#fisetin side effects

[flowforcemaxhealth]

FlowForce Max Reviews ((🚨🚫Fake or LEGIT🚫🚨)) Serious Customer Complaints Warning!

The goal of the male health supplement FlowForce Max is to maximize prostate health. It is a blend of specific plants and minerals that have been shown to promote prostate health. Specific plant nutrients in the solution improve men's energy levels, lower inflammation, and improve urine functions.

The research team that created the concoction claims that a single potent herbal remedy can address a variety of prostate health issues. FlowForce Max Check out the FlowForce Max review to see if these assertions are true!

What Is The Max FlowForce?

FlowForce Max is a natural male product that helps individuals with enlarged prostates improve their ability to urinate and control their inflammatory responses. The official website states that the pill is made with 18 nutrients that assist prostate health in order to support male health and nourish prostate cells.

It is stated that a certain combination of plant extracts can treat various prostate problems naturally and without causing any negative side effects. The solution not only treats prostate issues but also increases libido, energy, and vitality. If your prostate health is deteriorating and you are concerned, FlowForce Max is a possible remedy.

The prostate gland is prone to inflammation associated with aging. Toxicological exposure from the environment in excess is another significant factor in the situations. Prostate cancer is not a frequent ailment, but in older men, worsening symptoms might result in conditions such as benign prostatic hyperplasia. Supplementing with antioxidants may aid in lowering oxidative stress in the prostate area.

But only when every aspect of male wellness is taken care of can a holistic approach be implemented. With its all-herbal formula, FlowForce Max can address any aspect of prostate health, including erectile dysfunction, sexual health, energy, blood circulation, endurance, and more.

A month's worth of FlowForce Max, a nutritional supplement in capsule form, is sold in bottles. The capsule is made to fit a variety of body types and age groups. The manufacturers state that the herbal combination is encapsulated in GMP-compliant, FDA-registered production facilities located in the United States.

Additionally, there are no GMOs, chemicals, stimulants, or preservatives in the mix. FlowForce Max Reviews The tablet is appropriate for a wide range of users due to the lack of common allergies.

An Extensive Examination Of The Components In FlowForce Max

FlowForce Max is purported to have an optimally balanced blend of antioxidants, vitamins, minerals, and herbal extracts. Every component of FlowForce Max has undergone clinical testing to ensure that it is safe, well-tolerated, and efficacious in treating prostate issues.

Let's look at the functions of a few of the formula's components.

Research has shown that Graminex flower pollen extract is effective in treating urinary tract dysfunctions and shrinking enlarged prostate glands. The component has been shown in numerous studies to support the maintenance of normal prostate function. According to research, pollen from flowers may help stop the formation of prostate cancer cells.

Luteolin: For a very long time, Chinese traditional medicine has used luteolin to treat ailments like cancer and inflammation. The ingredient has been shown in numerous tests to slow the growth of prostate tumors. This FlowForce Max component has been shown in numerous clinical investigations to possess antiviral, neuroprotective, cardioprotective, antioxidant, and antibacterial qualities.

Prostate cancer has been found to be resistant to the anticancer effects of grape seed extract. It has an abundance of vitamins and antioxidants that can protect the prostate cells from oxidative damage, lower inflammation, and nourish the prostate cells. High blood pressure can be effectively lowered by eating grape seeds.

Fisetin: Studies have shown that Fisetin helps stop the spread of prostate cancer. Furthermore, it possesses anti-inflammatory qualities that can lessen tissue inflammation in the prostate. Fisetin lowers the risk of cardiovascular diseases, according to studies. Additionally, it has been discovered that the chemical benefits the intestinal microbiota.

Monolaurin: Research suggests that monolaurin may be able to fight infections and somewhat lessen inflammation. It is well known that monolaurin has immune-boosting qualities. Additionally, some research suggests that this FlowForce Max Prostate Supplement component may prevent the storage of fat.

How Does FlowForce Max Encourage Outcomes?

Peer-reviewed studies and a wealth of scientific research support FlowForce Max, demonstrating the potential of the herbal extracts in the recipe to support prostate health at its best. Each component of the mixture has a major impact on reducing inflammation, promoting easy urination, and preventing prostasis.

Because of the supplement's antibacterial qualities, illnesses to the bladder and urinary system are prevented. It serves as a multipurpose remedy that improves male reproductive health, increases sexual arousal, and lessens problems associated with the prostate.

Prostate health issues are addressed at their source with FlowForce Max. According to recent research, age-related hormonal changes and the buildup of pollutants can cause inflammation and harm to prostate cells.

Premium plant nutrients that have been shown in several studies to support immune system health, fight free radicals, and aid in detoxification are used in the creation of FlowForce Max. Blood vessel strength and purification are achieved, enabling optimal blood flow throughout the body. This promotes healthy erectile functions and nourishment delivery.

Components with anti-inflammatory properties reduce the enlarged prostate to the proper size. The prostate cells are nourished and the mending process is carried out by vitamins, minerals, and antioxidants. Tissues and cells are free of inflammatory cells and poisons and function properly. Optimal urine functions are restored in the urinary tract system.

Advantages Of FlowForce Max Capsule Ingestion

A combination of advantageous herbal extracts that have been clinically shown to provide users with several health benefits is called FlowForce Max. The dietary supplement not only supports prostate health but also enhances general male health.

The following are the main benefits of use FlowForce Max capsules.

Encourage prostate health: The mixture works to calm inflammation, get rid of pollutants, feed prostate cells, and make the prostate feel better.

Enhance bladder functions: The formula's nutrients help the prostate gland grow back to its natural size, relieve strain on the bladder, and promote easy urination.

Fights oxidative damage: Using antioxidant chemicals, FlowForce Max treats prostate inflammation and age-related oxidative stress.

Increase stamina: The pill relieves exhaustion and increases vigor and stamina.

Boost sexual well-being: The blend's beneficial elements increase libido, sexual arousal, and performance.

Pros And Cons of FlowForce Max Male Health Supplement

Without a thorough analysis of a health supplement's benefits and drawbacks, we cannot be sure of its veracity. Let's examine FlowForce Max's merits and drawbacks in order to determine its credibility.

pros of Air Force Max

natural components

formula supported by science

Good client service

produced in a US facility with FDA and GMP certifications.

Preservatives, additives, stimulants, and GMOs are all absent.

Not creating a habit

Soft candies that are chewable

60-day return policy for money

Freebies when you buy many months at a time

cons to FlowForce Max

exclusively available for purchase on the official FlowForce Max website

Users may experience different results.

How Can FlowForce Max Pills Be Used to Get Better Outcomes?

Bottles containing thirty servings of the capsulated general health supplement FlowForce Max are available. For best effects, one chewable soft candy should be consumed each day, according to the official website.The manufacturer strongly encourages adhering to dose guidelines and maintaining regular use. Before using the FlowForce Max pill, customers who are receiving medical treatment or have been diagnosed with a medical condition should speak with their doctor.

Is Using FlowForce Max Safe?

Let's assess the supplement's safety to see if it is gentle and safe for the body. According to official reports, FlowForce Max is made entirely of natural substances that are regularly checked for purity and safety. Good customer reviews, production guidelines, and quality certifications all contribute to the perception that the supplement is reliable and authentic.

The FDA routinely inspects the production facilities where FlowForce Max is made, according to the official website. This guarantees that the product meets the US government's quality and safety standards.

GMP-compliant standard manufacturing procedures are used in the formulation of FlowForce Max. Additionally, the producers have declared that there are no traces of synthetic materials, genetically modified organisms, stimulants, or fillers in the mix.

The components of FlowForce Max are collected from nearby farmers and examined for pollutants and poisons. Moreover, it doesn't include any common allergens. Users of the formula have not reported experiencing any severe negative effects. Before using, consumers should see a professional and look for any substances that may cause allergies on the label.

How Much Time Does Flowforce Max Take To Produce Results?

Natural supplements typically show results over time. The body requires time to absorb and activate the natural nutrients. Reviews of FlowForce Max indicate that after two to four weeks of consistent use, users saw noticeable results.

The supplement showed its greatest effects when used consistently for a minimum of three months. This time range, however, is likely to change depending on the users' genetics, age, and physical circumstances.

Customer Reviews and Complaints about FlowForce Max

Verified customer reviews will provide us insight into the opinions of consumers regarding dietary supplements. Several clients have posted their answers on various websites. after an analysis of customer reviews for FlowForce Max. It was discovered that most of them have favorable aspects.

Numerous clients have attested to and commended the formula's efficacy in resolving typical prostate problems and improving general male reproductive health. After utilizing FlowForce Max for one month, users report improved intimate performance, higher endurance, and smoother urine functions.

While individual user experiences appear to differ, all clients eventually claim to have noticed a noticeable improvement over time.

What Store Sells FlowForce Max? Cost And Refund Guidelines

FlowForce Max is exclusively available for purchase on the product's official website. There are no other retail or e-commerce sites that carry it. The maker has issued a warning regarding counterfeit goods, which have been widely publicized.

Consequently, it is recommended that you only buy from authorized distributors in order to guarantee that the goods you receive is genuine.

FlowForce Max is presently available for purchase on their official website at a discounted price. It is available in the following three bundles for purchase:

$30 for a 30-day supply of one bottle plus free shipping

Three bottles (a ninety-day supply) for $59 plus free shipping and two free ebooks

180-day supply of 6 bottles for $59 plus free shipping and two free ebooks

There is a 60-day money-back guarantee on FlowForce Max. In any event, the policy guarantees total customer pleasure and suggests that the goods is legitimate. Customers have 60 days from the date of purchase to contact customer care and get a complete refund if they do not receive the promised benefits.

Official Page: https://www.mid-day.com/lifestyle/infotainment/article/flowforce-max-review-flow-force-max-official-insights-and-customer-warning-23344096

Bonuses Included With Flowforce Max

You can get two free bonuses when you buy the FlowForce Max 3- or 6-month bundle. These educational digital tutorials will help you get the most out of your FlowForce Max experience.

The bonuses are described as follows in brief:

The 5-Day Kidney Home Detox is Bonus No. 1.

Rejuvenating your kidneys doesn't have to be costly or time-consuming. A few everyday activities that can help cleanse and optimize the functions of your kidneys are introduced in this digital handbook.

Bonus 2: 7-Day On-Demand Erections

Sometimes treating erectile dysfunctions in daily life just requires using a few basic measures. Your physique, erection, and stamina can all benefit from this.

Conclusion Regarding Flowforce Max Reviews

Following a close examination of FlowForce Max, the real results suggest that this prostate health supplement is real and not a fraud. The supplement includes scientifically validated herbal compounds that have been shown to improve prostate health, according to scientific references. The scientific procedures, established health benefits, possible risk factors, and other details have been clarified by the FlowForce Max review.

Data from reliable sources indicates that FlowForce Max works well to improve urogenital function, physical performance, and endurance. Additionally, consumer reviews are consistent with what the maker says it is, thus it is real. For people who want to improve their prostate health and increase their vitality and mainlines, FlowForce Max is a reliable option.

[flowforcemaxsite]

FlowForce Max-Results, Side Effects & Consumer Feedback!

FlowForce Max, an improvement claiming to help prostate prosperity, has emerged in the market as a potential solution for individuals grappling with prostate-related issues. With responsibilities of chipped away at urinary ability, reduced disturbance, and overall prostate wellbeing, this supplement means to address typical concerns among men.

Be that as it may, in the midst of the plenty of wellbeing items flooding the market, distrust emerges with respect to the viability and credibility of FlowForce Max. This examination intends to dive into the arrangement, logical proof, client encounters, and by and large standing of FlowForce Max to decide if it truly follows through on its cases or on the other hand assuming it possibly falls into the classification of misdirecting wellbeing supplements.

😍🎁👉𝑺𝒑𝒆𝒄𝒊𝒂𝒍 𝑶𝒇𝒇𝒆𝒓- 𝑭𝒓𝒆𝒆 𝑺𝒉𝒊𝒑𝒑𝒊𝒏𝒈 𝑻𝒐𝒅𝒂𝒚🎁😍👇

https://supplementcarts.com/flowforce-max-official-page/

What Is FlowForce Max?

Stream Power Max is a general wellbeing supplement that can treat your prostate issues normally by utilizing an exclusive mix of plants and minerals. The FlowForce Max male wellbeing support recipe should take care of your prostate medical issues. Created in FDA-supported, GMP-confirmed offices, each container of this nourishing enhancement accompanies 30 tablets. In this way, on the off chance that you adhere to the guidelines given by the makers, each container will last you for an entire month. Moreover, it additionally claims to be an all-regular, sans gmo supplement.

These are a portion of the cases the makers of FlowForce Max prostate wellbeing supplements provide for their clients. In any case, does the item fulfill the previously mentioned claims in general? In the forthcoming areas of this FlowForce Max audit, I will confirm the credibility of every one of these cases utilizing the accessible data.

Ingredients Present In The FlowForce Max Formula

In view of the data gave on the authority FlowForce Max site, this regular male equation contains an impeccably dosed restrictive mix of chosen plants and minerals. The mix of normal fixings present in this dietary enhancement will deal with your prostate issue easily.

The FlowForce Max fixings are recorded beneath:

Graminex Flower Pollen Extract: Graminex flower pollen extract is a mixture of standardized pollen from ryegrass, corn, and timothy. This natural product can efficiently treat conditions like prostatitis, commonly known as prostate inflammation.

Fisetin: Fisetin is a plant flavonoid that is known for its antioxidant properties. As it prevents the accumulation of amyloid beta, it can fight against bladder and prostate cancer.

Luteolin: Luteolin is a group of naturally occurring compounds known for their antioxidant and anti-inflammatory properties. It can inhibit the growth of prostate tumors.

Monolaurin: Monolaurin is a chemical derived from lauric acid, commonly found in breast milk and coconut fat. This FlowForce Max ingredient is known for its antifungal properties.

Oregano leaf extract: Oregano leaf is a popular antioxidant known for its antibacterial and antiviral properties. It can kill cancer cells, thereby preventing you from suffering from prostate cancer.

Grape seed extract: Grape seed extract, made with the seeds of wine grapes, is rich in antioxidants. This FlowForce Max ingredient can regulate androgen receptor-mediated transcription in prostate cancer cells, thereby inhibiting the growth of prostate cancer.

Other FlowForce Max ingredients are: saw palmetto, Vinitrox, Muira puama extract, tricalcium phosphate, peppermint leaf extract, sucrose, magnesium stearate powder, silk protein extract, perilla leaf extract, etc.

How FlowForce Max Works

The restrictive mix of FlowForce Max, delivered utilizing regular and drug grade fixings, should assist you with accomplishing ideal prostate wellbeing. In view of the data accessible on the authority site of this endurance and strength promoter, each FlowForce Max fixing assumes a critical part in advancing the wellbeing of one's prostate.

The FlowForce Max cases give prostate wellbeing as well as work on male drive and further battle against prostatitis. It can obliterate in excess of 40 types of Candida, a types of microbe that causes shallow and fundamental parasitic diseases in people.

Moreover, the makers additionally guarantee that the gainful fixings present in the FlowForce Max prostate-supporting equation will give you moment alleviation, as Vinitrox will rapidly convey the fixings to your urinary lot. This is the manner by which FlowForce Max works inside your body to safeguard and keep up with your prostate wellbeing. Presently, how about we further confirm the legitimacy of this enhancement by deductively checking the effectiveness of its fixings.

✅𝐎𝐟𝐟𝐢𝐜𝐢𝐚𝐥 𝐖𝐞𝐛𝐬𝐢𝐭𝐞✅ 💲 𝐁𝐞𝐬𝐭 𝐏𝐫𝐢𝐜𝐞👉 https//flowforcemax.com

Scientific Research Behind FlowForce Max

Prior to putting resources into an item, particularly a wellbeing related supplement, one ought to investigate the logical exploration that backs it to decide its validness.

A recent report, "A Basic Survey of Graminex Bloom Dust Concentrate for Suggestive Help of Lower Urinary Lot Side effects (LUTS) in Men" and a recent report, "The Job of Blossom Dust Concentrate in Overseeing Patients Impacted by Persistent Prostatitis/Ongoing Pelvic Torment Syndrom" demonstrate the significant job Graminex bloom dust separate plays in lessening the irksome side effects and torment of people experiencing constant prostatitis.

One more 2015 review distributed in the Public Library of Medication, "Movement of polyphenolic compounds against candida glabrata," determines the job the cancer prevention agent properties of polyphenolic intensifies like flavonoids play in lessening the capability of obtrusive candidiasis like C.glabrata. A recent report, "In Vitro Impacts of Monolaurin Mixtures on Encompassed RNA and DNA infections," demonstrates the job monolaurin plays in eliminating the infectivity of infections, including the ones that will hurt one's prostate wellbeing.

One more review distributed in the Public Library of Medication in 2016, "Fisetin as a promising antifungal specialist against Cryptococcus neoformans species complex," demonstrates that part fisetin can restrain the development of growths. Moreover, a recent report, "Persistent prostatitis/ongoing pelvic torment condition: the job of an antifungal routine," demonstrates the way that one can decrease the side effects of prostatitis by following an antifungal routine.

In this way, so, as the majority of the FlowForce Max fixings are antifungal, one will actually want to battle against prostatitis. Besides, by adding fixings that will help male conceptive wellbeing, as muira puama separate, this male wellbeing support equation goes about as a general wellbeing supplement.

Benefits Of FlowForce Max Male Health Supplement

The advantageous fixings added to the strong FlowForce Max prostate help recipe should give a few advantages to the clients. How about we take a gander at a portion of the advantages these fixings can practically give.

Boosts male reproductive health: FlowForce Max ingredients like Silk protein powder, Magnesium stearate powder, Saw palmetto fruit extract powder, Monolaurin, Graminex flower pollen extract, etc., can support and boost male reproductive health.

Can prevent prostate cancer: The Perilla leaf extract, Peppermint leaf extract, Grape Seed extract, Oregano Leaf extract, Luteolin, etc., included in this stamina and health booster, can prevent or reduce the impact of prostate cancer.

Boosts male health: FlowForce Max ingredients like Muira puama extract, ViNitrox, Saw palmetto fruit extract powder, Grape seed, Fisetin, etc., can increase male health.

Advantages And Limitations Of FlowForce Max

One might feel that on the grounds that an item is created utilizing great fixings under sterile assembling conditions, it will be totally drained of cons. Yet, that isn't accurate. Each item, independent of how impeccably delivered, will have a few cons joined to it. Thus, prior to getting it, one ought to know about the cons they can anticipate from this item to decide if it merits the cost.

The FlowForce Max upsides and downsides are recorded underneath:

Pros Of FlowForce Max

Created solely utilizing regular fixings.

The FlowForce Max sexual wellbeing recipe contains no GMO fixings.

Created in FDA-supported, GMP-ensured offices.

Will get two rewards worth $109 free of charge with explicit orders.

Accompanies a 60-day unconditional promise.

Cons Of FlowForce Max

The time taken for FlowForce Max to deliver results will vary for every person.

The legitimate item must be bought through the FlowForce Max official site.

😍🎁👉𝑺𝒑𝒆𝒄𝒊𝒂𝒍 𝑶𝒇𝒇𝒆𝒓- 𝑭𝒓𝒆𝒆 𝑺𝒉𝒊𝒑𝒑𝒊𝒏𝒈 𝑻𝒐𝒅𝒂𝒚🎁😍👇

https://supplementcarts.com/flowforce-max-official-page/

FlowForce Max: Dosage Instructions

Regardless of how gainful a dietary enhancement is, on the off chance that it isn't utilized as expected adhering to the guidelines set by the makers, it can not create palatable outcomes. In this way, to encounter ideal FlowForce Max results, you need to take it reliably in the trained way.

In light of the data gave on the enhancement name, you just need to take one FlowForce Max tablet reliably prior to nodding off. In a perfect world, the client is supposed to bite the tablet and let it liquefy totally in their mouth as opposed to gulping it. It will assist one with encountering ideal advantages from this enhancement.

Is FlowForce Max Formula Safe For You?

Wellbeing is quite possibly of the main boundary one needs to consider prior to buying a wholesome enhancement. Thus, I analyzed all the FlowForce Max client audits accessible to decide if this male wellbeing support is protected to utilize. Until now, none of the FlowForce Max audits have detailed any secondary effects subsequent to utilizing the enhancement.

As per the makers, the FlowForce Max dietary enhancement is exclusively produced using regular fixings and delivered in FDA-supported GMP-affirmed offices, it shouldn't create any significant secondary effects. Thus, in view of the audits made by FlowForce clients till now, this male wellbeing support is protected to utilize.

Customer Reviews: What Real Users Say About FlowForce Max

I went through each FlowForce Max client survey to comprehend the clients' opinion on this male wellbeing support recipe. The greater part of the clients have left a positive survey for this enhancement. They appear to be very happy with this prostate wellbeing equation.

Many have remarked about the palatable outcomes they got to encounter by utilizing it reliably. All the more critically, until now, none of the clients have recorded an objection against it. A portion of the clients were marginally disappointed with how much time took to deliver results.

In any case, as variables like body supporters, exactness of taking theFlowForce Max tablets, and so forth, additionally impact the time taken to create results, one can't blame the equation alone. Thus, as a rule, one can express that a larger part of FlowForce clients have figured out how to obtain good outcomes from this prostate wellbeing recipe.

Price Details Of Different FlowForce Max Supplement Packages

To keep clients from coincidentally buying copies, the producers straightforwardly sell the legitimate enhancement through the authority FlowForce Max site. It is made accessible as three groups.\

1 bottle (30-day supply) = $69

3 bottles (90-day supply) = $177 ($59 for each)

6 bottles (180-day supply) = $294 ($59 for each)

The producer likewise offers a 60-day unconditional promise for the clients. In this way, in the event that you by chance weren't dazzled with the FlowForce Max male wellbeing equation, you can continuously return it in something like 60 days from the date of procurement and benefit 100 percent discount.

✅𝐎𝐟𝐟𝐢𝐜𝐢𝐚𝐥 𝐖𝐞𝐛𝐬𝐢𝐭𝐞✅ 💲 𝐁𝐞𝐬𝐭 𝐏𝐫𝐢𝐜𝐞👉 https//flowforcemax.com

Final Take On FlowForce Max Reviews

Upon intensive assessment of FlowForce Max, the proof recommends that this prostate wellbeing supplement isn't a trick. The enhancement's plan seems, by all accounts, to be founded on experimentally upheld fixings known for their possible advantages in supporting prostate wellbeing. Fixings, for example, saw palmetto, beta-sitosterol, and lycopene have been related with positive results in prostate-related issues, and their presence in FlowForce Max lines up with laid out research.

Furthermore, client tributes and surveys convey positive encounters, with people announcing enhancements in urinary capability and in general prostate prosperity. The straightforward correspondence of the enhancement's fixings and the shortfall of huge warnings add to the general impression that FlowForce Max is a real item intended to address prostate wellbeing concerns.

As of the ongoing evaluation, FlowForce Max has all the earmarks of being a trustworthy choice for those looking for prostate wellbeing support, and its standing is demonstrative of a veritable work to follow through on its commitments instead of being a misleading wellbeing trick.

More Relative Blogs

[mcushing7]

The Reasons Everyone Needs Organic Fisetin For Bra Health & More!

The Reasons Everyone Needs Organic Fisetin For Bra Health & More!

If you visit my site often, then you know I am all about natural remedies and supplements to ensure that I am staying healthy and strong. I would much rather stay healthy and strong using all natural remedies versus taking the medications that the doctors prescribe to you. Medications prescribed by your doctor can have side effects that are worse most of the time, than what brought you into the…

[wisepowder]

Pure Fisetin Powder: A Dietary Antioxidant In Aging and Longevity

Fisetin is a common botanical polyphenol and flavonoid found in a wide variety of plants, fruits and vegetables including strawberries, apples, persimmons, onions and cucumbers. Fisetin is considered a plant pigment imparting many fruits and vegetables, such as strawberries, with their characteristic color and appearance. Fisetin has a very similar molecular structure as the more popular plant flavonoid and dietary supplement Quercetin. Unlike Quercetin, however, Fisetin may be a senolytic and perhaps one of the most powerful senolytics known.

Manufacture: Batch Production

Package: 1KG/bag, 25KG/drum

1.What is Fisetin?

2.The Mechanism Of Action of Fisetin: How does Fisetin work?

3.What food contains Fisetin?

4.What are the benefits of Fisetin?

5.Fisetin Vs Quercetin: is fisetin the same as quercetin?

6.Fisetin Vs Resveratrol: is fisetin better than resveratrol?

7.Fisetin and weight loss

8.How much fisetin should I take: The fisetin dosage?

9.What are the side effects of fisetin?

10.Fisetin powder and fisetin supplements online

Fisetin Chemical Base Information Base Information

Name: Fisetin Powder

CAS: 528-48-3

Purity: 65%，98%

Chemical name: 2-(3,4-Dihydroxyphenyl)-3,7-dihydroxy-4H-1-benzopyran-4-one

Synonyms: 2-(3,4-dihydroxyphenyl)-3,7-dihydroxychromen-4-one , 3,3′,4′,7-Tetrahydroxyflavone ,5-Deoxyquercetin , Natural Brown 1 , CI-75620 , NSC 407010 , NSC 656275 , BRN 0292829 ,

Cotinin , 528-48-3 (anhydrous)

Molecular Formula: C15H10O6

Molecular Weight: 286.24

Melting Point: 330° C (dec.)

InChI Key: GYHFUROKCOMWNQ-UHFFFAOYSA-N

Form: Solid

Appearance: Yellow Powder

Half Life: /

Solubility: Soluble to 100 mM in DMSO and to 10 mM in ethanol

Storage Condition: −20°C for long time

Application: Fisetin is a potent sirtuin activating compound (STAC), antiinflammatory and anticancer agent

Testing Document: Available

Flavonoid polyphenols are commonly used for their antioxidant properties. Their main source is fruits and vegetables that are consumed regularly, by

millions worldwide. Due to their health benefits, flavonoids have also become key ingredients in different dietary supplements, especially resveratrol.

Recent studies have found a new flavonoid namely fisetin, which is believed to be the most potent among the other flavonoids used as a dietary

supplement. Fisetin powder or Fisetin supplements have since increased in demand due to their health benefits.

What is Fisetin?

Fisetin is a flavonoid polyphenol that acts as a yellow pigment in plants. Originally discovered in 1891, fisetin is found in many fruits and vegetables such

as persimmon and strawberries. Although it has been around for a long time, it was only recently that the fisetin benefits were discovered and made it

stand out compared to other supplements. Moreover, it was the potential medicinal benefits of fisetin powder that encouraged research into the topic.

Although it has been studied and the fisetic benefits and fisetin side effects have been realized, there is still a lot that scientists haven’t been able to

understand about the flavonoid.

The Mechanism Of Action of Fisetin: How does Fisetin work?

Fisetin powder works through multiple pathways in the human body. Fisetin especially works on the antioxidants levels in the body and this is one of its

major benefits. It fights against free radicals, which are unstable ions that will participate in harmful chemical reactions to harm the body. Fisetin’s

antioxidant properties allow it to neutralize these free radicals and hence, reduce the oxidative stress that the body is under.

Another mechanism of action of fisetin is that it blocks the NF-KB pathway. This pathway is important for the production and release of

pro-inflammatory cytokines and eventually, inflammation. NF-KB is a pro-inflammatory pathway that induces gene transcription to synthesize the

inflammatory proteins. When overtly activated, the NF-KB pathway plays an important role in cancer development, allergies, and autoimmune diseases.

Fisetin powder blocks this pathway, hence, acting as an anti-inflammatory supplement.

Fisetin powder also blocks the action of the mTOR pathway. This pathway, much like the NF-KB pathway, is involved in the development of cancer,

diabetes mellitus, obesity, and neurodegenerative diseases. mTOR pathway causes the cells to panic as they struggle to meet the energy demands of

the pathway, resulting in an excessive workload on the cells. What this means is that cells are overworking and producing metabolic waste but there

isn’t sufficient time to clean up the waste resulting in the accumulation of waste. This can be detrimental to cellular health and the blockage of this

pathway by fisetin supplement is how fisetin helps manage obesity, diabetes, and cancer.

Apart from these major mechanisms of action, fisetin is also able to inhibit the activity of lipid-degrading enzymes, lipoxygenases. It also inhibits matrix

metalloproteinases or the MMP family of enzymes. These enzymes are crucial for cancerous cells to be able to invade other tissues, however, with the

use of fisetin powder, that is no longer possible.

What food contains Fisetin?

Fisetin is a plant-based flavone that is primarily extracted from apples and strawberries. It is a pigment of yellow and ochre color in plants, meaning that

most fruits and vegetables of that color are rich in fisetin. Fisetin, in plants, is synthesized from the amino acid phenylalanine, and the accumulation of

this flavone in plants is highly dependent on the environment of the plant. If the plant is exposed to shorter wavelengths of UV rays, then there is an

increase in the production of fisetin. Fisetin powder is made from the isolation of fisetin from the following plant sources.

Plant sources Amount of Fisetin (μg /g)

Toxicodendron vernicifluum: 15000

Strawberry: 160

Apple: 26

Persimmon: 10.6

Onion: 4.8

Lotus root: 5.8

Grapes: 3.9

Kiwifruit: 2.0

Peach: 0.6

Cucumber: 0.1

Tomato: 0.1

What are the benefits of Fisetin?

Fisetin benefits are quite a few, and they have all been seen on animal models. No research has been able to conclusively determine these benefits in

humans as most studies are still in the clinical phase. The different benefits of fisetin include:

Anti-Aging

Aging of the body is marked by a net increase in senescent cells, that are no longer able to divide. These cells release inflammatory signals, which

results in the complications of aging most commonly seen. Most age-related disorders are due to abhorrent inflammation in the body promoted by the

senescent cells. Fisetin powder consumption targets these cells and removes them from the body, hence, reducing inflammation and slowing down the

aging process.

Diabetes management

In animal models, fisetin supplement has been shown to reduce blood sugar levels significantly. This effect of fisetin comes from the flavonoid’s ability

to increase insulin levels, increase glycogen synthesis, and decrease the liver’s ability to initiate gluconeogenesis. Basically, fisetin acts on every pathway

in the body that results in glucose production and stops those while activating the pathways that either store or use up the glucose in the bloodstream.

Anti-Cancer

The anti-cancer effects of fisetin powder differ based on the type of cancer. In a study performed on prostate cancer, fisetin was able to reduce the

growth of cancer by blocking testosterone and DHT receptors, which are important for the growth of prostate cancer. In another study where the

cancer being studied was lung cancer, fisetin supplements were able to increase antioxidants in the blood that had been reduced by tobacco use.

Fisetin was also able to reduce the growth of lung cancer by 67 percent on its own, and 92 percent when combined with a chemotherapy drug. When

used in colon cancer, fisetin significantly reduced the inflammation associated with colon cancer. The study, however, did not mention any effect of

fisetin on cancer growth.

Neuroprotective

When older rats with age-related decline in cognition were given fisetin supplement, there was a significant improvement in their cognitive skills and

memory. In another study, animal models were exposed to neurotoxic substances and then given a fisetin supplement. The test subjects were found to

have not experienced any memory loss due to the supplement. However, it is not known if fisetin can cross the human blood-brain barrier with the

same efficiency as the mice blood-brain barrier.

Fisetin is also neuroprotective in the sense that it prevents the development of neurodegenerative disorders such as Alzheimer’s by reducing the

accumulation of harmful proteins in the brain. Similarly, mice with ALS showed an improvement in their balance and muscle coordination after being

given fisetin powder. They also experienced a prolonged life span than what was expected.

Cardioprotective

Researchers studied the effect of fisetin powder on the cholesterol levels of rats who were fed a high-fat diet. Total cholesterol and LDL levels were

found to have decreased significantly whereas HDL levels almost doubled. The hypothesized mechanism through which fisetin rids the body of

cholesterol is believed to be increased release of it into bile. The reduced cholesterol, overall, has a cardioprotective effect.

All these fisetin benefits point toward anti-aging and longevity of life which should be enough to promote more clinical studies so that the compound

can be approved for medicinal use.

Fisetin Vs Quercetin: is fisetin the same as quercetin?

Quercetin and Fisetin are both plant flavonoids or pigments that are well known for their anti-inflammatory and anti-oxidant properties. They both also

have significant anti-aging properties, which they perform by clearing senescent cells from the body. Fisetin powder, however, has been shown to clear

out the cells with increased efficacy and potency than quercetin.

Fisetin Vs Resveratrol: is fisetin better than resveratrol?

Resveratrol is a polyphenol that is also quite popular for its anti-oxidant properties. Taking quercetin and resveratrol results in a synergistic effect on the

body, although quercetin is more potent at mediating inflammation and managing insulin resistance. Since Fisetin is better at performing these

functions than quercetin, it can be concluded that fisetin supplement is better than resveratrol supplements.

Fisetin and weight loss

Researchers studied the effect of fisetin powder on fat accumulation in the body and it was found that it blocks certain pathways to reduce diet-related

obesity. It targets the mTORC1 signaling pathway. This pathway is important for cell growth and lipid synthesis, hence, inducing fat accumulation in the

body.

How much fisetin should I take: The fisetin dosage?

Fisetin dosage ranges between 2 mg to 5 mg, per kilogram of weight, however, this is not the recommended guideline for the dosage. There is no

specific dosage recommendation for fisetin usage, and speaking to a medical professional would help in determining a fisetin dosage range, specific to

one’s own conditions. In one of the studies conducted with the purpose of assessing the effect of fisetin powder on inflammation caused by colon

cancer, 100 mg per day was required to notice a significant reduction in inflammation.

What are the side effects of fisetin?

Fisetin only recently became the subject of multiple studies and different pieces of research. This late interest in the flavonoid means that most studies

performed have been on animal models or in a lab setting. Not many human studies have been performed to conclusively determine the potential side

effects and toxicities of the supplement. Animal models on exposure to high doses of fisetin supplement did not show any adverse effects, pointing

towards the safety of the supplement.

However, it is important to remember that lack of side effects in animal models does not mean that the risk of side effects in humans does not exist. To

reach that conclusion, more clinical studies need to be performed. In one study that was performed on cancer patients to assess the efficacy of fisetin

powder in managing the symptoms of cancer, both placebo and control groups reported gastric discomfort. Since the side effect was present in both

groups, and both groups were undergoing chemotherapy at the same time, it is hard to conclude that fisetin powder consumption can cause gastric

discomfort.

Fisetin powder may not have any reported side effects but it does interact with certain drugs, resulting in altered metabolism of those drugs. Fisetin

was found to reduce the blood sugar levels in animal models, which is quite a benefit on its own. But when taken in conjunction with anti-diabetic

medications, the glucose-reducing effect of both, the supplement and the drug could be exaggerated. This could result in several health complications.

Fisetin powder is metabolized by the liver, in the same way, that blood thinners are metabolized. Due to this, it is hypothesized that these two would

interact with each other and Fisetin powder would increase the effects of blood-thinning agents.

Fisetin powder and fisetin supplements online

Fisetin powder can be bought online from different fisetin powder manufacturers, in quantities based on the specific need. Buying fisetin bulk amounts

can help with the pricing as well. Fisetin’s price is not that out of range, and it is in the same range as other flavonoid supplements.

When looking to buy a fisetin supplement, it is important to thoroughly look through fisetin powder manufacturers and their manufacturing process.

This is to ensure that proper safety guidelines and manufacturing protocols are followed during the production of the fisetin supplement. It is crucial to

buy pure fisetin powder as it makes for the best fisetin supplement. If the supplier does not follow safety protocols in the extractions and synthesis of

fisetin, the end-product can be contaminated or tainted with ingredients that are either harmful to human health or have no effect on human health,

whatsoever. Either way, the fisetin benefits would not be experienced despite taking the supplement for a long time.

It is always important to look into the ingredients of the fisetin powder being purchased and the concentration ratio of these ingredients to ensure that

pure fisetin powder is being purchased. If this distinction is not made, then there is a huge likelihood of increased fisetin side effects and/or reduced

fisetin benefits, overall.

References

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5527824/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6261287/

https://pubmed.ncbi.nlm.nih.gov/29275961/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4780350/

https://link.springer.com/article/10.1007/s10792-014-0029-3

https://pubmed.ncbi.nlm.nih.gov/29541713/

https://pubmed.ncbi.nlm.nih.gov/18922931/

https://pubmed.ncbi.nlm.nih.gov/17050681/

https://pubmed.ncbi.nlm.nih.gov/29559385/

[cardiococktail]

All About The Health Benefits Of Fisetin

Most people are worried about their health. They would do anything to improve their quality of life. Unfortunately, some people attempt to achieve this goal using the wrong methods. Instead, you should look for natural, alternative methods for dealing with your problems. This is why so many people are switching to plant remedies. Fisetin power is found in a variety of plants and Eudicotyledons. It can also be found in various trees and shrubs including the honey locust and parrot tree.

Furthermore, many fruits and vegetables contain this powder. It can be extracted from fruits and other herbal sources. So, what are the benefits of using this health powder?

What Is It?

Before learning about GM1, it is pertinent to gain a better understanding of Fisetin. What is it? How does it help? Most people know about CMS-121. Well, you should know that Fisetin plays a big role in the overall picture. Isolated fiestin originates in 1833 from the smoke bush. The basic chemical attributes of this chemical were described by Schmidt in 1886. During the 1890s, Kostanecki was the first to define the chemical structure of this chemical.  

Fisetin is both a flavonoid and polyphenol that derives from vegetables, plants, and fruits. The substance is extracted from the natural pigment of cucumbers, onions, Eurasian smoke trees, apples, strawberries, and persimmons.

Experts compare Fiestin to Quercetin, a dietary supplement, with one main difference. This difference is the former is believed to be a senolytic, unlike Quercetin. In addition to this, as a senolytic, Fiestin could possibly be the most robust.

During this time, he studied plant pigments and created new sub-categories including flavonol, chromones, chalcones, and flavones. Fisetin is similar to many other plant polyphenols. It has antioxidant properties and can help protect against stress. In addition to this, the substance offers chemopreventive, chemotherapeutic, and anti-inflammatory properties. It offers a wealth of benefits and this is why so many people are intrigued by it.

Application

People are beginning to use CAD-031 powder and other natural remedies to combat their problems. Fisetin powder is now used for an abundance of purposes including treating rheumatism, hernias, toothaches, skin ulcers, and traumatic injuries. In addition to this, this powder can be used to deal with inflammation.

It can be used as an anti-proliferative to help control the release of the substance. The only downside is that there are some potential side effects including diarrhea, stomach pain, and rheumatoid arthritis. This naturally occurring flavonol can be used in the synthesis of anti-convulsant and anti-inflammatory agents.

Anti-Cancer Properties

Fisetin powder contains anti-cancer properties. These properties help stave of various types of cancer. This could prove to be helpful for health-conscious humans with a family history of cancer. By building your immune system, Fisetin can lower your risk of developing several types of cancer.

Memory Booster

Who couldn’t use a memory booster? With fisetin-based products, it is possible to improve your memory significantly. It is also believed, the substance can stave off brain diseases like dementia and Alzheimer’s, as well as memory loss associated with age.

  An Antioxidant

In addition to being a polyphenol, flavonoid, and senolytic, Fisetin is also believed to be an antioxidant. An antioxidant is a substance with oxidation exhibition capability. This capability works by damaging or destroying, oxidizing agents responsible for causing various diseases, including inflammation and cancer.

Antioxidants neutralize dangerous reactive chemicals known as free radicals. These chemicals have been linked to atherosclerosis, Parkinson’s, Alzheimer’s, arthritis, and lupus. Damage caused by free radicals generally begins as a small tumor, will continues to develop when left undetected.

Research Studies

Over the past 10 to 15 years, several studies have been conducted regarding Fisetin and its benefits on brain cells. It is discovered that this small molecule can easily cross the blood and brain barrier. Once it reaches the brain, it will help with the removal of all senescent cells. This ensures that the substance can help improve overall brain function while improving mental alertness to the top level. J-147 is considered one of the best smart drugs due to its neurogenic and neuroprotective properties.

In June of 2019, a study was conducted on mice that were injected with a neuro-toxin substance. It negatively impacted their muscle control, balance, and behavior so they were no longer able to complete the maze tests. By giving the mice Fisetin, it was possible to remedy this problem. And the wisepowder is the manufacturer of all these products and creates 100% safe and secure. 

  The post All About The Health Benefits Of Fisetin appeared first on Meds News – Health & Medicine Information.

This content was originally published here.

source https://atlantaloser.com/all-about-the-health-benefits-of-fisetin/

[saltyrap]

Few Ways to Enhance Intelligence

Almost everyone has heard about the term IQ (Intelligence Quotient). It is the measure used to determine whether the person is intelligent or not. If the person is intelligent, then determining his intelligence score through some tests is called IQ test. It is a standardized process constructed to evaluate the intelligence of a person through some performances like logical, analytical and creative way. The word intelligence quotient is derived from the German terminology. The person who named this parameter is William Stern in the year of 1912. At that time, he discovered a way to know the intelligence of a student through this standardized process.

The IQ tests incorporates two main theories in it. They are,

1. Unitary theory

2. Multiple theory

The Unitary theory is related to certain factors like person’s ability in solving mathematical and analytical problems. Multiple theory is related to other views of person’s mind like, musical interest, spatial and personnel skills (both intra and inter).

We can improve our intelligence through many ways. The main thing is to find the interests and skills of a person in which they are good at. Some people may be interested in arts and music, some may be in sports and other may be in studies. In some cases, people won’t be knowing about their abilities and interests. Recall your old experiences, you are not finding it clear about your interests then think about present. If you are fond of activities like dance, singing, art or sports. The world is yours. Make use of the opportunities in the respective field and act accordingly.

Diet also plays a very important role in the enhancement of intelligence. Avoid the food with high-fat content and include green vegetables, fishes and grains in your food which are the rich sources of vitamins helps to improve your memory power. Many medicinal alternatives are available in the market like Fisetin Nootropics powder, which acts as a memory enhancers or intelligence enhancers with no side effects.

Not all the people are born genius. We can find only few people who are genius. They don’t have to put so much of efforts to get the things done. They even don’t need to improve their intelligence as they are born intelligent and they are already a better performer. It doesn’t mean that only the people who are genius can succeed in life. It’s better to know the thing in which you are excellent and try to incorporate the things related to the same. Intelligence and brain power are directly proportional to each other. As intelligence improves, brain power improves and subsequently maximizes the capability of achieving more.

