#or infectious diseases

[cynically-optomistic]

I dont think there should be a time frame on panic actually

[dsudis]

Help win cleaner indoor air!

The Airborne Act (H.R. 9000) creates incentives to clean up indoor air! It offers tax credits to commercial building owners for conducting indoor air quality assessments and making upgrades to ventilation and air filtration.

Indoor air quality upgrades can reduce substantially airborne diseases—protecting our health and decreasing health care expenses, lost wages and lost productivity.

[gumjrop]

This year’s flu shot will be missing a strain of influenza it’s protected against for more than a decade.

That’s because there have been no confirmed flu cases caused by the Influenza B/Yamagata lineage since spring 2020. And the Food and Drug Administration decided this year that the strain now poses little to no threat to human health.

Scientists have concluded that widespread physical distancing and masking practiced during the early days of COVID-19 appear to have pushed B/Yamagata into oblivion.

This surprised many who study influenza, as it would be the first documented instance of a virus going extinct due to changes in human behavior, said Dr. Rebecca Wurtz, an infectious disease physician and epidemiologist at the University of Minnesota School of Public Health.

“It is such an interesting and unique story,” Wurtz said, adding that if it were not for COVID, B/Yamagata would still be circulating.

One reason COVID mitigation efforts were so effective at eliminating B/Yamagata is there was already a fair amount of immunity in the population against this strain of flu, which was also circulating at a lower level, said Dr. Kawsar Talaat, an infectious disease physician at Johns Hopkins Bloomberg School of Public Health.

In contrast, SARS-CoV-2 was a brand new virus that no one had encountered before; therefore, masking and isolation only slowed its transmission, but did not stop it.

The absence of B/Yamagata won’t change the experience of getting this year’s flu shot, which the Centers for Disease Control and Prevention recommends to everyone over 6 months old. And unvaccinated people are no less likely to get the flu, as B/Victoria and two influenza A lineages are still circulating widely and making people sick. Talaat said the disappearance of B/Yamagata doesn’t appear to have lessened the overall burden of flu, noting that the level of illness that can be attributed to any strain varies from year to year.

The CDC estimates that between 12,000 and 51,000 people die every year from influenza.

However, the manufacturing process is simplified now that the vaccine is trivalent — designed to protect against three flu viruses — instead of quadrivalent, protecting against four. That change allows more doses to be produced, said Talaat.

Ultimately, the costs of continuing to include protection against B/Yamagata in the flu shot outweigh its benefits, said Talaat.

"If you include a strain for which you don't think anybody's going to get infected into a vaccine, there are some potential risks and no potential benefits," she said. "Even though the risks might be infinitesimal, the benefits are also infinitesimal."

Scientists and public health experts have discussed for the past couple years whether to pull B/Yamagata from the flu vaccine or wait for a possible reemergence, said Kevin R. McCarthy, an assistant professor at the University of Pittsburgh's Center for Vaccine Research. But McCarthy agrees that continuing to vaccinate people against B/Yamagata does not benefit public health.

Additionally, there is a slight chance of B/Yamagata accidentally infecting the workers who manufacture the flu vaccine. The viruses, grown in eggs, are inactivated before being put into the shots: You cannot get influenza from the flu shot. But worker exposure to live B/Yamagata might occur before it's rendered harmless.

That hypothetically could lead to a reintroduction of a virus that populations have waning immunity to because B/Yamagata is no longer making people sick. While that risk is very low, McCarthy said it doesn’t make sense to produce thousands of gallons of a likely extinct virus.

It is possible that B/Yamagata continues to exist in pockets of the world that have less comprehensive flu surveillance. However, scientists aren’t worried that it is hiding in animals because humans are the only host population for B lineage flu viruses.

Scientists determined that B/Yamagata disappeared in a relatively short period of time, and this in and of itself is a success, said McCarthy. That required collaboration and data sharing from people all over the world, including countries that the U.S. has more tenuous diplomatic relationships with, like China and Russia.

“I think the fact that we can do that shows that we can get some things right,” he said.

Sarah Boden is an independent health and science journalist based in Pittsburgh.

[thehappyvet]

Where do people get this misconception that every single wildlife case at a vet clinic is euthanased so it's better to not take them in even if they're obviously hurt or sick and in need of treatment?!?!

