#glp-1 drugs

[andy-tirzepatide]

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[peptidefactory]

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[wausaupilot]

Why millions are trying FDA-authorized alternatives to Big Pharma's weight loss drugs

Compounding pharmacies are producing semaglutide and tirzepatide for hundreds of thousands of patients.

Arthur Allen Illustration by Oona Tempest July 23, 2024 Pharmacist Mark Mikhael has lost 50 pounds over the past 12 months. He no longer has diabetes and finds himself “at my ideal body weight,” with his cholesterol below 200 for the first time in 20 years. “I feel fantastic,” he said.Like millions of others, Mikhael credits the new class of weight loss drugs. But he isn’t using brand-name…

[captainjonnitkessler]

I'm looking up articles on loss of appetite after abdominal surgery, because it's been two weeks and food is still really unappealing to me. And it's all these articles and posts about how it's terrible and they hate it and how long will it be until they go back to normal. But I have binge eating disorder and this is the first time in my life I haven't had a constant undercurrent of craving food - literally any food - and it's fucking incredible. I can make myself eat a small meal when I'm hungry and then I don't think about eating again until I'm hungry again! This is so fucking game changing. RIP to people who hate this but I hope my appetite never comes back.

[xxmolls]

Just a health update (for my own archival records):

My MCAS and allergies got so bad that I literally couldn’t eat anything without horrible allergic reactions. I became fearful of eating at ALL for several weeks and was literally starving, but anytime I ate anything I suffered so much so it wasn’t worth it to me. I’d rather be starving and weak than have to deal with my almost violent severe motor and vocal tics, throat closing, heart racing, heavy weight on my chest, red burning flushing all over my body, mouth sores, nausea, extreme fatigue, muscle and joint pain, etc etc for 3 hours anytime I ate or drank anything.

I was also going into anaphylaxis from random things like anytime I went to the restroom, fragrances of any sort, just sitting on the couch at night, experiencing any strong emotion, crying (which did happen a few times as I was completely fed up), etc

I was going downhill fast again.

Well my MCAS doctor wrote me out of the blue and told me he has been having amazing results with having his patients micro dose glp-1 meds for their MCAS.

(glp-1 meds are like ozempic, wegovy, mounjaro, etc. Known as the diabetes meds celebrities are taking to lose weight)

I was pretty desperate, so I said I wanted to try them.

I did my first shot of a generic glp-1 med last Wednesday… a much much lower dose than people take for diabetes or to lose weight…

I am convinced it’s a miracle drug. Within 10 minutes my severe tics (brought about by anaphylaxis) decreased and calmed down. I sat there just ecstatic to be completely still and give my body a break.

I ate some rice and marinated meat that night (very fearfully) and had no reaction.

I did some restorative yoga that night. Exercise would cause anaphylaxis for me usually… but no reaction.

Throughout the week my brain fog cleared up. My sleep schedule became regular. I was able to eat 3 normal meals a day, adding back in many foods I had previously reacted poorly to.

On Christmas I ate filet mignon, lobster tails, broccoli kugel, and salad. No reaction!

It has been SUCH a relief.

This week I took my 2nd dose and upped it to 9 units (my first dose was 4.5). I’m not doing as well on the 9 units (though still a million times better than before), so I’m going to go back to the 4.5 units dose.

Anyway… I’m very hopeful about the future at again. I feel so much better.

Even if this doesn’t last… I’m so so grateful to just be able to give my body a break from all the severe tics and constant anaphylaxis. Feels like a Christmas miracle.

