#inhibitor

[identifying-cat-phenotypes]

I think my boy Lucifer is a black self with low white, but I'm not sure! He appears almost rusty red in sunlight with tabby stripes, and his black fur is white at the base as you can see on his arms in the first photo!

This lovely kitty looks like a black smoke with low white! What a gorgeous boy! His stripes are a result of ghost or phantom striping, where a cat is genetically solid but due to the smoke gene they appear striped.

[amber-tortoiseshell]

It's kinda weird to me that the whole point of silver is inhibiting phaeomelanin, but it doesn't turn red cats gray or white like you'd think... but yet the agouti gene doesn't affect red at all... red is so weird lol

Cat's orange is certainly something very unique and not like anything else in other animals.

On the other hand, I strongly believe every interaction or phenotype can be explained if we understand the molecular processes behind the pigment production, the roles of the color genes and the changes brought by their mutations. These things aren't random even if we don't understand them yet.

Agouti probably doesn't affect red because the protein it codes (ASIP) regulates eumelanin production (switches it over to phaeomelanin), and in reds eumelanin is impossible to produce, so there's nothing to regulate. Thus no effect.

And why does inhibitor leave red stripes? Well, I don't know, the exact pathway is still unknown, but the known silver loci are in non-coding, gene regulating areas of the genom, so they are affecting the phenotype through other gene(s). Maybe it's some tabby pattern gene that's only active during the "background" bands' pigmentation! Or maybe the inhibitor effect is only so strong, and to more pigmented stripes keep enough phaeomelanin to visually remain red. Or maybe the phaeomelanin produced in different agouti bands is slightly different, so they react to inhibitor differently. I'm sure we'll get the explanation someday.

[whats-in-a-sentence]

Australine was isolated from the seeds of the Australian tree Castanospermum australe (figure 19.17) and is also an inhibitor of glycoprocessing enzymes.

"Chemistry" 2e - Blackman, A., Bottle, S., Schmid, S., Mocerino, M., Wille, U.

[deadfileinthecabinet]

It’s also known as HVM-5. Known to enhance human abilities, but the first injection usually causes seizures, cardiac arrest and sometimes, death.

[sciencesolutions]

[amber-tortoiseshell]

Do cats with wideband(not sunshine) and silver exist? ive been looking for examples for ages

Yeah! You've probably already saw some, just didn't realize it. As wide band makes the yellow agouti bands wider, and silver removes the pheomelanin from these bands, wideband+silver makes mostly white cats. Their names work the same as the golden series: silver tabby (this is a bit unfortunate, since low grade wide band silver is called the same as no wide band silver), silver shaded (tabby), silver tipped, silver shell, silver chinchilla.

Black silver shaded tabby, with brick-red nose leather and black toebeans, characteristic to all black tabbies. This is reveals that this is not a dominant white (W_) cat.

[amber-tortoiseshell]

hello! this might be a stupid question but if smoke makes the hair roots white then why do the hair tips also become white? like the black smoke pictures you've been using for the tournament.

All right, that's actually a very good question, and I'm not entirely sure I can fully answer it. (I've never had a longhaired smoke in my hand, so i can only speculate based on pictures.)

Cats have different kind of hairs: guard hairs, awn hairs, down hairs. In a smoke, the hairs making up the undercoat are much lighter than the rest, the standard black with white base 'upper' hairs. I don't know what kind of hairs the "mane" of a norwegian forest cat with its coat at the fullest consists, but i suspect it's different then those covering the back and the sides of the cat, and that's why the white is much more apparent there.

One of the smoke cats I used in the tournament, Danoe's Mr Mistoffelees at different fur length stages:

[medchemexpressinhibitor-blog]

Unlocking the Potential of Pralsetinib: Key Facts You Should Know

In the realm of targeted cancer therapies, Pralsetinib has emerged as a groundbreaking option for patients with certain types of tumors. This innovative treatment has generated significant interest due to its specific action against genetic mutations that drive cancer growth. In this article, we will explore essential facts about Pralsetinib, including its mechanism of action, indications, safety profile, and impact on patient care.