Friendly reminder that a member of the public should not be able to easily pick up or catch a wild animal. We are not in a disney movie. If you can pick it up*, 80% of the time its extremely hurt or sick.

Wildlife, and most animals for that matter, do not show pain as humans do. That does not mean they are not in pain and suffering.

Veterinarians only euthanase wild animals that are suffering from extreme injury or illness, or animals that would stress themselves to death in a hospital setting that cannot be released and survive in the wild with their issue.

We do euthanase some animals, but that's because it's the best welfare decision for that animal and its specific problem.

Maybe trust the professionals trained in providing treatment to animals instead of some Karen on Facebook who demonises vets because she can't understand a bird with multiple wing and shoulder fractures is very unlikely to regain flight and return to the wild and her plan of keeping it means it will live a life of chronic pain and suffering.

*Disclaimer: If you live in a country where diseases such as rabies are endemic, you should not handle wildlife at all if you are not trained or vaccinated. This post is not recommending members of the public handle wildlife in any country.

[reasonsforhope]

"Since it was first identified in 1983, HIV has infected more than 85 million people and caused some 40 million deaths worldwide.

While medication known as pre-exposure prophylaxis, or PrEP, can significantly reduce the risk of getting HIV, it has to be taken every day to be effective. A vaccine to provide lasting protection has eluded researchers for decades. Now, there may finally be a viable strategy for making one.

An experimental vaccine developed at Duke University triggered an elusive type of broadly neutralizing antibody in a small group of people enrolled in a 2019 clinical trial. The findings were published today [May 17, 2024] in the scientific journal Cell.

“This is one of the most pivotal studies in the HIV vaccine field to date,” says Glenda Gray, an HIV expert and the president and CEO of the South African Medical Research Council, who was not involved in the study.

A few years ago, a team from Scripps Research and the International AIDS Vaccine Initiative (IAVI) showed that it was possible to stimulate the precursor cells needed to make these rare antibodies in people. The Duke study goes a step further to generate these antibodies, albeit at low levels.

“This is a scientific feat and gives the field great hope that one can construct an HIV vaccine regimen that directs the immune response along a path that is required for protection,” Gray says.

-via WIRED, May 17, 2024. Article continues below.

Vaccines work by training the immune system to recognize a virus or other pathogen. They introduce something that looks like the virus—a piece of it, for example, or a weakened version of it—and by doing so, spur the body’s B cells into producing protective antibodies against it. Those antibodies stick around so that when a person later encounters the real virus, the immune system remembers and is poised to attack.

While researchers were able to produce Covid-19 vaccines in a matter of months, creating a vaccine against HIV has proven much more challenging. The problem is the unique nature of the virus. HIV mutates rapidly, meaning it can quickly outmaneuver immune defenses. It also integrates into the human genome within a few days of exposure, hiding out from the immune system.

“Parts of the virus look like our own cells, and we don’t like to make antibodies against our own selves,” says Barton Haynes, director of the Duke Human Vaccine Institute and one of the authors on the paper.

The particular antibodies that researchers are interested in are known as broadly neutralizing antibodies, which can recognize and block different versions of the virus. Because of HIV’s shape-shifting nature, there are two main types of HIV and each has several strains. An effective vaccine will need to target many of them.

Some HIV-infected individuals generate broadly neutralizing antibodies, although it often takes years of living with HIV to do so, Haynes says. Even then, people don’t make enough of them to fight off the virus. These special antibodies are made by unusual B cells that are loaded with mutations they’ve acquired over time in reaction to the virus changing inside the body. “These are weird antibodies,” Haynes says. “The body doesn’t make them easily.”

Haynes and his colleagues aimed to speed up that process in healthy, HIV-negative people. Their vaccine uses synthetic molecules that mimic a part of HIV’s outer coat, or envelope, called the membrane proximal external region. This area remains stable even as the virus mutates. Antibodies against this region can block many circulating strains of HIV.

The trial enrolled 20 healthy participants who were HIV-negative. Of those, 15 people received two of four planned doses of the investigational vaccine, and five received three doses. The trial was halted when one participant experienced an allergic reaction that was not life-threatening. The team found that the reaction was likely due to an additive in the vaccine, which they plan to remove in future testing.