[candygetsfit]

How to Enhance Brain Health With Nootropics

Are you looking for the best Nootropics? Nootropics are natural herbs that can enhance the brain, provide overall health and help restore the body's neurotransmitters to their optimum levels. Some of the most popular ingredients include Gingko Biloba, L-Arginine, Ginseng, and Shatavri. Each of these ingredients has unique properties and is used in a specific product to enhance memory, mood, focus, and more.

Fisetin helps to increase brain function by increasing blood flow to the brain. It also helps to improve overall brain function by increasing the flow of oxygen to the cells and synapses in the brain. Gingko biloba can be taken in a variety of ways including drinking tea or taking a supplement as well as eating food that contain it. L-Arginine and Shatavri are also used in a variety of ways to improve cognitive enhancers and to improve the overall health and brain function.

 No caffeine is a very common ingredient in the Best Nootropics. Studies have shown that caffeine can help to enhance overall brain function as well as improve short term memory and focus. While there is some evidence that caffeine does promote short term memory, there is no real proof that it can improve long term memory or focus. In fact, some studies that looked at the effect of caffeine on children showed that it had a negative impact on their ability to focus. That said, many people prefer coffee or soft drinks to tea or other forms of caffeine because they believe that those drinks contain fewer calories and don't have the negative impact that caffeine has on the body. If you are concerned about losing too much weight, coffee or soft drinks are a good choice because they have significantly lower calories and a relatively small amount of calories per serving.

 The makers of the Best Nootropics didn't set out to create a mental booster. They created the product to improve focus, memory, and concentration. The noocube supplement contains ginseng, an ancient Chinese herb that has been shown to improve mood, energy levels, and mental function. There is also ginkgo biloba, another herb that is considered to be the best nootropic supplement around. Ginkgo is known to boost mood, focus, and mental alertness.

 The makers of the Best Nootropics did include other natural ingredients in the noocube supplement. These natural ingredients include ginseng, ginkgo, and mullein. All three of these ingredients have been shown to support a healthy sense of focus and memory. Yet, despite their effectiveness, it is unlikely that the combination of all three will have a significant impact on a person's memory or focus.

 The makers of the Best Nootropics know that many people are looking for a nootropics supplement that will act like smart drugs. They have done the research to ensure that they have included only natural substances that are compatible with human functioning. While the nootropics products claim to boost brain function, they do not actually do so. In order for them to be called "smart drugs," they need to have some sort of an effect on the central nervous system. The makers of the Best Nootropics take this to be proof that their product will not act as a "smart drug." However, these claims are misleading.

 Regardless of whether or not the makers of Best Nootropics believe that there are noocuprous compounds in their products, the products do have the ability to enhance brain function. The best nootropic ginkgo biloba extract and nootruff extract that the company sells can all boost a person's memory and focus, though. It just requires a little bit of time and patience. To find the best nootropics for you, consult a certified brain function specialist, a doctor who specializes in brain function, or at a medical clinic that offers nootropic medication. You can also purchase a variety of nootropic supplements at your local drugstore.

 As you look for the best nootropic ginkgo biloba extract, nootruff extract, and other supplements that will help boost your brain health, remember that natural is always better. Natural substances are less likely to cause negative side effects and they are more likely to improve memory and focus. If you take the time to learn about the various brain enhancing products on the market, then you will be able to choose one that suits your personal needs and desires. Best Nootropics is a popular brand that contains a variety of different nootropic ingredients.

[caregenic]

Best Nootropics Supplements For ADHD

Best Nootropics are the best supplements for athletes and people who are in need of mental clarity. If you are thinking of taking any type of supplement, you should know that not all nootropics are created equally. There are a few neurotransmitters, like serotonin, that affect our mood, energy level, and cognitive function. Fisetin powder enhance overall brain functioning, while others act as cognitive enhancers or busters.

One of the best nootropics is dynamine. dynamine (also known as ephedrine) is a natural stimulant that help improve focus, improve memory function, and increase energy. It also increases mental clarity and increases energy. Ephedrine mimics caffeine and can be found in coffee, tea, chocolate, and energy drinks.

 Another one of the best nootropics is acetyl-L-carnitine. Acetyl-L-carnitine has been shown to reduce fatigue and elevate energy levels. One of its side effects is a lowered heart rate. This supplement can be found in energy drinks, liposomes, and health drinks.

 The third best depot is noopeptamine. This ingredient is believed to increase brain sensitivity. Noopeptamine acts in the central nervous system and is a partial agonist for dopamine receptors. Studies have found it to be effective in blocking seizures and in increasing mental clarity. Noopeptamine is available in a liquid, powder, and pill form.

 Brain O Brain capsule is one of the most popular and powerful nootropic herbs on the market today. Brain O Brain boosts cognitive function and increases focus and memory. It provides the body with the most powerful source of acetylcholine synthesis. It works synergistically with ginkgo biloba to improve overall cognitive and physical performance.

 The last of our four best nootropics is L-tyrosine. L-tyrosine is a natural neurotransmitter that enhances dopamine release. It helps improve memory and attention. It also improves the neurotransmitters activity and releases growth hormone when taken as a supplement.

 What makes L-tyrosine stand out from other nootropic herbs is that it also boosts acetylcholine receptors function. It does this by triggering neurogenesis. Neurogenesis is the process in which the brain creates new neurons. Studies have shown that neurogenic effect promotes the formation of new brain cells and helps enhance cognition.

In addition to these three ingredients, there are many other ingredients that help to improve your focus and memory. For example, ginkgo biloba, ginseng, l-glutamine, and caffeine have been shown to increase brain plasticity. This means that using a nootropic stack can increase not only your memory and focus, but also the health of your brain.

 To find the best nootropic stack you should take into consideration the studies made on each ingredient. If a study was done on L-glutamine, it proved that it can increase your recall capacity. But it was also found that it can increase your thinking speed. Studies on ginkgo biloba showed that it can increase your cognitive function. And the best anti-oxidants are those that can prevent free radical oxidation.

 Let's look at a particular neurotransmitter and one of the best nootropic stacks for adhd: phosphatidylserine. Serotonin is a neurotransmitter. When the levels of serotonin in the brain to decrease, the ability of the individual to focus and stay focused decreases as well. Glutamate, another neurotransmitter, has been shown to be the precursor of serotonin. As we age, our ability to produce serotonin declines and thus our reasoning and attention level becomes sluggish. As an interesting side note, another substance often used in ADHD treatment is naltrexone which decreases the levels of norepinephrine in the brain.

 Now to find the most effective anti-depressant for ADHD, you need to look for aniracetam is one of the best nootropics for depression. Aniracetam has been found to reduce stress by increasing the amount of oxygen in the brain, which improves mood. It also increases the release of dopamine and noradrenaline. Together, these three neurotransmitters work together to improve mood, alleviate pain and treat disorders like anxiety and insomnia.

 Another brain tonic to consider is the herb known as rhodiola rosea. Research has shown that this herb can actually reverse the harmful process that is called neuroplasticity. Neuroplasticity is basically when a nerve is stimulated and it causes the cells in the brain to increase in size. This then causes the neurons in the area to fire at a faster rate than normal, which causes the person to experience a certain effect in a short amount of time. Rhodiola rosea has been found to prevent this type of neuroplasticity, which allows the brain to function at its optimum level.

 The best nootropic supplements are natural brain boosters that will help you maintain your brain to function at an all time high. These nootropics are the best option to use because they have no known negative side effects. Plus, they are very inexpensive. Try some nootropic supplements like nootropics capsules today and start benefiting from a healthy brain!

[tips-from-john]

FLOW FORCE MAX - FLOWFORCE MAX - FLOW FORCE MAX REVIEWS - FLOWFORCE MAX REVIEWS

FlowForce Max Review: Comprehensive Assessment of Prostate Health Support

Introduction

The importance of prostate health in men's overall wellbeing is often overlooked until complications arise. FlowForce Max, with its unique natural formula, has garnered attention. This review delivers a detailed examination of FlowForce Max, focusing on its benefits, ingredients, and effectiveness.

Evaluating FlowForce Max

FlowForce Max is a botanical supplement designed to boost prostate health, featuring a blend of herbs and minerals. This review delves into how FlowForce Max offers a fresh approach for men seeking natural methods to enhance their prostate health, vitality, libido, and overall wellness.

Product Details

Name: FlowForce Max Category: Prostate Health Supplements Form: Capsules Amount: 30 capsules per package Recommended Dosage: One capsule daily

Pricing

One-month supply: $69 per package Three-month supply: $177 (equivalent to $59 per package) Six-month supply: $294 (equivalent to $49 per package) FlowForce Max is available solely via its official online platform, ensuring authenticity and high quality.

Ingredients and Their Efficacy

FlowForce Max is formulated with various natural components, each backed by scientific research. Key ingredients like Graminex Flower Pollen Extract, Fisetin, Luteolin, and others are known for their anti-inflammatory and antioxidative properties. This section thoroughly analyzes the contribution of each ingredient in enhancing prostate health.

Functioning of FlowForce Max

FlowForce Max addresses prostate inflammation and bolsters immune defenses. Its antioxidants play a vital role in purifying the prostate, thereby improving its function. This review segment closely examines the mechanism, highlighting the supplement's effectiveness in prostate health support.

Benefits of FlowForce Max

Prostate Detoxification FlowForce Max's potent antioxidants assist in removing environmental toxins, easing the burden on the prostate. This detox process contributes to a healthier state of the gland, enhancing its functionality. Reduction of Frequent Urination FlowForce Max efficiently reduces inflammation, alleviating stress on the urinary tract. This results in fewer nighttime trips to the bathroom, enhancing sleep quality and overall life satisfaction.

Target Audience for FlowForce Max

FlowForce Max is generally safe but not recommended for men under 18 or those heavily medicated for chronic conditions. This section specifies the suitable demographic for the supplement and safety guidelines.

Consumer Feedback and Personal Assessment

This part presents authentic user reviews and my own evaluation of FlowForce Max. It includes customer experiences and personal observations, providing a comprehensive view of the product's effectiveness.

Conclusion

FlowForce Max emerges as a robust natural option for maintaining prostate health, combining scientifically proven ingredients in a carefully crafted formula. Its influence goes beyond prostate health, positively affecting energy levels, libido, and general vitality.

KEY MOMENTS OF THIS FLOW FORCE MAX REVIEW

00:01 FlowForce MaxReview Intro

00:25 What is FlowForce Max?

00:57 FlowForce Max Official Website

01:48 FlowForce Max Ingredients

02:25 Does FlowForce Max Powder Really Work?

02:52 FlowForce Max Side Effects

03:19 FlowForce Max FDA Approved

03:28 How To Take FlowForce Max Supplement?

