#deer gj

[unmeisenshi]

17.5 YEARS LATER

Arceus sensed the approaching planet Atropos, and looked at the meteor that traveled with them, the team fast asleep. Team Destiny was hard at work training for the upcoming fight. Their bodies were more toned, more battle hardened. Ann and Louis, both 17.5 years old, had evolved. Louis is now a Marowak, with light blue fur all over. He trained with his new blade, Yukianesa, and learned to fight using Iaijutsu. With Morello’s help, he even learned the Ride the Lightning technique that Zane once used.

Ann, meanwhile, evolved into a Charmeleon. She retains the cerulean blue flame and ice blue eyes from Karie and Solaris, as well as a strip of blue fur that travels from the bridge of her snout all the way to the tip of her tail. She and Solaris trained a lot together, developing their own “Hellfire” techniques and fighting style.

For Florence, Audie, Remi, and Morello - now aged 42, 37, 41, and 47 respectively - their bodies became thinner and more muscular, and each has honed their martial arts styles. The fur on their bodies has begun to turn gray, and Audie’s short hair on his head has become a brilliant silver color as opposed to white. Avett, now 45, didn’t change too much, but he’s learned plenty of healing spells from both Audie and Arceus, and has created what he calls Mach Zen along with the Espeon, using their magics to push their bodies to move even faster when using their Mach abilities.

Finally, Solaris - now age 43 - is much thinner. He has a strip of gray hair running from his head down his back, and has a short gray beard and whiskers, looking more like an eastern-style dragon. Thanks to a sneaky medicine that was snuck into his pack, his hand tremors have all but disappeared, allowing him to hone his drunken boxing style, as well as the new Hellfire style he and Ann use.

“Everyone… We are approaching Atropos. We are stopping to resupply.” Arceus gently said, speaking quietly enough for everyone to awaken.

Solaris stretched, and looked up at the deer God. He was going to ask a question, but a booming voice overhead interrupted his thought.

“Did you really think you’d move by without me knowing? Fools…” the voice chuckled. “Now, be good bugs and stay down when I squash you!”

Arceus saw it coming too late, as a large meteor collided with them. Thinking quickly, they contained the team in a bubble and held tightly onto them. “Everyone, hold on!” The God shouted as they began to enter the atmosphere of Atropos.

-

Down on the surface, a tribe of wild Pokemon watch the night sky, surrounded by giant trees and lush forests, when they see a giant silver fireball engulf the sky. The resulting sonic boom sends the Flying-types scurrying away. The tribe’s leader, a Quaquaval, watches intently as well. The silver coloring of the fireball made them frown. “Zappa… Is that you finally…?"

The loud boom from the impact certainly didn’t make this Quaquaval worry any less. “Dios mío… Let’s go and help them, amigos.”

-

LOCATION: Atropos

Atropos is a jungle planet, located at what we know now as planet GJ 1002b. The planet was long uninhabitable, but as the temperature of the nearby star rose, water eventually formed and life began on the planet. The Pokemon of the third Gaea found old shuttles once used by humans, and restored them to explore the stars, with one landing on Atropos. A base was set up, but its staff was killed off a few months after their arrival. The Pokemon on Atropos are divided into tribes that war and battle constantly, and all battles end with no concrete victor. 

[kwnnn]

Aan baizaarai bi eron dandaa depressdej irjee ene undurluguus harahad. Yahab odoo teriigee darah esvel martah neg argiig oljee. Gehdee tern butehguiee. Neeh butehguiee bishee gehdeeel mdhguee. Coping mechanism maani neg l buruu baih shig. Yhav nadad tusalj bgaach busdiig zovoogood bga yumshgee. Eeish uhaan orchoochdee chi bvr hzee neg sehee orood huuye gehinbee?

Zaza aliin bolgon chmg buruutgahvdee, gehdeell setgel gedeg togloom bish gej manai bi chamd hairtai-gn Bayraa ah goyoor helj bsndaa.

Eoo za ter yahvee bii ch ygd ch shunu untaj chdkuimaa, hzee neg hvn shig untaj hvn shig amidrahiin boldoo, yg ene ertontsiin haana n amidraad bainaa bvsgvi min🥲

Unuu Midori egch maani “Bvderch unaad uhaan oroosoi gej hvseh ch hvsleer min bolohgui yum aanai l nmg anzaarahgui chi hviten hundii hvn yumaa Watanabe..?” gej bsniig anh unshihdaa bi midori bailaa. Odoo jhn Watanabe bolood baigamuudaa.

Ugasa anhnasa chi uurigu evdleh hreggu l bsii hvn bolgond zvrhee siichuuleh hreggu bsin.

Tehde ngu talaraa aldaj baij uhaardag gdg shg nadad bvhnii utga uchriig medruulsn oilguulsn blhr ter bvhend haramsahguimdoo.

Bvderch unaj sehee oroh bolgondoo bvhnee uguud bval hzeech dahij gazraas bosohgu bsnshdee… Anhnasal bvderch unahgui yvahn zuwuu. Watanabe min chinii zuw. Gehdee Watanabe chn setgeln oilgomjtoi todorhoi zaluu bsnldaa.

Huurhido yvj2 bi chin hamgiin iheer durgui Naoko bolood duusjaam bainadaa gej.

Hahah eoo gutsaj ugjiiinaaa nooorog devter dre saraachij bga aytai alj ugjiinoo.

Aan nre ghdee ih sonin shvv, hvnii hairiin hel gej ynz ynzaar ilreh yumdaa. Goy duu sonsood l hairlaltsah, esvel engertn erhelj hairlaltsah, esvel zugeerl hamt baihad l hairlaltsah…. Mash iheee. Gehdee bayrlalaa horwoo ertonts deer mash olon goy medremj goy vibe saihan zvils baidgiig medreed l yvjiigaa zaluu nas min hzeech btgi duusaasaii hehe

Zozo untloo hichneen ugluu ert bosoh ajiltai bsan ch 4,5 gj untaad ch hmagu ugluu bosood yvj chadna gj het ih uurtuu itgej amidarj bainadaa

[joylinda-hawks]

Look, the stone is written Mo Ya (stay forever). WOH, episode 24. ZZS, WKX and ZCL go to Siji Manor. The beautiful surroundings encourage hiking. Flowering trees soothe the mind and heart. ZZS talks about Siji Manor, about the fact that the flowers in this place bloom for four seasons and in each season they are different flowers. This is what makes Siji Manor amazing. ZZS is happy to inform ZCL about this. ZCL is delighted with the area. WKX also delights in the views, describing them colorfully. The rabbit's unexpected appearance causes WKX to promise ZCL that he will catch it after the boy calls him Uncle Wen twice. ZCL replies that they will call him the second champion. ZZS opposes rabbit hunting, claims it may be a descendant of one of the rabbits kept by his master's wife, so leave him alone. ZCL claims she had the same passions as his mother. ZZS added that his master's wife and Mrs. Bi had a heart for them and took care of the animals. Both ladies opposed the hunt. ZZS relates that one day his master and uncle Zhang decided to hunt a deer, and the young ZZS told the master's wife about it. The result was that the wife chased the master all over the mountain and finally beat him. ZCL replies that it was similar in his family, his father was often beaten by his mother. Soon, the three of them approach a waterfall with an inscription carved into the rock. ZZS told about the history of the creation of the inscription. That it was engraved by his master a month after his son was born. For each of the three travelers, the road to Siji Manor had a different meaning. For ZZS it was a way of redemption of his faults. For WKX, it was an attempt to find a place for themselves in a world beyond Ghost Valley. And for ZCL, he was hoping to find a new home and family. Each of these three people was haunted by their own demons. They didn't show it. Seemingly, all three of them were joyful, but the secrets they were hiding did not give peace. ZZS knew that it had to face the past. A past he was trying to escape from, but the more he wanted to do so, the more he realized that it was impossible. He had to face it and make a home for WKX and ZCL. WKX still couldn't admit who he had really become over the years. He was afraid that if he told the truth, ZZS and ZCL would not accept him, reject him and despise him. WKX believes that Siji Manor will be a safe place where he can further plan his revenge. ZCL just wants to receive some family warmth, spend time studying with someone who cares about him. This opening scene is visually beautiful and well acted. ZZH and GJ are excellent guardians for a boy without parents. They try to show that the place they are going to can be the perfect home.

