#medical type

[thepinkheaded-doctor202]

[uniquegalaxyfox]

[reasonsforhope]

A new treatment combining ReCET and semaglutide could eliminate the need for insulin in type 2 diabetes, with 86% of participants in a study no longer requiring insulin therapy. The treatment was safe and well-tolerated, and further trials are planned to confirm these results.

Groundbreaking research presented at UEG Week 2024 introduces a promising new treatment approach for type 2 diabetes (T2D) that has the potential to greatly reduce or even eliminate the need for insulin therapy.

This innovative approach, which combines a novel procedure known as ReCET (Re-Cellularization via Electroporation Therapy) with semaglutide, resulted in the elimination of insulin therapy for 86% of patients.

Globally, T2D affects 422 million people... While insulin therapy is commonly used to manage blood sugar levels in T2D patients, it can result in side effects... and further complicate diabetes management. [Note: Also very importantly it's fucking bankrupting people who need it!!] A need therefore exists for alternative treatment strategies.

Study Design and Outcomes

The first-in-human study included 14 participants aged 28 to 75 years, with body mass indices ranging from 24 to 40 kg/m². Each participant underwent the ReCET procedure under deep sedation, a treatment intended to improve the body’s sensitivity to its own insulin. Following the procedure, participants adhered to a two-week isocaloric liquid diet, after which semaglutide was gradually titrated up to 1mg/week.

Remarkably, at the 6- and 12-month follow-up, 86% of participants (12 out of 14) no longer required insulin therapy, and this success continued through the 24-month follow-up. In these cases, all patients maintained glycaemic control, with HbA1c levels remaining below 7.5%.

Tolerability and Safety

The maximum dose of semaglutide was well-tolerated by 93% of participants, one individual could not increase to the maximum dose due to nausea. All patients successfully completed the ReCET procedure, and no serious adverse effects were reported.

Dr Celine Busch, lead author of the study, commented, “These findings are very encouraging, suggesting that ReCET is a safe and feasible procedure that, when combined with semaglutide, can effectively eliminate the need for insulin therapy.”

“Unlike drug therapy, which requires daily medication adherence, ReCET is compliance-free [meaning: you don't have to take it every day], addressing the critical issue of ongoing patient adherence in the management of T2D. In addition, the treatment is disease-modifying: it improves the patient’s sensitivity to their own (endogenous) insulin, tackling the root cause of the disease, as opposed to currently available drug therapies, that are at best disease-controlling.”

Looking ahead, the researchers plan to conduct larger randomized controlled trials to further validate these findings. Dr. Busch added, “We are currently conducting the EMINENT-2 trial with the same inclusion and exclusion criteria and administration of semaglutide, but with either a sham procedure or ReCET. This study will also include mechanistic assessments to evaluate the underlying mechanism of ReCET.”

-via SciTechDaily, October 17, 2024

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Note: If it works even half as well as suggested, this could free so many people from the burden of the ongoing ridiculous cost of insulin. Pharma companies that make insulin can go choke (hopefully).

[saturnsocoolioyep]

In the same vein as "I've been taking my medication for long enough that I haven't experienced any symptoms in a while, I must not need to take it anymore! (Spoiler alert: the meds are why you haven't had symptoms)" I present to you a similarly clownish thought process- "I haven't experienced that trigger in a long time, maybe I was just exaggerating how bad it was and it'll be fine to engage with this! (Spoiler alert: take a fucking guess babes)"

[creekfiend]

listen i've had to read a hundred other posts with hyperbole and metaphor today and i'm not in the fucking mood

I'll have my butler show you the door

[starrysharks]

🤒🩷💙💉

close ups:

+ inspo (literally my fav miku fig ever):

[boimann]

Shoutout to smart videogame men with dark hair and glasses,

I am and forever will be a slut for you <3

[juvian]

“It eats dust in the atmosphere. The composition of the dust determines the color of its core.”

Do not repost!

[nibbelraz]

ive been thinking about the 'mqf finds out sqh is god' thing you said and honestly. i think the best way for it to happen is that someone completely random tells him like 'maybe you should ask sqh for a cure seeing as he made the plant to begin with'. everyone who knew kinda assumed he already did too. this is news to him. tf you mean the most pathetic little meow meow of a martial brother is god. horror violin chord. sqh is already running. adios compadre he knows that the difference between medicine and poison is the dose and believe you him he would make another cure if he could but even 'gods' gotta eat mu-shidi!!!

I AGREE Actually think everyone at An Ding Peak knows very well Shang Qinghua is a God either that he told them or they just worked with him long enough that they went "Hey he DEFINITELY isn't normal" which then spread around towards everyone else and somehow left poor Mu Qingfang out of the loop.

He's unfortunately god, and I don't blame him for what he's going to do to Shang Qinghua once he finds out.

[sierraveree-art]

[tavina-writes]

I started writing yet another tag essay in the notes of a different post where OP posited that the reason established relationships that are rock solid or functional are hard to write and find in fiction because there's missing tension due to the lack of will they won't they, and how one way to solve this in a story is to make the characters insane about each other. (The post is here.)

And don't get me wrong! I like when characters are a little or a lot unhinged about each other! and I also like relationships that self destruct, tragedies that end badly, and all that jazz I enjoy these things a lot! They're good things!

But I'm thinking about relationship tension again and how like, okay yes sometimes we want our characters confess they're in love with each other and get together and sail off into a soft epilogue, etc. This too is love!

