#hmpv

[nuadox]

AstraZeneca to acquire Icosavax for $1.1B

- By Nuadox Crew -

AstraZeneca is set to acquire Icosavax, a company focused on creating innovative vaccines using a protein virus-like particle platform.

This acquisition aims to enhance AstraZeneca's expertise in preventing respiratory syncytial virus (RSV) by incorporating Icosavax's lead vaccine candidate, IVX-A12, which targets both RSV and human metapneumovirus (hMPV) in adults, especially those with chronic conditions. IVX-A12 has shown promising Phase II results, eliciting robust immune responses against RSV and hMPV, boasting potential advantages over existing RSV vaccines.

The acquisition will also integrate Icosavax's VLP technology, known for mimicking viruses to trigger stronger immune responses, potentially requiring fewer booster shots and offering a lower incidence of side effects compared to current RSV vaccines.

The deal includes financial aspects where AstraZeneca will acquire Icosavax for approximately $0.8 billion upfront, with potential additional payments based on achieving regulatory and sales milestones, totaling around $1.1 billion. This move aligns with AstraZeneca's strategy to address unmet needs in infectious diseases by expanding its portfolio of protective interventions.

The acquisition is subject to certain conditions and regulatory clearances and is expected to close in the first quarter of 2024.

--

Source: AstraZeneca

Read Also

FDA approves first vaccine for pregnant individuals to prevent RSV in infants

[healthywealthysouls]

Human Metapneumovirus (HMPV) - Dangers, Precautions, and Protection

Human metapneumovirus (HMPV) is a respiratory virus that affects people of all age groups. First identified in the Netherlands in 2001, HMPV has gained recognition as a significant cause of respiratory tract infections worldwide. In this article, we will delve into the nature of HMPV, its potential dangers, and essential precautions individuals can take to prevent its spread.

click here to read full article

[politikwatch]

Gefährliches #Virus: Ist das humane Metapneumovirus (#hMPV) Noch existiert kaum eine Behandlungsmethode, geschweige denn eine Impfung. Dennoch sei ein Testen auf das humane Metapneumovirus sinnvoll, findet der Arzt.

[covid-chaos-corruption]

COMMENTS:

mdlstone1959    

No one can trust or believe anything the CDC says. They are liars. Sadly they have destroyed the truth, therefore our trust in them as well. Thanks Jobama for destroying America.

terrygonder   

Here’s another scare tactic from the CDC. Their mRNA vaccine has most likely been the cause of any immunity issues in this country and around the world. If the CDC says something is a problem, they most likely caused it. If they say a vaccine is needed, run the other way.

[health-prohive]

What is human metapneumovirus (HMPV)?

Ans.-

There are most of people don't know about metapneumo virus , and what is cause and symptoms so today we know overall about HMPV

Human metapneumovirus (HMPV) is  discover in 2001,Human metapneumovirus are aspiratory virus that can cause an upper respiratory infection (like a cold) or a lower respiratory infection (like bronchitis or pneumonia). It is most see in children but can also affect adults. Read More

[thejewishlink]

Infections With Little-Known Virus Explode, CDC Warns

A respiratory virus that most people have never heard of was to blame for many hospitalizations and illnesses this spring, health officials say. The human metapneumovirus, or HMPV, causes symptoms similar to COVID-19 or RSV, but doctors don’t usually test for it outside of a hospital setting, meaning many people likely had no idea they had it. The Centers for Disease Control and Prevention…

[ms-hells-bells]

somewhat ill, desperately manifesting for it to disappear overnight, because i already used 3 of my 5 sick days (you go up to 10 gained a year once the first anniversary passes, but the first year is 5) just a couple weeks ago when i caught the HMPV going around.

[delveinsight12]

Bronchiolitis Market: Overview, Causes, Symptoms, Diagnosis, and Treatment

Bronchiolitis is a common respiratory condition primarily affecting infants and young children, characterized by inflammation of the small airways in the lungs (bronchioles). This condition often leads to significant respiratory distress and is a major cause of hospitalization in infants during the winter months. This article provides a comprehensive overview of bronchiolitis, including its causes, symptoms, diagnostic methods, and treatment options.

Bronchiolitis is an acute viral infection that causes inflammation and swelling of the bronchioles, the smallest air passages in the lungs. The condition is most prevalent in children under two years of age and typically occurs in the winter and early spring. Bronchiolitis is usually caused by respiratory syncytial virus (RSV), but other viruses can also be involved. The severity of bronchiolitis can range from mild to severe, with some cases requiring hospitalization.