[bayzire]

Negen gazraas sonsson medsen ishlel: hun hen negen ugc bga zuwulguugu uurtuu ugdug

Bi jishe n cmg tegwel dr dee ingewel deer dee edr gl helj bga bolowc dald uhamsartaa uurtuu l zuwulguu ugdug gj bga bhguyu

Odoo jishee n bi cmg oroi ajlaa taraad shuud ireed ugluu ert bosood usand ord garc bai gj bgaa c ern bdd uzhd bi uuru ugluu ert bosood usand ordog uu oroi ert untdag uu? Ingj bdhr humuus biy biyde zuwulguu ugc bgaa blwc dald uhamsartaa uurtuu l zuwulguu ugdug

Huuye bitgii batgaa shahaad bgaac gj helj bga hun yg ys yman dree uuruu shahdag hun bdiishd harin huuyee bitgii shahaad bai gsn hun harin c shahadgui bh jisheenii

Ucigdur uulzahdaa yg gantshan ter hunii ter uurclugdwul zgr bn bh tegwel ingene tegne ern saldiimuu bolidiimu gj bdool ghdee yg ugtaa bi ter huniig mynga hiceelged uurcluhguishd ter huniig uurcluh n mnii ajil bish shd

Bi hediiger tegeec ingeec gj heleed ter hun ndd sn hairtai blhr za uuclarai gj helj bga c etssiin dvnd uurclugduh eseh n ter hunii dur ter hunii sanaa bodol shd

Ingd bdhr bi aimr logic gui za

Herwee jaahn l logictoi handwal yun dr uujuu taiwan bdd yun dr iluu anhaarwal uurcluh ym bn gwl bi bg bhguyu

Bi uuriigu uurcluj cdna

Busad huniig bish

Uuriiguu

Zuwhun uuriiguu

Bi uuruu uurclugduud uuruu uuriguu zasaad bwl ter hun hndlaga awna shd

Ene logic giig gantsaara bhdaa aimr sn oilgodog c huntei hariltsah uydee martaad bh ym tolgoi tiim muutai ym bhda

Herwee bi uneheer uuru hariutslagatai uuriin uzel bdloo barimtaldg bwl ter hun c mnii uzel bdliig barimtlna

Ene ug bol jinken unen sanagddg sn bdd uzwl bi tiim humuustei niilmeer bn nzuudtaigaa gy baiy ghr nzud mungugu mungutei nztai blhr ben edr gj bdl ghde bi uuru ym tiim mungutei end tendgui tsatsdg hun mun uu

Bi munguu uuru bodlogotoi ashiglaj cddg hun mun uu

Tgd bish bol ygd tiim hunuusteo nzly gj bdd bgaa ym uuruu tiim bolooc

Zgr l sn sana bi bi geese uur hun uurcluhgui cdhgui

[khaliunbe]

Ah duu hamaatan sadan, naiz nuhud, etseg eh boloogui etseg ehiin nz nuhud nmg tanidg bas tanidggui tr humuus namaig yu gj bodoh bol, yu gj harah bol, yu gj yrih bol gdgees hamaarch uuriin yvah zamaas hazaij, tuurch budilch, tendeee teegelj gatsaj, ed hurungutei, erh medeltei, ner hundtei bolj busdad tuuniige haruulj sain bgaagaa medruulehiig hicheeeseer baital jinhenesee sain saihan amidrah, ed baylagiin orond erh chuluutei, erh medliin orond erch huchtei, ner hundiin orond namaig gesen tsuuhun heden humuuseere hureeluulsen "Dulaahan, Gereltei" durtai zuilee hiij uuriin gesen itgel unemshilteigeer amidrah amidraliin horom hasagdsaar l baigaa. Tegeed ingej amidrahaar ur huuhdedee yu uldeeh ve gju? Uv hurungu uldehgui hze neg udur duusna, hrin iim amidral iluu une tsenetei baidg gdgiig haruulj oilguulaad uuriinhuuruu jargaltai baih itgel unemshiliig uldeegeed odson deer bizde.

[letsyukanathings]

bi uug ni anh enen deer goy ym bichne gj neej bilee ali jiliin umnu 

[dramauricaversan]

NAD+ IV Therapy for Lyme Symptoms: What is Nicotinamide Adenine Dinucleotide (NAD+)?

NAD+ intravenous (IV) therapy offers hope as a treatment for those with chronic conditions, including Lyme disease (Borrelia burgdorferi).

Lyme disease is a chronic disease that is transmitted to humans when infected black legged ticks (known as deer ticks) bite the skin and subsequently embed themselves.

Even after antibiotic treatments, people diagnosed with Lyme may continue to report debilitating symptoms such as joint pain, fatigue, weakness, brain fog, inflammation and neurological symptoms.

Nicotinamide Adenine Dinucleotide (NAD+) is a coenzyme found naturally in all the cells of the body and is integrated in various functions. It is a vitamin B3 (niacin) derivative that plays a vital role in energy production within the cells.

Studies have shown that NAD+ declines with age. As the natural aging process kicks in, the body fails to synthesize new NAD+ and the body may struggle to recycle NAD+ in the cells.

It is also believed that NAD+ levels decline in the presence of chronic diseases, including Lyme. Inflammation may result from chronic diseases because oxidative stress tends to increase in the body. However, research shows that intravenous NAD+ therapies or oral treatments of NAD+ precursors show promise in alleviating Lyme symptoms.

NAD+ IV therapy for Lyme symptoms

According to research from 2015, oxidative stress is suggested to be a potential result of the Lyme disease pathogen. Oxidative stress can trigger chronic inflammation symptoms because it elicits an immune system response to chronic pathogens (i.e. the bacteria that causes Lyme disease, Borrelia burgdorferi). Furthermore, oxidative damage ensues to proteins, DNA, and lipids, which have been linked to various chronic diseases (i.e. Lyme disease, chronic fatigue syndrome, cancer, Parkinson’s, Alzheimer’s and atherosclerosis).

During this particular 2015 study, a high build-up of mitochondrial superoxides – a free radical that contributes to oxidative stress – was found in those with Lyme when compared to the control group. This has led to the hypothesis that mitochondrial dysfunction takes place in Lyme disease and, therefore, NAD+ levels are depleted.

Today, many integrative functional medicine practitioners help restore NAD+ levels in Lyme patients intravenously to alleviate oxidative stress and help manage inflammation.

NAD+ mechanism of action: How does it help alleviate Lyme symptoms?

NAD+ IV therapy may benefit patients with Lyme disease in these ways:

NAD+ contributes to the formation of adenosine triphosphate (ATP), the unit in which we measure energy in the living cells.

Data suggests that NAD+ IV therapy may improve the cognitive function of individuals with chronic conditions, including Lyme disease.

NAD+ may help a person feel less tired; this may contribute to the overall well-being of the mitochondria, which are like tiny energy-producing factories in your cells. Scientists suggest that chronic diseases contain mitochondrial dysfunction in their physiopathology.

NAD+ IV therapy may improve your mood and cognitive functions by helping your brain create additional neurotransmitters.

Should you try NAD+ IV therapy to help treat Lyme symptoms?

Are you concerned that you’ve been exposed to infected black legged ticks? Or do you want to learn more about natural ways to alleviate Lyme symptoms?

At our Toronto-based clinic, Dr Amauri Caversan, ND, and Arv Buttar, NP, are available to help their patients with integrative and functional medicine programs. Our NAD+ IV therapy program, a part of the integrative treatment approach for lyme disease, may help assist the body in restoring neuroreceptor function to an optimal level. This program may also promote improved sleep, detoxification, cell health replenishment and physical and mental longevity. Book your appointment today – click here to send us a message.

References

Barbosa JA, Sivaraman J, Li Y, et al. Mechanism of action and NAD+-binding mode revealed by the crystal structure of L-histidinol dehydrogenase. Proc Natl Acad Sci U S A. 2002;99(4):1859-1864. doi:10.1073/pnas.022476199

Fang EF, Lautrup S, Hou Y, et al. NAD+ in Aging: Molecular Mechanisms and Translational Implications. Trends Mol Med. 2017;23(10):899-916. doi:10.1016/j.molmed.2017.08.001

Massudi H, Grant R, Braidy N, Guest J, Farnsworth B, Guillemin GJ. Age-associated changes in oxidative stress and NAD+ metabolism in human tissue. PLoS One. 2012;7(7):e42357. doi:10.1371/journal.pone.0042357

Pall ML. Common etiology of posttraumatic stress disorder, fibromyalgia, chronic fatigue syndrome and multiple chemical sensitivity via elevated nitric oxide/peroxynitrite. Med Hypotheses. 2001;57(2):139-145. doi:10.1054/mehy.2001.1325

Peacock BN, Gherezghiher TB, Hilario JD, Kellermann GH. New insights into Lyme disease. Redox Biol. 2015;5:66-70. doi:10.1016/j.redox.2015.03.002

“Pharmacy Compounding Committee Review: Nicotinamide Adenine Dinucleotide (NAD+)” viewed on September 3, 2020.

