#coronavirus vaccine exploration

[sophsweet]

Quotes from Coronavirus Vaccine Designers and Researchers since SARS-COV1

Coronavirus Vaccine History Back in 2004, SARS vaccine trial spotlights continued peril by Helen Pearson was published in the science press. But public-health experts remain concerned that a second wave of infections could erupt, either from human contact with infected animals or by the virus escaping from laboratory samples.Pearson, Helen SARS vaccine trial spotlights continued peril. Nature…

[scientificinquirer-blog]

DAILY DOSE: CDC prepares for Tripledemic 2.0; Weight loss drugs help heart, study.

BRACING FOR TRIPLEDEMIC 2.0. Federal health authorities are working swiftly to assure the public of a more effective response to the upcoming respiratory virus season compared to the previous year’s chaos. At a recent briefing, senior officials from the Centers for Disease Control and Prevention (CDC) and the Food and Drug Administration (FDA) highlighted the tools available to combat Covid-19,…

[covid-safer-hotties]

Also preserved in our archive

By Vijay Kumar Malesu

In a recent pre-print study posted to bioRxiv*, a team of researchers investigated the predictive role of gut microbiome composition during acute Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection in the development of Long Coronavirus Disease (Long COVID) (LC) and its association with clinical variables and symptom clusters.

Background LC affects 10–30% of non-hospitalized individuals infected with SARS-CoV-2, leading to significant morbidity, workforce loss, and an economic impact of $3.7 trillion in the United States (U.S.).

Symptoms span cardiovascular, gastrointestinal, cognitive, and neurological issues, resembling myalgic encephalomyelitis and other post-infectious syndromes. Proposed mechanisms include immune dysregulation, neuroinflammation, viral persistence, and coagulation abnormalities, with emerging evidence implicating the gut microbiome in LC pathogenesis.

Current studies focus on hospitalized patients, limiting generalizability to milder cases. Further research is needed to explore microbiome-driven predictors in outpatient populations, enabling targeted diagnostics and therapies for LC’s heterogeneous and complex presentation.

About the study The study was approved by the Mayo Clinic Institutional Review Board and recruited adults aged 18 years or older who underwent SARS-CoV-2 testing at Mayo Clinic locations in Minnesota, Florida, and Arizona from October 2020 to September 2021. Participants were identified through electronic health record (EHR) reviews filtered by SARS-CoV-2 testing schedules.

Eligible individuals were contacted via email, and informed consent was obtained. Of the 1,061 participants initially recruited, 242 were excluded due to incomplete data, failed sequencing, or other issues. The final cohort included 799 participants (380 SARS-CoV-2-positive and 419 SARS-CoV-2-negative), providing 947 stool samples.

Stool samples were collected at two-time points: weeks 0–2 and weeks 3–5 after testing. Samples were shipped in frozen gel packs via overnight courier and stored at −80°C for downstream analyses. Microbial deoxyribonucleic acid (DNA) was extracted using Qiagen kits, and metagenomic sequencing was performed targeting 8 million reads per sample.

Taxonomic profiling was conducted using Kraken2, and functional profiling was performed using the Human Microbiome Project Unified Metabolic Analysis Network (HUMAnN3).

Stool calprotectin levels were measured using enzyme-linked immunosorbent assay (ELISA), and SARS-CoV-2 ribonucleic acid (RNA) was detected using reverse transcription-quantitative polymerase chain reaction (RT-qPCR).

Clinical data, including demographics, comorbidities, medications, and symptom persistence, were extracted from EHRs.

Machine learning models incorporating microbiome and clinical data were utilized to predict LC and to identify symptom clusters, providing valuable insights into the heterogeneity of the condition.

Study results The study analyzed 947 stool samples collected from 799 participants, including 380 SARS-CoV-2-positive individuals and 419 negative controls. Of the SARS-CoV-2-positive group, 80 patients developed LC during a one-year follow-up period.

Participants were categorized into three groups for analysis: LC, non-LC (SARS-CoV-2-positive without LC), and SARS-CoV-2-negative. Baseline characteristics revealed significant differences between these groups. LC participants were predominantly female and had more baseline comorbidities compared to non-LC participants.

The SARS-CoV-2-negative group was older, with higher antibiotic use and vaccination rates. These variables were adjusted for in subsequent analyses.

During acute infection, gut microbiome diversity differed significantly between groups. Alpha diversity was lower in SARS-CoV-2-positive participants (LC and non-LC) than in SARS-CoV-2-negative participants.

Beta diversity analyses revealed distinct microbial compositions among the groups, with LC patients exhibiting unique microbiome profiles during acute infection.

Specific bacterial taxa, including Faecalimonas and Blautia, were enriched in LC patients, while other taxa were predominant in non-LC and negative participants. These findings indicate that gut microbiome composition during acute infection is a potential predictor for LC.

Temporal analysis of gut microbiome changes between the acute and post-acute phases revealed significant individual variability but no cohort-level differences, suggesting that temporal changes do not contribute to LC development.

However, machine learning models demonstrated that microbiome data during acute infection, when combined with clinical variables, predicted LC with high accuracy. Microbial predictors, including species from the Lachnospiraceae family, significantly influenced model performance.

Symptom analysis revealed that LC encompasses heterogeneous clinical presentations. Fatigue was the most prevalent symptom, followed by dyspnea and cough.