1. What is Pralsetinib?

Pralsetinib is an oral tyrosine kinase inhibitor designed specifically to target rearranged during transfection (RET) alterations in various cancers. It has been approved for the treatment of adult patients with advanced or metastatic RET fusion-positive non-small cell lung cancer (NSCLC) and medullary thyroid cancer (MTC). By focusing on these specific mutations, Pralsetinib offers a precision medicine approach to cancer treatment.

2. Mechanism of Action

The efficacy of Pralsetinib lies in its ability to selectively inhibit the RET protein, which plays a significant role in cellular signaling pathways involved in tumor growth and survival. By blocking this pathway, Pralsetinib effectively disrupts the signals that promote cancer cell proliferation, leading to reduced tumor growth and improved patient outcomes. This targeted approach minimizes damage to healthy cells, which is a notable advantage over conventional chemotherapy.

3. Indications for Use

Pralsetinib is primarily indicated for:

Non-Small Cell Lung Cancer (NSCLC): Specifically for patients with RET fusion-positive NSCLC who have not received prior systemic therapy.

Medullary Thyroid Cancer (MTC): For patients with advanced MTC who require systemic therapy.

By addressing these specific malignancies, Pralsetinib provides a vital treatment option for patients with limited alternatives.

4. Safety Profile

Understanding the safety profile of Pralsetinib is crucial for healthcare providers and patients alike. In clinical studies, Pralsetinib has been generally well-tolerated, with common side effects including:

Fatigue

Nausea

Diarrhea

Hypertension

While most side effects are manageable, it is essential for patients to communicate openly with their healthcare team to monitor any adverse reactions and adjust treatment as necessary.

5. Administration and Dosage

Pralsetinib is administered orally, usually taken once daily. The specific dosage may vary based on individual patient factors and should be determined by a healthcare provider. This convenient oral formulation allows for flexible dosing schedules, enhancing patient adherence to treatment regimens.

6. The Future of Cancer Treatment

As research continues, the future of Pralsetinib looks promising. Ongoing clinical trials are exploring its effectiveness in additional cancer types with RET alterations and assessing combination therapies to enhance its therapeutic impact. As our understanding of targeted therapies evolves, Pralsetinib may play a pivotal role in shaping the future of personalized cancer care.

Conclusion

Pralsetinib represents a significant advancement in the treatment of RET-altered cancers, offering a targeted approach that improves patient outcomes while minimizing side effects. Its specific indications for non-small cell lung cancer and medullary thyroid cancer underscore its importance in oncology.

For patients eligible for Pralsetinib, discussing this treatment option with a healthcare provider can provide valuable insights into its benefits and potential role in their cancer management plan. As we continue to uncover the potential of targeted therapies, Pralsetinib stands out as a beacon of hope for many individuals battling cancer. Stay informed about ongoing developments and consider the possibilities that Pralsetinib brings to modern cancer treatment.

Please visit MedChemExpress https://www.medchemexpress.co

[fantasticzombiefire]

York 013-04129-000 Inhibitor 1 Gallon Blue | PartsHnC

York 013-04129-000 is a premixed corrosion inhibitor specifically designed for use in York's heating, ventilation, and air conditioning (HVAC) equipment. This one-gallon solution works by forming a protective layer on metal surfaces within your system, shielding them from harmful corrosion caused by water, oxygen, and other contaminants. This helps prevent leaks, breakdowns, and extends the lifespan of your vital HVAC components

[identifying-cat-phenotypes]

what about my chonker harley? she's a big fluffy girl and i hope these pictures are quality for her 😅

- joey 🍂

This lovely kitty looks like a black smoke!

[amber-tortoiseshell]

is it possible for longhaired smokes to be ghost tabbies? i'd imagine it wouldn't be as striking as it is on shorthaired smokes but like is it possible for a longhair to have prominent enough ghost striping that the average person would look at them and go "yeah that's a tabby"?

I think yeah. Especially on the face, but it's possible on the body too, especially on younger cats: