#jw myers

[josephwoll]

goalie hugs after woll's win over the bruins!!

(📷: Kevin Sousa/NHLI via Getty Images)

[doorsangel]

I just wanna touch somebody So they can be their own somebody Breathe air in their lungs Tell them they're enough

[dirtylowdown2]

Junior Wells Hoodooman Blues

"JUNIOR WELLS (Amos Blakemore, December 9, 1934, Memphis TN). Arrived Chicago ('50), ran with Blackstone Rangers street gang; soon formed The Aces (w/Louis & Dave Myers, Fred Below), then replaced Little Walter on harp in Muddy Waters band ('52). First rec. as leader in '53 for States; long run of singles for Chief/Profile incl. "Messin' With The Kid," "Come On In This House," "Little By Little" (#23 R&B, '60), all live staples of his career; boogaloo blues "You're Tuff Enough" made #40 R&B ('68). Teamed w/Buddy Guy in '58, cut landmark LP HOODOO MAN BLUES for Delmark ('65). J JW & BG made US State Dept. tour of East Africa, and more LPs and many gigs together incl. BUDDY & THE JUNIORS ('70), ORIGINAL BLUES BROTHERS ('83), etc. JW's final album, COME ON IN THIS HOUSE, won a W.C. Handy Blues Award and Grammy nomination. Diagnosed w/lymphoma in August '97, he fell into coma following heart attack. Died 1.15.1998, only age 63."

[lifesciencesblogss]

T Cell Therapy Market Analysis Report - Size & Share 2030

T-cell therapy is revolutionizing the field of cancer therapy by giving hope to patients suffering from previously untreatable diseases. This innovative therapy establishes the power of immune cells that target and destroy cancerous cells. The industry in this field is expected to undergo significant growth due to the increase in technological advancements, more regulatory approvals, and a growing pipeline of promising therapies.

Market Overview

The global market for T-cell therapy is growing at a very high rate, mainly due to the rapid growth in the prevalence of cancer and the limited availability of conventional treatment modalities. This market is primarily driven by the development of chimeric antigen receptor T cell therapy, wherein T cells are engineered to recognize antigens particular to cancer.

The T cell therapy market size was US$ 2,754.0 million in 2022 and will grow at a rate of US$ 9,035.01 million by 2030; the market is expected to register a CAGR of 16.0% during 2022–2030.

Key Market Drivers

Rising Cancer Incidence: Increasing rates of cancers across the world have created a dire need for effective and targeted therapies. T-cell therapy is promising in such a scenario, especially in advanced or refractory cancers.

Technological Advancements: Continuous advancement in cell engineering and genetic modification methodology makes it possible to develop more potent and specific T-cell therapy.

The potential improvements in therapeutic outcomes and widened therapeutic windows are within innovations.

Regulatory Approvals: The potential of T cell therapy is increasingly being acknowledged by all regulatory bodies, with approved treatments gaining foot. Regulatory support has accelerated the adoption and created new opportunities in the market.

Prosperous Pipeline of Therapies: With a strong pipeline of T cell therapies in development, targeting a huge variety of cancer types, is designed to overcome the shortcomings of existing therapies and help provide a much better and longer-lasting response.

Market Segmentation

By Modality

Research and Commercialized

By Therapy Type

CAR T-cell Therapy

T-cell Receptor-based

By Indication

Hematologic Malignancies and Solid Tumors

By Region

North America

Europe

Asia-Pacific

South and Central America

Middle East and Africa

Market leaders and key company profiles

Immunocore Holdings Plc

Legend Biotech Corp

Janssen Global Services LLC

Gilead Sciences Inc

Bristol-Myers Squibb Co

Bluebird Bio Inc

Novartis AG

JW (Cayman) Therapeutics Co Ltd

Cartesian Therapeutics Inc

Challenges and Opportunities

Although the T-cell therapy market appears to be extremely promising, some serious challenges are still limiting its wide use at this moment:

High Cost of Treatment: T-cell therapies are expensive and therefore not accessible to many patients.

