#cmdt

[malibuzz]

98e SESSION DU CONSEIL D'ADMINISTRATION DE LA CMDT : la Holding clôt avec un bénéfice net de 1,414 milliards

Les indicateurs de la CMDT affichent du vert en dépit d’une campagne précédente marquée par une baisse drastique de sa production, corollaire à la privation du Mali d’accès aux principaux ports d’approvisionnement par l’embargo sous-régional, aux inondations des cultures par les pluies diluviennes par endroit et surtout à l’invasion précoce des champs par de nouvelles espèces de Cicadelles…

[kwebtv]

Joseph Flaherty (June 21, 1941 – April 1, 2024) Actor, writer, and comedian. He is best known for his work on the Canadian sketch comedy SCTV from 1976 to 1984 (on which he also served as a writer), and as Harold Weir on Freaks and Geeks.

 He was one of the original writer/performers on SCTV, where he spent eight years on the show, playing such characters as Big Jim McBob (of Farm Film Report fame), Count Floyd/Floyd Robertson, and station owner/manager Guy Caballero, who goes around in a wheelchair only for respect and undeserved sympathy.

In 1989, Flaherty played a guest role in Married... with Children in the season-four episode "Tooth or Consequences", as a recently divorced dentist who must repair Al Bundy's teeth.

During 1997–1998, Flaherty starred in the television adaptation of Police Academy (Police Academy: The Series) as Cmdt. Stuart Hefilfinger. The series lasted for only one season.

In 1999, Flaherty joined the cast of Freaks and Geeks, an NBC hour-long dramedy set in the 1980–1981 academic year, in which he played Harold Weir, the irascible father of two teens. Despite a dedicated cult following, the show only lasted one season. In the third episode, "Tricks and Treats", he dons a cheap vampire costume reminiscent of his "Count Floyd" character of the depicted era.

Flaherty made appearances on the CBS sitcom The King of Queens as Father McAndrew, the priest at the Heffernans' church. He starred on the Bite TV original program, Uncle Joe's Cartoon Playhouse, and served as a judge on the CBC program The Second City's Next Comedy Legend. (Wikipedia)

IMDb Listing

[lessthanface]

寝坊するよ #キリトリセカイ #ファインダー越しの私の世界 #写真好きな人と繋がりたい #日々写真 #photography #photoshooting #photolife #photo #ig_photo #ig_japan #ig_daily #instalike #instagram #hueart_life #as_archive #photostagram #photogram_archive #HIBI_jp #RECO_IG #ishootphotos #neverstopexploring #snapshot #dailypic #foto https://www.instagram.com/p/CmdT-rGPBox/?igshid=NGJjMDIxMWI=

[sunaleisocial]

Killing the messenger

New Post has been published on https://sunalei.org/news/killing-the-messenger/

Killing the messenger

Like humans and other complex multicellular organisms, single-celled bacteria can fall ill and fight off viral infections. A bacterial virus is caused by a bacteriophage, or, more simply, phage, which is one of the most ubiquitous life forms on earth. Phages and bacteria are engaged in a constant battle, the virus attempting to circumvent the bacteria’s defenses, and the bacteria racing to find new ways to protect itself.

These anti-phage defense systems are carefully controlled, and prudently managed — dormant, but always poised to strike.

New open-access research recently published in Nature from the Laub Lab in the Department of Biology at MIT has characterized an anti-phage defense system in bacteria, CmdTAC. CmdTAC prevents viral infection by altering the single-stranded genetic code used to produce proteins, messenger RNA.

This defense system detects phage infection at a stage when the viral phage has already commandeered the host’s machinery for its own purposes. In the face of annihilation, the ill-fated bacterium activates a defense system that will halt translation, preventing the creation of new proteins and aborting the infection — but dooming itself in the process.

“When bacteria are in a group, they’re kind of like a multicellular organism that is not connected to one another. It’s an evolutionarily beneficial strategy for one cell to kill itself to save another identical cell,” says Christopher Vassallo, a postdoc and co-author of the study. “You could say it’s like self-sacrifice: One cell dies to protect the other cells.”