03:56 FlowForce Max Guarantee

04:15 FlowForce Max Reviews Conclusion

Extra tags:

flow force max, flow force max reviews, max force flow for prostate, flow force max for healthy prostate, flow force max review, flow force max drops, flowforce max, flow force max results, flow force max how to use, does flow force max work, flow force max supplement, flow force max ingredients, flow force max user reviews, flowforce max works works, flowforce max ingredients, flowforce max composition, flow, flow force max customer reviews, flowforce max reviews

#flowforcemaxreviews #flowforcemax #flowforcemaxreview

The post FlowForce Max Reviews was first published on Legenda Pop BR Channel.

[downsvale]

15 things that slow down Alzheimer’s Disease

Despite the fact that there's no cure, there are things you can never really prevent, delay, or slow down Alzheimer's sickness and dementia.

Our regular way of life decisions is the most significant element with regard to Alzheimer's prevention.

It's predicted that when the first wave of baby boomers arrive at the age of 85 out of 2031, in excess of 3 million individuals beyond 85 years old will have Alzheimer's. In addition to the emotional devastation of memory loss, the infection can cause financial ruin.

Despite the fact that the numbers are shocking, they are not miserable. As analysts press forward searching for a cure, they urge individuals in danger to make a positive way of life changes to keep the sickness from increasing a dependable balance. Starting at now, prevention is the solution for Alzheimer's.

Here are 15 things you can improve your cerebrum well being and work to prevent Alzheimer's in the new year:

1. Learning new things

Challenging your mind is acceptable—yet testing it in totally new ways is far and away superior with regards to preventing or slowing back the movement of Alzheimer's sickness. Learning new things—another language, an instrument, a sport, a complicated game like chess—helps increment the number of cerebrum neurotransmitters (the pieces of the nerve cell that transmit driving forces to different cells). These cells can diminish with age and Alzheimer's infection.

2. Drink raw fruit and vegetable juices and Add Vitamin K supplement to your diet.

Drinking fruit and vegetable juices multiple times each week could cut the danger of building up Alzheimer's by 76%. Add a vitamin K supplement to your eating routine Known as "the forgotten vitamin," vitamin K assumes a significant role in anti-aging may prevent Alzheimer's. Since vitamin K isn't found in many multivitamins numerous individuals consume it through green leafy vegetables or a vitamin K supplement.

3. Reduce stress.

Numerous investigations have connected uneasiness with the advancement of Alzheimer's, particularly in individuals who are as of now in danger for the sickness. An ongoing report demonstrated that individuals who had mild cognitive impairment and revealed high levels of tension were 135% bound to create Alzheimer's.

4. Commit to regular exercise.

Regular exercise may safeguard hippocampal volume which is the initial segment of the cerebrum assaulted by Alzheimer's. Great exercise decisions including walking briskly, dancing, swimming, cycling, and in any event, gardening. Getting your blood streaming with ordinary physical movement helps your mind just as your muscles.

Exercise likewise supports blood and oxygen stream to the cerebrum and helps cut the danger of weight, diabetes, and hypertension—all factors that raise the danger of Alzheimer's. There's additional: Exercise can likewise start the development of new brain cells and slow down the cerebrum shrinkage that happens with age. Focus on in any event 30 minutes of vigorous aerobic exercise in any event three times each week.

5. Laugh more.

Scientists have discovered that laughter is more than useful for the soul. Playing, laughing, and being active assists to engage the brain, develop new brain cells, and at last prevent Alzheimer's.

6. Run 15 miles per week.

Logging in any event 15 miles for each week may reduce your danger of Alzheimer's by 40% as indicated by another investigation.

7. Consume more fruits.

Fruits containing a compound called fisetin has Alzheimer's battling properties. Regularly found in strawberries and mangos, fisetin has anti-inflammatory properties that successfully battled the beginning of Alzheimer's in mice.

8. Make time for meditation.

Calming your mind might be a higher priority than you may think in Alzheimer's prevention. Individuals who performed meditation and yoga had less mind atrophy than the individuals who didn't. Meditation can increment protective tissue in the cerebrum, can assist seniors with feeling less focused, and decreases the hormone cortisol, which has been known to expand the danger of creating dementia.

9. Eat more Fish.

Fish is high in omega-3 fatty acids which can control blood clotting, form cell films in the cerebrum, ensure against heart illness, secure against mind atrophy, and slow Alzheimer's and dementia.

10. Quit smoking.

A report from the World Health Organization found that smokers have a 45% higher danger of creating dementia than non-smokers and furthermore asserted that 14% of all dementia cases might be attributed to smoking.

11. Adopt a Mediterranean diet.

Following a Mediterranean eating routine high in fish, chicken, olive oil, and different nourishments high in omega-3s may improve cognition and lower the danger of cognitive decline.

12. Sleep better.

Lack of sleep has been connected to a myriad of medical issues including pressure and expanded cortisol, the two of which are chance variables for Alzheimer's. Moreover, a waste-depleting framework that frees the mind from beta-amyloid is increasingly dynamic while we rest. Attempt to get in any event eight hours of good rest each night, and on the off chance that you can't, supplement your rest time with snoozes.

13. Limit sugar intake.

Diabetes has been firmly connected to Alzheimer's with certain analysts, in any event, considering the ailment of the third kind of diabetes. Manage sugar intake and glucose levels to keep your mind healthy.

14. Brushing and flossing

Researchers currently perceive oral hygiene as a significant factor for optimizing mind well being. "A portion of the bacteria in the mind originates from the gums. Those bacteria can go to the heart or the mind and cause irritation … which kills brain cells and is a significant trigger for Alzheimer's. Everybody be strict about flossing your teeth. Don't simply brush them; floss them, as well!  

15. Learn early Alzheimer’s symptoms.

Early detection is the way to easing back the movement of Alzheimer's. Learning and perceiving side effects as they initially show up implies that greater treatment choices are accessible. Early signs and symptoms of Alzheimer's can incorporate forgetting about dates, vision issues and trouble completing familiar tasks.

Do you have a goal to diminish your danger of dementia this year? What will you do to prevent Alzheimer's?

Nothing to stress over there is a one stop answer for dementia patients is Downsvale Nursing Home Center situated in Dorking, Surrey, UK. Nursing Home contribution complete individual focused care in a pure setting settled in the delightful moving scenes of Boxhill in Surrey. It is near all comforts and offers 24 hour care for you and your friends and family in a mindful and safe spot for all who stay here.

Visit: https://www.downsvale.co.uk/ Or Call 01306772220

[lauramalchowblog]

How Fasting, Calorie Restriction, and a Fasting-Mimicking Diet Can Encourage Longevity

Hi folks, today’s post comes from my friend Max Lugavere, New York Times best-selling author of Genius Foods and The Genius Life, which will be available for purchase on March 17, 2020. Max is a young guy, but he’s accomplished a lot so far, including an impressive bit of research and writing about longevity and how to age optimally with grace. I know you’ll enjoy Max diving into the weeds a bit about the nutrient sensors, proteins, and catalysts that may help us live long, healthy, thriving lives. This post comes from an excerpt from Max’s newest book The Genius Life.

From now until March 11, 2020 at 11:59 p.m. PST, enter for your chance to win a FREE copy of The Genius Life as well as Primal Kitchen salad dressings and Primal Sun. All you have to do is head over to Instagram, follow @marksdailyapple and @maxlugavere, and tag some friends in the comments of the giveaway post. Three winners will be selected and notified via DM. Good luck, and enjoy the excerpt.

When it comes to slowing down the clock, life extension is indeed possible. The catch? There are two: it involves calorie restriction, and it has only been successfully demonstrated in lab animals. Studying longevity in humans is a bit more challenging. We don’t sleep in labs, we live a lot longer, and we like to eat. (Correction: we love to eat.) So while most of us would happily opt for a 40 percent increase on our life spans like food-deprived lab rats seem to achieve, we need a better route to get there.1

Thankfully, longevity researchers have begun to look for calorie restriction mimetics—compounds or strategies that can mimic the beneficial effects of prolonged calorie restriction but without the misery that goes along with it. Some emerging food-based candidates include resveratrol, the antioxidant found in red wine; fisetin, found in strawberries and cucumbers; and curcumin, found in turmeric. The most promising of all, however, may derive from a practice as old as humanity itself: fasting.

How do the cells of the body know when we’ve decided to fast? Answering that question has been mission critical for longevity researchers. Why? Because if we’re able to find the signal that tells our cells “food is scarce,” we may be able to activate those signals on demand and reap the myriad cellular benefits that ensue. Plus, we’d be able to do it without committing to a lifetime of starving ourselves. The chief nutrient sensor that our bodies use to assess whether or not we are in a calorie-deprived state is—and it’s a mouthful—adenosine monophosphate-activated protein kinase or, simply, AMPK.

AMPK senses overall energy (i.e., calorie) availability. You may have heard of adenosine triphosphate, or ATP, the basic energy currency of cells. Under normal circumstances, ATP is able to be generated to meet the demands of our activity. But when ATP can’t get replenished fast enough, such as during calorie restriction or high-intensity exercise, AMP builds up in the cell. AMP is an energy-depleted version of ATP, and too much AMP leads to the activation of AMPK.

AMPK sits at the helm of coordinating the body’s response to the sudden lack of energy. It promotes increased fat burning, better glucose handling, improved insulin sensitivity, and reduced inflammation. It also decreases the liver’s synthesis of fats like cholesterol and triglycerides.2 And, since AMPK’s duties include making sure your cells are better prepared for next time, it spurs the creation of healthy, new energy-generating mitochondria (dysfunction of these little power plants is associated with aging and numerous age-related diseases). This is all why activating AMPK is considered a powerful lever for the life-extending properties of calorie restriction.

Other Potential AMPK Activators:

Astaxanthin (in krill oil and wild salmon)

Berberine

Coffee

Cold exposure

Curcumin (in turmeric)

Extra-virgin olive oil

Green tea

Heat (e.g., saunas)

Metformin (a type 2 diabetes drug)

Quercetin (in capers and onions)

Reishi mushroom

Resveratrol

Sulforaphane (in cruciferous veggies)

Vinegar

What might you do to support the activation of AMPK? Calorie restriction, of course. Other than that, high-intensity interval training, which I describe in more detail on page 122 in my book The Genius Life, is a potent AMPK activator, precisely because it creates a temporary state of energy deprivation. And new research suggests that a few hours of daily fasting can also activate this pathway. By simply eating less frequently, we allow AMPK to become active, whereas eating around the clock keeps AMPK perpetually subdued. Avoid food for the first hour or two (or three) after waking up and avoid food for two to three hours before bed.

Slowing the Clock

One pathway that AMPK stimulates is the FOXO family of proteins. One of them, FOXO3, has been proposed as a longevity protein. It boosts stress resilience (important if you want to live a long time) and may help prevent age-related diseases including cardiovascular disease, type 2 diabetes, cancer, and neurodegenerative diseases. Some lucky people have genes that make their FOXO3 more active, and those people have markedly higher odds of living to one hundred.