Still, they found that two doses of the vaccine were enough to induce low levels of broadly neutralizing antibodies within a few weeks. Notably, B cells seemed to remain in a state of development to allow them to continue acquiring mutations, so they could evolve along with the virus. Researchers tested the antibodies on HIV samples in the lab and found that they were able to neutralize between 15 and 35 percent of them.

Jeffrey Laurence, a scientific consultant at the Foundation for AIDS Research (amfAR) and a professor of medicine at Weill Cornell Medical College, says the findings represent a step forward, but that challenges remain. “It outlines a path for vaccine development, but there’s a lot of work that needs to be done,” he says.

For one, he says, a vaccine would need to generate antibody levels that are significantly higher and able to neutralize with greater efficacy. He also says a one-dose vaccine would be ideal. “If you’re ever going to have a vaccine that’s helpful to the world, you’re going to need one dose,” he says.

Targeting more regions of the virus envelope could produce a more robust response. Haynes says the next step is designing a vaccine with at least three components, all aimed at distinct regions of the virus. The goal is to guide the B cells to become much stronger neutralizers, Haynes says. “We’re going to move forward and build on what we have learned.”

-via WIRED, May 17, 2024

[thecrashcourse]

Premiering today at 12 pm ET: the first ever Crash Course Lecture! Join us and guest lecturer John Green in the live chat as we learn about the history and science of #tuberculosis and how we can #StopTB

Crash Course Lectures are individual long-form videos that dive deep into a topic in a multidisciplinary way. As always at Crash Course, we embrace curiosity. We hope learners of all kinds enjoy these lectures, and that you are inspired to continue learning about the topic even after the video ends!

[tomorrowusa]

People need to be reminded of Trump's woeful incompetence which came to a head during the pandemic emergency and resulted in the unnecessary deaths of hundreds of thousands of Americans.

The Obama administration successfully dealt with the threats from swine flu and Ebola. There was no swine flu disaster, there was no Ebola disaster, and there was even no Zika disaster because competent people were running the US. Near the end of Obama's term, his National Security Council staff put together a 69-page playbook on how to deal with pandemic emergencies. It's called "Playbook for Early Response to High-Consequence Emerging Infectious Disease Threats and Biological Incidents". Of course Trump ignored the document and plunged the nation into COVID hell.

Trump team failed to follow NSC’s pandemic playbook

Michelle Obama, in one of her best speeches ever in Kalamazoo this weekend, excoriated Trump's incompetence.

Michelle Obama laced into Donald Trump in a searing speech in Michigan on Saturday, accusing the former president of “gross incompetence” and having an “amoral character” while challenging hesitant Americans to choose Kamala Harris for US president. “By every measure, she has demonstrated that she’s ready,” the former first lady told a rapt audience in Kalamazoo. “The real question is, as a country, are we ready for this moment?” [ ... ] In raw and strikingly personal terms, she asked why Harris was being held to a “higher standard” than her opponent. Trump’s handling of the Covid-19 pandemic and his failed attempt to cling to power after losing the 2020 election should alone be disqualifying, Obama argued. But now the people who worked closest with him when he was president – his former advisers and cabinet secretaries – had stepped forward with a warning that he should not be allowed to return to power.

ICYMI, here is Michelle Obama's speech in Michigan.

Too many people have been afflicted by Trumpnesia. They seem to have forgotten the catastrophe that happened starting on 22 January 2020 when the first COVID infection was discovered on US soil. On that day Trump told CNBC: "we have it totally under control" and "it's going to be just fine".

Instead of following Playbook for Early Response to High-Consequence Emerging Infectious Disease Threats and Biological Incidents, Trump did the usual bullshit Trump things like criticize the Oscars and rage-tweet from the bathroom. He belatedly declared a state of emergency on Friday the 13th of March – the day after the stock market crashed.

Don't let anybody in real life get away with describing the Trump years as some sort of utopia.

Some people disingenuously claim they don't know enough about Kamala Harris despite her 20 years in public service. We all know more than enough about Trump's egregious ineptitude which turned a national emergency into a prolonged national nightmare.

[amaditalks]

The thing that I will never get over nor forgive is the lying.

