#is super interesting.

[stagefoureddiediaz]

Ohhhhhh!!

The Shannon saying to Eddie at the lake she thought he was someone else and Buck confusing who he has feelings for and ending up dating Tommy parallel!!!

[reasonsforhope]

A new treatment combining ReCET and semaglutide could eliminate the need for insulin in type 2 diabetes, with 86% of participants in a study no longer requiring insulin therapy. The treatment was safe and well-tolerated, and further trials are planned to confirm these results.

Groundbreaking research presented at UEG Week 2024 introduces a promising new treatment approach for type 2 diabetes (T2D) that has the potential to greatly reduce or even eliminate the need for insulin therapy.

This innovative approach, which combines a novel procedure known as ReCET (Re-Cellularization via Electroporation Therapy) with semaglutide, resulted in the elimination of insulin therapy for 86% of patients.

Globally, T2D affects 422 million people... While insulin therapy is commonly used to manage blood sugar levels in T2D patients, it can result in side effects... and further complicate diabetes management. [Note: Also very importantly it's fucking bankrupting people who need it!!] A need therefore exists for alternative treatment strategies.

Study Design and Outcomes

The first-in-human study included 14 participants aged 28 to 75 years, with body mass indices ranging from 24 to 40 kg/m². Each participant underwent the ReCET procedure under deep sedation, a treatment intended to improve the body’s sensitivity to its own insulin. Following the procedure, participants adhered to a two-week isocaloric liquid diet, after which semaglutide was gradually titrated up to 1mg/week.

Remarkably, at the 6- and 12-month follow-up, 86% of participants (12 out of 14) no longer required insulin therapy, and this success continued through the 24-month follow-up. In these cases, all patients maintained glycaemic control, with HbA1c levels remaining below 7.5%.

Tolerability and Safety

The maximum dose of semaglutide was well-tolerated by 93% of participants, one individual could not increase to the maximum dose due to nausea. All patients successfully completed the ReCET procedure, and no serious adverse effects were reported.

Dr Celine Busch, lead author of the study, commented, “These findings are very encouraging, suggesting that ReCET is a safe and feasible procedure that, when combined with semaglutide, can effectively eliminate the need for insulin therapy.”

“Unlike drug therapy, which requires daily medication adherence, ReCET is compliance-free [meaning: you don't have to take it every day], addressing the critical issue of ongoing patient adherence in the management of T2D. In addition, the treatment is disease-modifying: it improves the patient’s sensitivity to their own (endogenous) insulin, tackling the root cause of the disease, as opposed to currently available drug therapies, that are at best disease-controlling.”

Looking ahead, the researchers plan to conduct larger randomized controlled trials to further validate these findings. Dr. Busch added, “We are currently conducting the EMINENT-2 trial with the same inclusion and exclusion criteria and administration of semaglutide, but with either a sham procedure or ReCET. This study will also include mechanistic assessments to evaluate the underlying mechanism of ReCET.”

-via SciTechDaily, October 17, 2024

--

Note: If it works even half as well as suggested, this could free so many people from the burden of the ongoing ridiculous cost of insulin. Pharma companies that make insulin can go choke (hopefully).

[chloesimaginationthings]

What FNAF movie Vanessa’s REAL job is..

[noodles-and-tea]

I love the way you draw and portray young Stan! Could you draw him being possessed by Bill?

I love that sweet kid you draw!! Can you make him suffer more please?

[yuri-puppies]

Shape-shifters, face-blindness, and "paying attention to others"

The shapeshifter is one of my favourite "monster of the week" episodes because it showcases how differently Laios processes social information than the rest of the party. It reminds me a lot of the strategies I, faceblind name-forgetter and eye-contact avoider, use to recognize people and learn things about them.

We see Laios clearly fail at recognizing the doubles through "standard" social cues that are perceived as "easy to tell", such as their clothes. This makes the team (unfairly, but understandably) weary of his ability to tell the fakes apart and even worried that he'd prefer the monster versions* over them. Nonetheless, he gives it a try!

...And is immediately overwhelmed. His lack of attention to social cues works a bit in his favor, though, as it makes it harder for him to fall for stereotypes that fool the rest of the group.

Instead, he chooses to rely on his strengths and use his investigation and animal handling skills to distract the shapeshifters, lure out the monster, and roll the most insane balls-to-the-wall intimidation check of all time.

If it had ended there it still would have been a great episode that showcases Laios' strategic mind and his strengths as a leader. He doesn't have the social skills necessary for the task, but he is clever and creative enough to use the skills he does have proficiency in to solve the problem*.