The enzyme responsible for altering the mRNA is called an ADP-ribosyltransferase. Researchers have characterized hundreds of these enzymes — although a few are known to target DNA or RNA, all but a handful target proteins. This is the first time these enzymes have been characterized targeting mRNA within cells.

Expanding understanding of anti-phage defense

Co-first author and graduate student Christopher Doering notes that it is only within the last decade or so that researchers have begun to appreciate the breadth of diversity and complexity of anti-phage defense systems. For example, CRISPR gene editing, a technique used in everything from medicine to agriculture, is rooted in research on the bacterial CRISPR-Cas9 anti-phage defense system.

CmdTAC is a subset of a widespread anti-phage defense mechanism called a toxin-antitoxin system. A TA system is just that: a toxin capable of killing or altering the cell’s processes rendered inert by an associated antitoxin.

Although these TA systems can be identified — if the toxin is expressed by itself, it kills or inhibits the growth of the cell; if the toxin and antitoxin are expressed together, the toxin is neutralized — characterizing the cascade of circumstances that activates these systems requires extensive effort. In recent years, however, many TA systems have been shown to serve as anti-phage defense.

Two general questions need to be answered to understand a viral defense system: How do bacteria detect an infection, and how do they respond?

Detecting infection

CmdTAC is a TA system with an additional element, and the three components generally exist in a stable complex: the toxic CmdT, the antitoxin CmdA, and an additional component called a chaperone, CmdC.

If the phage’s protective capsid protein is present, CmdC disassociates from CmdT and CmdA and interacts with the phage capsid protein instead. In the model outlined in the paper, the chaperone CmdC is, therefore, the sensor of the system, responsible for recognizing when an infection is occurring. Structural proteins, such as the capsid that protects the phage genome, are a common trigger because they’re abundant and essential to the phage.

The uncoupling of CmdC exposes the neutralizing antitoxin CmdA to be degraded, which releases the toxin CmdT to do its lethal work. 

Toxicity on the loose

The researchers were guided by computational tools, so they knew that CmdT was likely an ADP-ribosyltransferase due to its similarities to other such enzymes. As the name suggests, the enzyme transfers an ADP ribose onto its target.

To determine if CmdT interacted with any sequences or positions in particular, they tested a mix of short sequences of single-stranded RNA. RNA has four bases: A, U, G, and C, and the evidence points to the enzyme recognizing GA sequences.

The CmdT modification of GA sequences in mRNA blocks their translation. The cessation of creating new proteins aborts the infection, preventing the phage from spreading beyond the host to infect other bacteria.

“Not only is it a new type of bacterial immune system, but the enzyme involved does something that’s never been seen before: the ADP-ribsolyation of mRNA,” Vassallo says.

Although the paper outlines the broad strokes of the anti-phage defense system, it’s unclear how CmdC interacts with the capsid protein, and how the chemical modification of GA sequences prevents translation.

Beyond bacteria

More broadly, exploring anti-phage defense aligns with the Laub Lab’s overall goal of understanding how bacteria function and evolve, but these results may have broader implications beyond bacteria.

Senior author Michael Laub, Salvador E. Luria Professor and Howard Hughes Medical Institute Investigator, says the ADP-ribosyltransferase has homologs in eukaryotes, including human cells. They are not well studied, and not among the Laub Lab’s research topics, but they are known to be up-regulated in response to viral infection.

“There are so many different — and cool — mechanisms by which organisms defend themselves against viral infection,” Laub says. “The notion that there may be some commonality between how bacteria defend themselves and how humans defend themselves is a tantalizing possibility.” 

[jcmarchi]

Killing the messenger

New Post has been published on https://thedigitalinsider.com/killing-the-messenger/

Killing the messenger

Like humans and other complex multicellular organisms, single-celled bacteria can fall ill and fight off viral infections. A bacterial virus is caused by a bacteriophage, or, more simply, phage, which is one of the most ubiquitous life forms on earth. Phages and bacteria are engaged in a constant battle, the virus attempting to circumvent the bacteria’s defenses, and the bacteria racing to find new ways to protect itself.