Side Effects These therapeutic approaches can cause severe side effects, including cytokine release syndrome and neurotoxicity, and hence have to be observed and managed very closely.

Manufacturing Complexity - The process for T cell therapies is highly complex and requires highly skilled labor with proper facilities.

However, the T cell therapy market does offer a lot of opportunities:

Combination Therapies—Combining T-cell therapy with other treatment modalities, such as chemotherapy or immunotherapy, can improve the effectiveness of the treatment and overcome some forms of resistance.

Allogeneic T Cell Therapies: Allogeneic T-cell therapies, derived from donor cells, are more accessible and scalable compared to autologous therapies.

Targeted Therapies: T-cell therapies targeted toward particular tumor antigens may lead to higher precision in the treatment and less off-target effects.

Conclusion

The T cell therapy market is at the edge of its revolutionizing change, where this therapy might change the fate of the treatment of cancer. R and D continued to progress and enhance, and more innovative and effective therapies can expectably roll out. With such challenges and opportunities, the T-cell therapy market can realize its goal to make improvements in patient outcomes and save lives.

FAQs-

Which is the largest regional market for T Cell Therapy?

Ans: - Asia Pacific is the largest regional market for T Cell Therapy.

Which are the top companies to hold the market share in the T Cell Therapy market?

Ans: These are the top companies that will hold the market share including Holdings Plc, Legend Biotech Corp, Janssen Global Services LLC, Gilead Sciences Inc, Bristol-Myers Squibb Co, Bluebird Bio Inc, Novartis AG, JW (Cayman) Therapeutics Co Ltd, Cartesian Therapeutics Inc, and Innovent Biologics Inc.

What growth rate will the market be projected to grow during the forecast period of 2022 to 2030?

Ans: - The T Cell Therapy market is likely to register a growth rate of 16.0% during the forecasting period of 2030.

How big is the T Cell Therapy market?

Ans: - The size of the global T Cell Therapy market was valued at US$ 2,754.0 million in 2022 and is expected to reach US$ 9,035.01 million by 2030.

What are the key segments of the T Cell Therapy market?

Ans: - The T Cell Therapy market is segmented into Modality, Therapy Type, Indication, and region.

About Us-

The Insight Partners is among the leading market research and consulting firms in the world. We take pride in delivering exclusive reports along with sophisticated strategic and tactical insights into the industry. Reports are generated through a combination of primary and secondary research, solely aimed at giving our clientele a knowledge-based insight into the market and domain. This is done to assist clients in making wiser business decisions. A holistic perspective in every study undertaken forms an integral part of our research methodology and makes the report unique and reliable.

[skyquesttinsights]

Cell Therapy Industry: Trends and Market Insights 2024-2031

In recent years, cell therapy has emerged as a revolutionary approach in the realm of medical treatments, offering promising solutions for various chronic and life-threatening conditions. This innovative field harnesses the potential of living cells to treat diseases by repairing or replacing damaged tissues and organs. The cell therapy market is experiencing significant growth, driven by advancements in technology, increased research and development activities, and a rising prevalence of chronic diseases.

According to recent industry reports, the global cell therapy market is on a robust growth trajectory. Global Cell Therapy Market size was valued at USD 3.9 Billion in 2022 and is poised to grow from USD 6.7 Billion in 2023 to USD 190.91 Billion by 2031, growing at a CAGR of 52% during the forecast period (2024-2031). This growth is attributed to several factors, including technological advancements, a surge in clinical trials, and the increasing demand for personalized medicine.

Get Your Free Sample Report Here @ https://www.skyquestt.com/sample-request/cell-therapy-market

Key Market Drivers

1. Technological Advancements: Breakthroughs in cell processing technologies, gene editing techniques such as CRISPR, and improvements in manufacturing processes are driving the market. These advancements enhance the efficacy and safety of cell therapies, making them more accessible and effective for patients.

