#natural cancer treatment centers

[cancerhealingretreats]

Natural Cancer Treatment Centers | Cancer Healing Retreats

Visit Natural Cancer Treatment Centers to Learn About Holistic Healing. Cancer Healing Retreats' knowledgeable medical professionals and therapists are picked for their special abilities in identifying and treating the underlying causes of cancer. Join us on a thorough, holistic trip that combines their knowledge with tranquil settings to promote total wellbeing and rejuvenation. Join us in embracing healing and optimism.

[samskrt]

Revolutionizing Cancer Treatment: The Ayurvedic Approach to Holistic Healing

[pejite]

Hi! Today, I’m sharing a list of mods that I consider essential for playing historical gameplay in The Sims.

I often have friends who want to dive into the Decades Challenge but aren’t sure which mods to use or where to start. So, in this post, I’m going to share the mods I personally use and think are indispensable for creating that authentic historical experience.

Deaderpool's MC Command Center: This mod allows you to manage and modify many aspects of your game, including handling pregnancies, university careers, and enabling teen relationships so your Sims can marry earlier, among other features. You can also enable autosave and adjust the length of a Sim day.

Lumpinou's RPO: This mod enhances relationship dynamics and expands pregnancy features. It's extensive, with many modules, and once you've tried it, you won't want to play without it.

Pandasama's Realistic Childbirth: Offers multiple realistic childbirth options, including natural bed births and spontaneous labour, adding depth to your Sims' family lives.

MizoreYukii's Arranged Marriages: Allows you to arrange marriages for convenience. Parents can agree on marriages for their children, but breaking the arrangement won’t be easy.

Necrodog's Carriages and Horses: Adds functional carriages, enhancing immersion. While it doesn't work with the horses of Horse Ranch pack, it’s still incredibly useful.

Kuttoe's Enlist in War: It will allow your Sims to enlist in the war. Whether they live or die will be random, but if they survive, they'll receive the Veteran trait, a lifetime pension and some lasting traumas.

JaneSimsten's Regency Romance: Perfect for simulating the Regency era. It adds class differences, property ownership, etiquette skills, new traits and careers, events, and widowhood. Though inspired by the Regency era, it works well for later decades too.

SimKatu's Reading Animation Override: Changes the reading animations, with different ones for men and women, making your Sims’ reading time more immersive.

Zero's Deadly Dickensian Sicknesses: Introduces the risk of diseases like Tuberculosis, Typhoid Fever, and Cholera. It’s incredibly realistic with its contagion system.

Adeepindigo's Healthcare Redux: A comprehensive health mod that adds various illnesses and treatments, including tuberculosis and (early access) cancer. While Sims can buy modern medicines, many illnesses can be cured with natural remedies.

Adeepindigo's Simulated Endings: This mod will enhance everything related to your Sims' deaths, allowing them to take out life insurance and designate beneficiaries, arrange funeral preparations, and introduce stages of grief for your Sims.

MizoreYukii's Functional Broom: Adds a functional broom with its own animation, letting you keep your Sims’ homes clean without resorting to modern vacuums.

Triplis's Quit or Join School: In case you need your teens or childs to quit school.

The Kalino's Farm Animal Set: Expands your farm with more animals, including goats, sheep, ducks and more, in addition to the standard cows and chickens.

JaneSimsten's Write With Quills: Replaces your Sims' pens with quills, adding a touch of historical accuracy.

JaneSimsten's Sidesaddle Override: Allows female Sims to ride horses sidesaddle, as they would have in the past.

JaneSimsten's Parchment Computer: Replaces modern computers with parchment and quills, complete with their own animations—perfect for pre-typewriter eras.

Frankk's Language Barriers: More realism to sims being from different worlds.

Rs4ella's 1920s Grade School Homework Override: Changes the look of the kids' homework book to a 1920s style, but it works well for earlier periods too.

Xbrilliantsims's Toddler Bathtime Overrides: Replaces modern bath toys and sponges with more era-appropriate items when bathing toddlers.

Lunamoth's Historical Infant Carriers: Swaps out modern baby carriers for fabric slings, suitable for any historical era.

Lunamoth's Rope Pet Leash: Replaces the modern pet leash with a simple rope, making it look more appropriate for historical gameplay.

300yearschallenge's Historical Baby Bath Override: Changes the baby bath seat to a more suitable design, or you can opt for

Sassymissollie's Invisible Infant Bath Seat to remove it entirely.

JaneSimsten's 5 Day Work Week: Choose Your Own Work Hours: Lets you adjust your Sims' work schedules for a more realistic experience.

JaneSimsten's Marksmanship Skill: Adds a marksmanship skill, allowing your Sims to practise shooting and hunting, with the hunted animals available for cooking.

Littlbowbub's Ye Olde Cookbook: Enables your Sims to cook historical dishes, perfect for low-income Sims in older settings.

Basemental's Basemental Drugs: Although mainly known for adding drugs, it’s commonly used for its smoking features, letting your Sims smoke cigarettes and cigars like a proper Victorian gentleman.

MizoreYukii's Children/Toddlers Can Die of Anything: Allows your child Sims to die, useful if your storyline requires it.

Ayoshi's Phone to Notebook Replacement Mod: If phone elimination mods are causing issues, this mod might help. It replaces the mobile phone with a small notebook, which could pass for a mini Bible or an old-fashioned notebook.

JaneSimsten's Extra Cross-Stitch Patterns: Adds historically accurate cross-stitch patterns.

[fastcardotmp3]

welcome to dot drops something that's been sitting in her tumblr drafts for 4 months Saturday I hope you enjoy your visit mwah! Steddie; Ballet AU; Dancer!Steve; mentions of cancer treatment; 1.5k words

Dress rehearsal is supposed to be a mess.

That's the point of it, really, to get all the mistakes out of your system and start the actual show run with a clean slate. Or at least, that had been the point of which they'd all convinced themselves when Steve was the one performing.

Bad dress meant good show, or so the old adage went, and so at least there was some ease of worry with the collective understanding that it won't happen on the night within the company.

That was the case when Steve was a student, when he was an apprentice, even during his time in the big leagues at Joffrey, but right now? At the end of a truly abysmal dress in this run-down theater on the edge of a town from which he'd once run away?

Steve is not the performer. He's the guy in charge.

And so he spirals.

He'd never wanted to be a director or an instructor or the head of a studio like this. It had never been in his plans. Steve was a man of action, where the people who do these jobs are the brains behind the operation.

Steve knows how to work hard, how to force his body and even his mind into submission until he gets the steps just right, but this? These past six months back in Hawkins temporarily helping out?

(God, please let it be temporary.)

He's not built for this. He's sitting center stage after everyone has left with only half the house lights to illuminate his misery and he's not. Built. For. This.