[medsurfernews]

FDA Approves First Generic Once-Daily GLP-1 Injection for Type 2 Diabetes

The FDA has approved the first generic once-daily GLP-1 injection, liraglutide, to help lower blood sugar in patients with type 2 diabetes. This new generic option aims to improve patient access to affordable diabetes treatments. The U.S. Food and Drug Administration (FDA) has just approved the first generic version of a once-daily injection to help people with type 2 diabetes manage their blood…

[truwellth]

Glp1 For Weight Loss

Get here detailed info on: Glp1 For Weight Loss. Know, Which GLP-1 is Best For Weight Loss? GLP-1 Dosage For Weight Loss. GLP-1 Long-Term Side Effects. GLP-1 Weight Loss Reviews… from Rajashree Gadgil… Top dietitian in Thane… top weight loss nutritionist in Thane, Mumbai & the founder of TruWellth Integrative Health Care… Top dietitian center in Thane, Mumbai.

[pr0cyonid]

Man I'm sorry I keep talking about my weight loss so option, but I just FEEL so much better, both physically and mentally. I saw my parents this weekend and my mom said she can notice a difference. My boyfriend notices a difference. I notice a difference. My friends notice a difference. I don't feel tired all the time and my joints are starting to hurt less.

This has been SO hard for me. I've been trying to lose this weight for years. I've been doing everything right, and it just won't go away - and even my doctors have agreed with me on this. It's so nice to have found something that finally works because it's so gutting to feel like you're putting in all the work to get no results

[andy-tirzepatide]

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[idataacumen]

Glucagon-Like Peptide 1 (GLP-1) Drugs Market Outlook, Trends And Future Opportunities (2024-2031)

Glucagon-Like Peptide 1 (GLP-1) Drugs Market is growing at a CAGR of 12.1% over the next 5 years. Novo Nordisk A/S, Eli Lilly and Company, Sanofi, AstraZeneca, Boehringer Ingelheim, Merck & Co., Inc. are the major companies operating in Glucagon-Like Peptide 1 (GLP-1) Drugs Market

[gsanghamitra]

The Dark Side of Ozempic: Safety Concerns and Online Scams

Diabetes is a metabolic disorder that is a major cause of concern for people in both developing and developed countries. People are now on the lookout for permanent solutions to cure this life-threatening disorder. Scientists have invented many different medications to control diabetes, but often these medications end up being used as a treatment for different disorders. A Denmark-based company,…

[jaydenirish]

Unlock the power of Saxenda Weight Loss Injections at NextMed! 🌟 Say goodbye to excess pounds and hello to a healthier, happier you. Learn more about this transformative solution: 💪🏋️‍♀️

[wellhealthhub]

Diabetes Medicine: An In-depth Guide to Managing Diabetes

Looking for detailed information on diabetes medicine? This extensive article covers all aspects of effective diabetes management, including a wide range of treatments and medications. Gain insights from experts and real-life experiences. Introduction: Recognizing the Vitality of Diabetes Medicine Diabetes, a pervasive chronic condition afflicting millions worldwide, arises from impaired blood…

[medsurfernews]

How GLP-1 RA Drugs Could Help Prevent Epilepsy in Older Adults

Discover how GLP-1 RA drugs, commonly used for diabetes, may help reduce the risk of epilepsy and seizures in older adults. Learn about the latest research findings and their potential impact on neuroprotection.

Discover how GLP-1 RA drugs, commonly used for diabetes, may help reduce the risk of epilepsy and seizures in older adults. Learn about the latest research findings and their potential impact on neuroprotection. Epilepsy is a condition that affects the brain and causes repeated seizures. Seizures are sudden bursts of electrical activity in the brain that can cause changes in behavior, movements,…

[mindblowingscience]

For a long time, dieting and exercise were the only realistic options for many people who wanted to lose weight, but recent pharmaceutical advances have led to the development of weight loss drugs. These are based on natural hormones from the intestine that help control food intake, such as GLP and GIP. GLP-1-based drugs such as semaglutide (Wegovy) and tirzepatide (Mounjaro) work by helping people to feel less hungry. This results in them eating less – leading to weight loss.

Continue Reading.

[macgyvermedical]

can you talk a little about wegovy and muonjaro for weight loss?

The answer is maybe.

If it were just the drugs themselves, I'd say absolutely. But there is a surprising amount of cultural baggage associated with these medications, and I don't really know that I can do them justice.