Pohanka M. Role of oxidative stress in infectious diseases. A review. Folia Microbiol (Praha). 2013;58(6):503-513. doi:10.1007/s12223-013-0239-5

Rajman L, Chwalek K, Sinclair DA. Therapeutic Potential of NAD-Boosting Molecules: The In Vivo Evidence. Cell Metab. 2018;27(3):529-547. doi:10.1016/j.cmet.2018.02.011

Zhu XH, Lu M, Lee BY, Ugurbil K, Chen W. In vivo NAD assay reveals the intracellular NAD contents and redox state in healthy human brain and their age dependences. Proc Natl Acad Sci U S A. 2015;112(9):2876-2881. doi:10.1073/pnas.1417921112

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[vnuxo]

hahahah deer ued ene balaig goy gj bddog blashd

[jimbobsonofriber]

How My City Is Going - 2

Disclaimer: All estate names and sizes are purely based on random rememberings and pun opportunity, and have no bearing on personal preferences or relationships. I love you all.

The Mas Production estate was the first big industrial estate, and, although the industrial sector has decreased due to the skill set of the city’s population, it has actually grown to encompass the rubbish-incineration plants - the only non-green power source in the city. Also, sometimes, it’s on fire.

The EofGizmo estate demonstrates my  inability to fit building zones in small areas. However, you can see the nice pedestrial bridges I made. All of the gridroads are named after staff members of the publication that formed this forum. At the back, the Kittsy Bypass is visible. It was originally part of the city’s grid system, but alien commuters used the road to travel between the motorways in the north and south of the city, clogging up the traffic, so it had to become a bypass.

Treesmurf Farms - farmland, but in a modern city! It’s got piggies! And a tractor! The demand for farms is decreasing, and there’s a larger farm to the north of the city, so it may be that, in future, this becomes a trendy gentrified housing estate.

Crumpyland contains the south part of the city’s facilities - medical centres, the police station etc., as well as a schamncy plaza. Look how many people are waiting for a bus! If they were going the other way, they’d have a choice of two... that were merging together.

Athrunshore has a graveyard opposite the local high school - that’ll get the kids to behave. Soon you’ll be dead. There’s also the stunning opera house, accessible from the ring road. Although, stupid arsehole that I am, drew the one-way system the wrong way round, so you have to cross over the junction as you enter or leave.

Kerwinton is the place for the Chozo High School, where all budding bird-like things go to learn Morph Balls and Food Technology. Behind that, you can see the attempt to organise the motorway, and the more recently added rail network, with a bridge system that’s asking for trouble. It’s a bit roller-coaster-y.

The Axis Axis. Axis made a mistake of saying he liked Repton once, so there’s a Repton street. This is one of the narrow estates in the north-east, and is, apart from this playground, jam-packed with houses.

The Beemoh memorial. Uh, Beemoh isn’t dead, so that sounds bad. Also ignore that skull and crossbones. That means someone else has died. And the hearse hasn’t arrived yet. Grim. Also, this is a shopping street. Why’s a body being stored there?

This is just wind farms..

Musselbury is home of The M - a giant hypermarket, full of outlets for all of your favourite brands. They’ve got Zenator. They’ve got Sternberger. The’ve got... *squints* Schwarzenecfer?

Dusty Knackerford is another little factory estate. Doing quite well, looking at all of those shipping containers. Also, in the top-left - that’s the motorway. There really should  be some barriers on that thing.

Silver Heights is full of swanky offices. It’s got its own underground station and everything. Hop on the Kid Kat line, and you’ll be in another part of the city in no time.

Balla Deer Woods was designed to be a nature reserve. So, there are very few houses, and everything was built without the need to chop down a single tree. Therefore, i’s immensely impractical.

Shanksbury nearly went the way of the dodo; however, now that it has its own rail depot (at the cost of a snaking monstrosity of a train track) it’s picked up quite nicely. Those icons do indicate that there can only be a finite lifespan, however...

This time, Duckburg is not on fire. A group of kids waits at the bus stop, to be taken home after a long school day. However, the busses that have arrived seem to have arsed everything right up.

Ooh, it’s the Grant Jones Business Park! This is the bit we show off when visitors come. It’s got a train station on the national network, an underground station, and a fancy schmancy exhibition centre.

Mandlebury is an industrial estate in the middle of the town, which wasn’t very clever of me. However you can see the super-aerial rail network. If you’re a bit funny with heights, you might want to get a bus.

If you wish to save your friend, solve my maze. I couldn’t do the green hoops, I’m afraid.

Oldskool corner also suffers from north-east syndrome; it’s a bit long and thin. However, the centre block has loads of luxury apartments. I’m not responsible for the parking spaces that are completely inaccessible.

Here’s the view from above Fronk Park#s Fronk University. We’ve got a university! Therefore the student digs along the quayside are mega expensive to let.

Ah, the suburban coziness of Drunkalilly. The green bus drivers are often asked: Do they know... Kid For To A Road?

Cappuccino Square - it’s the heart of everything. The commercial powerhouse that funds the rest of the city. It’s got everything, benefiting from my terrible rail system, and with a volume traffic that the streets weren’t built to handle.

Jasterton is a nice suburban... suburb... with a big park in the middle. It incongruously straddles a major road, and the “road planner” has fiddled about with this several times, to avoid a complete standstill.

The Orange Rakoon etstate seems to hold an unsustainable amount of commercial buildings. Also visible: the X-Wing-style junctions onto the main road.

The Rum Rapture Estate contains the swanky tower that controls all of the city’s public transport nees. For some reason, this makes it a tourist hotspot. If you’re in upper management, you get a great view of Balla Deer Woods.

Moo Moo Meadows. This is probably too much farm. There’s a lot of derelict buildings there. But it does its own rail depot. Fun fact: there are Moo Moo references on two other estates.

The Alternative Account Estate, designed to fill a tiny narrow bit of space at the very north. You’ve got Hopkins Street, Horse Street, Sylveon Street - all your favourites.

Moyleston is the housing area for all the trendy young people, right in the middle of the city. This place is f***ing expensive.

Zero Circle has streets based on roundabouts. Because roundabouts are circles, which is a type of maths. Wasted edges aside, this actually works really well.

The Gwyn 400 estate hosts the city’s stadium; hence the traffic extravaganza. There’s so many pedestrians in that picture! There are also 4 yellow bus route busses, and 4 white bus route busses. That can’t be good. Also there’s another hearse at the bottom of screen, picking someone up from the shop. What is going on in the shops?

The Fancy Estate. It’s fancy. Those curved roads are completely unnecessary.

Lastly - for some reason - the place that started it all - the Stu the Great Estate. Having been established for a while, and being on the river, some of the houses are worth a lot. I was going to make the roads look like “SJ”. However, it came out as “GJ”. How confusing.

[jesseneufeld]

Dear Mark: Iron Followup

Last week’s post on iron levels got a big response and garnered a ton of questions from you guys. Today, I’m going to clarify a few things and answer as many questions as I can. First, do iron and ferritin levels mean different things for men and women? If so, how do those differences manifest? What about premenopausal women vs postmenopausal women? Second, what do we make of the fact that ferritin is also increased in times of inflammation? Is there a way to distinguish between elevated ferritin caused by inflammation and elevated ferritin caused by high iron? Third, is desiccated liver a good option for liver haters? And finally, I share some exciting plague news.

Let’s go:

Emma wrote:

I’d love to see more info on iron levels as they relate to men and women differently. I recently had an iron infusion for low ferretin, not thinking much would change I actually experienced so many positive effects I didn’t even know were coming my way. I’m less cold, no more afternoon fatigue, less hair falling out, no more random palpitations, improved restless leg syndrome and the number one big change is it improved anxiety levels – in fact my anxiety is now gone. The last two are due to a connection between iron and dopamine. I learnt that children with mental health issues are often treated for low ferretin where possible, elevating levels to around 100 showing positive results (would love to see literature on this), for me my ferretin went from 20 to 130 and its changed my life, at 31 I haven’t felt this good in years. Yay iron!

