#from the public

[new-berry]

Oh no the tragic moment when you read what you have written and spiral from genius to tragic without blinking.

Sugar and rediscovering my ego will help with this.

[twinliches]

shoutout to the guy who after unsuccessfully hitting on my sister and being politely declined asked her "is it okay if i ask your brother instead" and when she said yes gave me a long and searching look before sighing and going "no. i am not drunk enough to go for a dude. but you look like an angel" happy bisexual pride to this man and this man only. hope you figure it out soon king

[tauforged]

WE HAVE A PEACOCK MANTIS SHRIMP AT WORK NOW AND I AM OBSESSED WITH HER. EVERYONE SAY HI TO SCYLLA!! PLEASE ADMIRE HER BEAUTIFUL COLORS AND SASSY LITTLE GRAVEL KICK. SHES INCREDIBLE

[stitchthesewords]

its rude to reblog things from people you arent mutuals with fyi. :/

💀 my brother in christopher

[randanopterix]

Luffy gets some new kicks

[alternativeulster]

dont let anyone ever tell you the doctor who tv movie (1996) sucks. this is literally the best scene in all 60 years of doctor who

[satanicdollx]

they should invent friends that do not live so fucking far

[july-19th-club]

seriously have been thinking about this all night long. call me autistic but the fact that 90% of workplaces the point is not to get your work done and then be done doing it but to instead perform an elaborate social dance in which you find something to do even when you're done doing everything you need to do in order to show your fellow workers that you, too, are Working . because you are at Work . disgusting why cant we all agree that if there is no work immediately to be done. we just dont do anything

[reasonsforhope]

A new treatment combining ReCET and semaglutide could eliminate the need for insulin in type 2 diabetes, with 86% of participants in a study no longer requiring insulin therapy. The treatment was safe and well-tolerated, and further trials are planned to confirm these results.

Groundbreaking research presented at UEG Week 2024 introduces a promising new treatment approach for type 2 diabetes (T2D) that has the potential to greatly reduce or even eliminate the need for insulin therapy.

This innovative approach, which combines a novel procedure known as ReCET (Re-Cellularization via Electroporation Therapy) with semaglutide, resulted in the elimination of insulin therapy for 86% of patients.

Globally, T2D affects 422 million people... While insulin therapy is commonly used to manage blood sugar levels in T2D patients, it can result in side effects... and further complicate diabetes management. [Note: Also very importantly it's fucking bankrupting people who need it!!] A need therefore exists for alternative treatment strategies.

Study Design and Outcomes

The first-in-human study included 14 participants aged 28 to 75 years, with body mass indices ranging from 24 to 40 kg/m². Each participant underwent the ReCET procedure under deep sedation, a treatment intended to improve the body’s sensitivity to its own insulin. Following the procedure, participants adhered to a two-week isocaloric liquid diet, after which semaglutide was gradually titrated up to 1mg/week.

Remarkably, at the 6- and 12-month follow-up, 86% of participants (12 out of 14) no longer required insulin therapy, and this success continued through the 24-month follow-up. In these cases, all patients maintained glycaemic control, with HbA1c levels remaining below 7.5%.

Tolerability and Safety

The maximum dose of semaglutide was well-tolerated by 93% of participants, one individual could not increase to the maximum dose due to nausea. All patients successfully completed the ReCET procedure, and no serious adverse effects were reported.

Dr Celine Busch, lead author of the study, commented, “These findings are very encouraging, suggesting that ReCET is a safe and feasible procedure that, when combined with semaglutide, can effectively eliminate the need for insulin therapy.”

“Unlike drug therapy, which requires daily medication adherence, ReCET is compliance-free [meaning: you don't have to take it every day], addressing the critical issue of ongoing patient adherence in the management of T2D. In addition, the treatment is disease-modifying: it improves the patient’s sensitivity to their own (endogenous) insulin, tackling the root cause of the disease, as opposed to currently available drug therapies, that are at best disease-controlling.”