2. Rising Prevalence of Chronic Diseases: The growing incidence of chronic conditions such as cancer, cardiovascular diseases, and autoimmune disorders is fueling the demand for cell-based treatments. Cell therapy offers potential cures and long-term solutions for these persistent health challenges.

3. Increased Research and Development: Ongoing research efforts and clinical trials are expanding the applications of cell therapy. Investment in R&D by pharmaceutical companies and biotech firms is crucial for discovering new therapies and improving existing ones.

4. Regulatory Support: Regulatory agencies are increasingly providing clearer pathways for the approval and commercialization of cell therapies. This supportive regulatory environment is crucial for accelerating the development and market entry of new treatments.

Market Segmentation

The cell therapy market is segmented based on cell type, application, and geography.

- By Cell Type: The market includes various types of cells such as stem cells, T-cells, and dendritic cells. Stem cell therapies are particularly prominent due to their potential in regenerative medicine.

- By Application: Applications span across oncology, cardiovascular diseases, neurological disorders, and more. Oncology holds a significant share, driven by the development of CAR-T cell therapies.

- By Geography: North America dominates the market, followed by Europe and the Asia-Pacific region. The strong presence of key players and advanced healthcare infrastructure contribute to North America's leading position.

To establish the important thing traits, Ask Our Experts @ https://www.skyquestt.com/speak-with-analyst/cell-therapy-market

Cell Therapy Market Top Players' Company Profiles - Thermo Fisher Scientific, Inc., Merck KGaA, Danaher Corporation, Becton, Dickinson, and Company, Lonza Group, Sartorius AG, Nkarta, Inc., Aurion Biotech, S. BIOMEDICS, MEDIPOST, Anterogen Co., Ltd., JW Therapeutics, JCR Pharmaceuticals Co., Ltd., Johnson & Johnson Services, Inc, Bristol-Myers Squibb Company, Gilead Sciences, Inc., Novartis AG, Intellia Therapeutics, Iovance Therapeutics, CRISPR Therapeutics

Challenges and Opportunities

Despite its promising prospects, the cell therapy market faces several challenges, including high treatment costs, complex manufacturing processes, and regulatory hurdles. However, these challenges also present opportunities for innovation and improvement. Advances in manufacturing technologies, cost reduction strategies, and streamlined regulatory processes could further propel the growth of the market. The cell therapy market is poised for significant growth, driven by technological advancements, rising disease prevalence, and supportive regulatory environments. As the field continues to evolve, it holds the potential to transform the landscape of medical treatments and improve patient outcomes worldwide. Stakeholders in the healthcare industry must stay abreast of these developments to capitalize on the opportunities presented by this dynamic market.

[waifu4waifu]

did anyone else lie on the myers briggs test, deprive themselves of sleep, dump a ton of sugar in their coffee, and sit stupid to be like L in their tweens jw

[jcolesonsofflinc]

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🌟 Choose J.W. Cole & Sons for your next furniture move and experience:

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To find out more, simply contact J.W. Cole & Sons of Florida, Inc. at 239-694-3400 or message us online at https://www.jwcoleatlas.com/contact-us/

[bl00dline]

I found a picture of sheet music for On a Sunday Afternoon, and on the cover are the Three Keaton’s! I decided to look the song up, and there are recordings (not of the Keaton’s, unfortunately) of the song from 1902!

https://youtu.be/cX_TeUB2TSo

[worldlykid]

Do other Ex JWs know about Meg Myers or is it just me who went through that phase

[doorsangel]

Come, children of light

[celmation-gibson]

Hello, Well 2018 was a Great time for Cinemas, and what a Year for such Creature Features such as the ones I will be reviewing here, and now may I present to you some reviews of the movies that I've observed on the Big Screen that year.