So first, let's talk about weight. There's a fantastic book called "Fat Talk" by Virginia Sole-Smith, about being overweight or obese in an age that prioritizes thinness, and how diet culture in particular is a threat to young people. Another, called "Intuitive Eating" by Elyse Resch, discusses how calorie restriction- commonly cited as the "way" to lose weight along with exercise- only works once or twice, because our bodies get wise to it and want to hold onto fat.

Humans evolved to gain weight. Fat is how we store energy for times when we might not have enough to eat. And if "not having enough to eat" (whether because of famine or because of calorie restrictive dieting) happens repeatedly, we have evolved to change hormones and metabolism so we a) don't need as much food to stay alive and b) are primed to eat more food than we need when it is available.

Aren't human bodies cool?

In the medical world, there are a lot of things tied to weight. For example, statistically, being overweight or obese means you're more likely to have health conditions like high blood pressure, diabetes, and heart disease. It is unclear, though, if those problems are caused by the weight itself, or other dietary, activity, and behavior patterns that may also happen to contribute to the weight gain. Things like a sedentary lifestyle, frequent consumption of foods with low nutritional value, avoidance of medical care due to stigma, or even chronic calorie restrictive dieting.

Unfortunately, due to this statistical tie, there is a lot of effort made in the medical world to get patients to "lose weight at any cost" instead of recommending dietary, activity, and behavior changes for health reasons alone.

Culturally as well, we prioritize thinness as attractiveness. I remember in high school there was a poster in my health classroom that read "Ideal weight- or it might be hard to get a date!". There are lots of negative associations with people who carry more weight, including that they are lazy or stupid- things that have nothing to do with body size.

Now, that doesn't mean that there aren't things that could be benefits of losing weight. For example, joint and back pain can be improved with weight loss. But weight loss is probably not the end-all be-all cure-all it's touted to be.

Because it is really hard for most people to meet this standard of "lose weight at any cost", there has long been medications that purportedly help people lose weight. Most of these medications have been stimulants, which decrease appetite and make it more comfortable to engage in calorie restrictive dieting. They also increase energy, which can make it easier to exercise or tolerate more exercise than would otherwise be possible.

Before we talk about the drugs, I want to say- there are risks and benefits to all medications, including these! The discussion you should always have is what risks are you and your healthcare provider willing to tolerate for the potential positive outcome. Also, this is a discussion of the drugs when used for weight control. The same drugs used for diabetes are at different dosages and have potentially different risk/benefit comparisons.

Ozempic/Wegovy (semaglutide) and Mounjaro/Zepbound (tirzepatide) are both a type of medication called a GLP-1 agonist. GLP-1 agonists are also called incretin mimics, because they mimic a type of hormone (incretin) that tells the brain and body that it is full. This makes it easier to eat a small amount of high nutrition food and feel satisfied. They also work by increasing metabolism. Between the decreased consumption and the increased metabolism, weight is lost.

Over the course of a year and a half, tirzepatide causes about 15-20% average reduction in body weight with continued use. Over the course of about the same time, semaglutide causes an average of about 15% body weight reduction with continuous use. Say, for example, you weigh 100kg. A year and a half on one of these medications could get you down to 85kg.

The problem is, as soon as that drug is withdrawn, the body realizes it was starving, and tries to compensate. These drugs are good at getting rid of weight, but maintaining a new weight usually means staying on a lower dose of the drug perpetually. Most people regain all weight (and potentially more than they lost) within 5 years of stopping the drugs.

Some studies suggest that repeatedly regaining lost weight may be more detrimental to health than remaining overweight or obese when it comes to statistical risk of type 2 diabetes, heart disease, and other "weight-associated" illnesses.

The main side effects are GI-related. Most of these are nausea, vomiting, diarrhea, gas/bloating, constipation, dizziness, and abdominal pain. More severe side effects include pancreatitis (inflammation of the pancreas) and gasteroparesis (paralysis of the stomach and part of the digestive tract).