sharp and assessing, as if already calculating every risk, every angle of protection.

"Welcome to my mansion. How was your journey?" you asked, settling yourself elegantly on the velvet couch, your posture flawless.

"The journey was fine, ma'am," he replied, his deep voice rumbling through the room. He took a step closer, crossing his arms, his gaze intense and assessing. "The view from the landing pad is quite something, too."

You felt his eyes linger, moving over you, taking in the details of your petite frame and the way your bodycon dress clung to your curves. He tried to keep his focus professional, but it was hard not to notice the finer details.

"Tea, coffee, or whiskey?" you offered.

A faint smirk tugged at the corner of his mouth. "Whiskey," he replied without hesitation, his gaze still fixed on you.

With a small nod, you rose from the sofa and moved to the bar across the room, reaching for the bottle of Kentucky bourbon. His eyes tracked your every movement, lingering on the bare skin between the thin straps of your dress. The dress hugged your form perfectly, and though he kept his face stoic, his attention remained unwavering as you poured the amber liquid into a glass.

You turned, holding the glass in your hand, and extended it to him. He stepped forward, his calloused fingers wrapping around the glass, brushing lightly against yours. The brief contact sent a jolt up your arm, but his face revealed nothing, not a hint of reaction. He lifted the glass to his lips, taking a slow, measured sip, all the while keeping his gaze steady on you.

You leaned back onto the plush sofa, crossing your legs elegantly, watching as he brought the glass of bourbon to his lips, taking a slow sip without breaking eye contact. The slight tension in the room was palpable, each of you sizing up the other, feeling out the boundaries of this unfamiliar relationship.

"So," you murmured, a faint hint of curiosity in your tone, "you wear the skull mask, Ghost..."

His eyes narrowed slightly above the edge of his mask, a flicker of irritation passing through them. He lowered the glass, studying you in silence for a moment before he replied, his tone even. "It's part of the job," he said. "Helps me keep things... impersonal. No one gets to see my face."

You tilted your head, not breaking his gaze. "Not even me?" you asked softly, a subtle challenge in your voice. "Not even the person you're here to protect?"

There was a beat of silence, his eyes dark and unreadable behind the mask. For a moment, you thought he might look away or ignore the question altogether. But then he spoke, his tone a shade more guarded. "Protection is about distance, ma'am. Masks help with that. It's not personal, just how I keep a clear line between my duty and... everything else."

You took a slow breath, absorbing his words. "Clear lines, huh?" You leaned forward, resting your chin on your hand as you studied him, his formidable frame, his stoic face, the shadows that clung to him. "Is that what works best for you, Lieutenant? No attachments, no faces, just the mission?"

He held your gaze, unflinching. "It's what's kept me alive." His answer was calm, unwavering, as though he'd thought it through many times before.

You nodded, acknowledging the harsh reality he lived by. "Well, I suppose I can respect that," you replied, your voice soft but thoughtful. "But you should know, Ghost, this won't be a typical mission. There are things at play here that... don't fit within clear lines."

He didn't respond, but his intense gaze on you seemed to deepen, like he was silently bracing himself for the unknown. Finally, he gave a slight nod, the barest hint of understanding in his eyes.

"Understood," he said, his tone low and resolute. And in that moment, you realized that, for all the distance he wanted to maintain, his presence, steady and unyielding, was exactly what you needed.

"Diego Garcia," you said, your voice quiet but resolute. "The Santiago Cartel."

Ghost's expression darkened. The name carried weight, a reputation steeped in violence. "Diego Garcia," he repeated, his tone grim. "Powerful, ruthless, no ordinary drug lord."

"He's bigger than Valeria Garza. More dangerous than El Sin Nombre."

Ghost's gaze was sharp, intense. "I know. Santiago Cartel is one of the deadliest in Mexico, and Garcia's the head of the snake."

"He's after me," you admitted, feeling the weight of the words as they left your lips.

Ghost's eyes narrowed. "Why?"

"My company produces anti-narcotics," you explained. "We sell the cure. He sells the poison."