Pacific Rim: Uprising – My First movie to see in Theaters since I couldn’t find a Perfect time to see Aardman’s ‘Early Man’, but I’m pretty sure this Year would be a Monster of a Movie experience in the Cinemas. Since I’ve have and Watched the First film on DVD, I would think that I should enjoy its Sequel that has been made, and even though Mr. Guillermo Del Toro (the first film’s Director) didn’t direct this Film, he Helped Produce it as well. And as I said before, I do Love a Good Giant monster film, and this film was always filled with Suspense, Action, & Drama, and I would Fear that there won’t be any Hope left if those Giant Monsters win. Also it breaks my Heart wide Open to see a Character who I say and Liked in the First film died in this one. And that one Villainous Character is sure a Wicked Dick (*pardon my Language*) about this one being Possessed by a Kaiju Masterminded Brain. And surprising how that Rouge Jaeger was controlled by a Kaiju Brain, Hit him once & he’ll hit you back Twice as Hard. But I’m glad the heroes win in this Battle, and it took near the Tail end of the Film for the Movie’s Title to appear, unlike the First one where you wait 15-20 minutes for the Main Title to appear in a longest prologue, but for Me, I would almost stick with the Original Film.

Rampage – As I said before, I do Love a Good Giant monster Movie, and this is one of them. And it was a God-Epic monster Mash, even had some hilarious Moments, like when George flips the Bird, and I was like “Did that Primate just flip a Bird?”, though I do know another Ape who can Flip a Bird. And not to mention that the movie is actually based off an Old Arcade game of the same name, and if you Look very closely in the Office Building of Energyne, there are Arcade Cabinets of the Original ‘Rampage’ game, and ‘Rampage: World Tour(?), though I’m not quite sure what the other one is. And the monsters are Hardcore Badass, I don’t know which one(s) are Great (though I pick all of them), and for Bonus, there was another Creature in the Beginning of this Film that was a Rat Test subject. And the Sequence where they hunt the Giant Wolf Down was Awesome and it gave me Goosebumps completely. Plus some Good Elements from the Game is Included as Well, such as Eating People, Tearing down a Building from top to bottom, the military being involved, and Destruction of the monsters themselves. Even when me and my Dad were watching it in the Theaters, and when Dad watched the Commercials for the Film, one of his Favorite Quotes from the movie was “And of course the Wolf Flies”, LOL! And the Lizard Monster in the Film was so Massive & a “Pain in the Ass”, there was no End in that Creature, even when you plant an Explosion in his Ears & throw Missiles at him, he gets back up again, and I thought the Impalement on George would have Killed him Completely, but it was just thru his Shoulders and Thank goodness not the Heart Area or Between the Chests. But still, this film was an Epic Fun Thrillride, the characters are Great & Fun-filled, and I guaranteed this Year would be a Monster Movie Experience in the Theaters.

Jurassic World: Fallen Kingdom - Well, me and my Dad seen the first 'Jurassic World' in Theaters back in 2015, so we figured since we love Dinosaur movies, we go this this latest update, and to our Surprise, Original Jurassic Park star Mr. Jeff Goldblum (the big Chill, the Fly(1986)) will be starring in Guest Role, and it was a Surprise seeing him in a Honda(?) commercial to promote the Film. And That my Foodtown was already selling products, even sodas & Chips in Promoting the Features, and it featured some of my Favorite Dinosaurs in the Film such as the Classic T-Rex, and boy was that Opening Scene in the Pouring Rain so Intense, the Surviving Raptor of the Original JW film Blue, who is one of my Favorite 'Good Guy' Raptors, the Comical Dino Hard-head Stiggy, who I find entertaining & Funny in the Movie, and My Favorite Villainous Dinosaur, the IndoRaptor, and if you think the Indomenous Rex in 'Jurassic World' was Terrifying, this IndoRaptor is one Badass Creep, even when she(?) smiles while playing Dead while one of the Soldier guys was about to Chip a Tooth off her, kinda gives it like a Cartoon-y feel to it like the minor ones in 'the Adventures of Pinocchio'(1996). And that Epic moment where the Island was in Volcanic Eruption was so Frantic, even one scene in the Film was shot in One single Lengthy shot during those Round Vehicle Thingies, an I thought the Part where one of the Brachiosaurus was Left behind on the Island while Massive smoke was covering him was the most Disturbed sequences in the Film. Well i certainly enjoyed the film, while my Daddy didn't, cuz he thought there wasn't much action or creature footage in the film, as he thought there was more of some "Love Stories" being put into it, that's why he might like 'Rampage' more, where they showed some monsters earlier in the film, but you might say that some Critics praised Pratt's and Howard's performance, Bayona's direction, the visuals, Michael Giacchino's score and the "surprisingly dark moments", while others suggested the series had run its course, criticizing the screenplay and lack of innovation.