Not built for being a mentor or a leader or a role model; not built to handle the strenuous nature of his mother's legacy; not built to carry the name she's made for herself as a teacher and a choreographer and a shaper of young dancers.

Steve's not built for it!

They'd had a shitty fucking dress.

"Hey, uh, you gonna be a while? I kinda need to close up for the night."

The voice echoes across the empty space, bouncing off the high ceiling and straight up to land on the Marley floors at Steve's feet. The stage isn't built for dancers, much like Steve isn't built to be here, so they'd had to pull up the floors from the studio and drag them halfway across town just to roll them out here.

"Hello? Are you, like, alive up there?"

Steve sighs. "Yeah," he calls back, catching sight of the figure talking to him at the back of the theater, the young guy who runs the place and who Steve met a grand total of three days ago. His name is Eddie and he dresses more like he's running a music venue than a local community theater, but he's mostly stayed out of Steve's way so far. "Sorry, I'll get outta your hair."

"Sure," Eddie says, but he's just sort of leaning against the back wall by the window to the sound and lighting booth without an ounce of urgency to him as Steve drags himself to his aching feet and lugs his three separate bags of show stuff onto his shoulders.

There's an energy to an empty theater, one which has held a performance and one which now holds the ghosts of that performance, which tugs at the anxieties sitting buried deep beneath the more immediate ones.

Fears about his mom's health, about what will happen to the studio if she doesn't win this particular battle, about what will happen to him.

There's an energy here in the creak of the steps which lead down off the front of the stage and there's an energy to the plod of Steve's sneakers up the long, racked aisle between the seats.

There's an energy, but it's also not empty, is it.

"Hey, good show, dude," Eddie says, pushing off his wall as Steve grows nearer. "Like, talented kids you've got there."

Steve scoffs before he can help himself and then pinches the bridge of his nose in a grimace for not being able to help himself.

"Uh, yeah, thanks," he grits out, thinking about his bed. Thinking about how he never made time for dinner and he has to be here early again tomorrow.

"Wow, resounding confidence on this one," Eddie snorts, and when Steve opens his eyes it's to genuine amusement, genuine curiosity in the tilt of a head and furrow of a brow.

"No, just," he shakes his head, "you should see 'em when they're really on their game, y'know?"

Eddie hums, and when did Steve come to a stop right in front of him? He's leaving. He has to leave. Go home. Think about all the spacing corrections he needs to fix tomorrow and run through with the girls before show time.

"Bad dress, good show though, right?"

Steve startles. Maybe a little too visibly because Eddie is actively holding back laughter at the sight of him.

"What, I've worked at a theater for four years and I'm not supposed to pick up a thing or two about the ballet?" he snarks good-naturedly. "Caroline, the lady who did your job before you, she was a chatty one, taught me everything I know about Giselle."

It's a knife between the ribs. It's a soothing sort of heat, like from a roaring bonfire.

"You--" he clears his throat, "you know Caroline?"

"Highlight of the job honestly, before she retired," Eddie shrugs.

"She didn't retire."

"Oh. She...?"

"Chemo," Steve doesn't know why he's saying it all so willingly, why after months of trying to run the studio without having to talk about how's your mom doing, sweetheart? he's opening up to this stranger with the curly hair and curious eyes. But he knows her. He's-- Well, he knows her. "I'm just here to-- to fill in until she can come back. So."

Eddie is studying him now. Curious eyes turned intelligent, knowing, sad with the weight of realization.

"You're the wonder boy," he says on a breath like oh, I get it now.

"The what?" Steve balks.

"Her kid," Eddie says like it's simple. He's leaning against the wall again, like he's not planning on getting back to work anymore, "she was-- Shit, man, she loves the hell outta you. Oh, you should see my son, he's in Les Corsaire this season! Oh, my boy, he's just gotten promoted to soloist, he'll be a principal in no time! Oh, the talent on him, the--"

"Okay, okay, Jesus," Steve cuts him off, a half-hysterical laugh bubbling up out of his chest in the process.

"You should tell her I say hi next time you see her," Eddie isn't remotely deterred by having his little, lilting performance derailed. There's a softness to him that deserves a smaller space, walls less prone to echo.

"I will," Steve nods. His bags grow heavy on his shoulders.

"And you should chill out a little bit," he says, this time with the kind of glint to his eye that needs a bigger space, needs to be up on the stage to the point where it has Steve floundering, "y'know, about the the shitty dress that, between you and me," he leans in conspiratorially, close enough to feel the heat of his breath, "wasn't really all that shitty."

Steve sucks in a breath.

It strikes him somewhere old, the reassurance, somewhere young deep inside of him. The comforting from a mother that if he just works hard enough he’ll land that double tour in fifth some day soon, the unbroken promise that she would never give him special treatment as the son of the studio owner, but that she would never hesitate to reward him when he’d earned it on his own.

It strikes him because no one tells you how little reassurance the guy in charge is ever offered and it strikes him because it’s been such a long day and it strikes him because—

“Hey, have you had dinner yet?”

Eddie’s eyebrows lift high on his forehead and Steve sees it, the attitude on this dude that his mother absolutely would have loved in an instant. There’s a performer in there, even just in the brief interaction they’ve shared so far. There’s a spotlight pointing inwards and a show begging to be dragged out.

“No,” Eddie drags out slow and curious, “you offering, ballet boy?”

Steve needs a sounding board and he needs another set of eyes and he needs his mom to be okay and the show tomorrow to prove that he can handle this for her if she’s not, but maybe what he needs most right now, on the other side of a spiral in a dark and echoing theater, is this.

“Meet me at Benny’s in thirty,” he says simply as he makes his way for the door. “Since you’re such an experienced test audience.”

Eddie’s responding laugh is bright and his eyes glitter with curious amusement and maybe this is what Steve needs because maybe all of this is one big rehearsal at a big new life in and old small town.

And maybe this is his chance to make a mess of it. At least until the real show starts.

[mindblowingscience]

Periods of fasting reprogram the immune system's natural killer cells to better fight cancer, according to a new study in mice from researchers at Memorial Sloan Kettering Cancer Center (MSK). Fasting and other dietary regimens are increasingly being explored as ways to starve cancer cells of the nutrients they need to grow and to make cancer treatments more effective. Now a team of researchers from MSK's Sloan Kettering Institute and their collaborators have shown for the first time that fasting can reprogram the metabolism of natural killer cells, helping them to survive in the harsh environment in and around tumors, while also improving their cancer-fighting ability. The study, led by postdoctoral fellow Rebecca Delconte, Ph.D., was published June 14 in Immunity.

Continue Reading.

[arcane-abomination]

There’s lots of Witchcraft within our modern times that can be done online. Especially mobile. Many people have a phone even if they don’t have a computer. This makes carrying a digital grimoire and/or secret craft a lot easier. Yet there are some, that still struggle with finding some good resources. So this post is made for just that.

