#osteoblasts

[bpod-bpod]

Cell Block

Cells are often on the move, but how they navigate obstacles is a little mysterious. Here researchers create a sort of assault course for young pre-osteoblasts – cells destined to develop into bone. A microscope zooms down from above capturing the scene after eight days of challenging growth around a hemispherical bump (cells seem to prefer valleys to mountains). But these cells, highlighted in red with DNA in blue, are adapting. They align their stress fibres – stretchy bundles of actin used to change their shape and direction. Researchers believe cells align some of their stress fibres in the direction of movement while others brace across the cell to limit bending. Cells working together means the tissue can reach out between these obstacles, like climbers strung together navigating a mountain pass (although a million times smaller). Such insights may suggest ways to support migrating cells during development, or tissues remodelling after injury.

Written by John Ankers

Video from work by Sebastien J. P. Callens and colleagues

Department of Biomechanical Engineering, Delft University of Technology (TU Delft), Delft, The Netherlands

Video originally published with a Creative Commons Attribution 4.0 International (CC BY 4.0)

Published in Nature Communications, March 2023

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[biology-geology-beaches-india]

The Science Research Manuscripts of S. Sunkavally, page 327.

[medicomunicare]

About blasts, clasts and receptors: PT H in the bone cannot be erased, yet GPRC5 is not tALK-3 with other signals

Osteoporosis is a skeletal condition that leads to the weakening of bones, making them porous, fragile, and prone to breakage. A whopping 8.9 million fractures are caused by osteoporosis annually. The aging population is the most vulnerable to primary osteoporosis, given, their frailty, and often, requires long-term therapy and support. Advances in healthcare and the corresponding rise in the…

[ziriamcaps]

been playing this indie rpg called Osteoblasts you're a skeleton recently resurrected by a Cat Witch and the first dungeon and score of enemies u fight are demon dogs lmao

[thestorybotsfanlol]

Bone Cells

I will try to draw the other types of cells without having an artblock

[aturinfortheworse]

Learning about hormones is funny because they're all named after what they do (like "growth hormone." guess what that fucker does) so it should be easy to remember them, except that most of them have such specific niche jobs that's actually no help at all. Oh yeah sure "lutenizing hormone" I totally know what that means and what it does. I fucking love to lutenize. Catch me out here lutenizing all day long with my buddy Lutenizing Hormone.

[sandwichedbread]

[a-simple-bacterium]

So like, everything in the body is made out of basically the same stuff right? So when something breaks and gets destroyed, who clears the rubble? Where does it go? Does a phagocyte eat it? Do you sometimes take a walk and Ms Macrophage is trying to gnaw on conk crete? Has a neutrophil eaten a door? So many questions

[staceymatch]

Osteoblast

[harmandip]

" 5 Crucial Roles Vitamin D(Sunshine Vitamin) Plays in Maintaining Strong Bones"

Vitamin D, often referred to as the “sunshine vitamin,” is a crucial nutrient that plays a pivotal role in maintaining optimal bone health. Beyond its association with sunlight, this vitamin is essential for various bodily functions. Let’s delve into the five significant reasons why vitamin D is indispensable for the strength and well-being of our bones. Calcium Absorption: Vitamin D facilitates…

[bpod-bpod]

Fractured Relationships

Break a bone and a frenzy of activity ensues to repair it. Bone-forming cells (osteoblasts) and their precursors (osteoprogenitors) take charge. However, fractures don’t always heal well. Consequently, growth factors are sometimes given to promote healing, specifically BMP which promotes bone formation and PDGF-BB which maintains osteoprogenitor numbers. Researchers investigate how they work in a mouse bone fracture model. MicroCT of fractured bones (pictured) revealed that adding high dose BMP, low dose BMP or PDGF-BB (top, left to right) promoted bone regeneration compared with no treatment (bottom left) or combining different BMP doses with PDGF-BB (bottom middle and right). Analysing the cell types revealed that BMP2 alone increased osteoblast and osteoprogenitor numbers but failed to do so when combined with PDGF-BB. While separately BMP2 and PDGF-BB promote bone healing, together they have the opposite effect. Further unpicking their interactions may help advance bone healing treatments.

Written by Lux Fatimathas

Image adapted from work by Sanja Novak and colleagues

Center for Regenerative Medicine and Skeletal Development, UConn Health, Farmington, CT, USA

Image originally published with a Creative Commons Attribution 4.0 International (CC BY 4.0)

Published in npj Regenerative Medicine, January 2023

You can also follow BPoD on Instagram, Twitter and Facebook

[valdevia]

Postmortem cross-section of a femur affected with bone pearls, also known as osteoperlomas.

While initially harmless, these shimmering benign tumors can lead to major fractures. Despite this, bone pearls have been prized throughout history, leading some to induce their formation for later harvesting.

Bone pearls are usually induced by injecting small calcium carbonate impurities into the bloodstream. They become embedded in the bone tissue and cause abnormal osteoblast growth, leading to osteoperlomas.

Surgical induction may also be performed to obtain pearls of the desired shapes.

[regexkind]

I go in for an X-ray and an anomaly is revealed. Zooming in, they see that the osteoblasts seem to be oriented fairly regularly, in either a vertical or horizontal orientation once a particular frame of reference is chosen. When assembled linearly, a binary sequence forms that is a triprime in length; the three primes represent the width, height, and frame count of a video encoded in the osteoblasts; half of the video is furry pornography, and the other half appears to be visual noise. The visual noise is then revealed to actually encode base pairs for a protein, and the protein is actually a contagious prion disease that turns anyone who becomes infected into a pervert

[humancelltournament]

Propaganda!

