#is super interesting.

[stagefoureddiediaz]

Ohhhhhh!!

The Shannon saying to Eddie at the lake she thought he was someone else and Buck confusing who he has feelings for and ending up dating Tommy parallel!!!

[reasonsforhope]

A new treatment combining ReCET and semaglutide could eliminate the need for insulin in type 2 diabetes, with 86% of participants in a study no longer requiring insulin therapy. The treatment was safe and well-tolerated, and further trials are planned to confirm these results.

Groundbreaking research presented at UEG Week 2024 introduces a promising new treatment approach for type 2 diabetes (T2D) that has the potential to greatly reduce or even eliminate the need for insulin therapy.

This innovative approach, which combines a novel procedure known as ReCET (Re-Cellularization via Electroporation Therapy) with semaglutide, resulted in the elimination of insulin therapy for 86% of patients.

Globally, T2D affects 422 million people... While insulin therapy is commonly used to manage blood sugar levels in T2D patients, it can result in side effects... and further complicate diabetes management. [Note: Also very importantly it's fucking bankrupting people who need it!!] A need therefore exists for alternative treatment strategies.

Study Design and Outcomes

The first-in-human study included 14 participants aged 28 to 75 years, with body mass indices ranging from 24 to 40 kg/m². Each participant underwent the ReCET procedure under deep sedation, a treatment intended to improve the body’s sensitivity to its own insulin. Following the procedure, participants adhered to a two-week isocaloric liquid diet, after which semaglutide was gradually titrated up to 1mg/week.

Remarkably, at the 6- and 12-month follow-up, 86% of participants (12 out of 14) no longer required insulin therapy, and this success continued through the 24-month follow-up. In these cases, all patients maintained glycaemic control, with HbA1c levels remaining below 7.5%.

Tolerability and Safety

The maximum dose of semaglutide was well-tolerated by 93% of participants, one individual could not increase to the maximum dose due to nausea. All patients successfully completed the ReCET procedure, and no serious adverse effects were reported.

Dr Celine Busch, lead author of the study, commented, “These findings are very encouraging, suggesting that ReCET is a safe and feasible procedure that, when combined with semaglutide, can effectively eliminate the need for insulin therapy.”

“Unlike drug therapy, which requires daily medication adherence, ReCET is compliance-free [meaning: you don't have to take it every day], addressing the critical issue of ongoing patient adherence in the management of T2D. In addition, the treatment is disease-modifying: it improves the patient’s sensitivity to their own (endogenous) insulin, tackling the root cause of the disease, as opposed to currently available drug therapies, that are at best disease-controlling.”

Looking ahead, the researchers plan to conduct larger randomized controlled trials to further validate these findings. Dr. Busch added, “We are currently conducting the EMINENT-2 trial with the same inclusion and exclusion criteria and administration of semaglutide, but with either a sham procedure or ReCET. This study will also include mechanistic assessments to evaluate the underlying mechanism of ReCET.”

-via SciTechDaily, October 17, 2024

--

Note: If it works even half as well as suggested, this could free so many people from the burden of the ongoing ridiculous cost of insulin. Pharma companies that make insulin can go choke (hopefully).

[chloesimaginationthings]

What FNAF movie Vanessa’s REAL job is..

[noodles-and-tea]

I love the way you draw and portray young Stan! Could you draw him being possessed by Bill?

I love that sweet kid you draw!! Can you make him suffer more please?

[choccy-milky]

@foundthatoldzeppelinshirt what did u do to me...what in the wattpad is this... i only planned to do a few doodles but then i kept getting more brainrotted and things got out of hand LMAOO (and ofc i HAD to draw hockey player seb at SOME POINT bc its my duty as a canadian citizen🫡🍁🍁 O CANADA!!!)

[ale-arro]

been going a little bit insane about this sentence from Ace by Angela Chen for the past week

[gingerswagfreckles]

It's also a little bit funny that other people are calling the guy who shot a healthcare CEO with bullets that said "deny defend depose" and was carrying a manifesto about how corporate America is evil a "Nikki Haley Republican" or part of the "center right." I guess based on the fact that he went to an expensive private school was messing around in Hawaii pretending to develop a video game as work until recently? Like. This guy left a goodreads review about how the Unibomber was an "extreme political revolutionary." While also traveling around the world on the money his parents made off of real estate and owning a chain of senior rehabilitation facilities.