Keep in mind that everything is meant primarily for phones, since that’s the most common thread among digital Witchcraft.

Free Apps

⚜️ TimePassages: An app for astrology lovers! It has a moon tracker as well as daily horoscope (if you’re into that) but one of the best features is its extensive and detailed birth chart information. It includes a birth chart wheel and all its aspects. It’s a great source for working with planetary energies within and without the self. It’s an all around great app.

⚜️ Rock Identifier - Stone ID: There are several apps that claim to identify stones and Crystals but this is the highest rated and the one I enjoy the most. It not only identifies the stone but can offer a bit of info on some of the beliefs around that stones energy.

⚜️ About Herbs: This is a wonderful app that doesn’t get enough love. It’s an app that discusses medicinal advantages and disadvantages of various plants. They are presented by the Memorial Sloan Kettering cancer center, and provide links to the research to back up their claims. They also make it clear that they are for informational purposes and not to self diagnose, or self medicate without proper treatments from your doctor. They are a wonderful app for those who prefer herbal medicine.

Web Sites

⚜️ Divination:

Tarot: This website sells their decks but also gives free single card draws for all of them. What’s great about it is that while tarot does have basic meanings they all share, the artwork on each deck plays a significant role in each meaning, making the reading far more unique then the average deck

Runes: A fairly simple and easy to use rune generator. They offer several spreads as well as the history behind the practice and meanings on each rune.

⚜️ Sigil Generators: Each website offers a different style to the sigils they create. Each as well has a downloadable feature for those sigils you make.

Sigil Engine

Psychic Science

Sigil Scribe

⚜️ Digital Altars: Digital altars can play an important role for the TechnoPagan. So these are some makers that you can use to make your own.

Picrew

Spells8

Text Symbols

These easily copy and pasted symbols are great for digital spell work and rituals.

⚜️ Gender:♂♀ ⚦ ⚨ ⚩ ⚤ ⚢ ⚣ ⚥ 🜢 ⚲ 

⚜️ Beliefs: ⛤ ⛧ 🜏 ☥ ࿊ ࿋ ࿌ ♱ ॐ ௐ † ☩ ۞

⚜️ Alchemy: 🜁 🜂 🜃 🜄 🜋 🜌 🜔 🜕 🜖 🜗 🜙 🜚 🜛 🜳 🝆 🝊 🝕 🝖 🝘 🝢 🝦 🝩 🝮 🜎 🜍 🜞 🜟 🜣 🜤 🜥 🜦 🜩 🜪 🜻 🜹 🜼 🜾 🝰 🝪 ྿ ☉ ☽

⚜️ Zodiac: ♈︎ ♉︎ ♊︎ ♋︎ ♌︎ ♍︎ ♎︎ ♏︎ ♐︎ ♑︎ ♒︎ ♓︎ 

⚜️ Aspects: ☊ ☋ ☌ ☍ ⚺ ∠ ⚹ □ △ ⚼ ⚻

⚜️ Planets: ☿ ♀ ♁ ♂ ♃ ♄ ♅ ♆ ♇

⚜️ Moons: ⚷ ⚸ ⚳ ⚴ ⚵ ⚶ ☾

⚜️ Stars: ☼ ✬ ✫ ★ ✯ ✧ ✪ ⚝ ✩ ✶ ✷ ✸ ✹ ⁂ ⁑ ✰

⚜️ Runic: ᚠ ᚡ ᚢ ᚣ ᚤ ᚥ ᚦ ᚧ ᚨ ᚩ ᚪ ᚫ ᚬ ᚭ ᚮ ᚯ ᚰ ᚱ ᚲ ᚳ ᚴ ᚵ ᚶ ᚷ ᚸ ᚹ ᚺ ᚻ ᚼ ᚽ ᚾ ᚿ ᛀ ᛁ ᛂ ᛃ ᛄ ᛅ ᛆ ᛇ ᛈ ᛉ ᛊ ᛋ ᛌ ᛍ ᛎ ᛏ ᛐ ᛑ ᛒ ᛓ ᛔ ᛕ ᛖ ᛗ ᛘ ᛙ ᛚ ᛛ ᛜ ᛝ ᛞ ᛟ ᛠ ᛡ ᛢ ᛣ ᛤ ᛥ ᛦ ᛧ ᛨ ᛩ ᛪ ᛫ ᛬ ᛭ ᛮ ᛯ ᛰ

⚜️ Ogham: ᚁ ᚂ ᚃ ᚄ ᚅ ᚆ ᚇ ᚈ ᚉ ᚊ ᚋ ᚌ ᚍ ᚎ ᚏ ᚐ ᚑ ᚒ ᚓ ᚔ ᚕ ᚖ ᚗᚘ ᚙ ᚚ ᚛ ᚜

⚜️ Trigram: ☰ ☱ ☲ ☳ ☴ ☵ ☶ ☷

⚜️ Nature: ❧ ❦ ♣ ♧ ꕥ 𑁍 ❁ ✻ ✽ ❃ ❈ ❊ ✿ ❆ ❅ ✱

⚜️ Geometry: ◆ ◇ ✧ ❖ ✦ ✧ ⬪ ⬫ ░ ▒ ▓ █ ▄ ▌▐ ▀ ■ □ ▢ ▣ ▤ ▥ ▦ ▧ ▨ ▩ ▫ ▬ ▭▮▯▰ ▱ ▲ △ ▴▵▶▸▹►▻▼ ▽▾▿◀◂◃◄ ◅ ◆ ◇ ◈ ◉ ◊ ○ ◌ ◍ ◎ ● ◐ ◑ ◒ ◓ ◔ ◕ ◖◗ ◢ ◣ ◤ ◥ ◦ ◧ ◨ ◩ ◪ ◫ ◬ ◭ ◮ ◯ ◰ ◱ ◲ ◳ ◴ ◵ ◶ ◷ ❍ ❏ ❐ ❑ ❒ ❘ ❙ ❚ ⬒ ⬓ ⬔ ⬕ ⬖ ⬗ ⬘ ⬙ ⬚ ⬝ ⬞ ⬟ ⬠ ⬡ ⬢ ⬣ ⬤ ⬥⬦⬧ ⬨ ⬩ ⬬ ⬭ ⬮ ⬯ ⭓ ⭔

⚜️ Currency: £ € $ ¢ ¥ ƒ ₧ ¤

⚜️ Misc: ♡ ❥ ∞ ♤

[covid-safer-hotties]

Also preserved in our archive

By Andrew Joseph Pegoda, Ph.D.

Unlike its SARS-CoV-1 predecessor a decade prior, SARS-CoV-2—frequently called COVID-19 to lessen alarm—has been an on-going, global crisis starting soon after its emergence in December 2019. The tenth wave of this Level 3 biohazard is starting and the injustices continue.