Hotel Transylvania 3: Summer Vacation - Well, Mr. Genndy Tartakovsky Never Fails to impress us with this Three-times Charmer, and how Lucky was I to reserve a Seating to see this on my Birthday of 2018, after a Good Morning at the Meadowlands flea Market, and a goof Lunch at Taco Bell, I hit the Theaters with my Dad, and the Movie was Fantastic, and since Mr. Genndy Tartakovsky Co-written this Film (along with one of the 'Austin Powers' writer), I know what some Moments in the Film, there are certain scenes that are free of Dialogue, just like the ones in 'Samurai Jack'. And it was a-bit strange to see a Character from one the 'Hotel Transylvania' shorts that I've never seen, and that short was "Puppy", but in order to watch the short (even for myself), I have to watch that Gross-out 'Emoji movie' for it. But for HT3, the Climatic part of the DJ Battle with Professor Van Helsing (Drac's old Nemesis, and was surprise to see him still Alive in Machine parts) & the Kraken was Awesome, I didn't remember the first Official song played, but I do know the second being 'Don't Worry, be Happy', and the Final one was none other than the 'Macarena' and supposedly it's the Extended River remix version of the song which I have on my I-Tunes and have no regret in Purchasing it, along with Daft Punk's 'One More Time'. So I like the Film and can't wait to get it for Christmas, along with 'Rampage' this Year. And I even heard that Genndy will be working more at SPA where he will be set to Direct an R-rated animated feature titled 'Fixed', and an Adventure Film named 'Black Knight'.

Smallfoot - When I saw some Preview ads on CartoonBrew, I thought this looks kinda Weird and thought I'd just pass on it, but after seeing some TV Ads for the film, and seeing how interesting it looks, I thought I'd give it a shot, and kinda find the movie very Interesting if you wanna feel Young at Heart, and was Lucky to see it on Columbus Day, the only Actor(s) in the Cast i know were comedian Danny Devito & Basketball superstar Lebron James, and to my surprise seeing the closing credit of the film that Cartoonist Justin Roiland voiced in the film as well as one of the Yeti folks in the Kingdom, and I only know the names Common & Gina Rodriguez starring in the film. And the Music and songs in the Film are Nice, and I like how some Advance the Characters or Advance the plot, and it was Hilarious hearing one Song being sung in the tune of Queen/David Bowie's 'Under Pressure', and since Common is a Rapper in real-life, he did a Good Singing on when the Stonekeeper himself tells Migo that Humans & Yetis were Enemies in the old ages. And the other reasone I like watching this film is that I'm also Fascinated with Yetis and Drawing them, as you can see from my old 'YETI & other Stories' story in my Gallery, and one of my Yeti inspirations was the old Unfinished/soon-to-be-Finished David Allen film 'the Primevals'. And don't forget that the SF film was inspired by a book called 'Yeti Tracks', which is a good thing that some Films were based on Books such as 'Mr. Popper's Penguins', 'Home', & 'the Adventures of Pinocchio(1996)'. And I like how the Film was promoted "from the Studio who brought you 'Looney Tunes'" in which case, it is made by Warner Bros., and also the people who worked on 'Storks', and this film now made me think of two Environmental Animated films from 20th century Fox such as 'Ferngully: the Last Rainforest' & 'Once upon a Forest'.

