#osteoclasts

[bpod-bpod]

Monocyte, Microlith, Mineral?

Every breath can be a struggle if you have the rare lung disease pulmonary alveolar microlithiasis. It’s caused by a faulty protein in the membranes of cells that line alveoli, tiny air sacs that fill your lungs. This causes mineral structures called hydroxyapatite microliths to form inside alveoli. Researchers now investigate this process by analysing RNA – a marker for gene activity – in lung tissue from human patients and a mouse model of the disease. Looking at immune cells called monocytes, which can develop into bone-degrading cells called osteoclasts, the team found that osteoclast-related genes were activated in alveolar monocytes. They also found that microliths, pictured using scanning electron microscopy at different resolutions in human (top) and mouse (bottom) lung tissue, contained osteoclast enzymes. This suggests that in response to microliths forming, osteoclast-like cells kickstart into action. This may present a new research avenue for pulmonary alveolar microlithiasis therapies.

Written by Lux Fatimathas

Image adapted from work by Yasuaki Uehara and colleagues

Department of Internal Medicine, Division of Pulmonary, Critical Care, and Sleep Medicine, University of Cincinnati College of Medicine, Cincinnati, OH, USA

Image originally published with a Creative Commons Attribution 4.0 International (CC BY 4.0)

Published in Nature Communications, March 2023

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[biology-geology-beaches-india]

The Science Research Manuscripts of S. Sunkavally, page 327.

[medicomunicare]

About blasts, clasts and receptors: PT H in the bone cannot be erased, yet GPRC5 is not tALK-3 with other signals

Osteoporosis is a skeletal condition that leads to the weakening of bones, making them porous, fragile, and prone to breakage. A whopping 8.9 million fractures are caused by osteoporosis annually. The aging population is the most vulnerable to primary osteoporosis, given, their frailty, and often, requires long-term therapy and support. Advances in healthcare and the corresponding rise in the…

[foolishfoolsgold]

Ok this was just gonna be a cell type showcase but I think I’m keeping these guys as OCs lol. Not too sure how I feel abt the outfit, I tried to go with “liver colors” and got this. Might design some more in the future

I’m calling them JT-4845 (she/her for each head, they/them for the whole cell). The left one is a waitress and the right one is a freelance DJ for parties, so they’re always running around from place to place to go do stuff, showing up to gigs in the restaurant uniform, and just being annoying to each other. For example:

Left: “and would you like to try today’s special?”

Right: *pretending to mind control the customer* “oOOOOOoooOOO, you want to try the speciaaaaalllll!”

[Start ID: Colored and shaded digital drawing of a two-headed cell (hepatocyte) on a grey background. They have a brown membrane and bright salmon patterns. Each head has dark hair/flagella with blonde highlights, but the left head’s is straight and parted to the side, were the right head’s is in messy dreadlocks. Both heads have brown eyes, and the left one has earrings, eyebrow piercings and straight stripes, where the right one has no piercings, headphones around her neck, and more splotchy patterns. Their shared body is wearing a dark read suit with a floppy bow tie. The right hand is making a “rock on!” Gesture, and the left is holding a notepad. They have a single red tail with dorsal lobes along its length. Notes talk about how hepatocytes have a close relationship with immune cells, and how they can have either one or two nuclei/heads. Binucleated cells are psychologically and legally two different people, and also that the tail can secrete detoxifying chemicals. End ID.]

[thestorybotsfanlol]

Phagocytes

Osteoclast looks so cursed wtf😭

[aturinfortheworse]

Learning about hormones is funny because they're all named after what they do (like "growth hormone." guess what that fucker does) so it should be easy to remember them, except that most of them have such specific niche jobs that's actually no help at all. Oh yeah sure "lutenizing hormone" I totally know what that means and what it does. I fucking love to lutenize. Catch me out here lutenizing all day long with my buddy Lutenizing Hormone.

[a-simple-bacterium]

[humancelltournament]

Propaganda!

An osteoclast is a type of bone cell that breaks down bone tissue. This function is critical in the maintenance, repair, and remodeling of bones of the vertebral skeleton.

T cells are one of the important types of white blood cells of the immune system and play a central role in the adaptive immune response. Groups of specific, differentiated T cell subtypes have a variety of important functions in controlling and shaping the immune response.

[not-poignant]

My knee is shot to hell and I think the next step before surgery might be cortisone injections.