Official global deaths reported by governments total 7 million. Data scientists, demographers, and economists closely eyeing excess deaths have staggering estimates of actual COVID-19 loses: 20 million by the end of 2021, 30 million by the end of 2023, and currently almost 40 million.

Deaths from this novel, highly contagious virus are sometimes unavoidable. Yet, the vast majority of these seldom-acknowledged deaths are stupid deaths, stupid deaths because they were preventable deaths.

Death tolls from COVID-19 in the United States specifically would be lower had the CDC not given into pressure from Delta Air Lines in 2021 to decrease isolation periods. Death tolls would be lower if states en masse had not rushed to abandon mask requirements in 2021 and 2022. Death tolls would be lower if Hollywood’s stories meaningfully acknowledged COVID-19. Death tolls would be lower if the public narrative had been other than “vax and relax.” Death tolls would be lower if schools and businesses devoted meaningful efforts to improving and monitoring air filtration, especially in elevators. And the recent “back to the office” push will only increase deaths.

Beyond death tolls, I am concerned about what I am naming “stupid (re)infections.”

The typical person in the United States is being reinfected yearly, and the average person has now been infected with COVID-19 more than 3.5 times. And between 20% and 50% of infections are asymptomatic (during the acute phase!).

Repeated infections are unnecessary and avoidable, if mandatory masking in public places had remained and been completely normalized (of course, with appropriate exceptions for those with disabilities that prevent wearing a mask). Hospitals should have never dropped masking requirements, certainly not cancer centers. KN95 and N95 masks are highly effective and easy to wear—a practice that could only increase utility with the corresponding decreased sickness and death. People learned to wash their hands with soap; they can learn to wear a mask.

And this leads me to what I am naming “stupid suffering.”

COVID-19 is not the flu or a cold. Every infection substantially affects the body—including possible cognitive decline and impacts on the heart, T cells, the intestines, and the overall immune system—prompting a growing number of researchers to assert that COVID-19 triggers a new illness that parallels AIDS. Impacts further down the road remain unknown. Still, many people antidotally report having at least some lingering symptoms after their initial symptomatic infection. Specifically, Long COVID, which can be debilitating, impacts tens of millions in the United States, including 6 million children, and currently has no cure. Every infection substantially increases the risk of developing Long COVID. And this stupid suffering disproportionally impacts and further weathering minoritized individuals.

Stupid (re)infections. Stupid suffering. Stupid deaths. We must do better and not allow brute luck to dominate while awaiting treatments and better vaccines.

If missions to save lives and protect best interests are sincere, bioethicists have a profound opportunity, even a categorical imperative, to help lead the way toward a COVID-19 safer future and opportunities for reenvisioned justice, for Aristotle’s the good life.

COVID-19 uniquely shows the heteronomous nature of twenty-first-century life and what little weight negative rights hold as people—especially those already disabled like me—are forced into spaces that ignore the threats.

Andrew Joseph Pegoda, Ph.D., M.A., M.A. (@ajp_PhD), is a Lecturer of Women’s, Gender, and Sexuality Studies at the University of Houston and a Bioethics and Health Policy graduate student at Loyola University Chicago.

[goldheartedsky]

Another day, another round of "Booker should've never been mad at Nicky and Joe amidst his grief!" bullshit that once again centers all this shit on Nicky and Joe when it's not about them.

Grief is a monster. It digs its claws in you in ways that leave unimaginable scars. And losing a child is a *far* different monster than losing family or losing friends. I recently lost my dad and, while the grief was overwhelming, the thought of losing my son is earth shattering. Losing a child upsets the natural order of things and, if you listen to anyone who has lost a child talk about it, it's a pain that never heals. Not after five years. Not after ten years. Not after twenty or thirty.

And Booker had to do it not once, but three times.

And Jean-Pierre, his youngest and last son, dies at 42 years old. The same age Booker was when he suffered his first death. He dies of cancer in a time where there is no treatment, no way to ease his pain. Jean-Pierre dies a horrible, slow death and Booker has to watch it, knowing that his son hates him with every fiber of his body. There is no reconciliation, no forgiveness, no closure.

And that wound inside his soul bleeds. And bleeds. And bleeds. Because there is no way to heal. Grief ebbs as time passes and you're able to try and move on with your life, but when time has stopped at a stand-still for Booker? There is no way to move on.

We can see the complete and utter devastation on Andy's face when Quỳnh is simply mentioned, and this is 300 years after losing her. The pain that Booker is carrying around from the loss of his sons, after a little more of half that time? Unimaginable.

Joe and Nicky got off light. And it's not about them. Because, as Booker correctly pointed out, they had each other.

All he had was his grief.

[mariacallous]

Hours after Russia invaded Ukraine in February 2022, refugees began pouring over the border to Moldova. Ludmila Popovici, the executive director of RCTV Memoria, a Moldovan nonprofit that works with survivors of war and torture, was in Romania at the time undergoing cancer treatment. But with the beginning of what some would now call an “endless war,” Popovici and her team immediately got to work.

They reached out to refugee centers and scoured Facebook groups for those in need of help, including sick children and women experiencing high risk pregnancies. Aided by small donations from partners overseas, they created food packages, delivered medicine, and provided direct cash assistance to the most vulnerable.

“We were all scared that we [Moldova] were going to be the next target for the Russian army,” Popovici explained. “But we knew our help was needed.”

However, more than two years into the war, organizations like Popovici’s are overworked, underfunded, and in many cases, at risk of collapse. Over-reliant on volunteers and facing staff burnout, they are struggling to meet the needs of the women and children they serve.

Every conflict is gendered—whether it’s the nature of conscription or the use of gender-based violence as a weapon of war. But the impact of the war in Ukraine, especially on forcibly displaced persons, has been more gendered than most, largely because of the country’s martial law which prohibits men aged between 18 and 60 from leaving the country.

As a result of this policy, women and children comprise a remarkable 80 percent of the 5.9 million Ukrainian refugees who have left the country since 2022. Many of them have faced gender-based violence, including sexual exploitation, human trafficking, or domestic violence, which has skyrocketed since the war began.

These risks persist today. Our organization, VOICE, has been working with women-led groups across the region since early 2022 to ensure they have access to the resources they need to participate in and lead the humanitarian response. Earlier this year, we conducted a survey of our partners across Ukraine, Poland, Moldova, and Romania, regarding the challenges they were facing and what they were seeing on the ground. They reported high rates of gender-based violence.

Many refugee women and children continue to reside in collective shelters with nonsex-segregated facilities, and limited oversight of who is entering and exiting the buildings. Another key challenge for forcibly displaced women both in Ukraine and abroad is lack of access to financial resources and employment.