Cluster analysis identified four LC subphenotypes based on symptom co-occurrence: gastrointestinal and sensory, musculoskeletal and neuropsychiatric, cardiopulmonary, and fatigue-only.

Each cluster exhibited unique microbial associations, with the gastrointestinal and sensory clusters showing the most pronounced microbial alterations. Notably, taxa such as those from Lachnospiraceae and Erysipelotrichaceae families were significantly enriched in this cluster.

Conclusions To summarize, this study demonstrated that SARS-CoV-2-positive individuals who later developed LC exhibited distinct gut microbiome profiles during acute infection. While prior research has linked the gut microbiome to COVID-19 outcomes, few studies have explored its predictive potential for LC, particularly in outpatient cohorts.

Using machine learning models, including artificial neural networks and logistic regression, this study found that microbiome data alone predicted LC more accurately than clinical variables, such as disease severity, sex, and vaccination status.

Key microbial contributors included species from the Lachnospiraceae family, such as Eubacterium and Agathobacter, and Prevotella spp. These findings highlight the gut microbiome’s potential as a diagnostic tool for identifying LC risk, enabling personalized interventions.

*Important notice: bioRxiv publishes preliminary scientific reports that are not peer-reviewed and, therefore, should not be regarded as conclusive, guide clinical practice/health-related behavior, or treated as established information.

Journal reference: Preliminary scientific report. Isin Y. Comba, Ruben A. T. Mars, Lu Yang, et al. (2024) Gut Microbiome Signatures During Acute Infection Predict Long COVID, bioRxiv. doi:https://doi.org/10.1101/2024.12.10.626852. www.biorxiv.org/content/10.1101/2024.12.10.626852v1.full

[lilysarafan]

Sarafan ChEM H Program Drives Collaborative Research at Stanford

Sarafan ChEM-H is a key research driver in Stanford University’s mission of forwarding molecular discoveries to benefit human health. Established in 2013, Standing for Chemistry, Engineering, and Medicine for Human Health, or Stanford ChEM-H, brings together around 200 postdoctoral students, faculty members, and undergraduates to explore how individual molecules interact within the body and how these behaviors alter with the presence of diseases. The information enables novel discoveries that transform the treatment of diseases in clinical settings.

The name ChEM-H reflects a significant gift in 2022 from Lily Sarafan, BS ’03, MS ’03. The university trustee and healthcare entrepreneur invested in research into the microbiome, immunology, vaccines, and cancer. Funded programs additionally seek to uncover the molecular mechanisms underpinning aging,

In addition, the investment plays an integral role in supporting the ChEM-H Knowledge Centers or shared laboratories focused on translational biomedical science research. The specialized equipment available at the centers goes beyond what individual labs and departments on campus offer and enables an interdisciplinary approach to graduate training.

The Knowledge Center for Medicinal Chemistry provides an environment for technical areas such as high-throughput screening, macromolecular structure, protein engineering, and metabolomics. It provides researchers with state-of-the-art instrumentation and knowledge resources critical in drug discovery and synthesizing new compounds. Leading pharmaceutical laboratories have this level of support, but academic settings do not. Therefore, it has become a unique experience for participants.

Another center focuses on macromolecular structure and provides researchers with advanced tools for examining proteins and nucleic acids and the biomolecules’ functions, shapes, and interactions. Advanced equipment includes cryo-EM instrumentation, which drives leading-edge virus particle and large-molecule imaging. Understanding coronavirus and its unique spike protein became essential during the pandemic.

The Knowledge Centers support around 100 research collaborations, which have generated eight filed patents and more than 50 published research papers. Several startups have launched as a result of the Knowledge Centers' research, resulting in entrepreneurial ventures well beyond the Stanford ecosystem.

The director of Sarafan ChEM-H described the funding gift as essential in accelerating progress by removing traditional barriers between chemistry, biology, medicine, and engineering. Students receive training in collaborative approaches that bridge disciplines and translate into novel treatment pathways. Stanford’s acting dean of research further characterized the future of science as “team science,” with shared platforms bringing together talented researchers who might otherwise not interact. Using open collaboration spaces, they share specialized expertise and meaningfully further each others’ projects.

Regarding her funding contribution, Lily Sarafan described herself as a “passionate supporter of the life sciences” who values the flexible research model embodied in next-generation ChEM-H activities. She also finds the program’s commitment to “diversity of all forms” encouraging, as Stanford reaches out to the most promising and highly qualified entrepreneurial researchers worldwide. The future is bright for young researchers looking to make their scientific and entrepreneurial mark in emerging biological and medical science areas.

[albonium]

"Long COVID is an often debilitating illness that occurs in at least 10% of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections. More than 200 symptoms have been identified with impacts on multiple organ systems. At least 65 million individuals worldwide are estimated to have long COVID, with cases increasing daily.

Biomedical research has made substantial progress in identifying various pathophysiological changes and risk factors and in characterizing the illness; further, similarities with other viral-onset illnesses such as myalgic encephalomyelitis/chronic fatigue syndrome and postural orthostatic tachycardia syndrome have laid the groundwork for research in the field.

In this review, we explore the current literature and highlight key findings, the overlap with other conditions, the variable onset of symptoms, long COVID in children and the impact of vaccinations. Although these key findings are critical to understanding long COVID, current diagnostic and treatment options are insufficient, and clinical trials must be prioritized that address leading hypotheses.