Causes of Bronchiolitis

The primary cause of bronchiolitis is viral infection, with several key viruses implicated:

1. Respiratory Syncytial Virus (RSV): RSV is the most common cause of bronchiolitis, accounting for the majority of cases. It is highly contagious and spreads through respiratory droplets.

2. Rhinoviruses: These viruses, commonly associated with the common cold, can also cause bronchiolitis, especially in combination with other pathogens.

3. Parainfluenza Viruses: These viruses can contribute to respiratory infections in children, including bronchiolitis.

4. Adenoviruses: Adenoviruses can also cause bronchiolitis, although they are less common than RSV.

5. Human Metapneumovirus (hMPV): This virus can cause respiratory infections similar to those caused by RSV and is increasingly recognized as a cause of bronchiolitis.

Signs and Symptoms

The symptoms of bronchiolitis typically develop within a few days after exposure to a virus and may include:

1. Cough: A persistent cough is a common symptom of bronchiolitis, often accompanied by wheezing and a rattling sound in the chest.

2. Wheezing: The inflammation of the bronchioles causes narrowing of the airways, leading to a wheezing sound during breathing.

3. Respiratory Distress: Infants may show signs of difficulty breathing, including rapid or shallow breathing, nasal flaring, and use of accessory muscles to breathe.

4. Fever: Mild to moderate fever may accompany bronchiolitis, although high fever is less common.

5. Runny or Stuffy Nose: Initial symptoms often include a runny or congested nose, which may progress to more severe respiratory symptoms.

6. Decreased Appetite: Infants with bronchiolitis may have a reduced appetite and difficulty feeding due to respiratory distress.

7. Cyanosis: In severe cases, the skin or lips may turn bluish, indicating inadequate oxygenation and requiring urgent medical attention.

Diagnosis of Bronchiolitis

Diagnosing bronchiolitis involves a combination of clinical evaluation and diagnostic tests:

1. Medical History and Physical Examination: A healthcare provider will assess the patient's medical history and perform a physical examination. Key signs include respiratory distress, wheezing, and abnormal lung sounds.

2. Chest X-Ray: While not always necessary, a chest X-ray can help rule out other conditions such as pneumonia or congenital heart defects. It may show hyperinflation of the lungs or other signs consistent with bronchiolitis.

3. Viral Testing: Diagnostic tests, such as polymerase chain reaction (PCR) or immunofluorescence assays, can identify the specific virus causing the infection. RSV is often confirmed using these methods.

4. Blood Tests: Blood tests may be performed to assess the severity of the infection, check for signs of dehydration, or rule out other conditions.

5. Oxygen Saturation Monitoring: Pulse oximetry is used to measure blood oxygen levels, helping to assess the severity of respiratory distress.

Treatment of Bronchiolitis

Treatment for bronchiolitis focuses on supportive care and alleviating symptoms, as there is no specific antiviral treatment for the condition. Management strategies include:

1. Supportive Care: 

   - Hydration: Ensuring adequate fluid intake is crucial to prevent dehydration, especially if the child is experiencing reduced appetite or difficulty feeding.

   - Nasal Saline Drops: Saline nasal drops or sprays can help relieve nasal congestion and improve breathing.

   - Humidified Air: Using a cool-mist humidifier can help ease respiratory symptoms by keeping the airways moist.

2. Medications:

   - Bronchodilators: Medications such as albuterol may be used to relax the airways and ease wheezing, although their effectiveness in bronchiolitis is debated.

   - Corticosteroids: These are generally not recommended for routine use in bronchiolitis, but they may be prescribed in severe cases or when there is evidence of underlying asthma.

3. Oxygen Therapy: For infants with low oxygen levels, supplemental oxygen may be administered to ensure adequate oxygenation.

4. Hospitalization: In severe cases, hospitalization may be required to provide intensive monitoring and supportive care, including intravenous fluids, respiratory support, and close observation.

5. Preventive Measures:

   - RSV Prophylaxis: In high-risk infants, such as those with congenital heart disease or premature birth, a medication called palivizumab may be given as a preventive measure during RSV season.

Bronchiolitis Market Insights

The market for bronchiolitis treatments reflects the ongoing need for effective management strategies and innovations in respiratory care:

- Market Size and Growth: The global market for bronchiolitis treatments is expanding, driven by the prevalence of respiratory infections in children and the development of new therapeutic and diagnostic solutions. Key segments include pharmaceuticals, diagnostic tools, and supportive care products.

- Key Players: Leading companies involved in the bronchiolitis market include:

   - GlaxoSmithKline: Known for its respiratory therapies and involvement in the development of treatments for respiratory conditions in children.

   - Roche Holdings: Engaged in diagnostics and research related to respiratory infections, including bronchiolitis.

   - AstraZeneca: Focuses on respiratory medicines and has a presence in the market for managing respiratory infections.