In Ukraine, regular shelling has shuttered many schools, businesses, and childcare centers, making it difficult for displaced women to secure employment. Elsewhere in the region, factors such as language barriers, lack of childcare, and an absence of clear information about refugees’ right to work have made it hard to achieve a decent standard of living and put Ukrainian women at risk of exploitation.

For many Ukrainian women, who are grappling with the impacts of trauma and displacement, the war has only exacerbated low access to health care. All this is happening against the backdrop of a broader crackdown in the region, which has seen abortion rights rolled back in countries like Poland, Hungary, and Romania; direct budget cuts to organizations serving domestic violence survivors; a weakening of institutions advocating for gender equality; and an elevated risk of violence for LGBTQI+ people.

In the wake of Russia’s invasion of Ukraine, women-led organizations like RCTV Memoria in Moldova, Martynka Foundation in Poland, and NGO Fulcrum in Ukraine have mobilized rapidly across the region. In our survey, 78 percent of respondents reported that they have expanded their teams and operations, all while continuing to fulfill their original missions.

Like Popovici, they did this both because the situation required it, and because their expertise and credibility allowed them to take action swiftly while understanding cultural nuances in ways that larger, international nongovernmental organizations (INGOs) and U.N. agencies could not. But they have done so without consistent resources and financial support, often forced to draw upon their own reserves or volunteer labor in order to deliver their services.

In 2022, Ukraine received almost $30 billion in humanitarian funding. However, less than 1 percent of that made its way to local women’s rights organizations, movements, and institutions, according to a report by the Institute for Journalism and Social Change (IJSC).

Organizations cite onerous funding requirements and red tape delays including heavy paperwork and narrow application windows (One large INGO, for example, required applicants to submit no less than 30 items for accountability checks.) Many organizations simply struggle to find the time to apply for funding opportunities while simultaneously meeting the needs of their communities. Often, they feel they are not trusted by mainstream funders like U.N. agencies and INGOs—not viewed as having the right accountability systems, or perceived as being too political for their public support for reproductive rights and LGBTQI+ rights.

These challenges are not unique to Ukraine. They play out in conflicts around the world—from Afghanistan to Sudan. As the IJSC report details, only about 2 percent of all humanitarian funding goes to local NGOs and civil society organizations based in the developing countries aid is being delivered to. The proportion of that funding that goes to organizations led by women and girls is even smaller. Only 12 percent of the leaders that responded to our survey reported that their organization has sufficient funding to operate and implement their planned work in 2024.

“Our biggest concern is that by the end of 2024, there will be no Ukrainian-led organizations providing GBV services in Ukraine,” said Nastya Podorozhnya, founder of Martynka Foundation, a Polish-Ukrainian NGO that supports victims of human trafficking, war, rape, and domestic violence.

Almost three-fourths of the organizations we surveyed reported that if the resources were available, they would further expand their services for survivors of gender-based violence. As one Moldovan respondent explained, “Often, the lack of resources prevents us from effectively addressing [gender-based violence]. Even when resources do become available, they may come too late, rendering the problem obsolete or causing survivors to withdraw, lose hope, and cease engaging in dialogue.”

Even by the U.N.’s own measures, response to gender-based violence remains underfunded. But it did not have to be this way. Unlike in typically new conflict or disaster settings, the U.N. had fostered strong relationships with local Ukrainian organizations which have dealt with the threat of a Russian invasion since 2014. Similarly, though Ukraine’s neighbors had not previously seen a large U.N. presence, they had fostered a dynamic women’s sector.

Together, this meant that the international community had a unique chance to innovate and reimagine the way it engaged with local stakeholders. They should have prioritized engaging with local women’s movements and networks and encouraged their active participation in decision making processes. Based on the information provided by the women’s rights organizations we surveyed, however, this chance has largely gone unseized.

Despite pledges toward localization, women-led organizations continue to find themselves on the outside looking in. The initial phase of the war may have ended, but the crisis it triggered has not. Ukraine continues to fight back against Russia’s assaults with insufficient international support. Millions of Ukrainians continue to be displaced across the region, struggling to meet their basic needs in the face of ongoing trauma and loss. The question of what happens after the war is over continues to loom over Ukrainians.

Popovici’s organization, RCTV Memoria, worked with over 300 survivors each year before Russia invaded. In 2023 that effort increased by tenfold, and the organization was working with over 3,000 Ukrainian refugees alone. To do this, they have had to work essentially nonstop, serving survivors during the day and doing administrative work at night, mobilizing volunteers, and working without vacations or weekends.

RCTV Memoria has increasingly transitioned its activities with Ukrainian refugees to not just providing essential services to the vulnerable, but also to providing the psychosocial and economic support that displaced Ukrainians will need when they return home. “They are the most precious resource of Ukraine and they are in a safe place here,” Popovici said. “They will have to mobilize themselves to be ready to go back home and contribute to the reconstruction of their country.”

More than two years into this conflict, it is time the world started approaching it as the crisis that it is. This means giving the organizations that are working on the frontline the sustained, flexible, and long-term funding they need to increase their capacity and meet the needs of the populations they serve, instead of forcing them to compete for scraps and keeping them in a perpetual state of uncertainty.

Organizations like Popovici’s were there before the war, and they will be thereafter. They have proven they understand the needs and aspirations of the constituencies they serve, and that they have the skills and expertise to meet those needs. It is time the international community gave them the respect—and the funding—they deserve.

[cancerhealingretreats]

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[seresinsbabe]

Conveniently Yours

Pairing: Jake Seresin x fem!reader

Synopsis: In a desperate attempt to pay for your mom's cancer treatment you take a job as a dancer at one of NYC's prestigious strip clubs where you meet Jake Seresin who just happens to need a wife.

Warnings: 18+ MINORS DNI, mild smut, oral (fem receiving), arguing, allusions to sex.

Word Count: 1.9k

Prev Chapter | Masterlist | Next Chapter

More weeks passed, closer and closer to the wedding. You were thankful you’d both decided on a small affair. At this point you knew you really couldn’t handle a big to do. Especially when Jake had stayed just as cold as ever. There’d been a few times you’d seen him warm up. You weren’t sure if it was really him opening up or if it was because Rooster was there so often.

Not that you hated Rooster being over. Honestly his presence made you feel much less awkward in the home as he always managed to fill it with happy noise. It was clear Bradley was a frequent flier in the penthouse. A testament to how close of a relationship the two men had. You’d caught glimpses of who Jake was when it was just him and his closest friend. He was similar to the Jake you met at the club. The one that had been with you for only a few weeks before he’d turned cold.

“Hey chipmunk, come to join us? Longhorns are up.” Bradley had taken to calling you chipmunk when he came over one day and found you with your cheeks so stuffed full marshmallows. It had been your time of the month and marshmallows were this past period's comfort food. Your eyes darted to Jake who didn’t even seem to bother looking at you. He was more focused on the game. Both men were wearing jeans, something Jake didn’t wear often, and those ugly orange jersey’s.