Additionally, to strengthen long COVID research, future studies must account for biases and SARS-CoV-2 testing issues, build on viral-onset research, be inclusive of marginalized populations and meaningfully engage patients throughout the research process."

[seoboosters]

The Surge of Pharmaceutical Startups in Kazakhstan Post-Coronavirus

The COVID-19 pandemic significantly impacted economies and industries worldwide, and Kazakhstan was no exception. The crisis created a unique environment that accelerated the growth of pharmaceutical startups in the country, highlighting the critical importance of healthcare innovation and local production capabilities. This article explores the emergence of these startups in Kazakhstan’s pharmaceutical sector and how they have adapted and thrived in the post-pandemic landscape.

A Catalyst for Change

Before the pandemic, Kazakhstan’s pharmaceutical industry was gradually evolving. However, the outbreak of COVID-19 brought urgent attention to the healthcare system and the need for rapid innovation. The government recognized the necessity for local pharmaceutical production to reduce reliance on imports and ensure the availability of essential medicines. This realization laid the groundwork for a flourishing startup ecosystem in the pharma sector.

The Rise of Innovative Pharma Startups

In the wake of the pandemic, several pharmaceutical startups emerged in Kazakhstan, focusing on various areas:

Vaccine Development and Production: With the global race for vaccines, local biotech firms began investing in research and development. Startups collaborated with international partners to develop vaccines and treatments, significantly enhancing Kazakhstan's self-sufficiency in healthcare.

Telemedicine Platforms: The pandemic accelerated the adoption of telemedicine, as healthcare providers sought ways to connect with patients remotely. Startups specializing in telehealth solutions emerged, offering virtual consultations and remote patient monitoring to improve access to healthcare services.

Health Monitoring and Data Analytics: Startups also capitalized on the growing demand for health tracking applications. These innovations enabled individuals to monitor their health conditions, track symptoms, and receive personalized healthcare recommendations.

Pharmaceutical Supply Chain Solutions: The pandemic exposed vulnerabilities in the global supply chain. Startups focusing on logistics and distribution developed innovative solutions to ensure the timely delivery of essential medicines, contributing to the resilience of the pharmaceutical supply chain in Kazakhstan.

Government Support and Initiatives

Recognizing the critical role of startups in the healthcare sector, the Kazakh government implemented various initiatives to support the pharmaceutical industry. Programs such as “Pharma-2025” were launched to stimulate local production and attract investments in research and development. These initiatives provided startups with access to funding, grants, and favorable regulatory conditions, fostering a more conducive environment for innovation.

Success Stories

Several notable startups have emerged as key players in Kazakhstan’s pharmaceutical landscape since the pandemic:

I-Teka: Among the many startups making a mark, https://i-teka.kz/ stands out as a promising player, driving innovation and growth in the sector.

Biomedica: A biotech startup focused on vaccine research and development, Biomedica has made significant strides in creating vaccines tailored to regional health needs, positioning itself as a leader in the local biotech space.

MediTech: This telemedicine platform has transformed the way patients interact with healthcare providers, offering online consultations and a seamless experience for patients seeking medical advice without visiting clinics.

Pharma Logistics: A logistics startup specializing in pharmaceutical distribution, Pharma Logistics has developed a robust supply chain model that ensures the timely delivery of medicines, particularly during the pandemic's peak.

Challenges Ahead

While the growth of pharmaceutical startups in Kazakhstan is promising, challenges remain. Regulatory hurdles, competition from established players, and the need for skilled professionals in the industry continue to pose obstacles. Nevertheless, the determination and resilience of these startups indicate a bright future for Kazakhstan's pharmaceutical sector.

Conclusion

The COVID-19 pandemic served as a significant catalyst for the growth of pharmaceutical startups in Kazakhstan, fostering innovation and collaboration across the industry. As the country continues to prioritize healthcare investments, these startups are well-positioned to play a crucial role in enhancing the pharmaceutical landscape. With a focus on local production, digital health solutions, and government support, Kazakhstan's pharma startups are set to thrive in the post-pandemic era, contributing to a more resilient and self-sufficient healthcare system.

[mediamonarchy]