Genes or not, you can activate FOXO3 just as easily.

For FOXO3 to activate, it needs a signal, and AMPK is just that. While eating around the clock keeps AMPK chronically deactivated, constraining your feeding window to eight to twelve hours every day encourages AMPK—and subsequently FOXO3—to ramp up. (FOXO3 is also sensitive to insulin, which acts like a nutrient sensor for glucose availability and is discussed on pages 12–13. By keeping insulin within a normal healthy range with a lower carbohydrate diet among other things, we allow FOXO3 to come out of its hole.)

Finally, there’s mTOR, which may be the most potent antiaging protein of all. mTOR was discovered decades ago while scientists were investigating how a strange bacterial compound discovered on Easter Island seemed to exhibit powerful anticancer effects. It appeared to work by inhibiting a protein in the body involved in cell proliferation, which is increased in cancer. The compound was named rapamycin for Rapa Nui, the Polynesian name for the island on which it was discovered, and its target, the anticancer protein, came to be known as mTOR, or mammalian target of rapamycin.3

mTOR promotes storage and growth. As with insulin, this can be highly beneficial when that growth occurs in your muscle tissue, which mTOR helps to achieve. It is also an important player in the formation of synapses—the connections between brain cells—and neuroplasticity, which is your brain’s ability to change over time. These processes all require mTOR-regulated growth.

But mTOR also has a dark side. Too much mTOR activity has been linked with autism, seizures, and certain cancers.4 It can even accelerate aging. When activated, it’s the central gatekeeper to the house-cleaning process known as autophagy. Autophagy clears away old and damaged cell components, such as old mitochondria—the energy generators of your cells—making way for new powerhouses to be created. But by being stuck in an always-on state, this rejuvenation process is blocked. We can see this play out in old mice, whose lives can be extended by up to 60 percent by inhibiting mTOR with rapamycin.5 Rapamycin is not a free lunch, however, and its chronic use is associated with numerous potential side effects such as insulin resistance, the hallmark of type 2 diabetes. This begs the question: is there a healthier way of inhibiting mTOR?

mTOR is sensitive to two things: dietary protein and energy availability. When protein is abundant and energy is flowing, mTOR is revved up. When energy is lacking or protein is restricted, mTOR is inhibited. By limiting our food consumption to eight hours a day—effectively half the feeding time of your average person—we can easily achieve both and spend more time in an mTOR-inhibited state.

And while the story on fasting and longevity is still being written, one proposed method has emerged, with clinical research to back it up.

The Fasting-Mimicking Diet

The raw power of activating AMPK and simultaneously inhibiting mTOR was on display with the results of a fasting protocol devised by scientists at the University of Southern California, led by gerontologist Valter Longo. The research suggests that a periodic very low-calorie diet can not only potentially extend life and health span, but even treat conditions like multiple sclerosis and type 1 diabetes.

It’s known as the fasting mimicking diet. When it was first tested in mice, Dr. Longo and company witnessed essentially a “resetting” of the immune system. The energy-restricted diet destroyed old and dysfunctional autoimmune cells, which were then re-created in a non-autoimmune state during the refeeding process.6 The rejuvenation of the immune system mimicked what Dr. Longo calls “an embryonic-like program,” causing an increase in healthy new stem cells similar to those seen in development.

We don’t often get to restart with a clean slate, but that’s what fasting seemed to do for these rodents’ immune systems. Moving on to higher-level organisms, the human version of the fasting mimicking diet involved five consecutive days of very low-calorie eating. How low? About half of participants’ normal calorie intake. And the calories were specifically intended to come predominantly from veggies and healthy Mediterranean fats like extra-virgin olive oil. It was then repeated monthly, for a total of three months.

By the end, the subjects had decreased risk factors and biomarkers for aging, diabetes, and neurodegenerative and cardiovascular disease, without any major adverse effects and with just a few days of calorie restriction per month. The diet was also deliberately low in protein, but it’s hard to know whether the benefits seen were due to protein restriction, or calorie restriction in general. Independent of calorie restriction, protein restriction hasn’t yet proved beneficial in humans—quite the opposite, actually—and is likely a recipe for weight gain and muscle loss, especially over the long term.

The takeaway here is that aside from minding your meal timing, occasional low-calorie dieting may be useful for a long and healthy life. It makes sense from an evolutionary standpoint that our bodies would know what to do once food became scarce, since it’s unlikely our ancestors had successful hunts all year round.

Pick up a copy of Max’s book, The Genius Life, on or after March 17, 2020, or pre-order your copy today and get a number of generous freebies, including “The 10 Supplements for Better Brain Function.”

References

1. Les Dethlefsen et al., “The Pervasive Effects of an Antibiotic on the Human Gut Microbiota, as Revealed by Deep 16S rRNA Sequencing,” PLOS Biology 6, no. 11 (2008): e280, doi:10.1371/journal.pbio.0060280.

2. Tsepo Ramatla et al., “Evaluation of Antibiotic Residues in Raw Meat Using Different Analytical Methods,” Antibiotics 6.4 (2017): 34, doi:10.3390/antibiotics6040034; Khurram Muaz et al., “Antibiotic Residues in Chicken Meat: Global Prevalence, Threats, and Decontamination Strategies: A Review,” Journal of Food Protection 81, no. 4 (2018):619–27.

3. Marcin Bara?ski et al., “Higher Antioxidant and Lower Cadmium Concentrations and Lower Incidence of Pesticide Residues in Organically Grown Crops: A Systematic Literature Review and Meta-Analyses,” British Journal of Nutrition 112, no. 5 (2014):794–811.

4. Jotham Suez et al., “Post-antibiotic Gut Mucosal Microbiome Reconstitution Is Impaired by Probiotics and Improved by Autologous FMT,” Cell 174, no. 6 (2018): 1406–23.

5. Ruth E. Brown et al., “Secular Differences in the Association Between Caloric Intake, Macronutrient Intake, and Physical Activity with Obesity,” Obesity Research & Clinical Practice 10, no. 3 (2016): 243–55.

6. Tetsuhide Ito and Robert T. Jensen, “Association of Long-Term Proton Pump Inhibitor Therapy with Bone Fractures and Effects on Absorption of Calcium, Vitamin B12, Iron, and Magnesium,” Current Gastroenterology Reports 12, no. 6 (2010): 448–57, doi:10.1007/s11894-010-0141–0.

(function($) { $("#dfUziKl").load("https://www.marksdailyapple.com/wp-admin/admin-ajax.php?action=dfads_ajax_load_ads&groups=674&limit=1&orderby=random&order=ASC&container_id=&container_html=none&container_class=&ad_html=div&ad_class=&callback_function=&return_javascript=0&_block_id=dfUziKl" ); })( jQuery );

window.onload=function(){ga('send', { hitType: 'event', eventCategory: 'Ad Impression', eventAction: '67624' });}

The post How Fasting, Calorie Restriction, and a Fasting-Mimicking Diet Can Encourage Longevity appeared first on Mark's Daily Apple.

How Fasting, Calorie Restriction, and a Fasting-Mimicking Diet Can Encourage Longevity published first on https://venabeahan.tumblr.com

[jesseneufeld]

How Fasting, Calorie Restriction, and a Fasting-Mimicking Diet Can Encourage Longevity

Hi folks, today’s post comes from my friend Max Lugavere, New York Times best-selling author of Genius Foods and The Genius Life, which will be available for purchase on March 17, 2020. Max is a young guy, but he’s accomplished a lot so far, including an impressive bit of research and writing about longevity and how to age optimally with grace. I know you’ll enjoy Max diving into the weeds a bit about the nutrient sensors, proteins, and catalysts that may help us live long, healthy, thriving lives. This post comes from an excerpt from Max’s newest book The Genius Life.

From now until March 11, 2020 at 11:59 p.m. PST, enter for your chance to win a FREE copy of The Genius Life as well as Primal Kitchen salad dressings and Primal Sun. All you have to do is head over to Instagram, follow @marksdailyapple and @maxlugavere, and tag some friends in the comments of the giveaway post. Three winners will be selected and notified via DM. Good luck, and enjoy the excerpt.

When it comes to slowing down the clock, life extension is indeed possible. The catch? There are two: it involves calorie restriction, and it has only been successfully demonstrated in lab animals. Studying longevity in humans is a bit more challenging. We don’t sleep in labs, we live a lot longer, and we like to eat. (Correction: we love to eat.) So while most of us would happily opt for a 40 percent increase on our life spans like food-deprived lab rats seem to achieve, we need a better route to get there.1

Thankfully, longevity researchers have begun to look for calorie restriction mimetics—compounds or strategies that can mimic the beneficial effects of prolonged calorie restriction but without the misery that goes along with it. Some emerging food-based candidates include resveratrol, the antioxidant found in red wine; fisetin, found in strawberries and cucumbers; and curcumin, found in turmeric. The most promising of all, however, may derive from a practice as old as humanity itself: fasting.

How do the cells of the body know when we’ve decided to fast? Answering that question has been mission critical for longevity researchers. Why? Because if we’re able to find the signal that tells our cells “food is scarce,” we may be able to activate those signals on demand and reap the myriad cellular benefits that ensue. Plus, we’d be able to do it without committing to a lifetime of starving ourselves. The chief nutrient sensor that our bodies use to assess whether or not we are in a calorie-deprived state is—and it’s a mouthful—adenosine monophosphate-activated protein kinase or, simply, AMPK.

AMPK senses overall energy (i.e., calorie) availability. You may have heard of adenosine triphosphate, or ATP, the basic energy currency of cells. Under normal circumstances, ATP is able to be generated to meet the demands of our activity. But when ATP can’t get replenished fast enough, such as during calorie restriction or high-intensity exercise, AMP builds up in the cell. AMP is an energy-depleted version of ATP, and too much AMP leads to the activation of AMPK.

AMPK sits at the helm of coordinating the body’s response to the sudden lack of energy. It promotes increased fat burning, better glucose handling, improved insulin sensitivity, and reduced inflammation. It also decreases the liver’s synthesis of fats like cholesterol and triglycerides.2 And, since AMPK’s duties include making sure your cells are better prepared for next time, it spurs the creation of healthy, new energy-generating mitochondria (dysfunction of these little power plants is associated with aging and numerous age-related diseases). This is all why activating AMPK is considered a powerful lever for the life-extending properties of calorie restriction.