Enough white women lied to pollsters, phonebankers, and canvassers at their doors about voting for Harris against their husbands’ wishes, or wanting to vote for Harris but being concerned about what their Trump supporting husbands would do that an entire PSA campaign arose, and talking points went out to phone bankers from every organization to remind those women that their votes were private and that their husbands could never find out who they voted for.

But then those white women went out and they voted for the rapist in almost the exact same percentages as they did in the last two elections. 

Why all the performance? It feels like an intentional ratfucking effort.

There is a pernicious moral rot and an integrity vacuum amongst white voters. And it’s only other white people who can fix that.

[nando161mando]

COVID denialism and misinformation has led to Olympic athletes not even washing their hands because they wrongly think it will help them become more resistant against disease.

There is no evidence handwashing weakens your immune system. There is no evidence that adopting unsanitary practices makes your immune system stronger. But there is a lot of evidence that handwashing and other precautions protects you and others from infectious diseases, especially in risky environments like bathrooms.

https://www.reddit.com/r/HermanCainAward/

https://www.sorryantivaxxer.com/

[x-x-angel]

What if I just.. yes this is a new Handplates infection au called Necrophobia (The fear of corpses and dead things), in this au the skele brother’s encounter these 2 doppelgängers roaming around the lab while testing, there is a gaster doppelgänger that is unidentified,

Handplates by @zarla-s

[chronicsheepdeprivation]

There's a possible effective treatment for the Amphibian Chytrid Fungus!

This fungus has been the cause of devastating mass deaths and extinctions in several frog species but now we have a way to help combat it!

[sizzlingsandwichperfection-blog]

Me and my friends have a monthly game night, where we play a game or competition, and the loser has to make a donation to a charity of the winners choosing. Next month is gonna be racing Go-Karts, and I've got this in the bag. Are there any TB related charities you would recommend I send my friends to?

YES. The folks leading the charge at expanding treatment access are:

The Stop TB Partnership

MSF

Partners in Health

The Treatment Action Group (which was founded by ACT UP but has now expanded to seek better treatment for people living with TB as well as HIV).

[3dfeels]

at this point i think i own wolfwood as my own personal cowboy character

[gumjrop]

Make your voice heard and ask the CDC to:

Recommend COVID vaccines for all ages and health statuses at least twice a year (spring vaccine access for all) AND

Support more frequent updates to the vaccines, adjusted for the latest variants.

Submit a public comment using our sample language below.

The committee is anticipated to vote on the following topic on day 1 of the meeting (October 23): “Use of additional doses of COVID-19 vaccine in immunocompromised individuals and older adults following an initial dose of 2024–2025 vaccine”

Your comments make a difference. At this committee’s June 2024 meeting, public comments from our community led to the committee’s decision to make fall COVID vaccines available to people of all ages, rather than limiting eligibility to specific risk groups. Please join us in making your voice heard for spring COVID vaccine access for all, and at least twice a year access going forward.

Submit Written Comment

You can also register to give Oral Public Comment at the upcoming online CDC ACIP Meeting October 23-24 at: https://www2.cdc.gov/vaccines/acip/acip_publiccomment.asp 

Submit written comments and/or register to make oral comments at the meeting by Friday October 18 at 11:59pm Eastern Standard Time.

It’s important to submit a personalized comment, which can be brief. Ideas for a personalized comment:

How you, your family, or your community would be impacted by spring vaccine eligibility being restricted to only high risk groups (such as older age or immunocompromised status)

Barriers to vaccination your have faced, particularly if your eligibility was questioned or misinterpreted by a vaccine provider

How out-of-pocket costs are a barrier to getting the latest vaccines

Also feel free to take inspiration from or borrow the language in our sample public comment below.

Step-By-Step Submission Instructions:

Step 1. Go to the Regulations.gov to submit your comment.

Step 2. Type in your comment under the field, “Comment.”

Step 3 (optional). Submit a PDF or Word version of your comment under, “Attach Files.”

Step 4. Select either “Individual” or “Anonymous” depending on if you want to share your personal identifiable information that will be publicly available on the Federal Register.

Step 5. If selecting “Individual,” minimally provide your first and last name. If selecting “Anonymous” you can directly submit the comment without sharing your personal identifiable information. Click “Submit Comment.”