You scrunched your face up in disgust. “Enjoy the wins now boys, the Sooners are comin’ for ya.” That seemed to grab Jake’s attention. You hadn’t let it be known you were a Sooner fan. He almost looked betrayed and he opened his mouth to say something but his phone rang. Whoever it was must have been important enough to drag him away from the game. Then again, sometimes you were convinced he would take any excuse to get away from you in private.

This was a fake marriage, yeah, but that didn’t mean it wasn’t painful seeing him avoid you. Especially when he put on such a good show in front of the public. Just the day before he’d kept his arm wrapped tightly around your waist, placing soft kisses on your forehead and temples while you were at a promotion event. Big crowds filled with paparazzi and girls screaming for Jake’s attention still weren't something you were used to being in the center of. And Jake knew that. He was so comforting during public appearances that it made digesting his cold demeanor at home that much harder.

What Jake hadn’t told you, or anyone, was that he was trying to distance himself from you. Those first few weeks, where he’d been sweet and you’d spent time getting to know one another, had a stronger effect on him than he was willing to admit. He wasn’t ready to give up his bachelor lifestyle yet, or at least that’s what he thought. And the way you’d softly sing when focusing on anything had his stomach doing flips. So did your laugh, your smile, everything about you. What had really done him in was when he came home from a really shitty day and you had his favorite take out, Thai food, and his favorite beer ready for him. He’d come so close to crossing a line that night he knew he had to distance himself.

Maybe he was going about it the wrong way with the women and the coldness. He had no idea if you felt the same things he was. It was likely just in your nature to be so kind and thoughtful. Which only meant he had to distance himself even more to keep himself from getting hurt. He’d been burned before and he wasn’t going to let that happen.

Course he hadn’t expected Bradley to find interest in you. Then again you were beautiful. You weren’t fake like most of the women that chased after them. Bradley would be an idiot not to find interest in you. And as much as Jake was starting to realize he didn’t like Bradley flirting with you he knew he couldn’t stop it. As long as it was in private where no one would see and sun a story on it, he had no grounds to stop either of you. Not unless he wanted to admit he was feeling things he hadn’t felt in a very long time. Didn’t make it any easier that you seemed to flirt right back with Bradley.

Of course Jake didn’t know it had gone further than just flirting. You hadn’t fucked Bradley…not yet. There had been some heavy petting, but you’d yet to go further than that. The first makeout happened when the boys were drinking. Jake had called over one of his frequent fliers. Leaving you and Bradley on the couch. One thing led to another and you were perched in his lap, tongues intertwined and hands groping anywhere and everywhere. Since then it had only continued.

What Bradley wanted you weren’t sure. It seemed purely physical and that you were okay with. There was no way you’d be able to balance keeping a real relationship secret while faking a whole marriage to his best friend. Even then, with everything going on with your mom you didn’t know that you really wanted a relationship. It just all seemed like too much. Sex was easy. Sex was transactional. No feelings required, just hormones.

You weren’t even paying attention to Bradley. Looking at something in your phone when his lips were on your neck. The device was immediately dropped, falling between the cushions of the couch as you moved your body, opening yourself up to him. Jake’s voice could be heard down the hall. His footsteps sounded closer and then farther. He was pacing.

“Wan’taste you.” The idea of Rooster’s mouth on you sent shocks straight to your cunt. You rolled her hips, brushing your core against the bulge in his jeans.

“Please.” You whimpered, your body begging to be touched in a way it hadn’t for some time “Bradley,” you half whispered half moaned as he nipped at your collar bone. “Bathroom.” It was the closest room he’d be able to get you to. You tapped his shoulder and he grunted against your skin, but lifted you up nonetheless. His mouth never leaving your skin.

In the bathroom he set you on the counter, stepping between your legs. He lifted you up, pushing the shorts you had on down, finding you had nothing on under them, then set you back down. Sinking down to his knees as you gripped the edges of the counter in anticipation.

Bradley’s curls brushing along your skin as he peppered kisses and nips up your thighs. When he reached your center he ran his nose up your slit, pulling away to look up at you with lust filled eyes. Your wetness shining on the tip of his nose. “All that for me, chipmunk?” You nodded, earning a grin and then a fat lick up your slit.

The moan you let out encouraged him and he licked again. Your fingers found their way into his curls and you tugged. A silent ask for more. Thankfully Bradley knew this had to be quick. No telling how long Jake’s phone call would last.

His lips wrapped around your clit, one finger sliding into your hole. You had to clamp your free hand over your mouth to muffle the moan it drew from you. Another finger slid in and then he was really working you over. The moans were starting to get hard to contain. Even more so when his fingers started purposefully brushing along the spongy spot in your cunt.

“Fuck!” You mewled, rolling your hips harder against his face. “I’m gonn-” you cried out loudly but hit down on your lip to shut yourself up. Only allowing whimpers through as you came on his fingers and face.

Bradley came up and kissed you, letting you taste yourself. You went to undo his jeans to return the favor but he stopped you. “Another time, this was all about you Chipmunk.” He pecked your lips and then helped you down from the counter. Neither of you were prepared for the sight that was behind the door.

Jake’s phone call had ended shortly after you and Brad disappeared. He came back, looking confused until he heard the moans from the bathroom. He’d spent the next several minutes with his ear pressed to the door hearing you make sinful sounds while his best friend ate you out. If it weren’t for the fact it was someone other than yourself or him drawing those sounds out of you he would have found himself hard. Instead he was just beyond pissed.

“My wife? Are you fucking kidding me Rooster!” Jake’s face started turning red.

“She’s not yet your wife and even if she was it’s a fake fucking marriage dude! So I gave her some attention. It’s not like you do!” Oh god. You could feel your own face heating up out of embarrassment.

Jake rolled his eyes and walked away, giving the both of you room to step out of the bathroom.

“Doesn’t matter, it shouldn’t be happening at all.”

Now it was your turn to get pissed off. “Are you fucking kidding me? You can have woman after woman over, hell I’ve seen you bring two at a time, but I can’t do the same? How is that fucking fair! I thought this was just business?” You’d never raised your voice or gotten mad really. So hearing you talk like this was new for both of the men.

“It is business!”

“Then I can fuck who I want so long as I don’t let the public or anyone else see, right?” Jake kept quiet. Because you were right. It wasn’t fair for him to fuck other women. And he knew he couldn’t let himself have you like that. It was too dangerous for him. So instead of saying anything he just turned around and stormed off to his room. He didn’t know who he was more upset with — himself or you.

You let out a sigh and turned to Bradley, an apologetic look on your face.

