#embryo development

[bpod-bpod]

Dance of Fate

The journey from the first cells of an embryo to the millions in an adult is complex and perilous, but it’s a story that happens time and again across individuals and species. Viewing the path they take is key to understanding how disease develops when cells take a wrong turn during development. To help track the journey researchers have created an atlas of cell movement and behaviour in the full process from zebrafish embryo to adult. The resource combines high resolution video of individual cells dividing and migrating during development (pictured) with complex data on which genes and molecules take hold at each stage to determine each cell’s fate. Unpicking the precise science behind this intricate dance and understanding how our cells fulfil their destiny could help us avoid disease and ensure we remain masters of our own.

Written by Anthony Lewis

Video from work by Merlin Lange and colleagues

Chan Zuckerberg Biohub, San Francisco, CA, USA

Video originally published with a Creative Commons Attribution 4.0 International (CC BY 4.0)

Published in Cell, November 2024

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[thepastisalreadywritten]

[the-commonplace-book]

Trump wants to enforce gender assignment at conception based on biological sex. AFAB and AMAB are out. Absolutely every single American will now be AFAC (assigned female at conception). Congrats on the gender.

[cascowriteswords]

[[this is a fic idea i'm currently fleshing out. i haven't written anything substantial in a loooong time but i'm trying to gain some momentum/motivation to write this🤞]]

A canon/fix-it [kinda?] story - Clarke and Lexa share a painful, unresolved history. Time has passed since they last saw each other, but echoes of their bond still haunt them both. Their story is one of deep longing, unspoken words, and the agonizing weight of silence.

[ahamkara-apologist]

Do you believe Lightbearers are changed biologically from before they became Lightbearers?

Can't believe I forgot to answer this- I genuinely thought I did until I was scrolling through my inbox and saw it pop up again. Oops.

Anyways, my headcanon is that yes, Lightbearers are biologically different than non-Lightbearers- they become so when their ghost is rezzing them for the first time. During the first rez, their bodies are essentially restructured to better suit being a vessel of Light, with far greater phsyical resiliance, capacity, and overall durability being granted as a boon from the Traveler so that they're not torn to shreds when using even the most basal abilities. Even Lightless, they're still much stronger than a baseline human, they cannot age (their telomeres simply do not degrade and their DNA repair kit becomes more accurate, so they don't incur the gradual DNA loss/nonspecific remedies that lead to the maladies of old age), and they're still paracausally sensitive, even if their conduit for channeling the Light has been cut. Outside of the never-aging and paracasal-sensitivity thing, the effect isn't drastic, but they are still noticibly hardier than a person who'd never directly touched the light of the Traveler would be. Eris, Zavala, and Osiris could be beaten by a sufficiently strong mortal in an arm wrestling contest, for example, but they're all able to learn to use Darkness/walk off injuries with an ease that a Lightless mortal cannot.

After the first rez, additional permanant change is possible, but it requires either paracausal alteration (such as wounds created by Darkness, wounds that were earned and began healing in a no-light zone, or subconcious paracausal alteration, where the Guardian's own body rejects the touch of the Light), or deliberate ghost manipulation. I like to headcanon that by using the Light in much the same way that they would heal, Ghosts can learn to tweak parts of their guardian's bodies to be altered to their liking, which is a method by which transitioning post-rez occurs, in the instance that one was not an exo or did not medically transition before death. It's extremely delicate, but all they have to do is use their bond and the Light to go 'hey, you're missing something, you need to make more of this hormone or grow more of this tissue to fully heal', and bam, gender transed :) This fully depends on the skill of the ghost, however, so its a slow process even if it can theoretically lead to a full transition over time, and certain tissues can only atrophy so far before they need to be cut off. In the case of exos, all the ghosts need to do is block the mental disconnect between the body alterations and the perception of what those should be, and that's about it

[unopenablebox]

for reasons [did the 'taking classes' year of grad school in 2020/21 and was desperate not to be on zoom anymore] i only took 7/8 required credits for my phd when i was supposed to and now have to take a class. already kind of cringe and undignified given my advanced age in grad school years. but i couldn't even use it to take something like linalg that i actually need training in because it only counts toward my degree if it's a biology class. not only do i absolutely not need anyone to teach any biology topic to me at this point, because my job is to interpret and synthesize primary biology literature, but i also already took every even faintly relevant biology course in college, some of them twice, the majority of them at grad level with graduate students. and they were taught better and more effectively, because my undergraduate institution simply had better pedagogical practices than *** by basically any metric.

all of this has cashed out to me taking the paper-reading course about my field taught by one of my committee members, because it only meets once a week, i've read half the papers before, and it's graded on class participation which is my best stat. unfortunately, because it's taught by one of my committee members, i can't admit that i am taking it literally only for credit and would be capable of teaching the class given a couple of weeks to prep, and instead have to pretend that i am concerned about it meaningfully impairing my career that, while i have an encyclopedic knowledge of early embryonic development in flies and worms, i'm really more familiar with late embryonic development in mammals. this is requiring some contortions.

[moe-broey]

Beautiful family photo of my homunculi (various stages of development)

And Lulu.

[porcelainvino]

blaintana siblingsssss

[whewchilly]

[kradogsrats]

@its-leethee I felt weird reblogging my own huge post for this lmao

I'm totally willing to accept all of that without question (Christian upbringing, I guess?) but what melts my brain out my ears is if Harrow and Viren had swapped bodies, would Viren's dark magic corruption stay with his body, or with his spirit/essence?

I mean, that and "wait why does the coin spell appear to literally draw the spirit out of the body, but then the body also disappears"

[bpod-bpod]

Lead the Follower

Computer modelling collective cell migration – such as occurs in wound healing, embryo development and cancer invasion – reveals the contributions to the speed of migration made by characteristics of the cells of the leader and follower rows

Read the published research article here

Video from work by Tien Comlekoglu and colleagues

Department of Cell Biology, University of Virginia, Charlottesville, VA, USA

Image originally published with a Creative Commons Attribution 4.0 International (CC BY 4.0)

Published in Biology Open, September 2024

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[my-autism-adhd-blog]

This is where the REAL Clone Wars starts.

Seriously though this so weird and it doesn’t sound like good idea…

[cadburycreampie]

Trump is pushing the sissyfication of America agenda with the whole “female at conception” thing. You are all ladies now by his legal definition

[ntls-24722]

fun drohnen fact: they love to fight. They will fight eachother for whatever reason but interestingly it actually deescalates most things 80% of the time. Disputes will generally have the two parties beat the crap out of eachother and in the winded daze afterwards they'll come to agreement and for this reason, their politics is insane and politicians oftentimes leap over their counters to beat the shit out of their opponents and nobody does anything about it because, well, it'll probably chill them out OR they'll agree on something.

This is, weirdly enough, probably because fighting is also a little romantic. Since Drohnen residents are all only One Sex and kids are expensive little tots who grow up to be the size of buildings, only one of them have the kid and that is generally decided on whoever loses/falls over (Drohnen pregnancies are WAY less scary than human ones, especially because they're used to laying eggs every 3 months - the loser generally doesn't mind it.).

Sometimes it's seen as a little suspicious when a fight lasts too short since romantic fighting is generally shorter than most fighting. much to the dismay of politicians trying to wrap up a squabble to get back to business

[whentherewerebicycles]

no baby for me.

[kaiyonohime]

Of the three eggs harvested last week, one has developed into a grade 4AA embryo. I have another appointment in two weeks to do more blood tests, get some more hormone injections, and setup the appointment for the transfer.