Halloween(2018) - I never even heard that the Original 1978 classic is getting a Remake, although It may not look like a remake, but a True sequel to the Original film, and avoiding stuff on what happened in 'Halloween II(1981)', 'Halloween 4 -Curse', & 'H20'. And I read that the original star Ms. Jamie Lee Curtis will be in this Film, as well as being executive producer for the feature along with the Original 1978 Film's Director Mr. John Carpenter, as in they want to make it look Perfect as the original Monsterpiece, and they did succeed in it in Keeping the Spirit & Atmosphere like the 1978 movie. And I gotta say, Micheal Myers is one 'Pain-in-the-Ass' monster in this Film, like he always is in the original series, and I feel sorry for the People who got killed by that Creep, the Podcasters, the Boy who was equipped with a Gun along with his daddy, and a Woman who Micheal murdered and left a Baby behind. And an amazing thing my dad found in a Twist of Story is when Micheal got hit by the Sheriff, the Sheriff and the Late Dr. Loomis' student professor went out to investigate and kill Micheal, only for the Sheriff to be killed by the Professor, and when the Professor dude wore Micheal's mask, my dad thought that he was gonna be the New Micheal Myers, but Micheal resurfaced and soon killed the Professor afterwards. And one part in the Film which left the Audience in an applause is a Sequence that was based off the Original film, when Micheal attacked Laurie and pushed her off the Balcony, he saw her Body Lying there, but when Micheal turned away and looked back again, she was gone, just like what happened in the 1978's film ending. even after watching this film with my dad, he still had alot of Questions need to be Answered about some parts in the film, and I wish they showed more of the Ending with Micheal being Burned alive in the Cellar. And this may be one Creepy Classic that i might never watch again, but I just stick with the original Masterpiece of Fright & Shock.

the Grinch - Man, I am seeing alot of Good films in 2018, and this one may be the Last that interest me that Year, and this one was an Adaption of Dr. Suess' Classic Holiday Tale, 'How the Grinch stole Christmas', or simply titled 'the Grinch'. And seeing how Interesting it looks after seeing some Previews and TV Ads, especially that part where the Grinch whispers to Max and Fred "This is the Loudest Snow I've ever heard in my Life", I've decided to give it a Go, and hoping to see if it's Fascinating like the Original 1966 Animated Classic and more Better than the 2000 Live-Action Jim Carrey one, and it was. How lucky i was to see this movie on a Day off afternoon on a Wednesday, and I thought i would be the only one seeing the Film in Theaters, but it was also some Girls and their Parents & Guardians, possibly had a Half a day off. But for the Film, I Loved how the Narrator of the Film narrates in Rhyme, like the Original Dr. Suess books, and how the Writers improvised the Story using the same Lines in the Books, and It had a Great choices in Christmas soundtrack, especially in the part with Grinch Wake-up Radio with some Familiar tunes I know and Cherished. And it was a Great Film produced by the Wonders of Illumination, the Wizards behind 'Despicable me', 'the Secret Life of Pets', & 'Sing', plus they did another Dr. Sues adaption such as 'the Lorax', even some of the character designs in the film made me think of the Designs from Disney features such as 'Wreck-It Ralph' & 'Monster University'. And some of the Voice Cast in the film I know of was Keenan Thompson of 'All That' & 'Keenan & Kel' voicing Bricklebaum, a jolly citizen of Whoville, and Angela Lansbury as the Whoville's Mayor, and how Surprised/Not Surprised to hear another Familiar Voice in the Film playing one of Cindy Lou's Friends, who that boy is none other than Mr. Sam Lavagnino, the Voice of Baby Grizz in 'We Bare Bears' & Pepper and Alien King in 'Summer Camp Island'. And I'd thought Ms. Cindy Lou Who would have a cute design just like the one in the 1966 Classic, and she did have a Cuter design in this Film when it comes to the Creative Artists of Illumination. And Yet, this has become another Holiday Classic, and when I told my Mother how much Fun it is, she might be hoping to get the Film on DVD for my Niece to Enjoy.

