#osteoblasts

[bpod-bpod]

Cell Block

Cells are often on the move, but how they navigate obstacles is a little mysterious. Here researchers create a sort of assault course for young pre-osteoblasts – cells destined to develop into bone. A microscope zooms down from above capturing the scene after eight days of challenging growth around a hemispherical bump (cells seem to prefer valleys to mountains). But these cells, highlighted in red with DNA in blue, are adapting. They align their stress fibres – stretchy bundles of actin used to change their shape and direction. Researchers believe cells align some of their stress fibres in the direction of movement while others brace across the cell to limit bending. Cells working together means the tissue can reach out between these obstacles, like climbers strung together navigating a mountain pass (although a million times smaller). Such insights may suggest ways to support migrating cells during development, or tissues remodelling after injury.

Written by John Ankers

Video from work by Sebastien J. P. Callens and colleagues

Department of Biomechanical Engineering, Delft University of Technology (TU Delft), Delft, The Netherlands

Video originally published with a Creative Commons Attribution 4.0 International (CC BY 4.0)

Published in Nature Communications, March 2023

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[medicomunicare]

About blasts, clasts and receptors: PT H in the bone cannot be erased, yet GPRC5 is not tALK-3 with other signals

Osteoporosis is a skeletal condition that leads to the weakening of bones, making them porous, fragile, and prone to breakage. A whopping 8.9 million fractures are caused by osteoporosis annually. The aging population is the most vulnerable to primary osteoporosis, given, their frailty, and often, requires long-term therapy and support. Advances in healthcare and the corresponding rise in the…

[ziriamcaps]

been playing this indie rpg called Osteoblasts you're a skeleton recently resurrected by a Cat Witch and the first dungeon and score of enemies u fight are demon dogs lmao

[thestorybotsfanlol]

Bone Cells

I will try to draw the other types of cells without having an artblock

[aturinfortheworse]

Learning about hormones is funny because they're all named after what they do (like "growth hormone." guess what that fucker does) so it should be easy to remember them, except that most of them have such specific niche jobs that's actually no help at all. Oh yeah sure "lutenizing hormone" I totally know what that means and what it does. I fucking love to lutenize. Catch me out here lutenizing all day long with my buddy Lutenizing Hormone.

[sandwichedbread]

[a-simple-bacterium]

So like, everything in the body is made out of basically the same stuff right? So when something breaks and gets destroyed, who clears the rubble? Where does it go? Does a phagocyte eat it? Do you sometimes take a walk and Ms Macrophage is trying to gnaw on conk crete? Has a neutrophil eaten a door? So many questions

[staceymatch]

Osteoblast

[harmandip]

" 5 Crucial Roles Vitamin D(Sunshine Vitamin) Plays in Maintaining Strong Bones"

Vitamin D, often referred to as the “sunshine vitamin,” is a crucial nutrient that plays a pivotal role in maintaining optimal bone health. Beyond its association with sunlight, this vitamin is essential for various bodily functions. Let’s delve into the five significant reasons why vitamin D is indispensable for the strength and well-being of our bones. Calcium Absorption: Vitamin D facilitates…

[valdevia]

Postmortem cross-section of a femur affected with bone pearls, also known as osteoperlomas.

While initially harmless, these shimmering benign tumors can lead to major fractures. Despite this, bone pearls have been prized throughout history, leading some to induce their formation for later harvesting.

Bone pearls are usually induced by injecting small calcium carbonate impurities into the bloodstream. They become embedded in the bone tissue and cause abnormal osteoblast growth, leading to osteoperlomas.

Surgical induction may also be performed to obtain pearls of the desired shapes.

[staryarn]

THE POWER STROKE???

Hm

[bpod-bpod]

Fractured Relationships

Break a bone and a frenzy of activity ensues to repair it. Bone-forming cells (osteoblasts) and their precursors (osteoprogenitors) take charge. However, fractures don’t always heal well. Consequently, growth factors are sometimes given to promote healing, specifically BMP which promotes bone formation and PDGF-BB which maintains osteoprogenitor numbers. Researchers investigate how they work in a mouse bone fracture model. MicroCT of fractured bones (pictured) revealed that adding high dose BMP, low dose BMP or PDGF-BB (top, left to right) promoted bone regeneration compared with no treatment (bottom left) or combining different BMP doses with PDGF-BB (bottom middle and right). Analysing the cell types revealed that BMP2 alone increased osteoblast and osteoprogenitor numbers but failed to do so when combined with PDGF-BB. While separately BMP2 and PDGF-BB promote bone healing, together they have the opposite effect. Further unpicking their interactions may help advance bone healing treatments.

Written by Lux Fatimathas

Image adapted from work by Sanja Novak and colleagues

Center for Regenerative Medicine and Skeletal Development, UConn Health, Farmington, CT, USA

Image originally published with a Creative Commons Attribution 4.0 International (CC BY 4.0)

Published in npj Regenerative Medicine, January 2023

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[regexkind]

I go in for an X-ray and an anomaly is revealed. Zooming in, they see that the osteoblasts seem to be oriented fairly regularly, in either a vertical or horizontal orientation once a particular frame of reference is chosen. When assembled linearly, a binary sequence forms that is a triprime in length; the three primes represent the width, height, and frame count of a video encoded in the osteoblasts; half of the video is furry pornography, and the other half appears to be visual noise. The visual noise is then revealed to actually encode base pairs for a protein, and the protein is actually a contagious prion disease that turns anyone who becomes infected into a pervert

[humancelltournament]

Propaganda!

Adipocytes, also known as lipocytes and fat cells, are the cells that primarily compose adipose tissue, specialized in storing energy as fat. Adipocytes are derived from mesenchymal stem cells which give rise to adipocytes through adipogenesis. In cell culture, adipocyte progenitors can also form osteoblasts, myocytes and other cell types. There are two types of adipose tissue, white adipose tissue (WAT) and brown adipose tissue (BAT), which are also known as white and brown fat, respectively, and comprise two types of fat cells.

The X chromosome is one of the two sex chromosomes in many organisms, including mammals, and is found in both males and females. It is a part of the XY sex-determination system and XO sex-determination system. The X chromosome was named for its unique properties by early researchers, which resulted in the naming of its counterpart Y chromosome, for the next letter in the alphabet, following its subsequent discovery.

[ravings-of-a-mad-scientist]

Boneseekers Comic

(The body sometimes confuses Lead and Strontium-90 for calcium, so this Osteoblast [the cell type that makes bones] takes them and puts them inside the bones.)

Lead doesn't just stick around poisoning your brain, some will get put in your bones and eventually will fall out of your bones years or decades later, then poison your brain.

Strontium-90 is a radioisotope found in nuclear bomb fallout, a ton of it got put into the atmosphere back when testing nuclear bombs was still a thing, so everyone who so much as breathed back then still has some little Strontiumballs in them, continuously irradiating their bones. Fun!

Y’know, with that and all the lead and mercury sitting around inside people’s skeletons and brains thanks to leaded gasoline, paint chips, and tooth fillings, old people sure do have a lot of heavy metals inside them. I wonder if you could make any money selling boomers to chemical supply companies. Hmmm…

[thelaughingmerman]

What did the osteoblast say to the osteocyte?