Recognition flickered in his eyes. "You're cutting into his profits," he said, understanding dawning. "You make him look weak."

"We're about to launch a new antidote," you continued. "One that blocks the effects of drugs like cocaine, fentanyl. It's still in testing, but it'll be on the market soon."

He nodded slowly, processing it. "The cartel won't let that happen. They'll do whatever it takes to stop you."

You felt a shiver at his words but pushed on. "He's already killed for it. My bodyguards... I watched them die, right in front of me."

A muscle tightened in Ghost's jaw. "He killed them in front of you," he said, his voice low, edged with anger. "Bastard doesn't play by any rules."

"He sent his men. They were armed with M14 rifles. My men didn't stand a chance."

His expression grew grim. "M14s. No wonder your guards didn't make it."

"Laswell suggested you," you continued, watching him closely. "She said if anyone could handle Garcia, it'd be you."

He met your gaze, a flicker of confidence in his eyes. "She's not wrong. I've dealt with men like him before." His voice was calm, unshaken. "And I'll take him down.

"Let me show you around," you said, motioning for him to follow.

Ghost nodded. "Lead the way."

The mansion was sleek and modern, blending luxury with privacy. As you walked through the marble driveway, you passed the tall, solid wooden door into the living room, its polished granite floors gleaming in the light. To the left, a door opened to the swimming pool area, surrounded by greenery. Above, a glass skywalk connected the house, offering a view of the water below.

A spiral staircase led to the second floor where your master bedroom and its luxurious bathroom were located, complete with a Jacuzzi and a high-tech shower. The back lawn opened up to the underground parking area.

As you walked, Ghost took in everything with a sharp, calculating gaze. The mansion wasn't just a home, it was a fortress. Every detail, from the barbed wire to the strategic location, was a reminder of the protection it offered.

"Like what you see?" you asked, watching his reaction.

Ghost's expression was unreadable, but his voice was steady. "It's secure," he said, eyes flicking over the property. "More than most would need."

"It's still smaller than other mansions here," you countered.

"Smaller, yes. But more secure," he said. "Most billionaires settle for an alarm system. You went further."

"The reason I don't go bigger is security," you replied. "I know Diego could breach it, but it's L.A. He'd think twice."

Ghost nodded. "Smart. L.A.'s dangerous, but Garcia would hesitate."

"Good. Let him be intimidated. Makes my job easier."

He shifted his attention back to you. "What about inside? Armed guards?"

"Outside," you said. "The perimeter's covered."

He raised an eyebrow. "Inside?"

"You..." you trailed off, letting him fill in the rest.

Part 2

Part 3

Pic credit: VhenanVirabelasan

https://www.instagram.com/vhenan_virabelasan?igsh=MWpmdnVzaXN5czYyZg==

[heartlaboratory]

Part of an influencer job is to present and test products live streaming. For a random series of event the logistical office of a pharmaceutical company, which asked her to test some products, sent her an experimental compound to make flesh invisible for research purposes instead of a moisturizing cream for the body. She realized something was wrong by looking at the comments of the live stream... "Oh my God, what's this massive thing pulsing on my chest??" she screamed terrified. "That's your heart!! And it looks really unhealthy!!" "Smoke, alchool and total lack of physical training were pretty effective on you" "guys, we're probably looking at her last beats" some people answered... and sadly they were pretty right...

[itclabs]

Discover why partnering with a pharmaceutical testing lab is crucial for safeguarding patient health. Our latest blog explores the essential role of testing labs in ensuring drug safety, efficacy, and regulatory compliance. Learn how ITC Labs' expertise and advanced facilities can support your drug development process, from initial testing to market release. Read more to see how we can help you meet the highest standards in pharmaceutical testing and ensure your medications are safe and effective.