These anti-phage defense systems are carefully controlled, and prudently managed — dormant, but always poised to strike.

New open-access research recently published in Nature from the Laub Lab in the Department of Biology at MIT has characterized an anti-phage defense system in bacteria, CmdTAC. CmdTAC prevents viral infection by altering the single-stranded genetic code used to produce proteins, messenger RNA.

This defense system detects phage infection at a stage when the viral phage has already commandeered the host’s machinery for its own purposes. In the face of annihilation, the ill-fated bacterium activates a defense system that will halt translation, preventing the creation of new proteins and aborting the infection — but dooming itself in the process.

“When bacteria are in a group, they’re kind of like a multicellular organism that is not connected to one another. It’s an evolutionarily beneficial strategy for one cell to kill itself to save another identical cell,” says Christopher Vassallo, a postdoc and co-author of the study. “You could say it’s like self-sacrifice: One cell dies to protect the other cells.”

The enzyme responsible for altering the mRNA is called an ADP-ribosyltransferase. Researchers have characterized hundreds of these enzymes — although a few are known to target DNA or RNA, all but a handful target proteins. This is the first time these enzymes have been characterized targeting mRNA within cells.

Expanding understanding of anti-phage defense

Co-first author and graduate student Christopher Doering notes that it is only within the last decade or so that researchers have begun to appreciate the breadth of diversity and complexity of anti-phage defense systems. For example, CRISPR gene editing, a technique used in everything from medicine to agriculture, is rooted in research on the bacterial CRISPR-Cas9 anti-phage defense system.

CmdTAC is a subset of a widespread anti-phage defense mechanism called a toxin-antitoxin system. A TA system is just that: a toxin capable of killing or altering the cell’s processes rendered inert by an associated antitoxin.

Although these TA systems can be identified — if the toxin is expressed by itself, it kills or inhibits the growth of the cell; if the toxin and antitoxin are expressed together, the toxin is neutralized — characterizing the cascade of circumstances that activates these systems requires extensive effort. In recent years, however, many TA systems have been shown to serve as anti-phage defense.

Two general questions need to be answered to understand a viral defense system: How do bacteria detect an infection, and how do they respond?

Detecting infection

CmdTAC is a TA system with an additional element, and the three components generally exist in a stable complex: the toxic CmdT, the antitoxin CmdA, and an additional component called a chaperone, CmdC.

If the phage’s protective capsid protein is present, CmdC disassociates from CmdT and CmdA and interacts with the phage capsid protein instead. In the model outlined in the paper, the chaperone CmdC is, therefore, the sensor of the system, responsible for recognizing when an infection is occurring. Structural proteins, such as the capsid that protects the phage genome, are a common trigger because they’re abundant and essential to the phage.

The uncoupling of CmdC exposes the neutralizing antitoxin CmdA to be degraded, which releases the toxin CmdT to do its lethal work. 

Toxicity on the loose

The researchers were guided by computational tools, so they knew that CmdT was likely an ADP-ribosyltransferase due to its similarities to other such enzymes. As the name suggests, the enzyme transfers an ADP ribose onto its target.

To determine if CmdT interacted with any sequences or positions in particular, they tested a mix of short sequences of single-stranded RNA. RNA has four bases: A, U, G, and C, and the evidence points to the enzyme recognizing GA sequences.

The CmdT modification of GA sequences in mRNA blocks their translation. The cessation of creating new proteins aborts the infection, preventing the phage from spreading beyond the host to infect other bacteria.

“Not only is it a new type of bacterial immune system, but the enzyme involved does something that’s never been seen before: the ADP-ribsolyation of mRNA,” Vassallo says.

Although the paper outlines the broad strokes of the anti-phage defense system, it’s unclear how CmdC interacts with the capsid protein, and how the chemical modification of GA sequences prevents translation.

Beyond bacteria

More broadly, exploring anti-phage defense aligns with the Laub Lab’s overall goal of understanding how bacteria function and evolve, but these results may have broader implications beyond bacteria.