Other Potential AMPK Activators:

Astaxanthin (in krill oil and wild salmon)

Berberine

Coffee

Cold exposure

Curcumin (in turmeric)

Extra-virgin olive oil

Green tea

Heat (e.g., saunas)

Metformin (a type 2 diabetes drug)

Quercetin (in capers and onions)

Reishi mushroom

Resveratrol

Sulforaphane (in cruciferous veggies)

Vinegar

What might you do to support the activation of AMPK? Calorie restriction, of course. Other than that, high-intensity interval training, which I describe in more detail on page 122 in my book The Genius Life, is a potent AMPK activator, precisely because it creates a temporary state of energy deprivation. And new research suggests that a few hours of daily fasting can also activate this pathway. By simply eating less frequently, we allow AMPK to become active, whereas eating around the clock keeps AMPK perpetually subdued. Avoid food for the first hour or two (or three) after waking up and avoid food for two to three hours before bed.

Slowing the Clock

One pathway that AMPK stimulates is the FOXO family of proteins. One of them, FOXO3, has been proposed as a longevity protein. It boosts stress resilience (important if you want to live a long time) and may help prevent age-related diseases including cardiovascular disease, type 2 diabetes, cancer, and neurodegenerative diseases. Some lucky people have genes that make their FOXO3 more active, and those people have markedly higher odds of living to one hundred.

Genes or not, you can activate FOXO3 just as easily.

For FOXO3 to activate, it needs a signal, and AMPK is just that. While eating around the clock keeps AMPK chronically deactivated, constraining your feeding window to eight to twelve hours every day encourages AMPK—and subsequently FOXO3—to ramp up. (FOXO3 is also sensitive to insulin, which acts like a nutrient sensor for glucose availability and is discussed on pages 12–13. By keeping insulin within a normal healthy range with a lower carbohydrate diet among other things, we allow FOXO3 to come out of its hole.)

Finally, there’s mTOR, which may be the most potent antiaging protein of all. mTOR was discovered decades ago while scientists were investigating how a strange bacterial compound discovered on Easter Island seemed to exhibit powerful anticancer effects. It appeared to work by inhibiting a protein in the body involved in cell proliferation, which is increased in cancer. The compound was named rapamycin for Rapa Nui, the Polynesian name for the island on which it was discovered, and its target, the anticancer protein, came to be known as mTOR, or mammalian target of rapamycin.3

mTOR promotes storage and growth. As with insulin, this can be highly beneficial when that growth occurs in your muscle tissue, which mTOR helps to achieve. It is also an important player in the formation of synapses—the connections between brain cells—and neuroplasticity, which is your brain’s ability to change over time. These processes all require mTOR-regulated growth.

But mTOR also has a dark side. Too much mTOR activity has been linked with autism, seizures, and certain cancers.4 It can even accelerate aging. When activated, it’s the central gatekeeper to the house-cleaning process known as autophagy. Autophagy clears away old and damaged cell components, such as old mitochondria—the energy generators of your cells—making way for new powerhouses to be created. But by being stuck in an always-on state, this rejuvenation process is blocked. We can see this play out in old mice, whose lives can be extended by up to 60 percent by inhibiting mTOR with rapamycin.5 Rapamycin is not a free lunch, however, and its chronic use is associated with numerous potential side effects such as insulin resistance, the hallmark of type 2 diabetes. This begs the question: is there a healthier way of inhibiting mTOR?

mTOR is sensitive to two things: dietary protein and energy availability. When protein is abundant and energy is flowing, mTOR is revved up. When energy is lacking or protein is restricted, mTOR is inhibited. By limiting our food consumption to eight hours a day—effectively half the feeding time of your average person—we can easily achieve both and spend more time in an mTOR-inhibited state.

And while the story on fasting and longevity is still being written, one proposed method has emerged, with clinical research to back it up.

The Fasting-Mimicking Diet

The raw power of activating AMPK and simultaneously inhibiting mTOR was on display with the results of a fasting protocol devised by scientists at the University of Southern California, led by gerontologist Valter Longo. The research suggests that a periodic very low-calorie diet can not only potentially extend life and health span, but even treat conditions like multiple sclerosis and type 1 diabetes.

It’s known as the fasting mimicking diet. When it was first tested in mice, Dr. Longo and company witnessed essentially a “resetting” of the immune system. The energy-restricted diet destroyed old and dysfunctional autoimmune cells, which were then re-created in a non-autoimmune state during the refeeding process.6 The rejuvenation of the immune system mimicked what Dr. Longo calls “an embryonic-like program,” causing an increase in healthy new stem cells similar to those seen in development.

We don’t often get to restart with a clean slate, but that’s what fasting seemed to do for these rodents’ immune systems. Moving on to higher-level organisms, the human version of the fasting mimicking diet involved five consecutive days of very low-calorie eating. How low? About half of participants’ normal calorie intake. And the calories were specifically intended to come predominantly from veggies and healthy Mediterranean fats like extra-virgin olive oil. It was then repeated monthly, for a total of three months.

By the end, the subjects had decreased risk factors and biomarkers for aging, diabetes, and neurodegenerative and cardiovascular disease, without any major adverse effects and with just a few days of calorie restriction per month. The diet was also deliberately low in protein, but it’s hard to know whether the benefits seen were due to protein restriction, or calorie restriction in general. Independent of calorie restriction, protein restriction hasn’t yet proved beneficial in humans—quite the opposite, actually—and is likely a recipe for weight gain and muscle loss, especially over the long term.

The takeaway here is that aside from minding your meal timing, occasional low-calorie dieting may be useful for a long and healthy life. It makes sense from an evolutionary standpoint that our bodies would know what to do once food became scarce, since it’s unlikely our ancestors had successful hunts all year round.

Pick up a copy of Max’s book, The Genius Life, on or after March 17, 2020, or pre-order your copy today and get a number of generous freebies, including “The 10 Supplements for Better Brain Function.”

References

1. Les Dethlefsen et al., “The Pervasive Effects of an Antibiotic on the Human Gut Microbiota, as Revealed by Deep 16S rRNA Sequencing,” PLOS Biology 6, no. 11 (2008): e280, doi:10.1371/journal.pbio.0060280.

2. Tsepo Ramatla et al., “Evaluation of Antibiotic Residues in Raw Meat Using Different Analytical Methods,” Antibiotics 6.4 (2017): 34, doi:10.3390/antibiotics6040034; Khurram Muaz et al., “Antibiotic Residues in Chicken Meat: Global Prevalence, Threats, and Decontamination Strategies: A Review,” Journal of Food Protection 81, no. 4 (2018):619–27.

3. Marcin Bara?ski et al., “Higher Antioxidant and Lower Cadmium Concentrations and Lower Incidence of Pesticide Residues in Organically Grown Crops: A Systematic Literature Review and Meta-Analyses,” British Journal of Nutrition 112, no. 5 (2014):794–811.

4. Jotham Suez et al., “Post-antibiotic Gut Mucosal Microbiome Reconstitution Is Impaired by Probiotics and Improved by Autologous FMT,” Cell 174, no. 6 (2018): 1406–23.

5. Ruth E. Brown et al., “Secular Differences in the Association Between Caloric Intake, Macronutrient Intake, and Physical Activity with Obesity,” Obesity Research & Clinical Practice 10, no. 3 (2016): 243–55.

6. Tetsuhide Ito and Robert T. Jensen, “Association of Long-Term Proton Pump Inhibitor Therapy with Bone Fractures and Effects on Absorption of Calcium, Vitamin B12, Iron, and Magnesium,” Current Gastroenterology Reports 12, no. 6 (2010): 448–57, doi:10.1007/s11894-010-0141–0.

(function($) { $("#dfcC4o1").load("https://www.marksdailyapple.com/wp-admin/admin-ajax.php?action=dfads_ajax_load_ads&groups=674&limit=1&orderby=random&order=ASC&container_id=&container_html=none&container_class=&ad_html=div&ad_class=&callback_function=&return_javascript=0&_block_id=dfcC4o1" ); })( jQuery );

window.onload=function(){ga('send', { hitType: 'event', eventCategory: 'Ad Impression', eventAction: '94519' });}

The post How Fasting, Calorie Restriction, and a Fasting-Mimicking Diet Can Encourage Longevity appeared first on Mark's Daily Apple.

How Fasting, Calorie Restriction, and a Fasting-Mimicking Diet Can Encourage Longevity published first on https://drugaddictionsrehab.tumblr.com/

[wisepowder]

Pure Fisetin Powder: A Dietary Antioxidant In Aging and Longevity

Pure Fisetin Powder: A Dietary Antioxidant In Aging and Longevity

Flavonoid polyphenols are commonly used for their antioxidant properties. Their main source is fruits and vegetables that are consumed regularly, by millions worldwide. Due to their health benefits, flavonoids have also become key ingredients in different dietary supplements, especially resveratrol. Recent studies have found a new flavonoid namely fisetin, which is believed to be the most potent…

[cancersfakianakis1]

Cancers, Vol. 10, Pages 346: The “Yin and Yang” of Natural Compounds in Anticancer Therapy of Triple-Negative Breast Cancers

Cancers, Vol. 10, Pages 346: The “Yin and Yang” of Natural Compounds in Anticancer Therapy of Triple-Negative Breast Cancers

Cancers doi: 10.3390/cancers10100346

Authors: Elizabeth Varghese Samson Mathews Samuel Mariam Abotaleb Sohaila Cheema Ravinder Mamtani Dietrich Büsselberg

Among the different types of breast cancers, triple-negative breast cancers (TNBCs) are highly aggressive, do not respond to conventional hormonal/human epidermal growth factor receptor 2 (HER2)-targeted interventions due to the lack of the respective receptor targets, have chances of early recurrence, metastasize, tend to be more invasive in nature, and develop drug resistance. The global burden of TNBCs is increasing regardless of the number of cytotoxic drugs being introduced into the market each year as they have only moderate efficacy and/or unforeseen side effects. Therefore, the demand for more efficient therapeutic interventions, with reduced side effects, for the treatment of TNBCs is rising. While some plant metabolites/derivatives actually induce the risk of cancers, many plant-derived active principles have gained attention as efficient anticancer agents against TNBCs, with fewer adverse side effects. Here we discuss the possible oncogenic molecular pathways in TNBCs and how the purified plant-derived natural compounds specifically target and modulate the genes and/or proteins involved in these aberrant pathways to exhibit their anticancer potential. We have linked the anticancer potential of plant-derived natural compounds (luteolin, chalcones, piperine, deguelin, quercetin, rutin, fisetin, curcumin, resveratrol, and others) to their ability to target multiple dysregulated signaling pathways (such as the Wnt/β-catenin, Notch, NF-κB, PI3K/Akt/mammalian target of rapamycin (mTOR), mitogen-activated protein kinase (MAPK) and Hedgehog) leading to suppression of cell growth, proliferation, migration, inflammation, angiogenesis, epithelial-mesenchymal transition (EMT) and metastasis, and activation of apoptosis in TNBCs. Plant-derived compounds in combination with classical chemotherapeutic agents were more efficient in the treatment of TNBCs, possibly with lesser side effects.

https://ift.tt/2MRzzJs