Example Comment:

Docket No. CDC-2024-0072-0001 COVID vaccination at least twice a year (at least every six months) must be recommended for people of all ages, regardless of health status. A restrictive approach to eligibility creates undue barriers for vulnerable people and discourages high risk people from getting needed vaccine boosters. People of all ages, including those who are aged 65 and older or immunocompromised, should have the opportunity to receive another COVID vaccine in the spring of 2025. The vaccine schedule should address waning efficacy in the months following vaccination [1-3] as well as emergence of new SARS-CoV-2 strains by recommending updated vaccination for all ages, at least every six months. Waning efficacy is seen with all COVID vaccine types, and recent research into the biological mechanisms of waning [4] supports that this effect occurs regardless of age or immunocompromised status. Recent vaccination is associated with a lower risk of developing Long COVID following a COVID infection [5] as well as a lower risk of Multisystem Inflammatory Syndrome in children (MIS-C) [6].  The CDC’s clear and unequivocal recommendation of COVID vaccination at least twice a year for all ages will influence recommendations by healthcare providers, and coverage by health insurance. Moreover, it will improve public awareness in people of all ages about the importance of recent vaccination (within the last six months) to provide the best protection as part of a multilayered approach to preventing illness. The CDC must ensure equitable and affordable access to updated vaccines and prevent limited access because of financial constraints or demographics. The CDC’s Bridge vaccine access program ended in August 2024 [7], leaving many uninsured and underinsured adults without COVID vaccine access. We ask you to advocate for free COVID vaccine access for all of us to reduce barriers and hesitation to vaccination. References: 1. Link-Gelles R. Effectiveness of COVID-19 (2023-2024 Formula) vaccines. Presented at: FDA VRBPAC Meeting; June 5, 2024. Accessed June 12, 2024. https://www.fda.gov/media/179140/download 2. Wu N, Joyal-Desmarais K, Vieira AM, et al. COVID-19 boosters versus primary series: update to a living review. The Lancet Respiratory Medicine. 2023;11(10):e87-e88. doi:10.1016/S2213-2600(23)00265-5 3. Menegale F, Manica M, Zardini A, et al. Evaluation of Waning of SARS-CoV-2 Vaccine–Induced Immunity: A Systematic Review and Meta-analysis. JAMA Netw Open. 2023;6(5):e2310650. doi:10.1001/jamanetworkopen.2023.10650 4. Nguyen DC, Hentenaar IT, Morrison-Porter A, et al. SARS-CoV-2-specific plasma cells are not durably established in the bone marrow long-lived compartment after mRNA vaccination. Nat Med. Published online September 27, 2024:1-10. doi:10.1038/s41591-024-03278-y 5. Fang Z, Ahrnsbrak R, Rekito A. Evidence Mounts That About 7% of US Adults Have Had Long COVID. JAMA. Published online June 7, 2024. doi:10.1001/jama.2024.11370 6.  Yousaf AR. Notes from the Field: Surveillance for Multisystem Inflammatory Syndrome in Children — United States, 2023. MMWR Morb Mortal Wkly Rep. 2024;73. doi:10.15585/mmwr.mm7310a2 7. https://www.cdc.gov/vaccines/programs/bridge/index.html 

Full instructions for written and oral comment and meeting information can be found at: https://www.cdc.gov/acip/meetings/

You can also register to give Oral Public Comment at the upcoming online CDC ACIP Meeting October 23-24 at: https://www2.cdc.gov/vaccines/acip/acip_publiccomment.asp 

You must register by October 18 at 11:59pm Eastern Standard Time

CDC’s ACIP meeting information on the Federal Register: https://www.federalregister.gov/documents/2024/09/30/2024-22357/meeting-of-the-advisory-committee-on-immunization-practices 

Full Statement:

Vaccination with the latest updated vaccines continues to be foundational to a multilayered approach to COVID, providing protection against both acute disease and Long COVID. Far too few Americans have received the latest vaccines. As of October 11, 2024, only 11.2% of all adults and 26.7% of adults aged 65 and older had received an updated 2024-2025 COVID vaccine. Data for children were unavailable at the time of this writing (October 15, 2024). COVID vaccination rates continue to lag behind influenza vaccination rates. As of July 27, 2024, only 9% of adults aged 65 and older received the recommended two doses of last year’s 2023-2024 vaccine.