   - Novartis Pharmaceuticals: Contributes to research and development in respiratory and infectious disease therapies.

- Research and Development: Ongoing research aims to improve understanding of bronchiolitis, develop new antiviral agents, and enhance supportive care strategies. Innovations in diagnostics and treatments are expected to contribute to better management and outcomes for affected children.

Bronchiolitis is a common and often challenging respiratory condition that affects infants and young children. Understanding its causes, symptoms, and treatment options is crucial for effective management and improved outcomes. With ongoing research and advancements in the field, there is hope for more effective therapies and better preventive measures. The growing market for bronchiolitis treatments highlights the importance of continued innovation and support for managing this prevalent and impactful condition.

Download sample report @ https://www.delveinsight.com/sample-request/bronchiolitis-market

[vibrantgroup9]

OVARIAN CYST

Ovarian cysts are fluid-filled sacs that develop in a woman’s ovaries. While most cysts are harmless and go away on their own, some can cause more serious health issues, especially if left untreated. In some cases, ovarian cysts can be related to certain genes, such as the HMPV gene. Studies have found that certain genetic mutations, like the HMPV gene, may be associated with an increased risk…

[kmp78]

“Nana's smart, she gave him some heavy antibiotics, so he's completely knackered and peacefully snoozing away “. -Nana can’t get anything to give him that a doctor or the like didn’t prescribe. Though I do hope he is sleeping soundly for health’s sake, antibiotics don’t make you sleepy and he called what he has just a “virus” and a “cold”. Antibiotics aren’t properly prescribed for that. (Though I think he’s probably got a little more than a simple, random virus and hMPV or RSV are likely nasty culprits.) Anyway, I think that what ever medications he is taking, I think K’s version of his approach to care is quite possible and probably will work the very best!!! 🤭

Meds are all fine and well, but they won't save his throat/voice if he destroys them. 🤷🏼‍♀️

[decentralvaccine]

Astra Zeneca Agrees To Purchase RSV Vaccine Maker For $1.1B

AstraZeneca said on Tuesday it had agreed to buy respiratory syncytial virus (RSV) vaccine developer Icosavax in a deal valued at up to $1.1 billion.

Icosavax is developing a combination vaccine candidate targeting RSV and human metapneumovirus (hMPV). RSV is a leading cause of pneumonia in toddlers and the elderly, while hMPV causes very similar respiratory tract infections.

The cash deal aimed at bolstering AstraZeneca's drugs pipeline values U.S.-listed Icosavax at $15 a share, plus up to $5 a share if certain milestones are met.

AstraZeneca made its first foray into vaccines by co-developing the COVID-19 shot with Oxford University. It set up a separate vaccine and antibody therapy division in late 2021.

https://finance.yahoo.com/news/1-astrazeneca-buy-rsv-vaccine-071944311.html

[rnomics]

Viruses, Vol. 15, Pages 2272: Human Metapneumovirus-Induced Host #microRNA Expression Impairs the Interferon Response in Macrophages and Epithelial Cells

Human metapneumovirus (HMPV) is a nonsegmented, single-stranded negative #RNA virus and a member of the Pneumoviridae family. During HMPV infection, macrophages play a critical role in defending the respiratory epithelium by secreting large amounts of type I interferon (IFN). Micro#RNAs (#miRNAs) are small, noncoding, single-stranded #RNAs that play an essential role in regulating gene expression during normal cellular homeostasis and disease by binding to specific #mRNAs, thereby regulating at the transcriptional and post-transcriptional levels with a direct impact on the immune response and other cellular processes. However, the role of #miRNAs in macrophages and respiratory viral infections remains largely unknown. Here, we characterized the susceptibility of THP-1-derived macrophages to HMPV infection and the effect of hsa-miR-4634 on these cells. Transfection of an #miRNA mimic and inhibitor demonstrated that hsa-miR-4634 regulates the IFN response in HMPV-infected macrophages, suggesting that HMPV induces the expression of the #miRNA as a subversion mechanism of the antiviral response. This effect was not limited to macrophages, as a similar effect was also observed in epithelial cells. Overall, our results demonstrate that hsa-miR-4634 is an important factor in regulating the IFN response in macrophages and epithelial cells during HMPV infection. https://www.mdpi.com/1999-4915/15/11/2272?utm_source=dlvr.it&utm_medium=tumblr

[mattnicholls69]

What is HMPV, the little-known virus with cases spreading through NSW? - https://www.9news.com.au/national/human-metapneumovirus-hpmv-cases-spiking-in-nsw-what-to-know-updates/1581aa9a-ab4c-44d2-b1da-7cab4ff2cb25