[reality-detective]

Brigham Buhler on the Dark History of the Medical Industrial Complex

"There was a small little company that reached out to the Third Reich and said, 'Hey, we need 150 participants for our clinical trial.' The nazi regime shipped 150 healthy jewish women to this pharmaceutical company to test its products. Literally, within six months, there's letters back to the Third Reich from this pharmaceutical company saying, 'Thank you so much for your cooperation. The women arrived in great health and working order. Unfortunately, none of them made it through the initial phases of our trial.' They killed 150 women. 'We kindly request that you send us another 150 women.' That little company became Bayer which is now a mega pharmaceutical company." 🤔

[bats-and-birds-24]

Chapter 3:

Two weeks had passed since the incident with the Joker Gang, and Tim was still not allowed to leave the manor.

He protested to Bruce, but he was firm in not letting him back into the field until he had fully healed.

Seeing Tim's frustration, Alfred explained that Bruce was only doing this for his own wellbeing.

Tim doubted that, but a part of him wondered if Bruce was genuinely just concerned for his safety.

There were times where Tim had caught Bruce staring at him with a mixture of worry and relief on his face.

The cynical side of him quickly dashed that hope as he realized that Bruce probably just didn't want to ruin Batman's reputation by losing another Robin.

Tim knew the importance of reputation, his parents had made that very clear to him.

His mind drifted back to when he was six years old. He remembered saying something a bit too bluntly to an important looking man in a business suit.

He'd forgotten what he said, but he remembered the punishment he got because of it.

He was isolated in his room for three days, with meals being sent up to him via staff, who were ordered not to talk to him.

He remembered that his parents' reasoning was that he should learn that there will be consequences for ruining their relationship with an important benefactor of their archaeological digs.

Tim felt a pang of anger at the memory. At least they were on a dig in Peru at the moment, he doesn't have to worry about dealing with them for now.

Alfred noticed him stiffening and suggested that he take a walk around the Wayne estate to clear his mind.

Tim just nodded and went up to get his camera. He might as well do something productive.

A few hours of blissfully ignoring his problems did wonders for his mood, until he was rudely brought back down to earth as he came across Jason's grave.

He had loved Jason. Even if they had never met, Jason had left a huge impact on Tim's life.

Tim may have figured out Dick's identity as Robin at the tender age of three, but he didn't actually join Batman and Robin in their nightly jaunts until he was nine.

By that time, Jason had already established himself as the next Robin.

Jason was his Robin.

His heart shattered when he realized that Jason had died.

He didn't want to disrespect Jason's passing, but someone had to rein Batman in.

Tim paused his train of thought and stepped closer to the grave. Something felt off, the dirt on the grave felt too fresh. To the untrained eye, it seemed normal, but Tim's detective senses were roused.

Has someone disturbed it? That couldn't have been possible. Bruce kept a close eye on the estate to ensure no one breaks in.

Tim took a few steps back, and snapped a picture of the grave. His emotions took a back seat as the gears in his mind began to turn.

If anyone had somehow managed to disturb Jason's grave, they must have been very skilled, which leaves out any petty grave robbers.

Tim ran back to the manor to retrieve a DNA analysis kit. He only met Alfred in the hallways who's only remark was to slow down, lest he hurt himself.

All Tim needed was confirmation that nothing had happened to Jason's grave, that's all.

"Sorry about this Jay." Tim muttered under his breath as he quickly chipped off a few pieces of the gravestone. He could use them to run a DNA test when he was back at the batcave.

Tim hurried back into the manor to run his tests.

The DNA analysis came back as positive for Talia Al Ghul.

Tim stared at the bat computer screen blankly.

'Talia Al Ghul'

Tim took a moment to process that fact.

Maybe Talia was just visiting, Bruce had mentioned that Jason and Talia has met before.

He didn't have time to mull over that thought, as the soil analysis came back. The determining factor on whether this was just a visit, or something more.

The soil in the grave had a markedly different chemical composition when compared to what was usually found in Gotham.

For one, it lacked the pollutants from Gotham's chemical and pharmaceutical companies. The analysis also revealed that there were trace amounts of a chemical that matched the league of assassin's Lazarus pits'.

This clinched it. The league was after Jason, or more accurately, Jason's body. Tim thought of the reasons behind that move, they must have known that it would eventually be found out by Bruce. They must know that Batman is a dangerous enemy to have.