There was a Movie called 'the Meg', though I may have interest to see that, but I wasn't sure how much interested I will be with the Whole thing. And sorry if I didn't felt like seeing 'Ralph breaks the Internet' or 'Into the Spider-Verse', I go for the Obscure & Non-Disney taste in the Cinemas as of now.

[onejamtart]

JUST MERCY | Main Trailer

From Warner Bros, “Award-winning filmmaker Destin Daniel Cretton (“The Glass Castle,” “Short Term 12”) directed the film from a screenplay he co-wrote, based on the award-winning nonfiction bestseller by Bryan Stevenson. A powerful and thought-provoking true story, “Just Mercy” follows young lawyer Bryan Stevenson (Jordan) and his history-making battle for justice.  After graduating from Harvard, Bryan had his pick of lucrative jobs.  Instead, he heads to Alabama to defend those wrongly condemned or who were not afforded proper representation, with the support of local advocate Eva Ansley (Larson).  One of his first, and most incendiary, cases is that of Walter McMillian (Foxx), who, in 1987, was sentenced to die for the notorious murder of an 18-year-old girl, despite a preponderance of evidence proving his innocence and the fact that the only testimony against him came from a criminal with a motive to lie.  In the years that follow, Bryan becomes embroiled in a labyrinth of legal and political maneuverings and overt and unabashed racism as he fights for Walter, and others like him, with the odds—and the system—stacked against them. The main cast also includes Rob Morgan (“Mudbound”) as Herbert Richardson, a fellow prisoner who also sits on death row awaiting his fate; Tim Blake Nelson (“Wormwood”) as Ralph Myers, whose pivotal testimony against Walter McMillian is called into question; Rafe Spall as Tommy Chapman, the DA who is fighting to uphold Walter’s conviction and sentence; and O’Shea Jackson Jr. (“Straight Outta Compton”) as Anthony Ray Hinton, another wrongly convicted death row inmate whose cause is taken up by Bryan.”

Peace, JW

[phdsobko]

“Study of Signaling in Axolotl Development and Regeneration” Research Statement by Alex Sobko, PhD from Alexander Sobko on Vimeo.

“Study of Signaling in Axolotl Development and Regeneration” Research Statement by Alex Sobko, PhD

References:

Bassat E, Tanaka EM. The cellular and signaling dynamics of salamander limb regeneration. Curr Opin Cell Biol. 2021 Dec;73:117-123.

Tanaka EM. The Molecular and Cellular Choreography of Appendage Regeneration. Cell. 2016 Jun 16;165(7):1598-1608.

Haas BJ, Whited JL. Advances in Decoding Axolotl Limb Regeneration. Trends Genet. 2017 Aug;33(8):553-565.

Nowoshilow S, Schloissnig S, Fei JF, Dahl A, Pang AWC, Pippel M, Winkler S, Hastie AR, Young G, Roscito JG, Falcon F, Knapp D, Powell S, Cruz A, Cao H, Habermann B, Hiller M, Tanaka EM, Myers EW. The axolotl genome and the evolution of key tissue formation regulators. Nature. 2018 Feb 1;554(7690):50-55.

Yun MH, Davaapil H, Brockes JP. Recurrent turnover of senescent cells during regeneration of a complex structure. Elife. 2015 May 5;4:e05505.

Debuque RJ, Nowoshilow S, Chan KE, Rosenthal NA, Godwin JW. Distinct toll-like receptor signaling in the salamander response to tissue damage. Dev Dyn. 2022 Jun;251(6):988-1003.

Sobko A. Principles and Significance of Base Editing and Prime Editing. Preprint. doi.org/10.31219/osf.io/xekyn.

Sobko A. Cell biologist’s perspective: Frontiers in Development of PROTAC-HDAC degraders. Preprint. doi.org/10.31219/osf.io/vua9r.

Sobko A. Cell Systems Biology of Translation Factors and Proteasome- Targeted Protein Complexes Associated with AGC Kinase Sch-9. J Mol Genet Med 15, 2021: 470.