That’s awesome to hear. Yes, it’s important to stress the very basic essentiality of iron. Without it, we truly cannot produce energy. And since energy is the currency for everything that happens in the body, an iron deficiency makes everything start to fall apart.

As for gender and iron, there’s a lot to discuss.

A good portion of women with hemochromatosis never actually express it phenotypically, meaning their lab tests don’t show evidence of dysregulated iron metabolism or storage. According to one study of hemochromatosis homozygotes (people who inherited the mutation from both of their parents), being a woman makes it 16x more likely that your hereditary hemochromatosis won’t actually present as iron overload.

Another study found that among mostly-age-matched men (42 years) and women (39 years) with hemochromatosis, 78% of the men had iron overload while just 36% of the women had it. Iron overload was defined as transferrin saturation over 52% combined with ferritin levels of 300 ng/mL for men and 200 ng/mL for women.

High iron levels are more of an issue for postmenopausal women than premenopausal women. The latter group regularly sheds blood through menstruation, and if anything, they’re at a higher risk of low iron. Plus, estrogen is a key regulator of iron metabolism. As menopause sets in and estrogen diminishes, that regulation suffers.

For instance:

In postmenopausal Korean women, high ferritin levels predict metabolic syndrome and subclinical atherosclerosis.

High ferritin predicts metabolic syndrome in postmenopausal but not premenopausal women.

In premenopausal Korean women, higher ferritin levels predict better bone mineral density; menopause nullifies this relationship.

Remember that ferritin is actually a measurable protein bound to iron, so testing a ferritin level is technically an indirect way to measure iron. Why is this important? Another characteristic of ferritin (the protein) is that it is an ACUTE PHASE REACTANT. This means that ferritin levels can fluctuate with illnesses and other inflammatory states in the body that drive up a ferritin value that is not related to an actual iron level fluctuation. Don’t get ferritin checked when you are sick with a cold or other illness.

This is a great point.

Ferritin is marker of long term iron storage, but it’s also an acute phase reactant that up regulates in response to inflammation or oxidative stress.

If you want to be really careful, you should get a HS-CRP test—that measures your overall inflammatory status. If CRP is elevated, ferritin can be elevated without saying anything about your iron status.

Come to think of it, if elevated ferritin can be a marker of inflammation and oxidative stress, the inflammation could be responsible for some of the negative health effects linked to high ferritin. Or, if having too much iron in the body can increase oxidative damage, it may be that high iron levels are increasing inflammation which in turn increases ferritin even further. Biology gets messy. Lots of feedback loops. However, the fact that many studies cited in the previous iron post that use blood donation to treat high ferritin have positive results indicates that for most people, ferritin can be, in most situations, an accurate estimation of your iron status.

To make sure it’s an iron problem, get a transferrin saturation test as well. That indicates the amount of iron you’re absorbing, with below 20% being low and over 45% being high. People with high ferritin and high transferrin saturation do have high iron levels. People whose ferritin is artificially enhanced by inflammation will have normal transferrin saturation levels.

I have one last question on this. You say “Don’t stop eating liver every week.” If you can’t stand the taste of liver, what do you think about taking liver capsules made from grass-fed New Zealand beef every day instead?

That’s a great option. Go for it.

People should generally aim for 4-8 ounces of fresh liver a week. Note the amount of desiccated liver in your capsules and multiply by 3 to get the fresh liver equivalent, then take enough each day (or all at once) to hit 4-8 ounces over the week. I hear good things about this one.

Mark, Thank you for your article on HH. I carry the gene but have been managing my iron levels through phlebotomies. I am full Keto, meat and all and have found my iron levels have not been effected by going Keto. Early detection is the key and ongoing monitoring. Bring on the plague!!!

You joke about that now, but there’s a startup that’s breeding heritage rat fleas that produce a mild strain of the plague that evades the attention of the immune system and proliferates throughout the body to keep iron levels in check without killing you. I’m an early investor, have a couple swarms installed in my condo, and (knock on wood) so far have avoided anything worse than a sore throat and maybe a mild open sore or two. There’s actually a big rift forming between the techs who want to keep the fleas heritage and those who want to go ahead with CRISPR and engineer them. One variant has had a deer tick gene inserted that adds an anesthetic compound to the flea’s saliva. That way you can have a personal swarm on you and never feel any bites or itches.

I’m not sure about CRISPR just yet, but I gotta say it’s pretty nice to be covered in fleas and not feel the bites. Time will tell.

Ok, I’m joking.

That’s it for today, folks. I hope I’ve answered some of your concerns, and if not, let me know down below. Thanks for reading!

(function($) { $("#dfKg6Se").load("https://www.marksdailyapple.com/wp-admin/admin-ajax.php?action=dfads_ajax_load_ads&groups=674&limit=1&orderby=random&order=ASC&container_id=&container_html=none&container_class=&ad_html=div&ad_class=&callback_function=&return_javascript=0&_block_id=dfKg6Se" ); })( jQuery );

Want to make fat loss easier? Try the Definitive Guide for Troubleshooting Weight Loss for free here.

window.onload=function(){ga('send', { hitType: 'event', eventCategory: 'Ad Impression', eventAction: '65477' });}

References:

Lainé F, Jouannolle AM, Morcet J, et al. Phenotypic expression in detected C282Y homozygous women depends on body mass index. J Hepatol. 2005;43(6):1055-9.

Qian Y, Yin C, Chen Y, et al. Estrogen contributes to regulating iron metabolism through governing ferroportin signaling via an estrogen response element. Cell Signal. 2015;27(5):934-42.

Seo SK, Yun BH, Chon SJ, et al. Association of serum ferritin levels with metabolic syndrome and subclinical coronary atherosclerosis in postmenopausal Korean women. Clin Chim Acta. 2015;438:62-6.

Cho GJ, Shin JH, Yi KW, et al. Serum ferritin levels are associated with metabolic syndrome in postmenopausal women but not in premenopausal women. Menopause. 2011;18(10):1120-4.

Chon SJ, Choi YR, Roh YH, et al. Association between levels of serum ferritin and bone mineral density in Korean premenopausal and postmenopausal women: KNHANES 2008-2010. PLoS ONE. 2014;9(12):e114972.

The post Dear Mark: Iron Followup appeared first on Mark's Daily Apple.

Dear Mark: Iron Followup published first on https://drugaddictionsrehab.tumblr.com/

[cristinajourdanqp]

Dear Mark: Iron Followup

Last week’s post on iron levels got a big response and garnered a ton of questions from you guys. Today, I’m going to clarify a few things and answer as many questions as I can. First, do iron and ferritin levels mean different things for men and women? If so, how do those differences manifest? What about premenopausal women vs postmenopausal women? Second, what do we make of the fact that ferritin is also increased in times of inflammation? Is there a way to distinguish between elevated ferritin caused by inflammation and elevated ferritin caused by high iron? Third, is desiccated liver a good option for liver haters? And finally, I share some exciting plague news.

Let’s go:

Emma wrote:

I’d love to see more info on iron levels as they relate to men and women differently. I recently had an iron infusion for low ferretin, not thinking much would change I actually experienced so many positive effects I didn’t even know were coming my way. I’m less cold, no more afternoon fatigue, less hair falling out, no more random palpitations, improved restless leg syndrome and the number one big change is it improved anxiety levels – in fact my anxiety is now gone. The last two are due to a connection between iron and dopamine. I learnt that children with mental health issues are often treated for low ferretin where possible, elevating levels to around 100 showing positive results (would love to see literature on this), for me my ferretin went from 20 to 130 and its changed my life, at 31 I haven’t felt this good in years. Yay iron!

That’s awesome to hear. Yes, it’s important to stress the very basic essentiality of iron. Without it, we truly cannot produce energy. And since energy is the currency for everything that happens in the body, an iron deficiency makes everything start to fall apart.

As for gender and iron, there’s a lot to discuss.