Suddenly, a spark of hope bubbled up in him.

What if they wanted to revive Jason using the Lazarus Pits?

Tim tried to shake the thought from his brain. It was much more likely that the LOA just wanted an unlimited source of Jason's DNA.

But by now, the spark had nestled deep in his heart. If there was even a chance that Jason was alive, then he had to investigate.

The question now was whether or not he should involve Bruce in the mission.

Bruce was and still is, in a terrible place. Jason's death had destroyed Bruce's soul so thoroughly that he avoided visiting Jason's grave after the funeral.

Tim taking on the Robin mantle relieved some of his burdens, but he was still by no means stable.

He didn't know how Bruce would react if he found out about the grave robbing.

He came to a decision.

Under no circumstances should Bruce know of this mission. He'll figure out how to break the news to him after the mission is complete. But as of now, Bruce was too much of a liability.

Tim's mind began to formulate a plan to retrieve Jason from the league.

If Talia was involved, then it was likely that Jason will be found high up in the league hierarchy. This removed most common league training grounds and only left the highly defended sacred city of 'Eth Alth'eban, and the main base of Nanda Parbat.

There was also the league of shadows, which contrary to popular belief, was not actually a splinter faction of the league of assassins, and instead acted as a specialized arm. Acting as though the two were separate entities was a tactic by Talia to throw off anyone trying to bring the league down.

Tim mulled over his options.

The league of shadows had a base at Sullivan island in the South of Gotham, which would be his easiest point of entry.

However, he's 90% sure that the base is there exclusively to keep an eye on Batman and his associates. Tim was certain that he would be captured if he ever so much as set foot on the island.

Unless, that was what he wanted.

He could get caught voluntarily. He knew from working on cases related to the League of Assassins with Bruce that Ra's Al Ghul' had taken a special interest in the Bat and would likely be thrilled if the little birdie waltzed right into his cage.

Tim was 90% sure that he won't die from attempting this, but even if he did die, Ra's is likely to just dunk him in the Lazarus Pits, so he should be fine.

Now all he needed to do was throw Batman off his scent.

He could tell Bruce that he was going back to Drake manor for a month to work through some Drake industries work. Bruce wouldn't question it too much and Alfred would just be happy that he's taking a break from being a vigilante.

If everything works out according to plan, Bruce would never even notice that he was missing.

He hacked into the cameras at Drake manor to make it seem as though Tim was just doing Tim things. This way, if Bruce bothered to check the cameras, he wouldn't come across anything incriminating.

Tim packed some crucial gear and prepared to get kidnapped. If it all goes smoothly, he should be sent directly to Talia's doorstep.

He got on Redbird and began his journey south.

[darkmaga-returns]

WHAT RULES ARE THESE THEN?

In the EU, they are known as Rules and Guidance for Pharmaceutical Manufacturers and Distributors 2017 (The Orange Guide). The equivalent in the US is the Code of Federal Regulations, Title 21, otherwise referred to as 21 CFR.

They have been in place for decades, and have become increasingly stringent as incidents have occurred in the supply chain to threaten the safety of patients. In 2007, one such incident occurred, resulting in death and serious adverse events, see below:

Inside Pharma

PHARMACEUTICAL SUPPLY CHAINS IN THE NEWS, FOR THE WRONG REASONS

THE HEPARIN TRAGEDY In 2007/8, pharmaceutical supply chains became the subject of global debate among key stakeholders, but for the wrong reasons. A tragic event occurred that shocked the world into realizing that pharmaceutical supply chains had the potential to kill and maim unsuspecting patients…

Read more

3 years ago · 2 likes · Hedley Rees

This tragic incident lead to legislation being passed on either side of the pond. In the EU, it was the Falsified Medicines Directive, 2011. In the US it was the Drug Supply Chain Security Act (DSCSA), 2013.

The aim of the legislation was to prevent such an incident ever happening again.

RULES IN THE ORANGE GUIDE WERE TIGHTENED TOO

In the EU, major changes were also made to the Orange Guide, Chapter 5: PRODUCTION.