Sobko A. A hypothetical MEK1-MIP1-SMEK multiprotein signaling complex may function in Dictyostelium and mammalian cells. Int J Dev Biol. 2020;64(10-11-12):495-498.

Sobko A. Systems biology of AGC kinases in fungi. Science Signaling (STKE). 2006 Sep 12;2006(352):re9.

Sobko A, Ma H, Firtel RA. Regulated SUMOylation and ubiquitination of DdMEK1 is required for proper chemotaxis. Dev Cell. 2002 Jun;2(6):745- 56.

© 2020-2022, Alex Sobko, PhD © 2022, Record, design, photo, edit, posts at social media by Alex Sobko, PhD, 8762728, South-West IL (ישראל)

[bl00dline]

30 questions game :)

Sorry I forgot to do this yesterday! I was tagged by @prideofnewberk and @not-doom-guy. Thank you lovelies!! 💗

Rules: answer 30 questions and tag 20 blogs you are contractually obligated to know better!

1. Name/nickname: Shannon

2. Gender: Female

3. Star sign: Scorpio

4. Height: 5’0 (154 cm)

5. Time: 3:46 pm

6. Birthday: November 16

7. Favourite bands: The Paul Whiteman Orchestra maybe? Or The Glenn Miller Orchestra

8. Favourite solo artists: Ohhhh boy there are so many. Bix Beiderbecke, Al Bowlly, Annette Hanshaw, Claude Debussy, and probably a lot I don’t remember

9. Song stuck in my head: On a Sunday Afternoon by JW Myers

10. Last movie: I can’t remember the title but it had Roscoe Arbuckle and Al St John. It’s from 1932 or 1933 I think, it’s a talkie and it’s very chaotic

11. Last show: Frasier

12. When I created this blog: April of 2019

13. What I post: Mostly Buster Keaton, with occasional other old Hollywood stuff, history, art, and memes

14. Last thing I googled: Agnes Bings. She was murdered in Victoria in 1899 and it’s actually a pretty interesting case

15. Other blogs: @vintage-knitting (my knitting blog), @the-anxious-dead (my WWI blog), @goodnight-seattle (my Frasier blog), and @thesoundofsilents (the blog I share with my darling friend @silverscene!)

16. Do I get asks: Not on a regular basis, but yes!

17. Why I chose this url: It’s sort of an interesting story. When I changed it from 1920s-obsessed, I initially changed it to buster-keatcn because I figured that buster-keaton was taken. Only a day or so later, I decided to check if it was taken, and I was shocked to find out that it wasn’t taken! I doubt i’ll change it now, because I was pretty lucky that it was available

18. Following: 264

19. Followers: 962

20. Average hours of sleep: Usually between 3-7. I really need more sleep :’)

21. Lucky number: 25

22. Instruments: I used to play the clarinet but I sucked at it. I want to learn how to play the ukulele though

23. What I’m wearing: A white blouse with a black cardigan and a long, striped grey skirt.

24. Dream job: Historian and historical re-enactor

25. Dream trip: Definitely to the UK, France, and Belgium!

26. Favourite food: Roast beef and mashed potatoes, probably

27: Nationality: I’m Canadian, and my heritage is English, Belgian, and Irish

28. Favourite song: I’m sorry but this is impossible

29. Last book read: b l e a k h o u s e

Honestly I should give up reading it because I really have no time to read it. But anyways

30. Top three fictional universes I'd like to live in: Honestly I have no idea, maybe if I were to pick specific shows and movies it would be His Wedding Night, Houdini and Doyle, and The General?

I’m tagging @alfred-st-john, @silverscene, @nitrateglow, @thehighsign, @schofielded, @miss-amna, @a-british-guardsman, @my-little-kraken, @busterverse, @trainrideswithbuster, @lukethewanderer, @vintage-vermillion, @heavy-focking-metal, @hildy-dont-be-hasty, @percysblakeney, @rememberedkisses, @rubinstein1798, @thesovietskeleton, @home-boi-yawn, and @squirrellocked, if any of you would like to do this 💗💗💗