However, what makes this episode so dear and near to my faceblind heart is the revelation that Laios was able to recognize the real party members after all.

Laios is fantastic representation of how special interests actually work for a monotropic interest system. Having a special interest is not just about how much you like it and the need to know everything about it, it's a way of processing and filtering information. Laios' special interest is monsters: his skills as a dungeoneer and party leader are acquired for and informed by his desire to interact with monsters, as is his interest in eating them. He actually brings this up himself when comparing his interest in cooking to Senshi's.

And in this episode, we see that this also extends to his friends. Laios hacks one of the most difficult types of information for him to process by routing it through the lens of the special interest. And, because it's not something most people would notice, it works. He knows that Chilchuck wouldn't let his guard down around a potential mimic, that Senshi values a balanced ecosystem, that (my favourite) Marcille just isn't as thoughtful about monsters as he is.

It might not be what was expected, but it did the trick! And what's more, the narrative validates his way of thinking (even if Chilchuck doesn't).

[ale-arro]

been going a little bit insane about this sentence from Ace by Angela Chen for the past week

[triona-tribblescore]

TW// Abuse implication

Thinking about possible Vox and Angel's interactions and how they'd go down. Theres such a unique mix of hatred to each other and common ground with their different experiences with Valentino, has me thinking.

Also just want to clarify I love Vox's character a LOT but ofc obv don't sympathise with him or think he is any way shape or form a decent individual, cant with stupid toxic dumbass x

AND IF YOU SEE ANY MISTAKES OR TYPOS NO YOU DONT- (i was so tired when drawing it forgive me TwT)

[specialagentartemis]

Reading (listening to, as Homer intended) the Iliad making me go oh. Ohhh. I should have done this before I read Gideon the Ninth. I get it now.

Particularly thinking now about the tidbit that in early drafts, our beloved gray-eyed Necromancer Warden of the Sixth House was named Diomedes Sextus. For Diomedes, king of Argos, young, brave, noble, heroic. Favorite fighter of Athena, bestest friend of Odysseus. And, notably, fought gods and—well he didn’t win exactly. But he got them good.

And specifically, he fought and wounded Aphrodite; Aphrodite, who is also called Cytherea.

And then of course Tamsyn Muir said she decided to change his name so she could make the Sex Pal joke.

Palamedes is a less heroic, less fondly remembered character in the Trojan War, but according to Plato, he unrelatedly invented both number and the alphabet, so you keep that connection to scholarship even if that’s not the first association with him. More interestingly, imo, there’s also an Arthurian Knight of the Round Table named Palamedes, best known for his unrequited love for Isolde (and his apparent ultimately gracious acceptance of her choosing Tristan).

I think this is actually a super interesting shift in thematic naming focus: from favored-of-Athena, fought-gods-and-wounded-them to unrequited heterosexual love, but didn’t act like a dick about it.

Also y’know. Sex Pal

[yanderespamton78]

Edit since a lot of people seem confused - your "real" name is the name that you want to be referred to in real life. It doesn't have to be your legal name. So if you're trans and you have a different name to whats on your birth certificate, even if not many people call you by the name, it still counts as your real name.

Edit 2 : Holy shit guys please stop reblogging this post my poor inbox im getting like 20 notifs an hour asjfhkajshdkh /lh /srs

[artzee534]

"Where have I seen this before?"

The individual frames:

Bonus: concerned brothers

[teenagenutant]

hi! i finally updated my fic pressure bomb so. doodles +lil' comic for chapter 3 & 4 ^^

[linktoo-doodles]

what kind of guy steals 10 doors instead of his tasked 5 just because he can

[arsenicflame]

Bonus round! Do you use a queue tag?

[chloesimaginationthings]

IDK what William Afton expected to happen in FNAF..

[turtleblogatlast]

One of my favorite headcanons is that Leo grew up watching telenovelas with Splinter.

It just works so well - his bits of Spanish that he spouts randomly, his showy way of apologizing, and, of course, his love for dramatic betrayals all point to this being a very real possibility.

Plus, it’s very cute to imagine a tiny Leo at his father’s side as they both gasp in shock when the show’s eighth plot twist in just as many episodes happens.

[frodo-a-gogo]

Let us be brutally honest with ourselves and with eachother for a moment. If he weren't obese you motherfuckers would be capable of percieving evrart claires sexy sexy moral ambiguity and complex charms