This was to protect patients further, by placing obligations on companies manufacturing medicines to trace right back to the upstream sources of all materials used, to ensure they were genuine. The obligations also required traceability records to be kept, and audits carried out to ensure those companies were working to the regulations.

LEGISLATION DID NOT GO FAR ENOUGH

Unfortunately, as the legislation passed (for a number of reasons we can’t go into here) it only applied, and still does, to finished products as they travel from the finished product manufacturer to wholesalers and pharmacies.

Prevention of upstream adulteration, as per heparin, is dependent on manufacturers complying with the Orange Guide, Chapter 5 provisions.

TRUST ME, THEY COULD NEVER HAVE DONE THAT!

The thing to remember is that Good Manufacturing Practice (cGMP) applies to clinical trials, as well as commercial supply. It would have to, wouldn’t it, as the drugs are being tested on humans.

I would have more chance of climbing Everest naked (not a pretty sight!) than the manufacturers would have had in securing full traceability AND applying the cGMP rules for clinical trial supplies.

Something for medical freedom fighters to ponder, questions welcome :)

Hedley

[animal-care]

Exploring Trends Shaping the Animal Care Market

The Animal Care Market is undergoing significant transformations driven by evolving consumer preferences, technological advancements, and emerging trends. In this article, we delve into the latest trends shaping the landscape of the animal care industry and their implications for market players.

Humanization of Pets: Treating Pets like Family

One of the prominent trends in the animal care market is the increasing humanization of pets. Pet owners are treating their animals more like family members, seeking products and services that cater to their pets' health, comfort, and emotional well-being. This trend has led to a growing demand for premium pet food, grooming services, and accessories designed to enhance the quality of life for companion animals.

Natural and Organic Products: A Shift towards Healthier Options

Consumers are becoming more conscious about the ingredients and materials used in pet care products, leading to a surge in demand for natural and organic alternatives. Pet owners are seeking products free from artificial additives, preservatives, and chemicals, opting instead for wholesome and sustainable options that promote the health and vitality of their pets. This trend has propelled the growth of natural pet food, eco-friendly toys, and biodegradable pet accessories in the market.

Telemedicine and Remote Veterinary Care: Convenient Healthcare Solutions

Advancements in technology have revolutionized the way veterinary care is delivered, with the adoption of telemedicine and remote monitoring solutions gaining traction in the animal care industry. Pet owners are increasingly turning to virtual consultations, telehealth platforms, and mobile apps to seek medical advice, diagnosis, and treatment for their pets, especially amid the COVID-19 pandemic. This trend has expanded access to veterinary services, improved convenience for pet owners, and facilitated early detection and intervention for pet health issues.

Personalized Nutrition and Wellness: Tailoring Care for Individual Pets

Pet owners are embracing personalized approaches to pet nutrition and wellness, recognizing that each animal has unique dietary and health needs. The demand for customized pet food formulations, tailored supplementation, and genetic testing services is on the rise as pet owners seek to optimize their pets' health and longevity. This trend has spurred innovation in the development of personalized pet nutrition plans, DNA testing kits, and health monitoring tools that cater to individual pets' requirements.

Sustainable and Ethical Practices

Environmental sustainability and ethical sourcing have become key considerations for pet owners when choosing products and services for their animals. There is a growing emphasis on eco-friendly packaging, cruelty-free ingredients, and ethical manufacturing practices in the animal care market. Companies are increasingly adopting sustainable initiatives, such as carbon-neutral operations, recyclable packaging, and ethical sourcing of raw materials, to align with consumer values and reduce their environmental impact.

Conclusion

The animal care market is evolving rapidly, driven by shifting consumer preferences, technological innovations, and societal trends. By staying attuned to these emerging trends and embracing innovation, companies can capitalize on new opportunities, differentiate their offerings, and meet the evolving needs of pet owners and their beloved companions. As the bond between humans and animals continues to strengthen, the animal care industry is poised for continued growth and transformation in the years to come.