A good portion of women with hemochromatosis never actually express it phenotypically, meaning their lab tests don’t show evidence of dysregulated iron metabolism or storage. According to one study of hemochromatosis homozygotes (people who inherited the mutation from both of their parents), being a woman makes it 16x more likely that your hereditary hemochromatosis won’t actually present as iron overload.

Another study found that among mostly-age-matched men (42 years) and women (39 years) with hemochromatosis, 78% of the men had iron overload while just 36% of the women had it. Iron overload was defined as transferrin saturation over 52% combined with ferritin levels of 300 ng/mL for men and 200 ng/mL for women.

High iron levels are more of an issue for postmenopausal women than premenopausal women. The latter group regularly sheds blood through menstruation, and if anything, they’re at a higher risk of low iron. Plus, estrogen is a key regulator of iron metabolism. As menopause sets in and estrogen diminishes, that regulation suffers.

For instance:

In postmenopausal Korean women, high ferritin levels predict metabolic syndrome and subclinical atherosclerosis.

High ferritin predicts metabolic syndrome in postmenopausal but not premenopausal women.

In premenopausal Korean women, higher ferritin levels predict better bone mineral density; menopause nullifies this relationship.

Remember that ferritin is actually a measurable protein bound to iron, so testing a ferritin level is technically an indirect way to measure iron. Why is this important? Another characteristic of ferritin (the protein) is that it is an ACUTE PHASE REACTANT. This means that ferritin levels can fluctuate with illnesses and other inflammatory states in the body that drive up a ferritin value that is not related to an actual iron level fluctuation. Don’t get ferritin checked when you are sick with a cold or other illness.

This is a great point.

Ferritin is marker of long term iron storage, but it’s also an acute phase reactant that up regulates in response to inflammation or oxidative stress.

If you want to be really careful, you should get a HS-CRP test—that measures your overall inflammatory status. If CRP is elevated, ferritin can be elevated without saying anything about your iron status.

Come to think of it, if elevated ferritin can be a marker of inflammation and oxidative stress, the inflammation could be responsible for some of the negative health effects linked to high ferritin. Or, if having too much iron in the body can increase oxidative damage, it may be that high iron levels are increasing inflammation which in turn increases ferritin even further. Biology gets messy. Lots of feedback loops. However, the fact that many studies cited in the previous iron post that use blood donation to treat high ferritin have positive results indicates that for most people, ferritin can be, in most situations, an accurate estimation of your iron status.

To make sure it’s an iron problem, get a transferrin saturation test as well. That indicates the amount of iron you’re absorbing, with below 20% being low and over 45% being high. People with high ferritin and high transferrin saturation do have high iron levels. People whose ferritin is artificially enhanced by inflammation will have normal transferrin saturation levels.

I have one last question on this. You say “Don’t stop eating liver every week.” If you can’t stand the taste of liver, what do you think about taking liver capsules made from grass-fed New Zealand beef every day instead?

That’s a great option. Go for it.

People should generally aim for 4-8 ounces of fresh liver a week. Note the amount of desiccated liver in your capsules and multiply by 3 to get the fresh liver equivalent, then take enough each day (or all at once) to hit 4-8 ounces over the week. I hear good things about this one.

Mark, Thank you for your article on HH. I carry the gene but have been managing my iron levels through phlebotomies. I am full Keto, meat and all and have found my iron levels have not been effected by going Keto. Early detection is the key and ongoing monitoring. Bring on the plague!!!

You joke about that now, but there’s a startup that’s breeding heritage rat fleas that produce a mild strain of the plague that evades the attention of the immune system and proliferates throughout the body to keep iron levels in check without killing you. I’m an early investor, have a couple swarms installed in my condo, and (knock on wood) so far have avoided anything worse than a sore throat and maybe a mild open sore or two. There’s actually a big rift forming between the techs who want to keep the fleas heritage and those who want to go ahead with CRISPR and engineer them. One variant has had a deer tick gene inserted that adds an anesthetic compound to the flea’s saliva. That way you can have a personal swarm on you and never feel any bites or itches.

I’m not sure about CRISPR just yet, but I gotta say it’s pretty nice to be covered in fleas and not feel the bites. Time will tell.

Ok, I’m joking.

That’s it for today, folks. I hope I’ve answered some of your concerns, and if not, let me know down below. Thanks for reading!

Want to make fat loss easier? Try the Definitive Guide for Troubleshooting Weight Loss for free here.

References:

Lainé F, Jouannolle AM, Morcet J, et al. Phenotypic expression in detected C282Y homozygous women depends on body mass index. J Hepatol. 2005;43(6):1055-9.

Qian Y, Yin C, Chen Y, et al. Estrogen contributes to regulating iron metabolism through governing ferroportin signaling via an estrogen response element. Cell Signal. 2015;27(5):934-42.

Seo SK, Yun BH, Chon SJ, et al. Association of serum ferritin levels with metabolic syndrome and subclinical coronary atherosclerosis in postmenopausal Korean women. Clin Chim Acta. 2015;438:62-6.

Cho GJ, Shin JH, Yi KW, et al. Serum ferritin levels are associated with metabolic syndrome in postmenopausal women but not in premenopausal women. Menopause. 2011;18(10):1120-4.

Chon SJ, Choi YR, Roh YH, et al. Association between levels of serum ferritin and bone mineral density in Korean premenopausal and postmenopausal women: KNHANES 2008-2010. PLoS ONE. 2014;9(12):e114972.

The post Dear Mark: Iron Followup appeared first on Mark's Daily Apple.

[milenasanchezmk]

Dear Mark: Iron Followup

Last week’s post on iron levels got a big response and garnered a ton of questions from you guys. Today, I’m going to clarify a few things and answer as many questions as I can. First, do iron and ferritin levels mean different things for men and women? If so, how do those differences manifest? What about premenopausal women vs postmenopausal women? Second, what do we make of the fact that ferritin is also increased in times of inflammation? Is there a way to distinguish between elevated ferritin caused by inflammation and elevated ferritin caused by high iron? Third, is desiccated liver a good option for liver haters? And finally, I share some exciting plague news.

Let’s go:

Emma wrote:

I’d love to see more info on iron levels as they relate to men and women differently. I recently had an iron infusion for low ferretin, not thinking much would change I actually experienced so many positive effects I didn’t even know were coming my way. I’m less cold, no more afternoon fatigue, less hair falling out, no more random palpitations, improved restless leg syndrome and the number one big change is it improved anxiety levels – in fact my anxiety is now gone. The last two are due to a connection between iron and dopamine. I learnt that children with mental health issues are often treated for low ferretin where possible, elevating levels to around 100 showing positive results (would love to see literature on this), for me my ferretin went from 20 to 130 and its changed my life, at 31 I haven’t felt this good in years. Yay iron!

That’s awesome to hear. Yes, it’s important to stress the very basic essentiality of iron. Without it, we truly cannot produce energy. And since energy is the currency for everything that happens in the body, an iron deficiency makes everything start to fall apart.

As for gender and iron, there’s a lot to discuss.

A good portion of women with hemochromatosis never actually express it phenotypically, meaning their lab tests don’t show evidence of dysregulated iron metabolism or storage. According to one study of hemochromatosis homozygotes (people who inherited the mutation from both of their parents), being a woman makes it 16x more likely that your hereditary hemochromatosis won’t actually present as iron overload.

Another study found that among mostly-age-matched men (42 years) and women (39 years) with hemochromatosis, 78% of the men had iron overload while just 36% of the women had it. Iron overload was defined as transferrin saturation over 52% combined with ferritin levels of 300 ng/mL for men and 200 ng/mL for women.

High iron levels are more of an issue for postmenopausal women than premenopausal women. The latter group regularly sheds blood through menstruation, and if anything, they’re at a higher risk of low iron. Plus, estrogen is a key regulator of iron metabolism. As menopause sets in and estrogen diminishes, that regulation suffers.

For instance:

In postmenopausal Korean women, high ferritin levels predict metabolic syndrome and subclinical atherosclerosis.

High ferritin predicts metabolic syndrome in postmenopausal but not premenopausal women.

In premenopausal Korean women, higher ferritin levels predict better bone mineral density; menopause nullifies this relationship.

Remember that ferritin is actually a measurable protein bound to iron, so testing a ferritin level is technically an indirect way to measure iron. Why is this important? Another characteristic of ferritin (the protein) is that it is an ACUTE PHASE REACTANT. This means that ferritin levels can fluctuate with illnesses and other inflammatory states in the body that drive up a ferritin value that is not related to an actual iron level fluctuation. Don’t get ferritin checked when you are sick with a cold or other illness.