Senior author Michael Laub, Salvador E. Luria Professor and Howard Hughes Medical Institute Investigator, says the ADP-ribosyltransferase has homologs in eukaryotes, including human cells. They are not well studied, and not among the Laub Lab’s research topics, but they are known to be up-regulated in response to viral infection.

“There are so many different — and cool — mechanisms by which organisms defend themselves against viral infection,” Laub says. “The notion that there may be some commonality between how bacteria defend themselves and how humans defend themselves is a tantalizing possibility.” 

[christophe76460]

Je préfère que ma langue loue et prie mon Dieu. Je préfère que mon esprit adore le Seigneur. Je préfère que mon coeur chérisse mon Sauveur. Que dès ici-bas mon âme le bénisse.

Nous vivons environ 70 à 80 ans et quelquefois plus. Alors j'aimerai que la majorité de ce temps de conscience soit consacré à ses deux "demandes" et "cmdts" : "Tu aimeras le Seigneur ton Dieu de tout ton coeur, et de toute ton âme, et de toute ta pensée. Et tu aimeras ton prochain comme toi-même".

Que celui qui ne connait pas Jésus-Christ soit ma préoccupation. Et que celui qui le connaît déjà soit un sujet de mes prières.

M'asseoir dans le coeur du Seigneur c'est une grâce, me tenir à ses pieds c'est un honneur.

C'est de l'obéissance et de l'amour que j'aurais eu pour mon Seigneur que ma vie sera réussie.

Soyons d'abord avec le Seigneur avant de faire pour Lui.

I prefer my tongue to praise and pray to my God. I prefer my spirit to worship the Lord. I prefer my heart to cherish my Savior. May my soul bless him from here on earth.

We live about 70 to 80 years and sometimes more. So I would like the majority of this conscious time to be devoted to his two “requests” and “comdts”: “You shall love the Lord your God with all your heart, and with all your soul, and with all your mind. And you shall love your neighbor as yourself.”

Let him who does not know Jesus Christ be my concern. And let him who already knows him be a subject of my prayers.

To sit in the heart of the Lord is a grace, to stand at his feet is an honor.

It is from the obedience and love I had for my Lord that my life will be successful.

Let us be with the Lord first before doing for Him.

[textileebook]

Current Medical Diagnosis and Treatment 2024, 63rd Edition PDF by Maxine A Papadakis, Stephen J McPhee, Michael W Rabow and Kenneth R McQuaid

Current Medical Diagnosis and Treatment 2024, 63rd Edition By Maxine A. Papadakis, Stephen J. McPhee, Michael W. Rabow and Kenneth R. McQuaid Contents: Authors vii Preface xv In Memoriam xvii YEAR IN REVIEW: KEY CLINICAL UPDATES IN CMDT 2024 Disease Prevention & Health Promotion 1 Michael Pignone, MD, MPH Common Symptoms 15 Paul L. Nadler, MD, & Ralph Gonzales, MD, MSPH Preoperative…

[drsibia]

With mention of E.C.P. in CMDT 2024, patients will have treatment with increased confidence to recover from angina chest pain

[victor-tello-world]