Adipocytes, also known as lipocytes and fat cells, are the cells that primarily compose adipose tissue, specialized in storing energy as fat. Adipocytes are derived from mesenchymal stem cells which give rise to adipocytes through adipogenesis. In cell culture, adipocyte progenitors can also form osteoblasts, myocytes and other cell types. There are two types of adipose tissue, white adipose tissue (WAT) and brown adipose tissue (BAT), which are also known as white and brown fat, respectively, and comprise two types of fat cells.

The X chromosome is one of the two sex chromosomes in many organisms, including mammals, and is found in both males and females. It is a part of the XY sex-determination system and XO sex-determination system. The X chromosome was named for its unique properties by early researchers, which resulted in the naming of its counterpart Y chromosome, for the next letter in the alphabet, following its subsequent discovery.

[alexanders-pokemon-adventure]

The Mending

Alexander Esparza felt weak. In their mind and in their bones and in their power. They were recovering from what could best be described as a posioning that had left Alex comatose for more than a mouth. It had reaked havoc in their body, the inactivity and the Shadows-energy.Alex wasn’t sure what had done worse.their had been a time shortly after their release from the hospital were they truly though they would never recover. Their whole body had ached constantly, their stamina and strength had disappeared ,sleep eluded them and hunger never seamed to call. In the place inside them were their power had been was dredged empty leaving only a hallow place that Alexander could always feel. Suffice to say it had been a bad time.

A rather unpleasant incident had happened when Alex had volunteered at Foster Island for their summer camp program were a fun battle between friend had almost unleashed the same force that hand ruined Alexander.

Things had gotten better though ,their friends Lynn and Ellisa (@adventures-on-foster-island )had seen through Alexander’s attempt to hide the severity of their condition completely . Bye the end of their trip Ellisa had sent home with Alexander a knew friend. A trained service Pokémon,a Clefable Alexander had named Hearts. she had been invaluable in the following weeks. They sang to help Alex sleep, and they did restful and energizing. When the shards of Alexander’s mind poked at them at unreasonable times Hearts would rub their temples and calm their thoughts, reminding them to eat even if alexander’s appetite had not truly returned yet. They were getting better in a way they could feel but still Alexander felt weak. They had been warned. “threats are coming” had been The final message of their dearest friends in the nowhere place where their consciousness had been in the moments of their death. Alexander could not help the feeling that they were running out of time. they needed to expedite this process. Fortunately, they had an idea Life Dew was part Hearts moveset, on their worst days Hearts would use that move to alleviate their aches and pains but Life Dew was more than just an analgesic. It measurably quickens the healing process and Hearts diligent in their ministrations, was happy to teach Bud her healing techniques.

So Alexander sat between them and explain what they want both Pokémon to do. Uses Life Dew For as long as they could on them Alexander would do the rest.

Bud and Hearts first glowed a luminous turquoise before pouring that light on Alexander. As they had done so many times Alexander Close their eyes, and took in energy and made it theirs. Life Dew was a water-type move, and its energy reflected it’s liquid nature . It filled the vessel that was Alexander’s body without fuss or issue. Flashes of Buds and Hearts, thoughts and intentions rushed into Alexander with the power they took in. Determination was at the front of all their minds. Life Dew what is a useful, if non-specific ability it would spread across its target bodies diluting and thinning to touch every part in need or not. Like a drop of food dye spread out in the roughly 45 quarts of water that roughly made up Alexander. Alex thought that was simply wasteful. It could do so much more if they could, will it to focus on a specific areas in higher concentrations. The effort made Alexander’s head hurt, but it went where they willed it. First to their bones that had decalcified in there coma , The turquoise light forced osteoblasts cell into overdrive , bone that had been weakened before strengthened as their density increased. It hurt Alex thought clenching their teeth ,human bodies weren’t meant to change so drastically, but more changes were coming. Alexander’s companions poured more turquoise light into them as they willed it to move again from bones to the circulatory system. Vessels and veins that had weekend while they had been unable to eat during their coma, and had no appetite in the weeks following shored up damaged , overstretched and weakened walls, capillaries that have disappeared from there inactivity tunneled through their body. this change had not hurt the same as the bones, but their fingers and toes stung as a new channels formed near nerves. their head was beginning to throb now, and Alex could feel his companions beginning of the tire but still turquoise light poured. The last place Alexander willed that power to go was their muscles ,tendons ,and ligaments. Dense , complicated tissues that anchors had degraded and mobility has been compromised. They simply had to be fixed ,if what was coming with his bad as Alexander imagined, they could not be the tripping bumbling mess they had been since their awakening. Oh, this was awful, was the only coherent thought Alexander could form as they forced muscle cords to break and reform stronger than before, for ligaments that had torn and overstretched to restructure themselves stronger than before and for tendons to re-anchor themselves in the bone. With their eyes still closed, Alexander felt two forms slouch against their body opening their eyes, Alex saw their two companions had collapsed against them snoring heavily. Alexander’s body hurt unquestionably and new in a few moments, they would join their companions in sleep, but underneath it, in all the places they had re-forged with their friends, they felt very alive.