“Don’t worry about it, not the first time we’ve fought over a girl.” Brad chuckled, placing a kiss on the top of your head. It was soft and comforting and had you wrapping your arms around him.

You didn’t understand why Jake was being like this. Why was he pissed that you were doing the same things he was? Maybe it was the fact that it was his best friend. That was the only thing that made sense, but even then it shouldn’t matter if all Jake saw you as was a business partner and nothing more.

“In the spirit of pissing him off more, want to stay? I’ve got half a bed going unused?” Brad let out a laugh but nodded.

“I always did enjoy pissing the bastard off.” He grinned and tossed you over his shoulder, causing you to squeal and let out a laugh. One that Jake could hear from his room.

That was the first time Jake didn’t invite a woman over. He didn’t come out of his room. Just laid there the tv playing as an attempt to block out any noises coming from your room. The last sound he wanted to fall asleep to was that of his best friend fucking you.

@love2write2626 @cherrycola27 @chaoticversion @3in1shampooconditionerbodywash @alldaysdreamers @sexytholland @mishala005 @a-serene-place-to-be @emma8895eb @aemondssiut @averyhotchner @blairfox04 @realdirectionx @rintheemolion @xoxabs88xox @clancycucumber230 @inky-sun @ilovewhalesharks444 @gigisimsonmars @imnotcreativeenoughforthisblog @bl6o6dy @potato-girl99981 @emorychase @hangmandruigandmav @boltgirl426 @misshoneypaper @starkleila

[pansydivided]

always makes me so upset that the concern about treating PCOS is always centered around how it makes people look less masculine, as if thats the main problem with PCOS. ive talked to trans men with PCOS (or suspect they have it) who are like "i don't need to treat it because it just gives me extra testosterone! i like looking manly" and its always so concerning because PCOS does have actual physical health concerns! even if you don't want to take estrogen as a treatment you still need to be seeing a gynecologist regularly, getting tested for insulin resistance (very very common with PCOS and can lead to diabetes if untreated) and making sure you're aware of your cancer risks and getting checked regularly (yes you will need to get a pap smear probably im sorry its better then cancer 😔 they're changing the recommendation from 21 to 25 so i can avoid it a little longer haha). not ovulating naturally (without birth control i mean) is considered a risk factor for uterine cancer, i know having a period sucks but you need to be doing it safely, if your body stops having periods without medication its not safe. its so infuriating that people's biggest concern about PCOS always seems to be "fat and hairy" and not heart disease risk, diabetes risk, insulin resistance, cancer risk and even just having cysts in your ovaries that can cause health issues if they get too big.

[a-room-of-my-own]

The FDA hasn’t approved them for gender dysphoria, and their effects are serious and permanent.

The fashion for transgenderism has brought with it a new euphemism: “gender-affirming care,” which means surgical and pharmacological interventions designed to make the body look and feel more like that of the opposite sex. Gender-affirming care for children involves the use of “puberty blockers”: one of five powerful synthetic drugs that block the natural production of sex hormones.

The Food and Drug Administration has approved those medications to treat prostate cancer, endometriosis, certain types of infertility and a rare childhood disease caused by a genetic mutation. But it has never approved them for gender dysphoria, the clinical term for the belief that one’s body is the wrong sex.

Thus the drugs, led by AbbVie’s Lupron, are prescribed to minors “off label.” (They are also used off-label for chemical castration of repeat sex offenders.) Off-label dispensing is legal; some half of all prescriptions in the U.S. are for off-label uses. But off-label use circumvents the FDA’s authority to examine drug safety and efficacy, especially when the patients are children. Some U.S. states have eliminated the need for parental consent for teens as young as 15 to start puberty blockers.

Proponents of puberty blockers contend there is little downside. The Department of Health and Human Services claims puberty blockers are “reversible.” It omits the evidence that “by impeding the usual process of sexual orientation and gender identity development,” these drugs “effectively ‘lock in’ children and young people to a treatment pathway,” according to a report by Britain’s National Health Service, which cites studies finding that 96% to 98% of minors prescribed puberty blockers proceed to cross-sex hormones.

Gender advocates also falsely contend that puberty blockers for children and teens have been “used safely since the late 1980s,” as a recent Scientific American article put it. That ignores substantial evidence of harmful long-term side effects.

The Center for Investigative Reporting revealed in 2017 that the FDA had received more than 10,000 adverse event reports from women who were given Lupron off-label as children to help them grow taller. They reported thinning and brittle bones, teeth that shed enamel or cracked, degenerative spinal disks, painful joints, radical mood swings, seizures, migraines and suicidal thoughts. Some developed fibromyalgia. There were reports of fertility problems and cognitive issues.

The FDA in 2016 ordered AbbVie to add a warning that children on Lupron might develop new or intensified psychiatric problems. Transgender children are at least three times as likely as the general population to have anxiety, depression and neurodevelopmental disorders. Last year, the FDA added another warning for children about the risk of brain swelling and vision loss.

The lack of research demonstrating that benefits outweigh the risks has resulted in some noteworthy pushback in the U.S. and abroad. Republican legislatures in a dozen states have curtailed or banned gender-affirming care for minors. Finland, citing concerns about side effects, in 2020 cut back puberty blockers and cross-sex hormones to minors. Sweden followed suit in 2022 and Norway this year. Britain’s National Health Service shuttered the country’s largest youth gender clinic after 35 clinicians resigned over three years, complaining they were pressured to overdiagnose gay, mentally ill, and autistic teens and prescribe medications that made their conditions worse.

Still, the U.S. and most European countries embrace a standard of care that pushes youngsters toward “gender-affirming” treatments. It circumvents “watchful waiting” and talk therapy and diagnoses many children as gender dysphoric when they may simply be going through a phase.

Gender-affirming care for children is undoubtedly a flashpoint in America’s culture wars. It is also a human experiment on children and teens, the most vulnerable patients. Ignoring the long-term dangers posed by unrestricted off-label dispensing of powerful puberty blockers and cross-sex hormones, combined with the large overdiagnosis of minors as gender dysphoric, borders on child abuse.

[eretzyisrael]

Good News From Israel

In the 20th Sep 23 edition of Israel’s good news, the highlights include:

Israeli AI system identifies thousands of new effective combination cancer therapies.

Two examples of Israel’s inclusive army.

Israelis are helping survivors of the earthquake in Morocco.

More Israeli breakthroughs to prevent global hunger.

Israel is “on the global map” for trade links, electricity, and (we hope) peace.

Israeli innovations will protect the vulnerable in Oklahoma and Japan.

The “People of the Book” has a new National library.

Muslims and Jews pray together at the Western Wall in Jerusalem.