This is a great point.

Ferritin is marker of long term iron storage, but it’s also an acute phase reactant that up regulates in response to inflammation or oxidative stress.

If you want to be really careful, you should get a HS-CRP test—that measures your overall inflammatory status. If CRP is elevated, ferritin can be elevated without saying anything about your iron status.

Come to think of it, if elevated ferritin can be a marker of inflammation and oxidative stress, the inflammation could be responsible for some of the negative health effects linked to high ferritin. Or, if having too much iron in the body can increase oxidative damage, it may be that high iron levels are increasing inflammation which in turn increases ferritin even further. Biology gets messy. Lots of feedback loops. However, the fact that many studies cited in the previous iron post that use blood donation to treat high ferritin have positive results indicates that for most people, ferritin can be, in most situations, an accurate estimation of your iron status.

To make sure it’s an iron problem, get a transferrin saturation test as well. That indicates the amount of iron you’re absorbing, with below 20% being low and over 45% being high. People with high ferritin and high transferrin saturation do have high iron levels. People whose ferritin is artificially enhanced by inflammation will have normal transferrin saturation levels.

I have one last question on this. You say “Don’t stop eating liver every week.” If you can’t stand the taste of liver, what do you think about taking liver capsules made from grass-fed New Zealand beef every day instead?

That’s a great option. Go for it.

People should generally aim for 4-8 ounces of fresh liver a week. Note the amount of desiccated liver in your capsules and multiply by 3 to get the fresh liver equivalent, then take enough each day (or all at once) to hit 4-8 ounces over the week. I hear good things about this one.

Mark, Thank you for your article on HH. I carry the gene but have been managing my iron levels through phlebotomies. I am full Keto, meat and all and have found my iron levels have not been effected by going Keto. Early detection is the key and ongoing monitoring. Bring on the plague!!!

You joke about that now, but there’s a startup that’s breeding heritage rat fleas that produce a mild strain of the plague that evades the attention of the immune system and proliferates throughout the body to keep iron levels in check without killing you. I’m an early investor, have a couple swarms installed in my condo, and (knock on wood) so far have avoided anything worse than a sore throat and maybe a mild open sore or two. There’s actually a big rift forming between the techs who want to keep the fleas heritage and those who want to go ahead with CRISPR and engineer them. One variant has had a deer tick gene inserted that adds an anesthetic compound to the flea’s saliva. That way you can have a personal swarm on you and never feel any bites or itches.

I’m not sure about CRISPR just yet, but I gotta say it’s pretty nice to be covered in fleas and not feel the bites. Time will tell.

Ok, I’m joking.

That’s it for today, folks. I hope I’ve answered some of your concerns, and if not, let me know down below. Thanks for reading!

Want to make fat loss easier? Try the Definitive Guide for Troubleshooting Weight Loss for free here.

References:

Lainé F, Jouannolle AM, Morcet J, et al. Phenotypic expression in detected C282Y homozygous women depends on body mass index. J Hepatol. 2005;43(6):1055-9.

Qian Y, Yin C, Chen Y, et al. Estrogen contributes to regulating iron metabolism through governing ferroportin signaling via an estrogen response element. Cell Signal. 2015;27(5):934-42.

Seo SK, Yun BH, Chon SJ, et al. Association of serum ferritin levels with metabolic syndrome and subclinical coronary atherosclerosis in postmenopausal Korean women. Clin Chim Acta. 2015;438:62-6.

Cho GJ, Shin JH, Yi KW, et al. Serum ferritin levels are associated with metabolic syndrome in postmenopausal women but not in premenopausal women. Menopause. 2011;18(10):1120-4.

Chon SJ, Choi YR, Roh YH, et al. Association between levels of serum ferritin and bone mineral density in Korean premenopausal and postmenopausal women: KNHANES 2008-2010. PLoS ONE. 2014;9(12):e114972.

The post Dear Mark: Iron Followup appeared first on Mark's Daily Apple.

[fishermariawo]

Dear Mark: Iron Followup

Last week’s post on iron levels got a big response and garnered a ton of questions from you guys. Today, I’m going to clarify a few things and answer as many questions as I can. First, do iron and ferritin levels mean different things for men and women? If so, how do those differences manifest? What about premenopausal women vs postmenopausal women? Second, what do we make of the fact that ferritin is also increased in times of inflammation? Is there a way to distinguish between elevated ferritin caused by inflammation and elevated ferritin caused by high iron? Third, is desiccated liver a good option for liver haters? And finally, I share some exciting plague news.

Let’s go:

Emma wrote:

I’d love to see more info on iron levels as they relate to men and women differently. I recently had an iron infusion for low ferretin, not thinking much would change I actually experienced so many positive effects I didn’t even know were coming my way. I’m less cold, no more afternoon fatigue, less hair falling out, no more random palpitations, improved restless leg syndrome and the number one big change is it improved anxiety levels – in fact my anxiety is now gone. The last two are due to a connection between iron and dopamine. I learnt that children with mental health issues are often treated for low ferretin where possible, elevating levels to around 100 showing positive results (would love to see literature on this), for me my ferretin went from 20 to 130 and its changed my life, at 31 I haven’t felt this good in years. Yay iron!

That’s awesome to hear. Yes, it’s important to stress the very basic essentiality of iron. Without it, we truly cannot produce energy. And since energy is the currency for everything that happens in the body, an iron deficiency makes everything start to fall apart.

As for gender and iron, there’s a lot to discuss.

A good portion of women with hemochromatosis never actually express it phenotypically, meaning their lab tests don’t show evidence of dysregulated iron metabolism or storage. According to one study of hemochromatosis homozygotes (people who inherited the mutation from both of their parents), being a woman makes it 16x more likely that your hereditary hemochromatosis won’t actually present as iron overload.

Another study found that among mostly-age-matched men (42 years) and women (39 years) with hemochromatosis, 78% of the men had iron overload while just 36% of the women had it. Iron overload was defined as transferrin saturation over 52% combined with ferritin levels of 300 ng/mL for men and 200 ng/mL for women.

High iron levels are more of an issue for postmenopausal women than premenopausal women. The latter group regularly sheds blood through menstruation, and if anything, they’re at a higher risk of low iron. Plus, estrogen is a key regulator of iron metabolism. As menopause sets in and estrogen diminishes, that regulation suffers.

For instance:

In postmenopausal Korean women, high ferritin levels predict metabolic syndrome and subclinical atherosclerosis.

High ferritin predicts metabolic syndrome in postmenopausal but not premenopausal women.

In premenopausal Korean women, higher ferritin levels predict better bone mineral density; menopause nullifies this relationship.

Remember that ferritin is actually a measurable protein bound to iron, so testing a ferritin level is technically an indirect way to measure iron. Why is this important? Another characteristic of ferritin (the protein) is that it is an ACUTE PHASE REACTANT. This means that ferritin levels can fluctuate with illnesses and other inflammatory states in the body that drive up a ferritin value that is not related to an actual iron level fluctuation. Don’t get ferritin checked when you are sick with a cold or other illness.

This is a great point.

Ferritin is marker of long term iron storage, but it’s also an acute phase reactant that up regulates in response to inflammation or oxidative stress.

If you want to be really careful, you should get a HS-CRP test—that measures your overall inflammatory status. If CRP is elevated, ferritin can be elevated without saying anything about your iron status.

Come to think of it, if elevated ferritin can be a marker of inflammation and oxidative stress, the inflammation could be responsible for some of the negative health effects linked to high ferritin. Or, if having too much iron in the body can increase oxidative damage, it may be that high iron levels are increasing inflammation which in turn increases ferritin even further. Biology gets messy. Lots of feedback loops. However, the fact that many studies cited in the previous iron post that use blood donation to treat high ferritin have positive results indicates that for most people, ferritin can be, in most situations, an accurate estimation of your iron status.

To make sure it’s an iron problem, get a transferrin saturation test as well. That indicates the amount of iron you’re absorbing, with below 20% being low and over 45% being high. People with high ferritin and high transferrin saturation do have high iron levels. People whose ferritin is artificially enhanced by inflammation will have normal transferrin saturation levels.

I have one last question on this. You say “Don’t stop eating liver every week.” If you can’t stand the taste of liver, what do you think about taking liver capsules made from grass-fed New Zealand beef every day instead?