🌏#TeVeO_PERU | Fenómeno del Niño COER recomienda tomar medidas de precaución ante tormentas eléctricas _Rayos impactan en viviendas de Sullana y deja una persona herida_ De acuerdo al reporte de precipitaciones pluviales del Servicio Nacional de Meteorología e Hidrología del Perú (Senamhi), la estación que registra el mayor acumulado (durante la tarde noche del 27 a la madrugada del 28 de marzo) es Lancones con 73.8 milímetros, categorizado como extremadamente lluvioso, seguido de la estación Mallares (Sullana), que registra un acumulado de 49.3 milímetros. Al respecto, el coordinador del Centro de Operaciones de Emergencia Regional (COER), Cmdt. PNP (R) Gonzalo Flores Lozano, informó que debido a las fuertes precipitaciones del día de ayer, una persona del sexo masculino (33), del centro poblado Mallares (Marcavelica), resultó herida tras la caída de un rayo en su vivienda, siendo atendido en el Hospital de Apoyo Sullana. Asimismo, la Sub Gerencia de Gestión del Riesgo de Desastres de la Municipalidad Distrital de Lancones ha comunicado que en el caserío Duran, una vivienda resultó afectada por la caída de un rayo, el cual ocasionó la destrucción total del medidor de luz, antena de televisión y la muerte de cinco animales. Por su parte, el jefe de la Oficina de Gestión del Riesgo de Desastres de la Municipalidad Distrital de Querecotillo, reportó que debido a las intensas lluvias de ayer, 04 familias han resultado damnificadas, 02 de ellas corresponden al C.P. Puente de los Serranos y 02 al C.P. Santa Cruz. El funcionario manifiesta que aún continúan evaluando daños en la zona. _Se pronostican lluvias con descargas eléctricas_ Ante los avisos meteorológicos N° 59 y N° 61 del Senamhi, que pronostican lluvias de moderada a extrema intensidad en costa norte y sierra, las cuales estarían acompañadas de descargas eléctricas y ráfagas de viento. Ante ello, el coordinador del COER recomendó a la población que de registrarse una tormenta eléctrica tenga en cuenta las siguientes medidas de precaución: No tener contacto con agua ni usar objetos metálicos; no usar el teléfono ni equipos electrónicos y vehículos, ya que estos pueden atraer las tormentas eléctr (en Agencia MTV) https://www.instagram.com/p/CqWjjTjscKb/?igshid=NGJjMDIxMWI=

[gbwhtspro]

Vasan Bala on Cinema Marte Dum Tak, His Favourite Pulpy Films and the Documentation of Art Forms

Yes, they’re beautiful pictures. We as a country aren’t really into documentation. So many silent-era films, so many films from the Seventies and Eighties might have been lost. We don’t take much care in preserving for future generations to have a reference point or a library to access. It’s a sad reality. But, yes, through this [CMDT], there is at least second-hand information on them. All these…

[tavischefbiggers]

GOOD MORNING 🌍 https://www.instagram.com/p/Cmdt-zfO6u-/?igshid=NGJjMDIxMWI=

[malibuzz]

99ÈME SESSION DU CONSEIL D'ADMINISTRATION DE LA CMDT: Le PDG Nango Dembélé salue l'appui gouvernemental

Les  travaux  de  cette  99ième  session annuelle  de la  CMDT,  tenue  le mercredi�� 20 décembre  2023��  à  l’hôtel de l’amitié  qui, de  par  ses   réalisations soumises   à l’approbation,   se révèlent  satisfaisants.  En effet le  budget 2024  de la CMDT  a   été arrêté  en produits  pour  un montant  de   515, 454 milliards  FCFA,  en  charges à  514, 310 de F et en investissements pour  12,…

[sczerbetto]

#bibliobibuli #leitura #livros #leitores #frases #citações #pensamentos #books #reading #readers #libri #lettura #lettori #livres #lecteurs #lecture https://www.instagram.com/p/Cmdt-LFu0Vb/?igshid=NGJjMDIxMWI=

[bethatsitsi]

😎😎🤗🤗🤗 https://www.instagram.com/p/CmdT-KcjZp0/?igshid=NGJjMDIxMWI=

[cmndrt]

#TroyBoi - #Do you? (#dance / #electronicdancemusic. A Jewel: hefty basses and catchy melody. Tipp: Watch that Original Video.) #Music #song #songoftheday #cmdt #neks #picsart #pics #photo #foto #like #shit #wtf #niceone #damn #chill #fun #parrisgoebel #taktixfilms https://www.instagram.com/p/B_NgzSVoKPn/?igshid=1xvlen3h7u1

[smledd]

Usmle First Aid 2021 India Edition

Usmle First Aid 2021 India Edition is Written by Tao Le Vikas Bhushan. This book is must for every medical student who wants to appear on the Usmle First Step 1 Examination. https://www.aibh.in/product/5083/current-medical-diagnosis-treatment-60-th-edition-2021-by-maxine-a-papada