But I think fundamentally to deny the fact that two (or more) people can love each other deeply, be totally committed to each other, and yet still have difficulties and life problems to tackle together is an underexplored facet of romance. The mundane of this is where the real romance lies on our day to day as people, and I find this so...rarely? tackled in fiction?

Maybe this is because I'm ace, but I feel that there's a distinct? vibe to these sorts of mature and enduring romances where like, the love is there, the commitment is there, but we still have moments we need to work for it because that's life and we work for it because we find each other worth it.

What is more romantic than compromise with someone you care for deeply? What is more romantic than tackling problems together and trying to come to an agreement and sometimes not being able to but still having done your best and accepted the outcome anyway?

What is a long lasting relationship that isn't about give and take and growing together or coming apart? Aren't those stories interesting? How could any long lasting relationship where people are deeply in love with each other be boring when like, to BE in a relationship with someone for ten, twenty, thirty, sixty years and come out the other side of that saying 'you're the one, you're still the one, you've always been the one' is one of the most wild and rare type of relationships to have?

What sort of sacrifice and compromise and work it takes to build that sort of relationship, isn't that interesting? To persist despite moments of doubt and periods of despair and all the work it takes in mundanity? all the trials a relationship like that has to survive and has survived, isn't that still tension? isn't that still interesting?

Maybe it's just me that I find this more interesting than "will they? won't they?" Either they will or they won't but when I'm reading a romance they mostly will! But do they have what it takes to stay there? And if they do isn't that one of the most interesting things in the world to look at?

Isn't that also love?

[uniquegalaxyfox]

[reasonsforhope]

"A 25-year-old woman in China is the first person worldwide to have type 1 diabetes reversed through stem cell therapy.

The therapy used the patient’s own cells to create personalized stem cells, which were then used to grow fresh insulin-producing islets.

This breakthrough offers hope for millions with diabetes, potentially eliminating the need for daily insulin injections and reducing complications.

In a groundbreaking medical achievement, a 25-year-old woman in Tianjin, China, has had her type 1 diabetes reversed through a novel stem cell therapy. This marks the first time such a feat has been accomplished globally, offering new hope for millions living with the chronic condition.

The patient, who had been struggling with type 1 diabetes, underwent a pioneering treatment that involved converting her own cells into personalized stem cells. These stem cells were then used to grow fresh clusters of ‘islets,’ the hormone-producing cells in the pancreas responsible for regulating blood sugar levels.

As Nature reports, this therapy’s unique approach of transplanting the newly created islets into the patient’s upper abdomen near her pancreas sets it apart from previous islet transplant methods. This strategic placement allows for easier monitoring via MRI, a significant advantage over traditional liver transplants.

“I can eat sugar now,” the woman said on a call with Nature. After over a year since the transplant, she says, “I enjoy eating everything — especially hotpot.” The woman asked to remain anonymous for privacy reasons.

Experts are astonished at the results, according to Timesnownews. “They’ve completely reversed diabetes in the patient, who was requiring substantial amounts of insulin beforehand,” said Dr. James Shapiro, a transplant surgeon and researcher at the University of Alberta in Edmonton, Canada.

The implications of this breakthrough are far-reaching, as it could potentially revolutionize the way we treat diabetes. By using a patient’s own cells to create personalized stem cells, this therapy bypasses the limitations of donor islet shortages and the need for immunosuppressive drugs, which have hindered the success of conventional transplant methods.

‘If this is applicable to other patients, it’s going to be wonderful,’ diabetes researcher Daisuke Yabe of Japan’s Kyoto University told reporters via Daily Mail.

As the world watches closely, the success of this case sparks hope for the millions of individuals living with type 1 diabetes. It represents a significant step forward in regenerative medicine and paves the way for further research and development in the field."

-via Gadget Review, September 30, 2024

[kathrynmhahn]

TOP 10 IMDB RATED ER EPISODES | Part 1

[virtualgirladv]

how do i figure out blood types at home and do minor blood transfusions? not like time critical or anything but i need to know for normal reasons please help you can trust me im not being weird i just have to do a thing its like really important and i dont want ask doctors or blood testing people things cause yeah ya know so please?

[s0fter-sin]

fainting goat hybrid!ghost whose father and brother loved to scare him and make him faint; exploiting a weakness he didn’t understand and didn’t know how to stop. they took sadistic pleasure in watching his body lock up and fall to the ground with no hope of catching himself until he ended up with more bruises and scrapes from falling than from being beaten

that helplessness chafed at him and he forced himself through the drawbacks of his biology to secure a place in the military, even with the prejudice against prey animals. just for him to take a mission in mexico and find himself enduring the “hospitality” of roba who thinks his involuntary paralysis is a great deal of fun; especially when he learns he’s conscious the whole time

what haunts ghost most is his waking autopsy

not the pain of the incisions, not the trauma of watching roba reach into his body and play with his insides, but the knowledge that he couldn't get away because his own body betrayed him. he wasn't put under, no drugs coursed through his system. he didn’t have restraints fitted on him to lock him to the operating table. it wasn’t necessary

roba just had to make him faint first

after digging himself out of his grave, ghost puts himself on a dangerous cocktail of muscle relaxers and other medications; hormones that block hybrid instincts, vasodilators to increase blood flow and stop his muscles locking up, anti-anxiety meds to cut off his surprise response at the root. he puts his body through the wringer to the point that medical is constantly worried for his health and shocked that he isn't regularly OD’ing

but he will never let his body betray him again