That’s a great option. Go for it.

People should generally aim for 4-8 ounces of fresh liver a week. Note the amount of desiccated liver in your capsules and multiply by 3 to get the fresh liver equivalent, then take enough each day (or all at once) to hit 4-8 ounces over the week. I hear good things about this one.

Mark, Thank you for your article on HH. I carry the gene but have been managing my iron levels through phlebotomies. I am full Keto, meat and all and have found my iron levels have not been effected by going Keto. Early detection is the key and ongoing monitoring. Bring on the plague!!!

You joke about that now, but there’s a startup that’s breeding heritage rat fleas that produce a mild strain of the plague that evades the attention of the immune system and proliferates throughout the body to keep iron levels in check without killing you. I’m an early investor, have a couple swarms installed in my condo, and (knock on wood) so far have avoided anything worse than a sore throat and maybe a mild open sore or two. There’s actually a big rift forming between the techs who want to keep the fleas heritage and those who want to go ahead with CRISPR and engineer them. One variant has had a deer tick gene inserted that adds an anesthetic compound to the flea’s saliva. That way you can have a personal swarm on you and never feel any bites or itches.

I’m not sure about CRISPR just yet, but I gotta say it’s pretty nice to be covered in fleas and not feel the bites. Time will tell.

Ok, I’m joking.

That’s it for today, folks. I hope I’ve answered some of your concerns, and if not, let me know down below. Thanks for reading!

Want to make fat loss easier? Try the Definitive Guide for Troubleshooting Weight Loss for free here.

References:

Lainé F, Jouannolle AM, Morcet J, et al. Phenotypic expression in detected C282Y homozygous women depends on body mass index. J Hepatol. 2005;43(6):1055-9.

Qian Y, Yin C, Chen Y, et al. Estrogen contributes to regulating iron metabolism through governing ferroportin signaling via an estrogen response element. Cell Signal. 2015;27(5):934-42.

Seo SK, Yun BH, Chon SJ, et al. Association of serum ferritin levels with metabolic syndrome and subclinical coronary atherosclerosis in postmenopausal Korean women. Clin Chim Acta. 2015;438:62-6.

Cho GJ, Shin JH, Yi KW, et al. Serum ferritin levels are associated with metabolic syndrome in postmenopausal women but not in premenopausal women. Menopause. 2011;18(10):1120-4.

Chon SJ, Choi YR, Roh YH, et al. Association between levels of serum ferritin and bone mineral density in Korean premenopausal and postmenopausal women: KNHANES 2008-2010. PLoS ONE. 2014;9(12):e114972.

The post Dear Mark: Iron Followup appeared first on Mark's Daily Apple.

[watsonrodriquezie]

Dear Mark: Iron Followup

Last week’s post on iron levels got a big response and garnered a ton of questions from you guys. Today, I’m going to clarify a few things and answer as many questions as I can. First, do iron and ferritin levels mean different things for men and women? If so, how do those differences manifest? What about premenopausal women vs postmenopausal women? Second, what do we make of the fact that ferritin is also increased in times of inflammation? Is there a way to distinguish between elevated ferritin caused by inflammation and elevated ferritin caused by high iron? Third, is desiccated liver a good option for liver haters? And finally, I share some exciting plague news.

Let’s go:

Emma wrote:

I’d love to see more info on iron levels as they relate to men and women differently. I recently had an iron infusion for low ferretin, not thinking much would change I actually experienced so many positive effects I didn’t even know were coming my way. I’m less cold, no more afternoon fatigue, less hair falling out, no more random palpitations, improved restless leg syndrome and the number one big change is it improved anxiety levels – in fact my anxiety is now gone. The last two are due to a connection between iron and dopamine. I learnt that children with mental health issues are often treated for low ferretin where possible, elevating levels to around 100 showing positive results (would love to see literature on this), for me my ferretin went from 20 to 130 and its changed my life, at 31 I haven’t felt this good in years. Yay iron!

That’s awesome to hear. Yes, it’s important to stress the very basic essentiality of iron. Without it, we truly cannot produce energy. And since energy is the currency for everything that happens in the body, an iron deficiency makes everything start to fall apart.

As for gender and iron, there’s a lot to discuss.

A good portion of women with hemochromatosis never actually express it phenotypically, meaning their lab tests don’t show evidence of dysregulated iron metabolism or storage. According to one study of hemochromatosis homozygotes (people who inherited the mutation from both of their parents), being a woman makes it 16x more likely that your hereditary hemochromatosis won’t actually present as iron overload.

Another study found that among mostly-age-matched men (42 years) and women (39 years) with hemochromatosis, 78% of the men had iron overload while just 36% of the women had it. Iron overload was defined as transferrin saturation over 52% combined with ferritin levels of 300 ng/mL for men and 200 ng/mL for women.

High iron levels are more of an issue for postmenopausal women than premenopausal women. The latter group regularly sheds blood through menstruation, and if anything, they’re at a higher risk of low iron. Plus, estrogen is a key regulator of iron metabolism. As menopause sets in and estrogen diminishes, that regulation suffers.

For instance:

In postmenopausal Korean women, high ferritin levels predict metabolic syndrome and subclinical atherosclerosis.

High ferritin predicts metabolic syndrome in postmenopausal but not premenopausal women.

In premenopausal Korean women, higher ferritin levels predict better bone mineral density; menopause nullifies this relationship.

Remember that ferritin is actually a measurable protein bound to iron, so testing a ferritin level is technically an indirect way to measure iron. Why is this important? Another characteristic of ferritin (the protein) is that it is an ACUTE PHASE REACTANT. This means that ferritin levels can fluctuate with illnesses and other inflammatory states in the body that drive up a ferritin value that is not related to an actual iron level fluctuation. Don’t get ferritin checked when you are sick with a cold or other illness.

This is a great point.

Ferritin is marker of long term iron storage, but it’s also an acute phase reactant that up regulates in response to inflammation or oxidative stress.

If you want to be really careful, you should get a HS-CRP test—that measures your overall inflammatory status. If CRP is elevated, ferritin can be elevated without saying anything about your iron status.

Come to think of it, if elevated ferritin can be a marker of inflammation and oxidative stress, the inflammation could be responsible for some of the negative health effects linked to high ferritin. Or, if having too much iron in the body can increase oxidative damage, it may be that high iron levels are increasing inflammation which in turn increases ferritin even further. Biology gets messy. Lots of feedback loops. However, the fact that many studies cited in the previous iron post that use blood donation to treat high ferritin have positive results indicates that for most people, ferritin can be, in most situations, an accurate estimation of your iron status.

To make sure it’s an iron problem, get a transferrin saturation test as well. That indicates the amount of iron you’re absorbing, with below 20% being low and over 45% being high. People with high ferritin and high transferrin saturation do have high iron levels. People whose ferritin is artificially enhanced by inflammation will have normal transferrin saturation levels.

I have one last question on this. You say “Don’t stop eating liver every week.” If you can’t stand the taste of liver, what do you think about taking liver capsules made from grass-fed New Zealand beef every day instead?

That’s a great option. Go for it.

People should generally aim for 4-8 ounces of fresh liver a week. Note the amount of desiccated liver in your capsules and multiply by 3 to get the fresh liver equivalent, then take enough each day (or all at once) to hit 4-8 ounces over the week. I hear good things about this one.

Mark, Thank you for your article on HH. I carry the gene but have been managing my iron levels through phlebotomies. I am full Keto, meat and all and have found my iron levels have not been effected by going Keto. Early detection is the key and ongoing monitoring. Bring on the plague!!!

You joke about that now, but there’s a startup that’s breeding heritage rat fleas that produce a mild strain of the plague that evades the attention of the immune system and proliferates throughout the body to keep iron levels in check without killing you. I’m an early investor, have a couple swarms installed in my condo, and (knock on wood) so far have avoided anything worse than a sore throat and maybe a mild open sore or two. There’s actually a big rift forming between the techs who want to keep the fleas heritage and those who want to go ahead with CRISPR and engineer them. One variant has had a deer tick gene inserted that adds an anesthetic compound to the flea’s saliva. That way you can have a personal swarm on you and never feel any bites or itches.

I’m not sure about CRISPR just yet, but I gotta say it’s pretty nice to be covered in fleas and not feel the bites. Time will tell.

Ok, I’m joking.