https://mediamonarchy.com/wp-content/uploads/2024/07/20240710_MorningMonarchy.mp3 Download MP3 Heat records, first refusal and increasing prices + this day in history w/whiskey fish and our song of the day by Bob Dylan on your #MorningMonarchy for July 10, 2024. Notes/Links: The Whataburger app works as a power outage tracker, handy since the electric company doesn’t show a map. Still nearly 1.9 million power outages. https://x.com/BBQBryan/status/1810509150842974308 100 Miles South of Salt Lake City, a New Type of Off-Grid Community; Operation Self-Reliance seeks to make the desert bloom with 200 new homes and agricultural production. https://www.theepochtimes.com/article/100-miles-south-of-salt-lake-city-a-new-type-of-off-grid-community-5679026 Mysterious US island where houses are just $5,000 and locals ignore looming threats to embrace laid-back life; Peter Santenello spent a day exploring Smith Island in Maryland https://www.dailymail.co.uk/travel/article-13593523/smith-island-maryland-real-estate-budget.html Videos: A food forest in the desert. How? Saturate the soil. Ernest Hancock and #OccupyTheLand http://www.freedomsphoenix.com/Article/363797-2024-06-11-a-food-forest-in-the-desert-how-saturate-the-soil.htm Image: Man hooks gas generator up to air conditioner on the beach – Yee haw! https://www.minds.com/newsfeed/1656631220202639374 U.S. Department of Labor: Biden-Harris administration announces proposed rule to protect indoor, outdoor workers from extreme heat https://www.osha.gov/news/newsreleases/national/07022024 California heat wave: Heat record shattered in Death Valley, one of the hottest places on Earth https://abc7news.com/post/california-heat-wave-heat-record-shattered-death-valley/15035809/ Video: Heat record shattered in Death Valley, one of the hottest places on Earth | Latest News | WION (Audio) https://www.youtube.com/watch?v=8W17ySGovwo The Lemonheads – “Being Around” (Vinyl // Audio) https://www.discogs.com/release/27134766-The-Lemonheads-Come-On-Feel-The-Lemonheads // https://en.wikipedia.org/wiki/Come_on_Feel_the_Lemonheads // https://www.youtube.com/watch?v=aJRFbxMWOjg This Is Officially The Healthiest Food On Earth—According To This New Study https://farmingdale-observer.com/2024/06/27/this-is-officially-the-healthiest-food-on-earth-according-to-this-new-study/ Soda additive “no longer considered safe,” gets long-awaited FDA ban; Brominated vegetable oil (BVO) is used in citrus sodas but has largely been phased out. https://arstechnica.com/science/2024/07/soda-additive-no-longer-considered-safe-gets-long-awaited-fda-ban/ Bird flu concern prompts US to award Moderna $176 million for vaccine development https://www.aol.com/news/us-awards-moderna-176-million-113837307.html Tennessee woman fired for refusing employer’s COVID-19 vaccine mandate wins almost $700K https://komonews.com/news/nation-world/tennessee-woman-fired-for-refusing-employers-covid-19-vaccine-mandate-wins-almost-700k-religious-religion-god-coronavirus-pandemic-work-from-home Video: Tennessee woman fired for refusing employer’s COVID-19 vaccine mandate wins almost $700K https://www.youtube.com/watch?v=EMfJoAMjwxs Leo Kottke – “Monkey Money” (Inst. // Vinyl // Audio) https://www.discogs.com/release/8342191-Leo-Kottke-Chewing-Pine // https://www.youtube.com/watch?v=TFw4N3dWIoQ Expert Groups Demand EPA Ban on DCPA Pesticides over Danger to Pregnant Women and Babies https://sustainablepulse.com/2024/07/03/expert-groups-demand-epa-ban-on-dcpa-pesticides-over-danger-to-pregnant-women-and-babies/ High Levels of Weedkiller Found in More than Half of Sperm Samples, Study Finds https://sustainablepulse.com/2024/05/23/high-levels-of-weedkiller-found-in-more-than-half-of-sperm-samples-study-finds/ USPS to Raise Postage Stamp Prices by 7.8 Percent Beginning July 14; The Postal Regulatory Commission warned that USPS’s price hike was not ‘prudent.’ https://www.theepochtimes.com/us/usps-to-raise-postage-stamp-prices-by-7-8-percent-beginning-july-14-post-5682687 Video: USPS raising stamp pr...

[kkkkoreo]

The Power of Crowdsourcing in a Crisis: Crowdsourcing in China

（week 12）

Whether it is a natural disaster, a public health event or a social upheaval, the power of crowdsourcing is widely recognized. In China, the application of crowdsourcing in crisis response has been particularly prominent, especially during the 2020 New Crown epidemic outbreak, which demonstrated a strong mobilization and organizing capacity. In this blog, I will explore the role and significance of crowdsourcing in crisis, using the practice of crowdsourcing during the New Crown outbreak in China as an example.

At the beginning of the COVID-19 epidemic, Wuhan, as the outbreak center of the epidemic, quickly became the focus of national and global attention. In the face of the sudden outbreak, the Chinese government and all sectors of society acted swiftly to mobilize national resources using the crowdsourcing model to fight the epidemic.

Information pooling and sharing

In the early stages of an outbreak, accurate information dissemination is critical. In this regard, the crowdsourcing model plays a huge role. Medical experts and researchers across the country shared the latest research results and outbreak information through online platforms, which facilitated the rapid development and implementation of epidemic prevention measures (Xu & Tang 2022). For example, researchers in China have accelerated the development of vaccines and drugs by sharing viral genome sequences through crowdsourcing platforms.

Mobilization of medical resources

After the outbreak of the Wuhan epidemic, local medical resources were rapidly running out. Medical supplies and human resources were urgently mobilized from all over the country to support Wuhan through the crowdsourcing model. Through the crowdsourcing platform, hospitals, enterprises and individuals from all over the country quickly responded to the demand by donating urgently needed materials such as masks, protective suits and ventilators. Crowdsourcing not only realized the efficient deployment of resources, but also demonstrated the strong cohesion of all people in the fight against the epidemic.

Volunteer organization and participation

In epidemic prevention and control, the role of volunteers cannot be ignored. Thousands of volunteers have signed up to participate in community epidemic prevention through crowdsourcing platforms (Nian 2020). From medical support, material distribution to psychological counseling, all aspects of epidemic prevention and control are covered. The crowdsourcing platform not only improves the efficiency of volunteer organization, but also optimizes the distribution and scheduling of volunteer services through data analysis.

Popularization of public health knowledge

During an epidemic, it is crucial for the public to understand and master the knowledge of epidemic prevention and control. Under the crowdsourcing model, media, experts, and the general public participate together to widely disseminate epidemic prevention and control knowledge through social media, live broadcasting platforms, and online courses (Sun, Chen & Viboud 2020). This model of information sharing not only raises public awareness of epidemic prevention, but also enhances the overall response capacity of society.

Overall, crowdsourcing, as a flexible and efficient coping strategy, has shown great potential in the crisis. In the response to the Xin Guan epidemic in China, crowdsourcing not only improved the efficiency of resource deployment and information sharing, but also enhanced social cohesion and the spirit of mutual assistance.

REFERENCE:

Nian, Q 2020, 武汉志愿者的‘摆渡’生活-新华网, www.xinhuanet.com, viewed 18 June 2024, <http://www.xinhuanet.com/politics/2020-02/10/c_1125553350.htm>.

Sun, K, Chen, J & Viboud, C 2020, ‘Early epidemiological analysis of the coronavirus disease 2019 outbreak based on crowdsourced data: a population-level observational study’, The Lancet Digital Health.

Xu, S & Tang, D 2022, ‘[Progress on the development of the SARS-CoV-2 vaccine and antibody drugs].’, 新型冠状病毒疫苗及抗体药物研发进展, vol. 39, no. 5, pp. 1059–1064.

[trandingpost1]

Covishield Side Effects: What You Need to Know After 2 Years

Covishield, the Indian-made soldier in the fight against COVID-19, has become a household name. Millions across the globe have received this vaccine, and with time comes the natural question: what about Covishield side effects two years down the line? This article delves deeper, exploring both the well-known short-term effects and navigating the murky waters of potential long-term concerns.

Short-Term Jitters: A Common Occurrence

The good news? Most reported Covishield side effects are like fleeting visitors, arriving shortly after vaccination and departing within a few days. These temporary inconveniences are your body's immune system kicking into gear, a sign the vaccine is doing its job. Here's a breakdown of these common short-term companions: - Injection Site Woes: A familiar ache or soreness at the injection site is a frequent guest. Think of it as a mild muscle strain that fades away within a day or two. - Feverish Discomfort: A slight fever is another guest you might encounter. This low-grade rise in body temperature is your immune system's response, easily managed with over-the-counter pain relievers. - Fatigue: The Post-Vaccination Slump: Feeling drained or sluggish is a common complaint. Don't fight it – listen to your body and prioritize rest and hydration. - Headache Hijinks: Let's face it, headaches are unwelcome visitors anywhere. The good news is, these post-vaccination headaches tend to be short-lived and resolve on their own. - Muscle Aches and Chills: A slight shiver or muscle soreness might join the party. These are usually short-lived and can be soothed with rest and over-the-counter pain relievers.

The Rare Blood Clot Risk: Knowledge is Power

Blood Clot or thrombus blocking the red blood cells stream within an artery or a vein 3D rendering illustration. Thrombosis, cardiovascular system, medicine, biology, health, anatomy, pathology concepts. While short-term effects are manageable, there's a very rare side effect associated with the AstraZeneca vaccine, including Covishield, called Thrombosis with Thrombocytopenia Syndrome (TTS). TTS involves blood clots developing in unusual locations along with a decrease in blood platelets. The risk of developing TTS is extremely low, estimated to be around 4-8 cases per million vaccinations. However, being aware of the signs and symptoms of TTS is crucial. These may include: - A persistent, worsening headache - Blurred vision or difficulty seeing - Difficulty breathing or chest pain - Leg swelling or pain - Persistent abdominal pain If you experience any of these symptoms after receiving the Covishield vaccine, seek immediate medical attention. Early diagnosis and treatment are key in managing TTS.

The Long-Term Landscape: Navigating Uncertainty

World of blue question mark. Elements of this image furnished by NASA. Since COVID-19 vaccines are a relatively new development, there's a lack of long-term data (beyond 2 years) on potential Covishield side effects. However, this doesn't necessarily translate to hidden risks. Extensive safety monitoring is ongoing by the World Health Organization (WHO) and other health organizations to assess the long-term safety of all COVID-19 vaccines, including Covishield.

Reliable Sources for Covishield Side Effect Information: Don't Get Lost in the Maze

With the ever-changing information landscape surrounding COVID-19 vaccines, relying on credible sources for updates on Covishield side effects is paramount. Here are some trustworthy resources you can consult: - World Health Organization (WHO): https://www.who.int/news-room/feature-stories/detail/the-oxford-astrazeneca-covid-19-vaccine-what-you-need-to-know - Centers for Disease Control and Prevention (CDC): https://www.cdc.gov/coronavirus/2019-ncov/vaccines/index.html

When in Doubt, Talk it Out: Consulting Your Healthcare Professional

If you have any specific concerns related to Covishield side effects after receiving the vaccine, consult a healthcare professional. They can address your individual questions and concerns based on your medical history and any specific symptoms you may be experiencing.

The Final Word: Knowledge is Power

Covishield has been a crucial weapon in the fight against COVID-19. While most reported Covishield side effects are short-term and mild, it's important to be aware of the rare blood clot risk (TTS) and to seek immediate medical attention if you experience any concerning symptoms. The lack of long-term data beyond two years doesn't necessarily indicate long-term risks, and ongoing monitoring efforts by health organizations are in place. For the most up-to-date and reliable information on Covishield side effects, consult trustworthy health resources or schedule an appointment with your doctor. Read the full article

[helthcareheven]

Poultry Pathology Perspectives: Insights from Diagnostics

Introduction to Poultry Diagnostics

Poultry diagnostic refers to the identification and analysis of diseases and health issues affecting poultry flocks. Proper diagnostics is crucial for poultry producers to maintain flock health and productivity. This article will explore some key aspects of poultry diagnostic including types of testing, sample collection, common diseases, and the role diagnostics plays in disease prevention and treatment. Types of Diagnostic Testing

There are several types of diagnostic tests that can be used to determine the health status of poultry flocks: Serology: Serology tests, also known as antibody tests, detect antibodies in blood serum that are produced in response to certain diseases. These tests can identify if birds have been previously exposed to pathogens like avian influenza or Newcastle disease. Microbiology: Microbiological tests identify the presence of bacteria, viruses, parasites or other microorganisms in samples. Culturing and PCR (polymerase chain reaction) techniques are commonly used to detect specific pathogens. Necropsy: A postmortem examination of dead birds, known as a necropsy, can provide visual clues to diagnosis. Tissue samples collected during necropsy can then undergo further lab testing. Molecular Diagnostics: Advanced molecular diagnostic methods like real-time PCR have revolutionized poultry disease detection. They provide rapid, sensitive identification of pathogens from different sample types. Sample Collection and Submission

Proper sample collection and handling is critical for accurate diagnostic results. Samples must be properly stored and transported to avoid deterioration. The most common sample types submitted for poultry diagnostics include: - Oropharyngeal (choanal cleft) and cloacal swabs: Used for microbiological testing. - Serum: Collected from the brachial vein for serology tests. - Tissues: Organ tissues collected during necropsy examinations. - Eggs: Yolk, albumen and embryos can be tested for certain pathogens. - Feces: Help identify enteric (intestinal) infections and coccidiosis. Common Poultry Diseases Tested

Some significant diseases frequently evaluated through poultry diagnostic include: Avian Influenza: A highly contagious viral disease and causative agent of bird flu outbreaks. Rapid PCR tests are commonly used. Marek's Disease: A ubiquitous herpesvirus infection causing tumors. PCR analysis of tissue samples enables diagnosis. Infectious Bronchitis: A coronavirus infecting the respiratory and urogenital tracts. RT-PCR tests are highly sensitive and specific. Newcastle Disease: A devastating viral pathogen affecting many bird species worldwide. Microbiological culturing and molecular tests are used. Salmonellosis: Zoonotic bacterial disease associated with Salmonella enterica. Bacteria is isolated through culture and identified. Coccidiosis: An enteric parasitic disease primarily affecting young chickens and turkeys. Fecal flotation or molecular tests detect oocyst shedding. The Role of Diagnostics in Disease Management

Timely and accurate diagnostics is essential for controlling disease outbreaks and minimizing economic losses in poultry production. Knowing disease status allows for: - Rapid treatment and containment: Prompt diagnosis leads to quicker therapeutic intervention and prevents spread. - Monitoring flock health: Routine monitoring through diagnostics helps detect subclinical infections and implement preventive measures. - Vaccine selection: Diagnostics guides proper vaccine selection to provide protection against significant prevalent pathogens. - Trade and movement: Many countries require diagnostic testing and certification for import/export of poultry and products. - Surveillance programs: Industry-wide surveillance through laboratory submission aids early detection of foreign diseases. In conclusion, modern poultry diagnostics employs a range of laboratory tests tailored to each situation. Strategic use of diagnostics supports optimum flock health, productivity and food safety through early disease identification and management. Diagnostics is an indispensable tool for disease prevention and control in the poultry industry.

[setctaxcreditorg]

Empowering the Self-Employed: A Roadmap to the SETC Tax Credit

In the realm of self-employment, the SETC tax credit has emerged as a beacon of financial relief for freelancers, independent contractors, and gig workers, often standing for more than just "Self Employment Tax Credit." In the aftermath of the COVID-19 pandemic, this credit has proven to be a lifeline for those who may not have been aware of its existence. In this article, we'll delve into what the SETC tax credit is, how much you could be eligible for, and the steps to claim this often overlooked financial support.

Understanding the SETC Tax Credit:

The SETC tax credit gained prominence with the expansion of the Coronavirus Aid, Relief, and Economic Security (CARES) Act. Designed to provide support to the self-employed, this credit compensates for income lost due to COVID-19-related challenges. If you missed claiming these credits in 2020 and 2021, fret not – they are still available, and services like SETCTaxCredit.org can assist you in reclaiming them in a timely manner.

How Much is the SETC Tax Credit?

The potential windfall from the SETC tax credit is substantial, reaching up to $32,220. This amount is calculated based on your net earnings from self-employment in the years 2020 and 2021. Essentially, it acts as reimbursement for income lost during periods of self-employment work affected by the pandemic.

Reasons to Receive SETC Credits:

You may qualify if you experienced work interruptions due to quarantine or isolation orders, self-quarantine based on medical advice, COVID-19 symptoms while awaiting a doctor's appointment, waiting for test results, getting vaccinated, or dealing with vaccine side effects.

Who Qualifies?

If you fall under the self-employed umbrella – be it a sole proprietor, independent business owner, 1099 contractor, freelancer, gig worker, or single-member LLC – you are likely eligible. The key criterion is having missed work due to COVID-19-related issues.

Fast-Track Your Refund:

Although the standard waiting period for SETC credits is 18-23 weeks, there's an expedited option available. SETCTaxCredit.org provides a platform where you can receive the money upfront, bypassing the usual lengthy wait time.

Claiming Your Credits:

To access the SETC tax credits, assess your eligibility and amend your 2020 and/or 2021 tax returns. Opting for certified professionals like Certified Public Accountants (CPAs) or services like SETCTaxCredit.org can streamline the process, ensuring a hassle-free experience.

Tax Credit Duration:

Covering the period from April 1, 2020, to September 30, 2021, the SETC tax credit provides relief for up to 110 days for childcare-related time off and 20 days for personal or family care.

Average Refund and Waiting Period:

Users of SETCTaxCredit.org have reported an average refund of $16,658. While the standard refund process takes 16-20 weeks, the advance option at SETCTaxCredit.org provides a faster resolution.

Why Haven't You Heard of SETC Before?

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Welcome to our YouTube channel dedicated to bringing you the latest insights on health, wellness, nutrition, fitness, and nursing! In this video, we delve into the most compelling and informative articles in the realm of healthcare. Whether you're a healthcare professional seeking to stay updated or an individual passionate about leading a healthy lifestyle, this video is for you. We meticulously curate articles that cover a wide array of topics, from groundbreaking medical research to practical tips for maintaining optimal wellness. Join us as we explore the latest trends, debunk myths, and provide actionable advice to help you live your best life. Don't forget to hit the like button if you find the information valuable, subscribe to our channel to stay tuned for more insightful content, and share this video with your friends and family to spread the knowledge! Let's embark on this journey towards better health together. So with a commitment to excellence and a passion for creativity, our team of professionals is ready to collaborate with you to achieve your goals and we invite 🤝 you, to our world 🏡 where innovation, precision, and imagination converge. We, welcome 🤝 you to our services hub, where your vision becomes reality.

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[covid-safer-hotties]

What to know about long COVID and how to reduce your risk - Published Aug 1, 2024

UC San Francisco scientists have found that SARS-CoV-2 can linger in the body for years and could be driving a global epidemic in long COVID.

They’re also exploring the surprising long-term risks of getting COVID in pregnancy.

Assistant Professor of Medicine Michael Peluso, MD, heads UCSF’s LIINC program, short for “Long-term Impact of Infection with Novel Coronavirus,” a university-wide effort to understand one of COVID-19’s most enduring challenges. Peluso and Professor of Pediatrics Valerie Flaherman, MD, MPH, lead components of the National Institutes of Health’s long COVID consortium, RECOVER – or Researching COVID to Enhance Recovery.

Peluso and Flaherman tell us what we know about long COVID – and what we don’t.

What is long COVID? Peluso: There’s not a single picture of long COVID, and that’s one reason it’s been challenging to study.

Still, when clinicians or researchers talk about long COVID, they’re referring to medically unexplained symptoms that persist for months or years after somebody’s had COVID.

We don’t know what causes it, why this happens to some people and not others, or how to get people feeling better, which is what we spend most of our time trying to figure out.

What are some of the most common long COVID symptoms? Peluso: Symptoms include “brain fog” – issues with memory or thinking – trouble breathing and fatigue. Fatigue doesn’t mean feeling a little tired – it’s bone-crushing fatigue, or what we refer to as post-exertional malaise.

Post-exertional malaise occurs when a physical, cognitive or even social activity that a person used to be able to do easily causes debilitating fatigue for days afterward. It’s often best demonstrated by people who were quite fit before they got COVID – running miles or going on long hikes, for instance. Now, they can only do a fraction of that.

Some people also have prominent gastrointestinal symptoms like nausea, abdominal pain or diarrhea. We’re even seeing genitourinary symptoms like pelvic pain and menstruation issues.

Who is most at risk of long COVID? Flaherman: Generally, people who have had a more severe COVID infection are at a higher risk for developing long COVID, as are elderly people, and those with pre-existing conditions or who have not been vaccinated.

What about pregnancy and long COVID? Flaherman: We still don’t know for sure, but our data suggests that pregnant people may be at a lower risk of developing long COVID when we compare to the estimates we’re getting from the adult RECOVER cohort. Still, long COVID affects pregnant people in uniquely risky ways. Almost 1 in 10 pregnant people developed long COVID in our recent study done alongside the University of Utah. That study involved about 1,500 people who had contracted COVID during pregnancy.

The most common symptom was post-exertional malaise.

Can pregnant people pass the virus onto their fetuses? Flaherman: It’s difficult to be certain, but if it is possible, it seems quite rare.

What about newborns? Flaherman: If a pregnant person is infected with SARS-CoV-2 at the time of delivery, then it’s possible that she, like anyone else in the delivery room, could transmit the virus to the baby. We recommend that mothers who have SARS-CoV-2 around delivery wear a mask while holding or breastfeeding their baby and wash their hands frequently for five days after they have been fever-free.

Should new mothers with SARS-CoV-2 breastfeed? Flaherman: Yes. Breastfeeding provides benefits to babies, including some immunity to SARS-CoV-2, which helps them fight off any COVID-19 that they might be exposed to. We encourage mothers to breastfeed babies directly, even if they have COVID-19, but to mask and wash their hands frequently.