I think a lot of you are really uncomfortable with how common champagne socialism is and frankly I think a lot of this is projection. This guy is very obviously someone who considers themselves a leftist revolutionary, and yet everyone is kind of re-framing him as a "Nikki Haley Republican" because they're uncomfortable with acknowledging that far leftists are often very privileged and hypocritical people. I've been talking about this for a long time, but a lot of the left (at least on the internet) is quite in denial about the fact that a lot of their beliefs aren't widely shared by the working class. That often, the loudest voices in the movement are those belonging to the wealthy, who are at the end of the day cosplaying and are more interested in acting out heroic fantasies than improving life for the working class.

[triona-tribblescore]

TW// Abuse implication

Thinking about possible Vox and Angel's interactions and how they'd go down. Theres such a unique mix of hatred to each other and common ground with their different experiences with Valentino, has me thinking.

Also just want to clarify I love Vox's character a LOT but ofc obv don't sympathise with him or think he is any way shape or form a decent individual, cant with stupid toxic dumbass x

AND IF YOU SEE ANY MISTAKES OR TYPOS NO YOU DONT- (i was so tired when drawing it forgive me TwT)

[specialagentartemis]

Reading (listening to, as Homer intended) the Iliad making me go oh. Ohhh. I should have done this before I read Gideon the Ninth. I get it now.

Particularly thinking now about the tidbit that in early drafts, our beloved gray-eyed Necromancer Warden of the Sixth House was named Diomedes Sextus. For Diomedes, king of Argos, young, brave, noble, heroic. Favorite fighter of Athena, bestest friend of Odysseus. And, notably, fought gods and—well he didn’t win exactly. But he got them good.

And specifically, he fought and wounded Aphrodite; Aphrodite, who is also called Cytherea.

And then of course Tamsyn Muir said she decided to change his name so she could make the Sex Pal joke.

Palamedes is a less heroic, less fondly remembered character in the Trojan War, but according to Plato, he unrelatedly invented both number and the alphabet, so you keep that connection to scholarship even if that’s not the first association with him. More interestingly, imo, there’s also an Arthurian Knight of the Round Table named Palamedes, best known for his unrequited love for Isolde (and his apparent ultimately gracious acceptance of her choosing Tristan).

I think this is actually a super interesting shift in thematic naming focus: from favored-of-Athena, fought-gods-and-wounded-them to unrequited heterosexual love, but didn’t act like a dick about it.

Also y’know. Sex Pal

[yanderespamton78]

Edit since a lot of people seem confused - your "real" name is the name that you want to be referred to in real life. It doesn't have to be your legal name. So if you're trans and you have a different name to whats on your birth certificate, even if not many people call you by the name, it still counts as your real name.

Edit 2 : Holy shit guys please stop reblogging this post my poor inbox im getting like 20 notifs an hour asjfhkajshdkh /lh /srs

[artzee534]

"Where have I seen this before?"

The individual frames:

Bonus: concerned brothers

[teenagenutant]

hi! i finally updated my fic pressure bomb so. doodles +lil' comic for chapter 3 & 4 ^^

[linktoo-doodles]

what kind of guy steals 10 doors instead of his tasked 5 just because he can

[chloesimaginationthings]

IDK what William Afton expected to happen in FNAF..

[krstsole]

Just wanna say that I think Ekko and Mel slander makes sense when you understand that 85% of the Arcane fandom views both of them as characters less worthy of fandom attention.

In their eyes, they are afterthoughts to more interesting relationships, so when someone in the 15% dares to give them anything outside of dutiful lamentations ("Mel and Ekko deserved better!"), they can't help but feel those analysis would be better suited for a character they *actually* like and so they lash out.

Fans of both characters have to constantly argue that these characters have loved and have been loved. They want Mel "independent" because she doesn't "need love" and they want Ekko focused on The Tree and the unnamed Firelights because they want it to be easier to carve both of them out of the interpersonal narratives that attaches fandoms to characters in the first place.

They want Mel and Ekko to "save the day" because they don't want their roles in the story to interfere with other characters that they like. Better for them to beat the Bad Guys™ than to be given more material that would validate their personal connections with other characters in ways that the fandom would prefer to ignore.

And the fact that Ekko and Mel are completely different characters who have never once interacted with each other and yet somehow both of them are being treated the same way with how the fandom constantly diminishes their relationships with the rest of the main cast leads me to believe that it does have something to do with the One Trait they do share.

[arsenicflame]

Bonus round! Do you use a queue tag?