That’s it for today, folks. I hope I’ve answered some of your concerns, and if not, let me know down below. Thanks for reading!

Want to make fat loss easier? Try the Definitive Guide for Troubleshooting Weight Loss for free here.

References:

Lainé F, Jouannolle AM, Morcet J, et al. Phenotypic expression in detected C282Y homozygous women depends on body mass index. J Hepatol. 2005;43(6):1055-9.

Qian Y, Yin C, Chen Y, et al. Estrogen contributes to regulating iron metabolism through governing ferroportin signaling via an estrogen response element. Cell Signal. 2015;27(5):934-42.

Seo SK, Yun BH, Chon SJ, et al. Association of serum ferritin levels with metabolic syndrome and subclinical coronary atherosclerosis in postmenopausal Korean women. Clin Chim Acta. 2015;438:62-6.

Cho GJ, Shin JH, Yi KW, et al. Serum ferritin levels are associated with metabolic syndrome in postmenopausal women but not in premenopausal women. Menopause. 2011;18(10):1120-4.

Chon SJ, Choi YR, Roh YH, et al. Association between levels of serum ferritin and bone mineral density in Korean premenopausal and postmenopausal women: KNHANES 2008-2010. PLoS ONE. 2014;9(12):e114972.

The post Dear Mark: Iron Followup appeared first on Mark's Daily Apple.

[cynthiamwashington]

Dear Mark: Iron Followup

Last week’s post on iron levels got a big response and garnered a ton of questions from you guys. Today, I’m going to clarify a few things and answer as many questions as I can. First, do iron and ferritin levels mean different things for men and women? If so, how do those differences manifest? What about premenopausal women vs postmenopausal women? Second, what do we make of the fact that ferritin is also increased in times of inflammation? Is there a way to distinguish between elevated ferritin caused by inflammation and elevated ferritin caused by high iron? Third, is desiccated liver a good option for liver haters? And finally, I share some exciting plague news.

Let’s go:

Emma wrote:

I’d love to see more info on iron levels as they relate to men and women differently. I recently had an iron infusion for low ferretin, not thinking much would change I actually experienced so many positive effects I didn’t even know were coming my way. I’m less cold, no more afternoon fatigue, less hair falling out, no more random palpitations, improved restless leg syndrome and the number one big change is it improved anxiety levels – in fact my anxiety is now gone. The last two are due to a connection between iron and dopamine. I learnt that children with mental health issues are often treated for low ferretin where possible, elevating levels to around 100 showing positive results (would love to see literature on this), for me my ferretin went from 20 to 130 and its changed my life, at 31 I haven’t felt this good in years. Yay iron!

That’s awesome to hear. Yes, it’s important to stress the very basic essentiality of iron. Without it, we truly cannot produce energy. And since energy is the currency for everything that happens in the body, an iron deficiency makes everything start to fall apart.

As for gender and iron, there’s a lot to discuss.

A good portion of women with hemochromatosis never actually express it phenotypically, meaning their lab tests don’t show evidence of dysregulated iron metabolism or storage. According to one study of hemochromatosis homozygotes (people who inherited the mutation from both of their parents), being a woman makes it 16x more likely that your hereditary hemochromatosis won’t actually present as iron overload.

Another study found that among mostly-age-matched men (42 years) and women (39 years) with hemochromatosis, 78% of the men had iron overload while just 36% of the women had it. Iron overload was defined as transferrin saturation over 52% combined with ferritin levels of 300 ng/mL for men and 200 ng/mL for women.

High iron levels are more of an issue for postmenopausal women than premenopausal women. The latter group regularly sheds blood through menstruation, and if anything, they’re at a higher risk of low iron. Plus, estrogen is a key regulator of iron metabolism. As menopause sets in and estrogen diminishes, that regulation suffers.

For instance:

In postmenopausal Korean women, high ferritin levels predict metabolic syndrome and subclinical atherosclerosis.

High ferritin predicts metabolic syndrome in postmenopausal but not premenopausal women.

In premenopausal Korean women, higher ferritin levels predict better bone mineral density; menopause nullifies this relationship.

Remember that ferritin is actually a measurable protein bound to iron, so testing a ferritin level is technically an indirect way to measure iron. Why is this important? Another characteristic of ferritin (the protein) is that it is an ACUTE PHASE REACTANT. This means that ferritin levels can fluctuate with illnesses and other inflammatory states in the body that drive up a ferritin value that is not related to an actual iron level fluctuation. Don’t get ferritin checked when you are sick with a cold or other illness.

This is a great point.

Ferritin is marker of long term iron storage, but it’s also an acute phase reactant that up regulates in response to inflammation or oxidative stress.

If you want to be really careful, you should get a HS-CRP test—that measures your overall inflammatory status. If CRP is elevated, ferritin can be elevated without saying anything about your iron status.

Come to think of it, if elevated ferritin can be a marker of inflammation and oxidative stress, the inflammation could be responsible for some of the negative health effects linked to high ferritin. Or, if having too much iron in the body can increase oxidative damage, it may be that high iron levels are increasing inflammation which in turn increases ferritin even further. Biology gets messy. Lots of feedback loops. However, the fact that many studies cited in the previous iron post that use blood donation to treat high ferritin have positive results indicates that for most people, ferritin can be, in most situations, an accurate estimation of your iron status.

To make sure it’s an iron problem, get a transferrin saturation test as well. That indicates the amount of iron you’re absorbing, with below 20% being low and over 45% being high. People with high ferritin and high transferrin saturation do have high iron levels. People whose ferritin is artificially enhanced by inflammation will have normal transferrin saturation levels.

I have one last question on this. You say “Don’t stop eating liver every week.” If you can’t stand the taste of liver, what do you think about taking liver capsules made from grass-fed New Zealand beef every day instead?

That’s a great option. Go for it.

People should generally aim for 4-8 ounces of fresh liver a week. Note the amount of desiccated liver in your capsules and multiply by 3 to get the fresh liver equivalent, then take enough each day (or all at once) to hit 4-8 ounces over the week. I hear good things about this one.

Mark, Thank you for your article on HH. I carry the gene but have been managing my iron levels through phlebotomies. I am full Keto, meat and all and have found my iron levels have not been effected by going Keto. Early detection is the key and ongoing monitoring. Bring on the plague!!!

You joke about that now, but there’s a startup that’s breeding heritage rat fleas that produce a mild strain of the plague that evades the attention of the immune system and proliferates throughout the body to keep iron levels in check without killing you. I’m an early investor, have a couple swarms installed in my condo, and (knock on wood) so far have avoided anything worse than a sore throat and maybe a mild open sore or two. There’s actually a big rift forming between the techs who want to keep the fleas heritage and those who want to go ahead with CRISPR and engineer them. One variant has had a deer tick gene inserted that adds an anesthetic compound to the flea’s saliva. That way you can have a personal swarm on you and never feel any bites or itches.

I’m not sure about CRISPR just yet, but I gotta say it’s pretty nice to be covered in fleas and not feel the bites. Time will tell.

Ok, I’m joking.

That’s it for today, folks. I hope I’ve answered some of your concerns, and if not, let me know down below. Thanks for reading!

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Want to make fat loss easier? Try the Definitive Guide for Troubleshooting Weight Loss for free here.

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References:

Lainé F, Jouannolle AM, Morcet J, et al. Phenotypic expression in detected C282Y homozygous women depends on body mass index. J Hepatol. 2005;43(6):1055-9.

Qian Y, Yin C, Chen Y, et al. Estrogen contributes to regulating iron metabolism through governing ferroportin signaling via an estrogen response element. Cell Signal. 2015;27(5):934-42.

Seo SK, Yun BH, Chon SJ, et al. Association of serum ferritin levels with metabolic syndrome and subclinical coronary atherosclerosis in postmenopausal Korean women. Clin Chim Acta. 2015;438:62-6.

Cho GJ, Shin JH, Yi KW, et al. Serum ferritin levels are associated with metabolic syndrome in postmenopausal women but not in premenopausal women. Menopause. 2011;18(10):1120-4.

Chon SJ, Choi YR, Roh YH, et al. Association between levels of serum ferritin and bone mineral density in Korean premenopausal and postmenopausal women: KNHANES 2008-2010. PLoS ONE. 2014;9(12):e114972.

The post Dear Mark: Iron Followup appeared first on Mark's Daily Apple.

Article source here:Marks’s Daily Apple