Looking ahead, the researchers plan to conduct larger randomized controlled trials to further validate these findings. Dr. Busch added, “We are currently conducting the EMINENT-2 trial with the same inclusion and exclusion criteria and administration of semaglutide, but with either a sham procedure or ReCET. This study will also include mechanistic assessments to evaluate the underlying mechanism of ReCET.”

-via SciTechDaily, October 17, 2024

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Note: If it works even half as well as suggested, this could free so many people from the burden of the ongoing ridiculous cost of insulin. Pharma companies that make insulin can go choke (hopefully).

[lazylittledragon]

y'know every time i feel guilty about bothering someone by singing along when i'm listening to music, i just remember that i have to tolerate my dirtbag brother screaming at his ps5 for hours every day so listening to muffled off-key fall out boy is probably preferable

[mythicalcoolkid]

You don't wish your disability was worse or more visible, you wish your disability was taken seriously. Please stop confusing the two, I guarantee you would not get the support you need JUST by being more severe or more visible. Please listen to visibly disabled people when we tell you it isn't better on our side

[rayveneyed]

sukuna ryomen is somewhat of an infamous bachelor.

it’s not surprising to see him with a new beau every few months, if not weeks — almost trope-like in their frequency, his image bouncing between playboy and manwhore. he doesn’t take it personally, and he makes sure to let people know: he’s young and sexy and he has two oscars, for fuck’s sake, so he thinks the world can cut him some slack when he wants to mess around. and mess around he does.

between obvious paparazzi shots of panties tucked badly into his back pocket, and instagram posts with fellow actors and models pressed tightly against his chest, most are divided between thinking it’s either damn good pr, or a simple man living a life most would wish for. regardless, nobody is surprised when sukuna arrives alone at the mugler show for paris fashion week, and leaves with someone on his arm.

the only thing that came as a bolt from the blue was that it was you hanging from him.

the photos are undeniable, a story in parts; sukuna finding his seat in the front row, you on one side and kendall jenner on his other. his eyes drifting from the models to your face, as if taking a clandestine peek. you, meeting his underhanded gaze with a smile as sweet as spun sugar — and, gasp, sukuna returning it. the display is so out of character for him it feels almost voyeuristic to see it plastered all over twitter.

you, with your vintage, girl-next-door-esque image, big hair and big eyes and demure, calf-length hems, a voice that evokes the memory of helen forrest or ella fitzgerald. him, with his smudged eyeliner and tattoos and all-black attire, persistently typecasted as the panty-dropping bad-boy or devil-smiled brute. it shouldn’t work. for all intents and purposes, he should be spotted with a new supermodel the next week, leaving you in the dust of his philandering. most expect it, wait for the other boot to drop — expect an album of heartbreak from you, but—

a month passes. and another, and another. and suddenly sukuna ryomen, notorious rake, is photographed backstage at your shows. suddenly there’s an anklet hanging from your ankle, his initials in garnet. it’s early morning paparazzi pictures of you both in sweatpants and hoodies — yours, suspiciously oversized — one of his hands engulfing yours, the other holding a bag of takeout from a local breakfast spot, a lit cigarette in his mouth. hickies on your neck and a shit-eating grin on sukuna’s face. candid snaps taken at intimately sized parties, with his chin hooked over your shoulder and his large hands cupping your stomach. tiktoks of you both on the red carpet in the background of somebody else’s interview, sukuna leaning in close to brush an eyelash from your cheek.

neither of you confirm anything, but then — you don’t need to, do you?

[kaiserin-erzsebet]

Coining a phrase: Period atypical homophobia.

Definition: When the writer of a piece of historical fiction hasn't really bothered to research how gay people existed in a period of time or what terms would have been used to discuss homosexuality positively or negatively. So instead they put the most modern, likely religious terms into the mouth of a historical character to establish that a character is homophobic.

e.g. Having every Victorian character be a religious homophobe instead of having them talk about "public decency" and "discretion"

[pixelpolls]

Vamps vs Werewolfs like its 2010!