But on the journey to like...keeping my ability to walk (though I've lost the ability to hike and/or walk more than 10 minutes which blows, I'm hoping to get it back still), my physiotherapist, who is also a personal trainer, got me doing a whole bunch of upper body stuff, which I cringed at and was like 'nooooooo' and just 'I'm gonna be so bad at thissss'

But it ended with me actually really enjoying it and now I bench press (don't ask me how much, it's a pitiful amount, my arms are as strong as limp noodles and i'm not not interested in 'how much can you do i bet i'm better at it than you are' like yes you are yes you are now go away) and I look forward to my arm workouts the most out of anything I do.

My knee's still an absolute shitweasel though.

[niaorta]

Dialyo,osteoclast

I use to make him the exact opposite as to him now,basically I drew him like an introvert.He's literally a new person now lol

anyways he's 33 years old,226 cm and his blood type is O-

[jppres]

Effect of cocoa administration during orthodontic tooth movement on RUNX2, calcium levels, and osteoclast bone-resorbing activity in rats

J. Pharm. Pharmacogn. Res., vol. 10, no. 5, pp. 857-864, September-October 2022. DOI: https://doi.org/10.56499/jppres22.1434_10.5.857 Ananto Ali Alhasyimi*, Pinandi Sri Pudyani Department of Orthodontics, Faculty of Dentistry, Universitas Gadjah Mada, Indonesia. *E-mail: anantoali@ugm.ac.id Abstract Context: Cocoa contains caffeine-rich methylxanthine, which promotes accelerated orthodontic…

[mindblowingscience]

Bone is maintained via a delicate balance between formation and resorption, and its imbalance leads to bone related diseases like osteoporosis, rheumatism and periodontitis. Researchers led by Osaka University have revealed that proteins named Rab32 and Rab38 play pivotal roles in bone resorption in osteoclasts. These proteins are also crucial for pigmentation of hair and skin. The researchers have published two articles, "Characterization of Rab32- and Rab38-positive lysosome-related organelles in osteoclasts and macrophages" in the Journal of Biological Chemistry and "Rab32 and Rab38 maintain bone homeostasis by regulating intracellular traffic in osteoclasts" in Cell Structure and Function.

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[solomonara]

Game: 10 first lines challenge

Thanks for the tag @stevieraebarnes! Let's see if my first lines can hold a candle to your absolute bangers.

Rules: Share the first line of your last ten published works or as many as you are able to and see if there are any patterns!

1. Investigator: The crash of shattering glass, and a lot of it, startled the pleasant hum of socialite conversation into hiding.

2. For Good: Some days, Link wonders how they got so lucky.

3. Here, After: If asked, Sidon would not be able to say truly when it began.

4. The Cross Purposes Job: "Well, Mr. Jeffries," Sophie – or rather, Ludmila Popova, official representative of a wealthy overseas tech consortium that was definitely not a thinly veiled front for any shady Eastern European government, no matter how much they were funded like one, wink nudge – said with a charming smile.

5. Scarf: "Emma. What is that?" Georgia asked, stopping immediately inside the door to their apartment.

6. Fever Reducer: Bruce stared at the nearly empty shelf in the breakfast aisle, despairing.

7. Osteoclast: Dick knew, even before he was fully awake, that he wasn't going to enjoy what he discovered when he opened his eyes.

8. Per Aspera: Jason Todd was bleeding.

9. Looked After: Make sure he's looked after.

10. The Damned Prince's Bodyguard: The Damned Prince of Gotham surveyed his domain with a great deal of satisfaction and a very small amount of champagne.

Well, I don't know. Most of these introduce the main characters (but not Looked After or Investigator). Most of these ask a question or imply one (but not For Good or, again, Looked After.) And what was I thinking with The Cross Purposes Job. That's so many words... Maybe I should be looking at second lines XD

Hey @elwon, @dragonsorceress22, @bitterleafs, @burntheupholstery, @unicorncoalition you want to give it a whirl?

This invitation is also open to anyone who is reading it. Yes you! And tag me when you do it, I want to read your first lines (even you, stranger.)

[heavenslittlemachine]

i would love to be an osteoclast i think i would be really really good at secreting corrosive fluids for a single demo job and then killing myself

[thestorybotsfanlol]

Bone Cells

I will try to draw the other types of cells without having an artblock