Read More: Good News From Israel

The Jewish New Year is a very appropriate time to celebrate more new exciting Israeli life-changing innovations and activities. These include new ways to combine cancer treatments to increase effectiveness with less side-effects. And a new Israeli treatment for MS is now available on-line. The US FDA have approved new Israeli software to guide cancer surgery and a new Israeli ultrasound-guided device to take biopsies. Meanwhile, Europe is funding trials of a new Israeli formula for feeding premature newborns. There's a new sign-language tour of Jerusalem's Tower of David; a new home for lone soldiers; the first visit to Israel by the UK's latest Foreign Minister; and the first official Israeli delegation to a conference in Saudi Arabia. Israelis have found new ways to communicate with plants; new ways to extract milk proteins from mushrooms and to generate new proteins using biotechnology; new ways to motivate children at school; and new protective fireproof uniforms. Recent diplomatic announcements opens up the prospect of a new age where Israel provides natural gas and electricity to Europe and becomes the center of a new trade route linking Europe, the Middle East and India. Meanwhile, numerous new business ventures have just been launched by Israeli startups. Jerusalem, the eternal city, continues to be renewed as the rebuilt Tiferet synagogue nears completion. Finally, visitors to the Kotel (Western Wall) had a new experience - the sight of Jews and Muslims praying together. It brings new hope for the New Year. The photo (TY Sharon) is of the inside of Jerusalem's new National Library of Israel, which will be opening in October.  Wishing those that celebrate it a peaceful and meaningful Yom Kippur and a very happy Sukkot / Tabernacles

[churchofgladtidingsyubacity]

ANGIE GOFUNDME

I received one of the saddest calls ever early this morning! I answered the phone to find my sweet sister saying our beloved niece Angie went to heaven!

Every once in a while, life presents us with battles that are too monumental to face alone. Right now, Angie is in the midst of one such battle with Brain Cancer, and she needs our faithful support.

Angie Talbot is in the heart of our Church community. She is a symbol of strength and resilience. She is a talented 35 year old young adult who is completely dedicated to the LORD.

Just a few months ago, Angie's world turned upside down. On June 25th, she was diagnosed with cancerous anaplastic oligodendroglioma in her brain. The days that followed saw Angie bravely undergo a series of surgeries: first, to remove the large tumor on June 29th, then to address a serious brain infection on July 21st, followed by the surgical insertion of a mesh titanium plate on July 2

8th. By September 4th, a drainage shunt became essential for her well-being.

4 serious brain surgeries in a matter of 5 weeks!! Angie's journey and fighting spirit doesn’t end there. She's now gearing up for her fifth treatment, in this short period of time. This one a natural treatment at a specialized center in Idaho, starting mid October. This promises a ray of hope but comes with a hefty price tag of $30,000-$35,000.

As Angie bravely faces these medical challenges, her parents, Duane and Juanita along with the entire Glad Tidings Church Community are with her every step of the way. Together, they are all determined pray for her and fight spiritually. This treatment is to rebuild Angie’s body fortifying her to wage and win this battle against cancer!

This is not something anyone should ever have to go through alone!!

This is our call to action. Let's bathe them in our love, prayers, and generosity in their hour of need. Let’s remind them that in this vast world, they aren't alone – they have a community of friends, loved ones, and kind-hearted strangers ready to lend a helping hand.

It's more than just financial support; it's a testament to the strength and unity of our community. Together, we can help Angie rebuild, recover, and fulfill her destiny!!

"Love your neighbor as thyself." Now is our chance to flood Angie, Duane, and Juanita with prayers, love, and the much-needed financial support to cover the treatment costs.

Every contribution, no matter how small, moves us a step closer to giving Angie the future she deserves. Let’s be the beacon of hope in her journey.

God Bless!

Pastors Dave and Cheryl Bryan

Church Of Glad Tidings

https://www.gofundme.com/f/ANGIE-passed---ANGIE-fight-against-brain-cancer

[jcmarchi]

Innovative Chemotherapy Approach Shows Promise Against Lung Cancer - Technology Org

New Post has been published on https://thedigitalinsider.com/innovative-chemotherapy-approach-shows-promise-against-lung-cancer-technology-org/

Innovative Chemotherapy Approach Shows Promise Against Lung Cancer - Technology Org

Lung cancer is not the most common form of cancer, but it is by far the deadliest.

Kytai T. Nguyen, the Alfred R. and Janet H. Potvin Distinguished Professor in Bioengineering at UTA. Image credit: UTA

Despite treatments such as surgery, radiation therapy and chemotherapy, only about a quarter of all people with the disease will live more than five years after diagnosis, and lung cancer kills more than 1.8 million people worldwide each year, according to the World Health Organization.

To improve the odds for patients with lung cancer, researchers from The University of Texas at Arlington and UT Southwestern Medical Center have pioneered a novel approach to deliver cancer-killing drugs directly into cancer cells.

“Our method uses the patient’s own cellular material as a trojan horse to transport a targeted drug payload directly to the lung cancer cells,” said Kytai T. Nguyen, lead author of a new study on the technique in the peer-reviewed Bioactive Materials and the Alfred R. and Janet H. Potvin Distinguished Professor in Bioengineering at UTA. “The process involves isolating T-cells (a type of immune cell) from the cancer patient and modifying them to express a specific receptor that targets the cancer cells.”

The crucial step in this new technique involves isolating the cell membrane from these modified T-cells, loading the membranes with chemotherapy medications, and then coating them onto tiny drug-delivery granules. These nanoparticles are roughly 1/100 the size of a strand of hair.

Jon Weidanz, associate vice president for research and innovation and professor of kinesiology and bioengineering. Image credit: UTA

When these membrane-coated nanoparticles are injected back into the patient, the cell membrane acts as a guide, directing the nanoparticles to the tumor cells with precision. This approach is designed to deceive the patient’s immune system, as the coated nanoparticles mimic the properties of immune cells, avoiding detection and clearance by the body.

“The key advantage of this method lies in its highly targeted nature, which allows it to overcome the limitations of conventional chemotherapy that often lead to detrimental side effects and reduced quality of life for patients,” said co-author Jon Weidanz, associate vice president for research and innovation and a researcher in kinesiology and bioengineering.

“By delivering chemotherapy directly to the tumor cells, the system aims to minimize collateral damage to healthy tissues,” continued Weidanz, who also is a member of UTA’s Multi-Interprofessional Center for Health Informatics.

In the study, researchers loaded the nanoparticles with the anti-cancer drug Cisplatin. The membrane-coated nanoparticles accumulated in parts of the body with the tumors rather than in other parts of the body. As a result, this targeted delivery system reduced the size of the tumors in the control group, demonstrating its efficacy.

“This personalized approach could pave the way for a new era of medicine tailored to each patient’s unique characteristics and the specific nature of their tumor,” Nguyen said. “The potential for reduced side effects and improved effectiveness makes our technique a noteworthy advancement in the field of cancer treatment.”

Source: University of Texas at Arlington

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