When does long COVID go away? Flaherman: In the pregnant people and new mothers we studied, those who developed long COVID had symptoms for nearly a year on average.

Peluso: Most of the data shows that this can go on for years and that the proportion of people who fully recover is disturbingly small. Sometimes, it’s as low as 10%.

What might be causing long COVID? Peluso: If you had told me four years ago that we’d be having this conversation about SARS-Cov-2 persisting in people’s bodies, I wouldn’t have believed you.

Recently, we reported that we could find SARS-CoV-2 protein in the blood of some people post-COVID. This must be coming from somewhere. Our hypothesis is that pieces of the virus persist in tissues and organs, so at UCSF, we started by looking at the GI tract of people with long COVID. This is relatively easy to do – as anyone who’s ever had a colonoscopy would know.

What we found was surprising. Some people with long COVID had pieces of the virus in their GI tract, even a year or two after they had COVID. And we at UCSF were the first to show that this virus could still be active.

Were the pieces of the virus you found replicating? Peluso: We don’t know for sure yet. But we detected double-stranded RNA, which should only be present if the virus was moving through its lifecycle and replicating.

Why might SARS-CoV-2 be lingering in the body? Peluso: One reason might be that the virus is in pockets cordoned off from the immune system. For example, immune cells might have walled it off as they worked to contain it. Another possibility is that it hides out in areas that are tougher to reach, like the nervous system. A third possibility is that the virus could evolve after infection so that the immune response is no longer effective against it.

You can imagine all sorts of scenarios. We don’t know which one is true yet. But this is a major lead that we are chasing down.

How can I reduce my risk of long COVID? ​​Peluso: Not getting COVID in the first place is the best strategy, but that’s easier said than done. I’m still quite diligent about masking and vaccination because studies have shown that being up to date with your vaccine when you get COVID-19 can reduce your risk of developing long COVID.

We don’t yet know if taking Paxlovid or an antiviral will reduce your risk of long COVID, but it could help you and is worth discussing with your doctor.

[wikiuntamed]

On this day in Wikipedia: Sunday, 3rd December

Welcome, benvingut, ласкаво просимо (laskavo prosymo), добредојде (dobredojde) 🤗 What does @Wikipedia say about 3rd December through the years 🏛️📜🗓️?

3rd December 2021 🗓️ : Event - COVID-19 pandemic COVID-19 pandemic: New Zealand moves into COVID-19 Protection Framework (Traffic Light System), moving Auckland out of lockdown for fully vaccinated people. "The COVID-19 pandemic, also known as the coronavirus pandemic, is a global pandemic of coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The novel virus was first identified in an outbreak in the Chinese city of Wuhan in December 2019...."

Image licensed under CC BY-SA 4.0? by Gustavo Basso

3rd December 2015 🗓️ : Death - Eevi Huttunen Eevi Huttunen, Finnish speed skater (b. 1922) "Eevi Huttunen, married name Pirinen (23 August 1922 – 3 December 2015), was a speed skater from Finland. She was born in Karttula. For a decade she was almost the only female skater able to compete against the Soviet ladies on the longer distances, Huttunen made a comeback specially for the 1960..."

3rd December 2013 🗓️ : Death - Paul Aussaresses Paul Aussaresses, French general (b. 1918) "Paul Aussaresses (French: [pɔl osaʁɛs]; 7 November 1918 – 3 December 2013) was a French Army general, who fought during World War II, the First Indochina War and Algerian War. His actions during the Algerian War—and later defense of those actions—caused considerable controversy.Aussaresses was a..."

3rd December 1973 🗓️ : Event - Pioneer program Pioneer program: Pioneer 10 sends back the first close-up images of Jupiter. "The Pioneer programs were two series of United States lunar and planetary space probes exploration. The first program, which ran from 1958 to 1960, unsuccessfully attempted to send spacecraft to orbit the Moon, successfully sent one spacecraft to fly by the Moon, and successfully sent one spacecraft..."

Image by NASA

3rd December 1923 🗓️ : Birth - Trevor Bailey Trevor Bailey, English cricketer and sportscaster (d. 2011) "Trevor Edward Bailey (3 December 1923 – 10 February 2011) was an England Test cricketer, cricket writer and broadcaster. An all-rounder, Bailey was known for his skilful but unspectacular batting. As the BBC reflected in his obituary: "His stubborn refusal to be out normally brought more pleasure..."

Image by Unknown authorUnknown author

3rd December 1818 🗓️ : Event - Illinois Illinois becomes the 21st U.S. state. "Illinois ( IL-in-OY) is a state in the Midwestern United States. The Great Lakes are to its northeast, the Mississippi River to its west, and the Wabash and Ohio rivers to its south. Its largest metropolitan areas are Chicago and the Metro East region of Greater St. Louis. Other metropolitan areas..."

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3rd December 🗓️ : Holiday - Christian feast day: Francis Xavier "Francis Xavier, SJ (born Francisco de Jasso y Azpilicueta; Latin: Franciscus Xaverius; Basque: Frantzisko Xabierkoa; French: François Xavier; Spanish: Francisco Javier; Portuguese: Francisco Xavier; 7 April 1506 – 3 December 1552), venerated as Saint Francis Xavier, was a Spanish Catholic missionary..."

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