Vaccine efficacy wanes significantly four to six months following vaccination, making updated vaccination important for all people as COVID continues to spread in our communities. Vaccine approaches that restrict access based on age or risk status put all of us at risk and leave those at high risk of severe consequences of COVID infection confused about whether they qualify to receive additional doses. These high risk patients may also face barriers as vaccine providers misunderstand the guidelines. A more frequent vaccination approach providing vaccination at least every six months as well as frequent updates to match current variants is needed to better protect all of us amid year-round COVID spread.

Recent vaccination is associated with a lower risk of developing Long COVID following a COVID infection as well as a lower risk of Multisystem Inflammatory Syndrome in children (MIS-C). Waning efficacy is seen with all COVID vaccine types, and recent research into the biological mechanisms of waning supports that this effect occurs regardless of age or immunocompromised status. 

The CDC’s Bridge Access Program, which previously provided COVID vaccines to uninsured and underinsured adults free of charge, ended in August 2024. The end of this program without replacement coverage puts people at risk, and public health officials must advocate for free vaccine access for all of us, including those who are uninsured and underinsured.

Submitted written comments or registration to make oral comments at the meeting must be received by the CDC no later than October 18 at 11:59pm Eastern Standard Time

[macgyvermedical]

Incubation Periods List

Hi all!

The following is a list of incubation periods for various infectious diseases for all your writing needs. An incubation period is the amount of time between exposure to an infectious agent (bacteria, virus, protozoa or prion) and the person having the first symptoms of the resulting illness. Knowing this is helpful in creating a timeline for your story.

Anthrax: Incubation period of 1-60 days

Avian Flu: Incubation period 3-9 days

Botulism: Incubation period 12-72 hours

Chikungunya: Incubation period 3-7 days

Chlamydia: incubation period 7-21 days

COVID-19: Incubation period 5-10 days

Creutzfeldt-Jacob Disease: Incubation period 10-20 years

Dengue: Incubation period 5-7 days

Diphtheria: Incubation period 2-5 days

Ebola: Incubation period 2-21 days

Hantavirus: incubation period 1-8 weeks

Hepatitis A: incubation period about 28 days

Herpes: Incubation period 2-12 days

Herpes Zoster/Varicella (Chickenpox): Incubation period 14-16 days

Herpes Zoster (Shingles): Incubation period- technically none, as this is a reactivation of the virus that causes chickenpox

HIB: Incubation period 2-10 days

HIV: Incubation period 1-6 weeks to prodrome, approximately 10 years to AIDS

Influenza: Incubation period 1-4 days

Legionnaires Disease: Incubation period 5-6 days

Leprosy: Incubation period 9 months to 20 years

Lyme Disease: Incubation period 3-30 days

Malaria: Incubation period 7-30 days

Measles: Incubation period 10-12 days

Meningitis, Bacterial: Incubation period 2-10 days

Meningitis, Viral: Incubation period 3-10 days

Monkeypox: Incubation period 1-2 weeks

Mumps: Incubation period 16-18 days

Norovirus: Incubation period 12-48 hours

Pertussis: Incubation period 7-10 days

Plague: Incubation period 2-8 days

Pneumococcal Pneumonia: Incubation period 1-3 days

Polio: Incubation period 7-10 days

Q-Fever: Incubation period 2-3 weeks

Rabies: Incubation period 20-90 days

RSV: Incubation period 4-6 days

Smallpox: Incubation period 7-17 days

Syphilis: Incubation period 10-90 days

Tetanus: Incubation period 3-21 days

Tuberculosis: Incubation period 2-10 days

Typhoid: Incubation period 6-30 days

Typhus: Incubation period 1-2 weeks

West Nile Virus: Incubation period 2-6 days

Yellow Fever: Incubation period 3-6 days

Zika: Incubation period 3-14 days

[slavhew]

28/01/2024

stars don't twinkle moon doesn't shine

big thanks to @nahrgles for finishing this for me after i hit a wall with colors bg and effects- chromatic aberration blew my fkn mind

pre edit transparent version under cut because i spent too much time cleaning it loll